Partner ID 213
Name Amiloride-sensitive sodium channel subunit alpha
Synonyms 630
Gene name SCNN1A
General function Involved in amiloride-sensitive sodium channel activity
Specific function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception
Gene sequence + ...

ATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTCATGAAGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAGCCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAGTTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAACCGCATGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGGCAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTCAACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTACCCGGAAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGACCTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTGCGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCCCGTCGAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAGGACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACATACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTGTCGAGGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTCGCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTCCACCACCCGATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCCATGCCTGGAATCAACAACGGTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATTCCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCCTTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGGAAGGAAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGATGTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTCCTGCTTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAGAACGTGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTCCAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAGCGTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAATGGGTCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAGAAATGGAGTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCCTCTGTCACGATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGCTCCTCGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATGTTCCTCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGGGGTGCTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCACCCCATGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCTCCCCCTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGTTCCTCCACCTGTCCTCTGGGGGGGCCCTGA

Protein sequence + ...

MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP

GO Classification
component
intrinsic to membrane
integral to membrane
membrane
cell
function
cation channel activity
transporter activity
sodium channel activity
amiloride-sensitive sodium channel activity
ion transporter activity
ion channel activity
process
cation transport
monovalent inorganic cation transport
physiological process
sodium ion transport
cellular physiological process
transport
ion transport
See more information at   →   www.drugbank.ca
Id Name
DB00384 Triamterene
DB00594 Amiloride
Id Name
DB00013 Urokinase
DB00030 Insulin Regular
DB00046 Insulin Lispro
DB00047 Insulin Glargine
DB00071 Insulin, porcine
DB00122 Choline
DB00123 L-Lysine
DB00125 L-Arginine
DB00127 Spermine
DB00152 Thiamine
DB00170 Menadione
DB00176 Fluvoxamine
DB00184 Nicotine
DB00188 Bortezomib
DB00191 Phentermine
DB00195 Betaxolol
DB00199 Erythromycin
DB00201 Caffeine
DB00206 Reserpine
DB00208 Ticlopidine
DB00213 Pantoprazole
DB00215 Citalopram
DB00220 Nelfinavir
DB00224 Indinavir
DB00238 Nevirapine
DB00242 Cladribine
DB00246 Ziprasidone
DB00257 Clotrimazole
DB00261 Anagrelide
DB00262 Carmustine
DB00264 Metoprolol
DB00268 Ropinirole
DB00277 Theophylline
DB00280 Disopyramide
DB00281 Lidocaine
DB00286 Conjugated Estrogens
DB00296 Ropivacaine
DB00297 Bupivacaine
