DT-Web

DB00744 - Zileuton


Identification
Name Zileuton
Accession Number DB00744 (APRD00265)
Type small molecule
Description Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 236.29
Groups approved
Monoisotopic Weight 236.061948328
Pharmacology
Indication For the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.
Mechanism of action Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. Due to the role of leukotrienes in the pathogenesis of asthma, modulation of leukotriene formation by interruption of 5-lipoxygenase activity may reduce airway symptoms, decrease bronchial smooth muscle tone, and improve asthma control.
Absorption Rapidly and almost completely absorbed. The absolute bioavailability is unknown.
Protein binding 93% bound to plasma proteins, primarily to albumin.
Biotransformation Hepatic. Zileuton and its N-dehydroxylated metabolite are oxidatively metabolized by the cytochrome P450 isoenzymes 1A2, 2C9 and 3A4.
Route of elimination Elimination of zileuton is predominantly via metabolism with a mean terminal half-life of 2.5 hours. The urinary excretion of the inactive N-dehydroxylated metabolite and unchanged zileuton each accounted for less than 0.5% of the dose.
Toxicity The oral minimum lethal doses in mice and rats were 500-4000 and 300-1000 mg/kg in various preparations, respectively (providing greater than 3 and 9 times the systemic exposure [AUC] achieved at the maximum recommended human daily oral dose, respectively).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline Zileuton increases the effect and toxicity of theophylline
Bendamustine CYP1A2 metabolism may result in increased levels of active metabolites, decreases levels of bendamustine.
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Eltrombopag Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Ergotamine Possible ergotism and severe ischemia with this combination
Oxtriphylline Zileuton increases the effect and toxicity of theophylline
Pimozide Increased risk of cardiotoxicity and arrhythmias
Ramelteon Zileuton increases levels/toxicity of ramelteon
Theophylline Zileuton may increase the therapeutic and adverse effects of theophylline by increasing its serum concentration. Monitor for changes in the therapeutic and adverse effects of theophylline if zileuton is initiated, discontinued or dose changed. Dose alterations should be considered.
Food Interactions Not Available

Targets


Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action yes
Actions inhibitor
References
  • Wenzel SE: Leukotriene receptor antagonists and related compounds. Can Respir J. 1999 Mar-Apr;6(2):189-93. - Pubmed
  • Hardy DB, Pereria LE, Yang K: Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biol Reprod. 1999 Jul;61(1):40-5. - Pubmed
  • Yamashita M, Kushihara M, Hirasawa N, Takasaki W, Takahagi H, Takayanagi M, Ohuchi K: Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. Br J Pharmacol. 2000 Jan;129(2):367-73. - Pubmed
  • Qian C, Hwang SB, Libertine-Garahan L, Eckman JB, Cai X, Scannell RT, Yeh CG: Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. Pharmacol Res. 2001 Sep;44(3):213-20. - Pubmed
  • Coffey MJ, Phare SM, Peters-Golden M: Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther. 2001 Oct;299(1):198-203. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Zouboulis CC: Zileuton, a new efficient and safe systemic anti-acne drug. Dermatoendocrinol. 2009 May;1(3):188-92. - Pubmed
  • Zouboulis CC, Seltmann H, Alestas T: Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. Exp Dermatol. 2010 Feb;19(2):148-50. Epub 2009 Jul 23. - Pubmed
  • Berger W, De Chandt MT, Cairns CB: Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease. Int J Clin Pract. 2007 Apr;61(4):663-76. - Pubmed
  • Guidot DM, Repine MJ, Westcott JY, Repine JE: Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8156-9. - Pubmed
  • Wenzel SE, Kamada AK: Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma. Ann Pharmacother. 1996 Jul-Aug;30(7-8):858-64. - Pubmed
DTHybrid score 0.2895

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3934
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Machinist JM, Mayer MD, Shet MS, Ferrero JL, Rodrigues AD: Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug Metab Dispos. 1995 Oct;23(10):1163-74. - Pubmed
DTHybrid score 0.3369
