DT-Web: DB00540

Identification

Name

Nortriptyline

Accession Number

DB00540 (APRD00602)

Type

small molecule

Description

Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

263.3767

Groups

approved

Monoisotopic Weight

263.167399677

Pharmacology

Indication

For the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.

Mechanism of action

It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.

Absorption

Well absorbed from the GI tract. Peak plasma concentrations occur 7-8.5 hours following oral administration.

Protein binding

Highly protein-bound in plasma and tissues.

Biotransformation

Undergoes hepatic metabolism via the same pathway as other TCAs.

Route of elimination

Approximately one-third of a single orally administered dose is excreted in urine within 24 hours. Small amounts are excreted in feces via biliary elimination.

Toxicity

Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if atazanavir if initiated, discontinued or dose changed.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like nortriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as nortriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Carbamazepine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, nortriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if carbamazepine is initiated, discontinued or dose changed.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, nortriptyline, decreases the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, nortriptyline.
Dobutamine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dopamine.
Duloxetine	Possible increase in the levels of this agent when used with duloxetine
Ephedra	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of ephedrine.
Epinephrine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of epinephrine.
Fenoterol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of fenoterol.
Fluconazole	Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of nortriptyline if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of nortriptyline if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of nortriptyline if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, nortriptyline, decreases the effect of guanethidine.
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of isoproterenol.
Ketoconazole	Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of nortriptyline by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if ketoconazole is initiated, discontinued or dose changed.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephentermine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of mephentermine.
Metaraminol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of methoxamine.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of the tricyclic antidepressant, nortriptyline.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, nortriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, nortriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Nortriptyline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terbinafine	Terbinafine may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if terbinafine is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide	Trimethobenzamide and Nortriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Nortriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Nortriptyline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vilazodone	Monitor for toxic effects of tricyclic antidepressants if a selective serotonin reuptake inhibitor (SSRI) is initiated or the dose is increased. The influence of the SSRI may take several days or weeks to be fully realized or resolved.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and nortriptyline, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Avoid excessive quantities of coffee or tea (Caffeine).
Take with food to reduce irritation.
Avoid alcohol.

Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Roubert C, Cox PJ, Bruss M, Hamon M, Bonisch H, Giros B: Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. J Biol Chem. 2001 Mar 16;276(11):8254-60. Epub 2000 Nov 22. - Pubmed Roubert C, Sagne C, Kapsimali M, Vernier P, Bourrat F, Giros B: A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Mol Pharmacol. 2001 Sep;60(3):462-73. - Pubmed Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, Kim DK: Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression. JAMA. 2006 Oct 4;296(13):1609-18. - Pubmed Barker EL, Blakely RD: Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Mol Pharmacol. 1996 Oct;50(4):957-65. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.6536
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Joyce PR, Mulder RT, Luty SE, McKenzie JM, Miller AL, Rogers GR, Kennedy MA: Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. Int J Neuropsychopharmacol. 2003 Dec;6(4):339-46. - Pubmed Wisner KL, Hanusa BH, Perel JM, Peindl KS, Piontek CM, Sit DK, Findling RL, Moses-Kolko EL: Postpartum depression: a randomized trial of sertraline versus nortriptyline. J Clin Psychopharmacol. 2006 Aug;26(4):353-60. - Pubmed Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, Sweet RA, Davis S, Kirshner MA, Houck PR, Stack JA, Reynolds CF, Kupfer DJ: Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology. 2000 Nov;23(5):587-90. - Pubmed Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Rausch JL, Moeller FG, Johnson ME: Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome. J Clin Psychopharmacol. 2003 Apr;23(2):138-44. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.5199
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.512
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.3858
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Sadava D, Wilmington K: Tricyclic antidepressant drugs affect histamine receptors in human leukocytes. Life Sci. 1984 Dec 17;35(25):2545-8. - Pubmed
DTHybrid score	0.8232
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.67
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	no
Actions	antagonist
References	Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.3206
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	1.0493
Muscarinic acetylcholine receptor M2
Name	Muscarinic acetylcholine receptor M2
Gene Name	CHRM2
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.8859
Muscarinic acetylcholine receptor M3
Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.8897
Muscarinic acetylcholine receptor M4
Name	Muscarinic acetylcholine receptor M4
Gene Name	CHRM4
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6588
Muscarinic acetylcholine receptor M5
Name	Muscarinic acetylcholine receptor M5
Gene Name	CHRM5
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5618

