DT-Web

DB00128 - L-Aspartic Acid


Identification
Name L-Aspartic Acid
Accession Number DB00128 (EXPT01823, NUTR00016)
Type small molecule
Description One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 133.1027
Groups approved
Monoisotopic Weight 133.037507717
Pharmacology
Indication There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
Mechanism of action There are also claims that L-aspartate has ergogenic effects, that it enhances performance in both prolonged exercise and short intensive exercise. It is hypothesized that L-aspartate, especially the potassium magnesium aspartate salt, spares stores of muscle glycogen and/or promotes a faster rate of glycogen resynthesis during exercise. It has also been hypothesized that L-aspartate can enhance short intensive exercise by serving as a substrate for energy production in the Krebs cycle and for stimulating the purine nucleotide cycle.
Absorption Absorbed from the small intestine by an active transport process
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ribonuclease pancreatic
Name Ribonuclease pancreatic
Gene Name RNASE1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6059
Lysozyme C
Name Lysozyme C
Gene Name LYZ
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Calcium-binding mitochondrial carrier protein Aralar2
Name Calcium-binding mitochondrial carrier protein Aralar2
Gene Name SLC25A13
Pharmacological action unknown
Actions Not Available
References
  • Contreras L, Gomez-Puertas P, Iijima M, Kobayashi K, Saheki T, Satrustegui J: Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. J Biol Chem. 2007 Mar 9;282(10):7098-106. Epub 2007 Jan 9. - Pubmed
  • Saheki T, Iijima M, Li MX, Kobayashi K, Horiuchi M, Ushikai M, Okumura F, Meng XJ, Inoue I, Tajima A, Moriyama M, Eto K, Kadowaki T, Sinasac DS, Tsui LC, Tsuji M, Okano A, Kobayashi T: Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency. J Biol Chem. 2007 Aug 24;282(34):25041-52. Epub 2007 Jun 25. - Pubmed
  • Satrustegui J, Pardo B, Del Arco A: Mitochondrial transporters as novel targets for intracellular calcium signaling. Physiol Rev. 2007 Jan;87(1):29-67. - Pubmed
  • Ikeda S: [Adult-onset citrullinemia] Brain Nerve. 2007 Jan;59(1):59-66. - Pubmed
  • Ikeda S: [Adult-onset citrullinemia] No To Shinkei. 2007 Jan;59(1):59-66. - Pubmed
DTHybrid score 1.0759
Aspartate aminotransferase, cytoplasmic
Name Aspartate aminotransferase, cytoplasmic
Gene Name GOT1
Pharmacological action unknown
Actions Not Available
References
  • Tordjman J, Leroyer S, Chauvet G, Quette J, Chauvet C, Tomkiewicz C, Chapron C, Barouki R, Forest C, Aggerbeck M, Antoine B: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. J Biol Chem. 2007 Aug 10;282(32):23591-602. Epub 2007 Jun 1. - Pubmed
  • Girgin S, Gedik E, Tacyildiz IH, Akgun Y, Bac B, Uysal E: Factors affecting morbidity and mortality in gangrenous cholecystitis. Acta Chir Belg. 2006 Sep-Oct;106(5):545-9. - Pubmed
  • Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R: Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. J Neurochem. 2007 Jul;102(1):103-11. Epub 2007 Apr 17. - Pubmed
  • Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H: Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):115-20. - Pubmed
  • Zappacosta B, Manni A, Persichilli S, Boari A, Scribano D, Minucci A, Raffaelli L, Giardina B, De Sole P: Salivary thiols and enzyme markers of cell damage in periodontal disease. Clin Biochem. 2007 Jun;40(9-10):661-5. Epub 2007 Jan 26. - Pubmed
DTHybrid score 0.7341
Mitochondrial aspartate-glutamate carrier protein
Name Mitochondrial aspartate-glutamate carrier protein
Gene Name SLC25A13
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Lu YB, Kobayashi K, Ushikai M, Tabata A, Iijima M, Li MX, Lei L, Kawabe K, Taura S, Yang Y, Liu TT, Chiang SH, Hsiao KJ, Lau YL, Tsui LC, Lee DH, Saheki T: Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency. J Hum Genet. 2005;50(7):338-46. Epub 2005 Jul 30. - Pubmed
  • Moriyama M, Li MX, Kobayashi K, Sinasac DS, Kannan Y, Iijima M, Horiuchi M, Tsui LC, Tanaka M, Nakamura Y, Saheki T: Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice. J Hepatol. 2006 May;44(5):930-8. Epub 2005 Nov 8. - Pubmed
  • Begum L, Jalil MA, Kobayashi K, Iijima M, Li MX, Yasuda T, Horiuchi M, del Arco A, Satrustegui J, Saheki T: Expression of three mitochondrial solute carriers, citrin, aralar1 and ornithine transporter, in relation to urea cycle in mice. Biochim Biophys Acta. 2002 Apr 12;1574(3):283-92. - Pubmed
DTHybrid score 1.076
Aspartoacylase
Name Aspartoacylase
Gene Name ASPA
Pharmacological action unknown
Actions Not Available
References
  • Wang J, Matalon R, Bhatia G, Wu G, Li H, Liu T, Lu ZH, Ledeen RW: Bimodal occurrence of aspartoacylase in myelin and cytosol of brain. J Neurochem. 2007 Apr;101(2):448-57. Epub 2007 Jan 24. - Pubmed
  • Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN Jr: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):456-61. Epub 2006 Dec 28. - Pubmed
  • Janson CG, McPhee SW, Francis J, Shera D, Assadi M, Freese A, Hurh P, Haselgrove J, Wang DJ, Bilaniuk L, Leone P: Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI. Neuropediatrics. 2006 Aug;37(4):209-21. - Pubmed
  • Srikanth SG, Chandrashekar HS, Nagarajan K, Jayakumar PN: Restricted diffusion in Canavan disease. Childs Nerv Syst. 2007 Apr;23(4):465-8. Epub 2007 Jan 12. - Pubmed
  • Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM: N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol. 2007 Feb;81(2):89-131. Epub 2007 Jan 5. - Pubmed
DTHybrid score 1.0587
Asparagine synthetase [glutamine-hydrolyzing]
Name Asparagine synthetase [glutamine-hydrolyzing]
Gene Name ASNS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8152
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Flam BR, Eichler DC, Solomonson LP: Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle. Nitric Oxide. 2007 Nov-Dec;17(3-4):115-21. Epub 2007 Aug 3. - Pubmed
