DT-Web: DB00718

Identification

Name

Adefovir Dipivoxil

Accession Number

DB00718 (APRD00781)

Type

small molecule

Description

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. [Wikipedia] Adefovir dipivoxil is the diester prodrug of adefovir.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

501.4705

Groups

approved

Monoisotopic Weight

501.198849537

Pharmacology

Indication

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Mechanism of action

Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 μM. Adefovir diphosphate is a weak inhibitor of human DNA polymerases α and γ with Ki values of 1.18 μM and 0.97μM, respectively.

Absorption

The approximate oral bioavailability of adefovir from HEPSERA is 59%. When a single oral 10 mg dose is given to chronic hepatitis B patients, the peak plasma concentration (Cmax) of adefovir was 18.4 ? 6.26 ng/mL. This occurred between 0.58 - 4 hours post dose (Tmax). The adefovir area under the plasma concentration-time curve (AUC0-?) was 220 ? 70.0 ng?h/mL. Food does not affect the exposure of adeforvir.

Protein binding

≤4% over the adefovir concentration range of 0.1 to 25 μg/mL

Biotransformation

Following oral administration, adefovir dipivoxil is rapidly converted to adefovir. 45% of the dose is recovered as adefovir in the urine over 24 hours at steady state following 10 mg oral doses. Adefovir is not a substrate of the cytochrome P450 enzymes.

Route of elimination

Adefovir is renally excreted by a combination of glomerular filtration and active tubular secretion.

Toxicity

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

Affected organisms

Hepatitis B virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Valganciclovir	The adverse/toxic effects of reverse transcriptase inhibitors (nucleoside), such as Adefovir Dipivoxil, may be enhanced by Valganciclovir. There is a risk of hematologic toxicity. Diligent monitoring during concomitant therapy is recommended.

Food Interactions

Take without regard to meals.

P protein [Includes: DNA-directed DNA polymerase
Name	P protein [Includes: DNA-directed DNA polymerase
Gene Name	P
Pharmacological action	yes
Actions	other
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chien RN, Liaw YF: Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92. - Pubmed Kock J, Baumert TF, Delaney WE 4th, Blum HE, von Weizsacker F: Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes. Hepatology. 2003 Dec;38(6):1410-8. - Pubmed
DTHybrid score	0.3602

Adenylate kinase 2, mitochondrial
Name	Adenylate kinase 2, mitochondrial
Gene Name	AK2
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	Not Available
GTP:AMP phosphotransferase AK4, mitochondrial
Name	GTP:AMP phosphotransferase AK4, mitochondrial
Gene Name	Not Available
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	Not Available
Nucleoside diphosphate kinase A
Name	Nucleoside diphosphate kinase A
Gene Name	NME1
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	1.2831
Nucleoside diphosphate kinase B
Name	Nucleoside diphosphate kinase B
Gene Name	NME2
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	0.3572

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate,inhibitor
References	Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. - Pubmed Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999 Sep;56(3):570-80. - Pubmed Ho ES, Lin DC, Mendel DB, Cihlar T: Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol. 2000 Mar;11(3):383-93. - Pubmed
DTHybrid score	0.4617
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, Fridland A: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med. 1999 Sep;5(9):1048-51. - Pubmed
DTHybrid score	0.3705
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	substrate
References	Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P: Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81. - Pubmed
DTHybrid score	0.2738
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	substrate
References	Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. - Pubmed
DTHybrid score	0.2652
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA155028030 -
DTHybrid score	0.3944

