DT-Web

DB01337 - Pancuronium


Identification
Name Pancuronium
Accession Number DB01337
Type small molecule
Description A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 572.8619
Groups approved
Monoisotopic Weight 572.455308418
Pharmacology
Indication Used as a muscle relaxant during anesthesia and surgical procedures.
Mechanism of action Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents.
Absorption Not Available
Protein binding 77 to 91%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin The agent increases the effect of muscle relaxant
Aminophylline Theophylline decreases the effect of muscle relaxant
Azathioprine The agent decreases the effect of the muscle relaxant
Carbamazepine Decreases the effect of muscle relaxant
Clindamycin The agent increases the effect of muscle relaxant
Colistimethate Colistimethate may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. If possible, avoid concomitant use of these products. Monitor for deeper, prolonged neuromuscular-blocking effects (respiratory paralysis) in patients receiving concomitant neuromuscular-blocking agents and polymyxin antibiotics (e.g., colistimethate, polymyxin B).
Fosphenytoin Phenytoin decreases the effect of muscle relaxant
Gentamicin The agent increases the effect of muscle relaxant
Lincomycin The agent increases the effect of muscle relaxant
Mercaptopurine The agent dereases the effect of the muscle relaxant
Netilmicin The agent increases the effect of muscle relaxant
Oxtriphylline Theophylline decreases the effect of muscle relaxant
Phenytoin Phenytoin decreases the effect of the muscle relaxant
Piperacillin The agent increases the effect of the muscle relaxant
Quinidine The quinine derivative increases the effect of the muscle relaxant
Quinine The quinine derivative increases the effect of the muscle relaxant
Theophylline Theophylline decreases the effect of the muscle relaxant
Tobramycin The agent increases the effect of the muscle relaxant
Food Interactions Not Available

Targets


Neuronal acetylcholine receptor subunit alpha-2
Name Neuronal acetylcholine receptor subunit alpha-2
Gene Name CHRNA2
Pharmacological action yes
Actions antagonist
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Dilger JP, Vidal AM, Liu M, Mettewie C, Suzuki T, Pham A, Demazumder D: Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists. Anesthesiology. 2007 Jun;106(6):1186-95. - Pubmed
  • Jonsson Fagerlund M, Dabrowski M, Eriksson LI: Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. - Pubmed
DTHybrid score 0.6781
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Milchert M, Spassov A, Meissner K, Nedeljkov V, Lehmann C, Wendt M, Loster BW, Mazurkiewicz-Janik M, Gedrange T, Pavlovic D: Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro. J Physiol Pharmacol. 2009 Dec;60 Suppl 8:5-11. - Pubmed
  • Cembala TM, Forde SC, Appadu BL, Lambert DG: Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors. Eur J Pharmacol. 2007 Aug 13;569(1-2):37-40. Epub 2007 May 22. - Pubmed
  • Okanlami OA, Fryer AD, Hirshman C: Interaction of nondepolarizing muscle relaxants with M2 and M3 muscarinic receptors in guinea pig lung and heart. Anesthesiology. 1996 Jan;84(1):155-61. - Pubmed
DTHybrid score 0.5594
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Milchert M, Spassov A, Meissner K, Nedeljkov V, Lehmann C, Wendt M, Loster BW, Mazurkiewicz-Janik M, Gedrange T, Pavlovic D: Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro. J Physiol Pharmacol. 2009 Dec;60 Suppl 8:5-11. - Pubmed
  • Okanlami OA, Fryer AD, Hirshman C: Interaction of nondepolarizing muscle relaxants with M2 and M3 muscarinic receptors in guinea pig lung and heart. Anesthesiology. 1996 Jan;84(1):155-61. - Pubmed
DTHybrid score 0.4656

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Stovner J, Oftedal N, Holmboe J: The inhibition of cholinesterases by pancuronium. Br J Anaesth. 1975 Sep;47(9):949-54. - Pubmed
DTHybrid score 0.69

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate,inhibitor
References
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
  • Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score 0.3119
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions Not Available
References
  • Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. - Pubmed
DTHybrid score 0.2371