  • Ben-Yoseph Y, Mitchell DA: Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts. Clin Chim Acta. 1989 Aug 15;183(2):125-33. - Pubmed
  • Shen LJ, Beloussow K, Shen WC: Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem Pharmacol. 2005 Jan 1;69(1):97-104. - Pubmed
DTHybrid score 0.7793
Aminoacylase-1
Name Aminoacylase-1
Gene Name ACY1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Mitta M, Ohnogi H, Yamamoto A, Kato I, Sakiyama F, Tsunasawa S: The primary structure of porcine aminoacylase 1 deduced from cDNA sequence. J Biochem (Tokyo). 1992 Dec;112(6):737-42. - Pubmed
DTHybrid score 1.0583
Aspartate aminotransferase, mitochondrial
Name Aspartate aminotransferase, mitochondrial
Gene Name GOT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Collier RH, Kohlhaw G: Nonidentity of the aspartate and the aromatic aminotransferase components of transaminase A in Escherichia coli. J Bacteriol. 1972 Oct;112(1):365-71. - Pubmed
  • Grell EH: Genetic analysis of aspartate aminotransferase isozymes from hybrids between Drosophila melanogaster and Drosophila simulans and mutagen-induced isozyme variants. Genetics. 1976 Aug;83(4):753-64. - Pubmed
  • Recasens M, Mandel P: Similarities between cysteinesulphinate transaminase and aspartate aminotransferase. Ciba Found Symp. 1979;(72):259-70. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8584
Aspartyl-tRNA synthetase, cytoplasmic
Name Aspartyl-tRNA synthetase, cytoplasmic
Gene Name DARS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Eiler S, Dock-Bregeon A, Moulinier L, Thierry JC, Moras D: Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step. EMBO J. 1999 Nov 15;18(22):6532-41. - Pubmed
  • Fender A, Sauter C, Messmer M, Putz J, Giege R, Florentz C, Sissler M: Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system. J Biol Chem. 2006 Jun 9;281(23):15980-6. Epub 2006 Apr 5. - Pubmed
  • Cavarelli J, Eriani G, Rees B, Ruff M, Boeglin M, Mitschler A, Martin F, Gangloff J, Thierry JC, Moras D: The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J. 1994 Jan 15;13(2):327-37. - Pubmed
DTHybrid score 1.0581
Calcium-binding mitochondrial carrier protein Aralar1
Name Calcium-binding mitochondrial carrier protein Aralar1
Gene Name SLC25A12
Pharmacological action unknown
Actions Not Available
References
  • Correia C, Coutinho AM, Diogo L, Grazina M, Marques C, Miguel T, Ataide A, Almeida J, Borges L, Oliveira C, Oliveira G, Vicente AM: Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. J Autism Dev Disord. 2006 Nov;36(8):1137-40. - Pubmed
  • Contreras L, Gomez-Puertas P, Iijima M, Kobayashi K, Saheki T, Satrustegui J: Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. J Biol Chem. 2007 Mar 9;282(10):7098-106. Epub 2007 Jan 9. - Pubmed
  • Satrustegui J, Contreras L, Ramos M, Marmol P, Del Arco A, Saheki T, Pardo B: Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria. J Neurosci Res. 2007 May 11;. - Pubmed
  • Satrustegui J, Pardo B, Del Arco A: Mitochondrial transporters as novel targets for intracellular calcium signaling. Physiol Rev. 2007 Jan;87(1):29-67. - Pubmed
DTHybrid score 1.0693
Aspartyl/asparaginyl beta-hydroxylase
Name Aspartyl/asparaginyl beta-hydroxylase
Gene Name ASPH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Whiteman P, Marks C, Freese E: The sodium effect of Bacillus subtilis growth on aspartate. J Gen Microbiol. 1980 Aug;119(2):493-504. - Pubmed
  • Iijima T, Diesterhaft MD, Freese E: Sodium effect of growth on aspartate and genetic analysis of a Bacillus subtilis mutant with high aspartase activity. J Bacteriol. 1977 Mar;129(3):1440-7. - Pubmed
DTHybrid score 0.9275
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase
Name Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase
Gene Name PAICS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0583
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase
Name CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase
Gene Name CAD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0598
Adenylosuccinate synthetase isozyme 2
Name Adenylosuccinate synthetase isozyme 2
Gene Name ADSS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Raman J, Mehrotra S, Anand RP, Balaram H: Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase. Mol Biochem Parasitol. 2004 Nov;138(1):1-8. - Pubmed
  • Mehrotra S, Balaram H: Kinetic Characterization of Adenylosuccinate Synthetase from the Thermophilic Archaea Methanocaldococcus jannaschii. Biochemistry. 2007 Oct 11;. - Pubmed
  • Datta SK, Guicherit OM, Kellems RE: Adenylosuccinate synthetase: a dominant amplifiable genetic marker in mammalian cells. Somat Cell Mol Genet. 1994 Sep;20(5):381-9. - Pubmed
DTHybrid score 1.0647
Excitatory amino acid transporter 3
Name Excitatory amino acid transporter 3
Gene Name SLC1A1
Pharmacological action unknown
Actions Not Available
References
  • Tao Z, Grewer C: Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1. J Gen Physiol. 2007 Apr;129(4):331-44. - Pubmed
  • Teichman S, Kanner BI: Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter. J Gen Physiol. 2007 Jun;129(6):527-39. - Pubmed
  • Tai YH, Wang YH, Tsai RY, Wang JJ, Tao PL, Liu TM, Wang YC, Wong CS: Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats. Pain. 2007 Jun;129(3):343-54. Epub 2007 Mar 7. - Pubmed
  • Ozawa S: [Role of glutamate transporters in excitatory synapses in cerebellar Purkinje cells] Brain Nerve. 2007 Jul;59(7):669-76. - Pubmed
DTHybrid score 1.025
Growth-inhibiting protein 18
Name Growth-inhibiting protein 18
Gene Name GIG18
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7317
Adenylosuccinate synthetase
Name Adenylosuccinate synthetase
Gene Name ADSS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ladino C, Schneeberger EE, Rabito CA, Lynch RD: Reduction of adenine nucleotide content of clone 4 MDCK cells: effects on multiplication, protein synthesis, and morphology. J Cell Physiol. 1989 Jul;140(1):186-94. - Pubmed
