DT-Web

DB01033 - Mercaptopurine


Identification
Name Mercaptopurine
Accession Number DB01033 (APRD01096)
Type small molecule
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 152.177
Groups approved
Monoisotopic Weight 152.015666838
Pharmacology
Indication For remission induction and maintenance therapy of acute lymphatic leukemia.
Mechanism of action Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to thioinosinic acid (TIMP). This intracellular nucleotide inhibits several reactions involving inosinic acid (IMP), including the conversion of IMP to xanthylic acid (XMP) and the conversion of IMP to adenylic acid (AMP) via adenylosuccinate (SAMP). In addition, 6-methylthioinosinate (MTIMP) is formed by the methylation of TIMP. Both TIMP and MTIMP have been reported to inhibit glutamine-5-phosphoribosylpyrophosphate amidotransferase, the first enzyme unique to the de novo pathway for purine ribonucleotide synthesis. Experiments indicate that radiolabeled mercaptopurine may be recovered from the DNA in the form of deoxythioguanosine. Some mercaptopurine is converted to nucleotide derivatives of 6-thioguanine (6-TG) by the sequential actions of inosinate (IMP) dehydrogenase and xanthylate (XMP) aminase, converting TIMP to thioguanylic acid (TGMP).
Absorption Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Protein binding Plasma protein binding averages 19% over the concentration range 10 to 50 µg/mL (a concentration only achieved by intravenous administration of mercaptopurine at doses exceeding 5 to 10 mg/kg).
Biotransformation Hepatic. Degradation primarily by xanthine oxidase. The catabolism of mercaptopurine and its metabolites is complex. In humans, after oral administration of 35S-6-mercaptopurine, urine contains intact mercaptopurine, thiouric acid (formed by direct oxidation by xanthine oxidase, probably via 6-mercapto-8-hydroxypurine), and a number of 6-methylated thiopurines. The methylthiopurines yield appreciable amounts of inorganic sulfate.
Route of elimination Not Available
Toxicity Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Mercaptopurine may decrease the anticoagulant effect of acenocoumarol.
Allopurinol Allopurinol may increase the effect of thiopurine, mercaptopurine.
Aminosalicylic Acid Aminosalicylic acid may increase the toxicity of thiopurine, mercaptopurine.
Anisindione Mercaptopurine may decrease the anticoagulant effect of anisindione.
Atracurium The agent dereases the effect of the muscle relaxant
Dicumarol Mercaptopurine may decrease the anticoagulant effect of dicumarol.
Doxacurium chloride The agent dereases the effect of the muscle relaxant
Febuxostat Coadministration of febuxostat with xanthine oxidase substrate drugs (azathioprine, mercaptopurine or theophylline) could increase plasma concentrations of these drugs, since these drugs are metabolized by xanthine oxidase, resulting in severe toxicity; hence their concomitant use is contraindicated. Since febuxostat does not inhibit or induce cytochrome P450 enzymes it lacks significant drug interactions with other drugs metabolized of these enzymes.
Mesalazine Mesalazine may increase the toxicity of thiopurine, mercaptopurine.
Metocurine The agent dereases the effect of the muscle relaxant
Mivacurium The agent dereases the effect of the muscle relaxant
Olsalazine Olsalazine may increase the toxicity of thiopurine, mercaptopurine.
Pancuronium The agent dereases the effect of the muscle relaxant
Sulfasalazine Sulfasalazine may increase the toxicity of thiopurine, mercaptopurine.
Thioguanine Complete cross resistance may occur.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Tubocurarine The agent dereases the effect of the muscle relaxant
Vecuronium The agent dereases the effect of the muscle relaxant
Warfarin Mercaptopurine may decrease the anticoagulant effect of warfarin.
Food Interactions
  • Preferably on an empty stomach, drink plenty of liquids, avoid alcohol.