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Machinist JM, Mayer MD, Shet MS, Ferrero JL, Rodrigues AD: Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug Metab Dispos. 1995 Oct;23(10):1163-74. - Pubmed
DTHybrid score 0.4424
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5551
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.255

Predictions


Id Partner name Gene Name Score
290 Prostaglandin G/H synthase 2 PTGS2 0.2486
6016 Cytochrome P450 2C19 CYP2C19 0.2048
4119 Cytochrome P450 2D6 CYP2D6 0.1827
4924 Cytochrome P450 2C8 CYP2C8 0.1735
1588 Multidrug resistance protein 1 ABCB1 0.1382
4118 Cytochrome P450 3A5 CYP3A5 0.1245
6030 Cytochrome P450 2B6 CYP2B6 0.1035
6013 Cytochrome P450 2E1 CYP2E1 0.0973
587 Serum albumin ALB 0.0963
6107 Cytochrome P450 3A7 CYP3A7 0.0856
6024 Cytochrome P450 1A1 CYP1A1 0.0843
1729 Solute carrier family 22 member 6 SLC22A6 0.0784
5718 Cytochrome P450 2A6 CYP2A6 0.0775
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0647
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0634
238 Peroxisome proliferator-activated receptor gamma PPARG 0.058
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0575
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0556
6182 Cytochrome P450 2J2 CYP2J2 0.054
1757 Myeloperoxidase MPO 0.0527
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0483
6106 Cytochrome P450 2C18 CYP2C18 0.0417
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0405
3923 Cholinesterase BCHE 0.0375
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0353
703 NADPH azoreductase azr 0.0352
492 Histamine H1 receptor HRH1 0.0341
2164 Multidrug resistance-associated protein 4 ABCC4 0.0337
6142 Solute carrier family 22 member 8 SLC22A8 0.0336
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0328
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0326
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0317
862 Multidrug resistance-associated protein 1 ABCC1 0.0311
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0311
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
3811 Cytochrome P450 19A1 CYP19A1 0.0301
3810 Catechol O-methyltransferase COMT 0.0281
824 Sodium-dependent serotonin transporter SLC6A4 0.0279
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0276
502 5-hydroxytryptamine 2A receptor HTR2A 0.0271
36 Insulin receptor INSR 0.0258
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0257
1024 Solute carrier family 22 member 11 SLC22A11 0.0256
831 D(2) dopamine receptor DRD2 0.0249
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0248
847 Mu-type opioid receptor OPRM1 0.0248
6143 Solute carrier family 22 member 7 SLC22A7 0.0248
6102 Arylamine N-acetyltransferase 2 NAT2 0.0239
1898 Cytochrome P450 1B1 CYP1B1 0.0239
467 Delta-type opioid receptor OPRD1 0.0235
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0235
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0227
318 Alpha-2A adrenergic receptor ADRA2A 0.0226
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0226
556 Alpha-1A adrenergic receptor ADRA1A 0.0225
136 Estrogen receptor ESR1 0.0224
696 Kappa-type opioid receptor OPRK1 0.0224
6145 Solute carrier family 22 member 1 SLC22A1 0.0215
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0214
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.021
341 5-hydroxytryptamine 3 receptor HTR3A 0.0208
1507 Cytochrome c CYCS 0.02
4604 Liver carboxylesterase 1 CES1 0.0198
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0194
23 D(1A) dopamine receptor DRD1 0.0194
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0193
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0189
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0188
871 Glucocorticoid receptor NR3C1 0.0186
891 Dihydropteroate synthase folP 0.0183
5359 Dihydropteroate synthase folP 0.0183
7175 Dihydropteroate synthase sulI 0.0183
118 Organic cation/carnitine transporter 2 SLC22A5 0.0177
6144 Solute carrier family 22 member 2 SLC22A2 0.0177
320 5-hydroxytryptamine 1A receptor HTR1A 0.0176
590 5-hydroxytryptamine 2C receptor HTR2C 0.0173
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.017
817 DNA topoisomerase 2-alpha TOP2A 0.0167
738 Monocarboxylate transporter 1 SLC16A1 0.0166
3941 Amine oxidase [flavin-containing] A MAOA 0.0166
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0163
731 HIV-1 protease HIV-1 protease 0.0161
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0159
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0158
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0157