  • Jahngen EG, Rossomando EF: Adenylosuccinate synthetase from Dictyostelium discoideum: effects of hadacidin analogs and binding of [14C]hadacidin. Arch Biochem Biophys. 1984 Feb 15;229(1):145-54. - Pubmed
  • Ladino C, Schneeberger EE, Rabito CA, Lynch RD: Inhibition of adenine nucleotide synthesis: effect on tight junction structure and function of clone 4 MDCK cells. Eur J Cell Biol. 1991 Aug;55(2):217-24. - Pubmed
DTHybrid score 0.1051
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Flam BR, Eichler DC, Solomonson LP: Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle. Nitric Oxide. 2007 Nov-Dec;17(3-4):115-21. Epub 2007 Aug 3. - Pubmed
  • Ben-Yoseph Y, Mitchell DA: Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts. Clin Chim Acta. 1989 Aug 15;183(2):125-33. - Pubmed
  • Shen LJ, Beloussow K, Shen WC: Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem Pharmacol. 2005 Jan 1;69(1):97-104. - Pubmed
DTHybrid score 0.7793
Aspartyl-tRNA synthetase, mitochondrial
Name Aspartyl-tRNA synthetase, mitochondrial
Gene Name DARS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Eiler S, Dock-Bregeon A, Moulinier L, Thierry JC, Moras D: Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step. EMBO J. 1999 Nov 15;18(22):6532-41. - Pubmed
  • Fender A, Sauter C, Messmer M, Putz J, Giege R, Florentz C, Sissler M: Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system. J Biol Chem. 2006 Jun 9;281(23):15980-6. Epub 2006 Apr 5. - Pubmed
  • Cavarelli J, Eriani G, Rees B, Ruff M, Boeglin M, Mitschler A, Martin F, Gangloff J, Thierry JC, Moras D: The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J. 1994 Jan 15;13(2):327-37. - Pubmed
DTHybrid score 1.0581
ASRGL1 protein
Name ASRGL1 protein
Gene Name ASRGL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0138
Adenylosuccinate synthetase isozyme 1
Name Adenylosuccinate synthetase isozyme 1
Gene Name ADSSL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0571
Aspartoacylase-2
Name Aspartoacylase-2
Gene Name ACY3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0588

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.8423

Predictions


Id Partner name Gene Name Score
2680 Argininosuccinate synthase argG 0.7793
3194 Argininosuccinate synthase argG 0.7793
3516 Aspartate carbamoyltransferase catalytic chain pyrB 0.2939
2746 4-aminobutyrate aminotransferase gabT 0.1894
263 Neutral amino acid transporter B(0) SLC1A5 0.1884
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.1869
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.1869
314 System N amino acid transporter 1 SLC38A3 0.1802
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.1761
2632 Adenylosuccinate synthetase purA 0.1051
3323 Adenylosuccinate synthetase purA 0.1051
4598 Adenylosuccinate synthetase Adss 0.1051
6817 Adenylosuccinate synthetase purA 0.1051
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0993
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0993
4066 Protein-arginine deiminase type-1 PADI1 0.0993
4067 Protein-arginine deiminase type-3 PADI3 0.0993
4068 Protein-arginine deiminase type-2 PADI2 0.0993
4065 Protein-arginine deiminase type-6 PADI6 0.0993
1814 Protein-arginine deiminase type-4 PADI4 0.0764
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0688
917 Glutaminase kidney isoform, mitochondrial GLS 0.0613
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0613
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0613
5 Glutaminase liver isoform, mitochondrial GLS2 0.0613
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0613
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0613
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0613
5261 Phosphoribosylformylglycinamidine synthase purL 0.0613
3511 Ribonuclease 4 RNASE4 0.0579
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0576
7 Nitric oxide synthase, inducible NOS2 0.0541
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0537
291 Nitric-oxide synthase, endothelial NOS3 0.0533
763 Tyrosine aminotransferase TAT 0.052
5493 Tyrosine aminotransferase Not Available 0.052
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0497
2823 Trypanothione reductase TPR 0.0494
499 Arginine decarboxylase ADC 0.048
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0462
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0456
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
2537 Aromatic-amino-acid aminotransferase tyrB 0.0434
76 Nitric-oxide synthase, brain NOS1 0.0432
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0431
2249 Aspartate aminotransferase aspC 0.043
2671 Aspartate aminotransferase aspC 0.043
5490 Aspartate aminotransferase Not Available 0.043
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0427
150 Cationic amino acid transporter 3 SLC7A3 0.0427
58 Cationic amino acid transporter 4 SLC7A4 0.0427
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0424
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0424
665 Phosphoserine aminotransferase PSAT1 0.0424
4652 Phosphoserine aminotransferase serC 0.0424
420 Glutamate decarboxylase 1 GAD1 0.0424
3900 Glutamate decarboxylase 1 GAD1 0.0424
3799 Hypoxanthine phosphoribosyltransferase hpt 0.0422
3719 Inosine-5'-monophosphate dehydrogenase guaB 0.0422
358 Cystathionine beta-synthase CBS 0.0414
1566 Corticoliberin CRH 0.0413
169 Cysteine desulfurase, mitochondrial NFS1 0.0408
2390 Nonsecretory ribonuclease RNASE2 0.0405
735 Alanine aminotransferase 1 GPT 0.0396
3904 Alanine aminotransferase 2 GPT2 0.0396
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0394
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0392
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0392
1008 CTP synthase 1 CTPS 0.0392
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0392
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0392
3989 Glutaminyl-tRNA synthetase QARS 0.0392
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0392
