DT-Web

DB02301 - 5,10-Methylene-6-Hydrofolic Acid


Identification
Name 5,10-Methylene-6-Hydrofolic Acid
Accession Number DB02301 (EXPT03070)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 455.424
Groups experimental
Monoisotopic Weight 455.155331439
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0748
Folylpolyglutamate synthase
Name Folylpolyglutamate synthase
Gene Name fgs
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7007
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0748

Predictions


Id Partner name Gene Name Score
5435 Deoxycytidylate 5-hydroxymethyltransferase 42 0.1243
2567 Thymidylate synthase thyX thyX 0.1113
3586 Thymidylate synthase A thyA1 0.0984
24 Thymidylate synthase TMP1 0.0748
359 Thymidylate synthase TYMS 0.0748
5352 Thymidylate synthase THYA 0.0748
3596 Deoxynucleotide monophosphate kinase 1 0.0625
2617 Nitric oxide synthase oxygenase nos 0.0577
2701 Nitric oxide synthase oxygenase nos 0.0577
2257 Uridine phosphorylase udp 0.0447
5132 Uridine phosphorylase udp 0.0447
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0413
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0371
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0371
2555 Pol polyprotein pol 0.0339
3242 Pol polyprotein gag-pol 0.0339
3471 Pol polyprotein gag-pro-pol 0.0339
5256 Pol polyprotein pol 0.0339
6469 Pol polyprotein gag-pol 0.0339
6565 Pol polyprotein Not Available 0.0339
2621 Thermoresistant gluconokinase gntK 0.0315
5466 Putative sugar kinase STM4066 0.0315
4517 Probable butyrate kinase 2 buk2 0.0315
2878 Probable serine/threonine-protein kinase pknB pknB 0.0315
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.029
5312 Kinesin-like protein KIF1A KIF1A 0.029
3669 Ribokinase rbsK 0.0274
2615 Chemotaxis protein cheA cheA 0.0274
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0262
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
2757 Inorganic pyrophosphatase ppa 0.0261
6238 Inorganic pyrophosphatase ppa 0.0261
6968 Inorganic pyrophosphatase PPA1 0.0261
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0253
4680 Amicyanin mauC 0.0251
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0249
3575 Uracil phosphoribosyltransferase upp 0.0249
3600 Uracil phosphoribosyltransferase upp 0.0249
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0249
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0249
3168 Beta-lactamase OXA-1 bla 0.0247
4819 Hydrolase Not Available 0.0247
5249 Hydrolase Not Available 0.0247
5436 Hydrolase Not Available 0.0247
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0247
3122 D-hydantoinase Not Available 0.0247
3145 D-hydantoinase hyuA 0.0247
3747 Cellulase B precursor celB 0.0231
4681 Aminopeptidase Not Available 0.0231
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0228
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0227
2647 RNA-directed RNA polymerase P2 0.0227
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0227
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0227
36 Insulin receptor INSR 0.0224
48 Pyridoxal kinase PDXK 0.022
4276 DNA polymerase III subunit epsilon dnaQ 0.0216
4275 PCZA361.16 Not Available 0.0216
3292 Alanine racemase, catabolic dadX 0.0215
3281 Isoaspartyl dipeptidase iadA 0.0215
3237 Beta-lactamase OXA-2 bla 0.0215
4264 Alpha-L-fucosidase, putative TM_0306 0.0215
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0215
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0215
3257 Bifunctional polymyxin resistance protein arnA arnA 0.0214
2149 Angiogenin ANG 0.021
3010 Regulatory protein blaR1 blaR1 0.021
6513 Urease subunit gamma ureA 0.0206
6512 Urease subunit beta ureB 0.0205
6511 Urease subunit alpha ureC 0.0205
6514 Probable rRNA methylase TTHA1387 0.0205
1353 DNA topoisomerase 1 TOP1 0.0204
3552 DNA topoisomerase 1 topA 0.0204
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0199
2590 Galactose-1-phosphate uridylyltransferase galT 0.0199
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0198
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0198
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0198
4600 Malonamidase E2 Not Available 0.0198
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0198
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0198
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0198
4272 POSSIBLE CELLULASE CELA1 celA1 0.0192
2727 S-adenosylmethionine synthetase metK 0.0189
2646 Dihydroorotase pyrC 0.0187
4549 Endonuclease III HP_0602 0.0187
2251 Thymidylate kinase tmk 0.018
2254 Thymidylate kinase DTYMK 0.018
3522 Thymidylate kinase tmk 0.018
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0177
2340 Beta-lactamase PSE-2 bla 0.0169
6395 Myosin-14 MYH14 0.0168
2796 Parathion hydrolase opd 0.0168
6539 Parathion hydrolase opd 0.0168
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0166
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0165
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0165
894 Alanine racemase alr 0.0163
2453 Alanine racemase alr 0.0163
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.016
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0159
509 Thymidine kinase TK 0.015
570 Thymidine kinase TK 0.015
2559 Thymidine kinase TK 0.015
3430 Thymidine kinase tdk 0.015
3518 Thymidine kinase TK 0.015
5301 Thymidine kinase tdk 0.015
5771 Thymidine kinase ORF36 0.015
7009 Thymidine kinase ORF36 0.015
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0141
5294 Nucleoside diphosphate kinase A NME1 0.014
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.012
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0096
5694 Transcription antiterminator licT licT 0.0096
3361 Serpin B5 SERPINB5 0.0096
2240 Cell division protein kinase 2 CDK2 0.0093
56 Delta-aminolevulinic acid dehydratase ALAD 0.0077
2356 Delta-aminolevulinic acid dehydratase hemB 0.0077
3613 Delta-aminolevulinic acid dehydratase hemB 0.0077
3674 Delta-aminolevulinic acid dehydratase hemB 0.0077
2286 Isocitrate dehydrogenase [NADP] icd 0.0073
2302 Isocitrate dehydrogenase [NADP] icd 0.0073
2771 Isocitrate dehydrogenase [NADP] icd 0.0073
4534 Cytohesin-2 CYTH2 0.0069
3668 Maltose-binding periplasmic protein precursor malE 0.0067
5669 50S ribosomal protein L27 rpmA 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5675 Chaperone protein torD torD 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
2592 Beta-galactosidase lacZ 0.0059
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0057
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0057
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0057
2636 Shikimate dehydrogenase aroE 0.0057
3515 Shikimate dehydrogenase aroE 0.0057
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
315 Arginase-1 ARG1 0.0057
2280 Listeriolysin regulatory protein prfA 0.0052
4811 Amylosucrase ams 0.0052
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0052
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0052
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0051
3191 Histidinol dehydrogenase hisD 0.0049
191 Peptide methionine sulfoxide reductase MSRA 0.0047
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0047
909 Maleylacetoacetate isomerase GSTZ1 0.0046
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
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