Id	Partner name	Gene Name	Score
612	P protein [Includes: DNA-directed DNA polymerase	P	0.3602
1024	Solute carrier family 22 member 11	SLC22A11	0.1245
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1088
6143	Solute carrier family 22 member 7	SLC22A7	0.1049
6144	Solute carrier family 22 member 2	SLC22A2	0.0963
6145	Solute carrier family 22 member 1	SLC22A1	0.0935
1588	Multidrug resistance protein 1	ABCB1	0.0869
4757	Cytochrome P450 2C9	CYP2C9	0.0813
4512	Cytochrome P450 3A4	CYP3A4	0.0799
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0774
587	Serum albumin	ALB	0.0749
862	Multidrug resistance-associated protein 1	ABCC1	0.0708
118	Organic cation/carnitine transporter 2	SLC22A5	0.0699
4200	Cytochrome P450 1A2	CYP1A2	0.0665
2633	Anaerobic ribonucleoside-triphosphate reductase	NRDD	0.0662
6148	Multidrug resistance-associated protein 7	ABCC10	0.0633
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0621
4924	Cytochrome P450 2C8	CYP2C8	0.0605
290	Prostaglandin G/H synthase 2	PTGS2	0.0574
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0572
2638	Formate dehydrogenase H	fdhF	0.0571
20	Prostaglandin G/H synthase 1	PTGS1	0.0517
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0516
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0512
6016	Cytochrome P450 2C19	CYP2C19	0.0489
2748	Cysteine desulfurase	sufS	0.0433
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0432
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0421
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0409
833	Organic cation/carnitine transporter 1	SLC22A4	0.0405
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0398
4119	Cytochrome P450 2D6	CYP2D6	0.0394
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.039
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0366
4118	Cytochrome P450 3A5	CYP3A5	0.0359
702	UMP-CMP kinase	CMPK1	0.034
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0335
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0316
776	Bile salt export pump	ABCB11	0.0307
6107	Cytochrome P450 3A7	CYP3A7	0.0304
4773	Deoxycytidine kinase	DCK	0.0301
6141	Sodium/bile acid cotransporter	SLC10A1	0.0292
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0291
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.029
6030	Cytochrome P450 2B6	CYP2B6	0.0283
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0283
6024	Cytochrome P450 1A1	CYP1A1	0.0282
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0281
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0276
6013	Cytochrome P450 2E1	CYP2E1	0.0271
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0269
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.026
3685	Catabolite gene activator	crp	0.0256
4655	Adenylate cyclase	cyaC	0.0255
4759	Adenylate cyclase	cyaB2	0.0255
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.025
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0244
738	Monocarboxylate transporter 1	SLC16A1	0.0244
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0239
5718	Cytochrome P450 2A6	CYP2A6	0.0238
1405	Thiopurine S-methyltransferase	TPMT	0.0233
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0221
3947	Xanthine dehydrogenase/oxidase	XDH	0.0219
6020	Aldehyde oxidase	AOX1	0.0218
4760	Mll3241 protein	mll3241	0.0218
338	DNA polymerase	UL30	0.0216
379	DNA polymerase	UL54	0.0216
697	DNA polymerase	ORF28	0.0216
2482	DNA polymerase	43	0.0216
4104	DNA polymerase	BALF5	0.0216
645	Penicillin-binding protein 1A	mrcA	0.0212
5805	Penicillin-binding protein 1A	ponA	0.0212
6185	Penicillin-binding protein 1A	mrcA	0.0212
6799	Penicillin-binding protein 1A	pbpA	0.0212
6137	Multidrug resistance-associated protein 6	ABCC6	0.0208
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0205
24	Thymidylate synthase	TMP1	0.0198
359	Thymidylate synthase	TYMS	0.0198
2626	Thymidylate synthase	thyA	0.0198
2729	Thymidylate synthase	thyA	0.0198
5352	Thymidylate synthase	THYA	0.0198
2016	Dipeptidase 1	DPEP1	0.0197
633	Penicillin-binding proteins 1A/1B	pbpA	0.0195
543	Penicillin-binding protein 1B	mrcB	0.019
6186	Penicillin-binding protein 1B	ponB	0.019
6822	Penicillin-binding protein 1b	pbp1b	0.019
6844	Penicillin-binding protein 1b	pbp1b	0.019
1882	Ras-related C3 botulinum toxin substrate 1	RAC1	0.0187
2170	Transforming protein RhoA	RHOA	0.0187
3197	GDP-mannose mannosyl hydrolase	nudD	0.0187
5628	Probable GTPase engC	rsgA	0.0187
5630	ADP-ribosylation factor-like protein 5A	ARL5A	0.0187
