DT-Web

DB00365 - Grepafloxacin


Identification
Name Grepafloxacin
Accession Number DB00365 (APRD01003)
Type small molecule
Description Grepafloxacin hydrochloride (Raxar®, Glaxo Wellcome) is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Grepafloxacin was withdrawn in the United States due to its side effect of lengthening the QT interval on the electrocardiogram, leading to cardiac events and sudden death. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 359.3947
Groups approved
Monoisotopic Weight 359.16451979
Pharmacology
Indication For treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
Mechanism of action Grepafloxacin exerts its antibacterial activity by inhibiting bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, essential enzymes for duplication, transcription, and repair of bacterial DNA.
Absorption Rapidly and extensively absorbed following oral administration. The absolute bioavailability is approximately 70%.
Protein binding 50%
Biotransformation Primarily hepatic via CYP1A2 and CYP3A4. The major metabolite is a glucuronide conjugate; minor metabolites include sulfate conjugates and oxidative metabolites. The oxidative metabolites are formed mainly by the cytochrome P450 enzyme CYP1A2, while the cytochrome P450 enzyme CYP3A4 plays a minor role. The nonconjugated metabolites have little antimicrobial activity compared with the parent drug, and the conjugated metabolites have no antimicrobial activity
Route of elimination Not Available
Toxicity Withdrawn from the US market in 1999 due to associations with QTc prolongation and adverse cardiovascular events.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Aluminium Formation of non-absorbable complexes
Aminophylline Grepafloxacin may increase the effect of aminophylline.
Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amitriptyline Increased risk of cardiotoxicity and arrhythmias
Amoxapine Increased risk of cardiotoxicity and arrhythmias
Astemizole Increased risk of cardiotoxicity and arrhythmias
Bepridil Increased risk of cardiotoxicity and arrhythmias
Bretylium Increased risk of cardiotoxicity and arrhythmias
Caffeine Grepafloxacin may increase the effect and toxicity of caffeine.
Calcium Calcium may decrease the absorption of grepafloxacin. Doses should be spaced apart by at least 2 hours.
Chlorpromazine Increased risk of cardiotoxicity and arrhythmias
Clomipramine Increased risk of cardiotoxicity and arrhythmias
Desipramine Increased risk of cardiotoxicity and arrhythmias
Dihydroquinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Doxepin Increased risk of cardiotoxicity and arrhythmias
Dyphylline Grepafloxacin may increase the effect of dyphylline.
Eltrombopag Affects hepatic enzyme CYP1A2 metabolism and may increase the level of eltrombopag.
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Fluphenazine Increased risk of cardiotoxicity and arrhythmias
Imipramine Increased risk of cardiotoxicity and arrhythmias
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Josamycin Increased risk of cardiotoxicity and arrhythmias
Magnesium Magnesium may decrease the absorption of grepafloxacin. Doses should be spaced apart by at least 2 hours.
Magnesium oxide Formation of non-absorbable complexes
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methotrimeprazine Increased risk of cardiotoxicity and arrhythmias
Nortriptyline Increased risk of cardiotoxicity and arrhythmias
Oxtriphylline Grepafloxacin may increase the effect of oxtriphylline.
Perphenazine Increased risk of cardiotoxicity and arrhythmias
Prochlorperazine Increased risk of cardiotoxicity and arrhythmias
Promazine Increased risk of cardiotoxicity and arrhythmias
Promethazine Increased risk of cardiotoxicity and arrhythmias
Propiomazine Increased risk of cardiotoxicity and arrhythmias
Protriptyline Increased risk of cardiotoxicity and arrhythmias
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Quinupristin This combination presents an increased risk of toxicity
Sotalol Increased risk of cardiotoxicity and arrhythmias
Sucralfate Formation of non-absorbable complexes
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Grepafloxacin may increase the effect of theophylline.
Thiethylperazine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Trifluoperazine Increased risk of cardiotoxicity and arrhythmias
Triflupromazine Increased risk of cardiotoxicity and arrhythmias
Trimipramine Increased risk of cardiotoxicity and arrhythmias
Zinc Formation of non-absorbable complexes
Food Interactions
  • Take without regard to meals.
