DT-Web

DB06210 - Eltrombopag


Identification
Name Eltrombopag
Accession Number DB06210
Type small molecule
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 442.4666
Groups approved
Monoisotopic Weight 442.164105212
Pharmacology
Indication Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Mechanism of action Eltrombopag is an orally bioavailable, small-molecule TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor. Eltrombopag is a stimulator of STAT and JAK phosphorylation. Unlike recombinant TPO or romiplostim, Eltrombopag does not activate the AKT pathway in any way. It should be noted that when given to patients with aplastic anemia, other lineages besides platelet count were increased, suggesting that either eltrombopag enhanced the effect of TPO in vivo; or there is a yet uncovered mechanism of action at work.
Absorption Peak absorption of Eltrombopag occurs around 2-6 hours following oral administration, and the total oral absorption of drug-related material following a 75 mg dose was estimated to be at least 52%.
Protein binding Eltrombopag is highly protein bound (>99%).
Biotransformation Eltrombopag is predominantly through pathways including cleavage, oxidation, and conjugation with glucuronic acid, glutathione, or cysteine. In vitro studies suggest that CYP1A2 and CYP2C8 are responsible for the oxidative metabolism of eltrombopag. UGT1A1 and UGT1A3 are responsible for the glucuronidation of eltrombopag.
Route of elimination Eltrombopag is eliminated primarily via the feces (59%), along with 31% being renally excreted.
Toxicity Eltrombopag may cause hepatotoxicity, especially if administered in combination with interferon and ribavirin in patients with chronic hepatitis C (may increase the risk of hepatic decompensation).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetaminophen Eltrombopag increases acetaminophen levels via decreasing metabolism. UDP-glucuronosyltransferase inhibition with unclear significance.
Acetylsalicylic acid Decreases metabolism, will increase effect/level of eltrombopag.
Aluminum hydroxide Decreases levels of eltrombopag by GI absorption inhibition.
Amiodarone Affects hepatic enzyme CYP2C9/10 metabolism, increases effect/level of eltrombopag.
Amobarbital Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Atazanavir Decreases metabolism, will increase effect/level of eltrombopag. UDP-glucuronosyltransferase inhibition.
Atorvastatin Eltrombopag increases levels of Atorvastatin via metabolism decrease.
Bromfenac Eltrombopag increases levels of Bromfenac via metabolism decrease.
Butabarbital Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Butalbital Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Calcium Acetate Calcium Salts such as calcium acetate may decrease the serum concentration of Eltrombopag. Separate administration of eltrombopag and any polyvalent cation (e.g., calcium-containing products) by at least 4 hours.
Calcium carbonate Decreases levels of eltrombopag by GI absorption inhibition.
Calcium Chloride Calcium salts such as calcium chloride may decrease the serum concentration of eltrombopag. Separate administration of eltrombopag and any polyvalent cation (e.g., calcium-containing products) by at least 4 hours.
Carbamazepine Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Celecoxib Eltrombopag increases levels of Celecoxib via metabolism decrease.
Cimetidine Affects hepatic CYP1A2 metabolism, will decrease effect/level of eltrombopag. Affects hepatic CYP2C9/10 metabolism, will decrease effect/level of eltrombopag.
Ciprofloxacin Affects hepatic CYP1A2 metabolism, will increase effect/level of eltrombopag.
Citric Acid Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Diclofenac Eltrombopag increases levels of Diclofenac via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Diflunisal Eltrombopag increases levels of Diflunisal via metabolism decrease.
Diltiazem Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Efavirenz Affects hepatic enzyme CYP2C9/10 metabolism and may increase the level of eltrombopag.
Enoxacin Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Erythromycin Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Ethinyl Estradiol Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Etodolac Increases levels of Etodolac via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Fenoprofen Increases levels of Fenoprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Fentanyl Increases levels of Fentanyl via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Flurbiprofen Increases levels of Flurbiprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Fluvastatin Increases levels of Fluvastatin via metabolism decrease. OATP transporter protein inhibition.
