DT-Web

DB00539 - Toremifene


Identification
Name Toremifene
Accession Number DB00539 (APRD00391)
Type small molecule
Description A first generation nonsteroidal selective estrogen receptor modulator (SERM) that is structurally related to tamoxifen. Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 405.96
Groups approved
Monoisotopic Weight 405.18594223
Pharmacology
Indication For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.
Mechanism of action Toremifene is a nonsteroidal triphenylethylene derivative. Toremifene binds to estrogen receptors and may exert estrogenic, antiestrogenic, or both activities, depending upon the duration of treatment, animal species, gender, target organ, or endpoint selected. The antitumor effect of toremifene in breast cancer is believed to be mainly due to its antiestrogenic effects, in other words, its ability to compete with estrogen for binding sites in the cancer, blocking the growth-stimulating effects of estrogen in the tumor. Toremifene may also inhibit tumor growth through other mechanisms, such as induction of apoptosis, regulation of oncogene expression, and growth factors.
Absorption Well absorbed
Protein binding Toremifen is primarily bound to albumin (92%), 2% bound to ?1-acid glycoprotein, and 6% bound to ?1-globulin in the serum.
Biotransformation Hepatic. Mainly by CYP3A4 to N-demethyltoremifene, which exhibits antiestrogenic effects but has weak antitumor potency in vivo.
Route of elimination Toremifene is extensively metabolized, principally by CYP3A4 to N-demethyltoremifene, which is also antiestrogenic but with weak in vivo antitumor potency.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abarelix Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Amiodarone Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Amitriptyline Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Amoxapine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Apomorphine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Arsenic trioxide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Asenapine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Chlorpromazine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Cisapride Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Clarithromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Clomipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Conivaptan CYP3A4 Inhibitors (Strong) such as conivaptan may enhance the adverse/toxic effect of Toremifene. CYP3A4 Inhibitors (Strong) may increase the serum concentration of Toremifene. Concurrent use of toremifene with strong CYP3A4 inhibitors should be avoided.
Dasatinib Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Desipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Disopyramide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Dofetilide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Dolasetron Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Domperidone Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Doxepin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Droperidol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Erythromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Etravirine Toremifene, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Flecainide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Fluconazole Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Fluoxetine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Flupenthixol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Foscarnet Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Gatifloxacin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Halofantrine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Haloperidol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Ibutilide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Imipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Indapamide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Isradipine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Lapatinib Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Levofloxacin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Loxapine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Mefloquine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Mesoridazine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Methadone Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Moxifloxacin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Nilotinib May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Norfloxacin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Nortriptyline Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Octreotide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Pazopanib Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Pentamidine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Perflutren Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Pimozide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Probucol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Procainamide Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Propafenone Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Protriptyline Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Quetiapine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Quinidine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Quinine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Ranolazine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Rifabutin The rifamycin decreases the effect of anti-estrogen