Predictions


Id Partner name Gene Name Score
103 Muscarinic acetylcholine receptor M1 CHRM1 0.3347
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1872
474 Acetylcholinesterase ACHE 0.1548
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1431
4119 Cytochrome P450 2D6 CYP2D6 0.1205
1588 Multidrug resistance protein 1 ABCB1 0.1171
4512 Cytochrome P450 3A4 CYP3A4 0.113
6147 Solute carrier family 22 member 3 SLC22A3 0.0697
118 Organic cation/carnitine transporter 2 SLC22A5 0.0692
341 5-hydroxytryptamine 3 receptor HTR3A 0.0666
492 Histamine H1 receptor HRH1 0.0654
833 Organic cation/carnitine transporter 1 SLC22A4 0.0633
4200 Cytochrome P450 1A2 CYP1A2 0.0628
6016 Cytochrome P450 2C19 CYP2C19 0.0525
556 Alpha-1A adrenergic receptor ADRA1A 0.0517
766 Beta-2 adrenergic receptor ADRB2 0.0482
831 D(2) dopamine receptor DRD2 0.048
4757 Cytochrome P450 2C9 CYP2C9 0.0476
502 5-hydroxytryptamine 2A receptor HTR2A 0.0476
4118 Cytochrome P450 3A5 CYP3A5 0.043
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0419
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0417
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0373
23 D(1A) dopamine receptor DRD1 0.0365
6030 Cytochrome P450 2B6 CYP2B6 0.0362
6013 Cytochrome P450 2E1 CYP2E1 0.0337
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0337
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0323
632 Alpha-1B adrenergic receptor ADRA1B 0.0312
6142 Solute carrier family 22 member 8 SLC22A8 0.031
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0307
6107 Cytochrome P450 3A7 CYP3A7 0.0304
4924 Cytochrome P450 2C8 CYP2C8 0.0295
590 5-hydroxytryptamine 2C receptor HTR2C 0.029
789 Alpha-1D adrenergic receptor ADRA1D 0.0282
318 Alpha-2A adrenergic receptor ADRA2A 0.0266
723 Cytosolic phospholipase A2 PLA2G4A 0.0264
378 Alpha-2C adrenergic receptor ADRA2C 0.0261
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0253
824 Sodium-dependent serotonin transporter SLC6A4 0.0252
124 Histamine H2 receptor HRH2 0.0251
638 D(3) dopamine receptor DRD3 0.0238
713 Sodium-dependent dopamine transporter SLC6A3 0.0238
629 Alpha-2B adrenergic receptor ADRA2B 0.0235
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0235
6024 Cytochrome P450 1A1 CYP1A1 0.0231
320 5-hydroxytryptamine 1A receptor HTR1A 0.0227
587 Serum albumin ALB 0.0223
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0221
193 Beta-1 adrenergic receptor ADRB1 0.0217
1729 Solute carrier family 22 member 6 SLC22A6 0.0213
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0207
432 D(4) dopamine receptor DRD4 0.0199
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0196
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0196
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0194
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
3076 Antigen 85-C fbpC 0.0187
5718 Cytochrome P450 2A6 CYP2A6 0.0174
776 Bile salt export pump ABCB11 0.0168
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
862 Multidrug resistance-associated protein 1 ABCC1 0.0164
6010 Thiamine transporter 1 SLC19A2 0.0159
465 Calmodulin CALM1 0.0151
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0147
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
436 5-hydroxytryptamine 2B receptor HTR2B 0.0146
6143 Solute carrier family 22 member 7 SLC22A7 0.0143
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
3454 Esterase estA 0.0141
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0139
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0139
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0138
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
163 D(1B) dopamine receptor DRD5 0.0136
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
6106 Cytochrome P450 2C18 CYP2C18 0.0129
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0128
20 Prostaglandin G/H synthase 1 PTGS1 0.0127
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
4773 Deoxycytidine kinase DCK 0.0124
131 Synaptic vesicular amine transporter SLC18A2 0.0123
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0119
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
290 Prostaglandin G/H synthase 2 PTGS2 0.0113
885 5-hydroxytryptamine 1B receptor HTR1B 0.0109
7 Nitric oxide synthase, inducible NOS2 0.0109
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0108
2129 Sucrase-isomaltase, intestinal SI 0.0106
3939 Amine oxidase [flavin-containing] B MAOB 0.0101
244 Angiotensin-converting enzyme ACE 0.0101
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.01
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0099
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
725 5-hydroxytryptamine 1D receptor HTR1D 0.0096
6148 Multidrug resistance-associated protein 7 ABCC10 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0094
528 5-hydroxytryptamine 1E receptor HTR1E 0.0093
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0092
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.009
6070 Nischarin NISCH 0.0089
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0086
1256 5-hydroxytryptamine 6 receptor HTR6 0.0086
694 Matrix protein 2 M 0.0086
1898 Cytochrome P450 1B1 CYP1B1 0.0085
6432 Transporter snf 0.0085
1517 Beta-3 adrenergic receptor ADRB3 0.0085
4203 Histamine N-methyltransferase HNMT 0.0083
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0081
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0079
275 Arachidonate 5-lipoxygenase ALOX5 0.0079
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0079
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0079
716 5-hydroxytryptamine 7 receptor HTR7 0.0078
3811 Cytochrome P450 19A1 CYP19A1 0.0078
1830 5'-nucleotidase NT5E 0.0077
2164 Multidrug resistance-associated protein 4 ABCC4 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
164 Histamine H4 receptor HRH4 0.0076
6137 Multidrug resistance-associated protein 6 ABCC6 0.0076
125 DNA polymerase beta POLB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0072
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
6171 Solute carrier family 28 member 3 SLC28A3 0.007
737 Mineralocorticoid receptor NR3C2 0.007
828 Phenylalanine-4-hydroxylase PAH 0.0068
3109 Phenylalanine-4-hydroxylase phhA 0.0068
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0067
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0065
85 Growth hormone receptor GHR 0.0065
5126 Arginase rocF 0.0064
614 Progesterone receptor PGR 0.0064
6165 Copper-transporting ATPase 1 ATP7A 0.0062
