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NH(3)-dependent NAD(+) synthetase


Partner ID 2910
Name NH(3)-dependent NAD(+) synthetase
Synonyms 4915
Gene name nadE
General function Coenzyme transport and metabolism
Specific function Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction
Gene sequence + ...

ATGAGCATGCAGGAAAAGATTATGCGTGAGTTACATGTGAAGCCCTCAATTGATCCAAAGCAAGAAATTGAGGACCGAGTCAATTTTTTAAAACAATATGTAAAGAAAACCGGTGCTAAAGGCTTTGTATTGGGAATCAGCGGGGGCCAGGATTCAACACTTGCGGGAAGACTCGCTCAGCTTGCGGTGGAGAGCATTCGCGAGGAGGGCGGAGACGCTCAATTTATCGCGGTCCGTCTTCCGCATGGCACACAGCAGGATGAAGACGATGCCCAGCTTGCTTTGAAGTTTATTAAGCCGGATAAATCATGGAAGTTTGATATTAAATCGACAGTCAGCGCTTTTTCTGATCAGTATCAGCAGGAAACAGGCGATCAGCTGACGGACTTTAATAAAGGAAACGTAAAAGCAAGAACAAGAATGATCGCGCAATACGCGATCGGCGGCCAGGAAGGTCTTCTTGTGTTAGGAACAGACCATGCTGCTGAAGCAGTGACTGGTTTCTTTACGAAGTACGGTGACGGCGGAGCAGACCTCCTGCCGCTGACAGGCTTGACGAAGCGCCAGGGAAGAACCTTGCTGAAAGAGCTGGGTGCACCGGAACGCTTATACTTAAAAGAACCGACTGCCGATCTGCTCGACGAAAAACCGCAGCAGTCGGATGAAACAGAGCTTGGCATTTCCTACGACGAGATTGACGATTATCTCGAAGGAAAAGAAGTATCAGCGAAAGTATCAGAAGCGCTGGAAAAACGCTACAGCATGACTGAACATAAACGCCAGGTTCCGGCGTCTATGTTTGATGACTGGTGGAAATAA
Protein sequence + ...

MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
GO Classification
function
ATP binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
binding
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
nucleotide binding
catalytic activity
NAD+ synthase (glutamine-hydrolyzing) activity
purine nucleotide binding
adenyl nucleotide binding
process
cofactor metabolism
coenzyme metabolism
coenzyme biosynthesis
physiological process
pyridine nucleotide biosynthesis
NAD biosynthesis
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01907 Nicotinamide-Adenine-Dinucleotide
DB02212 Pyrophosphate 2-
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB04099 Deamido-Nad+

Associated as Prediction

Id Name
DB00142 L-Glutamic Acid
DB00143 Glutathione
DB00157 NADH
DB00162 Vitamin A
DB00262 Carmustine
DB00300 Tenofovir
DB00336 Nitrofurazone
DB00352 Thioguanine
DB00435 Nitric Oxide
DB00536 Guanidine
DB00563 Methotrexate
DB00609 Ethionamide
DB00688 Mycophenolate mofetil
DB00695 Furosemide
DB00709 Lamivudine
DB00718 Adefovir Dipivoxil
DB00727 Nitroglycerin
DB00742 Mannitol
DB00755 Tretinoin
DB00756 Hexachlorophene
DB00789 Gadopentetate dimeglumine
DB00814 Meloxicam
DB00822 Disulfiram
DB00851 Dacarbazine
DB00867 Ritodrine
DB00898 Ethanol
DB00920 Ketotifen
DB00951 Isoniazid
DB00993 Azathioprine
DB00997 Doxorubicin
DB01024 Mycophenolic acid
DB01033 Mercaptopurine
DB01213 Fomepizole
DB01536 4-Androstenedione
DB01561 Androstanedione
DB01612 Amyl Nitrite
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01643 Thymidine-5'-Phosphate
DB01644 3,6-Dihydroxy-Xanthene-9-Propionic Acid
DB01677 Fumarate
DB01691 Indole Naphthyridinone
DB01693 Ribavirin Monophosphate
DB01694 D-tartaric acid
DB01708 Dehydroepiandrosterone
DB01711 2,3,4,5,6-Pentafluorobenzyl Alcohol
DB01713 Udp-Alpha-D-Xylopyranose
DB01727 Isocitric Acid
DB01752 S-Adenosyl-L-Homocysteine
DB01769 Double Oxidized Cysteine
DB01788 4-Imino-5-Methidyl-2-Methylpyrimidine
DB01792 Adenylyl-3'-5'-Phospho-Uridine-3'-Monophosphate