Fluvoxamine Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Fluvoxamine Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Grepafloxacin Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Hydrocodone Increases levels of Hydrocodone via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Hydromorphone Increases levels of Hydromorphone via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Ibuprofen Increases levels of Ibuprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Indomethacin Increases levels of Indomethacin via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Iron Dextran Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Iron sucrose Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Isoniazid Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Ketoprofen Increases levels of Ketoprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Ketorolac Increases levels of Ketorolac via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Leflunomide Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Levorphanol Increases levels of Levorphanol via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Magnesium Sulfate Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Meclofenamic acid Increases levels of Meclofenamic acid via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Mefenamic acid Increases levels of Mefenamic acid via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Meloxicam Increases levels of Meloxicam via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Meperidine Increases levels of Meperidine via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Methadone Increases levels of Methadone via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Methotrexate Increases levels of Methotrexate via metabolism decrease. OATP transporter protein inhibition.
Mexiletine Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Miconazole Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Morphine Eltrombopag increases Morphine levels via decreasing metabolism. UDP-glucuronosyltransferase inhibition with unclear significance.
Selenium Sulfide Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Sodium bicarbonate Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Tretinoin The moderate CYP2C8 inhibitor, Eltrombopag, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Eltrombopag is initiated, discontinued or dose changed.
Valproic Acid Affects hepatic CYP2C9/10 metabolism, will increase effect/level of eltrombopag.
Valsartan Eltrombopag may increase the therapeutic and/or toxic effects of Valsartan. Increased Valsartan serum concentrations may be caused by inhibition of hepatic uptake and decreased metabolism. Consider dose modification, alternate therapy or monitor for changes in the therapeutic and toxic effects of Valsartan if Eltrombopag is initiated, discontinued or dose changed.
Zileuton Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Food Interactions Not Available

Targets


Thrombopoietin receptor
Name Thrombopoietin receptor
Gene Name MPL
Pharmacological action unknown
Actions agonist
References
  • Kuter DJ: Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med. 2009;60:193-206. - Pubmed
DTHybrid score 1.2108

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • GlaxoSmithKline. Promacta (eltrombopag) tablets prescribing information. Research Triangle Park, NC; 2009 Oct. -
DTHybrid score 0.309
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • GlaxoSmithKline. Promacta (eltrombopag) tablets prescribing information. Research Triangle Park, NC; 2009 Oct. -
DTHybrid score 0.3379
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • GlaxoSmithKline. Promacta (eltrombopag) tablets prescribing information. Research Triangle Park, NC; 2009 Oct. -
DTHybrid score 0.302
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • GlaxoSmithKline. Promacta (eltrombopag) tablets prescribing information. Research Triangle Park, NC; 2009 Oct. -
DTHybrid score 0.282

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • GlaxoSmithKline. Promacta (eltrombopag) tablets prescribing information. Research Triangle Park, NC; 2009 Oct. -
  • Kuter DJ: The biology of thrombopoietin and thrombopoietin receptor agonists. Int J Hematol. 2013 Jul;98(1):10-23. doi: 10.1007/s12185-013-1382-0. Epub 2013 Jul 3. - Pubmed
DTHybrid score 0.296

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2129
4757 Cytochrome P450 2C9 CYP2C9 0.2074
1588 Multidrug resistance protein 1 ABCB1 0.1668
6016 Cytochrome P450 2C19 CYP2C19 0.145
4119 Cytochrome P450 2D6 CYP2D6 0.1334
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.123
4118 Cytochrome P450 3A5 CYP3A5 0.1068
6030 Cytochrome P450 2B6 CYP2B6 0.0949
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0898
20 Prostaglandin G/H synthase 1 PTGS1 0.0782
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0778