5618	ADP-ribosylation factor 4	ARF4	0.0187
5624	GTPase	rab6	0.0187
5627	GDP-mannose 4,6-dehydratase	gca	0.0187
3366	GTP-binding protein engA	der	0.0187
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0181
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0176
3115	Ras-related protein Rab-9	RAB9A	0.0175
3639	Thymidine phosphorylase	deoA	0.0175
3936	Thymidine phosphorylase	TYMP	0.0175
22	30S ribosomal protein S4	rpsD	0.0173
6714	30S ribosomal protein S4	rpsD	0.0173
378	Alpha-2C adrenergic receptor	ADRA2C	0.0169
6171	Solute carrier family 28 member 3	SLC28A3	0.0166
6085	Fatty acid-binding protein, intestinal	FABP2	0.0166
6167	Organic solute transporter subunit beta	OSTB	0.0163
140	30S ribosomal protein S9	rpsI	0.0163
6719	30S ribosomal protein S9	rpsI	0.0163
6725	30S ribosomal protein S9	rpsI	0.0163
6166	Organic solute transporter subunit alpha	OSTA	0.0163
3335	Probable GTP-binding protein engB	engB	0.0162
3354	Ras-related protein Rap-2a	RAP2A	0.0162
3107	Putative GTP pyrophosphokinase	relA	0.0162
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0162
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0161
5619	GDP-mannose 4,6 dehydratase	GMDS	0.0161
3170	Elongation factor Tu-B	tufB	0.0157
3396	Elongation factor Tu	tufA	0.0156
5621	Elongation factor Tu	tuf	0.0156
3270	Elongation factor G	fusA	0.0156
3261	Signal recognition particle protein	ffh	0.0155
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0153
2320	Thymidine kinase, cytosolic	TK1	0.0152
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
4604	Liver carboxylesterase 1	CES1	0.0149
124	Histamine H2 receptor	HRH2	0.0148
6149	Solute carrier family 22 member 10	SLC22A10	0.0148
3957	Adenosine deaminase	ADA	0.0145
6750	ADP-ribosylation factor 6	ARF6	0.0145
2521	Cell division protein ftsZ	ftsZ	0.0145
3301	Cell division protein ftsZ	ftsZ	0.0145
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6556	Elongation factor Tu GTP-binding domain-containing protein 1	EFTUD1	0.0141
592	Carbonic anhydrase 4	CA4	0.0141
1596	Protein-glutamine gamma-glutamyltransferase 2	TGM2	0.0141
6447	Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	0.0141
404	DNA gyrase subunit A	gyrA	0.0139
6224	DNA gyrase subunit A	gyrA	0.0139
4217	Telomerase reverse transcriptase	TERT	0.0137
6790	Elongation factor 2	EEF2	0.0136
295	Carbonic anhydrase 1	CA1	0.0133
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0133
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0133
357	Carbonic anhydrase 2	CA2	0.0131
1758	GTPase HRas	HRAS	0.0129
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0127
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0127
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
1636	Trace amine-associated receptor 1	TAAR1	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
6316	ADP-ribosylation factor 1	ARF1	0.0121
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.012
629	Alpha-2B adrenergic receptor	ADRA2B	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0115
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0115
2632	Adenylosuccinate synthetase	purA	0.0113
3323	Adenylosuccinate synthetase	purA	0.0113
3975	Adenylosuccinate synthetase	ADSS	0.0113
4598	Adenylosuccinate synthetase	Adss	0.0113
6817	Adenylosuccinate synthetase	purA	0.0113
2472	Voltage-gated potassium channel	kcsA	0.0112
6366	Voltage-gated potassium channel	kcsA	0.0112
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0107
1757	Myeloperoxidase	MPO	0.0107
318	Alpha-2A adrenergic receptor	ADRA2A	0.0106
115	Penicillin-binding protein 2	mrdA	0.0106
6069	Penicillin-binding protein 2	mrdA	0.0106
6118	Penicillin-binding protein 2	penA	0.0106
6187	Penicillin-binding protein 2	pbpA	0.0106
6686	Penicillin-binding protein 2	pbp2	0.0106
6939	Penicillin-binding protein 2	mrdA	0.0106
7163	Penicillin-binding protein 2	pbpA	0.0106
3941	Amine oxidase [flavin-containing] A	MAOA	0.0105
6106	Cytochrome P450 2C18	CYP2C18	0.0104
4226	Uridine phosphorylase 2	UPP2	0.0103
5482	Sialidase-2	NEU2	0.0101
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0101
6033	High affinity interleukin-8 receptor A	CXCR1	0.01
3811	Cytochrome P450 19A1	CYP19A1	0.0099
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0099
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0099
1	Peptidoglycan synthetase ftsI	ftsI	0.0099
4155	Peptidoglycan synthetase ftsI	ftsI	0.0099
887	DNA gyrase subunit B	gyrB	0.0099
