DT-Web

DB00121 - Biotin


Identification
Name Biotin
Accession Number DB00121 (NUTR00019)
Type small molecule
Description A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 244.311
Groups approved
Monoisotopic Weight 244.088163078
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism of action Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
Absorption Systemic - approximately 50%
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Prolonged skin contact may cause irritation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Propionyl-CoA carboxylase beta chain, mitochondrial
Name Propionyl-CoA carboxylase beta chain, mitochondrial
Gene Name PCCB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Vlasova TI, Stratton SL, Wells AM, Mock NI, Mock DM: Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood. J Nutr. 2005 Jan;135(1):42-7. - Pubmed
  • Cherbonnel-Lasserre CL, Linares-Cruz G, Rigaut JP, Sabatier L, Dutrillaux B: Strong decrease in biotin content may correlate with metabolic alterations in colorectal adenocarcinoma. Int J Cancer. 1997 Sep 4;72(5):768-75. - Pubmed
  • Ishii M, Chuakrut S, Arai H, Igarashi Y: Occurrence, biochemistry and possible biotechnological application of the 3-hydroxypropionate cycle. Appl Microbiol Biotechnol. 2004 Jun;64(5):605-10. Epub 2004 Feb 28. - Pubmed
DTHybrid score 1.0616
Biotin--protein ligase
Name Biotin--protein ligase
Gene Name HLCS
Pharmacological action unknown
Actions Not Available
References
  • Velazquez-Arellano A: From an inborn error patient to a search for regulatory meaning: a biotin conducted voyage. Mol Genet Metab. 2006 Mar;87(3):194-7. Epub 2005 Dec 15. - Pubmed
  • Hassan YI, Zempleni J: Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006 Jul;136(7):1763-5. - Pubmed
  • Camporeale G, Giordano E, Rendina R, Zempleni J, Eissenberg JC: Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. J Nutr. 2006 Nov;136(11):2735-42. - Pubmed
DTHybrid score 1.1279
Sodium-dependent multivitamin transporter
Name Sodium-dependent multivitamin transporter
Gene Name SLC5A6
Pharmacological action unknown
Actions Not Available
References
  • Luo S, Kansara VS, Zhu X, Mandava NK, Pal D, Mitra AK: Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm. 2006 May-Jun;3(3):329-39. - Pubmed
  • Janoria KG, Hariharan S, Paturi D, Pal D, Mitra AK: Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT). Curr Eye Res. 2006 Oct;31(10):797-809. - Pubmed
  • Reidling JC, Said HM: Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1305-12. Epub 2006 Nov 29. - Pubmed
  • Camporeale G, Zempleni J, Eissenberg JC: Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. J Nutr. 2007 Apr;137(4):885-9. - Pubmed
DTHybrid score 1.6543
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Name Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Gene Name MCCC2
Pharmacological action unknown
Actions Not Available
References
  • Santoro N, Brtva T, Roest SV, Siegel K, Waldrop GL: A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase. Anal Biochem. 2006 Jul 1;354(1):70-7. Epub 2006 May 3. - Pubmed
  • de Queiroz MS, Waldrop GL: Modeling and numerical simulation of biotin carboxylase kinetics: implications for half-sites reactivity. J Theor Biol. 2007 May 7;246(1):167-75. Epub 2006 Dec 28. - Pubmed
  • Ludke A, Kramer R, Burkovski A, Schluesener D, Poetsch A: A proteomic study of Corynebacterium glutamicum AAA+ protease FtsH. BMC Microbiol. 2007 Jan 25;7:6. - Pubmed
  • Jitrapakdee S, Surinya KH, Adina-Zada A, Polyak SW, Stojkoski C, Smyth R, Booker GW, Cleland WW, Attwood PV, Wallace JC: Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers. Int J Biochem Cell Biol. 2007;39(11):2120-34. Epub 2007 Jun 27. - Pubmed
DTHybrid score 1.1281
Acetyl-CoA carboxylase 2
Name Acetyl-CoA carboxylase 2
Gene Name ACACB
Pharmacological action unknown
Actions Not Available
References
  • Liu Y, Zalameda L, Kim KW, Wang M, McCarter JD: Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening. Assay Drug Dev Technol. 2007 Apr;5(2):225-35. - Pubmed
DTHybrid score 1.6025
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Name Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene Name MCCC1
Pharmacological action unknown
Actions Not Available
References
  • Friebel D, von der Hagen M, Baumgartner ER, Fowler B, Hahn G, Feyh P, Heubner G, Baumgartner MR, Hoffmann GF: The first case of 3-methylcrotonyl-CoA carboxylase (MCC) deficiency responsive to biotin. Neuropediatrics. 2006 Apr;37(2):72-8. - Pubmed
