DT-Web

DB00740 - Riluzole


Identification
Name Riluzole
Accession Number DB00740 (APRD00145)
Type small molecule
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 234.198
Groups approved
Monoisotopic Weight 234.007468097
Pharmacology
Indication For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Mechanism of action The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release (activation of glutamate reuptake), 2) inactivation of voltage-dependent sodium channels, and 3) ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors.
Absorption Riluzole is well-absorbed (approximately 90%), with average absolute oral bioavailability of about 60% (CV=30%). A high fat meal decreases absorption, reducing AUC by about 20% and peak blood levels by about 45%.
Protein binding 96% bound to plasma proteins, mainly to albumin and lipoprotein over the clinical concentration range.
Biotransformation Riluzole is extensively metabolized to six major and a number of minor metabolites, which have not all been identified to date. Metabolism is mostly hepatic, consisting of cytochrome P450–dependent hydroxylation and glucuronidation. CYP1A2 is the primary isozyme involved in N-hydroxylation; CYP2D6, CYP2C19, CYP3A4, and CYP2E1 are considered unlikely to contribute significantly to riluzole metabolism in humans.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take on an empty stomach 1 hour before or 2 hours after meals.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Schwartz G, Fehlings MG: Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177-90. - Pubmed
  • Song JH, Huang CS, Nagata K, Yeh JZ, Narahashi T: Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther. 1997 Aug;282(2):707-14. - Pubmed
  • Weiss S, Benoist D, White E, Teng W, Saint DA: Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current. Br J Pharmacol. 2010 Jul;160(5):1072-82. - Pubmed
DTHybrid score 0.484
Cystine/glutamate transporter
Name Cystine/glutamate transporter
Gene Name SLC7A11
Pharmacological action yes
Actions inducer
References
  • Wokke J: Riluzole. Lancet. 1996 Sep 21;348(9030):795-9. - Pubmed
  • Azbill RD, Mu X, Springer JE: Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes. Brain Res. 2000 Jul 21;871(2):175-80. - Pubmed
  • Dunlop J, Beal McIlvain H, She Y, Howland DS: Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis. J Neurosci. 2003 Mar 1;23(5):1688-96. - Pubmed
  • Gosselin RD, O'Connor RM, Tramullas M, Julio-Pieper M, Dinan TG, Cryan JF: Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms. Gastroenterology. 2010 Jun;138(7):2418-25. Epub 2010 Mar 10. - Pubmed
  • Hayashida K, Parker RA, Eisenach JC: Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res. 2010 Mar 4;1317:80-6. Epub 2010 Jan 6. - Pubmed
DTHybrid score 0.2558

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.345
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2322

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Milane A, Vautier S, Chacun H, Meininger V, Bensimon G, Farinotti R, Fernandez C: Interactions between riluzole and ABCG2/BCRP transporter. Neurosci Lett. 2009 Mar 6;452(1):12-6. Epub 2009 Jan 6. - Pubmed
DTHybrid score 0.2262

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.181
4119 Cytochrome P450 2D6 CYP2D6 0.1579
1588 Multidrug resistance protein 1 ABCB1 0.1333
4757 Cytochrome P450 2C9 CYP2C9 0.1315
6016 Cytochrome P450 2C19 CYP2C19 0.1287
4118 Cytochrome P450 3A5 CYP3A5 0.1
4924 Cytochrome P450 2C8 CYP2C8 0.0944
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0864
6030 Cytochrome P450 2B6 CYP2B6 0.0779
6013 Cytochrome P450 2E1 CYP2E1 0.0735
587 Serum albumin ALB 0.0602
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0564
6107 Cytochrome P450 3A7 CYP3A7 0.0538
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0505
862 Multidrug resistance-associated protein 1 ABCC1 0.0493
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0491
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0487
38 Cystinosin CTNS 0.0485
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0485
5718 Cytochrome P450 2A6 CYP2A6 0.048
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0472
1898 Cytochrome P450 1B1 CYP1B1 0.0472
776 Bile salt export pump ABCB11 0.0371
20 Prostaglandin G/H synthase 1 PTGS1 0.0352
6145 Solute carrier family 22 member 1 SLC22A1 0.0343
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0312
6144 Solute carrier family 22 member 2 SLC22A2 0.03
465 Calmodulin CALM1 0.0276
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0273
1729 Solute carrier family 22 member 6 SLC22A6 0.0271
290 Prostaglandin G/H synthase 2 PTGS2 0.0259
36 Insulin receptor INSR 0.0258
6151 Monocarboxylate transporter 10 SLC16A10 0.0258
2164 Multidrug resistance-associated protein 4 ABCC4 0.0255
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0246
6106 Cytochrome P450 2C18 CYP2C18 0.024
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0233
118 Organic cation/carnitine transporter 2 SLC22A5 0.0222
1650 Heme carrier protein 1 SLC46A1 0.0216