DB01799 4-Hydroxy-3-Methyl Butyl Diphosphate
DB01814 2-Tridecanoyloxy-Pentadecanoic Acid
DB01848 Isocitrate Calcium Complex
DB01854 5-Bromonicotinamide
DB01861 Glucose-Uridine-C1,5'-Diphosphate
DB01865 3-(6-Aminopyridin-3-Yl)-N-Methyl-N-[(1-Methyl-1h-Indol-2-Yl)Methyl]Acrylamide
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01930 2,4-Dihydroxy-3,3-Dimethyl-Butyrate
DB01942 Formic Acid
DB01944 (S)-blebbistatin
DB01971 trans-urocanic acid
DB01972 Guanosine-5'-Monophosphate
DB01992 Coenzyme A
DB02007 Alpha-D-Glucose-6-Phosphate
DB02059 Adenosine-5-Diphosphoribose
DB02075 (1s)-1(9-Deazahypoxanthin-9yl)1,4-Dideoxy-1,4-Imino-D-Ribitol-5-Phosphate
DB02076 6-Phosphogluconic Acid
DB02111 3-Hydroxyisoxazole-4-Carboxylic Acid
DB02115 Daidzin
DB02119 6-Hydroxymethyl-7,8-Dihydropterin
DB02123 Glycochenodeoxycholic Acid
DB02131 N-1-Methylheptylformamide
DB02147 Cyclo-Tetrametavanadate
DB02153 3-Sulfinoalanine
DB02175 Malonic acid
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB02187 Equilin
DB02190 2-Oxalosuccinic Acid
DB02196 Uridine-Diphosphate-N-Acetylgalactosamine
DB02205 6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One
DB02212 Pyrophosphate 2-
DB02234 Ethylisothiourea
DB02249 2-Ethoxyethanol
DB02254 Trifluoro-thiamin phosphate
DB02263 Glyceraldehyde-3-Phosphate
DB02270 Dimethylallyl S-Thiolodiphosphate
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
DB02323 EM-1745
DB02329 Carbenoxolone
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02345 Selenocysteine
DB02355 Adenosine-5'-Rp-Alpha-Thio-Triphosphate
DB02379 Beta-D-Glucose
DB02383 Tolrestat
DB02401 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid
DB02415 N-Octyl-2-Hydroxyethyl Sulfoxide
DB02421 Uridine-5'-Diphosphate-Mannose
DB02452 Thymidine-5'-Triphosphate
DB02475 Deoxyguanidinoproclavaminic acid
DB02480 (S)-4-Bromo-3-Hydroxy-3-Methylbutyl Diphosphate
DB02481 N-Benzylformamide
DB02483 Etheno-Nad
DB02508 Isopentyl Pyrophosphate
DB02553 Glutathionylspermidine Disulfide
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
DB02592 Carbaphosphonate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB02607 Adenosine Phosphonoacetic Acid
DB02613 Decylamine-N,N-Dimethyl-N-Oxide
DB02621 Latrunculin A
DB02626 Phenylferricrocin-Iron
DB02637 Oxaloacetate Ion
DB02649 3-Amino-3-Oxopropanoic Acid
DB02659 Cholic Acid
DB02694 Pantoyl Adenylate
DB02700 3-Deoxy-D-Glucosamine
DB02701 Nicotinamide
DB02721 4-Iodopyrazole
DB02724 Delta-2-Albomycin A1
DB02757 Pyrazole
DB02767 3-Hydroxy-Myristic Acid
DB02772 Sucrose
DB02790 Phenyl-Uridine-5'-Diphosphate
DB02820 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
DB02822 Para-Bromobenzyl Alcohol
DB02854 Aetiocholanolone
DB02865 Glucosamine 4-Phosphate
DB02871 3-Butylthiolane 1-Oxide
DB02885 4-Imino-5-Methidyl-2-Trifluoromethylpyrimidine
DB02887 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol
DB02901 Dihydrotestosterone
DB02907 2-Amino-Vinyl-Phosphate
DB02937 Gamma-Arsono-Beta, Gamma-Methyleneadenosine-5'-Diphosphate
DB02954 (Carboxyhydroxyamino)Ethanoic Acid
DB02968 Penicillin G Acyl-Serine
DB02990 C16-Fatty-Acyl-Substrate-Mimic
DB03014 Heme
DB03020 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