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999 Jun;39(6):567-77. - Pubmed Olesen OV, Linnet K: Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997 Jun;25(6):740-4. - Pubmed
DTHybrid score	1.035
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999 Jun;39(6):567-77. - Pubmed
DTHybrid score	1.1499
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Olesen OV, Linnet K: Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997 Jun;25(6):740-4. - Pubmed
DTHybrid score	0.7107
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Olesen OV, Linnet K: Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997 Jun;25(6):740-4. - Pubmed
DTHybrid score	0.6648
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.7396
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed
DTHybrid score	0.4564
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5106
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4323

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.5501
4924	Cytochrome P450 2C8	CYP2C8	0.3944
632	Alpha-1B adrenergic receptor	ADRA1B	0.3548
831	D(2) dopamine receptor	DRD2	0.3432
6030	Cytochrome P450 2B6	CYP2B6	0.3224
318	Alpha-2A adrenergic receptor	ADRA2A	0.3095
6107	Cytochrome P450 3A7	CYP3A7	0.3043
590	5-hydroxytryptamine 2C receptor	HTR2C	0.2857
713	Sodium-dependent dopamine transporter	SLC6A3	0.28
23	D(1A) dopamine receptor	DRD1	0.2519
290	Prostaglandin G/H synthase 2	PTGS2	0.209
6024	Cytochrome P450 1A1	CYP1A1	0.1982
629	Alpha-2B adrenergic receptor	ADRA2B	0.1797
378	Alpha-2C adrenergic receptor	ADRA2C	0.1678
5718	Cytochrome P450 2A6	CYP2A6	0.1675
432	D(4) dopamine receptor	DRD4	0.1504
638	D(3) dopamine receptor	DRD3	0.1478
6145	Solute carrier family 22 member 1	SLC22A1	0.1452
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1394
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1321
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1275
766	Beta-2 adrenergic receptor	ADRB2	0.1259
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1242
3941	Amine oxidase [flavin-containing] A	MAOA	0.1242
3923	Cholinesterase	BCHE	0.1231
193	Beta-1 adrenergic receptor	ADRB1	0.1215
6144	Solute carrier family 22 member 2	SLC22A2	0.1124
716	5-hydroxytryptamine 7 receptor	HTR7	0.1087
6106	Cytochrome P450 2C18	CYP2C18	0.1069
1729	Solute carrier family 22 member 6	SLC22A6	0.1033
163	D(1B) dopamine receptor	DRD5	0.0947
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0924
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0908
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0891
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0861
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.085
131	Synaptic vesicular amine transporter	SLC18A2	0.0828
118	Organic cation/carnitine transporter 2	SLC22A5	0.0811
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0797
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0765
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0753
3939	Amine oxidase [flavin-containing] B	MAOB	0.0739
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0728
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.072
862	Multidrug resistance-associated protein 1	ABCC1	0.0696
833	Organic cation/carnitine transporter 1	SLC22A4	0.0653
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0639
465	Calmodulin	CALM1	0.0629
6147	Solute carrier family 22 member 3	SLC22A3	0.062
528	5-hydroxytryptamine 1E receptor	HTR1E	0.061
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0577
1898	Cytochrome P450 1B1	CYP1B1	0.0569
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0565
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0565
696	Kappa-type opioid receptor	OPRK1	0.0557
847	Mu-type opioid receptor	OPRM1	0.055
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.054
3811	Cytochrome P450 19A1	CYP19A1	0.0535
94	5-hydroxytryptamine 4 receptor	HTR4	0.0528
124	Histamine H2 receptor	HRH2	0.0514
467	Delta-type opioid receptor	OPRD1	0.0511
1656	CYP2B protein	CYP2B	0.0504
6142	Solute carrier family 22 member 8	SLC22A8	0.0496
2164	Multidrug resistance-associated protein 4	ABCC4	0.0472
1517	Beta-3 adrenergic receptor	ADRB3	0.0458
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0457
6432	Transporter	snf	0.0449
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0448
776	Bile salt export pump	ABCB11	0.0417
891	Dihydropteroate synthase	folP	0.0408
5359	Dihydropteroate synthase	folP	0.0408
7175	Dihydropteroate synthase	sulI	0.0408
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0407
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0406
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0397
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0385
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0385
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0382
6143	Solute carrier family 22 member 7	SLC22A7	0.0376
260	Cytochrome P450 51	ERG11	0.0368
761	Cytochrome P450 51	ERG11	0.0368
3163	Cytochrome P450 51	cyp51	0.0368
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0368
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0367
6182	Cytochrome P450 2J2	CYP2J2	0.0362
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0361
