DT-Web

DB00415 - Ampicillin


Identification
Name Ampicillin
Accession Number DB00415 (APRD00320)
Type small molecule
Description Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 349.405
Groups approved
Monoisotopic Weight 349.109626801
Pharmacology
Indication For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Mechanism of action By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Ampicillin is excreted largely unchanged in the urine.
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Atenolol Ampicillin decreases bioavailability of atenolol
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline Possible antagonism of action
Methotrexate The penicillin increases the effect and toxicity of methotrexate
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions
  • Take on an empty stomach.

Targets


Penicillin-binding protein 2a
Name Penicillin-binding protein 2a
Gene Name pbp2a
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score Not Available
Penicillin-binding protein 1b
Name Penicillin-binding protein 1b
Gene Name pbp1b
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
DTHybrid score 0.0713
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
  • Li YH, Tanno M, Itoh T, Yamada H: Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. Int J Pharm. 1999 Nov 30;191(2):151-9. - Pubmed
DTHybrid score 0.037
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0857
Penicillin-binding protein 2B
Name Penicillin-binding protein 2B
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score 0.0147

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.3876
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Covitz KM, Amidon GL, Sadee W: Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res. 1996 Nov;13(11):1631-4. - Pubmed
  • Guo A, Hu P, Balimane PV, Leibach FH, Sinko PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther. 1999 Apr;289(1):448-54. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM: Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20. - Pubmed
DTHybrid score 0.7308
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.7299
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions Not Available
References
  • Li YH, Tanno M, Itoh T, Yamada H: Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. Int J Pharm. 1999 Nov 30;191(2):151-9. - Pubmed
DTHybrid score 0.2514

Carriers


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions
References Not Available
DTHybrid score 0.3876
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions
References Not Available
DTHybrid score 0.7308
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions
References Not Available
DTHybrid score 0.7299
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions
References Not Available
DTHybrid score 0.2514

