Partner ID 435
Name Kynureninase
Synonyms 1279
Gene name KYNU
General function Amino acid transport and metabolism
Specific function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3- hydroxyanthranilic acids (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity
Gene sequence + ...

ATGGAGCCTTCATCTCTTGAGCTGCCGGCTGACACAGTGCAGCGCATTGCGGCTGAACTCAAATGCCACCCAACGGATGAGAGGGTGGCTCTCCACCTAGATGAGGAAGATAAGCTGAGGCACTTCAGGGAGTGCTTTTATATTCCCAAAATACAGGATCTGCCTCCAGTTGATTTATCATTAGTGAATAAAGATGAAAATGCCATCTATTTCTTGGGAAATTCTCTTGGCCTTCAACCAAAAATGGTTAAAACATATCTTGAAGAAGAACTAGATAAGTGGGCCAAAATAGCAGCCTATGGTCATGAAGTGGGGAAGCGTCCTTGGATTACAGGAGATGAGAGTATTGTAGGCCTTATGAAGGACATTGTAGGAGCCAATGAGAAAGAAATAGCCCTAATGAATGCTTTGACTGTAAATTTACATCTTCTAATGTTATCATTTTTTAAGCCTACGCCAAAACGATATAAAATTCTTCTAGAAGCCAAAGCCTTCCCTTCTGATCATTATGCTATTGAGTCACAACTACAACTTCACGGACTTAACATTGAAGAAAGTATGCGGATGATAAAGCCAAGAGAGGGGGAAGAAACCTTAAGAATAGAGGATATCCTTGAAGTAATTGAGAAGGAAGGAGACTCAATTGCAGTGATCCTGTTCAGTGGGGTGCATTTTTACACTGGACAGCACTTTAATATTCCTGCCATCACAAAAGCTGGACAAGCGAAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAACCTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGGGTCTGTGGATTCCGAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAAAATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAACCAGTTGTGAACATAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAAAAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAATTTACCAATCTGCTCACTTCTATACTTGACTCTGCAGAAACAAAAAATTAG

Protein sequence + ...

MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

GO Classification
component
cell
intracellular
cytoplasm
function
hydrolase activity, acting on acid carbon-carbon bonds
pyridoxal phosphate binding
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
transferase activity
kynureninase activity
binding
vitamin binding
transferase activity, transferring nitrogenous groups
catalytic activity
transaminase activity
hydrolase activity
process
pyridine nucleotide biosynthesis
NAD biosynthesis
indolalkylamine metabolism
amino acid derivative metabolism
tryptophan metabolism
physiological process
biogenic amine metabolism
tryptophan catabolism
metabolism
cofactor metabolism
cellular metabolism
coenzyme metabolism
amino acid and derivative metabolism
coenzyme biosynthesis
See more information at   →   www.drugbank.ca
Id Name
DB00114 Pyridoxal Phosphate
DB00116 Tetrahydrofolic acid
DB00117 L-Histidine
DB00118 S-Adenosylmethionine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00122 Choline
DB00123 L-Lysine
DB00125 L-Arginine
DB00127 Spermine
DB00128 L-Aspartic Acid
DB00129 L-Ornithine
DB00130 L-Glutamine
DB00131 Adenosine monophosphate
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00172 L-Proline
DB00174 L-Asparagine
DB00190 Carbidopa
DB00260 Cycloserine
DB00279 Liothyronine
DB00313 Valproic Acid
DB00358 Mefloquine
DB00382 Tacrine
DB00483 Gallamine Triethiodide
DB00545 Pyridostigmine
DB00659 Acamprosate
DB00674 Galantamine
DB00677 Isoflurophate
DB00733 Pralidoxime
DB00780 Phenelzine
DB00805 Minaprine
DB00843 Donepezil
DB00875 Flupenthixol
DB00915 Amantadine
DB00944 Demecarium
DB00981 Physostigmine
DB00989 Rivastigmine
DB00996 Gabapentin
DB01010 Edrophonium
DB01055 Mimosine
DB01080 Vigabatrin
DB01122 Ambenonium
DB01199 Tubocurarine
DB01235 Levodopa
DB01245 Decamethonium
DB01364 Ephedrine
DB01400 Neostigmine
DB01583 Liotrix
DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione
DB01699 (4e)-4-Aminohex-4-Enoic Acid
DB01746 D-Leucine
DB01786 D-Alanine
DB01805 Monoisopropylphosphorylserine
DB01823 Beta-D-Glucopyranose Spirohydantoin
DB01843 3-Amino-8,9,10-Trihydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB01917 Putrescine
DB01928 Huperaine A
DB02007 Alpha-D-Glucose-6-Phosphate
DB02054 Gabaculine
DB02067 Triglu-5-Formyl-Tetrahydrofolate
DB02079 (Aminooxy)Acetic Acid
DB02089 CP-526423
DB02142 Pyridoxamine-5'-Phosphate
DB02166 Propidium
DB02209 Pyridoxine-5'-Phosphate
DB02226 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium
DB02320 1-N-Acetyl-Beta-D-Glucosamine
DB02328 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid
DB02343 3,6,9,12,15-Pentaoxaheptadecane
DB02348 Fluoro-Phosphite Ion
DB02379 Beta-D-Glucose
DB02404 1-Deoxy-1-Thio-Heptaethylene Glycol
DB02447 3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB02471 Nojirimycine Tetrazole
DB02519 Indirubin-5-Sulphonate
DB02556 D-Phenylalanine
DB02604 2-Deoxy-Glucose-6-Phosphate
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB02673 (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium
DB02719 C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide
DB02720 Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide
DB02750 S-(Methylmercury)-L-Cysteine
DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB02800 5-Hydroxymethylene-6-Hydrofolic Acid
DB02821 Canaline
DB02824 N-Pyridoxyl-Glycine-5-Monophosphate
DB02825 Methylphosphonic Acid Ester Group
DB02843 Alpha-D-Glucose-1-Phosphate
DB02845 Methylphosphinic Acid
DB02853 D-Proline
DB02952 Alpha-Aminoisobutyric Acid
DB02964 8,9,10-Trihydroxy-7-Hydroxymethyl-2-Thioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Decan-4-One
DB03005 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
DB03014 Heme
DB03067 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB03107 Beta-Alanine
DB03128 Acetylcholine
DB03133 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole
DB03218 N-Acetyl-N'-Beta-D-Glucopyranosyl Urea
DB03225 D-Tryptophan
DB03247 Riboflavin Monophosphate
DB03250 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole
DB03256 5-Formyl-5,6,7,8-Tetrahydrofolate
DB03283 beta-L-fucose
DB03286 C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide
DB03288 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide
DB03345 Beta-Mercaptoethanol
DB03354 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole
DB03359 M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
DB03383 5-Chloro-1h-Indole-2-Carboxylic Acid [1-(4-Fluorobenzyl)-2-(4-Hydroxypiperidin-1yl)-2-Oxoethyl]Amide
DB03392 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester
DB03479 8,9,10-Trihydroxy-7-Hydroxymethyl-3-Methyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB03496 Flavopiridol
DB03657 1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose
DB03740 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
DB03744 Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03835 N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide
DB03839 D-Tyrosine
DB03856 Alpha-Difluoromethylornithine
DB03928 Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol
DB03929 D-Serine
DB04013 1-Deoxy-1-Methoxycarbamido-Beta-D-Gluco-2-Heptulopyranosonamide
DB04021 MF268
DB04044 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB04055 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium
DB04074 Alpha-ketoisovalerate
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB04114 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine
DB04195 Heptulose-2-Phosphate
DB04217 L-2-amino-3-butynoic acid
DB04235 4-Amino Hexanoic Acid
DB04263 G418
DB04295 N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea
DB04299 Maleic Acid
DB04398 Lactic Acid
DB04522 Phosphonoserine
DB04544 1-Deoxy-1-Acetylamino-Beta-D-Gluco-2-Heptulopyranosonamide
DB04556 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
DB04566 Inosinic Acid
DB04614 (R)-tacrine(10)-hupyridone
DB04615 (S)-tacrine(10)-hupyridone
DB04616 TACRINE(8)-4-AMINOQUINOLINE
DB04617 (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
DB04642 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID
DB04643 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID
DB04644 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID
DB04645 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID
DB06262 Droxidopa
DB06986 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07066 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07069 3-Hydroxyhippuric acid
DB07315 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide
DB07395 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid
DB07396 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid
DB07544 N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
DB07555 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine
DB07701 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
DB07756 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL
DB07792 (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07793 (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07807 (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL
DB07822 (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE
DB07846 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE
DB07949 ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID
DB07950 1H-INDOL-3-YLACETIC ACID
DB07968 N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
DB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
DB08151 (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol
DB08167 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM
DB08322 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID
DB08357 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
DB08500 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08503 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08615 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
DB08835 Spaglumic Acid
DB08847 Hydroxyproline