DT-Web

DB01174 - Phenobarbital


Identification
Name Phenobarbital
Accession Number DB01174 (APRD00184)
Type small molecule
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 232.2353
Groups approved
Monoisotopic Weight 232.08479226
Pharmacology
Indication For the treatment of all types of seizures except absence seizures.
Mechanism of action Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Absorption Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach.
Protein binding 20 to 45%
Biotransformation Hepatic (mostly via CYP2C19).
Route of elimination Not Available
Toxicity CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol The barbiturate, phenobarbital, decreases the anticoagulant effect of acenocoumarol.
Aminophylline The barbiturate, phenobarbital, decreases the effect of aminophylline.
Anisindione The barbiturate, phenobarbital, decreases the anticoagulant effect of anisindione.
Asenapine Phenobarbital is a CYP1A2 inducer and may increase metabolism of asenapine.
Bendamustine Increases levels of bendamustine by decreasing metabolism. Ethinyl Estradiol is a CYP1A2 inhibitor and concurrent administration may result in elevated plasma concentrations of bendamustine.
Betamethasone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, betamethasone.
Boceprevir Strong CYP3A4 inducers will decrease levels of boceprevir. Concomitant therapy is contraindicated.
Cabazitaxel Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Canagliflozin Nonselective inducers of UGT enzymes may decrease levels of canagliflozin, thus decreasing efficacy. Consider increase the dose to 300 mg once daily.
Chlorotrianisene The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, chlorotrianisene.
Clomifene The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, clomifene.
Conjugated Estrogens The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Cortisone acetate The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, cortisone acetate.
Cyclosporine The barbiturate, phenobarbital, may decrease the therapeutic effect of cyclosporine by increasing its metabolism.
Dabrafenib Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Dasatinib Phenobarbital may decrease the serum level and efficacy of dasatinib.
Delavirdine The anticonvulsant, phenobarbital, decreases the effect of delavirdine.
Dexamethasone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Dicumarol The barbiturate, phenobarbital, decreases the anticoagulant effect, dicumarol.
Diethylstilbestrol The enzyme inducer, phenobarbital, may decrease the therapeutic effect of diethylstilbestrol.
Disopyramide Phenobarbital decreases levels of disopyramide
Doxycycline The anticonvulsant, phenobarbital, may decrease the therapeutic effect of doxycycline.
Dyphylline The barbiturate, phenobarbital, decreases the effect of dyphylline.
Estradiol The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estradiol.
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Estriol The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estriol.
Estrone The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estrone.
Estropipate The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estropipate.
Ethinyl Estradiol This product may cause a slight decrease of contraceptive effect
Etravirine Etravirine, when used concomitantly with phenobarbital, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Felbamate Felbamate increases the effect and toxicity of phenobarbital/primidone
Felodipine The barbiturate, phenobarbital, decreases the effect of felodipine.
Fludrocortisone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Folic Acid Folic acid decreases the effect of anticonvulsant, phenobarbital.
Gefitinib The CYP3A4 inducer, phenobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Griseofulvin The barbiturate, phenobarbital, decreases the effect of griseofulvin.
Hydrocortisone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Imatinib Phenobarbital decreases levels of imatinib
Itraconazole The barbiturate, phenobarbital, decreases the effect of itraconazole.
Ivacaftor Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Levonorgestrel Phenobarbital decreases the effect of levonorgestrel
Medroxyprogesterone The enzyme inducer, phenobarbital, may decrease the effect of the hormone, medroxyprogesterone.
Megestrol The enzyme inducer, phenobarbital, may decrease the effect of the hormone, megestrol.
Mestranol This product may cause a slight decrease of contraceptive effect
Methadone The barbiturate, phenobarbital, decreases the effect of methadone.
Methoxyflurane The barbiturate, phenobarbital, increases the renal toxicity of methoxyflurane.
Methylprednisolone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, methylprednisolone.
Metoprolol The barbiturate decreases the effect of the metabolized beta-blocker
Metronidazole The barbiturate, phenobarbital, decreases the effect of metronidazole.
Nifedipine The barbiturate, phenobarbital, may decrease the effect of the calcium channel blocker, nifedipine.
Norethindrone This product may cause a slight decrease of contraceptive effect
Oxtriphylline The barbiturate, phenobarbital, decreases the effect of oxtriphylline.
Paramethasone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, paramethasone.
Prednisolone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, prednisolone.
Prednisone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, prednisone.
Propranolol The barbiturate decreases the effect of the metabolized beta-blocker
Quinestrol The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, quinestrol.
Quinidine The anticonvulsant, phenobarbital, decreases the effect of quinidine.
Regorafenib Strong CYP3A4 inducers may decrease levels of regorafenib.
Rilpivirine Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast. Also decreases the level or effect of roflumilast by affecting CYP1A2 metabolism.
Rufinamide Increases clearance of rufinamide thus decreasing plasma concentration of rufinamide.
Sunitinib Possible decrease in sunitinib levels
Tacrolimus Phenobarbital may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Phenobarbital therapy is initiated, discontinued or altered.
Telithromycin Phenobarbital may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus Phenobarbital may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Theophylline The barbiturate, phenobarbital, decreases the effect of theophylline.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Phenobarbital. Consider alternate therapy or monitor for adverse/toxic effects of Phenobarbital if Ticlopidine is initiated, discontinued or dose changed.
Tipranavir Phenobarbial decreases the concentration of Tipranavir. Monitor for decreased Tipranavir efficacy.
Tramadol Phenobarbital may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inducer, Phenobarbital, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Phenobarbital is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inducer, Phenobarbital, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Phenobarbital is initiated, discontinued or dose changed.
Triamcinolone The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, triamcinolone.
Trimipramine The barbiturate, Phenobarbital, may increase the metabolism and clearance of Trimipramine. Monitor for changes in the therapeutics and adverse effects of Trimipramine if Phenobarbital is initiated, discontinued or dose changed. Dose adjustments of Trimipramine may be required.