Targets


Hypoxanthine-guanine phosphoribosyltransferase
Name Hypoxanthine-guanine phosphoribosyltransferase
Gene Name HPRT1
Pharmacological action yes
Actions inhibitor
References
  • Dubinsky MC: Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731-43. - Pubmed
DTHybrid score 0.8589

Enzymes


Thiopurine S-methyltransferase
Name Thiopurine S-methyltransferase
Gene Name TPMT
Actions substrate
References
  • Dubinsky MC: Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731-43. - Pubmed
DTHybrid score 0.4169
Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions substrate
References
  • Dubinsky MC: Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731-43. - Pubmed
DTHybrid score 0.5612
Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA2040 -
DTHybrid score 0.3392

Transporters


Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed
  • Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed
  • Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score 0.3053
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Chen ZS, Lee K, Kruh GD: Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem. 2001 Sep 7;276(36):33747-54. Epub 2001 Jul 10. - Pubmed
DTHybrid score 0.3362
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions substrate
References
  • Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P: Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81. - Pubmed
DTHybrid score 0.225
Sodium/nucleoside cotransporter 2
Name Sodium/nucleoside cotransporter 2
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA2040 -
DTHybrid score Not Available
Solute carrier family 28 member 3
Name Solute carrier family 28 member 3
Gene Name SLC28A3
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA2040 -
DTHybrid score 0.3514
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA2040 -
DTHybrid score 0.4217
Equilibrative nucleoside transporter 2
Name Equilibrative nucleoside transporter 2
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA2040 -
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
1729 Solute carrier family 22 member 6 SLC22A6 0.1522
4773 Deoxycytidine kinase DCK 0.1485
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.1185
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.1165
6143 Solute carrier family 22 member 7 SLC22A7 0.1153
1253 Interferon gamma IFNG 0.1133
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.1054
4512 Cytochrome P450 3A4 CYP3A4 0.103
1024 Solute carrier family 22 member 11 SLC22A11 0.0924
603 DNA polymerase alpha catalytic subunit POLA1 0.09
896 Glutathione S-transferase Mu 1 GSTM1 0.0714
1588 Multidrug resistance protein 1 ABCB1 0.0702
6021 Adenosine kinase ADK 0.069
4757 Cytochrome P450 2C9 CYP2C9 0.0661
24 Thymidylate synthase TMP1 0.0658
359 Thymidylate synthase TYMS 0.0658
2626 Thymidylate synthase thyA 0.0658
2729 Thymidylate synthase thyA 0.0658
5352 Thymidylate synthase THYA 0.0658
4031 Glutathione S-transferase A1 GSTA1 0.0653
3932 Glutathione S-transferase A2 GSTA2 0.0644
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0633
6148 Multidrug resistance-associated protein 7 ABCC10 0.0633
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0618
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0576
752 Large structural protein L 0.0576
587 Serum albumin ALB 0.0574
6145 Solute carrier family 22 member 1 SLC22A1 0.0549
4924 Cytochrome P450 2C8 CYP2C8 0.0535
592 Carbonic anhydrase 4 CA4 0.0535
3611 Cytidine deaminase cdd 0.0527
3707 Cytidine deaminase cdd 0.0527
4211 Cytidine deaminase CDA 0.0527
4200 Cytochrome P450 1A2 CYP1A2 0.0504
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0499
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0498
295 Carbonic anhydrase 1 CA1 0.0496
6144 Solute carrier family 22 member 2 SLC22A2 0.0476
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0471
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0462
290 Prostaglandin G/H synthase 2 PTGS2 0.0457
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0447
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0438
4271 Anthranilate phosphoribosyltransferase trpD 0.0437
277 Purine nucleoside phosphorylase PNP 0.0437
2870 Purine nucleoside phosphorylase punA 0.0437
2945 Purine nucleoside phosphorylase punA 0.0437
4659 Purine nucleoside phosphorylase TM_1596 0.0437
4825 Purine nucleoside phosphorylase TTHA1435 0.0437
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0427
2794 Orotate phosphoribosyltransferase pyrE 0.0423
862 Multidrug resistance-associated protein 1 ABCC1 0.0418
1757 Myeloperoxidase MPO 0.0409
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0395
4118 Cytochrome P450 3A5 CYP3A5 0.0388
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0388
702 UMP-CMP kinase CMPK1 0.0384
357 Carbonic anhydrase 2 CA2 0.0383
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0382
723 Cytosolic phospholipase A2 PLA2G4A 0.0378
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0366