4150	DNA gyrase subunit B	gyrB	0.0099
6225	DNA gyrase subunit B	gyrB	0.0099
131	Synaptic vesicular amine transporter	SLC18A2	0.0098
713	Sodium-dependent dopamine transporter	SLC6A3	0.0098
556	Alpha-1A adrenergic receptor	ADRA1A	0.0098
558	Solute carrier family 12 member 1	SLC12A1	0.0098
1198	Serum paraoxonase/arylesterase 1	PON1	0.0097
6223	Penicillin-binding protein 1C	pbpC	0.0097
293	Gamma-glutamyl hydrolase	GGH	0.0096
2757	Inorganic pyrophosphatase	ppa	0.0096
6238	Inorganic pyrophosphatase	ppa	0.0096
6968	Inorganic pyrophosphatase	PPA1	0.0096
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0096
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0095
3923	Cholinesterase	BCHE	0.0095
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0095
908	Glutathione S-transferase theta-1	GSTT1	0.0095
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0093
4225	Uridine phosphorylase 1	UPP1	0.0091
5353	Glutamate decarboxylase alpha	gadA	0.0091
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0091
6218	Pannexin-1	PANX1	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
5126	Arginase	rocF	0.0088
413	Amidophosphoribosyltransferase	PPAT	0.0088
2515	Amidophosphoribosyltransferase	purF	0.0088
3714	Amidophosphoribosyltransferase	purF	0.0088
1898	Cytochrome P450 1B1	CYP1B1	0.0087
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0087
161	Tubulin beta chain	TUBB	0.0085
312	Tubulin beta chain	TUB2	0.0085
1650	Heme carrier protein 1	SLC46A1	0.0085
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0084
492	Histamine H1 receptor	HRH1	0.0084
2647	RNA-directed RNA polymerase	P2	0.0084
373	Transthyretin	TTR	0.0084
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0083
723	Cytosolic phospholipase A2	PLA2G4A	0.0083
896	Glutathione S-transferase Mu 1	GSTM1	0.0083
6070	Nischarin	NISCH	0.0083
2727	S-adenosylmethionine synthetase	metK	0.0083
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0083
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0083
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0082
6126	Carbonic anhydrase 7	CA7	0.0082
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.008
740	Argininosuccinate synthase	ASS1	0.0079
865	Argininosuccinate synthase	ASS1	0.0079
2680	Argininosuccinate synthase	argG	0.0079
3194	Argininosuccinate synthase	argG	0.0079
332	Beta-lactamase	blaZ	0.0079
2478	Beta-lactamase	ampC	0.0079
2613	Beta-lactamase	ampC	0.0079
2635	Beta-lactamase	ampC	0.0079
2700	Beta-lactamase	penP	0.0079
5445	Beta-lactamase	blaB	0.0079
6019	Beta-lactamase	SHV-7	0.0079
6701	Beta-lactamase	cphA	0.0079
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0078
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0078
3010	Regulatory protein blaR1	blaR1	0.0077
2149	Angiogenin	ANG	0.0077
275	Arachidonate 5-lipoxygenase	ALOX5	0.0076
756	Sex hormone-binding globulin	SHBG	0.0075
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0074
904	Glutathione S-transferase P	GSTP1	0.0074
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0074
6165	Copper-transporting ATPase 1	ATP7A	0.0073
6163	Copper-transporting ATPase 2	ATP7B	0.0073
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0073
6395	Myosin-14	MYH14	0.0073
4600	Malonamidase E2	Not Available	0.0072
1648	Elastin	ELN	0.0072
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0071
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
718	Folate receptor gamma	FOLR3	0.0071
299	Folate receptor beta	FOLR2	0.0071
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0071
6014	Cytochrome P450 2A13	CYP2A13	0.007
6031	Cytochrome P450 3A43	CYP3A43	0.007
2717	Folylpolyglutamate synthase	fgs	0.007
6146	High affinity copper uptake protein 1	SLC31A1	0.007
624	Guanidinoacetate N-methyltransferase	GAMT	0.0069
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0069
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0069
766	Beta-2 adrenergic receptor	ADRB2	0.0069
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0069
789	Alpha-1D adrenergic receptor	ADRA1D	0.0068
1867	Major prion protein	PRNP	0.0067
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0067
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0067
952	Dipeptidyl peptidase 4	DPP4	0.0066
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0065
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0065
477	DNA topoisomerase 4 subunit A	parC	0.0064
886	DNA topoisomerase 4 subunit A	parC	0.0064
6226	DNA topoisomerase 4 subunit A	parC	0.0064
