DT-Web: DB00755

Identification

Name

Tretinoin

Accession Number

DB00755 (APRD00362, NUTR00051)

Type

small molecule

Description

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

300.4351

Groups

approved

Monoisotopic Weight

300.20893014

Pharmacology

Indication

For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Mechanism of action

Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

Absorption

1-31% (topical)

Protein binding

> 95%

Biotransformation

Hepatic

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	The strong CYP2C8 inhibitor, Atazanavir, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Atazanavir is initiated, discontinued to dose changed.
Carbamazepine	The strong CYP2C8 inducer, Carbamazepine, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Carbamazepine is initiated, discontinued or dose changed.
Celecoxib	The moderate CYP2C8 inhibitor, Celecoxib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Celecoxib is initiated, discontinued to dose changed.
Demeclocycline	Demeclocycline may increase the adverse effects of oral Tretinoin. Increased risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Desogestrel	Oral Tretinoin may decrease the effect of oral contraceptive, Desogestrel. An alternate form of contraception should be used during concomitant therapy.
Doxycycline	Doxycycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Drospirenone	Oral Tretinoin may decrease the effect of oral contraceptive, Drospirenone. An alternate form of contraception should be used during concomitant therapy.
Eltrombopag	The moderate CYP2C8 inhibitor, Eltrombopag, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Eltrombopag is initiated, discontinued or dose changed.
Ethinyl Estradiol	Oral Tretinoin may decrease the effect of the oral contraceptive, Ethinyl Estradiol. An alternate form of contraception should be used during concomitant therapy.
Ethynodiol Diacetate	Oral Tretinoin may decrease the effect of oral contraceptive, Ethynodiol Diacetate. An alternate form of contraception should be used during concomitant therapy.
Etonogestrel	Oral Tretinoin may decrease the effect of oral contraceptive, Etonogestrel. An alternate form of contraception should be used during concomitant therapy.
Felodipine	The moderate CYP2C8 inhibitor, Felopidine, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Felopidine is initiated, discontinued to dose changed.
Fosphenytoin	The strong CYP2C8 inducer, Fosphenytoin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Fosphenytoin is initiated, discontinued or dose changed.
Gemfibrozil	The strong CYP2C8 inhibitor, Gemfibrozil, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Gemfibrozil is initiated, discontinued to dose changed.
Irbesartan	The moderate CYP2C8 inhibitor, Irbesartan, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Irbesartan is initiated, discontinued to dose changed.
Lapatinib	The moderate CYP2C8 inhibitor, Lapatinib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Lapatinib is initiated, discontinued to dose changed.
Levonorgestrel	Oral Tretinoin may decrease the effect of oral contraceptive, Levonorgestrel. An alternate form of contraception should be used during concomitant therapy.
Losartan	The moderate CYP2C8 inhibitor, Losartan, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Losartan is initiated, discontinued to dose changed.
Mestranol	Oral Tretinoin may decrease the effect of oral contraceptive, Mestranol. An alternate form of contraception should be used during concomitant therapy.
Minocycline	Minocycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Natalizumab	Oral tretinoin may increase the adverse/toxic effects of Natalizumab. Concurrent therapy should be avoided.
Nilotinib	The moderate CYP2C8 inhibitor, Nilotinib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Nilotinib is initiated, discontinued to dose changed.
Norethindrone	Oral Tretinoin may decrease the effect of oral contraceptive, Norethindrone. An alternate form of contraception should be used during concomitant therapy.
Norgestimate	Oral Tretinoin may decrease the effect of oral contraceptive, Norgestimate. An alternate form of contraception should be used during concomitant therapy.
Oxytetracycline	Oxytetracycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Phenobarbital	The strong CYP2C8 inducer, Phenobarbital, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Phenobarbital is initiated, discontinued or dose changed.
Phenytoin	The strong CYP2C8 inducer, Phenytoin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Phenytoin is initiated, discontinued or dose changed.
Pioglitazone	The moderate CYP2C8 inhibitor, Pioglitazone, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Pioglitazone is initiated, discontinued to dose changed.
Primidone	The strong CYP2C8 inducer, Primidone, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Primidone is initiated, discontinued or dose changed.
Quinine	The moderate CYP2C8 inhibitor, Quinine, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Quinine is initiated, discontinued to dose changed.
Rabeprazole	The moderate CYP2C8 inhibitor, Rabaprazole, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rabaprazole is initiated, discontinued to dose changed.
Rifampin	The strong CYP2C8 inducer, Rifampin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rifampin is initiated, discontinued or dose changed.
Rifapentine	The strong CYP2C8 inducer, Rifapentine, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rifapentine is initiated, discontinued or dose changed.
Ritonavir	The strong CYP2C8 inhibitor, Ritonavir, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Ritonavir is initiated, discontinued to dose changed.
Rosiglitazone	The moderate CYP2C8 inhibitor, Rosiglitazone, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rosiglitazone is initiated, discontinued to dose changed.
Secobarbital	The strong CYP2C8 inducer, Secobarbital, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Secobarbital is initiated, discontinued or dose changed.
Sorafenib	The strong CYP2C8 inhibitor, Sorafenib, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Sorafenib is initiated, discontinued to dose changed.
Tamoxifen	The moderate CYP2C8 inhibitor, Tamoxifen, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Tamoxifen is initiated, discontinued to dose changed.
Tetracycline	Demeclocycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Tigecycline	Demeclocycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Trastuzumab	Increased risk of leukopenia and anemia due to synergistic effects. Monitor for signs and symptoms of adverse events during concomitant therapy.
Trimethoprim	The moderate CYP2C8 inhibitor, Trimethoprim, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Trimethoprim is initiated, discontinued to dose changed.
Vitamin A	Tretinoin increases the risk of vitamin A toxicity. Avoid vitamin A supplementation while taking systemic tretinoin.

