DT-Web

DB00875 - Flupenthixol


Identification
Name Flupenthixol
Accession Number DB00875 (APRD00388)
Type small molecule
Description Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 436.533
Groups approved
Monoisotopic Weight 436.179618801
Pharmacology
Indication For use in the treatment of schizophrenia and depression
Mechanism of action Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.
Absorption Fairly slow and incomplete after oral administration
Protein binding Highly bound to plasma proteins (>95%)
Biotransformation Mainly hepatic
Route of elimination Not Available
Toxicity LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Rivastigmine Possible antagonism of action
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Flupenthixol, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimethobenzamide Trimethobenzamide and Flupenthixol, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine Triprolidine and Flupenthixol, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Flupenthixol, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take with food to reduce irritation.
  • Avoid alcohol.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Ogren SO, Hall H, Kohler C, Magnusson O, Lindbom LO, Angeby K, Florvall L: Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. Eur J Pharmacol. 1984 Jul 20;102(3-4):459-74. - Pubmed
  • Arnt J: Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine. Eur J Pharmacol. 1995 Sep 5;283(1-3):55-62. - Pubmed
  • Huettl P, Gerhardt GA, Browning MD, Masserano JM: Effects of dopamine receptor agonists and antagonists on catecholamine release in bovine chromaffin cells. J Pharmacol Exp Ther. 1991 May;257(2):567-74. - Pubmed
  • Nilsson CL, Ekman A, Hellstrand M, Eriksson E: Inverse agonism at dopamine D2 receptors. Haloperidol-induced prolactin release from GH4C1 cells transfected with the human D2 receptor is antagonized by R(-)-n-propylnorapomorphine, raclopride, and phenoxybenzamine. Neuropsychopharmacology. 1996 Jul;15(1):53-61. - Pubmed
  • Reimold M, Solbach C, Noda S, Schaefer JE, Bartels M, Beneke M, Machulla HJ, Bares R, Glaser T, Wormstall H: Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol. Psychopharmacology (Berl). 2007 Feb;190(2):241-9. Epub 2006 Nov 17. - Pubmed
DTHybrid score 0.4911
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Reimold M, Solbach C, Noda S, Schaefer JE, Bartels M, Beneke M, Machulla HJ, Bares R, Glaser T, Wormstall H: Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol. Psychopharmacology (Berl). 2007 Feb;190(2):241-9. Epub 2006 Nov 17. - Pubmed
DTHybrid score 0.3694
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Cai G, Gurdal H, Smith C, Wang HY, Friedman E: Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Mol Pharmacol. 1999 Nov;56(5):989-96. - Pubmed
  • Reimold M, Solbach C, Noda S, Schaefer JE, Bartels M, Beneke M, Machulla HJ, Bares R, Glaser T, Wormstall H: Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol. Psychopharmacology (Berl). 2007 Feb;190(2):241-9. Epub 2006 Nov 17. - Pubmed
DTHybrid score 0.3751
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4252
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
DTHybrid score 0.4728

Enzymes


Aromatic-L-amino-acid decarboxylase
Name Aromatic-L-amino-acid decarboxylase
Gene Name DDC
Actions inducer
References
  • -
  • Zhu MY, Juorio AV, Paterson IA, Boulton AA: Regulation of aromatic L-amino acid decarboxylase in rat striatal synaptosomes: effects of dopamine receptor agonists and antagonists. Br J Pharmacol. 1994 May;112(1):23-30. - Pubmed
DTHybrid score 0.3861

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Hait WN, Gesmonde JF, Murren JR, Yang JM, Chen HX, Reiss M: Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells. Biochem Pharmacol. 1993 Jan 26;45(2):401-6. - Pubmed
  • Dey S, Hafkemeyer P, Pastan I, Gottesman MM: A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol. Biochemistry. 1999 May 18;38(20):6630-9. - Pubmed
  • Hafkemeyer P, Licht T, Pastan I, Gottesman MM: Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. Hum Gene Ther. 2000 Mar 1;11(4):555-65. - Pubmed
  • Yang JM, Vassil A, Hait WN: Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells. Biochem Pharmacol. 2002 Mar 1;63(5):959-66. - Pubmed
  • Ford JM, Bruggemann EP, Pastan I, Gottesman MM, Hait WN: Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines. Cancer Res. 1990 Mar 15;50(6):1748-56. - Pubmed
  • Ford JM, Yang JM, Hait WN: Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice. Cancer Res. 1991 Jan 1;51(1):67-72. - Pubmed
