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Cationic amino acid transporter 3


Partner ID 150
Name Cationic amino acid transporter 3
Synonyms 461
Gene name SLC7A3
General function Amino acid transport and metabolism
Specific function Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner
Gene sequence + ...

ATGCCGTGGCAAGCATTTCGCAGATTTGGTCAAAAGCTGGTACGCAGACGTACACTGGAGTCAGGCATGGCTGAGACTCGCCTTGCCAGATGCCTAAGCACCCTGGATTTAGTGGCCCTGGGTGTGGGCAGCACATTGGGTGCAGGCGTGTATGTCCTAGCTGGCGAGGTGGCCAAAGATAAAGCAGGGCCATCCATTGTGATCTGCTTTTTGGTGGCTGCCCTGTCTTCTGTGTTGGCTGGGCTGTGCTATGCGGAGTTTGGTGCCCGGGTTCCCCGTTCTGGTTCGGCATATCTCTACAGCTATGTCACTGTGGGTGAACTCTGGGCCTTCACCACTGGCTGGAACCTCATCCTCTCCTATGTCATTGGTACAGCCAGTGTGGCCCGGGCCTGGAGCTCTGCTTTTGACAACCTGATTGGGAACCACATCTCTAAGACTCTGCAGGGGTCCATTGCACTGCACGTGCCCCATGTCCTTGCAGAATATCCAGATTTCTTTGCTTTGGGCCTCGTGTTGCTGCTCACTGGATTGTTGGCTCTCGGGGCTAGTGAGTCGGCCCTGGTTACCAAAGTGTTCACAGGCGTGAACCTTTTGGTTCTTGGGTTCGTCATGATCTCTGGCTTCGTTAAGGGGGACGTGCACAACTGGAAGCTCACAGAAGAGGACTACGAATTGGCCATGGCTGAACTCAATGACACCTATAGCTTGGGTCCTCTGGGCTCTGGAGGATTTGTGCCTTTCGGCTTCGAGGGAATTCTCCGTGGAGCAGCGACCTGTTTCTATGCATTTGTTGGTTTCGACTGTATTGCTACCACTGGAGAAGAAGCCCAGAATCCCCAGCGTTCCATCCCGATGGGCATTGTGATCTCACTGTCTGTCTGCTTTTTGGCGTATTTTGCTGTCTCTTCTGCACTCACCCTGATGATGCCTTACTACCAGCTTCAGCCTGAGAGCCCTTTGCCTGAGGCATTTCTCTACATTGGATGGGCTCCTGCCCGCTATGTTGTGGCTGTTGGCTCCCTCTGTGCTCTTTCTACCAGCCTCCTGGGCTCCATGTTCCCCATGCCTCGGGTGATCTACGCGATGGCAGAGGATGGCCTCCTGTTCCGTGTACTTGCTCGGATCCACACCGGCACACGCACCCCAATCATAGCCACCGTGGTCTCTGGCATTATTGCAGCATTCATGGCATTCCTCTTCAAACTCACTGATCTTGTGGACCTCATGTCAATTGGGACCCTGCTTGCTTACTCCCTGGTGTCGATTTGTGTTCTCATCCTCAGGTATCAACCTGATCAGGAGACAAAGACTGGGGAAGAAGTGGAGTTGCAGGAGGAGGCAATAACTACTGAATCAGAGAAGTTGACCCTATGGGGACTATTTTTCCCACTCAACTCCATCCCCACTCCACTCTCTGGCCAAATTGTCTATGTTTGTTCCTCATTGCTTGCTGTCCTGCTGACTGCTCTTTGCCTGGTGCTGGCCCAGTGGTCAGTTCCATTGCTTTCTGGAGACCTGCTGTGGACTGCAGTGGTTGTGCTGCTCCTGCTGCTCATTATTGGGATCATTGTGGTCATCTGGAGACAGCCACAGAGTTCCACTCCCCTTCACTTTAAGGTGCCTGCTTTGCCTCTCCTCCCACTAATGAGCATCTTTGTGAATATTTACCTTATGATGCAGATGACAGCTGGTACCTGGGCCCGATTTGGGGTCTGGATGCTGATTGGCTTTGCTATCTACTTCGGCTATGGGATCCAGCACAGCCTGGAAGAGATTAAGAGTAACCAACCCTCACGCAAGTCTAGAGCCAAAACTGTAGACCTTGATCCCGGCACTCTCTATGTCCACTCAGTTTGA
Protein sequence + ...

MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTLYVHSV
GO Classification
component
cell
intrinsic to membrane
integral to membrane
membrane
function
amino acid permease activity
amine transporter activity
amino acid transporter activity
amino acid-polyamine transporter activity
transporter activity
process
amine transport
physiological process
amino acid transport
cellular physiological process
transport
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00123 L-Lysine
DB00125 L-Arginine
DB00129 L-Ornithine

Associated as Prediction

Id Name
DB00114 Pyridoxal Phosphate
DB00117 L-Histidine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00122 Choline
DB00123 L-Lysine
DB00125 L-Arginine
DB00127 Spermine
DB00128 L-Aspartic Acid
DB00129 L-Ornithine
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00148 Creatine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00152 Thiamine
DB00155 L-Citrulline
DB00156 L-Threonine
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00182 Amphetamine
DB00184 Nicotine
DB00279 Liothyronine
DB00281 Lidocaine
DB00313 Valproic Acid
DB00332 Ipratropium bromide
DB00345 Aminohippurate
DB00360 Tetrahydrobiopterin
DB00365 Grepafloxacin
DB00368 Norepinephrine
DB00415 Ampicillin
DB00438 Ceftazidime
DB00456 Cefalotin
DB00458 Imipramine
DB00468 Quinine
DB00501 Cimetidine
DB00535 Cefdinir
DB00536 Guanidine
DB00567 Cephalexin
DB00575 Clonidine
DB00583 L-Carnitine
DB00594 Amiloride
DB00624 Testosterone
DB00627 Niacin
DB00661 Verapamil
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00671 Cefixime
DB00689 Cephaloglycin
DB00695 Furosemide
DB00908 Quinidine
DB00970 Dactinomycin
DB00978 Lomefloxacin
DB00988 Dopamine
DB00997 Doxorubicin
DB01000 Cyclacillin
DB01032 Probenecid
DB01035 Procainamide
DB01053 Penicillin G
DB01059 Norfloxacin
DB01075 Diphenhydramine
DB01110 Miconazole
DB01137 Levofloxacin
DB01140 Cefadroxil
DB01151 Desipramine
DB01165 Ofloxacin
DB01208 Sparfloxacin
DB01234 Dexamethasone
DB01235 Levodopa
DB01333 Cefradine
DB01409 Tiotropium
DB01413 Cefepime
DB01577 Methamphetamine
DB01583 Liotrix
DB01686 N,N-dimethylarginine
DB01746 D-Leucine
DB01786 D-Alanine
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01833 L-2-Amino-4-(Guanidinooxy)Butyric Acid
DB01835 4r-Fluoro-N6-Ethanimidoyl-L-Lysine
DB01917 Putrescine
DB01983 2(S)-Amino-6-Boronohexanoic Acid
DB01997 3-Bromo-7-Nitroindazole
DB02011 N-(Phosphonoacetyl)-L-Ornithine
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02048 1,2,4-Triazole-Carboxamidine
DB02054 Gabaculine
DB02068 Delta-Amino Valeric Acid
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02141 S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB02207 7-Nitroindazole
DB02234 Ethylisothiourea
DB02267 Argininosuccinate
DB02335 2-Aminothiazoline
DB02381 Nor-N-Omega-Hydroxy-L-Arginine
DB02462 Thiocoumarin
DB02499 Dinor-N(Omega)-Hydroxy-L-Arginine
DB02530 Gamma(Amino)-Butyric Acid
DB02533 Aminoguanidine
DB02539 S-Ethylisothiourea
DB02556 D-Phenylalanine
DB02589 Se-Ethyl-Isoselenourea
DB02644 N-Omega-Propyl-L-Arginine
DB02689 S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02821 Canaline
DB02911 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
DB02952 Alpha-Aminoisobutyric Acid
DB02979 N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
DB02994 Hydroxydimethylarsine Oxide
DB03014 Heme
DB03065 7-Nitroindazole-2-Carboxamidine
DB03100 6-Nitroindazole
DB03107 Beta-Alanine
DB03128 Acetylcholine
DB03144 N-Omega-Hydroxy-L-Arginine
DB03225 D-Tryptophan
DB03271 7,8-Dihydro-L-Biopterin
DB03305 N5-Iminoethyl-L-Ornithine
DB03332 5,6-Cyclic-Tetrahydropteridine
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03519 2-Amino-Pentanoic Acid
DB03566 Spermidine
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03731 S-2-(Boronoethyl)-L-Cysteine
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03839 D-Tyrosine
DB03904 Urea
DB03910 S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB03918 6s-5,6,7,8-Tetrahydrobiopterin
DB03929 D-Serine
DB03953 L-Thiocitrulline
DB03963 S-(Dimethylarsenic)Cysteine
DB03974 L-Homoarginine
DB04018 S-Isopropyl-Isothiourea
DB04133 Degraded Cephaloridine
DB04185 Norvaline
DB04197 Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine
DB04223 Nitroarginine
DB04398 Lactic Acid
DB04400 7,8-Dihydrobiopterin
DB04454 Alpha-Aminobutyric Acid
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04534 5-Nitroindazole
DB04559 N-(Chlorophenyl)-N'-Hydroxyguanidine
DB04585 DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID
DB04630 Aldosterone
DB04648 S-propylamine-L-cysteine
DB06262 Droxidopa
DB06691 Mepyramine
DB06879 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE
DB06916 N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE
DB07001 (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
DB07002 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
DB07003 (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
DB07007 (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
DB07008 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
DB07011 (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
DB07029 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
DB07306 ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07318 N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07389 N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
DB07405 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08214 4-(1H-IMIDAZOL-1-YL)PHENOL
DB08750 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE
DB08795 Azidocillin
DB08814 Triflusal
DB08837 Tetraethylammonium
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