Food Interactions

Not Available

Retinoic acid receptor RXR-beta
Name	Retinoic acid receptor RXR-beta
Gene Name	RXRB
Pharmacological action	yes
Actions	agonist
References	Stafslien DK, Vedvik KL, De Rosier T, Ozers MS: Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):82-9. Epub 2006 Dec 20. - Pubmed Redfern CP: Enhancing enhancers: new complexities in the retinoid regulation of gene expression. Biochem J. 2004 Oct 1;383(Pt 1):e1-2. - Pubmed Nagasawa H, Takahashi S, Kobayashi A, Tazawa H, Tashima Y, Sato K: Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells. J Nutr Sci Vitaminol (Tokyo). 2005 Oct;51(5):311-8. - Pubmed Schrage K, Koopmans G, Joosten EA, Mey J: Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury. Eur J Neurosci. 2006 Jan;23(2):285-95. - Pubmed Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H: Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact. 2005 Sep 10;156(1):25-39. - Pubmed
DTHybrid score	0.8635
Retinoic acid receptor RXR-gamma
Name	Retinoic acid receptor RXR-gamma
Gene Name	RXRG
Pharmacological action	yes
Actions	agonist
References	Koda T, Imai H, Morita M: Antiestrogenic activity of vitamin A in in vivo uterotrophic assay. Life Sci. 2007 Feb 13;80(10):945-9. Epub 2006 Nov 22. - Pubmed He JC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, Klotman PE: Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol. 2007 Jan;18(1):93-102. Epub 2006 Dec 20. - Pubmed Day RM, Lee YH, Park AM, Suzuki YJ: Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol. 2006 Jun;34(6):695-703. Epub 2006 Feb 2. - Pubmed Schrage K, Koopmans G, Joosten EA, Mey J: Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury. Eur J Neurosci. 2006 Jan;23(2):285-95. - Pubmed Wang J, Yen A: A novel retinoic acid-responsive element regulates retinoic acid-induced BLR1 expression. Mol Cell Biol. 2004 Mar;24(6):2423-43. - Pubmed
DTHybrid score	0.6278
Retinoic acid receptor gamma-1
Name	Retinoic acid receptor gamma-1
Gene Name	RARG
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Reddy AP, Chen JY, Zacharewski T, Gronemeyer H, Voorhees JJ, Fisher GJ: Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system. Biochem J. 1992 Nov 1;287 ( Pt 3):833-40. - Pubmed Kamei Y, Kawada T, Kazuki R, Sugimoto E: Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. Biochem J. 1993 Aug 1;293 ( Pt 3):807-12. - Pubmed Borger DR, Mi Y, Geslani G, Zyzak LL, Batova A, Engin TS, Pirisi L, Creek KE: Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta. Virology. 2000 May 10;270(2):397-407. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.3604
Retinal dehydrogenase 1
Name	Retinal dehydrogenase 1
Gene Name	ALDH1A1
Pharmacological action	unknown
Actions	Not Available
References	Mic FA, Molotkov A, Molotkova N, Duester G: Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation. Dev Dyn. 2004 Oct;231(2):270-7. - Pubmed Everts HB, King LE Jr, Sundberg JP, Ong DE: Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation. J Invest Dermatol. 2004 Aug;123(2):258-63. - Pubmed Gidlof AC, Ocaya P, Olofsson PS, Torma H, Sirsjo A: Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells. J Vasc Res. 2006;43(4):392-8. Epub 2006 Jul 6. - Pubmed Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB: Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 2005 Nov;132(21):4789-800. Epub 2005 Oct 5. - Pubmed Kim H, Lapointe J, Kaygusuz G, Ong DE, Li C, van de Rijn M, Brooks JD, Pollack JR: The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer. Cancer Res. 2005 Sep 15;65(18):8118-24. - Pubmed
DTHybrid score	0.2926
Retinoic acid-induced protein 3
Name	Retinoic acid-induced protein 3
Gene Name	GPRC5A
Pharmacological action	unknown
Actions	Not Available
References	Xu J, Tian J, Shapiro SD: Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Am J Respir Cell Mol Biol. 2005 May;32(5):381-7. Epub 2005 Jan 27. - Pubmed Inoue S, Nambu T, Shimomura T: The RAIG family member, GPRC5D, is associated with hard-keratinized structures. J Invest Dermatol. 2004 Mar;122(3):565-73. - Pubmed
DTHybrid score	0.3646
Nuclear receptor 0B1
Name	Nuclear receptor 0B1
Gene Name	NR0B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.3201
Retinal dehydrogenase 2
Name	Retinal dehydrogenase 2
Gene Name	ALDH1A2
Pharmacological action	unknown
Actions	Not Available
References	Mic FA, Sirbu IO, Duester G: Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. J Biol Chem. 2004 Jun 18;279(25):26698-706. Epub 2004 Apr 6. - Pubmed Bordelon T, Montegudo SK, Pakhomova S, Oldham ML, Newcomer ME: A disorder to order transition accompanies catalysis in retinaldehyde dehydrogenase type II. J Biol Chem. 2004 Oct 8;279(41):43085-91. Epub 2004 Aug 7. - Pubmed Mic FA, Molotkov A, Molotkova N, Duester G: Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation. Dev Dyn. 2004 Oct;231(2):270-7. - Pubmed Doxakis E, Davies AM: Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons. Mol Cell Neurosci. 2005 Aug;29(4):617-27. - Pubmed Everts HB, Sundberg JP, Ong DE: Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Exp Cell Res. 2005 Aug 15;308(2):309-19. - Pubmed
DTHybrid score	0.3036
Retinoic acid receptor responder protein 1
Name	Retinoic acid receptor responder protein 1
Gene Name	RARRES1
Pharmacological action	unknown
Actions	agonist
References	Youssef EM, Chen XQ, Higuchi E, Kondo Y, Garcia-Manero G, Lotan R, Issa JP: Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Cancer Res. 2004 Apr 1;64(7):2411-7. - Pubmed Zirn B, Samans B, Spangenberg C, Graf N, Eilers M, Gessler M: All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo. Oncogene. 2005 Aug 4;24(33):5246-51. - Pubmed
DTHybrid score	0.3646

Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.4594
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.5036
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.5603
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.6727
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.8818
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.5545
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.4835
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.3735
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.4362
Cytochrome P450 4A11
Name	Cytochrome P450 4A11
Gene Name	CYP4A11
Actions	substrate
References	Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. - Pubmed
DTHybrid score	0.319