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0063
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0063
146	Androgen receptor	AR	0.0062
136	Estrogen receptor	ESR1	0.0062
3939	Amine oxidase [flavin-containing] B	MAOB	0.0062
468	Cytochrome P450 4A11	CYP4A11	0.0062
6138	Multidrug resistance protein 3	ABCB4	0.0061
3587	Gastrotropin	FABP6	0.0061
130	Prostacyclin synthase	PTGIS	0.0061
244	Angiotensin-converting enzyme	ACE	0.0061
3932	Glutathione S-transferase A2	GSTA2	0.006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.006
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
824	Sodium-dependent serotonin transporter	SLC6A4	0.006
6220	Aryl hydrocarbon receptor	AHR	0.006
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0059
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
6207	30S ribosomal protein S14	rpsN	0.0058
6209	30S ribosomal protein S19	rpsS	0.0058
6712	30S ribosomal protein S19	rpsS	0.0058
6726	30S ribosomal protein S19	rpsS	0.0058
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0058
5682	Ribonuclease pancreatic	RNASE1	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
1313	Lactoylglutathione lyase	GLO1	0.0057
33	Cystine/glutamate transporter	SLC7A11	0.0057
489	Monocarboxylate transporter 2	SLC16A7	0.0057
1341	Histamine H3 receptor	HRH3	0.0057
6043	Putative G-protein coupled receptor 44	GPR44	0.0057
2249	Aspartate aminotransferase	aspC	0.0056
2671	Aspartate aminotransferase	aspC	0.0056
5490	Aspartate aminotransferase	Not Available	0.0056
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0055
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0054
164	Histamine H4 receptor	HRH4	0.0054
408	Riboflavin kinase	RFK	0.0053
2021	Thrombomodulin	THBD	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
465	Calmodulin	CALM1	0.0052
65	Matrix metalloproteinase-9	Not Available	0.0051
504	Mast/stem cell growth factor receptor	KIT	0.0051
3810	Catechol O-methyltransferase	COMT	0.0051
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
26	Vascular endothelial growth factor receptor 3	FLT4	0.0051
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.005
2300	Lysozyme	E	0.005
3633	Lysozyme	R	0.005
5597	Lysozyme	17	0.005
165	FL cytokine receptor	FLT3	0.005
527	Prostacyclin receptor	PTGIR	0.005
672	Prostaglandin F2-alpha receptor	PTGFR	0.0049
632	Alpha-1B adrenergic receptor	ADRA1B	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
32	Vascular endothelial growth factor receptor 1	FLT1	0.0048
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0047
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
29	Tubulin beta-1 chain	TUBB1	0.0046
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0046
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0045
1654	Interleukin-1 beta	IL1B	0.0045
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4203	Histamine N-methyltransferase	HNMT	0.0043
817	DNA topoisomerase 2-alpha	TOP2A	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
53	Solute carrier family 12 member 5	SLC12A5	0.0042
663	Solute carrier family 12 member 4	SLC12A4	0.0042
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0042
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0042
2539	Tubulin alpha-1 chain	TUBA4A	0.0042
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0041
207	Glutathione synthetase	GSS	0.004
5269	Glutathione synthetase	gshB	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.004
5818	Folate receptor alpha	FOLR1	0.004
4034	Glutaredoxin-1	GLRX	0.004
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.004
4037	Hypothetical protein	GPX1	0.004
4297	Hypothetical protein	SP_1951	0.004
4521	Hypothetical protein	BC_2969	0.004
4540	Hypothetical protein	TM_1070	0.004
4555	Hypothetical protein	MT1739	0.004
4569	Hypothetical protein	mshD	0.004
4578	Hypothetical protein	PA3270	0.004
4747	Hypothetical protein	PA3967	0.004
5177	Hypothetical protein	TM_0096	0.004
5194	Hypothetical protein	PA1204	0.004
5240	Hypothetical protein	Rv2991	0.004
5370	Hypothetical protein	TM_1158	0.004
5710	Hypothetical protein	Tb927.5.1360	0.004
1928	Leukotriene C4 synthase	LTC4S	0.004
4029	Microsomal glutathione S-transferase 3	MGST3	0.004
4032	Microsomal glutathione S-transferase 1	MGST1	0.004
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.004
4035	Glutathione S-transferase Mu 5	GSTM5	0.004
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.004
4040	Glutathione peroxidase 7	GPX7	0.004