885 5-hydroxytryptamine 1B receptor HTR1B 0.0156
776 Bile salt export pump ABCB11 0.0152
70 Type-1 angiotensin II receptor AGTR1 0.0152
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0152
632 Alpha-1B adrenergic receptor ADRA1B 0.015
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0149
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0148
260 Cytochrome P450 51 ERG11 0.0146
761 Cytochrome P450 51 ERG11 0.0146
3163 Cytochrome P450 51 cyp51 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0146
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0144
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
4132 Chloride channel protein ClC-Ka CLCNKA 0.0143
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0142
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0142
713 Sodium-dependent dopamine transporter SLC6A3 0.0142
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.014
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0137
725 5-hydroxytryptamine 1D receptor HTR1D 0.0136
373 Transthyretin TTR 0.0135
766 Beta-2 adrenergic receptor ADRB2 0.0133
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0132
183 Vascular endothelial growth factor A VEGFA 0.0131
33 Cystine/glutamate transporter SLC7A11 0.0128
122 P2Y purinoceptor 12 P2RY12 0.0128
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0128
638 D(3) dopamine receptor DRD3 0.0128
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0128
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0124
6103 Arylamine N-acetyltransferase 1 NAT1 0.0124
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0123
789 Alpha-1D adrenergic receptor ADRA1D 0.0123
3939 Amine oxidase [flavin-containing] B MAOB 0.0123
629 Alpha-2B adrenergic receptor ADRA2B 0.0122
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.012
193 Beta-1 adrenergic receptor ADRB1 0.0117
1650 Heme carrier protein 1 SLC46A1 0.0116
811 Translocator protein TSPO 0.0114
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0113
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0112
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0111
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0109
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0108
504 Mast/stem cell growth factor receptor KIT 0.0108
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0108
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0108
6147 Solute carrier family 22 member 3 SLC22A3 0.0108
6031 Cytochrome P450 3A43 CYP3A43 0.0108
459 Retinoic acid receptor RXR-alpha RXRA 0.0106
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0106
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0105
777 Tumor necrosis factor TNF 0.0104
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0104
140 30S ribosomal protein S9 rpsI 0.0103
6719 30S ribosomal protein S9 rpsI 0.0103
6725 30S ribosomal protein S9 rpsI 0.0103
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0102
407 Vascular endothelial growth factor receptor 2 KDR 0.0101
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0101
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
1654 Interleukin-1 beta IL1B 0.01
6043 Putative G-protein coupled receptor 44 GPR44 0.01
228 Beta platelet-derived growth factor receptor PDGFRB 0.0099
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0098
378 Alpha-2C adrenergic receptor ADRA2C 0.0098
26 Vascular endothelial growth factor receptor 3 FLT4 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0097
54 Prothrombin F2 0.0095
465 Calmodulin CALM1 0.0095
6085 Fatty acid-binding protein, intestinal FABP2 0.0094
146 Androgen receptor AR 0.0094
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0094
32 Vascular endothelial growth factor receptor 1 FLT1 0.0093
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0092
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0091
571 Melatonin receptor type 1A MTNR1A 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
6500 Phospholipase A2 PLA2G1B 0.009
6014 Cytochrome P450 2A13 CYP2A13 0.0089
489 Monocarboxylate transporter 2 SLC16A7 0.0089
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0089
818 50S ribosomal protein L10 rplJ 0.0089
16 Adenosine A1 receptor ADORA1 0.0088
6220 Aryl hydrocarbon receptor AHR 0.0087
3312 Fatty acid-binding protein, brain FABP7 0.0086
1275 Estrogen sulfotransferase SULT1E1 0.0085
22 30S ribosomal protein S4 rpsD 0.0084