Cellular retinoic acid-binding protein 1
Name	Cellular retinoic acid-binding protein 1
Gene Name	CRABP1
Actions	substrate
References	Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H: Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact. 2005 Sep 10;156(1):25-39. - Pubmed Donato LJ, Noy N: Fluorescence-based technique for analyzing retinoic acid. Methods Mol Biol. 2010;652:177-87. - Pubmed
DTHybrid score	0.8787
Cellular retinoic acid-binding protein 2
Name	Cellular retinoic acid-binding protein 2
Gene Name	CRABP2
Actions	substrate
References	Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H: Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact. 2005 Sep 10;156(1):25-39. - Pubmed Ohnishi K: PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. Int J Clin Oncol. 2007 Oct;12(5):313-7. Epub 2007 Oct 22. - Pubmed Donato LJ, Noy N: Fluorescence-based technique for analyzing retinoic acid. Methods Mol Biol. 2010;652:177-87. - Pubmed
DTHybrid score	1.4166

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.4208
4200	Cytochrome P450 1A2	CYP1A2	0.41
4119	Cytochrome P450 2D6	CYP2D6	0.3988
1588	Multidrug resistance protein 1	ABCB1	0.3716
229	Retinoic acid receptor beta	RARB	0.3524
730	Retinoic acid receptor alpha	RARA	0.3513
459	Retinoic acid receptor RXR-alpha	RXRA	0.346
6013	Cytochrome P450 2E1	CYP2E1	0.2354
5934	Cytochrome P450 26A1	CYP26A1	0.1733
6283	Oxysterols receptor LXR-alpha	NR1H3	0.1452
587	Serum albumin	ALB	0.1315
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.128
3811	Cytochrome P450 19A1	CYP19A1	0.1261
20	Prostaglandin G/H synthase 1	PTGS1	0.1157
1898	Cytochrome P450 1B1	CYP1B1	0.1031
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0964
331	Retinol-binding protein I, cellular	RBP1	0.0957
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0859
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0785
776	Bile salt export pump	ABCB11	0.0693
6031	Cytochrome P450 3A43	CYP3A43	0.0683
862	Multidrug resistance-associated protein 1	ABCC1	0.0662
492	Histamine H1 receptor	HRH1	0.0626
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0612
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0599
1729	Solute carrier family 22 member 6	SLC22A6	0.0596
871	Glucocorticoid receptor	NR3C1	0.0574
290	Prostaglandin G/H synthase 2	PTGS2	0.0564
824	Sodium-dependent serotonin transporter	SLC6A4	0.0556
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0539
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0534
6241	Nuclear receptor coactivator 2	NCOA2	0.0507
6145	Solute carrier family 22 member 1	SLC22A1	0.0483
6144	Solute carrier family 22 member 2	SLC22A2	0.0481
847	Mu-type opioid receptor	OPRM1	0.0476
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0474
136	Estrogen receptor	ESR1	0.0468
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0462
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.046
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.045
380	Cytochrome P450 17A1	CYP17A1	0.0443
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0428
561	Retinol-binding protein II, cellular	RBP2	0.0413
589	Retinoid-binding protein 7	RBP7	0.0413
753	Retinol-binding protein III, cellular	RBP5	0.0413
1097	Lecithin retinol acyltransferase	LRAT	0.0413
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0413
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0413
651	Retinol dehydrogenase 13	RDH13	0.0413
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0413
4073	Retinol dehydrogenase 11	RDH11	0.0413
863	Cellular retinaldehyde-binding protein	RLBP1	0.0413
4074	Retinol dehydrogenase 14	RDH14	0.0413
800	Retinol dehydrogenase 12	RDH12	0.0413
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0413
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0412
627	11-cis retinol dehydrogenase	RDH5	0.0403
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0398
118	Organic cation/carnitine transporter 2	SLC22A5	0.0388
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0386
85	Growth hormone receptor	GHR	0.0385
469	Annexin A1	ANXA1	0.0379
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0379
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0379
831	D(2) dopamine receptor	DRD2	0.0368
467	Delta-type opioid receptor	OPRD1	0.0367
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0364
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0363
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0362
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0361
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0357
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.035
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.035
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0348
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0347
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0346
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0345
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0342
6143	Solute carrier family 22 member 7	SLC22A7	0.0342
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0339
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0337
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0337
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.033
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0329
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0326
2164	Multidrug resistance-associated protein 4	ABCC4	0.0325
6142	Solute carrier family 22 member 8	SLC22A8	0.0322
696	Kappa-type opioid receptor	OPRK1	0.0321
556	Alpha-1A adrenergic receptor	ADRA1A	0.032
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.032
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0318
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0313
6147	Solute carrier family 22 member 3	SLC22A3	0.0312
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0298
260	Cytochrome P450 51	ERG11	0.0295
761	Cytochrome P450 51	ERG11	0.0295
3163	Cytochrome P450 51	cyp51	0.0295
731	HIV-1 protease	HIV-1 protease	0.0295
345	Plasma retinol-binding protein	RBP4	0.0293
766	Beta-2 adrenergic receptor	ADRB2	0.0293
465	Calmodulin	CALM1	0.0287
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0282
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0279
713	Sodium-dependent dopamine transporter	SLC6A3	0.0275
318	Alpha-2A adrenergic receptor	ADRA2A	0.0275
3932	Glutathione S-transferase A2	GSTA2	0.027
3923	Cholinesterase	BCHE	0.0267
6014	Cytochrome P450 2A13	CYP2A13	0.0265
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0258
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0254
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0254
6136	Multidrug resistance-associated protein 5	ABCC5	0.0249
251	Alcohol dehydrogenase 1A	ADH1A	0.0242
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0236
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0236
6182	Cytochrome P450 2J2	CYP2J2	0.0235
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0234
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0229
3426	Glutamine synthetase	glnA	0.0227
3987	Glutamine synthetase	GLUL	0.0227
833	Organic cation/carnitine transporter 1	SLC22A4	0.0226
122	P2Y purinoceptor 12	P2RY12	0.0225
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0225
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0223
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0223
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0221
811	Translocator protein	TSPO	0.0218
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0217
844	Epidermal growth factor receptor	EGFR	0.0215
23	D(1A) dopamine receptor	DRD1	0.0215
444	Alcohol dehydrogenase 1B	ADH1B	0.0214
614	Progesterone receptor	PGR	0.0212
6102	Arylamine N-acetyltransferase 2	NAT2	0.0211
891	Dihydropteroate synthase	folP	0.021