128 Adenine phosphoribosyltransferase APRT 0.0353
3957 Adenosine deaminase ADA 0.0353
338 DNA polymerase UL30 0.0346
379 DNA polymerase UL54 0.0346
697 DNA polymerase ORF28 0.0346
2482 DNA polymerase 43 0.0346
4104 DNA polymerase BALF5 0.0346
2353 Apolipoprotein(a) LPA 0.0343
5294 Nucleoside diphosphate kinase A NME1 0.0343
390 Adenosine A3 receptor ADORA3 0.0339
6107 Cytochrome P450 3A7 CYP3A7 0.0332
5626 Nucleoside diphosphate kinase B NME2 0.0325
268 Adenosine A2b receptor ADORA2B 0.0323
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0322
6016 Cytochrome P450 2C19 CYP2C19 0.0322
6030 Cytochrome P450 2B6 CYP2B6 0.0312
558 Solute carrier family 12 member 1 SLC12A1 0.0309
466 Solute carrier family 12 member 3 SLC12A3 0.0306
234 Plasminogen PLG 0.0306
1198 Serum paraoxonase/arylesterase 1 PON1 0.0303
6223 Penicillin-binding protein 1C pbpC 0.0303
1792 Tissue-type plasminogen activator PLAT 0.0297
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0296
1898 Cytochrome P450 1B1 CYP1B1 0.029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0286
20 Prostaglandin G/H synthase 1 PTGS1 0.0282
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0282
3811 Cytochrome P450 19A1 CYP19A1 0.0279
3917 Methylenetetrahydrofolate reductase MTHFR 0.0277
6137 Multidrug resistance-associated protein 6 ABCC6 0.0275
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0274
342 P protein [Includes: DNA-directed DNA polymerase P 0.0272
612 P protein [Includes: DNA-directed DNA polymerase P 0.0272
4119 Cytochrome P450 2D6 CYP2D6 0.027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0253
776 Bile salt export pump ABCB11 0.025
118 Organic cation/carnitine transporter 2 SLC22A5 0.0246
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0243
543 Penicillin-binding protein 1B mrcB 0.0242
6186 Penicillin-binding protein 1B ponB 0.0242
6822 Penicillin-binding protein 1b pbp1b 0.0242
6844 Penicillin-binding protein 1b pbp1b 0.0242
6013 Cytochrome P450 2E1 CYP2E1 0.0242
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0239
645 Penicillin-binding protein 1A mrcA 0.0238
5805 Penicillin-binding protein 1A ponA 0.0238
6185 Penicillin-binding protein 1A mrcA 0.0238
6799 Penicillin-binding protein 1A pbpA 0.0238
16 Adenosine A1 receptor ADORA1 0.0236
1178 Adenosine A2a receptor ADORA2A 0.0236
2251 Thymidylate kinase tmk 0.023
2254 Thymidylate kinase DTYMK 0.023
3522 Thymidylate kinase tmk 0.023
3685 Catabolite gene activator crp 0.0229
4655 Adenylate cyclase cyaC 0.0229
4759 Adenylate cyclase cyaB2 0.0229
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0225
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0225
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0225
6024 Cytochrome P450 1A1 CYP1A1 0.0222
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0217
6111 DNA polymerase epsilon subunit 4 POLE4 0.0217
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0217
6110 DNA polymerase epsilon subunit 2 POLE2 0.0216
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0216
2257 Uridine phosphorylase udp 0.0215
5132 Uridine phosphorylase udp 0.0215
6141 Sodium/bile acid cotransporter SLC10A1 0.0215
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0213
6147 Solute carrier family 22 member 3 SLC22A3 0.0211
5718 Cytochrome P450 2A6 CYP2A6 0.0203
115 Penicillin-binding protein 2 mrdA 0.0203
6069 Penicillin-binding protein 2 mrdA 0.0203
6118 Penicillin-binding protein 2 penA 0.0203
6187 Penicillin-binding protein 2 pbpA 0.0203
6686 Penicillin-binding protein 2 pbp2 0.0203
6939 Penicillin-binding protein 2 mrdA 0.0203
7163 Penicillin-binding protein 2 pbpA 0.0203
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.02
833 Organic cation/carnitine transporter 1 SLC22A4 0.0199
4226 Uridine phosphorylase 2 UPP2 0.0197
4760 Mll3241 protein mll3241 0.0195
365 Dihydrofolate reductase DHFR 0.0192
2381 Dihydrofolate reductase DFR1 0.0192
2833 Dihydrofolate reductase Not Available 0.0192
2931 Dihydrofolate reductase folA 0.0192
3544 Dihydrofolate reductase folA 0.0192
3682 Dihydrofolate reductase folA 0.0192
6642 Dihydrofolate reductase folA 0.0192
6756 Dihydrofolate reductase dfrA 0.0192
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0189
1 Peptidoglycan synthetase ftsI ftsI 0.0189
4155 Peptidoglycan synthetase ftsI ftsI 0.0189
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0188
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0184
738 Monocarboxylate transporter 1 SLC16A1 0.0179
4225 Uridine phosphorylase 1 UPP1 0.0176
378 Alpha-2C adrenergic receptor ADRA2C 0.0176
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0176
1830 5'-nucleotidase NT5E 0.0176
629 Alpha-2B adrenergic receptor ADRA2B 0.0173
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0171
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0166
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
413 Amidophosphoribosyltransferase PPAT 0.0165