910	Epididymal secretory glutathione peroxidase	GPX5	0.004
4036	Glutathione peroxidase 6	GPX6	0.004
903	Glutathione S-transferase A5	GSTA5	0.004
911	Glutathione peroxidase 3	GPX3	0.004
906	Glutathione peroxidase 1	GPX1	0.004
900	Glutathione S-transferase A4	GSTA4	0.004
4038	Glutathione peroxidase 4	GPX4	0.004
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.004
4042	Glutathione transferase omega-2	GSTO2	0.004
907	Glutathione peroxidase 2	GPX2	0.004
4033	S-formylglutathione hydrolase	ESD	0.004
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.004
380	Cytochrome P450 17A1	CYP17A1	0.0039
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0039
310	Solute carrier family 12 member 2	SLC12A2	0.0039
6042	Prostaglandin reductase 2	PTGR2	0.0039
6432	Transporter	snf	0.0039
407	Vascular endothelial growth factor receptor 2	KDR	0.0039
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0038
494	Caspase-1	CASP1	0.0037
1792	Tissue-type plasminogen activator	PLAT	0.0037
183	Vascular endothelial growth factor A	VEGFA	0.0036
284	DNA-directed RNA polymerase beta chain	rpoB	0.0036
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0036
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0036
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0036
273	Apoptosis regulator Bcl-2	BCL2	0.0036
897	Glutathione S-transferase kappa 1	GSTK1	0.0035
6131	Carbonic anhydrase 14	CA14	0.0035
898	Glutathione S-transferase A3	GSTA3	0.0035
1507	Cytochrome c	CYCS	0.0035
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0035
909	Maleylacetoacetate isomerase	GSTZ1	0.0035
899	Glutathione S-transferase Mu 3	GSTM3	0.0034
905	Glutathione transferase omega-1	GSTO1	0.0034
193	Beta-1 adrenergic receptor	ADRB1	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
4041	Microsomal glutathione S-transferase 2	MGST2	0.0034
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0034
3927	Choline transporter-like protein 3	SLC44A3	0.0034
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0034
769	High-affinity choline transporter 1	SLC5A7	0.0034
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0034
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0034
1686	Choline transporter-like protein 1	SLC44A1	0.0034
3926	Choline transporter-like protein 2	SLC44A2	0.0034
861	Choline kinase alpha	CHKA	0.0034
700	Choline dehydrogenase, mitochondrial	CHDH	0.0034
3925	Choline transporter-like protein 4	SLC44A4	0.0034
576	Choline O-acetyltransferase	CHAT	0.0034
3922	Phospholipase D2	PLD2	0.0034
3924	Phospholipase D1	PLD1	0.0034
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0032
758	Thyroid hormone receptor alpha	THRA	0.0031
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
2077	Caspase-3	CASP3	0.0031
2165	Glutathione S-transferase Mu 2	GSTM2	0.0031
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.003
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.003
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.003
1517	Beta-3 adrenergic receptor	ADRB3	0.003
819	Penicillin-binding protein 4	dacB	0.003
153	Dopamine beta-hydroxylase	DBH	0.003
654	Flavin reductase	BLVRB	0.0029
901	Glutathione S-transferase Mu 4	GSTM4	0.0029
828	Phenylalanine-4-hydroxylase	PAH	0.0029
3109	Phenylalanine-4-hydroxylase	phhA	0.0029
2391	Ferrochelatase	hemH	0.0029
6502	Ferrochelatase	DKFZp686P18130	0.0029
1591	Ferrochelatase, mitochondrial	FECH	0.0029
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0028
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0027
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0027
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0027
1025	Aquaporin-1	AQP1	0.0027
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0027
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0027
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0027
4031	Glutathione S-transferase A1	GSTA1	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
714	Glutathione reductase, mitochondrial	GSR	0.0025
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0025
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0025
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0025
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0025
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0025
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0025
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0025
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0025