5359	Dihydropteroate synthase	folP	0.021
7175	Dihydropteroate synthase	sulI	0.021
6148	Multidrug resistance-associated protein 7	ABCC10	0.0209
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0207
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0207
482	Glycine receptor subunit alpha-1	GLRA1	0.0207
632	Alpha-1B adrenergic receptor	ADRA1B	0.0202
4311	tRNA	TRDMT1	0.0202
4325	tRNA	trmD	0.0202
4328	tRNA	trmD	0.0202
7	Nitric oxide synthase, inducible	NOS2	0.0201
638	D(3) dopamine receptor	DRD3	0.0199
3941	Amine oxidase [flavin-containing] A	MAOA	0.0196
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0195
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0193
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0192
737	Mineralocorticoid receptor	NR3C2	0.0191
817	DNA topoisomerase 2-alpha	TOP2A	0.0188
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0186
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0185
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0185
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0185
146	Androgen receptor	AR	0.0185
517	Alcohol dehydrogenase 1C	ADH1C	0.0184
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0183
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0183
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0182
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0182
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0182
1757	Myeloperoxidase	MPO	0.0182
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0181
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.018
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0179
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0177
3191	Histidinol dehydrogenase	hisD	0.0176
232	Corticosteroid-binding globulin	SERPINA6	0.0176
1024	Solute carrier family 22 member 11	SLC22A11	0.0174
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0173
6228	Nuclear receptor coactivator 1	NCOA1	0.0172
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0171
6137	Multidrug resistance-associated protein 6	ABCC6	0.0171
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.017
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.017
504	Mast/stem cell growth factor receptor	KIT	0.0169
193	Beta-1 adrenergic receptor	ADRB1	0.0169
756	Sex hormone-binding globulin	SHBG	0.0167
1010	Cytochrome P450 51A1	CYP51A1	0.0166
6020	Aldehyde oxidase	AOX1	0.0163
5669	50S ribosomal protein L27	rpmA	0.0161
5670	Organic hydroperoxide resistance protein	ohr	0.0161
777	Tumor necrosis factor	TNF	0.0161
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0161
5675	Chaperone protein torD	torD	0.0161
5410	Unsaturated glucuronyl hydrolase	ugl	0.0161
5673	C protein alpha-antigen	bca	0.0161
5676	Axin-1	AXIN1	0.0161
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0159
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0159
3939	Amine oxidase [flavin-containing] B	MAOB	0.0157
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0155
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0154
6220	Aryl hydrocarbon receptor	AHR	0.0152
3947	Xanthine dehydrogenase/oxidase	XDH	0.0152
705	Glutamate receptor 1	GRIA1	0.0151
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0149
4120	NADPH--cytochrome P450 reductase	POR	0.0147
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0145
820	Glycine receptor subunit alpha-2	GLRA2	0.0145
2636	Shikimate dehydrogenase	aroE	0.0145
3515	Shikimate dehydrogenase	aroE	0.0145
4604	Liver carboxylesterase 1	CES1	0.0144
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0144
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0144
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0144
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0144
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0143
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0142
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0142
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0142
6174	50S ribosomal protein L32	rpmF	0.0142
29	Tubulin beta-1 chain	TUBB1	0.0142
869	Estrogen receptor beta	ESR2	0.0141
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0141
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0137
6141	Sodium/bile acid cotransporter	SLC10A1	0.0136
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0135
191	Peptide methionine sulfoxide reductase	MSRA	0.0134
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0134
789	Alpha-1D adrenergic receptor	ADRA1D	0.0134
909	Maleylacetoacetate isomerase	GSTZ1	0.0134
70	Type-1 angiotensin II receptor	AGTR1	0.0133
94	5-hydroxytryptamine 4 receptor	HTR4	0.0132
4811	Amylosucrase	ams	0.0131
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.013
921	Glutamate receptor 2	GRIA2	0.0129
2280	Listeriolysin regulatory protein	prfA	0.0129
378	Alpha-2C adrenergic receptor	ADRA2C	0.0129
275	Arachidonate 5-lipoxygenase	ALOX5	0.0128
818	50S ribosomal protein L10	rplJ	0.0128
629	Alpha-2B adrenergic receptor	ADRA2B	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
427	Substance-P receptor	TACR1	0.0126
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0125
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0124
407	Vascular endothelial growth factor receptor 2	KDR	0.0123
4237	50S ribosomal protein L22	rplV	0.0123
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0122
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0122
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0122
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0122
816	Biliverdin reductase A	BLVRA	0.0122
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0122
716	5-hydroxytryptamine 7 receptor	HTR7	0.012
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0116
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0116
48	Pyridoxal kinase	PDXK	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0114
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0114
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0113
4238	50S ribosomal protein L4	rplD	0.0113
5578	50S ribosomal protein L4	rplD	0.0113
6173	50S ribosomal protein L4	rplD	0.0113
6219	50S ribosomal protein L4	rplD	0.0113
26	Vascular endothelial growth factor receptor 3	FLT4	0.0112
284	DNA-directed RNA polymerase beta chain	rpoB	0.0112
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0112
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0111
295	Carbonic anhydrase 1	CA1	0.011
477	DNA topoisomerase 4 subunit A	parC	0.011
886	DNA topoisomerase 4 subunit A	parC	0.011
6226	DNA topoisomerase 4 subunit A	parC	0.011
174	Sigma 1-type opioid receptor	SIGMAR1	0.0109
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0109
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
365	Dihydrofolate reductase	DHFR	0.0108
2381	Dihydrofolate reductase	DFR1	0.0108
2833	Dihydrofolate reductase	Not Available	0.0108
2931	Dihydrofolate reductase	folA	0.0108
3544	Dihydrofolate reductase	folA	0.0108
3682	Dihydrofolate reductase	folA	0.0108
6642	Dihydrofolate reductase	folA	0.0108
6756	Dihydrofolate reductase	dfrA	0.0108
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0108
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0107
32	Vascular endothelial growth factor receptor 1	FLT1	0.0107
6146	High affinity copper uptake protein 1	SLC31A1	0.0107
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0107
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0107
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0107
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0107
432	D(4) dopamine receptor	DRD4	0.0106
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0106
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0106
396	Alcohol dehydrogenase 4	ADH4	0.0106
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0106