  • Drink liberally but avoid coffee.

Targets


DNA gyrase subunit A
Name DNA gyrase subunit A
Gene Name gyrA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Stewart BA, Johnson AP, Woodford N: Relationship between mutations in parC and gyrA of clinical isolates of Streptococcus pneumoniae and resistance to ciprofloxacin and grepafloxacin. J Med Microbiol. 1999 Dec;48(12):1103-6. - Pubmed
  • Jorgensen JH, Weigel LM, Ferraro MJ, Swenson JM, Tenover FC: Activities of newer fluoroquinolones against Streptococcus pneumoniae clinical isolates including those with mutations in the gyrA, parC, and parE loci. Antimicrob Agents Chemother. 1999 Feb;43(2):329-34. - Pubmed
  • Griggs DJ, Marona H, Piddock LJ: Selection of moxifloxacin-resistant Staphylococcus aureus compared with five other fluoroquinolones. J Antimicrob Chemother. 2003 Jun;51(6):1403-7. Epub 2003 Apr 25. - Pubmed
DTHybrid score 0.8594
DNA topoisomerase 4 subunit A
Name DNA topoisomerase 4 subunit A
Gene Name parC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ernst EJ, Klepser ME, Petzold CR, Doern GV: Evaluation of survival and pharmacodynamic relationships for five fluoroquinolones in a neutropenic murine model of pneumococcal lung infection. Pharmacotherapy. 2002 Apr;22(4):463-70. - Pubmed
  • Morris JE, Pan XS, Fisher LM: Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity. Antimicrob Agents Chemother. 2002 Feb;46(2):582-5. - Pubmed
  • Kawamura-Sato K, Hasegawa T, Torii K, Ito H, Ohta M: Prevalence of Ile-460-Val/ParE substitution in clinical Streptococcus pneumoniae isolates that were less susceptible to fluoroquinolones. Curr Microbiol. 2005 Jul;51(1):27-30. Epub 2005 May 31. - Pubmed
DTHybrid score 0.8151

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Rodighiero V: Effects of liver disease on pharmacokinetics. An update. Clin Pharmacokinet. 1999 Nov;37(5):399-431. - Pubmed
  • Bril F, Gonzalez CD, Di Girolamo G: Antimicrobial agents-associated with QT interval prolongation. Curr Drug Saf. 2010 Jan;5(1):85-92. - Pubmed
DTHybrid score 0.4796
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Bernard E, Garraffo R, Leclercq-Boscherel B, Garret C, Bidault R, Dellamonica P. Drug Interaction between Grepafloxacin (GFX) and Rifampin (RIF) in Healthy Volunteers. Interscience Conference on Antimicrobial Agents and Chemotherapy. 1999 Sep;39(1). -
  • Pal D, Mitra AK: MDR- and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol. 2006 Sep;1(3):323-39. Epub 2006 Aug 2. - Pubmed
  • Owens RC Jr: QT prolongation with antimicrobial agents: understanding the significance. Drugs. 2004;64(10):1091-124. - Pubmed
DTHybrid score 0.5247

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Yamaguchi H, Yano I, Hashimoto Y, Inui KI: Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line caco-2. J Pharmacol Exp Ther. 2000 Oct;295(1):360-6. - Pubmed
  • Naruhashi K, Tamai I, Inoue N, Muraoka H, Sai Y, Suzuki N, Tsuji A: Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein. J Pharm Pharmacol. 2001 May;53(5):699-709. - Pubmed
  • Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. - Pubmed
DTHybrid score 0.4606
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate
References
  • Tamai I, Yamashita J, Kido Y, Ohnari A, Sai Y, Shima Y, Naruhashi K, Koizumi S, Tsuji A: Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J Pharmacol Exp Ther. 2000 Oct;295(1):146-52. - Pubmed
DTHybrid score 0.2534
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate
References
  • Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. - Pubmed
DTHybrid score 0.3807
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
DTHybrid score 0.2359
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.3364
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Sasabe H, Tsuji A, Sugiyama Y: Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther. 1998 Mar;284(3):1033-9. - Pubmed
DTHybrid score 0.3071

Predictions


Id Partner name Gene Name Score
6224 DNA gyrase subunit A gyrA 0.8594
886 DNA topoisomerase 4 subunit A parC 0.8151
6226 DNA topoisomerase 4 subunit A parC 0.8151
817 DNA topoisomerase 2-alpha TOP2A 0.426
4119 Cytochrome P450 2D6 CYP2D6 0.2269
4757 Cytochrome P450 2C9 CYP2C9 0.1996
4118 Cytochrome P450 3A5 CYP3A5 0.1945
6016 Cytochrome P450 2C19 CYP2C19 0.1751
6145 Solute carrier family 22 member 1 SLC22A1 0.1494
4924 Cytochrome P450 2C8 CYP2C8 0.1485
6107 Cytochrome P450 3A7 CYP3A7 0.146
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1388
6142 Solute carrier family 22 member 8 SLC22A8 0.1266
833 Organic cation/carnitine transporter 1 SLC22A4 0.1163