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0025
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0025
6559	Cytochrome c oxidase subunit 2	ctaC	0.0025
6669	Cytochrome c oxidase subunit 2	ctaC	0.0025
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0025
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0025
6558	Cytochrome c oxidase subunit 1	ctaD	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0024
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0023
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0023
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0023
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0023
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0023
2540	Choloylglycine hydrolase	cbh	0.0023
1039	Histone deacetylase 9	HDAC9	0.0023
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0022
163	D(1B) dopamine receptor	DRD5	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
6501	Fatty acid-binding protein, liver	FABP1	0.0022
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
6168	Solute carrier family 22 member 16	SLC22A16	0.0021
6151	Monocarboxylate transporter 10	SLC16A10	0.0021
432	D(4) dopamine receptor	DRD4	0.0021
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0021
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0021
365	Dihydrofolate reductase	DHFR	0.0021
2381	Dihydrofolate reductase	DFR1	0.0021
2833	Dihydrofolate reductase	Not Available	0.0021
2931	Dihydrofolate reductase	folA	0.0021
3544	Dihydrofolate reductase	folA	0.0021
3682	Dihydrofolate reductase	folA	0.0021
6642	Dihydrofolate reductase	folA	0.0021
6756	Dihydrofolate reductase	dfrA	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0021
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
737	Mineralocorticoid receptor	NR3C2	0.0021
638	D(3) dopamine receptor	DRD3	0.0021
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.002
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.002
869	Estrogen receptor beta	ESR2	0.0019
1714	Mitogen-activated protein kinase 3	MAPK3	0.0019
3809	Estrogen-related receptor gamma	ESRRG	0.0019
614	Progesterone receptor	PGR	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
23	D(1A) dopamine receptor	DRD1	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0018
6500	Phospholipase A2	PLA2G1B	0.0018
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0018
5304	UPF0166 protein TM_0021	TM_0021	0.0018
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0018
3199	Phosphopantetheine adenylyltransferase	coaD	0.0018
3543	Phosphopantetheine adenylyltransferase	coaD	0.0018
3567	Phosphopantetheine adenylyltransferase	coaD	0.0018
5289	Phosphopantetheine adenylyltransferase	coaD	0.0018
5288	Shikimate kinase	aroK	0.0018
5287	Signaling protein	Not Available	0.0018
5259	Transcriptional regulator	ntrC1	0.0018
6699	Transcriptional regulator	Cgl2612	0.0018
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0018
5293	Shikimate kinase 2	aroL	0.0018
5292	Putative partitioning protein	TT_C1605	0.0017
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0017
5266	Activator of	hgdC	0.0017
5291	Glycogen synthase 1	glgA1	0.0017
2874	Nitrogenase iron protein 1	nifH1	0.0017
4346	Polynucleotide kinase	pseT	0.0017
5264	DNA replication protein	REP	0.0017
5283	D-alanine--D-alanine ligase B	ddlB	0.0017
5281	Plasmid segregation protein parM	parM	0.0017
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0017
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0017
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0017
5299	D-alanine--D-alanine ligase	ddl	0.0017
6598	D-alanine--D-alanine ligase	ddl	0.0017
5284	Large T antigen	Not Available	0.0017
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0017
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0017
5277	Preprotein translocase subunit secA	secA	0.0017
5308	Preprotein translocase secA 1 subunit	secA1	0.0017
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0017
5285	Kinesin heavy chain	KIF5B	0.0017
5315	Chaperone protein htpG	htpG	0.0017
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0017
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0017
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
831	D(2) dopamine receptor	DRD2	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
474	Acetylcholinesterase	ACHE	0.0016
459	Retinoic acid receptor RXR-alpha	RXRA	0.0016
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0015
