DT-Web

DB00174 - L-Asparagine


Identification
Name L-Asparagine
Accession Number DB00174 (NUTR00015)
Type small molecule
Description A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 132.1179
Groups approved
Monoisotopic Weight 132.053492132
Pharmacology
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism of action Asparagine, a non-essential amino acid is important in the metabolism of toxic ammonia in the body through the action of asparagine synthase which attaches ammonia to aspartic acid in an amidation reaction. Asparagine is also used as a structural component in many proteins.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Neutral amino acid transporter B(0)
Name Neutral amino acid transporter B(0)
Gene Name SLC1A5
Pharmacological action unknown
Actions Not Available
References
  • Dun Y, Mysona B, Itagaki S, Martin-Studdard A, Ganapathy V, Smith SB: Functional and molecular analysis of D-serine transport in retinal Muller cells. Exp Eye Res. 2007 Jan;84(1):191-9. Epub 2006 Nov 13. - Pubmed
  • Oppedisano F, Pochini L, Galluccio M, Cavarelli M, Indiveri C: Reconstitution into liposomes of the glutamine/amino acid transporter from renal cell plasma membrane: functional characterization, kinetics and activation by nucleotides. Biochim Biophys Acta. 2004 Dec 15;1667(2):122-31. - Pubmed
DTHybrid score 0.7981
ASRGL1 protein
Name ASRGL1 protein
Gene Name ASRGL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7838
Probable asparaginyl-tRNA synthetase, mitochondrial
Name Probable asparaginyl-tRNA synthetase, mitochondrial
Gene Name NARS2
Pharmacological action unknown
Actions Not Available
References
  • Iwasaki W, Sekine S, Kuroishi C, Kuramitsu S, Shirouzu M, Yokoyama S: Structural basis of the water-assisted asparagine recognition by asparaginyl-tRNA synthetase. J Mol Biol. 2006 Jul 7;360(2):329-42. Epub 2006 May 15. - Pubmed
  • Roy H, Becker HD, Reinbolt J, Kern D: When contemporary aminoacyl-tRNA synthetases invent their cognate amino acid metabolism. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9837-42. Epub 2003 Jul 21. - Pubmed
DTHybrid score 0.923
System N amino acid transporter 1
Name System N amino acid transporter 1
Gene Name SLC38A3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8236
Asparagine synthetase [glutamine-hydrolyzing]
Name Asparagine synthetase [glutamine-hydrolyzing]
Gene Name ASNS
Pharmacological action unknown
Actions Not Available
References
  • Tesson AR, Soper TS, Ciustea M, Richards NG: Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli. Arch Biochem Biophys. 2003 May 1;413(1):23-31. - Pubmed
  • Fresquet V, Thoden JB, Holden HM, Raushel FM: Kinetic mechanism of asparagine synthetase from Vibrio cholerae. Bioorg Chem. 2004 Apr;32(2):63-75. - Pubmed
  • Chaffei C, Pageau K, Suzuki A, Gouia H, Ghorbel MH, Masclaux-Daubresse C: Cadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiol. 2004 Nov;45(11):1681-93. - Pubmed
  • Al Sarraj J, Vinson C, Thiel G: Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. Biol Chem. 2005 Sep;386(9):873-9. - Pubmed
  • Iwamoto S, Mihara K, Downing JR, Pui CH, Campana D: Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest. 2007 Apr;117(4):1049-57. Epub 2007 Mar 22. - Pubmed
DTHybrid score 0.6428
Asparaginyl-tRNA synthetase, cytoplasmic
Name Asparaginyl-tRNA synthetase, cytoplasmic
Gene Name NARS
Pharmacological action unknown
Actions Not Available
References
  • Iwasaki W, Sekine S, Kuroishi C, Kuramitsu S, Shirouzu M, Yokoyama S: Structural basis of the water-assisted asparagine recognition by asparaginyl-tRNA synthetase. J Mol Biol. 2006 Jul 7;360(2):329-42. Epub 2006 May 15. - Pubmed
  • Iwamoto S, Mihara K, Downing JR, Pui CH, Campana D: Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest. 2007 Apr;117(4):1049-57. Epub 2007 Mar 22. - Pubmed
DTHybrid score 0.9229