731	HIV-1 protease	HIV-1 protease	0.0359
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0354
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0353
474	Acetylcholinesterase	ACHE	0.0348
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0344
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0343
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0336
275	Arachidonate 5-lipoxygenase	ALOX5	0.0334
136	Estrogen receptor	ESR1	0.0331
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0331
1757	Myeloperoxidase	MPO	0.033
36	Insulin receptor	INSR	0.0325
1024	Solute carrier family 22 member 11	SLC22A11	0.0324
2129	Sucrase-isomaltase, intestinal	SI	0.0317
6031	Cytochrome P450 3A43	CYP3A43	0.0315
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.031
817	DNA topoisomerase 2-alpha	TOP2A	0.0298
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0298
871	Glucocorticoid receptor	NR3C1	0.0297
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0291
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0291
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0291
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0285
844	Epidermal growth factor receptor	EGFR	0.0282
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0273
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0268
1618	High affinity nerve growth factor receptor	NTRK1	0.0267
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0265
468	Cytochrome P450 4A11	CYP4A11	0.0257
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0253
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.025
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.025
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0248
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0245
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0235
174	Sigma 1-type opioid receptor	SIGMAR1	0.023
122	P2Y purinoceptor 12	P2RY12	0.0228
482	Glycine receptor subunit alpha-1	GLRA1	0.0227
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0226
70	Type-1 angiotensin II receptor	AGTR1	0.0225
828	Phenylalanine-4-hydroxylase	PAH	0.0224
3109	Phenylalanine-4-hydroxylase	phhA	0.0224
723	Cytosolic phospholipase A2	PLA2G4A	0.0224
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0221
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0216
811	Translocator protein	TSPO	0.0216
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0211
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0211
146	Androgen receptor	AR	0.0211
777	Tumor necrosis factor	TNF	0.0208
380	Cytochrome P450 17A1	CYP17A1	0.0208
6102	Arylamine N-acetyltransferase 2	NAT2	0.0205
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0205
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0204
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0204
373	Transthyretin	TTR	0.0203
705	Glutamate receptor 1	GRIA1	0.0202
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.02
183	Vascular endothelial growth factor A	VEGFA	0.0199
1341	Histamine H3 receptor	HRH3	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0196
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0195
6138	Multidrug resistance protein 3	ABCB4	0.0194
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0193
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0193
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0192
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0192
1636	Trace amine-associated receptor 1	TAAR1	0.0192
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0191
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0191
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0189
4604	Liver carboxylesterase 1	CES1	0.0186
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0184
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0183
6220	Aryl hydrocarbon receptor	AHR	0.0183
6148	Multidrug resistance-associated protein 7	ABCC10	0.0182
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0181
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.018
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0179
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0178
16	Adenosine A1 receptor	ADORA1	0.0175
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0173
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0171
477	DNA topoisomerase 4 subunit A	parC	0.017
886	DNA topoisomerase 4 subunit A	parC	0.017
6226	DNA topoisomerase 4 subunit A	parC	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
738	Monocarboxylate transporter 1	SLC16A1	0.0168
516	Neurotensin receptor type 2	NTSR2	0.0168
404	DNA gyrase subunit A	gyrA	0.0167
6224	DNA gyrase subunit A	gyrA	0.0167
756	Sex hormone-binding globulin	SHBG	0.0165
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0164
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0164
6141	Sodium/bile acid cotransporter	SLC10A1	0.0162
614	Progesterone receptor	PGR	0.0162
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.016
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.016
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.016
164	Histamine H4 receptor	HRH4	0.0155
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0155