DTHybrid score 0.3091

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2389
4512 Cytochrome P450 3A4 CYP3A4 0.2018
318 Alpha-2A adrenergic receptor ADRA2A 0.1967
617 Muscarinic acetylcholine receptor M2 CHRM2 0.182
632 Alpha-1B adrenergic receptor ADRA1B 0.1767
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1681
320 5-hydroxytryptamine 1A receptor HTR1A 0.1504
590 5-hydroxytryptamine 2C receptor HTR2C 0.1442
638 D(3) dopamine receptor DRD3 0.1357
432 D(4) dopamine receptor DRD4 0.1312
492 Histamine H1 receptor HRH1 0.1237
4200 Cytochrome P450 1A2 CYP1A2 0.123
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1198
163 D(1B) dopamine receptor DRD5 0.1138
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1098
629 Alpha-2B adrenergic receptor ADRA2B 0.1067
378 Alpha-2C adrenergic receptor ADRA2C 0.1024
789 Alpha-1D adrenergic receptor ADRA1D 0.099
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0894
436 5-hydroxytryptamine 2B receptor HTR2B 0.081
6016 Cytochrome P450 2C19 CYP2C19 0.0791
6145 Solute carrier family 22 member 1 SLC22A1 0.0726
4757 Cytochrome P450 2C9 CYP2C9 0.0713
4118 Cytochrome P450 3A5 CYP3A5 0.0713
807 D-alanine--D-alanine ligase A ddlA 0.0692
894 Alanine racemase alr 0.0691
2453 Alanine racemase alr 0.0691
824 Sodium-dependent serotonin transporter SLC6A4 0.0688
725 5-hydroxytryptamine 1D receptor HTR1D 0.0679
716 5-hydroxytryptamine 7 receptor HTR7 0.0674
885 5-hydroxytryptamine 1B receptor HTR1B 0.0608
587 Serum albumin ALB 0.0545
6107 Cytochrome P450 3A7 CYP3A7 0.0528
4924 Cytochrome P450 2C8 CYP2C8 0.0518
6013 Cytochrome P450 2E1 CYP2E1 0.0504
3923 Cholinesterase BCHE 0.0496
1256 5-hydroxytryptamine 6 receptor HTR6 0.0479
6030 Cytochrome P450 2B6 CYP2B6 0.047
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0452
193 Beta-1 adrenergic receptor ADRB1 0.045
766 Beta-2 adrenergic receptor ADRB2 0.0403
131 Synaptic vesicular amine transporter SLC18A2 0.0385
713 Sodium-dependent dopamine transporter SLC6A3 0.0383
6144 Solute carrier family 22 member 2 SLC22A2 0.0382
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0373
6151 Monocarboxylate transporter 10 SLC16A10 0.0346
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0324
3941 Amine oxidase [flavin-containing] A MAOA 0.0313
465 Calmodulin CALM1 0.0308
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0294
6024 Cytochrome P450 1A1 CYP1A1 0.0282
694 Matrix protein 2 M 0.0277
124 Histamine H2 receptor HRH2 0.0268
3939 Amine oxidase [flavin-containing] B MAOB 0.0261
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0238
90 Tryptophan 5-hydroxylase 2 TPH2 0.0238
528 5-hydroxytryptamine 1E receptor HTR1E 0.0228
94 5-hydroxytryptamine 4 receptor HTR4 0.0222
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0218
341 5-hydroxytryptamine 3 receptor HTR3A 0.0211
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0206
174 Sigma 1-type opioid receptor SIGMAR1 0.02
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0199
765 Indoleamine 2,3-dioxygenase IDO1 0.0198
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0191
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0188
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0186
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0185
474 Acetylcholinesterase ACHE 0.0183
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0176
5718 Cytochrome P450 2A6 CYP2A6 0.0176
134 Tryptophan 5-hydroxylase 1 TPH1 0.0175
6012 Tryptophan 2,3-dioxygenase TDO2 0.0173
2452 Tryptophanyl-tRNA synthetase trpS 0.0173
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0169
199 Monocarboxylate transporter 8 SLC16A2 0.0162
1517 Beta-3 adrenergic receptor ADRB3 0.0157
862 Multidrug resistance-associated protein 1 ABCC1 0.0157
118 Organic cation/carnitine transporter 2 SLC22A5 0.0157
828 Phenylalanine-4-hydroxylase PAH 0.0155
3109 Phenylalanine-4-hydroxylase phhA 0.0155
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0155
923 Glutamate receptor 3 GRIA3 0.0149
1656 CYP2B protein CYP2B 0.0142
6147 Solute carrier family 22 member 3 SLC22A3 0.0142
776 Bile salt export pump ABCB11 0.0139
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0139
3426 Glutamine synthetase glnA 0.0136
3987 Glutamine synthetase GLUL 0.0136
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0135
6106 Cytochrome P450 2C18 CYP2C18 0.0131
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0127
833 Organic cation/carnitine transporter 1 SLC22A4 0.0121