Triprolidine The CNS depressants, Triprolidine and Phenobarbital, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Ulipristal Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vemurafenib Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Verapamil Phenobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Phenobarbital is initiated, discontinued or dose changed.
Vigabatrin Vigabatrin reduces serum concentrations of phenobarbital by 8-16%.
Voriconazole Phenobarbital may reduce serum concentrations and efficacy of voriconazole. Concomitant voriconazole and long-acting barbiturates therapy is contraindicated.
Warfarin Phenobarbital may decrease the serum concentration of warfarin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of warfarin if phenobarbital is initiated, discontinued or dose changed.
Food Interactions
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take on an empty stomach for quicker absorption
  • Avoid alcohol.
  • Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
  • Macdonald RL, McLean MJ: Anticonvulsant drugs: mechanisms of action. Adv Neurol. 1986;44:713-36. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9218
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.8457
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions Not Available
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.834
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7821
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.8403
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
DTHybrid score 0.782
Neuronal acetylcholine receptor subunit alpha-4
Name Neuronal acetylcholine receptor subunit alpha-4
Gene Name CHRNA4
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.7228
Neuronal acetylcholine receptor subunit alpha-7
Name Neuronal acetylcholine receptor subunit alpha-7
Gene Name CHRNA7
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.7229
Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
  • Jin LJ, Schlesinger F, Song YP, Dengler R, Krampfl K: The interaction of the neuroprotective compounds riluzole and phenobarbital with AMPA-type glutamate receptors: a patch-clamp study. Pharmacology. 2010;85(1):54-62. doi: 10.1159/000268641. Epub 2009 Dec 23. - Pubmed
DTHybrid score 1.3322
Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.8642

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan LS, LeCluyse EL, Zech K, Robertson P Jr, Koch P, Antonian L, Wagner G, Yu L, Parkinson A: Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31. - Pubmed
DTHybrid score 0.8841
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kawalek JC, Howard KD, Farrell DE, Derr J, Cope CV, Jackson JD, Myers MJ: Effect of oral administration of low doses of pentobarbital on the induction of cytochrome P450 isoforms and cytochrome P450-mediated reactions in immature Beagles. Am J Vet Res. 2003 Sep;64(9):1167-75. - Pubmed
DTHybrid score 0.9694
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6459
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kawalek JC, Howard KD, Farrell DE, Derr J, Cope CV, Jackson JD, Myers MJ: Effect of oral administration of low doses of pentobarbital on the induction of cytochrome P450 isoforms and cytochrome P450-mediated reactions in immature Beagles. Am J Vet Res. 2003 Sep;64(9):1167-75. - Pubmed
DTHybrid score 0.7348
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • von Bahr C, Steiner E, Koike Y, Gabrielsson J: Time course of enzyme induction in humans: effect of pentobarbital on nortriptyline metabolism. Clin Pharmacol Ther. 1998 Jul;64(1):18-26. - Pubmed
  • Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999 Jun;39(6):567-77. - Pubmed
DTHybrid score 1.3575
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K, Nemoto N: Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Drug Metab Dispos. 1999 Mar;27(3):379-84. - Pubmed
DTHybrid score 0.8502
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kawalek JC, Howard KD, Farrell DE, Derr J, Cope CV, Jackson JD, Myers MJ: Effect of oral administration of low doses of pentobarbital on the induction of cytochrome P450 isoforms and cytochrome P450-mediated reactions in immature Beagles. Am J Vet Res. 2003 Sep;64(9):1167-75. - Pubmed
DTHybrid score 0.5371
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6255
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7015
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2076
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5075
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2827
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3354
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5455
Cytochrome P450 4B1
Name Cytochrome P450 4B1
Gene Name CYP4B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. - Pubmed
DTHybrid score Not Available

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inducer
References
  • Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed
  • Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. Epub 2008 Sep 11. - Pubmed
DTHybrid score 0.819
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inducer
References
  • Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y: cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett. 1998 Aug 14;433(1-2):149-52. - Pubmed
  • Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD: Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos. 2003 Nov;31(11):1315-9. - Pubmed
  • Slitt AL, Cherrington NJ, Maher JM, Klaassen CD: Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metab Dispos. 2003 Sep;31(9):1176-86. - Pubmed
  • Ogawa K, Suzuki H, Hirohashi T, Ishikawa T, Meier PJ, Hirose K, Akizawa T, Yoshioka M, Sugiyama Y: Characterization of inducible nature of MRP3 in rat liver. Am J Physiol Gastrointest Liver Physiol. 2000 Mar;278(3):G438-46. - Pubmed
DTHybrid score 0.2272
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inducer
References
  • Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12. - Pubmed
DTHybrid score 0.2799
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inducer
References
  • Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y: cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett. 1998 Aug 14;433(1-2):149-52. - Pubmed
DTHybrid score 0.3436
Solute carrier organic anion transporter family member 2A1
Name Solute carrier organic anion transporter family member 2A1
Gene Name SLCO2A1
Actions inducer
References
  • Hagenbuch N, Reichel C, Stieger B, Cattori V, Fattinger KE, Landmann L, Meier PJ, Kullak-Ublick GA: Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J Hepatol. 2001 Jun;34(6):881-7. - Pubmed
DTHybrid score 0.2572
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Courtois A, Payen L, Le Ferrec E, Scheffer GL, Trinquart Y, Guillouzo A, Fardel O: Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes. Biochem Pharmacol. 2002 Jan 15;63(2):333-41. - Pubmed
  • Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
  • Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12. - Pubmed
  • Kauffmann HM, Schrenk D: Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun. 1998 Apr 17;245(2):325-31. - Pubmed
  • Johnson DR, Habeebu SS, Klaassen CD: Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. Toxicol Sci. 2002 Mar;66(1):16-26. - Pubmed