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0155
504	Mast/stem cell growth factor receptor	KIT	0.0155
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0154
1275	Estrogen sulfotransferase	SULT1E1	0.0154
6014	Cytochrome P450 2A13	CYP2A13	0.0154
3947	Xanthine dehydrogenase/oxidase	XDH	0.0152
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0149
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0149
1178	Adenosine A2a receptor	ADORA2A	0.0148
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0147
6137	Multidrug resistance-associated protein 6	ABCC6	0.0146
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0145
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0144
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0144
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0144
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0142
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0142
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0142
921	Glutamate receptor 2	GRIA2	0.0142
904	Glutathione S-transferase P	GSTP1	0.014
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.014
232	Corticosteroid-binding globulin	SERPINA6	0.0139
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0138
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0137
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0137
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0137
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0135
6085	Fatty acid-binding protein, intestinal	FABP2	0.0134
1050	Bile salt sulfotransferase	SULT2A1	0.0133
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0132
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0132
1010	Cytochrome P450 51A1	CYP51A1	0.013
6136	Multidrug resistance-associated protein 5	ABCC5	0.013
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0128
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0127
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0127
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0127
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0124
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0123
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0123
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0122
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0122
427	Substance-P receptor	TACR1	0.012
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.012
407	Vascular endothelial growth factor receptor 2	KDR	0.0119
818	50S ribosomal protein L10	rplJ	0.0118
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0118
3426	Glutamine synthetase	glnA	0.0117
3987	Glutamine synthetase	GLUL	0.0117
592	Carbonic anhydrase 4	CA4	0.0116
1507	Cytochrome c	CYCS	0.0115
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0115
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0115
768	FK506-binding protein 1A	FKBP1A	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0112
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0111
4122	Histone deacetylase 2	HDAC2	0.0111
869	Estrogen receptor beta	ESR2	0.011
4148	Serine/threonine-protein kinase mTOR	MTOR	0.011
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.011
26	Vascular endothelial growth factor receptor 3	FLT4	0.011
161	Tubulin beta chain	TUBB	0.011
312	Tubulin beta chain	TUB2	0.011
295	Carbonic anhydrase 1	CA1	0.011
4120	NADPH--cytochrome P450 reductase	POR	0.0107
558	Solute carrier family 12 member 1	SLC12A1	0.0107
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0107
6043	Putative G-protein coupled receptor 44	GPR44	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
32	Vascular endothelial growth factor receptor 1	FLT1	0.0105
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0104
823	Fibroblast growth factor receptor 2	FGFR2	0.0104
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0104
3312	Fatty acid-binding protein, brain	FABP7	0.0104
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0101
365	Dihydrofolate reductase	DHFR	0.0101
2381	Dihydrofolate reductase	DFR1	0.0101
2833	Dihydrofolate reductase	Not Available	0.0101
2931	Dihydrofolate reductase	folA	0.0101
3544	Dihydrofolate reductase	folA	0.0101
3682	Dihydrofolate reductase	folA	0.0101
6642	Dihydrofolate reductase	folA	0.0101
6756	Dihydrofolate reductase	dfrA	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
737	Mineralocorticoid receptor	NR3C2	0.01
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0099
2211	Fatty acid-binding protein, heart	FABP3	0.0098
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0098
5787	Angiopoietin-1 receptor	TEK	0.0097
357	Carbonic anhydrase 2	CA2	0.0096
49	Endothelin B receptor	EDNRB	0.0096
153	Dopamine beta-hydroxylase	DBH	0.0095
566	Serotransferrin	TF	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
29	Tubulin beta-1 chain	TUBB1	0.0094
3810	Catechol O-methyltransferase	COMT	0.0094
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0092
578	Endothelin-1 receptor	EDNRA	0.009
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.009
3932	Glutathione S-transferase A2	GSTA2	0.009
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0089
459	Retinoic acid receptor RXR-alpha	RXRA	0.0089
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0088