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0392
89 Cysteine sulfinic acid decarboxylase CSAD 0.039
2636 Shikimate dehydrogenase aroE 0.0384
3515 Shikimate dehydrogenase aroE 0.0384
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0372
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0365
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.036
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0353
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0351
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0351
4007 Succinate receptor 1 SUCNR1 0.0351
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0351
1410 Oxidoreductase HSD17B6 0.0351
4725 Oxidoreductase Not Available 0.0351
5124 Oxidoreductase Not Available 0.0351
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0351
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0351
498 Solute carrier family 13 member 2 SLC13A2 0.0351
25 Solute carrier family 13 member 1 SLC13A1 0.0351
673 Solute carrier family 13 member 3 SLC13A3 0.0351
1912 Excitatory amino acid transporter 1 SLC1A3 0.0334
4016 Excitatory amino acid transporter 5 SLC1A7 0.0334
4019 Excitatory amino acid transporter 4 SLC1A6 0.0334
1047 Excitatory amino acid transporter 2 SLC1A2 0.0333
834 Arginase-2, mitochondrial ARG2 0.0333
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0332
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0332
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0332
4026 Aspartyl aminopeptidase DNPEP 0.0332
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0332
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0332
664 Glutamate decarboxylase 2 GAD2 0.0332
3890 Glutamate decarboxylase 2 GAD2 0.0332
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0332
922 Glutamate receptor 4 GRIA4 0.0332
4020 Glutamyl aminopeptidase ENPEP 0.0332
4018 Glutamate receptor delta-2 subunit GRID2 0.0332
926 Metabotropic glutamate receptor 7 GRM7 0.0332
4027 Glutamate receptor delta-1 subunit GRID1 0.0332
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0332
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0332
927 Metabotropic glutamate receptor 8 GRM8 0.0332
925 Metabotropic glutamate receptor 4 GRM4 0.0332
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0332
4017 5-oxoprolinase OPLAH 0.0332
868 Cystathionine gamma-lyase CTH 0.0327
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0324
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0316
577 Argininosuccinate lyase ASL 0.0311
534 Threonine synthase-like 1 THNSL1 0.0304
6 Coagulation factor XIII A chain F13A1 0.0301
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0299
413 Amidophosphoribosyltransferase PPAT 0.0298
2515 Amidophosphoribosyltransferase purF 0.0298
3714 Amidophosphoribosyltransferase purF 0.0298
171 Cysteine dioxygenase CDO-1 0.0295
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0295
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0295
1314 Thiamine transporter 2 SLC19A3 0.0294
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0287
3354 Ras-related protein Rap-2a RAP2A 0.0286
3335 Probable GTP-binding protein engB engB 0.0285
2532 Pantoate--beta-alanine ligase panC 0.0285
1123 Eosinophil cationic protein RNASE3 0.0285
33 Cystine/glutamate transporter SLC7A11 0.0281
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0271
3 Histidine decarboxylase HDC 0.0266
1152 Glycogen phosphorylase, muscle form PYGM 0.0265
833 Organic cation/carnitine transporter 1 SLC22A4 0.0262
365 Dihydrofolate reductase DHFR 0.026
2381 Dihydrofolate reductase DFR1 0.026
2833 Dihydrofolate reductase Not Available 0.026
2931 Dihydrofolate reductase folA 0.026
3544 Dihydrofolate reductase folA 0.026
3682 Dihydrofolate reductase folA 0.026
6642 Dihydrofolate reductase folA 0.026
6756 Dihydrofolate reductase dfrA 0.026
199 Monocarboxylate transporter 8 SLC16A2 0.0258
625 Glutamate carboxypeptidase 2 FOLH1 0.0257
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0254
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0253
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0249
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0249
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0249
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0248
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0247
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0247
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0247
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0247
6645 D-amino-acid oxidase DAO 0.0245
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.024
916 Metabotropic glutamate receptor 1 GRM1 0.0239
1758 GTPase HRas HRAS 0.0238
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0237
349 Serine--pyruvate aminotransferase AGXT 0.0233
5925 Neuropeptide Y NPY 0.0231
340 Apoptotic protease-activating factor 1 APAF1 0.023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.023
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.023
431 Serine racemase SRR 0.0229
184 L-serine dehydratase SDS 0.0229
491 Serine palmitoyltransferase 1 SPTLC1 0.0229
727 Serine palmitoyltransferase 2 SPTLC2 0.0228
923 Glutamate receptor 3 GRIA3 0.0228
626 Cysteine dioxygenase type 1 CDO1 0.0227
1673 GTP cyclohydrolase I GCH1 0.0225
3302 GTP cyclohydrolase I folE 0.0225
3209 Ornithine decarboxylase, inducible odcI 0.0225
207 Glutathione synthetase GSS 0.0225
5269 Glutathione synthetase gshB 0.0225
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0224
738 Monocarboxylate transporter 1 SLC16A1 0.0224
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0223
6316 ADP-ribosylation factor 1 ARF1 0.0223
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0222
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0219
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0215
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0215
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0215