Rifampin The rifamycin decreases the effect of anti-estrogen
Risperidone Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Sotalol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Sparfloxacin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Sunitinib Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tacrolimus Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Telithromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tetrabenazine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Thioridazine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Thiothixene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Voriconazole Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Vorinostat Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Food Interactions Not Available

Targets


Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions modulator
References
  • Locci P, Bellocchio S, Lilli C, Marinucci L, Cagini L, Baroni T, Giustozzi G, Balducci C, Becchetti E: Synthesis and secretion of transforming growth factor-beta1 by human desmoid fibroblast cell line and its modulation by toremifene. J Interferon Cytokine Res. 2001 Nov;21(11):961-70. - Pubmed
  • Liu X, Pisha E, Tonetti DA, Yao D, Li Y, Yao J, Burdette JE, Bolton JL: Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites. Chem Res Toxicol. 2003 Jul;16(7):832-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Jones KL, Buzdar AU: A review of adjuvant hormonal therapy in breast cancer. Endocr Relat Cancer. 2004 Sep;11(3):391-406. - Pubmed
  • Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB: Selective estrogen receptor modulators: an update on recent clinical findings. Obstet Gynecol Surv. 2008 Mar;63(3):163-81. - Pubmed
  • Gennari L, Merlotti D, Valleggi F, Martini G, Nuti R: Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development. Drugs Aging. 2007;24(5):361-79. - Pubmed
  • Lewis-Wambi JS, Jordan VC: Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs). Breast Dis. 2005-2006;24:93-105. - Pubmed
  • Ariazi EA, Ariazi JL, Cordera F, Jordan VC: Estrogen receptors as therapeutic targets in breast cancer. Curr Top Med Chem. 2006;6(3):181-202. - Pubmed
  • Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA: Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy. Expert Opin Investig Drugs. 2006 Mar;15(3):293-305. - Pubmed
  • Goldstein LJ: Controversies in adjuvant endocrine treatment of premenopausal women. Clin Breast Cancer. 2006 Feb;6 Suppl 2:S36-40. - Pubmed
  • Smith MR: Treatment-related osteoporosis in men with prostate cancer. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6315s-6319s. - Pubmed
DTHybrid score 0.7133

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA: Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy. Expert Opin Investig Drugs. 2006 Mar;15(3):293-305. - Pubmed
  • Kivisto KT, Villikka K, Nyman L, Anttila M, Neuvonen PJ: Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin. Clin Pharmacol Ther. 1998 Dec;64(6):648-54. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4595
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2317
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.354

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Rao US, Fine RL, Scarborough GA: Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. - Pubmed
DTHybrid score 0.3301

Predictions


Id Partner name Gene Name Score
6241 Nuclear receptor coactivator 2 NCOA2 0.2319
4119 Cytochrome P450 2D6 CYP2D6 0.1816
4757 Cytochrome P450 2C9 CYP2C9 0.1654
6016 Cytochrome P450 2C19 CYP2C19 0.1443
4118 Cytochrome P450 3A5 CYP3A5 0.1375
4924 Cytochrome P450 2C8 CYP2C8 0.1247
6013 Cytochrome P450 2E1 CYP2E1 0.1019
6030 Cytochrome P450 2B6 CYP2B6 0.0999
869 Estrogen receptor beta ESR2 0.0901
6107 Cytochrome P450 3A7 CYP3A7 0.0896
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0757
614 Progesterone receptor PGR 0.0744
5718 Cytochrome P450 2A6 CYP2A6 0.0688
3811 Cytochrome P450 19A1 CYP19A1 0.0579
587 Serum albumin ALB 0.0575
1898 Cytochrome P450 1B1 CYP1B1 0.0508
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.048
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0436
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0398
862 Multidrug resistance-associated protein 1 ABCC1 0.0384
20 Prostaglandin G/H synthase 1 PTGS1 0.0378
871 Glucocorticoid receptor NR3C1 0.0375
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0365
6145 Solute carrier family 22 member 1 SLC22A1 0.0347
492 Histamine H1 receptor HRH1 0.0345
1729 Solute carrier family 22 member 6 SLC22A6 0.0314
556 Alpha-1A adrenergic receptor ADRA1A 0.0309
776 Bile salt export pump ABCB11 0.0302
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0294
831 D(2) dopamine receptor DRD2 0.0283
318 Alpha-2A adrenergic receptor ADRA2A 0.0282
6144 Solute carrier family 22 member 2 SLC22A2 0.0281
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0276
824 Sodium-dependent serotonin transporter SLC6A4 0.0273
502 5-hydroxytryptamine 2A receptor HTR2A 0.0266
6106 Cytochrome P450 2C18 CYP2C18 0.0262
36 Insulin receptor INSR 0.0258
193 Beta-1 adrenergic receptor ADRB1 0.0257
290 Prostaglandin G/H synthase 2 PTGS2 0.0245
817 DNA topoisomerase 2-alpha TOP2A 0.0242
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0236
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0226
756 Sex hormone-binding globulin SHBG 0.0224