597	Dihydropteridine reductase	QDPR	0.0105
328	Sorbitol dehydrogenase	SORD	0.0105
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0105
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0104
3808	Dihydropteroate synthase 2	folP2	0.0103
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0103
3601	Dihydropteroate synthase 1	folP1	0.0103
3807	Dihydropteroate synthase 1	folP1	0.0103
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0103
1656	CYP2B protein	CYP2B	0.0102
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0101
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0101
4203	Histamine N-methyltransferase	HNMT	0.0101
68	Cannabinoid receptor 1	CNR1	0.01
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.01
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.01
2314	Triosephosphate isomerase	TPI	0.0099
3417	Triosephosphate isomerase	tpiA	0.0099
3443	Triosephosphate isomerase	tpiA	0.0099
6346	Triosephosphate isomerase	TPI1	0.0099
473	L-lactate dehydrogenase A chain	LDHA	0.0099
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0098
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0098
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0098
2499	Tubulin beta-2C chain	TUBB2C	0.0098
373	Transthyretin	TTR	0.0098
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0097
77	L-lactate dehydrogenase B chain	LDHB	0.0096
12	Alcohol dehydrogenase class 3	ADH5	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
952	Dipeptidyl peptidase 4	DPP4	0.0096
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0095
1192	Sulfotransferase 1A1	SULT1A1	0.0095
1517	Beta-3 adrenergic receptor	ADRB3	0.0095
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0094
2449	Tubulin alpha-3 chain	TUBA1A	0.0094
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0092
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0092
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0092
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0092
1050	Bile salt sulfotransferase	SULT2A1	0.0092
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0092
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0092
738	Monocarboxylate transporter 1	SLC16A1	0.0091
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0091
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0091
6085	Fatty acid-binding protein, intestinal	FABP2	0.009
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.009
613	Atrial natriuretic peptide receptor A	NPR1	0.009
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.009
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0089
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
161	Tubulin beta chain	TUBB	0.0088
312	Tubulin beta chain	TUB2	0.0088
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0087
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0087
814	Ryanodine receptor 1	RYR1	0.0086
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0086
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0086
908	Glutathione S-transferase theta-1	GSTT1	0.0085
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0084
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0084
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0083
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0083
768	FK506-binding protein 1A	FKBP1A	0.0083
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0082
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0079
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0079
3809	Estrogen-related receptor gamma	ESRRG	0.0079
823	Fibroblast growth factor receptor 2	FGFR2	0.0078
2230	Catalase	CAT	0.0078
3249	Catalase	katA	0.0078
3625	Catalase	katA	0.0078
4539	Catalase	katA	0.0078
4941	Catalase	katB	0.0078
16	Adenosine A1 receptor	ADORA1	0.0078
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0078
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0078
723	Cytosolic phospholipase A2	PLA2G4A	0.0077
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0077
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0077
54	Prothrombin	F2	0.0076
6163	Copper-transporting ATPase 2	ATP7B	0.0076
6165	Copper-transporting ATPase 1	ATP7A	0.0076
1178	Adenosine A2a receptor	ADORA2A	0.0076
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0076
165	FL cytokine receptor	FLT3	0.0076
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0076
904	Glutathione S-transferase P	GSTP1	0.0075
592	Carbonic anhydrase 4	CA4	0.0075
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0075
106	Cannabinoid receptor 2	CNR2	0.0075
3810	Catechol O-methyltransferase	COMT	0.0074
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0074
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0074
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0074
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0074
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0074
1541	Metalloproteinase	mmp20	0.0074
518	Peroxidase/catalase T	katG	0.0073
2539	Tubulin alpha-1 chain	TUBA4A	0.0073
131	Synaptic vesicular amine transporter	SLC18A2	0.0073
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0073
4423	Levodione reductase	lvr	0.0073
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0073
4428	Redox-sensing transcriptional repressor rex	rex	0.0073
4449	ADP-ribosyltransferase	Not Available	0.0073
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0073
4435	L-aspartate dehydrogenase	nadX	0.0073
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0073
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0073
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0073
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0073
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0073
3729	Citrate synthase	gltA	0.0073
4575	Citrate synthase	cit	0.0073
4580	Citrate synthase	gltA	0.0073
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0073
2350	3-isopropylmalate dehydrogenase	leuB	0.0073
3092	3-isopropylmalate dehydrogenase	leuB	0.0073
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0073
4500	L-lactate dehydrogenase 2	ldh2	0.0073
4443	Quinate/shikimate dehydrogenase	ydiB	0.0073
4502	Formate dehydrogenase	Not Available	0.0073
4447	Hypothetical protein yhfP	yhfP	0.0073
3381	Alcohol dehydrogenase	Not Available	0.0073
4508	Alcohol dehydrogenase	adhA	0.0073
4414	Dehydrogenase	TT_P0035	0.0073
4418	AGR_L_3209p	AGR_L_3209	0.0073
4497	Benzyl alcohol dehydrogenase	xylB	0.0073
4455	Glycerol dehydrogenase	gldA	0.0073
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0073
4507	Alanine dehydrogenase	ald	0.0073
4451	Vip2Ac	vip2Ac	0.0073
4472	Glucose 1-dehydrogenase	Not Available	0.0073
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0073
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0073
4487	Transcriptional regulator nadR	nadR	0.0073
4467	Alpha-glucosidase, putative	TM_0752	0.0073
6432	Transporter	snf	0.0072
856	Vitamin D3 receptor	VDR	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
239	Coagulation factor X	F10	0.0072
3937	Fatty-acid amide hydrolase	FAAH	0.0071
2112	Toll-like receptor 9	TLR9	0.0071
1275	Estrogen sulfotransferase	SULT1E1	0.0071
124	Histamine H2 receptor	HRH2	0.0071
714	Glutathione reductase, mitochondrial	GSR	0.007
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.007
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.007
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.007
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0069
49	Endothelin B receptor	EDNRB	0.0069
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0069
1039	Histone deacetylase 9	HDAC9	0.0068
33	Cystine/glutamate transporter	SLC7A11	0.0068
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0068
581	Cytochrome P450 2R1	CYP2R1	0.0068
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0068
896	Glutathione S-transferase Mu 1	GSTM1	0.0067