6163 Copper-transporting ATPase 2 ATP7B 0.0062
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.006
1341 Histamine H3 receptor HRH3 0.006
319 Opioid receptor, sigma 1 OPRS1 0.006
3941 Amine oxidase [flavin-containing] A MAOA 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
6146 High affinity copper uptake protein 1 SLC31A1 0.0059
1360 Sphingomyelin phosphodiesterase SMPD1 0.0059
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0057
477 DNA topoisomerase 4 subunit A parC 0.0056
886 DNA topoisomerase 4 subunit A parC 0.0056
6226 DNA topoisomerase 4 subunit A parC 0.0056
908 Glutathione S-transferase theta-1 GSTT1 0.0056
404 DNA gyrase subunit A gyrA 0.0055
6224 DNA gyrase subunit A gyrA 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0053
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0053
3926 Choline transporter-like protein 2 SLC44A2 0.0053
3927 Choline transporter-like protein 3 SLC44A3 0.0053
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0053
861 Choline kinase alpha CHKA 0.0053
1686 Choline transporter-like protein 1 SLC44A1 0.0053
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0053
3925 Choline transporter-like protein 4 SLC44A4 0.0053
769 High-affinity choline transporter 1 SLC5A7 0.0053
700 Choline dehydrogenase, mitochondrial CHDH 0.0053
576 Choline O-acetyltransferase CHAT 0.0053
3922 Phospholipase D2 PLD2 0.0053
3924 Phospholipase D1 PLD1 0.0053
756 Sex hormone-binding globulin SHBG 0.0053
468 Cytochrome P450 4A11 CYP4A11 0.0053
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0051
467 Delta-type opioid receptor OPRD1 0.0051
904 Glutathione S-transferase P GSTP1 0.0051
696 Kappa-type opioid receptor OPRK1 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
215 Sodium channel protein type 11 subunit alpha SCN11A 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
136 Estrogen receptor ESR1 0.005
896 Glutathione S-transferase Mu 1 GSTM1 0.005
174 Sigma 1-type opioid receptor SIGMAR1 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
1618 High affinity nerve growth factor receptor NTRK1 0.0048
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0048
731 HIV-1 protease HIV-1 protease 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
1656 CYP2B protein CYP2B 0.0047
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0047
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0047
146 Androgen receptor AR 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
976 Platelet glycoprotein IX GP9 0.0046
1757 Myeloperoxidase MPO 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0045
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0045
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0044
612 P protein [Includes: DNA-directed DNA polymerase P 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0041
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
817 DNA topoisomerase 2-alpha TOP2A 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0039
869 Estrogen receptor beta ESR2 0.0039
5626 Nucleoside diphosphate kinase B NME2 0.0038
702 UMP-CMP kinase CMPK1 0.0037
527 Prostacyclin receptor PTGIR 0.0036
871 Glucocorticoid receptor NR3C1 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
6167 Organic solute transporter subunit beta OSTB 0.0036
6166 Organic solute transporter subunit alpha OSTA 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
847 Mu-type opioid receptor OPRM1 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
1864 RET proto-oncogene RET 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0033
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0033
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
153 Dopamine beta-hydroxylase DBH 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1178 Adenosine A2a receptor ADORA2A 0.0031
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.003
3437 Eosinophil lysophospholipase CLC 0.003
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.003
6218 Pannexin-1 PANX1 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.003
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0028
6182 Cytochrome P450 2J2 CYP2J2 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0027
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0027
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0027
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0026
3810 Catechol O-methyltransferase COMT 0.0025
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0025
228 Beta platelet-derived growth factor receptor PDGFRB 0.0025
4217 Telomerase reverse transcriptase TERT 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
380 Cytochrome P450 17A1 CYP17A1 0.0024
1629 Transcription factor AP-1 JUN 0.0024
2207 Rhodopsin RHO 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
504 Mast/stem cell growth factor receptor KIT 0.0023
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
161 Tubulin beta chain TUBB 0.0021
312 Tubulin beta chain TUB2 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.002
102 DNA topoisomerase I, mitochondrial TOP1MT 0.002
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0018
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0017
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0017
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0017
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0017
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0017
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0017
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0017
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0017
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
4604 Liver carboxylesterase 1 CES1 0.0016
4120 NADPH--cytochrome P450 reductase POR 0.0016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0016
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0014
4498 Ornithine cyclodeaminase PP3533 0.0012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0012
3587 Gastrotropin FABP6 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
3356 Diaminopimelate decarboxylase lysA 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
577 Argininosuccinate lyase ASL 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
1615 Chymase CMA1 0.0009
6031 Cytochrome P450 3A43 CYP3A43 0.0009
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1243 Cathepsin D CTSD 0.0005
1439 Lactotransferrin LTF 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
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