6714 30S ribosomal protein S4 rpsD 0.0084
2981 Phospholipase A2, membrane associated PLA2G2A 0.0083
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0083
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0083
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0083
833 Organic cation/carnitine transporter 1 SLC22A4 0.0083
494 Caspase-1 CASP1 0.0083
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0083
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0082
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
432 D(4) dopamine receptor DRD4 0.0082
427 Substance-P receptor TACR1 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.008
232 Corticosteroid-binding globulin SERPINA6 0.008
322 Vasopressin V2 receptor AVPR2 0.008
273 Apoptosis regulator Bcl-2 BCL2 0.008
614 Progesterone receptor PGR 0.0079
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0079
1648 Elastin ELN 0.0076
904 Glutathione S-transferase P GSTP1 0.0076
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0076
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0076
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0076
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0075
86 SEC14-like protein 4 SEC14L4 0.0075
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0075
375 SEC14-like protein 3 SEC14L3 0.0075
4076 Diacylglycerol kinase alpha DGKA 0.0075
1178 Adenosine A2a receptor ADORA2A 0.0074
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0074
3947 Xanthine dehydrogenase/oxidase XDH 0.0074
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0074
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0074
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0072
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0072
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0072
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0072
4116 Dihydropteroate synthetase Not Available 0.0072
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0072
130 Prostacyclin synthase PTGIS 0.0072
823 Fibroblast growth factor receptor 2 FGFR2 0.0072
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0072
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0072
1502 Peroxisome proliferator-activated receptor delta PPARD 0.007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.007
716 5-hydroxytryptamine 7 receptor HTR7 0.007
2077 Caspase-3 CASP3 0.0069
49 Endothelin B receptor EDNRB 0.0069
68 Cannabinoid receptor 1 CNR1 0.0069
65 Matrix metalloproteinase-9 Not Available 0.0068
3932 Glutathione S-transferase A2 GSTA2 0.0068
1192 Sulfotransferase 1A1 SULT1A1 0.0068
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
1050 Bile salt sulfotransferase SULT2A1 0.0067
295 Carbonic anhydrase 1 CA1 0.0067
708 Alpha-tocopherol transfer protein TTPA 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0065
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0065
283 SEC14-like protein 2 SEC14L2 0.0064
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0063
905 Glutathione transferase omega-1 GSTO1 0.0063
899 Glutathione S-transferase Mu 3 GSTM3 0.0063
133 Dihydropterate synthase sulI 0.0063
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0063
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0063
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0062
6141 Sodium/bile acid cotransporter SLC10A1 0.0062
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
869 Estrogen receptor beta ESR2 0.0061
1629 Transcription factor AP-1 JUN 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0061
474 Acetylcholinesterase ACHE 0.0061
1618 High affinity nerve growth factor receptor NTRK1 0.006
4152 Superoxide dismutase [Cu-Zn] SOD1 0.006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.006
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
997 Protein kinase C beta type PRKCB 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
810 Heme oxygenase 1 HMOX1 0.0059
3391 Heme oxygenase 1 pbsA1 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0059
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0059
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0059
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0058
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0057
94 5-hydroxytryptamine 4 receptor HTR4 0.0057
7 Nitric oxide synthase, inducible NOS2 0.0056
756 Sex hormone-binding globulin SHBG 0.0056
4122 Histone deacetylase 2 HDAC2 0.0056
1970 Protein kinase C alpha type PRKCA 0.0055
