DT-Web

DB06691 - Mepyramine


Identification
Name Mepyramine
Accession Number DB06691
Type small molecule
Description Mepyramine (also known as pyrilamine) is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It is used in over-the-counter combination products for colds and menstrual symptoms.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 285.384
Groups approved
Monoisotopic Weight 285.184112373
Pharmacology
Indication Mepyramine is a first generation antihistamine used in treating allergies, ymptomatic relief of hypersensitivity reaction, and in pruritic skin disorders.
Mechanism of action Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of Mepyramine occur at the subcortical level of the CNS.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions
  • Avoid alcohol
  • Take with food

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Moriyama K, Liu J, Jang Y, Chae YJ, Wang Y, Mitchell J, Grond S, Han X, Xing Y, Xie GX, Pierce Palmer P: Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat. Inflamm Res. 2009 Dec;58(12):873-80. Epub 2009 Jun 21. - Pubmed
  • Chhabria MT, Patel VT, Rajan KS, Brahmkshatriya PS: Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7. - Pubmed
  • Mojtahedin A, Tamaddonfard E, Zanboori A: Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54. - Pubmed
  • Parsons ME, Ganellin CR: Histamine and its receptors. Br J Pharmacol. 2006 Jan;147 Suppl 1:S127-35. - Pubmed
  • Snowman AM, Snyder SH: Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8. - Pubmed
DTHybrid score 0.5201

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3257

Transporters


Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions Not Available
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.19
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions Not Available
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.2614