DTHybrid score 0.4163

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.6652
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.3172
587 Serum albumin ALB 0.2278
20 Prostaglandin G/H synthase 1 PTGS1 0.2235
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.2166
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.2158
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.2155
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.2071
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1972
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1962
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1958
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1945
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1943
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.194
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1934
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1931
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1929
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.189
1729 Solute carrier family 22 member 6 SLC22A6 0.1563
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.1451
2164 Multidrug resistance-associated protein 4 ABCC4 0.138
6144 Solute carrier family 22 member 2 SLC22A2 0.1336
811 Translocator protein TSPO 0.1315
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1258
6145 Solute carrier family 22 member 1 SLC22A1 0.1256
3811 Cytochrome P450 19A1 CYP19A1 0.1208
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1179
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1105
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1065
6142 Solute carrier family 22 member 8 SLC22A8 0.1033
492 Histamine H1 receptor HRH1 0.1011
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1
6143 Solute carrier family 22 member 7 SLC22A7 0.0975
290 Prostaglandin G/H synthase 2 PTGS2 0.097
824 Sodium-dependent serotonin transporter SLC6A4 0.0949
118 Organic cation/carnitine transporter 2 SLC22A5 0.094
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0925
136 Estrogen receptor ESR1 0.0917
6148 Multidrug resistance-associated protein 7 ABCC10 0.091
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0907
817 DNA topoisomerase 2-alpha TOP2A 0.0902
6141 Sodium/bile acid cotransporter SLC10A1 0.0857
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0849
6031 Cytochrome P450 3A43 CYP3A43 0.0834
502 5-hydroxytryptamine 2A receptor HTR2A 0.078
6147 Solute carrier family 22 member 3 SLC22A3 0.0765
831 D(2) dopamine receptor DRD2 0.0758
6137 Multidrug resistance-associated protein 6 ABCC6 0.0753
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.073
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0725
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0717
6136 Multidrug resistance-associated protein 5 ABCC5 0.0716
1024 Solute carrier family 22 member 11 SLC22A11 0.0695
556 Alpha-1A adrenergic receptor ADRA1A 0.0693
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0644
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0634
871 Glucocorticoid receptor NR3C1 0.0629
731 HIV-1 protease HIV-1 protease 0.0622
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0619
260 Cytochrome P450 51 ERG11 0.0618
761 Cytochrome P450 51 ERG11 0.0618
3163 Cytochrome P450 51 cyp51 0.0618
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0591
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0581
3947 Xanthine dehydrogenase/oxidase XDH 0.0563
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0562
847 Mu-type opioid receptor OPRM1 0.0562
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0556
320 5-hydroxytryptamine 1A receptor HTR1A 0.0551
318 Alpha-2A adrenergic receptor ADRA2A 0.0549
3923 Cholinesterase BCHE 0.0543
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0541
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0529
833 Organic cation/carnitine transporter 1 SLC22A4 0.0528
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0522
465 Calmodulin CALM1 0.0519
52 Pyruvate kinase isozymes R/L PKLR 0.0518
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0514
23 D(1A) dopamine receptor DRD1 0.0512
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0507
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0505
2922 Glycerol kinase glpK 0.0504
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0501
3937 Fatty-acid amide hydrolase FAAH 0.0499
3941 Amine oxidase [flavin-containing] A MAOA 0.0485
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0482
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.048
766 Beta-2 adrenergic receptor ADRB2 0.048
738 Monocarboxylate transporter 1 SLC16A1 0.0473
590 5-hydroxytryptamine 2C receptor HTR2C 0.0468
482 Glycine receptor subunit alpha-1 GLRA1 0.0462
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.046
341 5-hydroxytryptamine 3 receptor HTR3A 0.0459
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0445
467 Delta-type opioid receptor OPRD1 0.0444
477 DNA topoisomerase 4 subunit A parC 0.0443
886 DNA topoisomerase 4 subunit A parC 0.0443
6226 DNA topoisomerase 4 subunit A parC 0.0443
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0442
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0442
380 Cytochrome P450 17A1 CYP17A1 0.0442
404 DNA gyrase subunit A gyrA 0.0436
6224 DNA gyrase subunit A gyrA 0.0436
713 Sodium-dependent dopamine transporter SLC6A3 0.0431
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0423
632 Alpha-1B adrenergic receptor ADRA1B 0.042
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0418
6014 Cytochrome P450 2A13 CYP2A13 0.0416
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0411
614 Progesterone receptor PGR 0.041
85 Growth hormone receptor GHR 0.041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0405
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0403
450 Muscarinic acetylcholine receptor M4 CHRM4 0.04
6085 Fatty acid-binding protein, intestinal FABP2 0.0399
696 Kappa-type opioid receptor OPRK1 0.0398
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0395
4604 Liver carboxylesterase 1 CES1 0.0388
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0387
2206 Glucose-6-phosphate isomerase GPI 0.0381
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0376
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0375
161 Tubulin beta chain TUBB 0.0374
312 Tubulin beta chain TUB2 0.0374
193 Beta-1 adrenergic receptor ADRB1 0.0372
3939 Amine oxidase [flavin-containing] B MAOB 0.0372
6102 Arylamine N-acetyltransferase 2 NAT2 0.0369
844 Epidermal growth factor receptor EGFR 0.0369
1757 Myeloperoxidase MPO 0.0361
4120 NADPH--cytochrome P450 reductase POR 0.0359
70 Type-1 angiotensin II receptor AGTR1 0.0356
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0356
705 Glutamate receptor 1 GRIA1 0.0356
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.035
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0348
29 Tubulin beta-1 chain TUBB1 0.0347
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0347
84 Nuclear receptor 0B1 NR0B1 0.0346
146 Androgen receptor AR 0.0346
885 5-hydroxytryptamine 1B receptor HTR1B 0.0342