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0067
1196	Complement decay-accelerating factor	CD55	0.0067
24	Thymidylate synthase	TMP1	0.0066
359	Thymidylate synthase	TYMS	0.0066
2626	Thymidylate synthase	thyA	0.0066
2729	Thymidylate synthase	thyA	0.0066
5352	Thymidylate synthase	THYA	0.0066
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0066
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0066
1852	Microtubule-associated protein 2	MAP2	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0065
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0065
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0065
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0065
4122	Histone deacetylase 2	HDAC2	0.0065
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0065
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0065
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0065
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0065
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0065
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0065
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0065
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0065
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0065
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0065
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0065
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0065
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0065
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0065
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0065
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0065
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0065
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0065
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0065
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0065
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0065
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0065
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0065
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0065
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0065
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0065
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0065
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0065
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0065
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0065
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0065
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0065
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0065
729	GDP-L-fucose synthetase	TSTA3	0.0065
3463	GDP-L-fucose synthetase	fcl	0.0065
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0065
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0065
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0065
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0065
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0065
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0065
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0065
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0065
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0065
167	L-lactate dehydrogenase C chain	LDHC	0.0065
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0065
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0065
206	3-keto-steroid reductase	HSD17B7	0.0065
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0065
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0065
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0065
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0065
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0065
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0065
107	C-4 methylsterol oxidase	SC4MOL	0.0065
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0065
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0065
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0065
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0065
644	Heme oxygenase 2	HMOX2	0.0065
4982	Heme oxygenase 2	pbsA2	0.0065
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0065
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0065
34	7-dehydrocholesterol reductase	DHCR7	0.0065
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0065
711	UDP-glucose 6-dehydrogenase	UGDH	0.0065
3672	UDP-glucose 6-dehydrogenase	hasB	0.0065
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0065
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0065
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0065
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0065
643	Peroxisomal bifunctional enzyme	EHHADH	0.0065
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0065
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0065
563	Thyroid peroxidase	TPO	0.0064
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0063
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0063
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0063
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0063
133	Dihydropterate synthase	sulI	0.0063
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0063
273	Apoptosis regulator Bcl-2	BCL2	0.0063
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0062
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0062
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
976	Platelet glycoprotein IX	GP9	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
319	Opioid receptor, sigma 1	OPRS1	0.0061
5923	Microtubule-associated protein tau	MAPT	0.006
5924	Microtubule-associated protein 4	MAP4	0.006
1618	High affinity nerve growth factor receptor	NTRK1	0.006
1629	Transcription factor AP-1	JUN	0.006
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.006
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.006
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0059
5300	Antigen peptide transporter 1	TAP1	0.0059
1483	Membrane copper amine oxidase	AOC3	0.0059
6138	Multidrug resistance protein 3	ABCB4	0.0058
2808	Chloramphenicol acetyltransferase 3	cat3	0.0058
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0058
1630	Integrin beta-2	ITGB2	0.0058
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0058
790	DNA polymerase subunit alpha B	POLA2	0.0058
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0056
666	NADP-dependent malic enzyme	ME1	0.0056
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0056
357	Carbonic anhydrase 2	CA2	0.0056
4486	Phenol 2-hydroxylase component B	pheA2	0.0056
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0056
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0056
5117	Dihydrolipoyl dehydrogenase	lpd	0.0056
4439	Ferredoxin reductase	bphA4	0.0056
4427	TDP-glucose-4,6-dehydratase	desIV	0.0056
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0056
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0056
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0056
2967	CDP-paratose 2-epimerase	rfbE	0.0056
4482	UDP-galactose 4-epimerase	galE	0.0056
4503	NADPH-flavin oxidoreductase	frp	0.0055
3081	3-dehydroquinate synthase	aroB	0.0055
2507	Diphtheria toxin	Not Available	0.0055
267	Plasminogen activator inhibitor 1	SERPINE1	0.0055
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0055
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0055
2591	Urocanate hydratase	hutU	0.0055
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0055
2538	6-phospho-beta-glucosidase bglT	bglT	0.0055
2393	Maltose-6'-phosphate glucosidase	glvA	0.0055
4450	Iota toxin component Ia	Not Available	0.0055
4509	Acetoin(diacetyl) reductase	budC	0.0055
126	D-lactate dehydrogenase	dld	0.0055