844 Epidermal growth factor receptor EGFR 0.0213
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.021
817 DNA topoisomerase 2-alpha TOP2A 0.0208
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0207
6148 Multidrug resistance-associated protein 7 ABCC10 0.0204
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0201
6142 Solute carrier family 22 member 8 SLC22A8 0.0197
6220 Aryl hydrocarbon receptor AHR 0.0195
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0193
6147 Solute carrier family 22 member 3 SLC22A3 0.0193
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.019
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0184
468 Cytochrome P450 4A11 CYP4A11 0.0181
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.018
3923 Cholinesterase BCHE 0.0175
136 Estrogen receptor ESR1 0.0173
3811 Cytochrome P450 19A1 CYP19A1 0.017
275 Arachidonate 5-lipoxygenase ALOX5 0.0169
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0165
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0165
172 Potassium channel subfamily K member 1 KCNK1 0.0163
318 Alpha-2A adrenergic receptor ADRA2A 0.0157
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0155
833 Organic cation/carnitine transporter 1 SLC22A4 0.0154
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0152
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0151
3941 Amine oxidase [flavin-containing] A MAOA 0.0148
824 Sodium-dependent serotonin transporter SLC6A4 0.0145
477 DNA topoisomerase 4 subunit A parC 0.0144
886 DNA topoisomerase 4 subunit A parC 0.0144
6226 DNA topoisomerase 4 subunit A parC 0.0144
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0142
404 DNA gyrase subunit A gyrA 0.0141
6224 DNA gyrase subunit A gyrA 0.0141
492 Histamine H1 receptor HRH1 0.0141
617 Muscarinic acetylcholine receptor M2 CHRM2 0.014
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0139
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0135
193 Beta-1 adrenergic receptor ADRB1 0.013
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.013
6014 Cytochrome P450 2A13 CYP2A13 0.0127
504 Mast/stem cell growth factor receptor KIT 0.0127
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0126
6137 Multidrug resistance-associated protein 6 ABCC6 0.0123
885 5-hydroxytryptamine 1B receptor HTR1B 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
777 Tumor necrosis factor TNF 0.0121
831 D(2) dopamine receptor DRD2 0.012
117 Sterol O-acyltransferase 1 SOAT1 0.012
556 Alpha-1A adrenergic receptor ADRA1A 0.012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.012
502 5-hydroxytryptamine 2A receptor HTR2A 0.0118
6141 Sodium/bile acid cotransporter SLC10A1 0.0116
48 Pyridoxal kinase PDXK 0.0116
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0108
921 Glutamate receptor 2 GRIA2 0.0106
6143 Solute carrier family 22 member 7 SLC22A7 0.0105
613 Atrial natriuretic peptide receptor A NPR1 0.0105
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0104
766 Beta-2 adrenergic receptor ADRB2 0.0102
228 Beta platelet-derived growth factor receptor PDGFRB 0.0102
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0102
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0102
738 Monocarboxylate transporter 1 SLC16A1 0.0102
23 D(1A) dopamine receptor DRD1 0.0101
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.01
590 5-hydroxytryptamine 2C receptor HTR2C 0.01
725 5-hydroxytryptamine 1D receptor HTR1D 0.0099
1757 Myeloperoxidase MPO 0.0099
341 5-hydroxytryptamine 3 receptor HTR3A 0.0098
3947 Xanthine dehydrogenase/oxidase XDH 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0096
992 Protein tyrosine kinase 2 beta PTK2B 0.0095
6167 Organic solute transporter subunit beta OSTB 0.0095
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0095
6166 Organic solute transporter subunit alpha OSTA 0.0094
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0094
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0094
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0094
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0094
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
713 Sodium-dependent dopamine transporter SLC6A3 0.0093
320 5-hydroxytryptamine 1A receptor HTR1A 0.0092
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0092
1517 Beta-3 adrenergic receptor ADRB3 0.0091
3587 Gastrotropin FABP6 0.0091
871 Glucocorticoid receptor NR3C1 0.009
16 Adenosine A1 receptor ADORA1 0.009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0088
632 Alpha-1B adrenergic receptor ADRA1B 0.0088
1024 Solute carrier family 22 member 11 SLC22A11 0.0087
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0087
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0086
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0086
2449 Tubulin alpha-3 chain TUBA1A 0.0086
790 DNA polymerase subunit alpha B POLA2 0.0084
3939 Amine oxidase [flavin-containing] B MAOB 0.0083
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0081