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0209
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0209
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0208
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0207
825 Arsenical pump-driving ATPase ASNA1 0.0207
3435 Arsenical pump-driving ATPase arsA 0.0207
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0207
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0207
733 Activin receptor type 1B ACVR1B 0.0207
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0207
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0207
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0207
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0207
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0207
154 AFG3-like protein 2 AFG3L2 0.0207
395 ALK tyrosine kinase receptor Not Available 0.0207
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0198
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0198
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0196
3311 mRNA-capping enzyme A103R 0.0196
2647 RNA-directed RNA polymerase P2 0.0196
246 Valyl-tRNA synthetase VARS 0.0196
705 Glutamate receptor 1 GRIA1 0.0194
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.0188
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0188
118 Organic cation/carnitine transporter 2 SLC22A5 0.0185
435 Kynureninase KYNU 0.0182
4654 Kynureninase kynU 0.0182
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0177
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0177
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0177
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0177
297 Adenylate cyclase type 1 ADCY1 0.0177
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0175
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0174
3881 Selenocysteine lyase variant Not Available 0.0174
3887 Phosphorylase PYGB 0.0174
3911 Uncharacterized protein C20orf38 SPTLC3 0.0174
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0174
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0174
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0174
3906 Serine dehydratase-like SDSL 0.0174
306 Pyridoxal phosphate phosphatase PDXP 0.0174
3891 Putative L-Dopa decarboxylase DDC 0.0174
3880 Serine hydroxymethyltransferase 1 Not Available 0.0174
3893 DDC protein DDC 0.0174
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0174
3883 Ornithine aminotransferase variant Not Available 0.0174
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0174
3886 Migration-inducing protein 4 ALAS1 0.0174
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0174
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0174
3878 GAD1 protein GAD1 0.0174
3882 Brain glycogen phosphorylase variant Not Available 0.0174
3905 Molybdenum cofactor sulfurase MOCOS 0.0174
3894 KIAA0251 protein PDXDC1 0.0174
3875 Glycogen phosphorylase, brain form PYGB 0.0174
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0173
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.017
292 Activin receptor type-1 ACVR1 0.017
849 Activated CDC42 kinase 1 TNK2 0.0169
5469 Head decoration protein shp 0.0168
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0165
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0164
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0164
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.0163
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0161
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0161
2457 Bacillolysin nprS 0.016
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0158
6142 Solute carrier family 22 member 8 SLC22A8 0.0158
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
2795 Methionine aminopeptidase 2 METAP2 0.0156
484 Tyrosine-protein kinase ABL2 ABL2 0.0153
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0152
676 Tyrosine 3-monooxygenase TH 0.0149
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0148
3879 Serine hydroxymethyltransferase 2 Not Available 0.0148
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0148
3884 SHMT2 protein SHMT2 0.0148
3901 SHMT2 protein SHMT2 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0146
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0145
3913 Glutamic acid decarboxylase GAD65 0.0141
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
2314 Triosephosphate isomerase TPI 0.014
3417 Triosephosphate isomerase tpiA 0.014
3443 Triosephosphate isomerase tpiA 0.014
6346 Triosephosphate isomerase TPI1 0.014
6021 Adenosine kinase ADK 0.0136
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0135
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
921 Glutamate receptor 2 GRIA2 0.0133
472 Ornithine aminotransferase, mitochondrial OAT 0.0132
661 ADP/ATP translocase 1 SLC25A4 0.0132
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0128
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0127
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
2297 Genome polyprotein Not Available 0.0118
2322 Genome polyprotein Not Available 0.0118
2694 Genome polyprotein Not Available 0.0118
2719 Genome polyprotein Not Available 0.0118
2860 Genome polyprotein Not Available 0.0118
2928 Genome polyprotein Not Available 0.0118
3160 Genome polyprotein Not Available 0.0118
3260 Genome polyprotein Not Available 0.0118
4783 Genome polyprotein Not Available 0.0118
5726 Genome polyprotein Not Available 0.0118
5779 Genome polyprotein Not Available 0.0118
5867 Genome polyprotein Not Available 0.0118
6253 Genome polyprotein Not Available 0.0118
6301 Genome polyprotein Not Available 0.0118
6380 Genome polyprotein Not Available 0.0118
6381 Genome polyprotein Not Available 0.0118
6437 Genome polyprotein Not Available 0.0118
6520 Genome polyprotein Not Available 0.0118
6521 Genome polyprotein Not Available 0.0118
6652 Genome polyprotein Not Available 0.0118
6734 Genome polyprotein Not Available 0.0118
6735 Genome polyprotein Not Available 0.0118