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.756

Predictions


Id Partner name Gene Name Score
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.1307
96 Histidine ammonia-lyase HAL 0.1307
6257 Histidine ammonia-lyase Not Available 0.1307
6536 Histidine ammonia-lyase hutH 0.1307
3 Histidine decarboxylase HDC 0.0998
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0938
1008 CTP synthase 1 CTPS 0.0726
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0726
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0726
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0726
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0726
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0726
3989 Glutaminyl-tRNA synthetase QARS 0.0726
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0726
917 Glutaminase kidney isoform, mitochondrial GLS 0.0661
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0661
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0661
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0661
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0661
5 Glutaminase liver isoform, mitochondrial GLS2 0.0661
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0661
5261 Phosphoribosylformylglycinamidine synthase purL 0.0661
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0643
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0547
2632 Adenylosuccinate synthetase purA 0.0546
3323 Adenylosuccinate synthetase purA 0.0546
3975 Adenylosuccinate synthetase ADSS 0.0546
4598 Adenylosuccinate synthetase Adss 0.0546
6817 Adenylosuccinate synthetase purA 0.0546
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0546
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0546
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0545
209 Aspartoacylase ASPA 0.0545
533 Aminoacylase-1 ACY1 0.0545
3979 Aspartoacylase-2 ACY3 0.0545
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0545
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0545
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0545
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0545
413 Amidophosphoribosyltransferase PPAT 0.0541
2515 Amidophosphoribosyltransferase purF 0.0541
3714 Amidophosphoribosyltransferase purF 0.0541
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.054
6 Coagulation factor XIII A chain F13A1 0.0514
740 Argininosuccinate synthase ASS1 0.0477
865 Argininosuccinate synthase ASS1 0.0477
2680 Argininosuccinate synthase argG 0.0477
3194 Argininosuccinate synthase argG 0.0477
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0462
3426 Glutamine synthetase glnA 0.0462
3987 Glutamine synthetase GLUL 0.0462
1671 Excitatory amino acid transporter 3 SLC1A1 0.0447
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
3877 Growth-inhibiting protein 18 GIG18 0.0427
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0419
1566 Corticoliberin CRH 0.0413
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0412
426 Aspartate aminotransferase, mitochondrial GOT2 0.039
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0294
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0293
2532 Pantoate--beta-alanine ligase panC 0.0285
199 Monocarboxylate transporter 8 SLC16A2 0.0258
6645 D-amino-acid oxidase DAO 0.0245
5925 Neuropeptide Y NPY 0.0231
5682 Ribonuclease pancreatic RNASE1 0.0214
763 Tyrosine aminotransferase TAT 0.0202
5493 Tyrosine aminotransferase Not Available 0.0202
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.017
5469 Head decoration protein shp 0.0168
2457 Bacillolysin nprS 0.016
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
534 Threonine synthase-like 1 THNSL1 0.0152
676 Tyrosine 3-monooxygenase TH 0.0149
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0132
33 Cystine/glutamate transporter SLC7A11 0.0127
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0119
349 Serine--pyruvate aminotransferase AGXT 0.0115
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
358 Cystathionine beta-synthase CBS 0.0106
5650 NimA-related protein DR_0842 0.0101
340 Apoptotic protease-activating factor 1 APAF1 0.01
738 Monocarboxylate transporter 1 SLC16A1 0.0099
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0099
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0098
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0093
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0093
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0093
733 Activin receptor type 1B ACVR1B 0.0093
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0093
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0093
825 Arsenical pump-driving ATPase ASNA1 0.0093
3435 Arsenical pump-driving ATPase arsA 0.0093
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0093
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0093
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0093
154 AFG3-like protein 2 AFG3L2 0.0093
395 ALK tyrosine kinase receptor Not Available 0.0093
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0087
500 Monocarboxylate transporter 4 SLC16A3 0.0087
489 Monocarboxylate transporter 2 SLC16A7 0.0086
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0084
169 Cysteine desulfurase, mitochondrial NFS1 0.0081
735 Alanine aminotransferase 1 GPT 0.008
3904 Alanine aminotransferase 2 GPT2 0.008
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0079
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0079
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0079