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0088
952	Dipeptidyl peptidase 4	DPP4	0.0087
4203	Histamine N-methyltransferase	HNMT	0.0086
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0085
6020	Aldehyde oxidase	AOX1	0.0085
273	Apoptosis regulator Bcl-2	BCL2	0.0084
6126	Carbonic anhydrase 7	CA7	0.0084
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0084
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
319	Opioid receptor, sigma 1	OPRS1	0.0082
185	Vasopressin V1a receptor	AVPR1A	0.0082
68	Cannabinoid receptor 1	CNR1	0.0081
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.008
565	Extracellular calcium-sensing receptor	CASR	0.008
33	Cystine/glutamate transporter	SLC7A11	0.008
233	Potassium channel subfamily K member 2	KCNK2	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0079
6151	Monocarboxylate transporter 10	SLC16A10	0.0079
173	Toll-like receptor 7	TLR7	0.0079
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
518	Peroxidase/catalase T	katG	0.0077
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0077
1629	Transcription factor AP-1	JUN	0.0077
7	Nitric oxide synthase, inducible	NOS2	0.0076
634	Squalene monooxygenase	SQLE	0.0076
7196	Squalene monooxygenase	ERG1	0.0076
1648	Elastin	ELN	0.0076
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0076
1864	RET proto-oncogene	RET	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0075
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0075
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0075
814	Ryanodine receptor 1	RYR1	0.0074
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0074
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0073
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
1374	Natriuretic peptides B	NPPB	0.0072
1827	Gap junction alpha-1 protein	GJA1	0.0072
1908	Vascular cell adhesion protein 1	VCAM1	0.0072
1192	Sulfotransferase 1A1	SULT1A1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
54	Prothrombin	F2	0.007
3601	Dihydropteroate synthase 1	folP1	0.007
3807	Dihydropteroate synthase 1	folP1	0.007
3808	Dihydropteroate synthase 2	folP2	0.007
6103	Arylamine N-acetyltransferase 1	NAT1	0.007
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.007
239	Coagulation factor X	F10	0.007
2112	Toll-like receptor 9	TLR9	0.0069
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0068
2539	Tubulin alpha-1 chain	TUBA4A	0.0068
563	Thyroid peroxidase	TPO	0.0068
284	DNA-directed RNA polymerase beta chain	rpoB	0.0067
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0067
4311	tRNA	TRDMT1	0.0067
4325	tRNA	trmD	0.0067
4328	tRNA	trmD	0.0067
780	Retinoic acid receptor RXR-gamma	RXRG	0.0066
251	Alcohol dehydrogenase 1A	ADH1A	0.0065
444	Alcohol dehydrogenase 1B	ADH1B	0.0065
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0064
6146	High affinity copper uptake protein 1	SLC31A1	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
6149	Solute carrier family 22 member 10	SLC22A10	0.0063
65	Matrix metalloproteinase-9	Not Available	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0062
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0062
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0062
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
88	Retinoic acid receptor RXR-beta	RXRB	0.006
4237	50S ribosomal protein L22	rplV	0.006
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0059
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0059
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0059
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0059
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0059
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0059
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0058
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0058
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0058
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0058
6044	Serum paraoxonase/lactonase 3	PON3	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
1483	Membrane copper amine oxidase	AOC3	0.0057
976	Platelet glycoprotein IX	GP9	0.0057
703	NADPH azoreductase	azr	0.0056
5300	Antigen peptide transporter 1	TAP1	0.0056
6506	Stathmin-4	STMN4	0.0055
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0055
106	Cannabinoid receptor 2	CNR2	0.0054
1714	Mitogen-activated protein kinase 3	MAPK3	0.0054
165	FL cytokine receptor	FLT3	0.0053
6033	High affinity interleukin-8 receptor A	CXCR1	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0053
3937	Fatty-acid amide hydrolase	FAAH	0.0053
856	Vitamin D3 receptor	VDR	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
3090	Chitosanase	csn	0.0052
1048	Protein S100-A13	S100A13	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
2226	Protein S100-A12	S100A12	0.0052
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
4192	DNA topoisomerase 2-beta	TOP2B	0.0051
908	Glutathione S-transferase theta-1	GSTT1	0.005
517	Alcohol dehydrogenase 1C	ADH1C	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6766	O-GlcNAcase BT_4395	BT_4395	0.0049
4103	Proteasome subunit beta type 2	PSMB2	0.0049
4102	Proteasome subunit beta type 5	PSMB5	0.0049
4101	Proteasome subunit beta type 1	PSMB1	0.0049