DTHybrid score 1.1291
Pyruvate carboxylase, mitochondrial
Name Pyruvate carboxylase, mitochondrial
Gene Name PC
Pharmacological action unknown
Actions Not Available
References
  • Liu L, Li Y, Zhu Y, Du G, Chen J: Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metab Eng. 2007 Jan;9(1):21-9. Epub 2006 Aug 12. - Pubmed
  • Ferreira G, Weiss WP: Effect of biotin on activity and gene expression of biotin-dependent carboxylases in the liver of dairy cows. J Dairy Sci. 2007 Mar;90(3):1460-6. - Pubmed
  • Jitrapakdee S, Surinya KH, Adina-Zada A, Polyak SW, Stojkoski C, Smyth R, Booker GW, Cleland WW, Attwood PV, Wallace JC: Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers. Int J Biochem Cell Biol. 2007;39(11):2120-34. Epub 2007 Jun 27. - Pubmed
  • Jitrapakdee S, Adina-Zada A, Besant PG, Surinya KH, Cleland WW, Wallace JC, Attwood PV: Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA. Int J Biochem Cell Biol. 2007;39(6):1211-23. Epub 2007 Mar 30. - Pubmed
  • Ozimek PZ, Klompmaker SH, Visser N, Veenhuis M, van der Klei IJ: The transcarboxylase domain of pyruvate carboxylase is essential for assembly of the peroxisomal flavoenzyme alcohol oxidase. FEMS Yeast Res. 2007 Oct;7(7):1082-92. Epub 2007 Feb 20. - Pubmed
DTHybrid score 0.9894
Propionyl-CoA carboxylase alpha chain, mitochondrial
Name Propionyl-CoA carboxylase alpha chain, mitochondrial
Gene Name PCCA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Clavero S, Martinez MA, Perez B, Perez-Cerda C, Ugarte M, Desviat LR: Functional characterization of PCCA mutations causing propionic acidemia. Biochim Biophys Acta. 2002 Nov 20;1588(2):119-25. - Pubmed
  • Cherbonnel-Lasserre CL, Linares-Cruz G, Rigaut JP, Sabatier L, Dutrillaux B: Strong decrease in biotin content may correlate with metabolic alterations in colorectal adenocarcinoma. Int J Cancer. 1997 Sep 4;72(5):768-75. - Pubmed
  • Vlasova TI, Stratton SL, Wells AM, Mock NI, Mock DM: Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood. J Nutr. 2005 Jan;135(1):42-7. - Pubmed
DTHybrid score 1.129
Acetyl-CoA carboxylase 1
Name Acetyl-CoA carboxylase 1
Gene Name ACACA
Pharmacological action unknown
Actions Not Available
References
  • Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL: The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Biochemistry. 2006 Feb 14;45(6):1712-22. - Pubmed
  • Brownsey RW, Boone AN, Elliott JE, Kulpa JE, Lee WM: Regulation of acetyl-CoA carboxylase. Biochem Soc Trans. 2006 Apr;34(Pt 2):223-7. - Pubmed
  • Aoki H, Kimura K, Igarashi K, Takenaka A: Soy protein suppresses gene expression of acetyl-coA carboxylase alpha from promoter PI in rat liver. Biosci Biotechnol Biochem. 2006 Apr;70(4):843-9. - Pubmed
  • Santoro N, Brtva T, Roest SV, Siegel K, Waldrop GL: A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase. Anal Biochem. 2006 Jul 1;354(1):70-7. Epub 2006 May 3. - Pubmed
  • Leonard E, Lim KH, Saw PN, Koffas MA: Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl Environ Microbiol. 2007 Jun;73(12):3877-86. Epub 2007 Apr 27. - Pubmed
DTHybrid score 1.1311

Enzymes


Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4809

Predictions


Id Partner name Gene Name Score
246 Valyl-tRNA synthetase VARS 0.2063
6468 Pyruvate carboxylase pycA 0.1954
6467 Acyl-CoA carboxylase yngHB 0.1952
45 Lipoyltransferase 1, mitochondrial LIPT1 0.1647
4079 Lipoic acid synthetase, mitochondrial LIAS 0.1647
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.1215
6151 Monocarboxylate transporter 10 SLC16A10 0.1023
4120 NADPH--cytochrome P450 reductase POR 0.0871
6024 Cytochrome P450 1A1 CYP1A1 0.0473
4512 Cytochrome P450 3A4 CYP3A4 0.0332
397 Monocarboxylate transporter 3 SLC16A8 0.0327
195 Monocarboxylate transporter 7 SLC16A6 0.0327
218 Monocarboxylate transporter 5 SLC16A4 0.0327
429 Monocarboxylate transporter 6 SLC16A5 0.0327
4200 Cytochrome P450 1A2 CYP1A2 0.0311
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0268
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0268
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0268
52 Pyruvate kinase isozymes R/L PKLR 0.0266
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0263
1588 Multidrug resistance protein 1 ABCB1 0.0263
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0259
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0259