4106	Guanylate kinase	GUK1	0.0015
4516	Guanylate kinase	gmk	0.0015
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0015
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0015
4774	NTPase P4	Not Available	0.0015
5646	Galactokinase	GALK1	0.0015
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0015
4837	Cag-alfa	cag-alfa	0.0015
5265	FtsH	ftsH	0.0015
4838	PMS1 protein homolog 2	PMS2	0.0015
5302	TrwB	trwB	0.0015
4839	DNA polymerase III subunit tau	dnaX	0.0015
2270	Dephospho-CoA kinase	coaE	0.0015
5189	Trimethylamine dehydrogenase	tmd	0.0015
2284	Adenylate kinase	adk	0.0015
2296	Adenylate kinase	adk	0.0015
2311	Adenylate kinase	adk	0.0015
2312	Adenylate kinase	Not Available	0.0015
3470	Hypothetical protein MG245 homolog	MPN_348	0.0015
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0015
3426	Glutamine synthetase	glnA	0.0015
3987	Glutamine synthetase	GLUL	0.0015
3175	Glutamate--cysteine ligase	gshA	0.0015
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0015
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0014
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0014
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0014
340	Apoptotic protease-activating factor 1	APAF1	0.0014
2683	Mono-ADP-ribosyltransferase C3	C3	0.0014
2390	Nonsecretory ribonuclease	RNASE2	0.0014
5312	Kinesin-like protein KIF1A	KIF1A	0.0014
822	Aldose reductase	AKR1B1	0.0014
2922	Glycerol kinase	glpK	0.0013
5271	Focal adhesion kinase 1	PTK2	0.0013
2282	Protein recA	recA	0.0013
2315	Protein recA	recA	0.0013
2332	Protein recA	recA	0.0013
5263	Protein recA	recA	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
2615	Chemotaxis protein cheA	cheA	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2371	Pantothenate kinase	coaA	0.0013
751	Potassium channel subfamily K member 6	KCNK6	0.0013
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0013
1881	Hexokinase-1	HK1	0.0013
3669	Ribokinase	rbsK	0.0013
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0013
2892	Acetylglutamate kinase	argB	0.0013
3550	Acetylglutamate kinase	argB	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0013
5300	Antigen peptide transporter 1	TAP1	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0012
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
172	Potassium channel subfamily K member 1	KCNK1	0.0012
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0012
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0012
788	Creatine kinase M-type	CKM	0.0012
2334	Dethiobiotin synthetase	bioD	0.0011
6555	Dethiobiotin synthetase	bioD	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0011
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0011
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0011
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0011
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0011
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0011
2251	Thymidylate kinase	tmk	0.001
2254	Thymidylate kinase	DTYMK	0.001
3522	Thymidylate kinase	tmk	0.001
48	Pyridoxal kinase	PDXK	0.001
2091	Endoplasmin	HSP90B1	0.001
1192	Sulfotransferase 1A1	SULT1A1	0.001
70	Type-1 angiotensin II receptor	AGTR1	0.001
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.001
997	Protein kinase C beta type	PRKCB	0.001
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.001
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.001
1422	Serine/threonine-protein kinase 6	AURKA	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
1275	Estrogen sulfotransferase	SULT1E1	0.001
3379	Kinesin-like protein KIF11	KIF11	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.001
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.001
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.001
3822	Actin, alpha skeletal muscle	ACTA1	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1050	Bile salt sulfotransferase	SULT2A1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0009
6102	Arylamine N-acetyltransferase 2	NAT2	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0009
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0009
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0009
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0009
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0008
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0008
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00718 - Adefovir Dipivoxil

Targets

Enzymes

Transporters

Predictions