6220 Aryl hydrocarbon receptor AHR 0.0341
638 D(3) dopamine receptor DRD3 0.0339
3426 Glutamine synthetase glnA 0.0339
3987 Glutamine synthetase GLUL 0.0339
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0339
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0333
122 P2Y purinoceptor 12 P2RY12 0.0333
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0329
6182 Cytochrome P450 2J2 CYP2J2 0.0328
777 Tumor necrosis factor TNF 0.0327
172 Potassium channel subfamily K member 1 KCNK1 0.0326
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0322
3932 Glutathione S-transferase A2 GSTA2 0.0321
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0318
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0314
504 Mast/stem cell growth factor receptor KIT 0.0308
737 Mineralocorticoid receptor NR3C2 0.0307
537 ATP synthase delta chain, mitochondrial ATP5D 0.0305
24 Thymidylate synthase TMP1 0.0303
359 Thymidylate synthase TYMS 0.0303
2626 Thymidylate synthase thyA 0.0303
2729 Thymidylate synthase thyA 0.0303
5352 Thymidylate synthase THYA 0.0303
1010 Cytochrome P450 51A1 CYP51A1 0.0298
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0297
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0296
908 Glutathione S-transferase theta-1 GSTT1 0.0294
869 Estrogen receptor beta ESR2 0.0294
789 Alpha-1D adrenergic receptor ADRA1D 0.0289
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0288
489 Monocarboxylate transporter 2 SLC16A7 0.0283
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0283
725 5-hydroxytryptamine 1D receptor HTR1D 0.0282
273 Apoptosis regulator Bcl-2 BCL2 0.0281
629 Alpha-2B adrenergic receptor ADRA2B 0.0281
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0278
527 Prostacyclin receptor PTGIR 0.0278
16 Adenosine A1 receptor ADORA1 0.0276
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0269
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0268
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0267
904 Glutathione S-transferase P GSTP1 0.0267
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0265
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0262
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0261
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0259
756 Sex hormone-binding globulin SHBG 0.0259
36 Insulin receptor INSR 0.0258
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0257
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0255
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0254
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0254
1852 Microtubule-associated protein 2 MAP2 0.0252
891 Dihydropteroate synthase folP 0.0252
5359 Dihydropteroate synthase folP 0.0252
7175 Dihydropteroate synthase sulI 0.0252
1178 Adenosine A2a receptor ADORA2A 0.0248
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0248
5923 Microtubule-associated protein tau MAPT 0.0245
5924 Microtubule-associated protein 4 MAP4 0.0245
2808 Chloramphenicol acetyltransferase 3 cat3 0.0243
251 Alcohol dehydrogenase 1A ADH1A 0.024
4311 tRNA TRDMT1 0.024
4325 tRNA trmD 0.024
4328 tRNA trmD 0.024
228 Beta platelet-derived growth factor receptor PDGFRB 0.0239
2539 Tubulin alpha-1 chain TUBA4A 0.0238
33 Cystine/glutamate transporter SLC7A11 0.0237
6146 High affinity copper uptake protein 1 SLC31A1 0.0237
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0237
373 Transthyretin TTR 0.0237
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0236
2853 14 kDa fatty acid-binding protein Not Available 0.0235
1192 Sulfotransferase 1A1 SULT1A1 0.0234
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0234
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0234
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0234
378 Alpha-2C adrenergic receptor ADRA2C 0.0233
6020 Aldehyde oxidase AOX1 0.0233
820 Glycine receptor subunit alpha-2 GLRA2 0.0233
1629 Transcription factor AP-1 JUN 0.0232
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0232
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0231
2183 Fatty acid-binding protein, adipocyte FABP4 0.0227
275 Arachidonate 5-lipoxygenase ALOX5 0.0226
407 Vascular endothelial growth factor receptor 2 KDR 0.0224
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0224
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0222
444 Alcohol dehydrogenase 1B ADH1B 0.0222
517 Alcohol dehydrogenase 1C ADH1C 0.0222
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0221
4192 DNA topoisomerase 2-beta TOP2B 0.0221
5650 NimA-related protein DR_0842 0.0218
6167 Organic solute transporter subunit beta OSTB 0.0217
6166 Organic solute transporter subunit alpha OSTA 0.0217
469 Annexin A1 ANXA1 0.0217
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0216
2449 Tubulin alpha-3 chain TUBA1A 0.0216
26 Vascular endothelial growth factor receptor 3 FLT4 0.0216
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0215
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.0215
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0212
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0211
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0209
49 Endothelin B receptor EDNRB 0.0209
284 DNA-directed RNA polymerase beta chain rpoB 0.0209
5773 DNA-directed RNA polymerase beta chain rpoB 0.0209
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0207
32 Vascular endothelial growth factor receptor 1 FLT1 0.0206
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0206
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
683 Potassium transporter GK0582 0.0203
7 Nitric oxide synthase, inducible NOS2 0.02
432 D(4) dopamine receptor DRD4 0.02
4384 Capsule biosynthesis protein synC 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
716 5-hydroxytryptamine 7 receptor HTR7 0.0198
818 50S ribosomal protein L10 rplJ 0.0198
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0198
6163 Copper-transporting ATPase 2 ATP7B 0.0197
6165 Copper-transporting ATPase 1 ATP7A 0.0197
578 Endothelin-1 receptor EDNRA 0.0197
94 5-hydroxytryptamine 4 receptor HTR4 0.0197
124 Histamine H2 receptor HRH2 0.0195
4237 50S ribosomal protein L22 rplV 0.0195
500 Monocarboxylate transporter 4 SLC16A3 0.0193
719 Retinoic acid receptor responder protein 1 RARRES1 0.0193
770 Retinoic acid-induced protein 3 GPRC5A 0.0193
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0192
4238 50S ribosomal protein L4 rplD 0.0191
5578 50S ribosomal protein L4 rplD 0.0191
6173 50S ribosomal protein L4 rplD 0.0191
6219 50S ribosomal protein L4 rplD 0.0191
4203 Histamine N-methyltransferase HNMT 0.019
357 Carbonic anhydrase 2 CA2 0.019
952 Dipeptidyl peptidase 4 DPP4 0.019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0189
1116 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 0.0188
569 Retinal dehydrogenase 2 ALDH1A2 0.0187
896 Glutathione S-transferase Mu 1 GSTM1 0.0186
232 Corticosteroid-binding globulin SERPINA6 0.0186
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0186
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0185
88 Retinoic acid receptor RXR-beta RXRB 0.0184
4122 Histone deacetylase 2 HDAC2 0.0183
780 Retinoic acid receptor RXR-gamma RXRG 0.0181
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0181
3270 Elongation factor G fusA 0.0181