2230	Catalase	CAT	0.0049
3249	Catalase	katA	0.0049
3625	Catalase	katA	0.0049
4539	Catalase	katA	0.0049
4941	Catalase	katB	0.0049
24	Thymidylate synthase	TMP1	0.0049
359	Thymidylate synthase	TYMS	0.0049
2626	Thymidylate synthase	thyA	0.0049
2729	Thymidylate synthase	thyA	0.0049
5352	Thymidylate synthase	THYA	0.0049
3404	Exotoxin A	eta	0.0049
2132	Protein S100-B	S100B	0.0049
6859	Protein S100-A4	S100A4	0.0048
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0048
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0048
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0048
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0047
5934	Cytochrome P450 26A1	CYP26A1	0.0047
1992	Vitamin D-binding protein	GC	0.0047
2207	Rhodopsin	RHO	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
1253	Interferon gamma	IFNG	0.0046
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
3086	Plasmepsin-2	Not Available	0.0046
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0046
6174	50S ribosomal protein L32	rpmF	0.0046
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0046
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
751	Potassium channel subfamily K member 6	KCNK6	0.0045
1196	Complement decay-accelerating factor	CD55	0.0045
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
4238	50S ribosomal protein L4	rplD	0.0045
5578	50S ribosomal protein L4	rplD	0.0045
6173	50S ribosomal protein L4	rplD	0.0045
6219	50S ribosomal protein L4	rplD	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
84	Nuclear receptor 0B1	NR0B1	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0043
469	Annexin A1	ANXA1	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0042
1525	Heparin-binding growth factor 2	FGF2	0.0042
6131	Carbonic anhydrase 14	CA14	0.0041
172	Potassium channel subfamily K member 1	KCNK1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3913	Glutamic acid decarboxylase	GAD65	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
3957	Adenosine deaminase	ADA	0.004
581	Cytochrome P450 2R1	CYP2R1	0.0039
1541	Metalloproteinase	mmp20	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
3809	Estrogen-related receptor gamma	ESRRG	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2808	Chloramphenicol acetyltransferase 3	cat3	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0038
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0038
85	Growth hormone receptor	GHR	0.0038
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0037
1852	Microtubule-associated protein 2	MAP2	0.0037
489	Monocarboxylate transporter 2	SLC16A7	0.0037
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0036
1630	Integrin beta-2	ITGB2	0.0036
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0036
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0036
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
2417	Chloramphenicol acetyltransferase	cat	0.0036
3278	Chloramphenicol acetyltransferase	cat	0.0036
3856	Fibroblast growth factor receptor 3	FGFR3	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
162	Retinoic acid receptor gamma-1	RARG	0.0035
822	Aldose reductase	AKR1B1	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
4773	Deoxycytidine kinase	DCK	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
1039	Histone deacetylase 9	HDAC9	0.0035
2021	Thrombomodulin	THBD	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
3904	Alanine aminotransferase 2	GPT2	0.0034
735	Alanine aminotransferase 1	GPT	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
3639	Thymidine phosphorylase	deoA	0.0032
3936	Thymidine phosphorylase	TYMP	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0032
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0032
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0032
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0032
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0032
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
268	Adenosine A2b receptor	ADORA2B	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2298	Cytochrome P450-cam	camC	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
4217	Telomerase reverse transcriptase	TERT	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.003
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.003
5924	Microtubule-associated protein 4	MAP4	0.003
5923	Microtubule-associated protein tau	MAPT	0.003
1268	Neuropeptide S receptor	NPSR1	0.003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.003
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
936	Ephrin type-A receptor 2	EPHA2	0.0029
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0029
244	Angiotensin-converting enzyme	ACE	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0027
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
572	Integrin alpha-L	ITGAL	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6073	Potassium channel subfamily K member 9	KCNK9	0.0027
6072	Potassium channel subfamily K member 3	KCNK3	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
229	Retinoic acid receptor beta	RARB	0.0026
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0026
4226	Uridine phosphorylase 2	UPP2	0.0026
