DT-Web

DB01118 - Amiodarone


Identification
Name Amiodarone
Accession Number DB01118 (APRD00288)
Type small molecule
Description An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 645.3116
Groups approved
Monoisotopic Weight 645.023680639
Pharmacology
Indication Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
Mechanism of action The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3) duration and refractory period and acts as a noncompetitive a- and b-adrenergic inhibitor.
Absorption Slow and variable (about 20 to 55% of an oral dose is absorbed).
Protein binding >96%
Biotransformation Amiodarone is extensively metabolized in the liver via CYP2C8 (under 1% unchanged in urine), and can effect the metabolism of numerous other drugs. The major metabolite of amiodarone is desethylamiodarone (DEA), which also has antiarrhythmic properties. The metabolism of amiodarone is inhibited by grapefruit juice, leading to elevated serum levels of amiodarone.
Route of elimination Amiodarone is eliminated primarily by hepatic metabolism and biliary excretion and there is negligible excretion of amiodarone or DEA in urine.
Toxicity Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Amiodarone may increase the anticoagulant effect of acenocoumarol.
Alvimopan Decreases levels by P-glycoprotein (MDR-1) efflux transporter. Can significantly increase systemic exposure to P-glycoprotein substrates.
Amprenavir The protease inhibitor, amprenavir, may increase the effect and toxicity of amiodarone.
Anisindione Amiodarone may increase the anticoagulant effect of anisindione.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir Increased risk of cardiotoxicity and arrhythmias.
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Increased risk of cardiotoxicity and arrhythmias
Colesevelam Bile Acid Sequestrants may decrease the bioavailability of Amiodarone. Consider alternative antilipemic agent. The risk of subtherapeutic amiodarone serum concentrations when such is being used for the treatment of malignant arrhythmias can be very large. The effect (ie, reduced risk) of separating doses of these agents is unknown. Amiodarone should be administered at least 1 hour before or 4 hours after colesevelam.1 Similar dosing with other agents seems warranted.
Cyclosporine Amiodarone may increase the therapeutic and adverse effects of cyclosporine.
Dabigatran etexilate Amiodarone may increase the serum concentration of dabigatran etexilate, resulting in increased risk of bleeding. Consider modifying therapy.
Dicumarol Amiodarone may increase the anticoagulant effect of dicumarol.
Digoxin Amiodarone may increase the effect of digoxin.
Dihydroquinidine barbiturate Increases the effect of quinidine
Diltiazem Increased risk of cardiotoxicity and arrhythmias
Eltrombopag Affects hepatic enzyme CYP2C9/10 metabolism, increases effect/level of eltrombopag.
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Ethotoin Increases the effect of hydantoin
Etravirine Amiodarone, when used concomitantly with etravirine, may decrease in serum concentration. If possible, monitoring for decreased amiodarone levels is recommended.
Etravirine Amiodarone, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. If possible, monitoring of amiodarone levels is recommended.
Fentanyl Possible bradycardia, hypotension
Fingolimod Pharmacodynamic synergist. Contraindicated. Increased risk of bradycardia, AV block, and torsade de pointes.
Flecainide Amiodarone may increase the effect and toxicity of flecainide
Fosamprenavir The protease inhibitor, fosamprenavir, may increase the effect and toxicity of amiodarone.
Fosphenytoin Amiodarone may increase the effect of fosphenytoin.
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Indacaterol Concomitant therapy with monoamine oxidase inhibitors, tricyclic antidepressants, or other drugs that prolong the QTc interval should be monitored closely. These drugs may potentiate the effect of adrenergic agonist on the cardiovascular system.
Indinavir Indinavir increases the effect and toxicity of amiodarone
Iohexol Increased risk of cardiotoxicity and arrhythmias
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephenytoin Increases the effect of hydantoin
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Moxifloxacin Increased risk of cardiotoxicity and arrhythmias
Nelfinavir Nelfinavir may increase the effect and toxicity of amiodarone.
Phenytoin Amiodarone may increase the therapeutic and adverse effects of phenytoin.
Procainamide Amiodarone may increase serum levels and toxicity of procainamide.
Quinidine Amiodarone may increase the effect of quinidine.
Quinidine barbiturate Increases the effect of qiunidine
Ranolazine Possible additive effect on QT prolongation
Rifampin Rifampin decreases the effect of amiodarone
Ritonavir Ritonavir increases the effect and toxicity of amiodarone
Roflumilast Increases roflumilast levels.
Saquinavir The protease inhibitor, saquinavir, may increase the effect and toxicity of amiodarone.
Simvastatin Increased risk of rhabdomyolysis
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen Amiodarone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Amiodarone, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Amiodarone is initiated, discontinued, or dose changed.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Telithromycin may reduce clearance of Amiodarone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amiodarone if Telithromycin is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Amiodarone. Concomitant therapy is contraindicated.
Tizanidine Amiodarone may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolterodine Amiodarone may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The p-glycoprotein inhibitor, Amiodarone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Amiodarone may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Amiodarone may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Amiodarone, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Amiodarone is initiated, discontinued or dose changed.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Vardenafil Increased risk of cardiotoxicity and arrhythmias
Verapamil Additive bradycardic effects may occur. One case report of sinus arrest has been reported. Monitor for changes in the therapeutic effect and signs of Verapamil toxicity if Amiodarone is initiated, discontinued or dose changed.
Voriconazole Additive QTc prolongation may occur. Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of amiodarone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of amiodarone if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin Amiodarone may increase the anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if amiodarone is initiated, discontinued or dose changed.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.
  • Grapefruit can significantly increase serum levels of this product.
  • Grapefruit and grapefruit juice should be avoided throughout treatment.