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0254
4692 A/G-specific adenine glycosylase mutY 0.0248
4606 Purine trans deoxyribosylase ptd 0.0246
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.0237
3679 MTA/SAH nucleosidase mtnN 0.0236
4924 Cytochrome P450 2C8 CYP2C8 0.0231
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0229
3947 Xanthine dehydrogenase/oxidase XDH 0.0228
4757 Cytochrome P450 2C9 CYP2C9 0.0223
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0221
4118 Cytochrome P450 3A5 CYP3A5 0.0215
4119 Cytochrome P450 2D6 CYP2D6 0.0213
500 Monocarboxylate transporter 4 SLC16A3 0.0211
128 Adenine phosphoribosyltransferase APRT 0.0209
489 Monocarboxylate transporter 2 SLC16A7 0.0207
199 Monocarboxylate transporter 8 SLC16A2 0.0198
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0197
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0195
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0184
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0176
6016 Cytochrome P450 2C19 CYP2C19 0.0168
738 Monocarboxylate transporter 1 SLC16A1 0.0165
6013 Cytochrome P450 2E1 CYP2E1 0.0155
862 Multidrug resistance-associated protein 1 ABCC1 0.0137
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0137
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0134
6107 Cytochrome P450 3A7 CYP3A7 0.0125
776 Bile salt export pump ABCB11 0.0123
4228 Keratin, type II cytoskeletal 7 KRT7 0.0104
6148 Multidrug resistance-associated protein 7 ABCC10 0.01
468 Cytochrome P450 4A11 CYP4A11 0.0095
6030 Cytochrome P450 2B6 CYP2B6 0.0095
817 DNA topoisomerase 2-alpha TOP2A 0.0092
5718 Cytochrome P450 2A6 CYP2A6 0.0085
6106 Cytochrome P450 2C18 CYP2C18 0.0085
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0082
4203 Histamine N-methyltransferase HNMT 0.008
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0078
3811 Cytochrome P450 19A1 CYP19A1 0.0077
136 Estrogen receptor ESR1 0.0076
5923 Microtubule-associated protein tau MAPT 0.007
5924 Microtubule-associated protein 4 MAP4 0.007
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0069
587 Serum albumin ALB 0.0068
6220 Aryl hydrocarbon receptor AHR 0.0068
1852 Microtubule-associated protein 2 MAP2 0.0065
6147 Solute carrier family 22 member 3 SLC22A3 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0062
6144 Solute carrier family 22 member 2 SLC22A2 0.0061
16 Adenosine A1 receptor ADORA1 0.0057
1178 Adenosine A2a receptor ADORA2A 0.0056
1569 G1/S-specific cyclin-D1 CCND1 0.0056
146 Androgen receptor AR 0.0056
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0056
29 Tubulin beta-1 chain TUBB1 0.0054
6143 Solute carrier family 22 member 7 SLC22A7 0.0053
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0053
6145 Solute carrier family 22 member 1 SLC22A1 0.0052
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0052
1629 Transcription factor AP-1 JUN 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
1714 Mitogen-activated protein kinase 3 MAPK3 0.0045
3830 Calreticulin CALR 0.0044
1757 Myeloperoxidase MPO 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
2236 Casein kinase II subunit alpha CSNK2A1 0.0043
6137 Multidrug resistance-associated protein 6 ABCC6 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0042
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
6036 Eosinophil peroxidase EPX 0.0041
380 Cytochrome P450 17A1 CYP17A1 0.004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0039
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0039
6142 Solute carrier family 22 member 8 SLC22A8 0.0038
373 Transthyretin TTR 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
814 Ryanodine receptor 1 RYR1 0.0038
844 Epidermal growth factor receptor EGFR 0.0036
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
1176 Mitogen-activated protein kinase 1 MAPK1 0.0035
290 Prostaglandin G/H synthase 2 PTGS2 0.0035
6141 Sodium/bile acid cotransporter SLC10A1 0.0034
6031 Cytochrome P450 3A43 CYP3A43 0.0034
268 Adenosine A2b receptor ADORA2B 0.0034
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0034
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0034
362 Melatonin receptor type 1B MTNR1B 0.0033
571 Melatonin receptor type 1A MTNR1A 0.0033
20 Prostaglandin G/H synthase 1 PTGS1 0.0032
936 Ephrin type-A receptor 2 EPHA2 0.0032
484 Tyrosine-protein kinase ABL2 ABL2 0.0031
756 Sex hormone-binding globulin SHBG 0.0031