587 Serum albumin ALB 0.0773
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0762
6024 Cytochrome P450 1A1 CYP1A1 0.0757
6107 Cytochrome P450 3A7 CYP3A7 0.0713
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0713
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0665
6013 Cytochrome P450 2E1 CYP2E1 0.0653
1729 Solute carrier family 22 member 6 SLC22A6 0.0588
5718 Cytochrome P450 2A6 CYP2A6 0.0525
290 Prostaglandin G/H synthase 2 PTGS2 0.0463
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0436
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0432
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0432
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0428
70 Type-1 angiotensin II receptor AGTR1 0.0407
862 Multidrug resistance-associated protein 1 ABCC1 0.0385
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0375
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0374
2164 Multidrug resistance-associated protein 4 ABCC4 0.0374
6142 Solute carrier family 22 member 8 SLC22A8 0.0329
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0312
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0301
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.028
6106 Cytochrome P450 2C18 CYP2C18 0.0279
6026 Alcohol dehydrogenase 6 ADH6 0.0266
36 Insulin receptor INSR 0.0258
492 Histamine H1 receptor HRH1 0.024
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0239
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0237
1898 Cytochrome P450 1B1 CYP1B1 0.0235
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0234
6145 Solute carrier family 22 member 1 SLC22A1 0.0233
776 Bile salt export pump ABCB11 0.0224
26 Vascular endothelial growth factor receptor 3 FLT4 0.0222
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0215
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0214
32 Vascular endothelial growth factor receptor 1 FLT1 0.0212
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0207
502 5-hydroxytryptamine 2A receptor HTR2A 0.0203
3811 Cytochrome P450 19A1 CYP19A1 0.0199
1024 Solute carrier family 22 member 11 SLC22A11 0.0192
6102 Arylamine N-acetyltransferase 2 NAT2 0.0189
6141 Sodium/bile acid cotransporter SLC10A1 0.0188
696 Kappa-type opioid receptor OPRK1 0.0184
6143 Solute carrier family 22 member 7 SLC22A7 0.0183
467 Delta-type opioid receptor OPRD1 0.018
117 Sterol O-acyltransferase 1 SOAT1 0.0177
407 Vascular endothelial growth factor receptor 2 KDR 0.0176
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0173
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0173
504 Mast/stem cell growth factor receptor KIT 0.0173
847 Mu-type opioid receptor OPRM1 0.0173
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0171
118 Organic cation/carnitine transporter 2 SLC22A5 0.0169
590 5-hydroxytryptamine 2C receptor HTR2C 0.0166
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0163
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.016
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0159
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0158
3941 Amine oxidase [flavin-containing] A MAOA 0.0154
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0154
146 Androgen receptor AR 0.0152
1760 Aminopeptidase N ANPEP 0.0151
6843 Aminopeptidase N pepN 0.0151
3810 Catechol O-methyltransferase COMT 0.0151
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0144
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0143
136 Estrogen receptor ESR1 0.0142
6144 Solute carrier family 22 member 2 SLC22A2 0.0139
766 Beta-2 adrenergic receptor ADRB2 0.0138
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0138
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0137
4604 Liver carboxylesterase 1 CES1 0.0134
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0133
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0133
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0132
831 D(2) dopamine receptor DRD2 0.0131
6044 Serum paraoxonase/lactonase 3 PON3 0.013
824 Sodium-dependent serotonin transporter SLC6A4 0.0128
318 Alpha-2A adrenergic receptor ADRA2A 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
4122 Histone deacetylase 2 HDAC2 0.0127
1630 Integrin beta-2 ITGB2 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
885 5-hydroxytryptamine 1B receptor HTR1B 0.0125
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0124
833 Organic cation/carnitine transporter 1 SLC22A4 0.0124
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0123
6136 Multidrug resistance-associated protein 5 ABCC5 0.0122
228 Beta platelet-derived growth factor receptor PDGFRB 0.0121
817 DNA topoisomerase 2-alpha TOP2A 0.0119
3587 Gastrotropin FABP6 0.0118
6220 Aryl hydrocarbon receptor AHR 0.0118
6148 Multidrug resistance-associated protein 7 ABCC10 0.0117
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0114
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0114