Predictions


Id Partner name Gene Name Score
1729 Solute carrier family 22 member 6 SLC22A6 0.2583
633 Penicillin-binding proteins 1A/1B pbpA 0.2134
244 Angiotensin-converting enzyme ACE 0.1763
6142 Solute carrier family 22 member 8 SLC22A8 0.1506
4512 Cytochrome P450 3A4 CYP3A4 0.1181
489 Monocarboxylate transporter 2 SLC16A7 0.1134
1024 Solute carrier family 22 member 11 SLC22A11 0.093
1 Peptidoglycan synthetase ftsI ftsI 0.0901
4155 Peptidoglycan synthetase ftsI ftsI 0.0901
500 Monocarboxylate transporter 4 SLC16A3 0.0888
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0878
645 Penicillin-binding protein 1A mrcA 0.0857
5805 Penicillin-binding protein 1A ponA 0.0857
6185 Penicillin-binding protein 1A mrcA 0.0857
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0824
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0824
1588 Multidrug resistance protein 1 ABCB1 0.0805
543 Penicillin-binding protein 1B mrcB 0.0713
6186 Penicillin-binding protein 1B ponB 0.0713
6822 Penicillin-binding protein 1b pbp1b 0.0713
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0702
4119 Cytochrome P450 2D6 CYP2D6 0.0698
6143 Solute carrier family 22 member 7 SLC22A7 0.0693
4757 Cytochrome P450 2C9 CYP2C9 0.0592
4200 Cytochrome P450 1A2 CYP1A2 0.0575
833 Organic cation/carnitine transporter 1 SLC22A4 0.0514
6067 Penicillin binding protein 2a mecA 0.0491
6016 Cytochrome P450 2C19 CYP2C19 0.0477
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0459
6145 Solute carrier family 22 member 1 SLC22A1 0.0444
20 Prostaglandin G/H synthase 1 PTGS1 0.042
3760 Penicillin-binding protein 5 precursor dacA 0.0414
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0411
867 Penicillin-binding protein 3 pbpC 0.037
6119 Penicillin-binding protein 3 pbp3 0.037
7157 Penicillin-binding protein 3 LMHCC_2184 0.037
7162 Penicillin-binding protein 3 pbpB 0.037
7172 Penicillin-binding protein 3 pbp3 0.037
4924 Cytochrome P450 2C8 CYP2C8 0.0367
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.036
3195 Beta-lactamase Toho-1 bla 0.0357
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0357
1385 Angiotensin-converting enzyme 2 ACE2 0.035
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0344
115 Penicillin-binding protein 2 mrdA 0.0335
6069 Penicillin-binding protein 2 mrdA 0.0335
6118 Penicillin-binding protein 2 penA 0.0335
6187 Penicillin-binding protein 2 pbpA 0.0335
6686 Penicillin-binding protein 2 pbp2 0.0335
6939 Penicillin-binding protein 2 mrdA 0.0335
7163 Penicillin-binding protein 2 pbpA 0.0335
6144 Solute carrier family 22 member 2 SLC22A2 0.0325
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0308
1757 Myeloperoxidase MPO 0.0303
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0298
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0298
862 Multidrug resistance-associated protein 1 ABCC1 0.0297
819 Penicillin-binding protein 4 dacB 0.0294
4118 Cytochrome P450 3A5 CYP3A5 0.0277
290 Prostaglandin G/H synthase 2 PTGS2 0.0261
3923 Cholinesterase BCHE 0.0258
2929 (S)-2-haloacid dehalogenase dhlB 0.0248
2995 (S)-2-haloacid dehalogenase Not Available 0.0248
234 Plasminogen PLG 0.0246
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0236
338 DNA polymerase UL30 0.0236
379 DNA polymerase UL54 0.0236
697 DNA polymerase ORF28 0.0236
2482 DNA polymerase 43 0.0236
4104 DNA polymerase BALF5 0.0236
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0235
6147 Solute carrier family 22 member 3 SLC22A3 0.0234
2164 Multidrug resistance-associated protein 4 ABCC4 0.0233
4604 Liver carboxylesterase 1 CES1 0.0232
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
3426 Glutamine synthetase glnA 0.0213
3987 Glutamine synthetase GLUL 0.0213
891 Dihydropteroate synthase folP 0.0207
5359 Dihydropteroate synthase folP 0.0207
7175 Dihydropteroate synthase sulI 0.0207
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
3917 Methylenetetrahydrofolate reductase MTHFR 0.0196
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0192
6030 Cytochrome P450 2B6 CYP2B6 0.0192
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0177
2508 Cyclomaltodextrin glucanotransferase cgt 0.0177
2523 Cyclomaltodextrin glucanotransferase cgt 0.0177
3207 Cyclomaltodextrin glucanotransferase amyA 0.0177
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
6107 Cytochrome P450 3A7 CYP3A7 0.0165
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3179 2-isopropylmalate synthase leuA 0.0159
6106 Cytochrome P450 2C18 CYP2C18 0.0159
860 Nicotinamide N-methyltransferase NNMT 0.0157
928 Nicotinic acid receptor 2 GPR109B 0.0157
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0157
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0157
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0157
699 Nicotinic acid receptor 1 GPR109A 0.0157
6151 Monocarboxylate transporter 10 SLC16A10 0.0152
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
159 Penicillin-binding protein 2B penA 0.0147
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0146
4252 Penicillin-binding protein 5 dacA 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
5650 NimA-related protein DR_0842 0.0142
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0139
318 Alpha-2A adrenergic receptor ADRA2A 0.0139
4132 Chloride channel protein ClC-Ka CLCNKA 0.0139
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0137
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0133
817 DNA topoisomerase 2-alpha TOP2A 0.0131
3334 Deacetoxycephalosporin C synthetase cefE 0.0127
632 Alpha-1B adrenergic receptor ADRA1B 0.0125
5718 Cytochrome P450 2A6 CYP2A6 0.0125
556 Alpha-1A adrenergic receptor ADRA1A 0.0124
6024 Cytochrome P450 1A1 CYP1A1 0.0118
6149 Solute carrier family 22 member 10 SLC22A10 0.0118
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0116
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0115
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0112
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0111
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0109
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0108
6013 Cytochrome P450 2E1 CYP2E1 0.0107
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0107
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0107
3810 Catechol O-methyltransferase COMT 0.0106
776 Bile salt export pump ABCB11 0.0103
492 Histamine H1 receptor HRH1 0.0103
509 Thymidine kinase TK 0.0101
570 Thymidine kinase TK 0.0101
2559 Thymidine kinase TK 0.0101
3430 Thymidine kinase tdk 0.0101
3518 Thymidine kinase TK 0.0101
5301 Thymidine kinase tdk 0.0101
5771 Thymidine kinase ORF36 0.0101
7009 Thymidine kinase ORF36 0.0101
2211 Fatty acid-binding protein, heart FABP3 0.0098