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0116
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0115
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0108
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0108
871 Glucocorticoid receptor NR3C1 0.0099
20 Prostaglandin G/H synthase 1 PTGS1 0.0097
380 Cytochrome P450 17A1 CYP17A1 0.0097
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0095
921 Glutamate receptor 2 GRIA2 0.0094
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0093
1898 Cytochrome P450 1B1 CYP1B1 0.0092
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0091
6432 Transporter snf 0.009
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0089
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0089
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0089
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0088
6859 Protein S100-A4 S100A4 0.0088
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0086
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0084
1729 Solute carrier family 22 member 6 SLC22A6 0.008
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0075
696 Kappa-type opioid receptor OPRK1 0.0074
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0073
4120 NADPH--cytochrome P450 reductase POR 0.0073
136 Estrogen receptor ESR1 0.0072
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0071
6138 Multidrug resistance protein 3 ABCB4 0.0071
3947 Xanthine dehydrogenase/oxidase XDH 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
817 DNA topoisomerase 2-alpha TOP2A 0.0065
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0061
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.006
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.006
467 Delta-type opioid receptor OPRD1 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.006
6143 Solute carrier family 22 member 7 SLC22A7 0.0059
3811 Cytochrome P450 19A1 CYP19A1 0.0058
2129 Sucrase-isomaltase, intestinal SI 0.0057
1192 Sulfotransferase 1A1 SULT1A1 0.0055
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0055
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0054
4604 Liver carboxylesterase 1 CES1 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
844 Epidermal growth factor receptor EGFR 0.005
731 HIV-1 protease HIV-1 protease 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
847 Mu-type opioid receptor OPRM1 0.0048
2616 Ganglioside GM2 activator GM2A 0.0047
164 Histamine H4 receptor HRH4 0.0046
2164 Multidrug resistance-associated protein 4 ABCC4 0.0045
427 Substance-P receptor TACR1 0.0045
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0045
6137 Multidrug resistance-associated protein 6 ABCC6 0.0045
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0044
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0044
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0044
290 Prostaglandin G/H synthase 2 PTGS2 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0042
869 Estrogen receptor beta ESR2 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
614 Progesterone receptor PGR 0.0041
198 Sodium channel protein type 10 subunit alpha SCN10A 0.004
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.004
1636 Trace amine-associated receptor 1 TAAR1 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0039
3893 DDC protein DDC 0.0038
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0038
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0037
1618 High affinity nerve growth factor receptor NTRK1 0.0037
3891 Putative L-Dopa decarboxylase DDC 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
504 Mast/stem cell growth factor receptor KIT 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
3810 Catechol O-methyltransferase COMT 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
153 Dopamine beta-hydroxylase DBH 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
1024 Solute carrier family 22 member 11 SLC22A11 0.0031
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0031
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0031
3911 Uncharacterized protein C20orf38 SPTLC3 0.0031
3906 Serine dehydratase-like SDSL 0.0031
3881 Selenocysteine lyase variant Not Available 0.0031
3887 Phosphorylase PYGB 0.0031
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0031
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0031
3878 GAD1 protein GAD1 0.0031
3883 Ornithine aminotransferase variant Not Available 0.0031
306 Pyridoxal phosphate phosphatase PDXP 0.0031
664 Glutamate decarboxylase 2 GAD2 0.0031