731 HIV-1 protease HIV-1 protease 0.0113
725 5-hydroxytryptamine 1D receptor HTR1D 0.0113
758 Thyroid hormone receptor alpha THRA 0.0113
468 Cytochrome P450 4A11 CYP4A11 0.0111
1629 Transcription factor AP-1 JUN 0.011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0109
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0109
6147 Solute carrier family 22 member 3 SLC22A3 0.0106
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0105
23 D(1A) dopamine receptor DRD1 0.0105
319 Opioid receptor, sigma 1 OPRS1 0.0105
556 Alpha-1A adrenergic receptor ADRA1A 0.0103
6085 Fatty acid-binding protein, intestinal FABP2 0.0102
811 Translocator protein TSPO 0.0101
346 Thyroid hormone receptor beta-1 THRB 0.01
275 Arachidonate 5-lipoxygenase ALOX5 0.01
540 Sodium-dependent noradrenaline transporter SLC6A2 0.01
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0096
572 Integrin alpha-L ITGAL 0.0095
273 Apoptosis regulator Bcl-2 BCL2 0.0094
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0093
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0092
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0092
267 Plasminogen activator inhibitor 1 SERPINE1 0.0091
320 5-hydroxytryptamine 1A receptor HTR1A 0.009
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0089
3856 Fibroblast growth factor receptor 3 FGFR3 0.0087
373 Transthyretin TTR 0.0087
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0086
3809 Estrogen-related receptor gamma ESRRG 0.0084
738 Monocarboxylate transporter 1 SLC16A1 0.0084
3939 Amine oxidase [flavin-containing] B MAOB 0.0084
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0083
6221 Steroid hormone receptor ERR1 ESRRA 0.0083
6031 Cytochrome P450 3A43 CYP3A43 0.0082
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.008
2021 Thrombomodulin THBD 0.008
594 Thyroxine-binding globulin SERPINA7 0.008
16 Adenosine A1 receptor ADORA1 0.0079
341 5-hydroxytryptamine 3 receptor HTR3A 0.0078
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0077
844 Epidermal growth factor receptor EGFR 0.0077
465 Calmodulin CALM1 0.0075
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0075
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0075
632 Alpha-1B adrenergic receptor ADRA1B 0.0074
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0073
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0072
3923 Cholinesterase BCHE 0.0071
511 5-hydroxytryptamine 1F receptor HTR1F 0.007
871 Glucocorticoid receptor NR3C1 0.007
193 Beta-1 adrenergic receptor ADRB1 0.0069
459 Retinoic acid receptor RXR-alpha RXRA 0.0069
6167 Organic solute transporter subunit beta OSTB 0.0069
6166 Organic solute transporter subunit alpha OSTA 0.0069
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0068
952 Dipeptidyl peptidase 4 DPP4 0.0068
869 Estrogen receptor beta ESR2 0.0067
1178 Adenosine A2a receptor ADORA2A 0.0066
1757 Myeloperoxidase MPO 0.0066
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0066
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0065
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0065
713 Sodium-dependent dopamine transporter SLC6A3 0.0065
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0065
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0064
629 Alpha-2B adrenergic receptor ADRA2B 0.0064
638 D(3) dopamine receptor DRD3 0.0064
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0063
6137 Multidrug resistance-associated protein 6 ABCC6 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0062
29 Tubulin beta-1 chain TUBB1 0.0062
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0061
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0059
777 Tumor necrosis factor TNF 0.0058
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0058
789 Alpha-1D adrenergic receptor ADRA1D 0.0057
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0057
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0057
6182 Cytochrome P450 2J2 CYP2J2 0.0057
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0056
1792 Tissue-type plasminogen activator PLAT 0.0055
284 DNA-directed RNA polymerase beta chain rpoB 0.0054
5773 DNA-directed RNA polymerase beta chain rpoB 0.0054
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0054
760 Fibroblast growth factor 1 FGF1 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0053
378 Alpha-2C adrenergic receptor ADRA2C 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
1050 Bile salt sulfotransferase SULT2A1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
365 Dihydrofolate reductase DHFR 0.005
2381 Dihydrofolate reductase DFR1 0.005
2833 Dihydrofolate reductase Not Available 0.005
2931 Dihydrofolate reductase folA 0.005
3544 Dihydrofolate reductase folA 0.005
3682 Dihydrofolate reductase folA 0.005
6642 Dihydrofolate reductase folA 0.005
6756 Dihydrofolate reductase dfrA 0.005