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.003
6163 Copper-transporting ATPase 2 ATP7B 0.003
6165 Copper-transporting ATPase 1 ATP7A 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.003
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
228 Beta platelet-derived growth factor receptor PDGFRB 0.0029
6146 High affinity copper uptake protein 1 SLC31A1 0.0029
4122 Histone deacetylase 2 HDAC2 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0028
908 Glutathione S-transferase theta-1 GSTT1 0.0027
869 Estrogen receptor beta ESR2 0.0027
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
504 Mast/stem cell growth factor receptor KIT 0.0026
7 Nitric oxide synthase, inducible NOS2 0.0026
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
1010 Cytochrome P450 51A1 CYP51A1 0.0026
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0025
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
896 Glutathione S-transferase Mu 1 GSTM1 0.0024
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0024
3937 Fatty-acid amide hydrolase FAAH 0.0024
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
84 Nuclear receptor 0B1 NR0B1 0.0023
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0023
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0023
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0023
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0023
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0023
6168 Solute carrier family 22 member 16 SLC22A16 0.0023
469 Annexin A1 ANXA1 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0022
260 Cytochrome P450 51 ERG11 0.0022
761 Cytochrome P450 51 ERG11 0.0022
3163 Cytochrome P450 51 cyp51 0.0022
3957 Adenosine deaminase ADA 0.0022
465 Calmodulin CALM1 0.0021
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0021
904 Glutathione S-transferase P GSTP1 0.0021
6014 Cytochrome P450 2A13 CYP2A13 0.0021
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0021
737 Mineralocorticoid receptor NR3C2 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0019
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0018
614 Progesterone receptor PGR 0.0018
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0018
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0018
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0016
164 Histamine H4 receptor HRH4 0.0016
4604 Liver carboxylesterase 1 CES1 0.0015
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0015
76 Nitric-oxide synthase, brain NOS1 0.0014
833 Organic cation/carnitine transporter 1 SLC22A4 0.0014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
3941 Amine oxidase [flavin-containing] A MAOA 0.0014
871 Glucocorticoid receptor NR3C1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0013
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0013
1256 5-hydroxytryptamine 6 receptor HTR6 0.0012
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0012
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0012
1024 Solute carrier family 22 member 11 SLC22A11 0.0012
921 Glutamate receptor 2 GRIA2 0.0011
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0011
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0011
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0011
716 5-hydroxytryptamine 7 receptor HTR7 0.0011
341 5-hydroxytryptamine 3 receptor HTR3A 0.001
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.001
432 D(4) dopamine receptor DRD4 0.001
725 5-hydroxytryptamine 1D receptor HTR1D 0.001
885 5-hydroxytryptamine 1B receptor HTR1B 0.0009
638 D(3) dopamine receptor DRD3 0.0009
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0009
378 Alpha-2C adrenergic receptor ADRA2C 0.0009
629 Alpha-2B adrenergic receptor ADRA2B 0.0009
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0009
590 5-hydroxytryptamine 2C receptor HTR2C 0.0009
632 Alpha-1B adrenergic receptor ADRA1B 0.0009
320 5-hydroxytryptamine 1A receptor HTR1A 0.0009
23 D(1A) dopamine receptor DRD1 0.0008
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0008
318 Alpha-2A adrenergic receptor ADRA2A 0.0008
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0008
502 5-hydroxytryptamine 2A receptor HTR2A 0.0008
831 D(2) dopamine receptor DRD2 0.0008
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0008
556 Alpha-1A adrenergic receptor ADRA1A 0.0008
492 Histamine H1 receptor HRH1 0.0008
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