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0098
6137 Multidrug resistance-associated protein 6 ABCC6 0.0096
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0096
566 Serotransferrin TF 0.0094
23 D(1A) dopamine receptor DRD1 0.0091
6141 Sodium/bile acid cotransporter SLC10A1 0.009
6010 Thiamine transporter 1 SLC19A2 0.0089
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0088
6500 Phospholipase A2 PLA2G1B 0.0085
831 D(2) dopamine receptor DRD2 0.0085
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0084
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0083
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0082
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
502 5-hydroxytryptamine 2A receptor HTR2A 0.0078
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0077
723 Cytosolic phospholipase A2 PLA2G4A 0.0076
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0076
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0074
629 Alpha-2B adrenergic receptor ADRA2B 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0071
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.007
707 72 kDa type IV collagenase MMP2 0.007
705 Glutamate receptor 1 GRIA1 0.007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
558 Solute carrier family 12 member 1 SLC12A1 0.0068
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0067
36 Insulin receptor INSR 0.0066
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0066
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0066
3014 Ribonuclease UK114 HRSP12 0.0064
5428 Replication protein repA 0.0064
3617 Non-heme chloroperoxidase cpo 0.0064
5426 Non-heme chloroperoxidase cpo 0.0064
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0064
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0064
3018 HTH-type transcriptional regulator malT malT 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
474 Acetylcholinesterase ACHE 0.0063
844 Epidermal growth factor receptor EGFR 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
380 Cytochrome P450 17A1 CYP17A1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
756 Sex hormone-binding globulin SHBG 0.006
6218 Pannexin-1 PANX1 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
397 Monocarboxylate transporter 3 SLC16A8 0.0059
195 Monocarboxylate transporter 7 SLC16A6 0.0058
199 Monocarboxylate transporter 8 SLC16A2 0.0058
218 Monocarboxylate transporter 5 SLC16A4 0.0058
429 Monocarboxylate transporter 6 SLC16A5 0.0058
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
6837 Serine/threonine-protein kinase 17B STK17B 0.0057
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0057
65 Matrix metalloproteinase-9 Not Available 0.0057
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0057
788 Creatine kinase M-type CKM 0.0057
2958 Probable tautomerase ydcE pptA 0.0055
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0055
2573 Cocaine esterase cocE 0.0055
7263 Cocaine esterase Not Available 0.0055
824 Sodium-dependent serotonin transporter SLC6A4 0.0055
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0054
3115 Ras-related protein Rab-9 RAB9A 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
320 5-hydroxytryptamine 1A receptor HTR1A 0.0054
1039 Histone deacetylase 9 HDAC9 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0052
52 Pyruvate kinase isozymes R/L PKLR 0.0052
5482 Sialidase-2 NEU2 0.0052
183 Vascular endothelial growth factor A VEGFA 0.0052
6148 Multidrug resistance-associated protein 7 ABCC10 0.0051
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.0049
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0049
771 Pyruvate carboxylase, mitochondrial PC 0.0049
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0048
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
6136 Multidrug resistance-associated protein 5 ABCC5 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0046
6599 HTH-type transcriptional regulator ttgR ttgR 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
789 Alpha-1D adrenergic receptor ADRA1D 0.0045
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0045
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0044
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
373 Transthyretin TTR 0.0044
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
33 Cystine/glutamate transporter SLC7A11 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0043
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0042
3941 Amine oxidase [flavin-containing] A MAOA 0.0042
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0042
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0042
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0042
2693 Heat-labile enterotoxin B chain eltB 0.0042
163 D(1B) dopamine receptor DRD5 0.0041
193 Beta-1 adrenergic receptor ADRB1 0.0041
6645 D-amino-acid oxidase DAO 0.0041
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
432 D(4) dopamine receptor DRD4 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
638 D(3) dopamine receptor DRD3 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
5818 Folate receptor alpha FOLR1 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
1517 Beta-3 adrenergic receptor ADRB3 0.0037
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0036
70 Type-1 angiotensin II receptor AGTR1 0.0036
5126 Arginase rocF 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0035
1341 Histamine H3 receptor HRH3 0.0034
124 Histamine H2 receptor HRH2 0.0034
3587 Gastrotropin FABP6 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0033
499 Arginine decarboxylase ADC 0.0033
293 Gamma-glutamyl hydrolase GGH 0.0032
164 Histamine H4 receptor HRH4 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
136 Estrogen receptor ESR1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
459 Retinoic acid receptor RXR-alpha RXRA 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.003
1650 Heme carrier protein 1 SLC46A1 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
24 Thymidylate synthase TMP1 0.0029
359 Thymidylate synthase TYMS 0.0029
2626 Thymidylate synthase thyA 0.0029
2729 Thymidylate synthase thyA 0.0029
5352 Thymidylate synthase THYA 0.0029
146 Androgen receptor AR 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
1898 Cytochrome P450 1B1 CYP1B1 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0025
976 Platelet glycoprotein IX GP9 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0025
847 Mu-type opioid receptor OPRM1 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
811 Translocator protein TSPO 0.0024
1867 Major prion protein PRNP 0.0024
6432 Transporter snf 0.0024
6231 Pepsin A PGA3 0.0024