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.005
756 Sex hormone-binding globulin SHBG 0.005
199 Monocarboxylate transporter 8 SLC16A2 0.005
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.005
3947 Xanthine dehydrogenase/oxidase XDH 0.005
563 Thyroid peroxidase TPO 0.005
2539 Tubulin alpha-1 chain TUBA4A 0.0049
1192 Sulfotransferase 1A1 SULT1A1 0.0049
33 Cystine/glutamate transporter SLC7A11 0.0048
380 Cytochrome P450 17A1 CYP17A1 0.0048
1039 Histone deacetylase 9 HDAC9 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
94 5-hydroxytryptamine 4 receptor HTR4 0.0047
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
1353 DNA topoisomerase 1 TOP1 0.0045
3552 DNA topoisomerase 1 topA 0.0045
260 Cytochrome P450 51 ERG11 0.0044
761 Cytochrome P450 51 ERG11 0.0044
3163 Cytochrome P450 51 cyp51 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0044
4692 A/G-specific adenine glycosylase mutY 0.0043
6020 Aldehyde oxidase AOX1 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
432 D(4) dopamine receptor DRD4 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
823 Fibroblast growth factor receptor 2 FGFR2 0.0042
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
122 P2Y purinoceptor 12 P2RY12 0.0042
4192 DNA topoisomerase 2-beta TOP2B 0.0042
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0042
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0041
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0041
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
908 Glutathione S-transferase theta-1 GSTT1 0.0039
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0039
1618 High affinity nerve growth factor receptor NTRK1 0.0039
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0039
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0039
1648 Elastin ELN 0.0039
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0038
1275 Estrogen sulfotransferase SULT1E1 0.0038
165 FL cytokine receptor FLT3 0.0038
436 5-hydroxytryptamine 2B receptor HTR2B 0.0037
904 Glutathione S-transferase P GSTP1 0.0037
2981 Phospholipase A2, membrane associated PLA2G2A 0.0037
1010 Cytochrome P450 51A1 CYP51A1 0.0036
88 Retinoic acid receptor RXR-beta RXRB 0.0035
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0035
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0035
5798 Mitogen-activated protein kinase 11 MAPK11 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
1541 Metalloproteinase mmp20 0.0035
162 Retinoic acid receptor gamma-1 RARG 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0033
5787 Angiopoietin-1 receptor TEK 0.0033
229 Retinoic acid receptor beta RARB 0.0033
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0033
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0033
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
427 Substance-P receptor TACR1 0.0031
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
6151 Monocarboxylate transporter 10 SLC16A10 0.0031
6043 Putative G-protein coupled receptor 44 GPR44 0.003
818 50S ribosomal protein L10 rplJ 0.003
891 Dihydropteroate synthase folP 0.003
5359 Dihydropteroate synthase folP 0.003
7175 Dihydropteroate synthase sulI 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.003
173 Toll-like receptor 7 TLR7 0.003
921 Glutamate receptor 2 GRIA2 0.003
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
737 Mineralocorticoid receptor NR3C2 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
3957 Adenosine deaminase ADA 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
518 Peroxidase/catalase T katG 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
751 Potassium channel subfamily K member 6 KCNK6 0.0027
4120 NADPH--cytochrome P450 reductase POR 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0026
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
4116 Dihydropteroate synthetase Not Available 0.0025
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0025
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
634 Squalene monooxygenase SQLE 0.0024
7196 Squalene monooxygenase ERG1 0.0024
6070 Nischarin NISCH 0.0024
614 Progesterone receptor PGR 0.0023
6149 Solute carrier family 22 member 10 SLC22A10 0.0023
124 Histamine H2 receptor HRH2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0023
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0022
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
3086 Plasmepsin-2 Not Available 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6146 High affinity copper uptake protein 1 SLC31A1 0.0021
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0021
6042 Prostaglandin reductase 2 PTGR2 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
208 DNA-directed RNA polymerase beta' chain rpoC 0.0021
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0021
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.002