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0181
461 Glycine receptor subunit alpha-3 GLRA3 0.0181
613 Atrial natriuretic peptide receptor A NPR1 0.0179
4228 Keratin, type II cytoskeletal 7 KRT7 0.0177
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0176
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0175
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0175
611 Retinal dehydrogenase 1 ALDH1A1 0.0174
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0173
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0172
131 Synaptic vesicular amine transporter SLC18A2 0.0172
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0171
3809 Estrogen-related receptor gamma ESRRG 0.017
427 Substance-P receptor TACR1 0.017
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
571 Melatonin receptor type 1A MTNR1A 0.0169
362 Melatonin receptor type 1B MTNR1B 0.0169
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0168
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0167
723 Cytosolic phospholipase A2 PLA2G4A 0.0166
6174 50S ribosomal protein L32 rpmF 0.0165
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0163
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
436 5-hydroxytryptamine 2B receptor HTR2B 0.0162
13 Aminomethyltransferase, mitochondrial AMT 0.0162
6151 Monocarboxylate transporter 10 SLC16A10 0.0161
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0161
923 Glutamate receptor 3 GRIA3 0.0159
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0159
3810 Catechol O-methyltransferase COMT 0.0159
558 Solute carrier family 12 member 1 SLC12A1 0.0159
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0159
474 Acetylcholinesterase ACHE 0.0158
1656 CYP2B protein CYP2B 0.0157
365 Dihydrofolate reductase DHFR 0.0157
2381 Dihydrofolate reductase DFR1 0.0157
2833 Dihydrofolate reductase Not Available 0.0157
2931 Dihydrofolate reductase folA 0.0157
3544 Dihydrofolate reductase folA 0.0157
3682 Dihydrofolate reductase folA 0.0157
6642 Dihydrofolate reductase folA 0.0157
6756 Dihydrofolate reductase dfrA 0.0157
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0156
162 Retinoic acid receptor gamma-1 RARG 0.0156
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0154
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0154
165 FL cytokine receptor FLT3 0.0154
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0154
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0153
823 Fibroblast growth factor receptor 2 FGFR2 0.0152
1050 Bile salt sulfotransferase SULT2A1 0.0152
2981 Phospholipase A2, membrane associated PLA2G2A 0.0151
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
814 Ryanodine receptor 1 RYR1 0.015
6599 HTH-type transcriptional regulator ttgR ttgR 0.015
592 Carbonic anhydrase 4 CA4 0.0148
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0148
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0148
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0148
1792 Tissue-type plasminogen activator PLAT 0.0147
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
295 Carbonic anhydrase 1 CA1 0.0146
1650 Heme carrier protein 1 SLC46A1 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
6149 Solute carrier family 22 member 10 SLC22A10 0.0143
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0142
6138 Multidrug resistance protein 3 ABCB4 0.0142
1517 Beta-3 adrenergic receptor ADRB3 0.0141
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0141
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0141
528 5-hydroxytryptamine 1E receptor HTR1E 0.0139
5934 Cytochrome P450 26A1 CYP26A1 0.0138
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0138
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0138
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0137
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0136
1256 5-hydroxytryptamine 6 receptor HTR6 0.0136
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0136
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0135
174 Sigma 1-type opioid receptor SIGMAR1 0.0134
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0134
3587 Gastrotropin FABP6 0.0134
2298 Cytochrome P450-cam camC 0.0133
771 Pyruvate carboxylase, mitochondrial PC 0.0132
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
1714 Mitogen-activated protein kinase 3 MAPK3 0.013
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.013
3307 Acriflavine resistance protein B acrB 0.013
3808 Dihydropteroate synthase 2 folP2 0.0129
3601 Dihydropteroate synthase 1 folP1 0.0129
3807 Dihydropteroate synthase 1 folP1 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
6432 Transporter snf 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0125
183 Vascular endothelial growth factor A VEGFA 0.0125
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0125
117 Sterol O-acyltransferase 1 SOAT1 0.0125
6043 Putative G-protein coupled receptor 44 GPR44 0.0125
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
293 Gamma-glutamyl hydrolase GGH 0.0124
5626 Nucleoside diphosphate kinase B NME2 0.0123
1353 DNA topoisomerase 1 TOP1 0.0123
3552 DNA topoisomerase 1 topA 0.0123
672 Prostaglandin F2-alpha receptor PTGFR 0.0123
68 Cannabinoid receptor 1 CNR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
1569 G1/S-specific cyclin-D1 CCND1 0.0121
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.012
2230 Catalase CAT 0.012
3249 Catalase katA 0.012
3625 Catalase katA 0.012
4539 Catalase katA 0.012
4941 Catalase katB 0.012
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0119
518 Peroxidase/catalase T katG 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0118
5787 Angiopoietin-1 receptor TEK 0.0116
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0116
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0116
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0116
48 Pyridoxal kinase PDXK 0.0116
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0116
4773 Deoxycytidine kinase DCK 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0115
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0115
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0115
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0115
6210 Tubulin delta chain TUBD1 0.0114
6212 Tubulin gamma-1 chain TUBG1 0.0114
6211 Tubulin epsilon chain TUBE1 0.0114
239 Coagulation factor X F10 0.0114
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.011
890 Niemann-Pick C1-like protein 1 NPC1L1 0.011
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0109
2443 Azurin azu 0.0108
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0108
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0108
319 Opioid receptor, sigma 1 OPRS1 0.0107
563 Thyroid peroxidase TPO 0.0106
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0106
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
6168 Solute carrier family 22 member 16 SLC22A16 0.0105
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0104
163 D(1B) dopamine receptor DRD5 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
5294 Nucleoside diphosphate kinase A NME1 0.01
1176 Mitogen-activated protein kinase 1 MAPK1 0.01
768 FK506-binding protein 1A FKBP1A 0.01
