DT-Web

DB02800 - 5-Hydroxymethylene-6-Hydrofolic Acid


Identification
Name 5-Hydroxymethylene-6-Hydrofolic Acid
Accession Number DB02800 (EXPT03049)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 473.4393
Groups experimental
Monoisotopic Weight 473.165896125
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7986
Hypothetical protein MG245 homolog
Name Hypothetical protein MG245 homolog
Gene Name MPN_348
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6522

Predictions


Id Partner name Gene Name Score
1649 Small inducible cytokine A2 CCL2 0.069
3193 Serine hydroxymethyltransferase glyA 0.0652
3342 Serine hydroxymethyltransferase glyA 0.0652
4823 L-allo-threonine aldolase TM_1744 0.0594
279 Tyrosinase TYR 0.0592
449 Ornithine decarboxylase ODC1 0.0481
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0209
3879 Serine hydroxymethyltransferase 2 Not Available 0.0209
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0209
3884 SHMT2 protein SHMT2 0.0206
3901 SHMT2 protein SHMT2 0.0206
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0141
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0141
3763 5,10-methylenetetrahydrofolate reductase metF 0.0141
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0141
5094 5,10-methylenetetrahydrofolate reductase metF 0.0141
59 AMT protein AMT 0.0141
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0141
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0134
207 Glutathione synthetase GSS 0.0114
5269 Glutathione synthetase gshB 0.0114
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0112
13 Aminomethyltransferase, mitochondrial AMT 0.0111
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0103
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0094
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0093
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0093
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0093
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0093
5304 UPF0166 protein TM_0021 TM_0021 0.0092
5287 Signaling protein Not Available 0.0092
5292 Putative partitioning protein TT_C1605 0.0092
3199 Phosphopantetheine adenylyltransferase coaD 0.0092
3543 Phosphopantetheine adenylyltransferase coaD 0.0092
3567 Phosphopantetheine adenylyltransferase coaD 0.0092
5289 Phosphopantetheine adenylyltransferase coaD 0.0092
4346 Polynucleotide kinase pseT 0.0092
5293 Shikimate kinase 2 aroL 0.0092
5288 Shikimate kinase aroK 0.0092
5281 Plasmid segregation protein parM parM 0.0092
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0092
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0092
5276 Chromosomal replication initiator protein dnaA dnaA 0.0092
5259 Transcriptional regulator ntrC1 0.0092
6699 Transcriptional regulator Cgl2612 0.0092
5266 Activator of hgdC 0.0092
5291 Glycogen synthase 1 glgA1 0.0092
2874 Nitrogenase iron protein 1 nifH1 0.0092
5283 D-alanine--D-alanine ligase B ddlB 0.0092
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0092
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0092
5299 D-alanine--D-alanine ligase ddl 0.0092
6598 D-alanine--D-alanine ligase ddl 0.0092
5284 Large T antigen Not Available 0.0092
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0092
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5277 Preprotein translocase subunit secA secA 0.0092
5264 DNA replication protein REP 0.0092
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0092
5285 Kinesin heavy chain KIF5B 0.0092
5315 Chaperone protein htpG htpG 0.0092
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0092
5261 Phosphoribosylformylglycinamidine synthase purL 0.0092
5308 Preprotein translocase secA 1 subunit secA1 0.0092
4106 Guanylate kinase GUK1 0.0081
4516 Guanylate kinase gmk 0.0081
413 Amidophosphoribosyltransferase PPAT 0.008
2515 Amidophosphoribosyltransferase purF 0.008
3714 Amidophosphoribosyltransferase purF 0.008
4837 Cag-alfa cag-alfa 0.008
4774 NTPase P4 Not Available 0.008
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.008
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.008
2270 Dephospho-CoA kinase coaE 0.008
2284 Adenylate kinase adk 0.008
2296 Adenylate kinase adk 0.008
2311 Adenylate kinase adk 0.008
2312 Adenylate kinase Not Available 0.008
3426 Glutamine synthetase glnA 0.008
3987 Glutamine synthetase GLUL 0.008
3390 Aminoglycoside 3'-phosphotransferase aphA 0.008
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.008
3175 Glutamate--cysteine ligase gshA 0.008
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.008
5265 FtsH ftsH 0.008
6277 Heat shock cognate 71 kDa protein HSPA8 0.008
5646 Galactokinase GALK1 0.008
4838 PMS1 protein homolog 2 PMS2 0.008
5302 TrwB trwB 0.008
5189 Trimethylamine dehydrogenase tmd 0.008
4839 DNA polymerase III subunit tau dnaX 0.008
3917 Methylenetetrahydrofolate reductase MTHFR 0.008
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0078
349 Serine--pyruvate aminotransferase AGXT 0.0077
2683 Mono-ADP-ribosyltransferase C3 C3 0.0074
2390 Nonsecretory ribonuclease RNASE2 0.0074
2922 Glycerol kinase glpK 0.0074
5271 Focal adhesion kinase 1 PTK2 0.0074
5312 Kinesin-like protein KIF1A KIF1A 0.0074
5300 Antigen peptide transporter 1 TAP1 0.0073
340 Apoptotic protease-activating factor 1 APAF1 0.0073
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0071
4057 Glycine N-acyltransferase GLYAT 0.0071
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0071
1466 Glycyl-tRNA synthetase GARS 0.0071
4056 N-arachidonyl glycine receptor GPR18 0.0071
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0071
4061 Peroxisomal sarcosine oxidase PIPOX 0.0071
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0071
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0071
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0071
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0071
3669 Ribokinase rbsK 0.007
2371 Pantothenate kinase coaA 0.007
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.007
2892 Acetylglutamate kinase argB 0.007
3550 Acetylglutamate kinase argB 0.007