6024 Cytochrome P450 1A1 CYP1A1 0.111
6030 Cytochrome P450 2B6 CYP2B6 0.11
587 Serum albumin ALB 0.1047
6013 Cytochrome P450 2E1 CYP2E1 0.097
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0935
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0868
1024 Solute carrier family 22 member 11 SLC22A11 0.0822
6147 Solute carrier family 22 member 3 SLC22A3 0.0786
776 Bile salt export pump ABCB11 0.0771
5718 Cytochrome P450 2A6 CYP2A6 0.0747
6143 Solute carrier family 22 member 7 SLC22A7 0.071
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0681
20 Prostaglandin G/H synthase 1 PTGS1 0.0678
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0646
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0641
2164 Multidrug resistance-associated protein 4 ABCC4 0.0639
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0546
290 Prostaglandin G/H synthase 2 PTGS2 0.0518
492 Histamine H1 receptor HRH1 0.0498
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0475
6137 Multidrug resistance-associated protein 6 ABCC6 0.0461
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0436
1898 Cytochrome P450 1B1 CYP1B1 0.0431
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0427
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0406
556 Alpha-1A adrenergic receptor ADRA1A 0.039
6106 Cytochrome P450 2C18 CYP2C18 0.0382
193 Beta-1 adrenergic receptor ADRB1 0.0364
136 Estrogen receptor ESR1 0.0363
318 Alpha-2A adrenergic receptor ADRA2A 0.0357
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0356
766 Beta-2 adrenergic receptor ADRB2 0.0356
824 Sodium-dependent serotonin transporter SLC6A4 0.035
738 Monocarboxylate transporter 1 SLC16A1 0.0347
731 HIV-1 protease HIV-1 protease 0.0335
3811 Cytochrome P450 19A1 CYP19A1 0.033
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0325
831 D(2) dopamine receptor DRD2 0.0318
871 Glucocorticoid receptor NR3C1 0.0315
6141 Sodium/bile acid cotransporter SLC10A1 0.0315
3923 Cholinesterase BCHE 0.0311
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0298
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0289
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0288
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0288
502 5-hydroxytryptamine 2A receptor HTR2A 0.0287
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0286
633 Penicillin-binding proteins 1A/1B pbpA 0.0272
6136 Multidrug resistance-associated protein 5 ABCC5 0.0267
629 Alpha-2B adrenergic receptor ADRA2B 0.0266
36 Insulin receptor INSR 0.0258
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0258
632 Alpha-1B adrenergic receptor ADRA1B 0.0248
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0244
378 Alpha-2C adrenergic receptor ADRA2C 0.0239
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0239
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0238
789 Alpha-1D adrenergic receptor ADRA1D 0.0235
70 Type-1 angiotensin II receptor AGTR1 0.0234
3941 Amine oxidase [flavin-containing] A MAOA 0.0234
713 Sodium-dependent dopamine transporter SLC6A3 0.0228
23 D(1A) dopamine receptor DRD1 0.0228
614 Progesterone receptor PGR 0.0223
124 Histamine H2 receptor HRH2 0.022
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0218
723 Cytosolic phospholipase A2 PLA2G4A 0.0216
320 5-hydroxytryptamine 1A receptor HTR1A 0.0215
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0211
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0209
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0202
161 Tubulin beta chain TUBB 0.0202
312 Tubulin beta chain TUB2 0.0202
474 Acetylcholinesterase ACHE 0.0201
885 5-hydroxytryptamine 1B receptor HTR1B 0.0199
3939 Amine oxidase [flavin-containing] B MAOB 0.0197
341 5-hydroxytryptamine 3 receptor HTR3A 0.0194
1757 Myeloperoxidase MPO 0.0191
380 Cytochrome P450 17A1 CYP17A1 0.0189
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0186
4604 Liver carboxylesterase 1 CES1 0.0183
3947 Xanthine dehydrogenase/oxidase XDH 0.0182
645 Penicillin-binding protein 1A mrcA 0.018
5805 Penicillin-binding protein 1A ponA 0.018
6185 Penicillin-binding protein 1A mrcA 0.018
6799 Penicillin-binding protein 1A pbpA 0.018
590 5-hydroxytryptamine 2C receptor HTR2C 0.0176
6010 Thiamine transporter 1 SLC19A2 0.0175
592 Carbonic anhydrase 4 CA4 0.0173
357 Carbonic anhydrase 2 CA2 0.0173
725 5-hydroxytryptamine 1D receptor HTR1D 0.0169
5626 Nucleoside diphosphate kinase B NME2 0.0168
295 Carbonic anhydrase 1 CA1 0.0167
7 Nitric oxide synthase, inducible NOS2 0.0164
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0164