6042	Prostaglandin reductase 2	PTGR2	0.0026
730	Retinoic acid receptor alpha	RARA	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
3830	Calreticulin	CALR	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0025
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0024
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
1792	Tissue-type plasminogen activator	PLAT	0.0024
2320	Thymidine kinase, cytosolic	TK1	0.0024
4225	Uridine phosphorylase 1	UPP1	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0023
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0023
896	Glutathione S-transferase Mu 1	GSTM1	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
293	Gamma-glutamyl hydrolase	GGH	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
413	Amidophosphoribosyltransferase	PPAT	0.0022
2515	Amidophosphoribosyltransferase	purF	0.0022
3714	Amidophosphoribosyltransferase	purF	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
267	Plasminogen activator inhibitor 1	SERPINE1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0021
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6218	Pannexin-1	PANX1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0021
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0021
1053	BC269730_2	FADS1	0.0021
6459	Glycodelin	PAEP	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.002
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.002
1820	Beta-nerve growth factor	NGF	0.002
1313	Lactoylglutathione lyase	GLO1	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6221	Steroid hormone receptor ERR1	ESRRA	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
1243	Cathepsin D	CTSD	0.0019
6163	Copper-transporting ATPase 2	ATP7B	0.0019
6165	Copper-transporting ATPase 1	ATP7A	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
3221	Cytochrome c4	cc4	0.0019
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
719	Retinoic acid receptor responder protein 1	RARRES1	0.0018
770	Retinoic acid-induced protein 3	GPRC5A	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
569	Retinal dehydrogenase 2	ALDH1A2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
611	Retinal dehydrogenase 1	ALDH1A1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0015
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
798	Osteocalcin	BGLAP	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
283	SEC14-like protein 2	SEC14L2	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
4948	Cytochrome c-553	Not Available	0.0013
4923	Cytochrome c3	DvMF_2499	0.0013
4945	Cytochrome c3	Not Available	0.0013
4949	Cytochrome c3	DVU_3171	0.0013
4968	Cytochrome c3	cytc3	0.0013
4997	Cytochrome c3	SO_2727	0.0013
5219	Cytochrome c3	cyd	0.0013
4902	Nine-heme cytochrome c	Ddes_2038	0.0013
3189	High-molecular-weight cytochrome c	hmcA	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
4692	A/G-specific adenine glycosylase	mutY	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6228	Nuclear receptor coactivator 1	NCOA1	0.001
76	Nitric-oxide synthase, brain	NOS1	0.001
2802	Endoglucanase G	celCCG	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
4943	Cytochrome c6	petJ	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4916	Cyanoglobin	glbN	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4984	Neuroglobin	NGB	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
5000	HemO	hemO	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4961	Hemophore HasA	hasA	0.0009
4909	CooA protein	cooA	0.0009
4910	Cytoglobin	CYGB	0.0009
4935	Cytochrome c-554	cycA1	0.0009
644	Heme oxygenase 2	HMOX2	0.0009
4982	Heme oxygenase 2	pbsA2	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4972	P450cin	cinA	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4952	Catalase/peroxidase	katA	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
3093	Catalase HPII	katE	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
4920	Peroxidase/catalase	katG	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2119	Cytochrome b5	CYB5A	0.0007
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0007
4990	PpcA	ppcA	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
4988	Sulfite oxidase, mitochondrial	SUOX	0.0007
3570	Cytochrome P450 152A1	cypC	0.0007
3375	Acidic cytochrome c3	Not Available	0.0007
4289	Cytochrome P450	TT_P0059	0.0007
6262	Cytochrome P450	staP	0.0007
2915	Sensor protein fixL	fixL	0.0007
4944	Sensor protein fixL	fixL	0.0007
4992	Cytochrome c peroxidase	Not Available	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4385	Cytochrome c'	Not Available	0.0007
4967	Cytochrome c'	cycA	0.0007
5038	Cytochrome c'	Not Available	0.0007
5223	Cytochrome c'	cycP	0.0007
4813	Heme oxygenase	hmuO	0.0007
5769	Heme oxygenase	Not Available	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3291	Cytochrome c-552	cycA	0.0006
4927	Cytochrome c-552	nrfA	0.0006
4938	Cytochrome c-552	cycA	0.0006
4953	Cytochrome c-552	nrfA	0.0006
5217	Cytochrome c-552	cycM	0.0006
3102	Flavohemoprotein	hmp	0.0006
4969	Flavohemoprotein	hmp	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
693	Hemoglobin subunit beta	HBB	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00540 - Nortriptyline

Targets

Enzymes

Carriers

Predictions