2515 Amidophosphoribosyltransferase purF 0.0165
3714 Amidophosphoribosyltransferase purF 0.0165
125 DNA polymerase beta POLB 0.0163
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0156
327 Glutathione reductase gor 0.0156
5110 Glutathione reductase GR2 0.0156
4604 Liver carboxylesterase 1 CES1 0.0155
318 Alpha-2A adrenergic receptor ADRA2A 0.0154
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0153
3823 Cytokine receptor common gamma chain IL2RG 0.0151
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2757 Inorganic pyrophosphatase ppa 0.0146
6238 Inorganic pyrophosphatase ppa 0.0146
6968 Inorganic pyrophosphatase PPA1 0.0146
3639 Thymidine phosphorylase deoA 0.0142
3936 Thymidine phosphorylase TYMP 0.0142
6085 Fatty acid-binding protein, intestinal FABP2 0.0141
908 Glutathione S-transferase theta-1 GSTT1 0.0141
6167 Organic solute transporter subunit beta OSTB 0.0141
6166 Organic solute transporter subunit alpha OSTA 0.0141
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0138
811 Translocator protein TSPO 0.0137
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0137
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0136
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0135
6031 Cytochrome P450 3A43 CYP3A43 0.0135
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0134
724 Interleukin-2 receptor alpha chain IL2RA 0.0131
717 Interleukin-2 receptor subunit beta IL2RB 0.0131
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.013
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.013
400 Coagulation factor IX F9 0.0129
5461 Coagulation factor IX F9 0.0129
1141 Sialidase-1 NEU1 0.0129
64 Neuraminidase NA 0.0129
641 Neuraminidase NA 0.0129
2676 Neuraminidase NA 0.0129
3026 Neuraminidase NA 0.0129
3519 Neuraminidase NA 0.0129
6007 Neuraminidase NA 0.0129
2647 RNA-directed RNA polymerase P2 0.0128
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0125
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0125
6163 Copper-transporting ATPase 2 ATP7B 0.0124
6165 Copper-transporting ATPase 1 ATP7A 0.0124
4217 Telomerase reverse transcriptase TERT 0.0123
136 Estrogen receptor ESR1 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0119
604 Vitamin K-dependent protein Z PROZ 0.0119
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0119
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0119
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0119
6146 High affinity copper uptake protein 1 SLC31A1 0.0118
6149 Solute carrier family 22 member 10 SLC22A10 0.0116
3010 Regulatory protein blaR1 blaR1 0.0116
2149 Angiogenin ANG 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0115
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0115
293 Gamma-glutamyl hydrolase GGH 0.0113
904 Glutathione S-transferase P GSTP1 0.0112
2727 S-adenosylmethionine synthetase metK 0.0112
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.011
869 Estrogen receptor beta ESR2 0.0109
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
4600 Malonamidase E2 Not Available 0.0109
422 Vitamin K-dependent protein C PROC 0.0108
1245 Vitamin K-dependent protein S PROS1 0.0108
1656 CYP2B protein CYP2B 0.0108
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0107
3923 Cholinesterase BCHE 0.0107
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0107
2717 Folylpolyglutamate synthase fgs 0.0107
6168 Solute carrier family 22 member 16 SLC22A16 0.0106
159 Penicillin-binding protein 2B penA 0.0102
6121 Penicillin-binding protein 2B penA 0.0102
5482 Sialidase-2 NEU2 0.0101
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0101
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
123 Diamine acetyltransferase 1 SAT1 0.01
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0099
1650 Heme carrier protein 1 SLC46A1 0.0099
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0098
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0096
6395 Myosin-14 MYH14 0.0096
468 Cytochrome P450 4A11 CYP4A11 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2320 Thymidine kinase, cytosolic TK1 0.0093
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0092
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0092
6859 Protein S100-A4 S100A4 0.0091
798 Osteocalcin BGLAP 0.0088
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0087
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0087
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0086
124 Histamine H2 receptor HRH2 0.0086
6218 Pannexin-1 PANX1 0.0081
5818 Folate receptor alpha FOLR1 0.008
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.008
369 Coagulation factor VII F7 0.0079
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0078
6033 High affinity interleukin-8 receptor A CXCR1 0.0078
449 Ornithine decarboxylase ODC1 0.0078
551 Carnitine O-acetyltransferase CRAT 0.0075
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0075
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0075