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.008
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.008
6146 High affinity copper uptake protein 1 SLC31A1 0.008
629 Alpha-2B adrenergic receptor ADRA2B 0.0078
1178 Adenosine A2a receptor ADORA2A 0.0076
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
789 Alpha-1D adrenergic receptor ADRA1D 0.0076
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0075
26 Vascular endothelial growth factor receptor 3 FLT4 0.0075
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
869 Estrogen receptor beta ESR2 0.0074
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0074
4120 NADPH--cytochrome P450 reductase POR 0.0074
32 Vascular endothelial growth factor receptor 1 FLT1 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
908 Glutathione S-transferase theta-1 GSTT1 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
407 Vascular endothelial growth factor receptor 2 KDR 0.0068
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0067
461 Glycine receptor subunit alpha-3 GLRA3 0.0067
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0067
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0066
638 D(3) dopamine receptor DRD3 0.0066
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0066
571 Melatonin receptor type 1A MTNR1A 0.0066
362 Melatonin receptor type 1B MTNR1B 0.0066
378 Alpha-2C adrenergic receptor ADRA2C 0.0065
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0065
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0065
373 Transthyretin TTR 0.0064
1820 Beta-nerve growth factor NGF 0.0064
4228 Keratin, type II cytoskeletal 7 KRT7 0.0063
904 Glutathione S-transferase P GSTP1 0.0063
511 5-hydroxytryptamine 1F receptor HTR1F 0.0062
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0061
273 Apoptosis regulator Bcl-2 BCL2 0.0061
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.006
6163 Copper-transporting ATPase 2 ATP7B 0.006
6165 Copper-transporting ATPase 1 ATP7A 0.006
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
731 HIV-1 protease HIV-1 protease 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
820 Glycine receptor subunit alpha-2 GLRA2 0.0056
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0056
3426 Glutamine synthetase glnA 0.0056
3987 Glutamine synthetase GLUL 0.0056
756 Sex hormone-binding globulin SHBG 0.0055
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
106 Cannabinoid receptor 2 CNR2 0.0054
823 Fibroblast growth factor receptor 2 FGFR2 0.0053
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0053
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
3917 Methylenetetrahydrofolate reductase MTHFR 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
1714 Mitogen-activated protein kinase 3 MAPK3 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0051
68 Cannabinoid receptor 1 CNR1 0.0051
6136 Multidrug resistance-associated protein 5 ABCC5 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0049
4192 DNA topoisomerase 2-beta TOP2B 0.0049
896 Glutathione S-transferase Mu 1 GSTM1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
1010 Cytochrome P450 51A1 CYP51A1 0.0049
6020 Aldehyde oxidase AOX1 0.0048
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0048
3932 Glutathione S-transferase A2 GSTA2 0.0047
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0047
6182 Cytochrome P450 2J2 CYP2J2 0.0047
70 Type-1 angiotensin II receptor AGTR1 0.0047
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0046
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0045
936 Ephrin type-A receptor 2 EPHA2 0.0045
2539 Tubulin alpha-1 chain TUBA4A 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
432 D(4) dopamine receptor DRD4 0.0044
165 FL cytokine receptor FLT3 0.0044
4604 Liver carboxylesterase 1 CES1 0.0044
6031 Cytochrome P450 3A43 CYP3A43 0.0044
751 Potassium channel subfamily K member 6 KCNK6 0.0044
183 Vascular endothelial growth factor A VEGFA 0.0043
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1192 Sulfotransferase 1A1 SULT1A1 0.0042
3856 Fibroblast growth factor receptor 3 FGFR3 0.0041
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0041
1063 Signal transducer and activator of transcription 5B STAT5B 0.0041
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0041
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0039
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
4311 tRNA TRDMT1 0.0039
4325 tRNA trmD 0.0039
4328 tRNA trmD 0.0039
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0039
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0039
469 Annexin A1 ANXA1 0.0039
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0038
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
146 Androgen receptor AR 0.0038
380 Cytochrome P450 17A1 CYP17A1 0.0038
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
122 P2Y purinoceptor 12 P2RY12 0.0037
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0037
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0037
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0036