3890 Glutamate decarboxylase 2 GAD2 0.0031
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0031
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0031
3880 Serine hydroxymethyltransferase 1 Not Available 0.0031
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0031
3894 KIAA0251 protein PDXDC1 0.0031
3875 Glycogen phosphorylase, brain form PYGB 0.0031
3882 Brain glycogen phosphorylase variant Not Available 0.0031
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0031
3886 Migration-inducing protein 4 ALAS1 0.0031
3905 Molybdenum cofactor sulfurase MOCOS 0.0031
904 Glutathione S-transferase P GSTP1 0.003
756 Sex hormone-binding globulin SHBG 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
3 Histidine decarboxylase HDC 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0026
727 Serine palmitoyltransferase 2 SPTLC2 0.0026
491 Serine palmitoyltransferase 1 SPTLC1 0.0026
184 L-serine dehydratase SDS 0.0026
431 Serine racemase SRR 0.0026
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0026
228 Beta platelet-derived growth factor receptor PDGFRB 0.0026
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0026
89 Cysteine sulfinic acid decarboxylase CSAD 0.0026
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
534 Threonine synthase-like 1 THNSL1 0.0026
420 Glutamate decarboxylase 1 GAD1 0.0026
3900 Glutamate decarboxylase 1 GAD1 0.0026
665 Phosphoserine aminotransferase PSAT1 0.0026
4652 Phosphoserine aminotransferase serC 0.0026
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0026
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0026
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0026
499 Arginine decarboxylase ADC 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0026
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
1374 Natriuretic peptides B NPPB 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
146 Androgen receptor AR 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
435 Kynureninase KYNU 0.0024
4654 Kynureninase kynU 0.0024
763 Tyrosine aminotransferase TAT 0.0024
5493 Tyrosine aminotransferase Not Available 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
169 Cysteine desulfurase, mitochondrial NFS1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
3877 Growth-inhibiting protein 18 GIG18 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
358 Cystathionine beta-synthase CBS 0.0023
3884 SHMT2 protein SHMT2 0.0023
3901 SHMT2 protein SHMT2 0.0023
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0023
3879 Serine hydroxymethyltransferase 2 Not Available 0.0023
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0023
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0023
472 Ornithine aminotransferase, mitochondrial OAT 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
373 Transthyretin TTR 0.0023
426 Aspartate aminotransferase, mitochondrial GOT2 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0022
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0022
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0022
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0022
868 Cystathionine gamma-lyase CTH 0.0022
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
468 Cytochrome P450 4A11 CYP4A11 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0021
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
349 Serine--pyruvate aminotransferase AGXT 0.002
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.002
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.002
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.002
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.002
449 Ornithine decarboxylase ODC1 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
183 Vascular endothelial growth factor A VEGFA 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0018
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
10 Glycogen phosphorylase, liver form PYGL 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
702 UMP-CMP kinase CMPK1 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
165 FL cytokine receptor FLT3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1152 Glycogen phosphorylase, muscle form PYGM 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
3957 Adenosine deaminase ADA 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1757 Myeloperoxidase MPO 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6020 Aldehyde oxidase AOX1 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
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