1618 High affinity nerve growth factor receptor NTRK1 0.0098
106 Cannabinoid receptor 2 CNR2 0.0098
976 Platelet glycoprotein IX GP9 0.0098
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0097
936 Ephrin type-A receptor 2 EPHA2 0.0097
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0097
1760 Aminopeptidase N ANPEP 0.0097
6843 Aminopeptidase N pepN 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
208 DNA-directed RNA polymerase beta' chain rpoC 0.0096
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0096
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
751 Potassium channel subfamily K member 6 KCNK6 0.0095
291 Nitric-oxide synthase, endothelial NOS3 0.0094
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0094
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0094
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0093
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0093
484 Tyrosine-protein kinase ABL2 ABL2 0.0093
54 Prothrombin F2 0.0093
1630 Integrin beta-2 ITGB2 0.0093
6044 Serum paraoxonase/lactonase 3 PON3 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0092
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0091
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
153 Dopamine beta-hydroxylase DBH 0.0091
1275 Estrogen sulfotransferase SULT1E1 0.009
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.009
342 P protein [Includes: DNA-directed DNA polymerase P 0.009
612 P protein [Includes: DNA-directed DNA polymerase P 0.009
2236 Casein kinase II subunit alpha CSNK2A1 0.0089
511 5-hydroxytryptamine 1F receptor HTR1F 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
218 Monocarboxylate transporter 5 SLC16A4 0.0088
195 Monocarboxylate transporter 7 SLC16A6 0.0088
397 Monocarboxylate transporter 3 SLC16A8 0.0088
429 Monocarboxylate transporter 6 SLC16A5 0.0088
702 UMP-CMP kinase CMPK1 0.0088
267 Plasminogen activator inhibitor 1 SERPINE1 0.0088
3830 Calreticulin CALR 0.0088
199 Monocarboxylate transporter 8 SLC16A2 0.0088
992 Protein tyrosine kinase 2 beta PTK2B 0.0088
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0088
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0088
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
6126 Carbonic anhydrase 7 CA7 0.0086
299 Folate receptor beta FOLR2 0.0086
718 Folate receptor gamma FOLR3 0.0086
804 Mitochondrial folate transporter/carrier SLC25A32 0.0086
4226 Uridine phosphorylase 2 UPP2 0.0085
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0085
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0084
3856 Fibroblast growth factor receptor 3 FGFR3 0.0084
1063 Signal transducer and activator of transcription 5B STAT5B 0.0084
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0084
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0083
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0083
268 Adenosine A2b receptor ADORA2B 0.0083
2112 Toll-like receptor 9 TLR9 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
6218 Pannexin-1 PANX1 0.0082
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0082
3957 Adenosine deaminase ADA 0.0082
6034 Hydroxyindole O-methyltransferase ASMT 0.0081
6035 Nuclear receptor ROR-beta RORB 0.0081
6036 Eosinophil peroxidase EPX 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
1483 Membrane copper amine oxidase AOC3 0.0081
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.008
1196 Complement decay-accelerating factor CD55 0.008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.008
856 Vitamin D3 receptor VDR 0.0079
6221 Steroid hormone receptor ERR1 ESRRA 0.0079
1039 Histone deacetylase 9 HDAC9 0.0079
4225 Uridine phosphorylase 1 UPP1 0.0078
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0078
581 Cytochrome P450 2R1 CYP2R1 0.0077
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0077
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0076
4103 Proteasome subunit beta type 2 PSMB2 0.0076
4102 Proteasome subunit beta type 5 PSMB5 0.0076
4101 Proteasome subunit beta type 1 PSMB1 0.0076
76 Nitric-oxide synthase, brain NOS1 0.0076
1541 Metalloproteinase mmp20 0.0074
3639 Thymidine phosphorylase deoA 0.0074
3936 Thymidine phosphorylase TYMP 0.0074
1313 Lactoylglutathione lyase GLO1 0.0074
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0074
413 Amidophosphoribosyltransferase PPAT 0.0073
2515 Amidophosphoribosyltransferase purF 0.0073
3714 Amidophosphoribosyltransferase purF 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0073
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0073
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0073
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0073
2391 Ferrochelatase hemH 0.0072
6502 Ferrochelatase DKFZp686P18130 0.0072
1591 Ferrochelatase, mitochondrial FECH 0.0072
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0072
3904 Alanine aminotransferase 2 GPT2 0.0072
735 Alanine aminotransferase 1 GPT 0.0072
1360 Sphingomyelin phosphodiesterase SMPD1 0.0072
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0071
765 Indoleamine 2,3-dioxygenase IDO1 0.0071
634 Squalene monooxygenase SQLE 0.0071
7196 Squalene monooxygenase ERG1 0.0071
714 Glutathione reductase, mitochondrial GSR 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
734 D1 dopamine receptor-interacting protein calcyon CALY 0.007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0068
244 Angiotensin-converting enzyme ACE 0.0068
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0068
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0068
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0067
3913 Glutamic acid decarboxylase GAD65 0.0066
6824 Tyrosine-protein kinase Lyn LYN 0.0066
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0066
164 Histamine H4 receptor HRH4 0.0066
6042 Prostaglandin reductase 2 PTGR2 0.0064
2599 Tyrosine-protein kinase HCK HCK 0.0064
2216 Fibroblast growth factor receptor 4 FGFR4 0.0064
1820 Beta-nerve growth factor NGF 0.0064
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
1992 Vitamin D-binding protein GC 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0063
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0063
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0063
6493 Cytochrome c oxidase subunit 6C COX6C 0.0063
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0063
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0063
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0062
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0062
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0062
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0062
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0062
6559 Cytochrome c oxidase subunit 2 ctaC 0.0062
6669 Cytochrome c oxidase subunit 2 ctaC 0.0062
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0062
6558 Cytochrome c oxidase subunit 1 ctaD 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0062
6837 Serine/threonine-protein kinase 17B STK17B 0.0062
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0061
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
572 Integrin alpha-L ITGAL 0.006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.006