DB00300 Tenofovir
DB00313 Valproic Acid
DB00315 Zolmitriptan
DB00316 Acetaminophen
DB00318 Codeine
DB00321 Amitriptyline
DB00325 Nitroprusside
DB00331 Metformin
DB00332 Ipratropium bromide
DB00333 Methadone
DB00334 Olanzapine
DB00338 Omeprazole
DB00339 Pyrazinamide
DB00345 Aminohippurate
DB00356 Chlorzoxazone
DB00357 Aminoglutethimide
DB00363 Clozapine
DB00365 Grepafloxacin
DB00368 Norepinephrine
DB00370 Mirtazapine
DB00377 Palonosetron
DB00379 Mexiletine
DB00381 Amlodipine
DB00382 Tacrine
DB00384 Triamterene
DB00388 Phenylephrine
DB00396 Progesterone
DB00397 Phenylpropanolamine
DB00398 Sorafenib
DB00400 Griseofulvin
DB00401 Nisoldipine
DB00406 Gentian Violet
DB00412 Rosiglitazone
DB00413 Pramipexole
DB00418 Secobarbital
DB00420 Promazine
DB00425 Zolpidem
DB00428 Streptozocin
DB00435 Nitric Oxide
DB00448 Lansoprazole
DB00457 Prazosin
DB00458 Imipramine
DB00461 Nabumetone
DB00467 Enoxacin
DB00468 Quinine
DB00472 Fluoxetine
DB00476 Duloxetine
DB00477 Chlorpromazine
DB00487 Pefloxacin
DB00495 Zidovudine
DB00499 Flutamide
DB00501 Cimetidine
DB00502 Haloperidol
DB00503 Ritonavir
DB00515 Cisplatin
DB00518 Albendazole
DB00520 Caspofungin
DB00523 Alitretinoin
DB00526 Oxaliplatin
DB00530 Erlotinib
DB00532 Mephenytoin
DB00533 Rofecoxib
DB00536 Guanidine
DB00537 Ciprofloxacin
DB00539 Toremifene
DB00540 Nortriptyline
DB00544 Fluorouracil
DB00549 Zafirlukast
DB00553 Methoxsalen
DB00564 Carbamazepine
DB00568 Cinnarizine
DB00570 Vinblastine
DB00571 Propranolol
DB00572 Atropine
DB00575 Clonidine
DB00583 L-Carnitine
DB00586 Diclofenac
DB00594 Amiloride
DB00604 Cisapride
DB00605 Sulindac
DB00607 Nafcillin
DB00615 Rifabutin
DB00619 Imatinib
DB00623 Fluphenazine
DB00624 Testosterone
DB00625 Efavirenz
DB00629 Guanabenz
DB00633 Dexmedetomidine
DB00654 Latanoprost
DB00655 Estrone
DB00661 Verapamil
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00673 Aprepitant
DB00675 Tamoxifen
DB00678 Losartan
DB00679 Thioridazine
DB00682 Warfarin
DB00683 Midazolam
DB00690 Flurazepam
DB00694 Daunorubicin
DB00696 Ergotamine
DB00697 Tizanidine
DB00705 Delavirdine
DB00709 Lamivudine
DB00724 Imiquimod
DB00728 Rocuronium
DB00730 Thiabendazole
DB00737 Meclizine
DB00738 Pentamidine
DB00740 Riluzole
DB00744 Zileuton
DB00745 Modafinil
DB00752 Tranylcypromine
DB00758 Clopidogrel
DB00763 Methimazole
DB00772 Malathion
DB00773 Etoposide
DB00778 Roxithromycin
DB00783 Estradiol
DB00787 Acyclovir
DB00788 Naproxen
DB00794 Primidone
DB00806 Pentoxifylline
DB00818 Propofol
DB00829 Diazepam
DB00831 Trifluoperazine
DB00850 Perphenazine
DB00851 Dacarbazine
DB00857 Terbinafine
DB00863 Ranitidine
DB00882 Clomifene
DB00898 Ethanol
DB00904 Ondansetron
DB00907 Cocaine
DB00908 Quinidine
DB00914 Phenformin
DB00915 Amantadine
DB00917 Dinoprostone
DB00918 Almotriptan
DB00921 Buprenorphine
DB00924 Cyclobenzaprine
DB00925 Phenoxybenzamine
DB00927 Famotidine
DB00934 Maprotiline
DB00951 Isoniazid
DB00953 Rizatriptan
DB00967 Desloratadine
DB00969 Alosetron
DB00972 Azelastine
DB00974 Edetic Acid
DB00976 Telithromycin
DB00978 Lomefloxacin
DB00980 Ramelteon
DB00987 Cytarabine
DB00988 Dopamine
DB00998 Frovatriptan
DB01002 Levobupivacaine
DB01004 Ganciclovir
DB01007 Tioconazole
DB01012 Cinacalcet
DB01013 Clobetasol
DB01026 Ketoconazole
DB01028 Methoxyflurane
DB01029 Irbesartan
DB01032 Probenecid
DB01035 Procainamide
DB01037 Selegiline
DB01041 Thalidomide
DB01043 Memantine
DB01045 Rifampin
DB01053 Penicillin G
DB01056 Tocainide
DB01058 Praziquantel
DB01059 Norfloxacin
DB01065 Melatonin
DB01075 Diphenhydramine
DB01079 Tegaserod
DB01087 Primaquine
DB01094 Hesperetin
DB01095 Fluvastatin
DB01097 Leflunomide
DB01100 Pimozide
DB01103 Quinacrine
