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Elongation factor 2


Partner ID 6790
Name Elongation factor 2
Synonyms 9026
Gene name EEF2
General function Translation, ribosomal structure and biogenesis
Specific function This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome
Gene sequence + ...

ATGGTTAATTTTACGGTGGATCAGATCCGCGCCATCATGGACAAGAAGGCCAACATCCGCAACATGTCTGTCATCGCCCACGTGGACCATGGCAAGTCCACGCTGACAGACTCCCTGGTGTGCAAGGCGGGCATCATCGCCTCGGCCCGGGCCGGGGAGACACGCTTCACTGATACCCGGAAGGACGAGCAGGAGCGTTGCATCACCATCAAGTCAACTGCCATCTCCCTCTTCTACGAGCTCTCGGAGAATGACTTGAACTTCATCAAGCAGAGCAAGGACGGTGCCGGCTTCCTCATCAACCTCATTGACTCCCCCGGGCATGTCGACTTCTCCTCGGAGGTGACTGCTGCCCTCCGAGTCACCGATGGCGCATTGGTGGTGGTGGACTGCGTGTCAGGCGTGTGCGTGCAGACGGAGACAGTGCTGCGGCAGGCCATTGCCGAGCGCATCAAGCCTGTGCTGATGATGAACAAGATGGACCGCGCCCTGCTGGAGCTGCAGCTGGAGCCCGAGGAGCTCTACCAGACTTTCCAGCGCATCGTGGAGAACGTGAACGTCATCATCTCCACCTACGGCGAGGGCGAGAGCGGCCCCATGGGCAACATCATGATCGATCCTGTCCTCGGTACCGTGGGCTTTGGGTCTGGCCTCCACGGGTGGGCCTTCACCCTGAAGCAGTTTGCCGAGATGTATGTGGCCAAGTTCGCCGCCAAGGGGGAGGGCCAGTTGGGGCCTGCCGAGCGGGCCAAGAAAGTAGAGGACATGATGAAGAAGCTGTGGGGTGACAGGTACTTTGACCCAGCCAACGGCAAGTTCAGCAAGTCAGCCACCAGCCCCGAAGGGAAGAAGCTGCCACGCACCTTCTGCCAGCTGATCCTGGACCCCATCTTCAAGGTGTTTGATGCGATCATGAATTTCAAGAAAGAGGAGACAGCAAAACTGATAGAGAAACTGGACATCAAACTGGACAGCGAGGACAAGGACAAAGAAGGCAAACCCCTGCTGAAGGCTGTGATGCGCCGCTGGCTGCCTGCCGGAGACGCCTTGTTGCAGATGATCACCATCCACCTGCCCTCCCCTGTGACGGCCCAGAAGTACCGCTGCGAGCTCCTGTACGAGGGGCCCCCGGACGACGAGGCTGCCATGGGCATTAAAAGCTGTGACCCCAAAGGCCCTCTTATGATGTATATTTCCAAAATGGTGCCAACCTCCGACAAAGGTCGGTTCTACGCCTTTGGACGAGTCTTCTCGGGGCTGGTCTCCACTGGCCTGAAGGTCAGGATCATGGGGCCCAACTATACCCCTGGGAAGAAGGAGGACCTCTACCTGAAGCCAATCCAGAGAACAATCTTGATGATGGGCCGCTACGTGGAGCCCATCGAGGATGTGCCTTGTGGGAACATTGTGGGCCTCGTGGGCGTGGACCAGTTCCTGGTGAAGACGGGCACCATCACCACCTTCGAGCACGCGCACAACATGCGGGTGATGAAGTTCAGCGTCAGCCCTGTTGTCAGAGTGGCCGTGGAGGCCAAGAACCCGGCTGACCTGCCCAAGCTGGTGGAGGGGCTGAAGCGGCTGGCCAAGTCCGACCCCATGGTGCAGTGCATCATCGAGGAGTCGGGAGAGCATATCATCGCGGGCGCCGGCGAGCTGCACCTGGAGATCTGCCTGAAGGACCTGGAGGAGGACCACGCCTGCATCCCCATCAAGAAATCTGACCCGGTCGTCTCGTACCGCGAGACGGTCAGTGAAGAGTCGAACGTGCTCTGCCTCTCCAAGTCCCCCAACAAGCACAACCGGCTGTACATGAAGGCGCGGCCCTTCCCCGACGGCCTGGCCGAGGACATCGATAAAGGCGAGGTGTCCGCCCGTCAGGAGCTCAAGCAGCGGGCGCGCTACCTGGCCGAGAAGTACGAGTGGGACGTGGCTGAGGCCCGCAAGATCTGGTGCTTTGGGCCCGACGGCACCGGCCCCAACATCCTCACCGACATCACCAAGGGTGTGCAGTACCTCAACGAGATCAAGGACAGTGTGGTGGCCGGCTTCCAGTGGGCCACCAAGGAGGGCGCACTGTGTGAGGAGAACATGCGGGGTGTGCGCTTCGACGTCCACGACGTCACCCTGCACGCCGACGCCATCCACCGCGGAGGGGGCCAGATCATCCCCACAGCACGGCGCTGCCTCTATGCCAGTGTGCTGACCGCCCAGCCACGCCTCATGGAGCCCATCTACCTTGTGGAGATCCAGTGTCCAGAGCAGGTGGTCGGTGGCATCTACGGGGTTTTGAACAGGAAGCGGGGCCACGTGTTCGAGGAGTCCCAGGTGGCCGGCACCCCCATGTTTGTGGTCAAGGCCTATCTGCCCGTCAACGAGTCCTTTGGCTTCACCGCTGACCTGAGGTCCAACACGGGCGGCCAGGCGTTCCCCCAGTGTGTGTTTGACCACTGGCAGATCCTGCCCGGAGACCCCTTCGACAACAGCAGCCGCCCCAGCCAGGTGGTGGCGGAGACCCGCAAGCGCAAGGGCCTGAAAGAAGGCATCCCTGCCCTGGACAACTTCCTGGACAAATTGTAG
Protein sequence + ...

MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
GO Classification
function
GTP binding
binding
nucleotide binding
purine nucleotide binding
guanyl nucleotide binding
process
physiological process
metabolism
macromolecule metabolism
macromolecule biosynthesis
protein biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02059 Adenosine-5-Diphosphoribose
DB03223 Diphthamide
DB04315 Guanosine-5'-Diphosphate
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE

Associated as Prediction

Id Name
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00157 NADH
DB00300 Tenofovir
DB00709 Lamivudine
DB00718 Adefovir Dipivoxil
DB01839 1,2-Propanediol
DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01972 Guanosine-5'-Monophosphate
DB01975 AMPCPR
DB02053 Ribose-5-Phosphate
DB02059 Adenosine-5-Diphosphoribose
DB02109 Hadacidin
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB02210 Hexane-1,6-Diol
DB02212 Pyrophosphate 2-
DB02345 Selenocysteine
DB02362 4-Aminobenzoic Acid
DB02493 Hydantocidin-5'-Phosphate
DB02547 Guanosine-5'-Diphosphate-Rhamnose
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
DB02607 Adenosine Phosphonoacetic Acid
DB02666 (C8-R)-Hydantocidin 5'-Phosphate
DB02682 2-Deamino-6-Deoxy-6thiophosphite-5'-Phosphate Guanosine
DB02701 Nicotinamide
DB02703 Fusidic Acid
DB02750 S-(Methylmercury)-L-Cysteine
DB02774 1,3-Propandiol
DB02836 Guanosine 5'-Diphosphate 2':3'-Cyclic Monophosphate
DB02839 2,4-Dihydroxybenzoic Acid
DB02887 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate
DB02954 (Carboxyhydroxyamino)Ethanoic Acid
DB02975 Ge2270a
DB02994 Hydroxydimethylarsine Oxide
DB03069 Cytidine-5'-Diphospho-Beta-D-Xylose
DB03103 Thymidine-5'- Diphosphate
DB03146 2-Deazo-6-Thiophosphate Guanosine-5'-Monophosphate
DB03147 Flavin-Adenine Dinucleotide
DB03148 Phosphomethylphosphonic Acid Adenosyl Ester
DB03152 B-2-Octylglucoside
DB03223 Diphthamide
DB03226 Trifluoroethanol
DB03431 Adenosine-5'-Diphosphate
DB03478 2'-O-Acetyl Adenosine-5-Diphosphoribose
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB03510 6-O-Phosphoryl Inosine Monophosphate
DB03793 Benzoic Acid
DB03893 Thionicotinamide-Adenine-Dinucleotide
DB04068 Fudp
DB04077 Glycerol
DB04121 Guanosine-3'-Monophosphate-5'-Diphosphate
DB04124 Aurodox
DB04137 Guanosine-5'-Triphosphate
DB04242 P-Hydroxybenzoic Acid
DB04272 Citric Acid
DB04315 Guanosine-5'-Diphosphate
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB04418 Adenylosuccinic Acid
DB04444 Tetrafluoroaluminate Ion
DB04460 (C8-S)-Hydantocidin 5'-Phosphate
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04566 Inosinic Acid
DB04786 Suramin
DB07347 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07677 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
DB07690 (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
DB08058 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one
DB08185 2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08231 MYRISTIC ACID
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
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