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.006
2232 Interleukin-5 IL5 0.0059
1593 Mucin-2 MUC2 0.0059
5880 Thrombopoietin receptor MPL 0.0058
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0058
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0058
2540 Choloylglycine hydrolase cbh 0.0057
400 Coagulation factor IX F9 0.0057
5461 Coagulation factor IX F9 0.0057
5818 Folate receptor alpha FOLR1 0.0057
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0055
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0055
1268 Neuropeptide S receptor NPSR1 0.0055
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0055
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0055
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0055
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0055
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0055
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0055
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0055
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0055
1374 Natriuretic peptides B NPPB 0.0054
1827 Gap junction alpha-1 protein GJA1 0.0054
1908 Vascular cell adhesion protein 1 VCAM1 0.0054
6501 Fatty acid-binding protein, liver FABP1 0.0054
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
3086 Plasmepsin-2 Not Available 0.0053
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0052
604 Vitamin K-dependent protein Z PROZ 0.0052
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
6073 Potassium channel subfamily K member 9 KCNK9 0.0049
6072 Potassium channel subfamily K member 3 KCNK3 0.0049
2207 Rhodopsin RHO 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
422 Vitamin K-dependent protein C PROC 0.0048
1245 Vitamin K-dependent protein S PROS1 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
1253 Interferon gamma IFNG 0.0046
173 Toll-like receptor 7 TLR7 0.0046
2021 Thrombomodulin THBD 0.0045
6500 Phospholipase A2 PLA2G1B 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0045
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0044
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0044
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0044
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0044
1864 RET proto-oncogene RET 0.0042
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0042
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0042
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
473 L-lactate dehydrogenase A chain LDHA 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0039
4041 Microsomal glutathione S-transferase 2 MGST2 0.0039
798 Osteocalcin BGLAP 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6228 Nuclear receptor coactivator 1 NCOA1 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6241 Nuclear receptor coactivator 2 NCOA2 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6131 Carbonic anhydrase 14 CA14 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0036
3404 Exotoxin A eta 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
369 Coagulation factor VII F7 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
1928 Leukotriene C4 synthase LTC4S 0.0034
4034 Glutaredoxin-1 GLRX 0.0034
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0034
4037 Hypothetical protein GPX1 0.0034
4297 Hypothetical protein SP_1951 0.0034
4521 Hypothetical protein BC_2969 0.0034
4540 Hypothetical protein TM_1070 0.0034
4555 Hypothetical protein MT1739 0.0034
4569 Hypothetical protein mshD 0.0034
4578 Hypothetical protein PA3270 0.0034
4747 Hypothetical protein PA3967 0.0034
5177 Hypothetical protein TM_0096 0.0034
5194 Hypothetical protein PA1204 0.0034
5240 Hypothetical protein Rv2991 0.0034
5370 Hypothetical protein TM_1158 0.0034
5710 Hypothetical protein Tb927.5.1360 0.0034
907 Glutathione peroxidase 2 GPX2 0.0034
4029 Microsomal glutathione S-transferase 3 MGST3 0.0034
4032 Microsomal glutathione S-transferase 1 MGST1 0.0034
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0034
910 Epididymal secretory glutathione peroxidase GPX5 0.0034
4040 Glutathione peroxidase 7 GPX7 0.0034
4036 Glutathione peroxidase 6 GPX6 0.0034
903 Glutathione S-transferase A5 GSTA5 0.0034
906 Glutathione peroxidase 1 GPX1 0.0034
900 Glutathione S-transferase A4 GSTA4 0.0034
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0034
911 Glutathione peroxidase 3 GPX3 0.0034
4035 Glutathione S-transferase Mu 5 GSTM5 0.0034
4033 S-formylglutathione hydrolase ESD 0.0034
4038 Glutathione peroxidase 4 GPX4 0.0034
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0034
4042 Glutathione transferase omega-2 GSTO2 0.0034
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0034
6122 Carbonic anhydrase 3 CA3 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
358 Cystathionine beta-synthase CBS 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
3319 Hydroxyacylglutathione hydrolase HAGH 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4031 Glutathione S-transferase A1 GSTA1 0.0031
898 Glutathione S-transferase A3 GSTA3 0.0031
897 Glutathione S-transferase kappa 1 GSTK1 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
914 Formimidoyltransferase-cyclodeaminase FTCD 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
909 Maleylacetoacetate isomerase GSTZ1 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
905 Glutathione transferase omega-1 GSTO1 0.003
899 Glutathione S-transferase Mu 3 GSTM3 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
292 Activin receptor type-1 ACVR1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
6459 Glycodelin PAEP 0.0028
2290 ADP-ribosyl cyclase 2 BST1 0.0028
849 Activated CDC42 kinase 1 TNK2 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
822 Aldose reductase AKR1B1 0.0028
3221 Cytochrome c4 cc4 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
2165 Glutathione S-transferase Mu 2 GSTM2 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0026
207 Glutathione synthetase GSS 0.0026
5269 Glutathione synthetase gshB 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
901 Glutathione S-transferase Mu 4 GSTM4 0.0025
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
3007 Carbonic anhydrase 12 CA12 0.0025
4205 Carbonic anhydrase 9 CA9 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
740 Argininosuccinate synthase ASS1 0.0023
865 Argininosuccinate synthase ASS1 0.0023
2680 Argininosuccinate synthase argG 0.0023
3194 Argininosuccinate synthase argG 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
922 Glutamate receptor 4 GRIA4 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
6021 Adenosine kinase ADK 0.0023
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0022
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0022
4027 Glutamate receptor delta-1 subunit GRID1 0.0022
4018 Glutamate receptor delta-2 subunit GRID2 0.0022
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0022
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0022
1912 Excitatory amino acid transporter 1 SLC1A3 0.0022
664 Glutamate decarboxylase 2 GAD2 0.0022
3890 Glutamate decarboxylase 2 GAD2 0.0022
4016 Excitatory amino acid transporter 5 SLC1A7 0.0022
4019 Excitatory amino acid transporter 4 SLC1A6 0.0022