766 Beta-2 adrenergic receptor ADRB2 0.0221
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0216
468 Cytochrome P450 4A11 CYP4A11 0.0209
118 Organic cation/carnitine transporter 2 SLC22A5 0.0208
23 D(1A) dopamine receptor DRD1 0.0206
6142 Solute carrier family 22 member 8 SLC22A8 0.0204
146 Androgen receptor AR 0.0203
320 5-hydroxytryptamine 1A receptor HTR1A 0.0202
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.02
477 DNA topoisomerase 4 subunit A parC 0.0198
886 DNA topoisomerase 4 subunit A parC 0.0198
6226 DNA topoisomerase 4 subunit A parC 0.0198
404 DNA gyrase subunit A gyrA 0.0195
6224 DNA gyrase subunit A gyrA 0.0195
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0194
632 Alpha-1B adrenergic receptor ADRA1B 0.0192
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0192
885 5-hydroxytryptamine 1B receptor HTR1B 0.0184
590 5-hydroxytryptamine 2C receptor HTR2C 0.0182
3923 Cholinesterase BCHE 0.0182
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0173
6147 Solute carrier family 22 member 3 SLC22A3 0.0171
777 Tumor necrosis factor TNF 0.0171
3941 Amine oxidase [flavin-containing] A MAOA 0.0167
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0166
847 Mu-type opioid receptor OPRM1 0.0164
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0162
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0161
51 Muscarinic acetylcholine receptor M3 CHRM3 0.016
789 Alpha-1D adrenergic receptor ADRA1D 0.016
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0159
725 5-hydroxytryptamine 1D receptor HTR1D 0.0159
731 HIV-1 protease HIV-1 protease 0.0158
465 Calmodulin CALM1 0.0156
341 5-hydroxytryptamine 3 receptor HTR3A 0.0156
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0155
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0154
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0152
629 Alpha-2B adrenergic receptor ADRA2B 0.0152
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.015
6143 Solute carrier family 22 member 7 SLC22A7 0.0149
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0146
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
467 Delta-type opioid receptor OPRD1 0.0143
2449 Tubulin alpha-3 chain TUBA1A 0.0142
260 Cytochrome P450 51 ERG11 0.0142
761 Cytochrome P450 51 ERG11 0.0142
3163 Cytochrome P450 51 cyp51 0.0142
6014 Cytochrome P450 2A13 CYP2A13 0.0142
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.014
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0139
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0138
638 D(3) dopamine receptor DRD3 0.0137
833 Organic cation/carnitine transporter 1 SLC22A4 0.0137
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0137
6228 Nuclear receptor coactivator 1 NCOA1 0.0135
2164 Multidrug resistance-associated protein 4 ABCC4 0.0134
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0134
6141 Sodium/bile acid cotransporter SLC10A1 0.0133
378 Alpha-2C adrenergic receptor ADRA2C 0.0128
696 Kappa-type opioid receptor OPRK1 0.0127
6148 Multidrug resistance-associated protein 7 ABCC10 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0126
613 Atrial natriuretic peptide receptor A NPR1 0.0122
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
713 Sodium-dependent dopamine transporter SLC6A3 0.0121
844 Epidermal growth factor receptor EGFR 0.012
373 Transthyretin TTR 0.0119
3939 Amine oxidase [flavin-containing] B MAOB 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0118
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0118
48 Pyridoxal kinase PDXK 0.0116
1517 Beta-3 adrenergic receptor ADRB3 0.0116
818 50S ribosomal protein L10 rplJ 0.0115
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0115
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0114
6182 Cytochrome P450 2J2 CYP2J2 0.0113
122 P2Y purinoceptor 12 P2RY12 0.0109
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0108
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0107
16 Adenosine A1 receptor ADORA1 0.0107
1192 Sulfotransferase 1A1 SULT1A1 0.0106
2107 Microtubule-associated protein 1A MAP1A 0.0106
4604 Liver carboxylesterase 1 CES1 0.0104
3947 Xanthine dehydrogenase/oxidase XDH 0.0104
1178 Adenosine A2a receptor ADORA2A 0.0102
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0102
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0101
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0101
1024 Solute carrier family 22 member 11 SLC22A11 0.01
6020 Aldehyde oxidase AOX1 0.01
6220 Aryl hydrocarbon receptor AHR 0.0099
571 Melatonin receptor type 1A MTNR1A 0.0098
362 Melatonin receptor type 1B MTNR1B 0.0098
1852 Microtubule-associated protein 2 MAP2 0.0097
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0097
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
436 5-hydroxytryptamine 2B receptor HTR2B 0.0095
381 Prolactin receptor PRLR 0.0093
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0093
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0093
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.009
1757 Myeloperoxidase MPO 0.009
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0089
474 Acetylcholinesterase ACHE 0.0089
504 Mast/stem cell growth factor receptor KIT 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
380 Cytochrome P450 17A1 CYP17A1 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0087
432 D(4) dopamine receptor DRD4 0.0087
6031 Cytochrome P450 3A43 CYP3A43 0.0086
6137 Multidrug resistance-associated protein 6 ABCC6 0.0086