163 D(1B) dopamine receptor DRD5 0.0055
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0054
6020 Aldehyde oxidase AOX1 0.0053
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0053
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0053
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0053
1656 CYP2B protein CYP2B 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0053
365 Dihydrofolate reductase DHFR 0.0052
2381 Dihydrofolate reductase DFR1 0.0052
2833 Dihydrofolate reductase Not Available 0.0052
2931 Dihydrofolate reductase folA 0.0052
3544 Dihydrofolate reductase folA 0.0052
3682 Dihydrofolate reductase folA 0.0052
6642 Dihydrofolate reductase folA 0.0052
6756 Dihydrofolate reductase dfrA 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
29 Tubulin beta-1 chain TUBB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
284 DNA-directed RNA polymerase beta chain rpoB 0.0051
5773 DNA-directed RNA polymerase beta chain rpoB 0.0051
2021 Thrombomodulin THBD 0.0051
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0051
613 Atrial natriuretic peptide receptor A NPR1 0.005
357 Carbonic anhydrase 2 CA2 0.005
1039 Histone deacetylase 9 HDAC9 0.005
921 Glutamate receptor 2 GRIA2 0.0049
124 Histamine H2 receptor HRH2 0.0049
844 Epidermal growth factor receptor EGFR 0.0049
558 Solute carrier family 12 member 1 SLC12A1 0.0049
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0049
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0049
482 Glycine receptor subunit alpha-1 GLRA1 0.0048
634 Squalene monooxygenase SQLE 0.0047
7196 Squalene monooxygenase ERG1 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
814 Ryanodine receptor 1 RYR1 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
1353 DNA topoisomerase 1 TOP1 0.0045
3552 DNA topoisomerase 1 topA 0.0045
952 Dipeptidyl peptidase 4 DPP4 0.0045
528 5-hydroxytryptamine 1E receptor HTR1E 0.0044
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0044
1010 Cytochrome P450 51A1 CYP51A1 0.0044
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0044
518 Peroxidase/catalase T katG 0.0044
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0043
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0043
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0043
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0043
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
380 Cytochrome P450 17A1 CYP17A1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
165 FL cytokine receptor FLT3 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
5798 Mitogen-activated protein kinase 11 MAPK11 0.0042
3937 Fatty-acid amide hydrolase FAAH 0.0041
161 Tubulin beta chain TUBB 0.0041
312 Tubulin beta chain TUB2 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
106 Cannabinoid receptor 2 CNR2 0.0041
936 Ephrin type-A receptor 2 EPHA2 0.0041
856 Vitamin D3 receptor VDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
5787 Angiopoietin-1 receptor TEK 0.004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.004
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.004
3809 Estrogen-related receptor gamma ESRRG 0.0039
1541 Metalloproteinase mmp20 0.0039
88 Retinoic acid receptor RXR-beta RXRB 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6042 Prostaglandin reductase 2 PTGR2 0.0039
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0038
267 Plasminogen activator inhibitor 1 SERPINE1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6149 Solute carrier family 22 member 10 SLC22A10 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0038
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0037
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0037
1714 Mitogen-activated protein kinase 3 MAPK3 0.0037
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
6221 Steroid hormone receptor ERR1 ESRRA 0.0036
1792 Tissue-type plasminogen activator PLAT 0.0036
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
1374 Natriuretic peptides B NPPB 0.0034
1827 Gap junction alpha-1 protein GJA1 0.0034
1908 Vascular cell adhesion protein 1 VCAM1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
737 Mineralocorticoid receptor NR3C2 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0032
3808 Dihydropteroate synthase 2 folP2 0.0032
3601 Dihydropteroate synthase 1 folP1 0.0032
3807 Dihydropteroate synthase 1 folP1 0.0032
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