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0074
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0072
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0072
1648 Elastin ELN 0.0072
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
438 Taste receptor type 1 member 2 TAS1R2 0.0071
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0067
267 Plasminogen activator inhibitor 1 SERPINE1 0.0067
952 Dipeptidyl peptidase 4 DPP4 0.0066
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
3809 Estrogen-related receptor gamma ESRRG 0.0065
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0064
4120 NADPH--cytochrome P450 reductase POR 0.0061
465 Calmodulin CALM1 0.006
183 Vascular endothelial growth factor A VEGFA 0.006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.006
6220 Aryl hydrocarbon receptor AHR 0.006
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
239 Coagulation factor X F10 0.0059
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
556 Alpha-1A adrenergic receptor ADRA1A 0.0059
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0058
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0057
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0055
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0054
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
3587 Gastrotropin FABP6 0.0053
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0051
489 Monocarboxylate transporter 2 SLC16A7 0.0051
1374 Natriuretic peptides B NPPB 0.0051
1827 Gap junction alpha-1 protein GJA1 0.0051
1908 Vascular cell adhesion protein 1 VCAM1 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
1313 Lactoylglutathione lyase GLO1 0.0051
33 Cystine/glutamate transporter SLC7A11 0.005
165 FL cytokine receptor FLT3 0.005
718 Folate receptor gamma FOLR3 0.005
299 Folate receptor beta FOLR2 0.005
804 Mitochondrial folate transporter/carrier SLC25A32 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
54 Prothrombin F2 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
32 Vascular endothelial growth factor receptor 1 FLT1 0.0048
817 DNA topoisomerase 2-alpha TOP2A 0.0047
633 Penicillin-binding proteins 1A/1B pbpA 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
228 Beta platelet-derived growth factor receptor PDGFRB 0.0046
6128 Carbonic anhydrase-related protein 10 CA10 0.0044
6133 Sodium channel subunit beta-2 SCN2B 0.0044
6134 Sodium channel subunit beta-3 SCN3B 0.0044
6132 Sodium channel subunit beta-1 SCN1B 0.0044
6135 Sodium channel subunit beta-4 SCN4B 0.0044
6129 Carbonic anhydrase-related protein 11 CA11 0.0044
6127 Carbonic anhydrase-related protein CA8 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0043
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0043
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0043
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0043
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
756 Sex hormone-binding globulin SHBG 0.0042
504 Mast/stem cell growth factor receptor KIT 0.0042
2021 Thrombomodulin THBD 0.0042
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0042
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0041
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
4034 Glutaredoxin-1 GLRX 0.004
4043 Glutaredoxin-2, mitochondrial GLRX2 0.004
4037 Hypothetical protein GPX1 0.004
4297 Hypothetical protein SP_1951 0.004
4521 Hypothetical protein BC_2969 0.004
4540 Hypothetical protein TM_1070 0.004
4555 Hypothetical protein MT1739 0.004
4569 Hypothetical protein mshD 0.004
4578 Hypothetical protein PA3270 0.004
4747 Hypothetical protein PA3967 0.004
5177 Hypothetical protein TM_0096 0.004
5194 Hypothetical protein PA1204 0.004
5240 Hypothetical protein Rv2991 0.004
5370 Hypothetical protein TM_1158 0.004
5710 Hypothetical protein Tb927.5.1360 0.004
1928 Leukotriene C4 synthase LTC4S 0.004
4029 Microsomal glutathione S-transferase 3 MGST3 0.004
4032 Microsomal glutathione S-transferase 1 MGST1 0.004
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.004
4035 Glutathione S-transferase Mu 5 GSTM5 0.004
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.004
4040 Glutathione peroxidase 7 GPX7 0.004
910 Epididymal secretory glutathione peroxidase GPX5 0.004
4036 Glutathione peroxidase 6 GPX6 0.004
903 Glutathione S-transferase A5 GSTA5 0.004
911 Glutathione peroxidase 3 GPX3 0.004
906 Glutathione peroxidase 1 GPX1 0.004
900 Glutathione S-transferase A4 GSTA4 0.004
4038 Glutathione peroxidase 4 GPX4 0.004
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.004
4042 Glutathione transferase omega-2 GSTO2 0.004
907 Glutathione peroxidase 2 GPX2 0.004
4033 S-formylglutathione hydrolase ESD 0.004
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.004
1867 Major prion protein PRNP 0.0039
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0039
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0039
