DT-Web

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase


Partner ID 6609
Name 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms 4220
Gene name ispF
General function Lipid transport and metabolism
Specific function Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP. Also converts 4-diphosphocytidyl-2-C-methyl-D- erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP
Gene sequence + ...

ATGCGAATTGGACACGGTTTTGACGTACATGCCTTTGGCGGTGAAGGCCCAATTATCATTGGTGGCGTACGCATTCCTTACGAAAAAGGATTGCTGGCGCATTCTGATGGCGACGTGGCGCTCCATGCGTTGACCGATGCATTGCTTGGCGCGGCGGCGCTGGGGGATATCGGCAAGCTGTTCCCGGATACCGATCCGGCATTTAAAGGTGCCGATAGCCGCGAGCTGCTACGCGAAGCCTGGCGTCGTATTCAGGCGAAGGGTTATACCCTTGGCAACGTCGATGTCACTATCATCGCTCAGGCACCGAAGATGTTGCCGCACATTCCACAAATGCGCGTGTTTATTGCCGAAGATCTCGGCTGCCATATGGATGATGTTAACGTGAAAGCCACTACTACGGAAAAACTGGGATTTACCGGACGTGGGGAAGGGATTGCCTGTGAAGCGGTGGCGCTACTCATTAAGGCAACAAAATGA
Protein sequence + ...

MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
GO Classification
function
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
catalytic activity
lyase activity
phosphorus-oxygen lyase activity
process
polyisoprenoid metabolism
terpenoid metabolism
terpenoid biosynthesis
physiological process
metabolism
primary metabolism
lipid metabolism
cellular lipid metabolism
isoprenoid metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02552 Geranyl Diphosphate

Associated as Prediction

Id Name
DB00282 Pamidronate
DB00300 Tenofovir
DB00352 Thioguanine
DB00399 Zoledronate
DB00441 Gemcitabine
DB00563 Methotrexate
DB00630 Alendronate
DB00695 Furosemide
DB00709 Lamivudine
DB00710 Ibandronate
DB00718 Adefovir Dipivoxil
DB00789 Gadopentetate dimeglumine
DB00814 Meloxicam
DB00851 Dacarbazine
DB00867 Ritodrine
DB00884 Risedronate
DB00920 Ketotifen
DB00993 Azathioprine
DB01033 Mercaptopurine
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01785 Dimethylallyl Diphosphate
DB01788 4-Imino-5-Methidyl-2-Methylpyrimidine
DB01859 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol 2-Phosphate
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01944 (S)-blebbistatin
DB01972 Guanosine-5'-Monophosphate
DB02075 (1s)-1(9-Deazahypoxanthin-9yl)1,4-Dideoxy-1,4-Imino-D-Ribitol-5-Phosphate
DB02076 6-Phosphogluconic Acid
DB02097 Cytidine
DB02153 3-Sulfinoalanine
DB02175 Malonic acid
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB02212 Pyrophosphate 2-
DB02254 Trifluoro-thiamin phosphate
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
DB02344 O-Sialic Acid (Chair Conformation)
DB02345 Selenocysteine
DB02431 Cytidine-5'-Triphosphate
DB02456 Cytosine Arabinose-5'-Phosphate
DB02475 Deoxyguanidinoproclavaminic acid
DB02508 Isopentyl Pyrophosphate
DB02521 2,5,7-Trihydroxynaphthoquinone
DB02552 Geranyl Diphosphate
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB02607 Adenosine Phosphonoacetic Acid
DB02649 3-Amino-3-Oxopropanoic Acid
DB02883 2',3'-Dideoxycytidine-5'-Monophosphate
DB02885 4-Imino-5-Methidyl-2-Trifluoromethylpyrimidine
DB02887 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate
DB02968 Penicillin G Acyl-Serine
DB03075 (Diphosphono)Aminophosphonic Acid
DB03088 Pyroglutamic Acid
DB03103 Thymidine-5'- Diphosphate
DB03126 Mant-Adp
DB03145 4-Methyl-5-Hydroxyethylthiazole Phosphate
DB03153 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol
DB03403 Cytidine-5'-Monophosphate
DB03416 Thiamin Phosphate
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB03530 Acylated Ceftazidime
DB03664 P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate
DB03687 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol
DB03755 Adenosine-5'-[Beta, Gamma-Methylene]Tetraphosphate
DB03801 Lysine Nz-Carboxylic Acid
DB03854 Pentane-1,5-Diamine
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB03961 2c-Methyl-D-Erythritol 2,4-Cyclodiphosphate
DB03962 Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate
DB04005 Uridine 5'-Triphosphate
DB04068 Fudp
DB04099 Deamido-Nad+
DB04137 Guanosine-5'-Triphosphate
DB04189 N2-(Carboxyethyl)-L-Arginine
DB04272 Citric Acid
DB04315 Guanosine-5'-Diphosphate
DB04356 9-Deazaguanine
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04444 Tetrafluoroaluminate Ion
DB04464 N-Formylmethionine
DB04482 Cmp-2-Keto-3-Deoxy-Octulosonic Acid
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04554 8-Bromoadenosine-5'-Diphosphate
DB04555 Cytidine-5'-Diphosphate
DB04695 FARNESYL THIOPYROPHOSPHATE
DB04702 S-[(2E)-3,7-DIMETHYLOCTA-2,6-DIENYL] TRIHYDROGENTHIODIPHOSPHATE
DB04714 ISOPENTENYL PYROPHOSPHATE
DB06830 (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06931 (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06953 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
DB07216 (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
DB07221 (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
DB07227 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
DB07404 (1-HYDROXY-1-PHOSPHONO-2-[1,1';3',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
DB07409 (1-HYDROXY-1-PHOSPHONO-2-[1,1';4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
DB07410 [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
DB07426 [1-HYDROXY-2-(1,1':3',1''-TERPHENYL-3-YLOXY)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)
DB07468 (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469 (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07470 (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07661 1,6-DIHYDROXY NAPHTHALENE
DB07752 FARNESYL
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
DB07780 FARNESYL DIPHOSPHATE
DB07782 4-AMINO-2-TRIFLUOROMETHYL-5-HYDROXYMETHYLPYRIMIDINE PYROPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB07873 (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB07895 ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
DB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
DB08276 N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
DB08529 (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
DB08674 (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
DB08676 (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
↑