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0162
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0162
638 D(3) dopamine receptor DRD3 0.0162
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0161
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0159
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0158
175 Thiamin pyrophosphokinase 1 TPK1 0.0157
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0155
29 Tubulin beta-1 chain TUBB1 0.0155
13 Aminomethyltransferase, mitochondrial AMT 0.0154
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0153
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0152
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.015
468 Cytochrome P450 4A11 CYP4A11 0.015
131 Synaptic vesicular amine transporter SLC18A2 0.0147
737 Mineralocorticoid receptor NR3C2 0.0147
847 Mu-type opioid receptor OPRM1 0.0145
4773 Deoxycytidine kinase DCK 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
260 Cytochrome P450 51 ERG11 0.0144
761 Cytochrome P450 51 ERG11 0.0144
3163 Cytochrome P450 51 cyp51 0.0144
275 Arachidonate 5-lipoxygenase ALOX5 0.0144
465 Calmodulin CALM1 0.0143
273 Apoptosis regulator Bcl-2 BCL2 0.0142
6599 HTH-type transcriptional regulator ttgR ttgR 0.0142
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0139
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0139
844 Epidermal growth factor receptor EGFR 0.0138
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0137
5294 Nucleoside diphosphate kinase A NME1 0.0136
24 Thymidylate synthase TMP1 0.0135
359 Thymidylate synthase TYMS 0.0135
2626 Thymidylate synthase thyA 0.0135
2729 Thymidylate synthase thyA 0.0135
5352 Thymidylate synthase THYA 0.0135
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0135
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0133
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0133
908 Glutathione S-transferase theta-1 GSTT1 0.0133
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0133
2449 Tubulin alpha-3 chain TUBA1A 0.0132
373 Transthyretin TTR 0.0132
6149 Solute carrier family 22 member 10 SLC22A10 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
952 Dipeptidyl peptidase 4 DPP4 0.0131
1629 Transcription factor AP-1 JUN 0.0131
3307 Acriflavine resistance protein B acrB 0.013
4120 NADPH--cytochrome P450 reductase POR 0.013
904 Glutathione S-transferase P GSTP1 0.0129
338 DNA polymerase UL30 0.0128
379 DNA polymerase UL54 0.0128
697 DNA polymerase ORF28 0.0128
2482 DNA polymerase 43 0.0128
4104 DNA polymerase BALF5 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0125
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0125
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0124
467 Delta-type opioid receptor OPRD1 0.0124
432 D(4) dopamine receptor DRD4 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
869 Estrogen receptor beta ESR2 0.0122
777 Tumor necrosis factor TNF 0.0122
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0121
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0121
1 Peptidoglycan synthetase ftsI ftsI 0.0121
4155 Peptidoglycan synthetase ftsI ftsI 0.0121
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0119
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0117
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0117
818 50S ribosomal protein L10 rplJ 0.0115
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0115
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0114
6031 Cytochrome P450 3A43 CYP3A43 0.0114
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0113
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0113
504 Mast/stem cell growth factor receptor KIT 0.0113
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0113
1852 Microtubule-associated protein 2 MAP2 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0111
436 5-hydroxytryptamine 2B receptor HTR2B 0.0111
6167 Organic solute transporter subunit beta OSTB 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
6166 Organic solute transporter subunit alpha OSTA 0.011
4192 DNA topoisomerase 2-beta TOP2B 0.0109
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0109
4203 Histamine N-methyltransferase HNMT 0.0108
3639 Thymidine phosphorylase deoA 0.0108
3936 Thymidine phosphorylase TYMP 0.0108
146 Androgen receptor AR 0.0108
2443 Azurin azu 0.0108
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0108
696 Kappa-type opioid receptor OPRK1 0.0107
4237 50S ribosomal protein L22 rplV 0.0107
558 Solute carrier family 12 member 1 SLC12A1 0.0107
6085 Fatty acid-binding protein, intestinal FABP2 0.0105