3545	D-lactate dehydrogenase	Not Available	0.0055
4510	D-lactate dehydrogenase	ldhA	0.0055
2424	L-lactate dehydrogenase	ldh	0.0055
2641	L-lactate dehydrogenase	Not Available	0.0055
4437	L-lactate dehydrogenase	ldh	0.0055
4442	L-lactate dehydrogenase	ldh	0.0055
3615	Dihydrodipicolinate reductase	dapB	0.0055
3618	Dihydrodipicolinate reductase	dapB	0.0055
4462	Dihydrodipicolinate reductase	dapB	0.0055
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0055
4496	C-terminal-binding protein 1	CTBP1	0.0055
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0055
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0055
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0055
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0055
857	Malate dehydrogenase, mitochondrial	MDH2	0.0055
4498	Ornithine cyclodeaminase	PP3533	0.0055
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0055
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0054
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0054
6026	Alcohol dehydrogenase 6	ADH6	0.0054
2018	Deoxyhypusine synthase	DHPS	0.0054
1992	Vitamin D-binding protein	GC	0.0054
4228	Keratin, type II cytoskeletal 7	KRT7	0.0054
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0054
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0054
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0054
626	Cysteine dioxygenase type 1	CDO1	0.0054
4476	Mannitol dehydrogenase	mtlD	0.0054
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0054
3086	Plasmepsin-2	Not Available	0.0053
63	Malate dehydrogenase	mdh	0.0053
2329	Malate dehydrogenase	mdh	0.0053
3445	Malate dehydrogenase	mdh	0.0053
4420	Malate dehydrogenase	mdh	0.0053
4438	Malate dehydrogenase	mdh	0.0053
2417	Chloramphenicol acetyltransferase	cat	0.0053
3278	Chloramphenicol acetyltransferase	cat	0.0053
2683	Mono-ADP-ribosyltransferase C3	C3	0.0053
2810	Dr hemagglutinin structural subunit	draA	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
571	Melatonin receptor type 1A	MTNR1A	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0052
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0052
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0051
153	Dopamine beta-hydroxylase	DBH	0.0051
2981	Phospholipase A2, membrane associated	PLA2G2A	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
163	D(1B) dopamine receptor	DRD5	0.005
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.005
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.005
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.005
13	Aminomethyltransferase, mitochondrial	AMT	0.0049
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0049
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0049
6221	Steroid hormone receptor ERR1	ESRRA	0.0049
4504	WbpP	Not Available	0.0049
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0049
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0049
3367	GDP-mannose 6-dehydrogenase	algD	0.0049
4440	NADH peroxidase	npr	0.0049
4318	Siroheme synthase	cysG	0.0048
6126	Carbonic anhydrase 7	CA7	0.0048
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0048
810	Heme oxygenase 1	HMOX1	0.0048
3391	Heme oxygenase 1	pbsA1	0.0048
4343	Alpha-glucosidase	aglA	0.0048
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0048
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0048
327	Glutathione reductase	gor	0.0048
5110	Glutathione reductase	GR2	0.0048
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0048
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0048
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0048
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0048
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0047
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0047
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0047
822	Aldose reductase	AKR1B1	0.0047
1648	Elastin	ELN	0.0046
1714	Mitogen-activated protein kinase 3	MAPK3	0.0046
183	Vascular endothelial growth factor A	VEGFA	0.0046
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0046
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0046
279	Tyrosinase	TYR	0.0045
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0045
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0045
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0045
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0045
2826	Glucose--fructose oxidoreductase	gfo	0.0045
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0045
3070	Adenosylhomocysteinase	AHCY	0.0045
4424	Adenosylhomocysteinase	PFE1050w	0.0045
6278	Adenosylhomocysteinase	ahcY	0.0045
936	Ephrin type-A receptor 2	EPHA2	0.0045
474	Acetylcholinesterase	ACHE	0.0045
2298	Cytochrome P450-cam	camC	0.0045
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0044
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0044
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0044
4773	Deoxycytidine kinase	DCK	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0043
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0043
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0043
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0042
654	Flavin reductase	BLVRB	0.0042
3913	Glutamic acid decarboxylase	GAD65	0.0042
751	Potassium channel subfamily K member 6	KCNK6	0.0042
5787	Angiopoietin-1 receptor	TEK	0.0041
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1353	DNA topoisomerase 1	TOP1	0.004
3552	DNA topoisomerase 1	topA	0.004
634	Squalene monooxygenase	SQLE	0.004
7196	Squalene monooxygenase	ERG1	0.004
6766	O-GlcNAcase BT_4395	BT_4395	0.004
4192	DNA topoisomerase 2-beta	TOP2B	0.004
2286	Isocitrate dehydrogenase [NADP]	icd	0.004
2302	Isocitrate dehydrogenase [NADP]	icd	0.004
2771	Isocitrate dehydrogenase [NADP]	icd	0.004
4491	DNA ligase, NAD-dependent	ligA	0.0039
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0039
2762	UDP-glucose 4-epimerase	GALE	0.0039
3461	UDP-glucose 4-epimerase	galE	0.0039
4217	Telomerase reverse transcriptase	TERT	0.0039
3639	Thymidine phosphorylase	deoA	0.0039
3936	Thymidine phosphorylase	TYMP	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
172	Potassium channel subfamily K member 1	KCNK1	0.0038
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0038
6048	Troponin C, skeletal muscle	TNNC2	0.0038
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0038
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
1525	Heparin-binding growth factor 2	FGF2	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
6044	Serum paraoxonase/lactonase 3	PON3	0.0037
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0036
164	Histamine H4 receptor	HRH4	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0036
1636	Trace amine-associated receptor 1	TAAR1	0.0036
4226	Uridine phosphorylase 2	UPP2	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
3904	Alanine aminotransferase 2	GPT2	0.0035
735	Alanine aminotransferase 1	GPT	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3856	Fibroblast growth factor receptor 3	FGFR3	0.0034
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0034
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0034
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
572	Integrin alpha-L	ITGAL	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
4225	Uridine phosphorylase 1	UPP1	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
268	Adenosine A2b receptor	ADORA2B	0.0031
2236	Casein kinase II subunit alpha	CSNK2A1	0.0031
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0031
1268	Neuropeptide S receptor	NPSR1	0.0031
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0031
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0031
2320	Thymidine kinase, cytosolic	TK1	0.003
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.003