790 DNA polymerase subunit alpha B POLA2 0.0084
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
124 Histamine H2 receptor HRH2 0.0081
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0081
4120 NADPH--cytochrome P450 reductase POR 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0077
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0076
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0076
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0076
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0075
1010 Cytochrome P450 51A1 CYP51A1 0.0075
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0075
3932 Glutathione S-transferase A2 GSTA2 0.0075
716 5-hydroxytryptamine 7 receptor HTR7 0.0075
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0075
737 Mineralocorticoid receptor NR3C2 0.0074
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
228 Beta platelet-derived growth factor receptor PDGFRB 0.0074
4228 Keratin, type II cytoskeletal 7 KRT7 0.0074
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0072
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0072
992 Protein tyrosine kinase 2 beta PTK2B 0.007
68 Cannabinoid receptor 1 CNR1 0.007
26 Vascular endothelial growth factor receptor 3 FLT4 0.0069
6043 Putative G-protein coupled receptor 44 GPR44 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
407 Vascular endothelial growth factor receptor 2 KDR 0.0068
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0067
32 Vascular endothelial growth factor receptor 1 FLT1 0.0066
70 Type-1 angiotensin II receptor AGTR1 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
6136 Multidrug resistance-associated protein 5 ABCC5 0.0065
33 Cystine/glutamate transporter SLC7A11 0.0064
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
4122 Histone deacetylase 2 HDAC2 0.0062
814 Ryanodine receptor 1 RYR1 0.0062
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0062
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0062
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.006
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.006
1629 Transcription factor AP-1 JUN 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0059
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0059
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
1656 CYP2B protein CYP2B 0.0058
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0058
163 D(1B) dopamine receptor DRD5 0.0056
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0056
511 5-hydroxytryptamine 1F receptor HTR1F 0.0056
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
4203 Histamine N-methyltransferase HNMT 0.0054
273 Apoptosis regulator Bcl-2 BCL2 0.0054
1649 Small inducible cytokine A2 CCL2 0.0054
5998 Toll-like receptor 8 TLR8 0.0053
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0053
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
811 Translocator protein TSPO 0.0052
3830 Calreticulin CALR 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0052
3810 Catechol O-methyltransferase COMT 0.0052
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0051
4103 Proteasome subunit beta type 2 PSMB2 0.0051
4102 Proteasome subunit beta type 5 PSMB5 0.0051
4101 Proteasome subunit beta type 1 PSMB1 0.0051
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0051
284 DNA-directed RNA polymerase beta chain rpoB 0.0051
5773 DNA-directed RNA polymerase beta chain rpoB 0.0051
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0051
3809 Estrogen-related receptor gamma ESRRG 0.005
4210 Toll-like receptor 4 TLR4 0.005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.005
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.005
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.005
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.005
4311 tRNA TRDMT1 0.005
4325 tRNA trmD 0.005
4328 tRNA trmD 0.005
295 Carbonic anhydrase 1 CA1 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
904 Glutathione S-transferase P GSTP1 0.0049
6035 Nuclear receptor ROR-beta RORB 0.0049
856 Vitamin D3 receptor VDR 0.0049
6034 Hydroxyindole O-methyltransferase ASMT 0.0049
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0049
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0049
6036 Eosinophil peroxidase EPX 0.0049
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0048
239 Coagulation factor X F10 0.0048
2112 Toll-like receptor 9 TLR9 0.0048
1291 cAMP response element-binding protein CREB1 0.0048
6102 Arylamine N-acetyltransferase 2 NAT2 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
226 Gonadotropin-releasing hormone receptor GNRHR 0.0047
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
6085 Fatty acid-binding protein, intestinal FABP2 0.0046
1256 5-hydroxytryptamine 6 receptor HTR6 0.0046
173 Toll-like receptor 7 TLR7 0.0046
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0045
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0045
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
823 Fibroblast growth factor receptor 2 FGFR2 0.0044
3957 Adenosine deaminase ADA 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
106 Cannabinoid receptor 2 CNR2 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
765 Indoleamine 2,3-dioxygenase IDO1 0.0042
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0042
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
427 Substance-P receptor TACR1 0.0041
275 Arachidonate 5-lipoxygenase ALOX5 0.0041