624 Guanidinoacetate N-methyltransferase GAMT 0.0105
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0104
543 Penicillin-binding protein 1B mrcB 0.0104
6186 Penicillin-binding protein 1B ponB 0.0104
6822 Penicillin-binding protein 1b pbp1b 0.0104
6844 Penicillin-binding protein 1b pbp1b 0.0104
244 Angiotensin-converting enzyme ACE 0.0104
1517 Beta-3 adrenergic receptor ADRB3 0.0104
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0102
228 Beta platelet-derived growth factor receptor PDGFRB 0.0102
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.01
461 Glycine receptor subunit alpha-3 GLRA3 0.01
6210 Tubulin delta chain TUBD1 0.01
6212 Tubulin gamma-1 chain TUBG1 0.01
6211 Tubulin epsilon chain TUBE1 0.01
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
26 Vascular endothelial growth factor receptor 3 FLT4 0.0099
6014 Cytochrome P450 2A13 CYP2A13 0.0099
163 D(1B) dopamine receptor DRD5 0.0098
6182 Cytochrome P450 2J2 CYP2J2 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6043 Putative G-protein coupled receptor 44 GPR44 0.0097
6220 Aryl hydrocarbon receptor AHR 0.0097
4238 50S ribosomal protein L4 rplD 0.0096
5578 50S ribosomal protein L4 rplD 0.0096
6173 50S ribosomal protein L4 rplD 0.0096
6219 50S ribosomal protein L4 rplD 0.0096
1353 DNA topoisomerase 1 TOP1 0.0096
3552 DNA topoisomerase 1 topA 0.0096
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0095
6146 High affinity copper uptake protein 1 SLC31A1 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
32 Vascular endothelial growth factor receptor 1 FLT1 0.0095
5923 Microtubule-associated protein tau MAPT 0.0094
5924 Microtubule-associated protein 4 MAP4 0.0094
6126 Carbonic anhydrase 7 CA7 0.0094
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0093
33 Cystine/glutamate transporter SLC7A11 0.0093
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0092
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0092
332 Beta-lactamase blaZ 0.0092
2478 Beta-lactamase ampC 0.0092
2613 Beta-lactamase ampC 0.0092
2635 Beta-lactamase ampC 0.0092
2700 Beta-lactamase penP 0.0092
5445 Beta-lactamase blaB 0.0092
6019 Beta-lactamase SHV-7 0.0092
6701 Beta-lactamase cphA 0.0092
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
1192 Sulfotransferase 1A1 SULT1A1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
407 Vascular endothelial growth factor receptor 2 KDR 0.0091
828 Phenylalanine-4-hydroxylase PAH 0.009
3109 Phenylalanine-4-hydroxylase phhA 0.009
122 P2Y purinoceptor 12 P2RY12 0.009
2472 Voltage-gated potassium channel kcsA 0.009
6366 Voltage-gated potassium channel kcsA 0.009
896 Glutathione S-transferase Mu 1 GSTM1 0.009
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0089
6163 Copper-transporting ATPase 2 ATP7B 0.0088
6165 Copper-transporting ATPase 1 ATP7A 0.0088
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
2320 Thymidine kinase, cytosolic TK1 0.0086
3917 Methylenetetrahydrofolate reductase MTHFR 0.0085
2808 Chloramphenicol acetyltransferase 3 cat3 0.0085
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0084
702 UMP-CMP kinase CMPK1 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0083
16 Adenosine A1 receptor ADORA1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
2539 Tubulin alpha-1 chain TUBA4A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0082
489 Monocarboxylate transporter 2 SLC16A7 0.0081
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0081
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
756 Sex hormone-binding globulin SHBG 0.008
950 Alpha platelet-derived growth factor receptor PDGFRA 0.008
6138 Multidrug resistance protein 3 ABCB4 0.008
6218 Pannexin-1 PANX1 0.0079
1178 Adenosine A2a receptor ADORA2A 0.0079
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0079
1770 Phospholipase C PLCL1 0.0079
2841 Phospholipase C plc 0.0079
1050 Bile salt sulfotransferase SULT2A1 0.0077
6020 Aldehyde oxidase AOX1 0.0076
164 Histamine H4 receptor HRH4 0.0076
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0074
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0074
284 DNA-directed RNA polymerase beta chain rpoB 0.0074
5773 DNA-directed RNA polymerase beta chain rpoB 0.0074
3932 Glutathione S-transferase A2 GSTA2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
3810 Catechol O-methyltransferase COMT 0.0072
1341 Histamine H3 receptor HRH3 0.0072
6070 Nischarin NISCH 0.0071
5126 Arginase rocF 0.0071
992 Protein tyrosine kinase 2 beta PTK2B 0.0071
716 5-hydroxytryptamine 7 receptor HTR7 0.007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.007