DB03030 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole
DB03041 Udp-Glucuronic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03061 (R)-N-(1-Methyl-Hexyl)-Formamide
DB03070 Selenazole-4-Carboxyamide-Adenine Dinucleotide
DB03075 (Diphosphono)Aminophosphonic Acid
DB03088 Pyroglutamic Acid
DB03095 Tetramethylammonium Ion
DB03103 Thymidine-5'- Diphosphate
DB03107 Beta-Alanine
DB03111 Glucosamine 1-Phosphate
DB03126 Mant-Adp
DB03145 4-Methyl-5-Hydroxyethylthiazole Phosphate
DB03147 Flavin-Adenine Dinucleotide
DB03153 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol
DB03161 Thymidine-5'-Diphospho-Beta-D-Xylose
DB03162 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid
DB03165 2-Dimethylamino-Ethyl-Diphosphate
DB03169 (S)-Hmg-Coa
DB03192 3r-Hydroxydecanoyl-Coa
DB03197 6-Hydroxymethylpterin
DB03211 (3-Formyl-but-3-Enyl)-Phosphonic Acid
DB03215 (2s,5s)-5-Carboxymethylproline
DB03216 (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine
DB03226 Trifluoroethanol
DB03227 Nicotinamide Mononucleotide
DB03229 2-Oxo-4-Methylpentanoic Acid
DB03247 Riboflavin Monophosphate
DB03273 3'-Oxo-Adenosine
DB03280 P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate
DB03310 Oxidized Glutathione Disulfide
DB03323 Maltose
DB03331 N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB03345 Beta-Mercaptoethanol
DB03382 S-Oxy Cysteine
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03416 Thiamin Phosphate
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03478 2'-O-Acetyl Adenosine-5-Diphosphoribose
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB03499 Malate Ion
DB03501 Uridine Diphosphate Galactose
DB03518 (R)-Mevalonate
DB03530 Acylated Ceftazidime
DB03534 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide
DB03548 3-Deoxy-D-Manno-Oct-2-Ulosonic Acid
DB03559 Cyclohexylformamide
DB03574 Ferricrocin-Iron
DB03589 Alpha-Ketomalonic Acid
DB03612 3-Hydroxybutyryl-Coenzyme A
DB03639 1-Guanidinium-7-Aminoheptane
DB03666 3'-Azido-3'-Deoxythymidine-5'-Monophosphate
DB03680 Tartronate
DB03703 Cyclohexanol
DB03704 12-Hydroxydodecanoic Acid
DB03723 2'-Deoxy-Thymidine-Beta-L-Rhamnose
DB03751 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose
DB03755 Adenosine-5'-[Beta, Gamma-Methylene]Tetraphosphate
DB03769 D-Eritadenine
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB03811 Histidinol
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03846 5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate
DB03867 Meta-Nitro-Tyrosine
DB03893 Thionicotinamide-Adenine-Dinucleotide
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB03940 Oxamic Acid
DB03948 6-Chloropurine Riboside, 5'-Monophosphate
DB03962 Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate
DB03969 3-Acetyl Pyridine Adenine Dinucleotide
DB04023 Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester
DB04030 1,3,4,9-Tetrahydro-2-(Hydroxybenzoyl)-9-[(4-Hydroxyphenyl)Methyl]-6-Methoxy-2h-Pyrido[3,4-B]Indole
DB04039 3-Oxo-Pentadecanoic Acid
DB04047 [Pterin-6-Yl Methanyl]-Phosphonophosphate
DB04065 N-Cyclopentyl-N-Cyclobutylformamide
DB04068 Fudp
DB04071 Cpad
DB04077 Glycerol
DB04097 Uridine-5'-Diphosphate-4-Deoxy-4-Fluoro-Alpha-D-Galactose
DB04099 Deamido-Nad+