4192 DNA topoisomerase 2-beta TOP2B 0.0039
831 D(2) dopamine receptor DRD2 0.0039
407 Vascular endothelial growth factor receptor 2 KDR 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0038
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0038
6130 Carbonic anhydrase 13 CA13 0.0038
373 Transthyretin TTR 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0037
6131 Carbonic anhydrase 14 CA14 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
275 Arachidonate 5-lipoxygenase ALOX5 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0036
5773 DNA-directed RNA polymerase beta chain rpoB 0.0036
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0036
130 Prostacyclin synthase PTGIS 0.0036
3319 Hydroxyacylglutathione hydrolase HAGH 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
897 Glutathione S-transferase kappa 1 GSTK1 0.0035
898 Glutathione S-transferase A3 GSTA3 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
909 Maleylacetoacetate isomerase GSTZ1 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6122 Carbonic anhydrase 3 CA3 0.0034
899 Glutathione S-transferase Mu 3 GSTM3 0.0034
905 Glutathione transferase omega-1 GSTO1 0.0034
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0034
6209 30S ribosomal protein S19 rpsS 0.0034
6712 30S ribosomal protein S19 rpsS 0.0034
6726 30S ribosomal protein S19 rpsS 0.0034
6207 30S ribosomal protein S14 rpsN 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
4041 Microsomal glutathione S-transferase 2 MGST2 0.0034
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
6106 Cytochrome P450 2C18 CYP2C18 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
2165 Glutathione S-transferase Mu 2 GSTM2 0.0031
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0031
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0031
3007 Carbonic anhydrase 12 CA12 0.0031
4205 Carbonic anhydrase 9 CA9 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.0031
207 Glutathione synthetase GSS 0.0031
5269 Glutathione synthetase gshB 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.003
950 Alpha platelet-derived growth factor receptor PDGFRA 0.003
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.003
6126 Carbonic anhydrase 7 CA7 0.0029
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0029
527 Prostacyclin receptor PTGIR 0.0029
901 Glutathione S-transferase Mu 4 GSTM4 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0028
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
146 Androgen receptor AR 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0028
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
5126 Arginase rocF 0.0027
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
1654 Interleukin-1 beta IL1B 0.0026
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0026
3939 Amine oxidase [flavin-containing] B MAOB 0.0026
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0026
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0026
76 Nitric-oxide synthase, brain NOS1 0.0026
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0025
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0025
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
244 Angiotensin-converting enzyme ACE 0.0025
517 Alcohol dehydrogenase 1C ADH1C 0.0025
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
663 Solute carrier family 12 member 4 SLC12A4 0.0024
53 Solute carrier family 12 member 5 SLC12A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
766 Beta-2 adrenergic receptor ADRB2 0.0024
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
310 Solute carrier family 12 member 2 SLC12A2 0.0023
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
6645 D-amino-acid oxidase DAO 0.0022
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0022
3810 Catechol O-methyltransferase COMT 0.0022
494 Caspase-1 CASP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6501 Fatty acid-binding protein, liver FABP1 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
1507 Cytochrome c CYCS 0.0021
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
3760 Penicillin-binding protein 5 precursor dacA 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0018
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0018
6500 Phospholipase A2 PLA2G1B 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
7 Nitric oxide synthase, inducible NOS2 0.0017
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0017
816 Biliverdin reductase A BLVRA 0.0017
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0017
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0017
819 Penicillin-binding protein 4 dacB 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0016
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0016
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0016
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0016
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0016
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0016