1313 Lactoylglutathione lyase GLO1 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3957 Adenosine deaminase ADA 0.0029
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
239 Coagulation factor X F10 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0028
6131 Carbonic anhydrase 14 CA14 0.0027
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
4192 DNA topoisomerase 2-beta TOP2B 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
563 Thyroid peroxidase TPO 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0026
5880 Thrombopoietin receptor MPL 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0025
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0025
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0025
537 ATP synthase delta chain, mitochondrial ATP5D 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
4943 Cytochrome c6 petJ 0.0024
4934 Cytochrome c-551 nirM 0.0024
5218 Cytochrome c-551 nirM 0.0024
4905 Cytochrome c2 Not Available 0.0024
4939 Cytochrome c2 cycA 0.0024
4964 Cytochrome c2 cycA 0.0024
4979 Cytochrome c2 cycA 0.0024
6673 Cytochrome c2 cycA 0.0024
4947 Bacterial hemoglobin vhb 0.0024
4916 Cyanoglobin glbN 0.0024
4994 Hemoglobin-like protein HbO glbO 0.0024
4954 Soluble cytochrome b558 Not Available 0.0024
4975 Cytochrome c-556 RPA3973 0.0024
4909 CooA protein cooA 0.0024
4942 Diheme cytochrome c napB napB 0.0024
3116 Bacterioferritin bfr 0.0024
4906 Bacterioferritin bfr 0.0024
4965 Bacterioferritin bfr 0.0024
4915 Cytochrome c-550 psbV 0.0024
4959 Cytochrome c-550 psbV 0.0024
5216 Cytochrome c-550 psbV 0.0024
4925 Cytochrome c-type protein SHP shp 0.0024
4981 Iron-starvation protein PigA pigA 0.0024
4936 Cytochrome c2 iso-2 Not Available 0.0024
4907 Cytochrome c-L moxG 0.0024
6865 Cytochrome c-L moxG 0.0024
4998 Hemoglobin-like protein yjbI yjbI 0.0024
4984 Neuroglobin NGB 0.0024
5000 HemO hemO 0.0024
4989 Cytochrome c551 peroxidase ccp 0.0024
5222 Cytochrome c551 peroxidase ccpA 0.0024
4935 Cytochrome c-554 cycA1 0.0024
644 Heme oxygenase 2 HMOX2 0.0024
4982 Heme oxygenase 2 pbsA2 0.0024
4764 Cytochrome P450 165C4 CYP165C4 0.0024
4999 Cytochrome P450 165B3 CYP165B3 0.0024
4961 Hemophore HasA hasA 0.0024
4971 Nonaheme cytochrome c hmcA 0.0024
4910 Cytoglobin CYGB 0.0024
4976 Apocytochrome f petA 0.0024
6407 Apocytochrome f petA 0.0024
4937 Cytochrome oxidase subunit II rcoxA 0.0024
4904 Cytochrome c family protein GSU1996 0.0024
4926 Heme-based aerotactic transducer hemAT hemAT 0.0024
4931 Cytochrome P450 167A1 CYP167A1 0.0024
4960 Putative cytochrome P450-family protein SCO7417 0.0024
4972 P450cin cinA 0.0024
4903 Methyl-accepting chemotaxis protein Tar4 0.0024
4922 Cytochrome c, putative SO_4144 0.0024
4952 Catalase/peroxidase katA 0.0024
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0024
4993 Hydroxylamine oxidoreductase hao1 0.0024
3093 Catalase HPII katE 0.0024
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4948 Cytochrome c-553 Not Available 0.0024
4923 Cytochrome c3 DvMF_2499 0.0024
4945 Cytochrome c3 Not Available 0.0024
4949 Cytochrome c3 DVU_3171 0.0024
4968 Cytochrome c3 cytc3 0.0024
4997 Cytochrome c3 SO_2727 0.0024
5219 Cytochrome c3 cyd 0.0024
4902 Nine-heme cytochrome c Ddes_2038 0.0024
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0024
3189 High-molecular-weight cytochrome c hmcA 0.0024
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
822 Aldose reductase AKR1B1 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
6432 Transporter snf 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
2207 Rhodopsin RHO 0.0022
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
2232 Interleukin-5 IL5 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2091 Endoplasmin HSP90B1 0.0021
164 Histamine H4 receptor HRH4 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
4386 Hemoglobin-like protein HbN glbN 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
1820 Beta-nerve growth factor NGF 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
1243 Cathepsin D CTSD 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
4311 tRNA TRDMT1 0.0019
4325 tRNA trmD 0.0019
4328 tRNA trmD 0.0019
976 Platelet glycoprotein IX GP9 0.0019
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0018
3221 Cytochrome c4 cc4 0.0018
4920 Peroxidase/catalase katG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0018
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0018