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
1256 5-hydroxytryptamine 6 receptor HTR6 0.002
1820 Beta-nerve growth factor NGF 0.002
4203 Histamine N-methyltransferase HNMT 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
239 Coagulation factor X F10 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0018
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0018
6103 Arylamine N-acetyltransferase 1 NAT1 0.0018
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
976 Platelet glycoprotein IX GP9 0.0017
4103 Proteasome subunit beta type 2 PSMB2 0.0017
4102 Proteasome subunit beta type 5 PSMB5 0.0017
4101 Proteasome subunit beta type 1 PSMB1 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
1656 CYP2B protein CYP2B 0.0017
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0017
814 Ryanodine receptor 1 RYR1 0.0016
1830 5'-nucleotidase NT5E 0.0016
469 Annexin A1 ANXA1 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0016
1313 Lactoylglutathione lyase GLO1 0.0016
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0016
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0016
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0016
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0016
1243 Cathepsin D CTSD 0.0016
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0016
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0016
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0016
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0016
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0016
474 Acetylcholinesterase ACHE 0.0016
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
780 Retinoic acid receptor RXR-gamma RXRG 0.0015
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0015
6174 50S ribosomal protein L32 rpmF 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
6432 Transporter snf 0.0015
268 Adenosine A2b receptor ADORA2B 0.0014
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0014
6138 Multidrug resistance protein 3 ABCB4 0.0014
5818 Folate receptor alpha FOLR1 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
2808 Chloramphenicol acetyltransferase 3 cat3 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
517 Alcohol dehydrogenase 1C ADH1C 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
581 Cytochrome P450 2R1 CYP2R1 0.0011
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0011
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
1650 Heme carrier protein 1 SLC46A1 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
161 Tubulin beta chain TUBB 0.0011
312 Tubulin beta chain TUB2 0.0011
1992 Vitamin D-binding protein GC 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
1483 Membrane copper amine oxidase AOC3 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
6459 Glycodelin PAEP 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
4217 Telomerase reverse transcriptase TERT 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
6677 Myelin P2 protein PMP2 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
6500 Phospholipase A2 PLA2G1B 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6048 Troponin C, skeletal muscle TNNC2 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
295 Carbonic anhydrase 1 CA1 0.0008
3830 Calreticulin CALR 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
719 Retinoic acid receptor responder protein 1 RARRES1 0.0008
770 Retinoic acid-induced protein 3 GPRC5A 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
856 Vitamin D3 receptor VDR 0.0008
6036 Eosinophil peroxidase EPX 0.0008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
2207 Rhodopsin RHO 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
2320 Thymidine kinase, cytosolic TK1 0.0007
569 Retinal dehydrogenase 2 ALDH1A2 0.0007
822 Aldose reductase AKR1B1 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
1852 Microtubule-associated protein 2 MAP2 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
164 Histamine H4 receptor HRH4 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
6218 Pannexin-1 PANX1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
183 Vascular endothelial growth factor A VEGFA 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
798 Osteocalcin BGLAP 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0003
54 Prothrombin F2 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4943 Cytochrome c6 petJ 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4961 Hemophore HasA hasA 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
5000 HemO hemO 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
4984 Neuroglobin NGB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4935 Cytochrome c-554 cycA1 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4910 Cytoglobin CYGB 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
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