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0016
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0016
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0016
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0016
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0016
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0016
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0016
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0016
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0016
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0016
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0016
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0016
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0016
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0016
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0016
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0016
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0016
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0016
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0016
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0016
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0016
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0016
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0016
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0016
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0016
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0016
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0016
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0016
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0016
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0016
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0016
644 Heme oxygenase 2 HMOX2 0.0016
4982 Heme oxygenase 2 pbsA2 0.0016
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0016
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0016
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0016
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0016
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0016
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0016
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0016
729 GDP-L-fucose synthetase TSTA3 0.0016
3463 GDP-L-fucose synthetase fcl 0.0016
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0016
167 L-lactate dehydrogenase C chain LDHC 0.0016
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0016
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0016
206 3-keto-steroid reductase HSD17B7 0.0016
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0016
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0016
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0016
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0016
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0016
107 C-4 methylsterol oxidase SC4MOL 0.0016
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0016
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0016
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0016
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0016
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0016
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0016
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0016
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0016
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0016
3726 D-3-phosphoglycerate dehydrogenase serA 0.0016
4291 D-3-phosphoglycerate dehydrogenase serA 0.0016
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0016
34 7-dehydrocholesterol reductase DHCR7 0.0016
711 UDP-glucose 6-dehydrogenase UGDH 0.0016
3672 UDP-glucose 6-dehydrogenase hasB 0.0016
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0016
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0016
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0016
643 Peroxisomal bifunctional enzyme EHHADH 0.0016
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0016
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0016
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0016
646 Malate dehydrogenase, cytoplasmic MDH1 0.0015
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0015
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0015
328 Sorbitol dehydrogenase SORD 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0015
597 Dihydropteridine reductase QDPR 0.0015
396 Alcohol dehydrogenase 4 ADH4 0.0015
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0014
666 NADP-dependent malic enzyme ME1 0.0014
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0014
857 Malate dehydrogenase, mitochondrial MDH2 0.0014
6026 Alcohol dehydrogenase 6 ADH6 0.0014
77 L-lactate dehydrogenase B chain LDHB 0.0014
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0014
12 Alcohol dehydrogenase class 3 ADH5 0.0014