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
2236 Casein kinase II subunit alpha CSNK2A1 0.0035
239 Coagulation factor X F10 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0034
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0034
1912 Excitatory amino acid transporter 1 SLC1A3 0.0034
4019 Excitatory amino acid transporter 4 SLC1A6 0.0034
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0034
4026 Aspartyl aminopeptidase DNPEP 0.0034
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0034
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0034
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0034
4016 Excitatory amino acid transporter 5 SLC1A7 0.0034
4017 5-oxoprolinase OPLAH 0.0034
1047 Excitatory amino acid transporter 2 SLC1A2 0.0034
922 Glutamate receptor 4 GRIA4 0.0034
664 Glutamate decarboxylase 2 GAD2 0.0034
3890 Glutamate decarboxylase 2 GAD2 0.0034
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0034
4020 Glutamyl aminopeptidase ENPEP 0.0034
4027 Glutamate receptor delta-1 subunit GRID1 0.0034
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0034
927 Metabotropic glutamate receptor 8 GRM8 0.0034
925 Metabotropic glutamate receptor 4 GRM4 0.0034
926 Metabotropic glutamate receptor 7 GRM7 0.0034
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0034
4018 Glutamate receptor delta-2 subunit GRID2 0.0034
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0034
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0034
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0033
484 Tyrosine-protein kinase ABL2 ABL2 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
6131 Carbonic anhydrase 14 CA14 0.0032
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0032
84 Nuclear receptor 0B1 NR0B1 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0032
3957 Adenosine deaminase ADA 0.0032
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0032
295 Carbonic anhydrase 1 CA1 0.0032
293 Gamma-glutamyl hydrolase GGH 0.0031
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0031
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0031
1629 Transcription factor AP-1 JUN 0.0031
625 Glutamate carboxypeptidase 2 FOLH1 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
818 50S ribosomal protein L10 rplJ 0.003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.003
260 Cytochrome P450 51 ERG11 0.003
761 Cytochrome P450 51 ERG11 0.003
3163 Cytochrome P450 51 cyp51 0.003
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.003
6122 Carbonic anhydrase 3 CA3 0.003
173 Toll-like receptor 7 TLR7 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.003
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.003
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0029
5 Glutaminase liver isoform, mitochondrial GLS2 0.0029
917 Glutaminase kidney isoform, mitochondrial GLS 0.0029
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0029
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0029
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0029
5261 Phosphoribosylformylglycinamidine synthase purL 0.0029
705 Glutamate receptor 1 GRIA1 0.0029
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0029
2112 Toll-like receptor 9 TLR9 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
3810 Catechol O-methyltransferase COMT 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0028
665 Phosphoserine aminotransferase PSAT1 0.0028
4652 Phosphoserine aminotransferase serC 0.0028
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0028
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0028
420 Glutamate decarboxylase 1 GAD1 0.0028
3900 Glutamate decarboxylase 1 GAD1 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0028
916 Metabotropic glutamate receptor 1 GRM1 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
3007 Carbonic anhydrase 12 CA12 0.0028
4205 Carbonic anhydrase 9 CA9 0.0028
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0028
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0027
5626 Nucleoside diphosphate kinase B NME2 0.0027
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0027
923 Glutamate receptor 3 GRIA3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0027
1671 Excitatory amino acid transporter 3 SLC1A1 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
3809 Estrogen-related receptor gamma ESRRG 0.0026
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
3877 Growth-inhibiting protein 18 GIG18 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0026
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0026
426 Aspartate aminotransferase, mitochondrial GOT2 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6102 Arylamine N-acetyltransferase 2 NAT2 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0025
763 Tyrosine aminotransferase TAT 0.0025
5493 Tyrosine aminotransferase Not Available 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
976 Platelet glycoprotein IX GP9 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0024