6736 Genome polyprotein Not Available 0.0118
6737 Genome polyprotein Not Available 0.0118
6738 Genome polyprotein Not Available 0.0118
6739 Genome polyprotein Not Available 0.0118
6744 Genome polyprotein Not Available 0.0118
6748 Genome polyprotein Not Available 0.0118
6894 Genome polyprotein Not Available 0.0118
6898 Genome polyprotein Not Available 0.0118
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0114
449 Ornithine decarboxylase ODC1 0.0111
3261 Signal recognition particle protein ffh 0.011
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0105
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0105
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0105
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.0104
3197 GDP-mannose mannosyl hydrolase nudD 0.0103
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0102
5618 ADP-ribosylation factor 4 ARF4 0.0102
5628 Probable GTPase engC rsgA 0.0102
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0102
2170 Transforming protein RhoA RHOA 0.0102
3366 GTP-binding protein engA der 0.0102
5627 GDP-mannose 4,6-dehydratase gca 0.0102
5624 GTPase rab6 0.0102
5650 NimA-related protein DR_0842 0.0101
500 Monocarboxylate transporter 4 SLC16A3 0.01
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
2521 Cell division protein ftsZ ftsZ 0.0098
3301 Cell division protein ftsZ ftsZ 0.0098
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
10 Glycogen phosphorylase, liver form PYGL 0.0097
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
465 Calmodulin CALM1 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
776 Bile salt export pump ABCB11 0.0091
3115 Ras-related protein Rab-9 RAB9A 0.009
3270 Elongation factor G fusA 0.0089
3170 Elongation factor Tu-B tufB 0.0089
3396 Elongation factor Tu tufA 0.0089
5621 Elongation factor Tu tuf 0.0089
5619 GDP-mannose 4,6 dehydratase GMDS 0.0089
3107 Putative GTP pyrophosphokinase relA 0.0089
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0089
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
489 Monocarboxylate transporter 2 SLC16A7 0.0086
1588 Multidrug resistance protein 1 ABCB1 0.0084
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0083
6750 ADP-ribosylation factor 6 ARF6 0.0083
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0082
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0079
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
6790 Elongation factor 2 EEF2 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
1353 DNA topoisomerase 1 TOP1 0.0077
3552 DNA topoisomerase 1 topA 0.0077
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
2452 Tryptophanyl-tRNA synthetase trpS 0.0069
1050 Bile salt sulfotransferase SULT2A1 0.0069
594 Thyroxine-binding globulin SERPINA7 0.0066
1192 Sulfotransferase 1A1 SULT1A1 0.0065
1275 Estrogen sulfotransferase SULT1E1 0.0065
5294 Nucleoside diphosphate kinase A NME1 0.0062
5626 Nucleoside diphosphate kinase B NME2 0.0061
5126 Arginase rocF 0.0061
758 Thyroid hormone receptor alpha THRA 0.0061
624 Guanidinoacetate N-methyltransferase GAMT 0.006
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0052
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0048
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
2300 Lysozyme E 0.0048
3633 Lysozyme R 0.0048
5597 Lysozyme 17 0.0048
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0048
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0043
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
4533 Glyoxalase family protein BC_1747 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
3175 Glutamate--cysteine ligase gshA 0.0034
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0034
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
3583 6-phosphogluconolactonase pgl 0.0033
6147 Solute carrier family 22 member 3 SLC22A3 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
432 D(4) dopamine receptor DRD4 0.003
3027 Streptavidin Not Available 0.003
587 Serum albumin ALB 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
638 D(3) dopamine receptor DRD3 0.0029
6144 Solute carrier family 22 member 2 SLC22A2 0.0029
6145 Solute carrier family 22 member 1 SLC22A1 0.0029
6423 Light-harvesting protein B-800/820 alpha chain Not Available 0.0028
6589 Delta-hemolysin hld 0.0028
6586 Protein S100-G S100G 0.0028
6591 ATP synthase C chain atpH 0.0028
6424 Light-harvesting protein B-800/820 beta chain Not Available 0.0028
6587 Rubredoxin rub 0.0028
6592 Probable L-ascorbate-6-phosphate lactonase ulaG ulaG 0.0028
6585 HLA class I histocompatibility antigen, B-27 alpha chain HLA-B 0.0028
4718 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP 0.0028
6588 Methionyl-tRNA formyltransferase fmt 0.0028
6593 Immunoglobulin G-binding protein G spg 0.0028
411 Glycine N-methyltransferase GNMT 0.0027
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
23 D(1A) dopamine receptor DRD1 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0025
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0025
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6279 Beta-2-microglobulin B2M 0.0025
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6319 Respiratory nitrate reductase 1 gamma chain narI 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
6318 Respiratory nitrate reductase 1 beta chain narH 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
6317 Respiratory nitrate reductase 1 alpha chain narG 0.0024
831 D(2) dopamine receptor DRD2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
4037 Hypothetical protein GPX1 0.0024
4297 Hypothetical protein SP_1951 0.0024
4521 Hypothetical protein BC_2969 0.0024
4540 Hypothetical protein TM_1070 0.0024
4555 Hypothetical protein MT1739 0.0024
4569 Hypothetical protein mshD 0.0024
4578 Hypothetical protein PA3270 0.0024
4747 Hypothetical protein PA3967 0.0024
5177 Hypothetical protein TM_0096 0.0024
5194 Hypothetical protein PA1204 0.0024
5240 Hypothetical protein Rv2991 0.0024