183 Vascular endothelial growth factor A VEGFA 0.007
1650 Heme carrier protein 1 SLC46A1 0.007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0069
976 Platelet glycoprotein IX GP9 0.0069
6432 Transporter snf 0.0069
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0068
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0068
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0068
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0068
117 Sterol O-acyltransferase 1 SOAT1 0.0068
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0068
277 Purine nucleoside phosphorylase PNP 0.0066
2870 Purine nucleoside phosphorylase punA 0.0066
2945 Purine nucleoside phosphorylase punA 0.0066
4659 Purine nucleoside phosphorylase TM_1596 0.0066
4825 Purine nucleoside phosphorylase TTHA1435 0.0066
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0065
1830 5'-nucleotidase NT5E 0.0065
4122 Histone deacetylase 2 HDAC2 0.0064
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0064
571 Melatonin receptor type 1A MTNR1A 0.0064
362 Melatonin receptor type 1B MTNR1B 0.0064
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0063
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0063
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0063
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0063
3270 Elongation factor G fusA 0.0062
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0061
3587 Gastrotropin FABP6 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0061
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0059
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0059
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0059
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0059
694 Matrix protein 2 M 0.0059
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0059
6168 Solute carrier family 22 member 16 SLC22A16 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
1656 CYP2B protein CYP2B 0.0058
165 FL cytokine receptor FLT3 0.0058
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0057
527 Prostacyclin receptor PTGIR 0.0057
788 Creatine kinase M-type CKM 0.0057
751 Potassium channel subfamily K member 6 KCNK6 0.0057
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0057
2599 Tyrosine-protein kinase HCK HCK 0.0057
5787 Angiopoietin-1 receptor TEK 0.0056
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0056
511 5-hydroxytryptamine 1F receptor HTR1F 0.0056
672 Prostaglandin F2-alpha receptor PTGFR 0.0056
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0055
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0054
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0054
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0054
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0054
714 Glutathione reductase, mitochondrial GSR 0.0053
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0053
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0053
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0053
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0053
6044 Serum paraoxonase/lactonase 3 PON3 0.0052
811 Translocator protein TSPO 0.0052
172 Potassium channel subfamily K member 1 KCNK1 0.0052
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0052
6837 Serine/threonine-protein kinase 17B STK17B 0.0052
293 Gamma-glutamyl hydrolase GGH 0.0052
365 Dihydrofolate reductase DHFR 0.0052
2381 Dihydrofolate reductase DFR1 0.0052
2833 Dihydrofolate reductase Not Available 0.0052
2931 Dihydrofolate reductase folA 0.0052
3544 Dihydrofolate reductase folA 0.0052
3682 Dihydrofolate reductase folA 0.0052
6642 Dihydrofolate reductase folA 0.0052
6756 Dihydrofolate reductase dfrA 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
2981 Phospholipase A2, membrane associated PLA2G2A 0.0051
2300 Lysozyme E 0.0051
3633 Lysozyme R 0.0051
5597 Lysozyme 17 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.005
3611 Cytidine deaminase cdd 0.005
3707 Cytidine deaminase cdd 0.005
4211 Cytidine deaminase CDA 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0049
153 Dopamine beta-hydroxylase DBH 0.0049
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0049
4217 Telomerase reverse transcriptase TERT 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0048
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0047
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
125 DNA polymerase beta POLB 0.0047
683 Potassium transporter GK0582 0.0047
814 Ryanodine receptor 1 RYR1 0.0046
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0046
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0046