297 Adenylate cyclase type 1 ADCY1 0.0079
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
292 Activin receptor type-1 ACVR1 0.0076
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0076
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
184 L-serine dehydratase SDS 0.0076
431 Serine racemase SRR 0.0076
849 Activated CDC42 kinase 1 TNK2 0.0076
491 Serine palmitoyltransferase 1 SPTLC1 0.0076
727 Serine palmitoyltransferase 2 SPTLC2 0.0076
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0071
484 Tyrosine-protein kinase ABL2 ABL2 0.0069
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0069
594 Thyroxine-binding globulin SERPINA7 0.0066
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0065
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0062
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0062
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0062
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0062
1912 Excitatory amino acid transporter 1 SLC1A3 0.0062
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0062
4026 Aspartyl aminopeptidase DNPEP 0.0062
4020 Glutamyl aminopeptidase ENPEP 0.0062
664 Glutamate decarboxylase 2 GAD2 0.0062
3890 Glutamate decarboxylase 2 GAD2 0.0062
4016 Excitatory amino acid transporter 5 SLC1A7 0.0062
4019 Excitatory amino acid transporter 4 SLC1A6 0.0062
1047 Excitatory amino acid transporter 2 SLC1A2 0.0062
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0062
927 Metabotropic glutamate receptor 8 GRM8 0.0062
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0062
926 Metabotropic glutamate receptor 7 GRM7 0.0062
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0062
922 Glutamate receptor 4 GRIA4 0.0062
925 Metabotropic glutamate receptor 4 GRM4 0.0062
4018 Glutamate receptor delta-2 subunit GRID2 0.0062
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0062
4027 Glutamate receptor delta-1 subunit GRID1 0.0062
4017 5-oxoprolinase OPLAH 0.0062
6021 Adenosine kinase ADK 0.0062
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0061
758 Thyroid hormone receptor alpha THRA 0.0061
661 ADP/ATP translocase 1 SLC25A4 0.006
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
2452 Tryptophanyl-tRNA synthetase trpS 0.0056
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0056
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
1588 Multidrug resistance protein 1 ABCB1 0.0052
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0052
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0052
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0052
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.005
577 Argininosuccinate lyase ASL 0.0049
499 Arginine decarboxylase ADC 0.0049
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0048
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0048
665 Phosphoserine aminotransferase PSAT1 0.0048
4652 Phosphoserine aminotransferase serC 0.0048
420 Glutamate decarboxylase 1 GAD1 0.0048
3900 Glutamate decarboxylase 1 GAD1 0.0048
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
625 Glutamate carboxypeptidase 2 FOLH1 0.0048
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0047
6141 Sodium/bile acid cotransporter SLC10A1 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
916 Metabotropic glutamate receptor 1 GRM1 0.0045
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0044
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0044
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
923 Glutamate receptor 3 GRIA3 0.0043
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0042
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0042
435 Kynureninase KYNU 0.0041
4654 Kynureninase kynU 0.0041
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
776 Bile salt export pump ABCB11 0.0041
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
89 Cysteine sulfinic acid decarboxylase CSAD 0.004
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0039
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
705 Glutamate receptor 1 GRIA1 0.0037
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
868 Cystathionine gamma-lyase CTH 0.0035
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0035
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0034
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
6142 Solute carrier family 22 member 8 SLC22A8 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
432 D(4) dopamine receptor DRD4 0.003
587 Serum albumin ALB 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
638 D(3) dopamine receptor DRD3 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0027
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
23 D(1A) dopamine receptor DRD1 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
831 D(2) dopamine receptor DRD2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
556 Alpha-1A adrenergic receptor ADRA1A 0.002
4119 Cytochrome P450 2D6 CYP2D6 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0017
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0017
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
3884 SHMT2 protein SHMT2 0.0015
3901 SHMT2 protein SHMT2 0.0015
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0015
3879 Serine hydroxymethyltransferase 2 Not Available 0.0015
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0015
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0014
4924 Cytochrome P450 2C8 CYP2C8 0.0013
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