5370 Hypothetical protein TM_1158 0.0024
5710 Hypothetical protein Tb927.5.1360 0.0024
4522 Arginine N-succinyltransferase subunit alpha astA 0.0024
4538 Hypothetical protein VC1899 VC_1899 0.0024
4529 Oxalate decarboxylase oxdC oxdC 0.0024
4527 Putative hydrolase ycdX ycdX 0.0024
4536 Transcriptional regulator, IclR family TM_0065 0.0024
2501 Protein ygbM ygbM 0.0024
4514 Citrate lyase beta subunit-like protein citE 0.0024
4781 Citrate lyase beta subunit-like protein DR_1240 0.0024
4524 Mannose-6-phosphate isomerase yvyI 0.0024
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0024
4545 Molybdopterin-converting factor subunit 2 moaE 0.0024
4547 Iron binding protein FbpA fbpA 0.0024
4548 Gyrase B gyrB 0.0024
4546 Aminotransferase, putative TM_1131 0.0024
658 Para-aminobenzoate synthase component 1 pabB 0.0024
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0024
4515 Peripheral plasma membrane protein CASK CASK 0.0024
766 Beta-2 adrenergic receptor ADRB2 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0023
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0023
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0023
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.0021
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.0021
4496 C-terminal-binding protein 1 CTBP1 0.0021
2929 (S)-2-haloacid dehalogenase dhlB 0.0021
2995 (S)-2-haloacid dehalogenase Not Available 0.0021
4532 Gephyrin GPHN 0.0021
4528 Phenazine biosynthesis protein PhzD phzD1 0.0021
4542 Glutaminase 1 glsA1 0.0021
4544 Glutaminase 1 glsA1 0.0021
3237 Beta-lactamase OXA-2 bla 0.0021
56 Delta-aminolevulinic acid dehydratase ALAD 0.0021
2356 Delta-aminolevulinic acid dehydratase hemB 0.0021
3613 Delta-aminolevulinic acid dehydratase hemB 0.0021
3674 Delta-aminolevulinic acid dehydratase hemB 0.0021
3759 Glutathione S-transferase gst 0.0021
4541 Glutathione S-transferase GST 0.0021
4517 Probable butyrate kinase 2 buk2 0.002
556 Alpha-1A adrenergic receptor ADRA1A 0.002
2697 Uridine-cytidine kinase 2 UCK2 0.002
2230 Catalase CAT 0.0019
3249 Catalase katA 0.0019
3625 Catalase katA 0.0019
4539 Catalase katA 0.0019
4941 Catalase katB 0.0019
2132 Protein S100-B S100B 0.0019
3467 Methylglyoxal synthase mgsA 0.0019
2775 Dihydroorotate dehydrogenase pyrD 0.0019
4531 Putative ketoacyl reductase actIII 0.0019
6352 Reaction center protein H chain puhA 0.0019
6456 Reaction center protein H chain puhA 0.0019
6682 Reaction center protein H chain puhA 0.0019
6354 Reaction center protein M chain pufM 0.0019
6455 Reaction center protein M chain pufM 0.0019
6684 Reaction center protein M chain pufM 0.0019
6353 Reaction center protein L chain pufL 0.0019
6454 Reaction center protein L chain pufL 0.0019
6683 Reaction center protein L chain pufL 0.0019
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0019
4119 Cytochrome P450 2D6 CYP2D6 0.0018
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0018
2838 Ribose-5-phosphate isomerase A rpiA 0.0018
2952 Ribose-5-phosphate isomerase A rpiA 0.0018
5595 Ribose-5-phosphate isomerase A rpiA 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
5590 N utilization substance protein B homolog nusB 0.0018
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0018
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0018
5591 Complement component C8 gamma chain C8G 0.0018
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0018
5582 Regulator of transcription; stringent starvation protein A sspA 0.0018
5593 Transferase Not Available 0.0018
4695 UPF0124 protein yfiH yfiH 0.0018
5060 Intron-associated endonuclease 1 ITEVIR 0.0018
5588 Cell division protein FtsY TM_0570 0.0018
5575 Short tail fiber protein 12 0.0018
5600 Pyruvate decarboxylase pdc 0.0018
5587 Iron(III)-binding periplasmic protein fbpA 0.0018
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0018
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0018
5581 Beta-fructosidase bfrA 0.0018
4375 Glutamine synthetase 1 glnA1 0.0018
5580 Hexon protein PII 0.0018
5574 Invasin YPTB1668 0.0018
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0018
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
2688 Peptide deformylase def 0.0017
2708 Peptide deformylase def 0.0017
3004 Peptide deformylase def 0.0017
4337 Peptide deformylase def 0.0017
4338 Peptide deformylase def 0.0017
5368 Peptide deformylase def 0.0017
5371 Peptide deformylase def 0.0017
6375 Peptide deformylase def 0.0017
6378 Peptide deformylase def 0.0017
6379 Peptide deformylase def 0.0017
6776 Peptide deformylase def 0.0017
6900 Peptide deformylase def 0.0017
4534 Cytohesin-2 CYTH2 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
2548 Subtilisin Carlsberg apr 0.0016
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0016
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0016
4992 Cytochrome c peroxidase Not Available 0.0016
5006 RNASE4 protein RNASE4 0.0016
2555 Pol polyprotein pol 0.0016
3242 Pol polyprotein gag-pol 0.0016
3471 Pol polyprotein gag-pro-pol 0.0016
5256 Pol polyprotein pol 0.0016
6469 Pol polyprotein gag-pol 0.0016
6565 Pol polyprotein Not Available 0.0016
3132 Tryptophan synthase alpha chain trpA 0.0016
6568 Tryptophan synthase alpha chain trpA 0.0016
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0016
3729 Citrate synthase gltA 0.0016
4575 Citrate synthase cit 0.0016
4580 Citrate synthase gltA 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
309 Antithrombin-III SERPINC1 0.0015
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0015
2149 Angiogenin ANG 0.0015
2603 Beta-lactamase II blm 0.0015
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
810 Heme oxygenase 1 HMOX1 0.0014
3391 Heme oxygenase 1 pbsA1 0.0014
3486 Fumarate hydratase class II fumC 0.0014
2286 Isocitrate dehydrogenase [NADP] icd 0.0014
2302 Isocitrate dehydrogenase [NADP] icd 0.0014
2771 Isocitrate dehydrogenase [NADP] icd 0.0014
2942 Sialidase nanH 0.0014
3546 Sialidase nedA 0.0014