DB01104 Sertraline
DB01110 Miconazole
DB01114 Chlorpheniramine
DB01115 Nifedipine
DB01118 Amiodarone
DB01129 Rabeprazole
DB01131 Proguanil
DB01136 Carvedilol
DB01137 Levofloxacin
DB01142 Doxepin
DB01151 Desipramine
DB01156 Bupropion
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01166 Cilostazol
DB01171 Moclobemide
DB01174 Phenobarbital
DB01182 Propafenone
DB01184 Domperidone
DB01191 Dexfenfluramine
DB01193 Acebutolol
DB01199 Tubocurarine
DB01200 Bromocriptine
DB01211 Clarithromycin
DB01217 Anastrozole
DB01223 Aminophylline
DB01232 Saquinavir
DB01241 Gemfibrozil
DB01242 Clomipramine
DB01254 Dasatinib
DB01283 Lumiracoxib
DB01303 Oxtriphylline
DB01306 Insulin Aspart
DB01307 Insulin Detemir
DB01309 Insulin Glulisine
DB01337 Pancuronium
DB01339 Vecuronium
DB01355 Hexobarbital
DB01367 Rasagiline
DB01388 Mibefradil
DB01403 Methotrimeprazine
DB01405 Temafloxacin
DB01407 Clenbuterol
DB01409 Tiotropium
DB01412 Theobromine
DB01418 Acenocoumarol
DB01424 Aminophenazone
DB01435 Antipyrine
DB01544 Flunitrazepam
DB01558 Bromazepam
DB01580 Oxprenolol
DB01601 Lopinavir
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01628 Etoricoxib
DB01645 Genistein
DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB01917 Putrescine
DB01977 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
DB02193 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB02398 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02473 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02526 CRA_10655
DB02533 Aminoguanidine
DB02551 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02624 Homoserine Lactone
DB02705 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02709 Resveratrol
DB03046 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
DB03082 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
DB03127 Benzamidine
DB03128 Acetylcholine
DB03136 4-Iodobenzo[B]Thiophene-2-Carboxamidine
DB03159 CRA_8696
DB03476 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
DB03566 Spermidine
DB03608 Diminazene
DB03729 2-Amino-5-Hydroxy-Benzimidazole
DB03782 N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea
DB03783 Phenacetin
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB03876 Thieno[2,3-B]Pyridine-2-Carboxamidine
DB04059 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
DB04172 [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
DB04348 Taurocholic Acid
DB04485 Deoxythymidine
DB04574 Estropipate
DB04816 Dantron
DB04830 Buformin
DB04841 Flunarizine
DB04871 Lorcaserin
DB04920 Clevidipine
DB04946 Iloperidone
DB05271 Rotigotine
DB06148 Mianserin
DB06210 Eltrombopag
DB06216 Asenapine
DB06589 Pazopanib
DB06594 Agomelatine
DB06605 Apixaban
DB06626 Axitinib
DB06691 Mepyramine
DB06712 Nilvadipine
DB06732 beta-Naphthoflavone
DB06770 Benzyl alcohol
DB06803 Niclosamide
DB06854 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB06855 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB06856 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
DB06857 N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
DB07076 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
DB07122 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
DB07129 (2R)-1-(2,6-dimethylphenoxy)propan-2-amine
DB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
DB07625 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
DB07626 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
DB08072 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
DB08697 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
DB08837 Tetraethylammonium
DB08838 Agmatine
DB08864 Rilpivirine
DB08881 Vemurafenib
DB08910 Pomalidomide