683 Potassium transporter GK0582 0.0018
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0018
2119 Cytochrome b5 CYB5A 0.0018
4037 Hypothetical protein GPX1 0.0018
4297 Hypothetical protein SP_1951 0.0018
4521 Hypothetical protein BC_2969 0.0018
4540 Hypothetical protein TM_1070 0.0018
4555 Hypothetical protein MT1739 0.0018
4569 Hypothetical protein mshD 0.0018
4578 Hypothetical protein PA3270 0.0018
4747 Hypothetical protein PA3967 0.0018
5177 Hypothetical protein TM_0096 0.0018
5194 Hypothetical protein PA1204 0.0018
5240 Hypothetical protein Rv2991 0.0018
5370 Hypothetical protein TM_1158 0.0018
5710 Hypothetical protein Tb927.5.1360 0.0018
4990 PpcA ppcA 0.0018
3570 Cytochrome P450 152A1 cypC 0.0018
4289 Cytochrome P450 TT_P0059 0.0018
6262 Cytochrome P450 staP 0.0018
4992 Cytochrome c peroxidase Not Available 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4988 Sulfite oxidase, mitochondrial SUOX 0.0018
2915 Sensor protein fixL fixL 0.0018
4944 Sensor protein fixL fixL 0.0018
3375 Acidic cytochrome c3 Not Available 0.0018
4385 Cytochrome c' Not Available 0.0018
4967 Cytochrome c' cycA 0.0018
5038 Cytochrome c' Not Available 0.0018
5223 Cytochrome c' cycP 0.0018
4813 Heme oxygenase hmuO 0.0017
5769 Heme oxygenase Not Available 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0017
2230 Catalase CAT 0.0017
3249 Catalase katA 0.0017
3625 Catalase katA 0.0017
4539 Catalase katA 0.0017
4941 Catalase katB 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
4773 Deoxycytidine kinase DCK 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0017
2298 Cytochrome P450-cam camC 0.0016
3830 Calreticulin CALR 0.0016
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
268 Adenosine A2b receptor ADORA2B 0.0015
291 Nitric-oxide synthase, endothelial NOS3 0.0015
3233 Bile acid receptor NR1H4 0.0015
3670 Soluble cytochrome b562 precursor cybC 0.0015
3411 Cytochrome P450 121 cyp121 0.0015
2617 Nitric oxide synthase oxygenase nos 0.0015
2701 Nitric oxide synthase oxygenase nos 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
3291 Cytochrome c-552 cycA 0.0015
4927 Cytochrome c-552 nrfA 0.0015
4938 Cytochrome c-552 cycA 0.0015
4953 Cytochrome c-552 nrfA 0.0015
5217 Cytochrome c-552 cycM 0.0015
3856 Fibroblast growth factor receptor 3 FGFR3 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
1341 Histamine H3 receptor HRH3 0.0014
2808 Chloramphenicol acetyltransferase 3 cat3 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
162 Retinoic acid receptor gamma-1 RARG 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0014
2972 6-deoxyerythronolide B hydroxylase eryF 0.0014
6859 Protein S100-A4 S100A4 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
2417 Chloramphenicol acetyltransferase cat 0.0013
3278 Chloramphenicol acetyltransferase cat 0.0013
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
4608 Putative cytochrome P450 SCO1207 0.0013
4963 Putative cytochrome P450 SCO2884 0.0013
6254 Putative cytochrome P450 SCO6998 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0013
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0013
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0013
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0013
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0013
517 Alcohol dehydrogenase 1C ADH1C 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
358 Cystathionine beta-synthase CBS 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1992 Vitamin D-binding protein GC 0.0012
693 Hemoglobin subunit beta HBB 0.0012
319 Opioid receptor, sigma 1 OPRS1 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
6268 Hydroxyacid oxidase 1 HAO1 0.0011
1630 Integrin beta-2 ITGB2 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
4217 Telomerase reverse transcriptase TERT 0.0011
469 Annexin A1 ANXA1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
174 Sigma 1-type opioid receptor SIGMAR1 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0009
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0009
3086 Plasmepsin-2 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3404 Exotoxin A eta 0.0008
1184 Interferon beta IFNB1 0.0008
572 Integrin alpha-L ITGAL 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6218 Pannexin-1 PANX1 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
798 Osteocalcin BGLAP 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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