6102 Arylamine N-acetyltransferase 2 NAT2 0.0046
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0046
173 Toll-like receptor 7 TLR7 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
2232 Interleukin-5 IL5 0.0045
68 Cannabinoid receptor 1 CNR1 0.0045
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0045
1593 Mucin-2 MUC2 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0045
6131 Carbonic anhydrase 14 CA14 0.0044
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0044
291 Nitric-oxide synthase, endothelial NOS3 0.0044
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
65 Matrix metalloproteinase-9 Not Available 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
1010 Cytochrome P450 51A1 CYP51A1 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0042
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0042
1313 Lactoylglutathione lyase GLO1 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
921 Glutamate receptor 2 GRIA2 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
427 Substance-P receptor TACR1 0.0041
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0041
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0041
6122 Carbonic anhydrase 3 CA3 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0041
408 Riboflavin kinase RFK 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
1256 5-hydroxytryptamine 6 receptor HTR6 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
239 Coagulation factor X F10 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1618 High affinity nerve growth factor receptor NTRK1 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
5682 Ribonuclease pancreatic RNASE1 0.0039
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0039
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0039
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0039
3926 Choline transporter-like protein 2 SLC44A2 0.0039
769 High-affinity choline transporter 1 SLC5A7 0.0039
861 Choline kinase alpha CHKA 0.0039
3925 Choline transporter-like protein 4 SLC44A4 0.0039
3927 Choline transporter-like protein 3 SLC44A3 0.0039
1686 Choline transporter-like protein 1 SLC44A1 0.0039
700 Choline dehydrogenase, mitochondrial CHDH 0.0039
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0039
576 Choline O-acetyltransferase CHAT 0.0039
3922 Phospholipase D2 PLD2 0.0039
3924 Phospholipase D1 PLD1 0.0039
1760 Aminopeptidase N ANPEP 0.0039
6843 Aminopeptidase N pepN 0.0039
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0039
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0039
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
5818 Folate receptor alpha FOLR1 0.0038
6042 Prostaglandin reductase 2 PTGR2 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
740 Argininosuccinate synthase ASS1 0.0038
865 Argininosuccinate synthase ASS1 0.0038
2680 Argininosuccinate synthase argG 0.0038
3194 Argininosuccinate synthase argG 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
6228 Nuclear receptor coactivator 1 NCOA1 0.0037
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
6241 Nuclear receptor coactivator 2 NCOA2 0.0037
2021 Thrombomodulin THBD 0.0037
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0036
707 72 kDa type IV collagenase MMP2 0.0036
1867 Major prion protein PRNP 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4103 Proteasome subunit beta type 2 PSMB2 0.0035
4102 Proteasome subunit beta type 5 PSMB5 0.0035
4101 Proteasome subunit beta type 1 PSMB1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
1025 Aquaporin-1 AQP1 0.0035
3957 Adenosine deaminase ADA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
3007 Carbonic anhydrase 12 CA12 0.0034
4205 Carbonic anhydrase 9 CA9 0.0034
1039 Histone deacetylase 9 HDAC9 0.0034
94 5-hydroxytryptamine 4 receptor HTR4 0.0034
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
499 Arginine decarboxylase ADC 0.0033
130 Prostacyclin synthase PTGIS 0.0033
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
3809 Estrogen-related receptor gamma ESRRG 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0032
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0032
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0032
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
1864 RET proto-oncogene RET 0.0032
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0031
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0031
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
705 Glutamate receptor 1 GRIA1 0.0031
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0031