1063	Signal transducer and activator of transcription 5B	STAT5B	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
413	Amidophosphoribosyltransferase	PPAT	0.003
2515	Amidophosphoribosyltransferase	purF	0.003
3714	Amidophosphoribosyltransferase	purF	0.003
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0029
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
2207	Rhodopsin	RHO	0.0028
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1374	Natriuretic peptides B	NPPB	0.0028
6073	Potassium channel subfamily K member 9	KCNK9	0.0028
6072	Potassium channel subfamily K member 3	KCNK3	0.0028
1827	Gap junction alpha-1 protein	GJA1	0.0028
1908	Vascular cell adhesion protein 1	VCAM1	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0027
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0026
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0026
291	Nitric-oxide synthase, endothelial	NOS3	0.0026
3830	Calreticulin	CALR	0.0026
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0026
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0026
5798	Mitogen-activated protein kinase 11	MAPK11	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
1864	RET proto-oncogene	RET	0.0026
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0025
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0025
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
798	Osteocalcin	BGLAP	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0024
6035	Nuclear receptor ROR-beta	RORB	0.0024
6036	Eosinophil peroxidase	EPX	0.0024
6824	Tyrosine-protein kinase Lyn	LYN	0.0024
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0023
2216	Fibroblast growth factor receptor 4	FGFR4	0.0023
369	Coagulation factor VII	F7	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
6131	Carbonic anhydrase 14	CA14	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.0021
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
3957	Adenosine deaminase	ADA	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.002
6122	Carbonic anhydrase 3	CA3	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4948	Cytochrome c-553	Not Available	0.0019
4923	Cytochrome c3	DvMF_2499	0.0019
4945	Cytochrome c3	Not Available	0.0019
4949	Cytochrome c3	DVU_3171	0.0019
4968	Cytochrome c3	cytc3	0.0019
4997	Cytochrome c3	SO_2727	0.0019
5219	Cytochrome c3	cyd	0.0019
4902	Nine-heme cytochrome c	Ddes_2038	0.0019
3189	High-molecular-weight cytochrome c	hmcA	0.0019
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
4210	Toll-like receptor 4	TLR4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
4954	Soluble cytochrome b558	Not Available	0.0018
4925	Cytochrome c-type protein SHP	shp	0.0018
4934	Cytochrome c-551	nirM	0.0018
5218	Cytochrome c-551	nirM	0.0018
4915	Cytochrome c-550	psbV	0.0018
4959	Cytochrome c-550	psbV	0.0018
5216	Cytochrome c-550	psbV	0.0018
4905	Cytochrome c2	Not Available	0.0018
4939	Cytochrome c2	cycA	0.0018
4964	Cytochrome c2	cycA	0.0018
4979	Cytochrome c2	cycA	0.0018
6673	Cytochrome c2	cycA	0.0018
4947	Bacterial hemoglobin	vhb	0.0018
4975	Cytochrome c-556	RPA3973	0.0018
4916	Cyanoglobin	glbN	0.0018
4943	Cytochrome c6	petJ	0.0018
4998	Hemoglobin-like protein yjbI	yjbI	0.0018
4984	Neuroglobin	NGB	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
3116	Bacterioferritin	bfr	0.0018
4906	Bacterioferritin	bfr	0.0018
4965	Bacterioferritin	bfr	0.0018
4936	Cytochrome c2 iso-2	Not Available	0.0018
4994	Hemoglobin-like protein HbO	glbO	0.0018
4907	Cytochrome c-L	moxG	0.0018
6865	Cytochrome c-L	moxG	0.0018
4909	CooA protein	cooA	0.0018
4942	Diheme cytochrome c napB	napB	0.0018
4910	Cytoglobin	CYGB	0.0018
4981	Iron-starvation protein PigA	pigA	0.0018
4935	Cytochrome c-554	cycA1	0.0018
5000	HemO	hemO	0.0018
4961	Hemophore HasA	hasA	0.0018
4971	Nonaheme cytochrome c	hmcA	0.0018
4904	Cytochrome c family protein	GSU1996	0.0018
4976	Apocytochrome f	petA	0.0018
6407	Apocytochrome f	petA	0.0018
4989	Cytochrome c551 peroxidase	ccp	0.0018
5222	Cytochrome c551 peroxidase	ccpA	0.0018
4999	Cytochrome P450 165B3	CYP165B3	0.0018
4764	Cytochrome P450 165C4	CYP165C4	0.0018
4960	Putative cytochrome P450-family protein	SCO7417	0.0018
4931	Cytochrome P450 167A1	CYP167A1	0.0018
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0018
4937	Cytochrome oxidase subunit II	rcoxA	0.0018
4903	Methyl-accepting chemotaxis protein	Tar4	0.0018
4993	Hydroxylamine oxidoreductase	hao1	0.0018
4972	P450cin	cinA	0.0018
4922	Cytochrome c, putative	SO_4144	0.0018
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0018
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0018
3093	Catalase HPII	katE	0.0018
4952	Catalase/peroxidase	katA	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
4386	Hemoglobin-like protein HbN	glbN	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
3221	Cytochrome c4	cc4	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6218	Pannexin-1	PANX1	0.0014
2021	Thrombomodulin	THBD	0.0013
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
4920	Peroxidase/catalase	katG	0.0013
2119	Cytochrome b5	CYB5A	0.0013
76	Nitric-oxide synthase, brain	NOS1	0.0013
4990	PpcA	ppcA	0.0013
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0013
3375	Acidic cytochrome c3	Not Available	0.0013
4988	Sulfite oxidase, mitochondrial	SUOX	0.0013
4385	Cytochrome c'	Not Available	0.0013
4967	Cytochrome c'	cycA	0.0013
5038	Cytochrome c'	Not Available	0.0013
5223	Cytochrome c'	cycP	0.0013
2915	Sensor protein fixL	fixL	0.0013
4944	Sensor protein fixL	fixL	0.0013
3570	Cytochrome P450 152A1	cypC	0.0013
4037	Hypothetical protein	GPX1	0.0013
4297	Hypothetical protein	SP_1951	0.0013
4521	Hypothetical protein	BC_2969	0.0013
4540	Hypothetical protein	TM_1070	0.0013
4555	Hypothetical protein	MT1739	0.0013
4569	Hypothetical protein	mshD	0.0013
4578	Hypothetical protein	PA3270	0.0013
4747	Hypothetical protein	PA3967	0.0013
5177	Hypothetical protein	TM_0096	0.0013
5194	Hypothetical protein	PA1204	0.0013
5240	Hypothetical protein	Rv2991	0.0013
5370	Hypothetical protein	TM_1158	0.0013
5710	Hypothetical protein	Tb927.5.1360	0.0013
4992	Cytochrome c peroxidase	Not Available	0.0013
4813	Heme oxygenase	hmuO	0.0013
5769	Heme oxygenase	Not Available	0.0013
4289	Cytochrome P450	TT_P0059	0.0013
6262	Cytochrome P450	staP	0.0013
3007	Carbonic anhydrase 12	CA12	0.0013
4205	Carbonic anhydrase 9	CA9	0.0013
1650	Heme carrier protein 1	SLC46A1	0.0013
1507	Cytochrome c	CYCS	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1295	Fatty acid synthase	FASN	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3670	Soluble cytochrome b562 precursor	cybC	0.0011
3411	Cytochrome P450 121	cyp121	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
3291	Cytochrome c-552	cycA	0.0011
4927	Cytochrome c-552	nrfA	0.0011
4938	Cytochrome c-552	cycA	0.0011
4953	Cytochrome c-552	nrfA	0.0011
5217	Cytochrome c-552	cycM	0.0011
2617	Nitric oxide synthase oxygenase	nos	0.0011
2701	Nitric oxide synthase oxygenase	nos	0.0011
3102	Flavohemoprotein	hmp	0.0011
4969	Flavohemoprotein	hmp	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
760	Fibroblast growth factor 1	FGF1	0.001
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
4608	Putative cytochrome P450	SCO1207	0.0009
4963	Putative cytochrome P450	SCO2884	0.0009
6254	Putative cytochrome P450	SCO6998	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
358	Cystathionine beta-synthase	CBS	0.0009
6677	Myelin P2 protein	PMP2	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
693	Hemoglobin subunit beta	HBB	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
1867	Major prion protein	PRNP	0.0008
6268	Hydroxyacid oxidase 1	HAO1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
2240	Cell division protein kinase 2	CDK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00755 - Tretinoin

Targets

Enzymes

Transporters

Predictions