1374 Natriuretic peptides B NPPB 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0024
6228 Nuclear receptor coactivator 1 NCOA1 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
716 5-hydroxytryptamine 7 receptor HTR7 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0024
4102 Proteasome subunit beta type 5 PSMB5 0.0024
4101 Proteasome subunit beta type 1 PSMB1 0.0024
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0024
6241 Nuclear receptor coactivator 2 NCOA2 0.0024
6070 Nischarin NISCH 0.0024
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
6134 Sodium channel subunit beta-3 SCN3B 0.0024
6132 Sodium channel subunit beta-1 SCN1B 0.0024
6135 Sodium channel subunit beta-4 SCN4B 0.0024
6127 Carbonic anhydrase-related protein CA8 0.0024
6133 Sodium channel subunit beta-2 SCN2B 0.0024
6128 Carbonic anhydrase-related protein 10 CA10 0.0024
6129 Carbonic anhydrase-related protein 11 CA11 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
847 Mu-type opioid receptor OPRM1 0.0023
814 Ryanodine receptor 1 RYR1 0.0023
822 Aldose reductase AKR1B1 0.0023
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0023
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0023
4225 Uridine phosphorylase 1 UPP1 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0022
696 Kappa-type opioid receptor OPRK1 0.0022
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
1256 5-hydroxytryptamine 6 receptor HTR6 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
634 Squalene monooxygenase SQLE 0.0022
7196 Squalene monooxygenase ERG1 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
251 Alcohol dehydrogenase 1A ADH1A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0021
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0021
592 Carbonic anhydrase 4 CA4 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
7 Nitric oxide synthase, inducible NOS2 0.0021
413 Amidophosphoribosyltransferase PPAT 0.0021
2515 Amidophosphoribosyltransferase purF 0.0021
3714 Amidophosphoribosyltransferase purF 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
467 Delta-type opioid receptor OPRD1 0.0021
268 Adenosine A2b receptor ADORA2B 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
24 Thymidylate synthase TMP1 0.002
359 Thymidylate synthase TYMS 0.002
2626 Thymidylate synthase thyA 0.002
2729 Thymidylate synthase thyA 0.002
5352 Thymidylate synthase THYA 0.002
6130 Carbonic anhydrase 13 CA13 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
124 Histamine H2 receptor HRH2 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
1864 RET proto-oncogene RET 0.0018
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
1992 Vitamin D-binding protein GC 0.0018
760 Fibroblast growth factor 1 FGF1 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
6085 Fatty acid-binding protein, intestinal FABP2 0.0018
88 Retinoic acid receptor RXR-beta RXRB 0.0018
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
3639 Thymidine phosphorylase deoA 0.0017
3936 Thymidine phosphorylase TYMP 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
1648 Elastin ELN 0.0017
1275 Estrogen sulfotransferase SULT1E1 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
1656 CYP2B protein CYP2B 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
161 Tubulin beta chain TUBB 0.0016
312 Tubulin beta chain TUB2 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
1830 5'-nucleotidase NT5E 0.0016
798 Osteocalcin BGLAP 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
1050 Bile salt sulfotransferase SULT2A1 0.0016
1243 Cathepsin D CTSD 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
474 Acetylcholinesterase ACHE 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
427 Substance-P receptor TACR1 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
702 UMP-CMP kinase CMPK1 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
6432 Transporter snf 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0013
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0013
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0013
856 Vitamin D3 receptor VDR 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
997 Protein kinase C beta type PRKCB 0.0012
737 Mineralocorticoid receptor NR3C2 0.0012
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
518 Peroxidase/catalase T katG 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
563 Thyroid peroxidase TPO 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
614 Progesterone receptor PGR 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
4237 50S ribosomal protein L22 rplV 0.001
5818 Folate receptor alpha FOLR1 0.001
345 Plasma retinol-binding protein RBP4 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
164 Histamine H4 receptor HRH4 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
54 Prothrombin F2 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
811 Translocator protein TSPO 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
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