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0013
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0013
626 Cysteine dioxygenase type 1 CDO1 0.0013
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
627 11-cis retinol dehydrogenase RDH5 0.0013
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0013
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0013
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0013
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
473 L-lactate dehydrogenase A chain LDHA 0.0013
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0013
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0013
4486 Phenol 2-hydroxylase component B pheA2 0.0013
4439 Ferredoxin reductase bphA4 0.0013
4477 Dihydrolipoyl dehydrogenase lpdV 0.0013
5077 Dihydrolipoyl dehydrogenase Not Available 0.0013
5117 Dihydrolipoyl dehydrogenase lpd 0.0013
13 Aminomethyltransferase, mitochondrial AMT 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
5078 Amine oxidase, flavin-containing PSPTO1126 0.0012
5122 Mersacidin decarboxylase mrsD 0.0012
526 Thioredoxin reductase trxB 0.0012
3767 Thioredoxin reductase trxB 0.0012
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0012
3763 5,10-methylenetetrahydrofolate reductase metF 0.0012
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0012
5094 5,10-methylenetetrahydrofolate reductase metF 0.0012
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0012
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0012
5115 FkbI fkbI 0.0012
3133 UDP-galactopyranose mutase glf 0.0012
5099 UDP-galactopyranose mutase glf 0.0012
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0012
5095 Putidaredoxin reductase camA 0.0012
5083 Cryptochrome DASH cry 0.0012
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0012
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5081 L-aspartate oxidase nadB 0.0012
5111 Phenylacetone monooxygenase pamO 0.0012
5109 Outer membrane protein p64k or PM-6 m-6 0.0012
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0012
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0012
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0012
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0012
251 Alcohol dehydrogenase 1A ADH1A 0.0012
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
279 Tyrosinase TYR 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
4440 NADH peroxidase npr 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
654 Flavin reductase BLVRB 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0011
5072 N,N-dimethylglycine oxidase dmg 0.0011
5073 Ferredoxin--NADP reductase petH 0.0011
5076 Ferredoxin--NADP reductase fpr 0.0011
5119 Ferredoxin--NADP reductase petH 0.0011
5121 Ferredoxin--NADP reductase fpr 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0011
3594 Deoxyribodipyrimidine photo-lyase phr 0.0011
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0011
5080 Deoxyribodipyrimidine photo-lyase phr 0.0011
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0011
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0011
2526 NADPH-ferredoxin reductase fprA fprA 0.0011
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0011
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0011
810 Heme oxygenase 1 HMOX1 0.0011
3391 Heme oxygenase 1 pbsA1 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
2470 Pyruvate oxidase pox5 0.0011
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0011
444 Alcohol dehydrogenase 1B ADH1B 0.0011
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.001
2268 Cholesterol oxidase choB 0.001
2822 Cholesterol oxidase choA 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
6014 Cytochrome P450 2A13 CYP2A13 0.001
380 Cytochrome P450 17A1 CYP17A1 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
126 D-lactate dehydrogenase dld 0.001
3545 D-lactate dehydrogenase Not Available 0.001
4510 D-lactate dehydrogenase ldhA 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.001
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.001
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.001
2893 Glycine oxidase thiO 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0009
2567 Thymidylate synthase thyX thyX 0.0009
2823 Trypanothione reductase TPR 0.0009
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
2769 P-hydroxybenzoate hydroxylase pobA 0.0009
2809 P-hydroxybenzoate hydroxylase pobA 0.0009
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0009
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0009
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0009
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0009
2380 Monomeric sarcosine oxidase soxA 0.0008
822 Aldose reductase AKR1B1 0.0008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0008
824 Sodium-dependent serotonin transporter SLC6A4 0.0007
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