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0023
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
6102 Arylamine N-acetyltransferase 2 NAT2 0.0023
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
6020 Aldehyde oxidase AOX1 0.0022
365 Dihydrofolate reductase DHFR 0.0022
2381 Dihydrofolate reductase DFR1 0.0022
2833 Dihydrofolate reductase Not Available 0.0022
2931 Dihydrofolate reductase folA 0.0022
3544 Dihydrofolate reductase folA 0.0022
3682 Dihydrofolate reductase folA 0.0022
6642 Dihydrofolate reductase folA 0.0022
6756 Dihydrofolate reductase dfrA 0.0022
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
1050 Bile salt sulfotransferase SULT2A1 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.002
7 Nitric oxide synthase, inducible NOS2 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
274 Muscarinic acetylcholine receptor M5 CHRM5 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1992 Vitamin D-binding protein GC 0.002
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
869 Estrogen receptor beta ESR2 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
6014 Cytochrome P450 2A13 CYP2A13 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
3811 Cytochrome P450 19A1 CYP19A1 0.0017
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
1714 Mitogen-activated protein kinase 3 MAPK3 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0017
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
2207 Rhodopsin RHO 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
172 Potassium channel subfamily K member 1 KCNK1 0.0015
614 Progesterone receptor PGR 0.0015
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
871 Glucocorticoid receptor NR3C1 0.0014
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0014
465 Calmodulin CALM1 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
467 Delta-type opioid receptor OPRD1 0.0013
1656 CYP2B protein CYP2B 0.0013
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0013
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0013
1912 Excitatory amino acid transporter 1 SLC1A3 0.0013
4019 Excitatory amino acid transporter 4 SLC1A6 0.0013
922 Glutamate receptor 4 GRIA4 0.0013
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0013
4026 Aspartyl aminopeptidase DNPEP 0.0013
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0013
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0013
4016 Excitatory amino acid transporter 5 SLC1A7 0.0013
1047 Excitatory amino acid transporter 2 SLC1A2 0.0013
927 Metabotropic glutamate receptor 8 GRM8 0.0013
664 Glutamate decarboxylase 2 GAD2 0.0013
3890 Glutamate decarboxylase 2 GAD2 0.0013
4020 Glutamyl aminopeptidase ENPEP 0.0013
4018 Glutamate receptor delta-2 subunit GRID2 0.0013
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0013
925 Metabotropic glutamate receptor 4 GRM4 0.0013
926 Metabotropic glutamate receptor 7 GRM7 0.0013
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0013
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0013
4027 Glutamate receptor delta-1 subunit GRID1 0.0013
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0013
4017 5-oxoprolinase OPLAH 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0013
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0013
6459 Glycodelin PAEP 0.0013
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
822 Aldose reductase AKR1B1 0.0012
625 Glutamate carboxypeptidase 2 FOLH1 0.0012
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0012
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0011
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0011
5 Glutaminase liver isoform, mitochondrial GLS2 0.0011
917 Glutaminase kidney isoform, mitochondrial GLS 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0011
5261 Phosphoribosylformylglycinamidine synthase purL 0.0011
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
916 Metabotropic glutamate receptor 1 GRM1 0.0011
665 Phosphoserine aminotransferase PSAT1 0.0011
4652 Phosphoserine aminotransferase serC 0.0011
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0011
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0011
420 Glutamate decarboxylase 1 GAD1 0.0011
3900 Glutamate decarboxylase 1 GAD1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0011
923 Glutamate receptor 3 GRIA3 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
1671 Excitatory amino acid transporter 3 SLC1A1 0.001
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.001
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.001
3877 Growth-inhibiting protein 18 GIG18 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
426 Aspartate aminotransferase, mitochondrial GOT2 0.001
914 Formimidoyltransferase-cyclodeaminase FTCD 0.001
763 Tyrosine aminotransferase TAT 0.001
5493 Tyrosine aminotransferase Not Available 0.001
2021 Thrombomodulin THBD 0.001
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.001
735 Alanine aminotransferase 1 GPT 0.001
3904 Alanine aminotransferase 2 GPT2 0.001
586 Aspartate aminotransferase, cytoplasmic GOT1 0.001
904 Glutathione S-transferase P GSTP1 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
436 5-hydroxytryptamine 2B receptor HTR2B 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0009
1864 RET proto-oncogene RET 0.0009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0009
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0009
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0009
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
468 Cytochrome P450 4A11 CYP4A11 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
3639 Thymidine phosphorylase deoA 0.0008
3936 Thymidine phosphorylase TYMP 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0008
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0008
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0007
1792 Tissue-type plasminogen activator PLAT 0.0007
228 Beta platelet-derived growth factor receptor PDGFRB 0.0007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
921 Glutamate receptor 2 GRIA2 0.0007
273 Apoptosis regulator Bcl-2 BCL2 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
504 Mast/stem cell growth factor receptor KIT 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
6031 Cytochrome P450 3A43 CYP3A43 0.0005
5961 Insulin INS 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
716 5-hydroxytryptamine 7 receptor HTR7 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
725 5-hydroxytryptamine 1D receptor HTR1D 0.0003
885 5-hydroxytryptamine 1B receptor HTR1B 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
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