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0031
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
577 Argininosuccinate lyase ASL 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
1630 Integrin beta-2 ITGB2 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
6171 Solute carrier family 28 member 3 SLC28A3 0.003
780 Retinoic acid receptor RXR-gamma RXRG 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0029
654 Flavin reductase BLVRB 0.0029
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
319 Opioid receptor, sigma 1 OPRS1 0.0028
469 Annexin A1 ANXA1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
3426 Glutamine synthetase glnA 0.0027
3987 Glutamine synthetase GLUL 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
1196 Complement decay-accelerating factor CD55 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
3685 Catabolite gene activator crp 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
1648 Elastin ELN 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
49 Endothelin B receptor EDNRB 0.0026
6151 Monocarboxylate transporter 10 SLC16A10 0.0026
634 Squalene monooxygenase SQLE 0.0026
7196 Squalene monooxygenase ERG1 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
1792 Tissue-type plasminogen activator PLAT 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0025
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0025
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
4041 Microsomal glutathione S-transferase 2 MGST2 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
517 Alcohol dehydrogenase 1C ADH1C 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
482 Glycine receptor subunit alpha-1 GLRA1 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0023
4311 tRNA TRDMT1 0.0023
4325 tRNA trmD 0.0023
4328 tRNA trmD 0.0023
572 Integrin alpha-L ITGAL 0.0023
823 Fibroblast growth factor receptor 2 FGFR2 0.0023
1275 Estrogen sulfotransferase SULT1E1 0.0023
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
4760 Mll3241 protein mll3241 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0022
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
2417 Chloramphenicol acetyltransferase cat 0.0022
3278 Chloramphenicol acetyltransferase cat 0.0022
54 Prothrombin F2 0.0022
2810 Dr hemagglutinin structural subunit draA 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0022
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
2091 Endoplasmin HSP90B1 0.0021
6501 Fatty acid-binding protein, liver FABP1 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
76 Nitric-oxide synthase, brain NOS1 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
822 Aldose reductase AKR1B1 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
84 Nuclear receptor 0B1 NR0B1 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
4031 Glutathione S-transferase A1 GSTA1 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1654 Interleukin-1 beta IL1B 0.0019
518 Peroxidase/catalase T katG 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
6500 Phospholipase A2 PLA2G1B 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
229 Retinoic acid receptor beta RARB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
563 Thyroid peroxidase TPO 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
1243 Cathepsin D CTSD 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
494 Caspase-1 CASP1 0.0015
6755 Poliovirus receptor PVR 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
1507 Cytochrome c CYCS 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0015
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
207 Glutathione synthetase GSS 0.0013
5269 Glutathione synthetase gshB 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
2077 Caspase-3 CASP3 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0012
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0012
292 Activin receptor type-1 ACVR1 0.0012
1295 Fatty acid synthase FASN 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
6459 Glycodelin PAEP 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
997 Protein kinase C beta type PRKCB 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
268 Adenosine A2b receptor ADORA2B 0.001
1970 Protein kinase C alpha type PRKCA 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3830 Calreticulin CALR 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6677 Myelin P2 protein PMP2 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
798 Osteocalcin BGLAP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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