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Pyruvate kinase isozymes M1/M2


Partner ID 98
Name Pyruvate kinase isozymes M1/M2
Synonyms 309
Gene name PKM2
General function Carbohydrate transport and metabolism
Specific function Not Available
Gene sequence + ...

ATGTCGAAGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCACGCAGCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGATTCACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACGTTGAAGGAGATGATTAAGTCTGGAATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACTCATGAGTACCATGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCTGACCCCATCCTCTACCGGCCCGTTGCTGTGGCTCTAGACACTAAAGGACCTGAGATCCGAACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTCAAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTGTGGCTGGACTACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTTATTTCTCTCCAGGTGAAGCAGAAAGGTGCCGACTTCCTGGTGACGGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAGAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTTGATATGGTGTTTGCGTCATTCATCCGCAAGGCATCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAGAAGGGAAAGAACATCAAGATTATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTTGATGAAATCCTGGAGGCCAGTGATGGGATCATGGTGGCTCGTGGTGATCTAGGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGAACCTGATTGCCCGTGAGGCAGAGGCTGCCATCTACCACTTGCAATTATTTGAGGAACTCCGCCGCCTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCCTTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGA
Protein sequence + ...

SKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
GO Classification
function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
pyruvate kinase activity
process
alcohol metabolism
monosaccharide metabolism
hexose metabolism
glucose metabolism
glucose catabolism
physiological process
glycolysis
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00119 Pyruvic acid
DB01733 L-Phospholactate
DB02726 2-Phosphoglycolic Acid
DB07628 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
DB07692 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
DB07697 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine

Associated as Prediction

Id Name
DB00114 Pyridoxal Phosphate
DB00117 L-Histidine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00121 Biotin
DB00123 L-Lysine
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00157 NADH
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00172 L-Proline
DB00174 L-Asparagine
DB00175 Pravastatin
DB00279 Liothyronine
DB00313 Valproic Acid
DB00345 Aminohippurate
DB00415 Ampicillin
DB00451 Levothyroxine
DB00529 Foscarnet
DB00563 Methotrexate
DB00627 Niacin
DB00695 Furosemide
DB00731 Nateglinide
DB00770 Alprostadil
DB00780 Phenelzine
DB00917 Dinoprostone
DB00936 Salicyclic acid
DB01032 Probenecid
DB01080 Vigabatrin
DB01088 Iloprost
DB01160 Dinoprost Tromethamine
DB01174 Phenobarbital
DB01235 Levodopa
DB01440 Gamma Hydroxybutyric Acid
DB01583 Liotrix
DB01695 N-Hydroxy-4-Phosphono-Butanamide
DB01699 (4e)-4-Aminohex-4-Enoic Acid
DB01709 2-Phosphoglyceric Acid
DB01733 L-Phospholactate
DB01746 D-Leucine
DB01762 Acetoacetic Acid
DB01779 Glycerol-2-Phosphate
DB01786 D-Alanine
DB01819 Phosphoenolpyruvate
DB01942 Formic Acid
DB02263 Glyceraldehyde-3-Phosphate
DB02515 3-Phosphoglycerol
DB02556 D-Phenylalanine
DB02726 2-Phosphoglycolic Acid
DB02951 3-Hydroxypyruvic Acid
DB02952 Alpha-Aminoisobutyric Acid
DB03026 Phosphoglycolohydroxamic Acid
DB03066 D-Lactic Acid
DB03107 Beta-Alanine
DB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid
DB03135 [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
DB03166 Acetic acid
DB03225 D-Tryptophan
DB03314 Fluorotryptophane
DB03379 2-Carboxyethylphosphonic Acid
DB03581 Glucose-6-Phosphate
DB03793 Benzoic Acid
DB03839 D-Tyrosine
DB03884 3-Phenylpyruvic Acid
DB03900 2-Methyl-2-Propanol
DB03929 D-Serine
DB03940 Oxamic Acid
DB04074 Alpha-ketoisovalerate
DB04216 Quercetin
DB04235 4-Amino Hexanoic Acid
DB04277 Fructose -6-Phosphate
DB04319 6-Deoxyglucose
DB04326 1,3-Dihydroxyacetonephosphate
DB04343 Glyoxalate, Glyoxylate
DB04348 Taurocholic Acid
DB04398 Lactic Acid
DB04447 1,4-Dithiothreitol
DB04493 Fructose-6-Phosphate
DB04510 3-Phosphoglyceric Acid
DB04551 Fructose-1,6-Diphosphate
DB04552 Niflumic Acid
DB04557 Arachidonic Acid
DB06262 Droxidopa
DB07387 3-(BUTYLSULPHONYL)-PROPANOIC ACID
DB07497 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL
DB07628 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
DB07692 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
DB07697 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
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