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1532
4200 Cytochrome P450 1A2 CYP1A2 0.0975
6145 Solute carrier family 22 member 1 SLC22A1 0.0879
1588 Multidrug resistance protein 1 ABCB1 0.0821
4757 Cytochrome P450 2C9 CYP2C9 0.0817
6016 Cytochrome P450 2C19 CYP2C19 0.0739
6144 Solute carrier family 22 member 2 SLC22A2 0.07
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0679
6147 Solute carrier family 22 member 3 SLC22A3 0.0536
6030 Cytochrome P450 2B6 CYP2B6 0.0525
4118 Cytochrome P450 3A5 CYP3A5 0.0519
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0512
4924 Cytochrome P450 2C8 CYP2C8 0.0507
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0476
556 Alpha-1A adrenergic receptor ADRA1A 0.0469
1729 Solute carrier family 22 member 6 SLC22A6 0.0457
6107 Cytochrome P450 3A7 CYP3A7 0.0447
6013 Cytochrome P450 2E1 CYP2E1 0.0438
502 5-hydroxytryptamine 2A receptor HTR2A 0.0428
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0427
6142 Solute carrier family 22 member 8 SLC22A8 0.0418
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0417
824 Sodium-dependent serotonin transporter SLC6A4 0.041
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0393
713 Sodium-dependent dopamine transporter SLC6A3 0.038
318 Alpha-2A adrenergic receptor ADRA2A 0.0359
6024 Cytochrome P450 1A1 CYP1A1 0.0349
831 D(2) dopamine receptor DRD2 0.0335
5718 Cytochrome P450 2A6 CYP2A6 0.0296
477 DNA topoisomerase 4 subunit A parC 0.0283
886 DNA topoisomerase 4 subunit A parC 0.0283
6226 DNA topoisomerase 4 subunit A parC 0.0283
404 DNA gyrase subunit A gyrA 0.0279
6224 DNA gyrase subunit A gyrA 0.0279
590 5-hydroxytryptamine 2C receptor HTR2C 0.0277
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0277
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0276
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0269
220 Sodium channel protein type 5 subunit alpha SCN5A 0.026
817 DNA topoisomerase 2-alpha TOP2A 0.0256
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0255
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.024
766 Beta-2 adrenergic receptor ADRB2 0.024
862 Multidrug resistance-associated protein 1 ABCC1 0.024
629 Alpha-2B adrenergic receptor ADRA2B 0.0231
23 D(1A) dopamine receptor DRD1 0.023
193 Beta-1 adrenergic receptor ADRB1 0.023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0227
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0221
632 Alpha-1B adrenergic receptor ADRA1B 0.0219
1341 Histamine H3 receptor HRH3 0.0218
378 Alpha-2C adrenergic receptor ADRA2C 0.0211
1024 Solute carrier family 22 member 11 SLC22A11 0.0207
2429 Putrescine-binding periplasmic protein potF 0.0206
449 Ornithine decarboxylase ODC1 0.0202
6106 Cytochrome P450 2C18 CYP2C18 0.0194
587 Serum albumin ALB 0.0191
638 D(3) dopamine receptor DRD3 0.0177
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0176
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
432 D(4) dopamine receptor DRD4 0.0171
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0166
159 Penicillin-binding protein 2B penA 0.0158
6121 Penicillin-binding protein 2B penA 0.0158
789 Alpha-1D adrenergic receptor ADRA1D 0.0153
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0145
3560 Gentamicin 3'-acetyltransferase aacC1 0.0143
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0138
3923 Cholinesterase BCHE 0.0136
124 Histamine H2 receptor HRH2 0.0136
738 Monocarboxylate transporter 1 SLC16A1 0.0135
3941 Amine oxidase [flavin-containing] A MAOA 0.0133
474 Acetylcholinesterase ACHE 0.0132
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0129
2472 Voltage-gated potassium channel kcsA 0.0128
6366 Voltage-gated potassium channel kcsA 0.0128
624 Guanidinoacetate N-methyltransferase GAMT 0.0128
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0124
6143 Solute carrier family 22 member 7 SLC22A7 0.0122
341 5-hydroxytryptamine 3 receptor HTR3A 0.0122
3947 Xanthine dehydrogenase/oxidase XDH 0.0115
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0115
20 Prostaglandin G/H synthase 1 PTGS1 0.0115
847 Mu-type opioid receptor OPRM1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
131 Synaptic vesicular amine transporter SLC18A2 0.0111
6151 Monocarboxylate transporter 10 SLC16A10 0.0111
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.011
776 Bile salt export pump ABCB11 0.0107
1636 Trace amine-associated receptor 1 TAAR1 0.0104
696 Kappa-type opioid receptor OPRK1 0.0104
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
1656 CYP2B protein CYP2B 0.0104
716 5-hydroxytryptamine 7 receptor HTR7 0.0101
3939 Amine oxidase [flavin-containing] B MAOB 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
1757 Myeloperoxidase MPO 0.0098
5126 Arginase rocF 0.0098
303 Diamine acetyltransferase 2 SAT2 0.0096
1317 Spermine synthase SMS 0.0096
623 Spermine oxidase SMOX 0.0096
465 Calmodulin CALM1 0.0095
163 D(1B) dopamine receptor DRD5 0.0094
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0093
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0093
467 Delta-type opioid receptor OPRD1 0.0092
885 5-hydroxytryptamine 1B receptor HTR1B 0.0092
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0092
1275 Estrogen sulfotransferase SULT1E1 0.009
499 Arginine decarboxylase ADC 0.0089
725 5-hydroxytryptamine 1D receptor HTR1D 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0087
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0087
123 Diamine acetyltransferase 1 SAT1 0.0086
577 Argininosuccinate lyase ASL 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
1256 5-hydroxytryptamine 6 receptor HTR6 0.0084
436 5-hydroxytryptamine 2B receptor HTR2B 0.0084
6182 Cytochrome P450 2J2 CYP2J2 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
6432 Transporter snf 0.0082
175 Thiamin pyrophosphokinase 1 TPK1 0.008
6168 Solute carrier family 22 member 16 SLC22A16 0.0079
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0078
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0076
740 Argininosuccinate synthase ASS1 0.0076
865 Argininosuccinate synthase ASS1 0.0076