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
857 Malate dehydrogenase, mitochondrial MDH2 0.0014
4924 Cytochrome P450 2C8 CYP2C8 0.0013
332 Beta-lactamase blaZ 0.0013
2478 Beta-lactamase ampC 0.0013
2613 Beta-lactamase ampC 0.0013
2635 Beta-lactamase ampC 0.0013
2700 Beta-lactamase penP 0.0013
5445 Beta-lactamase blaB 0.0013
6019 Beta-lactamase SHV-7 0.0013
6701 Beta-lactamase cphA 0.0013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0013
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0013
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0013
5579 Carboxypeptidase B CPB1 0.0012
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0012
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0012
3384 Macrophage migration inhibitory factor MIF 0.0012
5287 Signaling protein Not Available 0.0011
5266 Activator of hgdC 0.0011
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0011
3199 Phosphopantetheine adenylyltransferase coaD 0.0011
3543 Phosphopantetheine adenylyltransferase coaD 0.0011
3567 Phosphopantetheine adenylyltransferase coaD 0.0011
5289 Phosphopantetheine adenylyltransferase coaD 0.0011
5293 Shikimate kinase 2 aroL 0.0011
5288 Shikimate kinase aroK 0.0011
5276 Chromosomal replication initiator protein dnaA dnaA 0.0011
5304 UPF0166 protein TM_0021 TM_0021 0.0011
5292 Putative partitioning protein TT_C1605 0.0011
2874 Nitrogenase iron protein 1 nifH1 0.0011
4346 Polynucleotide kinase pseT 0.0011
5277 Preprotein translocase subunit secA secA 0.0011
5283 D-alanine--D-alanine ligase B ddlB 0.0011
5281 Plasmid segregation protein parM parM 0.0011
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0011
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0011
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0011
5299 D-alanine--D-alanine ligase ddl 0.0011
6598 D-alanine--D-alanine ligase ddl 0.0011
5284 Large T antigen Not Available 0.0011
5285 Kinesin heavy chain KIF5B 0.0011
5259 Transcriptional regulator ntrC1 0.0011
6699 Transcriptional regulator Cgl2612 0.0011
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0011
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0011
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0011
5291 Glycogen synthase 1 glgA1 0.0011
5264 DNA replication protein REP 0.0011
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0011
5315 Chaperone protein htpG htpG 0.0011
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0011
5308 Preprotein translocase secA 1 subunit secA1 0.0011
128 Adenine phosphoribosyltransferase APRT 0.0011
3426 Glutamine synthetase glnA 0.001
3987 Glutamine synthetase GLUL 0.001
3470 Hypothetical protein MG245 homolog MPN_348 0.001
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.001
2270 Dephospho-CoA kinase coaE 0.001
5646 Galactokinase GALK1 0.001
4774 NTPase P4 Not Available 0.001
4106 Guanylate kinase GUK1 0.001
4516 Guanylate kinase gmk 0.001
2284 Adenylate kinase adk 0.001
2296 Adenylate kinase adk 0.001
2311 Adenylate kinase adk 0.001
2312 Adenylate kinase Not Available 0.001
3390 Aminoglycoside 3'-phosphotransferase aphA 0.001
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.001
5302 TrwB trwB 0.001
4837 Cag-alfa cag-alfa 0.001
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.001
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.001
5189 Trimethylamine dehydrogenase tmd 0.001
5265 FtsH ftsH 0.001
4839 DNA polymerase III subunit tau dnaX 0.001
6277 Heat shock cognate 71 kDa protein HSPA8 0.001
4838 PMS1 protein homolog 2 PMS2 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
822 Aldose reductase AKR1B1 0.0009
2683 Mono-ADP-ribosyltransferase C3 C3 0.0009
2922 Glycerol kinase glpK 0.0009
5271 Focal adhesion kinase 1 PTK2 0.0009
5312 Kinesin-like protein KIF1A KIF1A 0.0009
357 Carbonic anhydrase 2 CA2 0.0009
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
2892 Acetylglutamate kinase argB 0.0008
3550 Acetylglutamate kinase argB 0.0008
2371 Pantothenate kinase coaA 0.0008
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0008
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0008
3669 Ribokinase rbsK 0.0008
2615 Chemotaxis protein cheA cheA 0.0008
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0008
1881 Hexokinase-1 HK1 0.0008
2282 Protein recA recA 0.0008
2315 Protein recA recA 0.0008
2332 Protein recA recA 0.0008
5263 Protein recA recA 0.0008
408 Riboflavin kinase RFK 0.0008
2727 S-adenosylmethionine synthetase metK 0.0008
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0008
5300 Antigen peptide transporter 1 TAP1 0.0008
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0008
2334 Dethiobiotin synthetase bioD 0.0008
6555 Dethiobiotin synthetase bioD 0.0008
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0008
788 Creatine kinase M-type CKM 0.0008
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0007
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0007
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0007
6395 Myosin-14 MYH14 0.0007
702 UMP-CMP kinase CMPK1 0.0007
2091 Endoplasmin HSP90B1 0.0007
2251 Thymidylate kinase tmk 0.0007
2254 Thymidylate kinase DTYMK 0.0007
3522 Thymidylate kinase tmk 0.0007
48 Pyridoxal kinase PDXK 0.0007
1422 Serine/threonine-protein kinase 6 AURKA 0.0007
3379 Kinesin-like protein KIF11 KIF11 0.0007
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0007
3822 Actin, alpha skeletal muscle ACTA1 0.0006
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0006
509 Thymidine kinase TK 0.0006
570 Thymidine kinase TK 0.0006
2559 Thymidine kinase TK 0.0006
3430 Thymidine kinase tdk 0.0006
3518 Thymidine kinase TK 0.0006
5301 Thymidine kinase tdk 0.0006
5771 Thymidine kinase ORF36 0.0006
7009 Thymidine kinase ORF36 0.0006
504 Mast/stem cell growth factor receptor KIT 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
4773 Deoxycytidine kinase DCK 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
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