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6167 Organic solute transporter subunit beta OSTB 0.004
6166 Organic solute transporter subunit alpha OSTA 0.004
592 Carbonic anhydrase 4 CA4 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
780 Retinoic acid receptor RXR-gamma RXRG 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4192 DNA topoisomerase 2-beta TOP2B 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
528 5-hydroxytryptamine 1E receptor HTR1E 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
1050 Bile salt sulfotransferase SULT2A1 0.0038
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0038
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0037
6149 Solute carrier family 22 member 10 SLC22A10 0.0037
2539 Tubulin alpha-1 chain TUBA4A 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0037
88 Retinoic acid receptor RXR-beta RXRB 0.0036
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0036
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0036
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0035
976 Platelet glycoprotein IX GP9 0.0035
482 Glycine receptor subunit alpha-1 GLRA1 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
6432 Transporter snf 0.0035
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0035
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0035
1374 Natriuretic peptides B NPPB 0.0035
1827 Gap junction alpha-1 protein GJA1 0.0035
1908 Vascular cell adhesion protein 1 VCAM1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0034
1063 Signal transducer and activator of transcription 5B STAT5B 0.0034
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
94 5-hydroxytryptamine 4 receptor HTR4 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
921 Glutamate receptor 2 GRIA2 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0033
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0033
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0032
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
908 Glutathione S-transferase theta-1 GSTT1 0.0032
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
84 Nuclear receptor 0B1 NR0B1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0031
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0031
705 Glutamate receptor 1 GRIA1 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
357 Carbonic anhydrase 2 CA2 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.003
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0029
319 Opioid receptor, sigma 1 OPRS1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
54 Prothrombin F2 0.0028
165 FL cytokine receptor FLT3 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
634 Squalene monooxygenase SQLE 0.0027
7196 Squalene monooxygenase ERG1 0.0027
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
469 Annexin A1 ANXA1 0.0027
569 Retinal dehydrogenase 2 ALDH1A2 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
1648 Elastin ELN 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
6859 Protein S100-A4 S100A4 0.0025
1618 High affinity nerve growth factor receptor NTRK1 0.0025
251 Alcohol dehydrogenase 1A ADH1A 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
611 Retinal dehydrogenase 1 ALDH1A1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0025
1275 Estrogen sulfotransferase SULT1E1 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
751 Potassium channel subfamily K member 6 KCNK6 0.0023
822 Aldose reductase AKR1B1 0.0023
6126 Carbonic anhydrase 7 CA7 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
1992 Vitamin D-binding protein GC 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
6163 Copper-transporting ATPase 2 ATP7B 0.0022
6165 Copper-transporting ATPase 1 ATP7A 0.0022
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0022
4773 Deoxycytidine kinase DCK 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.0021
2091 Endoplasmin HSP90B1 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
172 Potassium channel subfamily K member 1 KCNK1 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
6122 Carbonic anhydrase 3 CA3 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
7 Nitric oxide synthase, inducible NOS2 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
5787 Angiopoietin-1 receptor TEK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
164 Histamine H4 receptor HRH4 0.0019
518 Peroxidase/catalase T katG 0.0018
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
770 Retinoic acid-induced protein 3 GPRC5A 0.0018
719 Retinoic acid receptor responder protein 1 RARRES1 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
229 Retinoic acid receptor beta RARB 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
563 Thyroid peroxidase TPO 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
798 Osteocalcin BGLAP 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
1243 Cathepsin D CTSD 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0016
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
3233 Bile acid receptor NR1H4 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1541 Metalloproteinase mmp20 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0012
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
345 Plasma retinol-binding protein RBP4 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
572 Integrin alpha-L ITGAL 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
6218 Pannexin-1 PANX1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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