2680 Argininosuccinate synthase argG 0.0076
3194 Argininosuccinate synthase argG 0.0076
976 Platelet glycoprotein IX GP9 0.0076
380 Cytochrome P450 17A1 CYP17A1 0.0076
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0075
164 Histamine H4 receptor HRH4 0.0074
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0073
6137 Multidrug resistance-associated protein 6 ABCC6 0.0073
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0073
551 Carnitine O-acetyltransferase CRAT 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
1898 Cytochrome P450 1B1 CYP1B1 0.0072
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0071
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.007
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0069
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0067
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0067
2300 Lysozyme E 0.0067
3633 Lysozyme R 0.0067
5597 Lysozyme 17 0.0067
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0067
6014 Cytochrome P450 2A13 CYP2A13 0.0066
4203 Histamine N-methyltransferase HNMT 0.0064
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0063
4604 Liver carboxylesterase 1 CES1 0.0063
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0062
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0061
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0061
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0061
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.006
7 Nitric oxide synthase, inducible NOS2 0.0059
1360 Sphingomyelin phosphodiesterase SMPD1 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0057
788 Creatine kinase M-type CKM 0.0057
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0057
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0056
291 Nitric-oxide synthase, endothelial NOS3 0.0056
5682 Ribonuclease pancreatic RNASE1 0.0056
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0055
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0055
769 High-affinity choline transporter 1 SLC5A7 0.0055
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0055
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0055
576 Choline O-acetyltransferase CHAT 0.0055
700 Choline dehydrogenase, mitochondrial CHDH 0.0055
861 Choline kinase alpha CHKA 0.0055
3927 Choline transporter-like protein 3 SLC44A3 0.0055
1686 Choline transporter-like protein 1 SLC44A1 0.0055
3922 Phospholipase D2 PLD2 0.0055
3926 Choline transporter-like protein 2 SLC44A2 0.0055
3925 Choline transporter-like protein 4 SLC44A4 0.0055
3924 Phospholipase D1 PLD1 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
528 5-hydroxytryptamine 1E receptor HTR1E 0.0054
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
751 Potassium channel subfamily K member 6 KCNK6 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0049
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0048
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0048
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0048
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0048
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0047
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0047
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0047
6031 Cytochrome P450 3A43 CYP3A43 0.0046
172 Potassium channel subfamily K member 1 KCNK1 0.0045
737 Mineralocorticoid receptor NR3C2 0.0045
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0045
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0045
2112 Toll-like receptor 9 TLR9 0.0044
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0043
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0043
1048 Protein S100-A13 S100A13 0.0043
2226 Protein S100-A12 S100A12 0.0043
2164 Multidrug resistance-associated protein 4 ABCC4 0.0042
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0041
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0041
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0041
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.004
2132 Protein S100-B S100B 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
3811 Cytochrome P450 19A1 CYP19A1 0.004
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
844 Epidermal growth factor receptor EGFR 0.0038
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0038
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0037
1074 Urokinase-type plasminogen activator PLAU 0.0035
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0034
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0034
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0033
1517 Beta-3 adrenergic receptor ADRB3 0.0033
6141 Sodium/bile acid cotransporter SLC10A1 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0031
146 Androgen receptor AR 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0029
6148 Multidrug resistance-associated protein 7 ABCC10 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0029
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0029
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0024
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0023
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
153 Dopamine beta-hydroxylase DBH 0.0022
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
3810 Catechol O-methyltransferase COMT 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0017
6136 Multidrug resistance-associated protein 5 ABCC5 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
1618 High affinity nerve growth factor receptor NTRK1 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
4120 NADPH--cytochrome P450 reductase POR 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0011
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.001
777 Tumor necrosis factor TNF 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
563 Thyroid peroxidase TPO 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
4773 Deoxycytidine kinase DCK 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
136 Estrogen receptor ESR1 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
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