DB04105 N-Heptylformamide
DB04113 N-Formylpiperidine
DB04122 Beta-D-Glucose-6-Phosphate
DB04137 Guanosine-5'-Triphosphate
DB04153 S-Hydroxymethyl Glutathione
DB04158 6-(Adenosine Tetraphosphate-Methyl)-7,8-Dihydropterin
DB04160 Diphosphate
DB04170 4-Bromo-3-Hydroxy-3-Methyl Butyl Diphosphate
DB04189 N2-(Carboxyethyl)-L-Arginine
DB04200 Matairesinol
DB04220 Rifamycin Cgp 4832
DB04267 Dipicolinic Acid
DB04272 Citric Acid
DB04279 3-Isopropylmalic Acid
DB04289 Genz-10850
DB04312 2,3-Difluorobenzyl Alcohol
DB04315 Guanosine-5'-Diphosphate
DB04355 Uridine-5'-Monophosphate Glucopyranosyl-Monophosphateester
DB04356 9-Deazaguanine
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB04381 Crotonaldehyde
DB04393 Diclosan
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04401 [Formylmethyl]Trimethyl-Ammonium, N,N,N-Trimethylammonium Acetaldehyde
DB04444 Tetrafluoroaluminate Ion
DB04447 1,4-Dithiothreitol
DB04448 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
DB04477 N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB04478 Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
DB04485 Deoxythymidine
DB04522 Phosphonoserine
DB04526 L-Glycero-D-Manno-Heptopyranose
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04551 Fructose-1,6-Diphosphate
DB04554 8-Bromoadenosine-5'-Diphosphate
DB04555 Cytidine-5'-Diphosphate
DB04566 Inosinic Acid
DB04610 7,8-dihydro-6-hydroxymethyl-7-methyl-7-[2-phenylethyl]-pterin
DB04640 Naphthalene-2,6-disulfonic acid
DB04641 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID
DB04786 Suramin
DB06770 Benzyl alcohol
DB07040 2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
DB07041 N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-7-yl)-2-methylpropyl]-4-phenoxybenzamide
DB07042 7-amino-2-tert-butyl-4-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidine-6-carboxamide
DB07043 7-amino-2-tert-butyl-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
DB07090 (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07123 N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
DB07155 (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE
DB07178 5-PENTYL-2-PHENOXYPHENOL
DB07188 (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07192 (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07222 (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07287 2-(2,4-DICHLOROPHENOXY)-5-(PYRIDIN-2-YLMETHYL)PHENOL
DB07347 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
DB07393 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE
DB07468 (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469 (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07470 (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07706 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE
DB07714 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID
DB07782 4-AMINO-2-TRIFLUOROMETHYL-5-HYDROXYMETHYLPYRIMIDINE PYROPHOSPHATE
DB08231 MYRISTIC ACID
DB08265 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL
DB08276 N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
DB08604 TRICLOSAN
DB08605 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
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