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.007
1881 Hexokinase-1 HK1 0.007
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.007
2615 Chemotaxis protein cheA cheA 0.007
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.007
825 Arsenical pump-driving ATPase ASNA1 0.007
3435 Arsenical pump-driving ATPase arsA 0.007
408 Riboflavin kinase RFK 0.007
2282 Protein recA recA 0.007
2315 Protein recA recA 0.007
2332 Protein recA recA 0.007
5263 Protein recA recA 0.007
2727 S-adenosylmethionine synthetase metK 0.0067
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0067
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0067
788 Creatine kinase M-type CKM 0.0067
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0067
2334 Dethiobiotin synthetase bioD 0.0065
6555 Dethiobiotin synthetase bioD 0.0065
2697 Uridine-cytidine kinase 2 UCK2 0.0065
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0065
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0063
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0063
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0063
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0063
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0062
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0061
48 Pyridoxal kinase PDXK 0.006
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.006
6395 Myosin-14 MYH14 0.0059
2091 Endoplasmin HSP90B1 0.0059
702 UMP-CMP kinase CMPK1 0.0059
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0059
2251 Thymidylate kinase tmk 0.0058
2254 Thymidylate kinase DTYMK 0.0058
3522 Thymidylate kinase tmk 0.0058
1422 Serine/threonine-protein kinase 6 AURKA 0.0057
62 Glycine receptor subunit beta GLRB 0.0057
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0057
411 Glycine N-methyltransferase GNMT 0.0057
3379 Kinesin-like protein KIF11 KIF11 0.0056
383 Glycine amidinotransferase, mitochondrial GATM 0.0055
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0055
3822 Actin, alpha skeletal muscle ACTA1 0.0054
504 Mast/stem cell growth factor receptor KIT 0.0054
509 Thymidine kinase TK 0.0052
570 Thymidine kinase TK 0.0052
2559 Thymidine kinase TK 0.0052
3430 Thymidine kinase tdk 0.0052
3518 Thymidine kinase TK 0.0052
5301 Thymidine kinase tdk 0.0052
5771 Thymidine kinase ORF36 0.0052
7009 Thymidine kinase ORF36 0.0052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
5294 Nucleoside diphosphate kinase A NME1 0.0051
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.005
593 Proton-coupled amino acid transporter 1 SLC36A1 0.005
1721 Glycogen synthase kinase-3 beta GSK3B 0.005
461 Glycine receptor subunit alpha-3 GLRA3 0.0048
820 Glycine receptor subunit alpha-2 GLRA2 0.0048
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0048
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
5682 Ribonuclease pancreatic RNASE1 0.0047
4773 Deoxycytidine kinase DCK 0.0047
3880 Serine hydroxymethyltransferase 1 Not Available 0.0044
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0044
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0043
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
3911 Uncharacterized protein C20orf38 SPTLC3 0.0036
306 Pyridoxal phosphate phosphatase PDXP 0.0036
3881 Selenocysteine lyase variant Not Available 0.0036
3887 Phosphorylase PYGB 0.0036
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0036
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0036
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0036
3883 Ornithine aminotransferase variant Not Available 0.0036
3906 Serine dehydratase-like SDSL 0.0036
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0036
3891 Putative L-Dopa decarboxylase DDC 0.0036
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0036
664 Glutamate decarboxylase 2 GAD2 0.0036
3890 Glutamate decarboxylase 2 GAD2 0.0036
3886 Migration-inducing protein 4 ALAS1 0.0036
3878 GAD1 protein GAD1 0.0036
3893 DDC protein DDC 0.0036
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0036
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0036
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0036
3894 KIAA0251 protein PDXDC1 0.0036
3875 Glycogen phosphorylase, brain form PYGB 0.0036
3882 Brain glycogen phosphorylase variant Not Available 0.0036
3905 Molybdenum cofactor sulfurase MOCOS 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.003
184 L-serine dehydratase SDS 0.003
431 Serine racemase SRR 0.003
491 Serine palmitoyltransferase 1 SPTLC1 0.003
89 Cysteine sulfinic acid decarboxylase CSAD 0.003
727 Serine palmitoyltransferase 2 SPTLC2 0.003
534 Threonine synthase-like 1 THNSL1 0.003
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.003
665 Phosphoserine aminotransferase PSAT1 0.003
4652 Phosphoserine aminotransferase serC 0.003
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.003
420 Glutamate decarboxylase 1 GAD1 0.003
3900 Glutamate decarboxylase 1 GAD1 0.003
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.003
3 Histidine decarboxylase HDC 0.003
499 Arginine decarboxylase ADC 0.003
435 Kynureninase KYNU 0.003
4654 Kynureninase kynU 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
472 Ornithine aminotransferase, mitochondrial OAT 0.0028
169 Cysteine desulfurase, mitochondrial NFS1 0.0028
868 Cystathionine gamma-lyase CTH 0.0028
3877 Growth-inhibiting protein 18 GIG18 0.0027
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0027
426 Aspartate aminotransferase, mitochondrial GOT2 0.0027
358 Cystathionine beta-synthase CBS 0.0027
735 Alanine aminotransferase 1 GPT 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
763 Tyrosine aminotransferase TAT 0.0026
5493 Tyrosine aminotransferase Not Available 0.0026
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0025
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0025
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0023
10 Glycogen phosphorylase, liver form PYGL 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
1152 Glycogen phosphorylase, muscle form PYGM 0.0018
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