1047 Excitatory amino acid transporter 2 SLC1A2 0.0022
4026 Aspartyl aminopeptidase DNPEP 0.0022
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0022
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0022
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0022
925 Metabotropic glutamate receptor 4 GRM4 0.0022
926 Metabotropic glutamate receptor 7 GRM7 0.0022
927 Metabotropic glutamate receptor 8 GRM8 0.0022
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0022
4020 Glutamyl aminopeptidase ENPEP 0.0022
4017 5-oxoprolinase OPLAH 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
627 11-cis retinol dehydrogenase RDH5 0.002
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
625 Glutamate carboxypeptidase 2 FOLH1 0.002
1970 Protein kinase C alpha type PRKCA 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
760 Fibroblast growth factor 1 FGF1 0.0019
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0019
5 Glutaminase liver isoform, mitochondrial GLS2 0.0019
917 Glutaminase kidney isoform, mitochondrial GLS 0.0019
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0019
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0019
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0019
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0019
5261 Phosphoribosylformylglycinamidine synthase purL 0.0019
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
665 Phosphoserine aminotransferase PSAT1 0.0019
4652 Phosphoserine aminotransferase serC 0.0019
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0019
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0019
420 Glutamate decarboxylase 1 GAD1 0.0019
3900 Glutamate decarboxylase 1 GAD1 0.0019
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
916 Metabotropic glutamate receptor 1 GRM1 0.0018
4954 Soluble cytochrome b558 Not Available 0.0018
4925 Cytochrome c-type protein SHP shp 0.0018
4934 Cytochrome c-551 nirM 0.0018
5218 Cytochrome c-551 nirM 0.0018
4915 Cytochrome c-550 psbV 0.0018
4959 Cytochrome c-550 psbV 0.0018
5216 Cytochrome c-550 psbV 0.0018
4905 Cytochrome c2 Not Available 0.0018
4939 Cytochrome c2 cycA 0.0018
4964 Cytochrome c2 cycA 0.0018
4979 Cytochrome c2 cycA 0.0018
6673 Cytochrome c2 cycA 0.0018
4947 Bacterial hemoglobin vhb 0.0018
4975 Cytochrome c-556 RPA3973 0.0018
4916 Cyanoglobin glbN 0.0018
4943 Cytochrome c6 petJ 0.0018
4998 Hemoglobin-like protein yjbI yjbI 0.0018
4984 Neuroglobin NGB 0.0018
4936 Cytochrome c2 iso-2 Not Available 0.0018
4994 Hemoglobin-like protein HbO glbO 0.0018
4907 Cytochrome c-L moxG 0.0018
6865 Cytochrome c-L moxG 0.0018
4909 CooA protein cooA 0.0018
4942 Diheme cytochrome c napB napB 0.0018
4910 Cytoglobin CYGB 0.0018
4981 Iron-starvation protein PigA pigA 0.0018
4935 Cytochrome c-554 cycA1 0.0018
5000 HemO hemO 0.0018
4961 Hemophore HasA hasA 0.0018
4971 Nonaheme cytochrome c hmcA 0.0018
4904 Cytochrome c family protein GSU1996 0.0018
4976 Apocytochrome f petA 0.0018
6407 Apocytochrome f petA 0.0018
4989 Cytochrome c551 peroxidase ccp 0.0018
5222 Cytochrome c551 peroxidase ccpA 0.0018
4999 Cytochrome P450 165B3 CYP165B3 0.0018
4764 Cytochrome P450 165C4 CYP165C4 0.0018
4960 Putative cytochrome P450-family protein SCO7417 0.0018
4931 Cytochrome P450 167A1 CYP167A1 0.0018
4926 Heme-based aerotactic transducer hemAT hemAT 0.0018
4937 Cytochrome oxidase subunit II rcoxA 0.0018
4903 Methyl-accepting chemotaxis protein Tar4 0.0018
4993 Hydroxylamine oxidoreductase hao1 0.0018
4972 P450cin cinA 0.0018
4922 Cytochrome c, putative SO_4144 0.0018
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0018
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0018
3093 Catalase HPII katE 0.0018
4952 Catalase/peroxidase katA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1671 Excitatory amino acid transporter 3 SLC1A1 0.0017
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0017
3877 Growth-inhibiting protein 18 GIG18 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0017
426 Aspartate aminotransferase, mitochondrial GOT2 0.0017
763 Tyrosine aminotransferase TAT 0.0016
5493 Tyrosine aminotransferase Not Available 0.0016
4386 Hemoglobin-like protein HbN glbN 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0016
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
6677 Myelin P2 protein PMP2 0.0015
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
810 Heme oxygenase 1 HMOX1 0.0015
3391 Heme oxygenase 1 pbsA1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
4920 Peroxidase/catalase katG 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
2119 Cytochrome b5 CYB5A 0.0013
4990 PpcA ppcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
1507 Cytochrome c CYCS 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0011
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0011
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0011
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0011
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0011
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0011
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0011
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0011
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0011
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0011
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0011
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0011
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0011
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0011
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0011
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0011
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0011
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0011
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0011
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0011
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0011
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0011
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0011
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0011
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0011
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0011
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0011
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
328 Sorbitol dehydrogenase SORD 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
597 Dihydropteridine reductase QDPR 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0009
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0009
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
626 Cysteine dioxygenase type 1 CDO1 0.0009
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0009
12 Alcohol dehydrogenase class 3 ADH5 0.0009
77 L-lactate dehydrogenase B chain LDHB 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
693 Hemoglobin subunit beta HBB 0.0008
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
1867 Major prion protein PRNP 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
279 Tyrosinase TYR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
654 Flavin reductase BLVRB 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
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