Targets


Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Wang SP, Wang JA, Luo RH, Cui WY, Wang H: Potassium channel currents in rat mesenchymal stem cells and their possible roles in cell proliferation. Clin Exp Pharmacol Physiol. 2008 Sep;35(9):1077-84. Epub 2008 May 25. - Pubmed
  • Varro A, Biliczki P, Iost N, Virag L, Hala O, Kovacs P, Matyus P, Papp JG: Theoretical possibilities for the development of novel antiarrhythmic drugs. Curr Med Chem. 2004 Jan;11(1):1-11. - Pubmed
  • Waldhauser KM, Brecht K, Hebeisen S, Ha HR, Konrad D, Bur D, Krahenbuhl S: Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues. Br J Pharmacol. 2008 Oct;155(4):585-95. Epub 2008 Jul 7. - Pubmed
DTHybrid score 0.2532
Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • Doggrell SA, Brown L: Present and future pharmacotherapy for heart failure. Expert Opin Pharmacother. 2002 Jul;3(7):915-30. - Pubmed
DTHybrid score 0.5552
Voltage-dependent T-type calcium channel subunit alpha-1H
Name Voltage-dependent T-type calcium channel subunit alpha-1H
Gene Name CACNA1H
Pharmacological action unknown
Actions inhibitor
References
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
  • Lewalter T, Pittrow D, Goette A, Kirch W, Hohnloser S: [Clinical pharmacology and electrophysiological properties of dronedarone] Dtsch Med Wochenschr. 2010 Mar;135 Suppl 2:S43-7. Epub 2010 Mar 10. - Pubmed
DTHybrid score 0.2191
Voltage-dependent calcium channel subunit alpha-2/delta-2
Name Voltage-dependent calcium channel subunit alpha-2/delta-2
Gene Name CACNA2D2
Pharmacological action yes
Actions inhibitor
References
  • Cohen CJ, Spires S, Van Skiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol. 1992 Oct;100(4):703-28. - Pubmed
  • Lewalter T, Pittrow D, Goette A, Kirch W, Hohnloser S: [Clinical pharmacology and electrophysiological properties of dronedarone] Dtsch Med Wochenschr. 2010 Mar;135 Suppl 2:S43-7. Epub 2010 Mar 10. - Pubmed
DTHybrid score 0.2392

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, Yokoi T: A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10. - Pubmed
DTHybrid score 0.9858
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Information Hyperlinked Over Proteins (iHOP) - - Website
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, Yokoi T: A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10. - Pubmed
DTHybrid score 0.4966
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7687
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6628
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6302
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5735
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3666
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5679
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4483

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor,inducer
References
  • Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed
  • Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. Eur J Pharm Sci. 2001 Feb;12(4):505-13. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
  • Tiberghien F, Loor F: Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs. 1996 Jul;7(5):568-78. - Pubmed
  • Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed
DTHybrid score 0.6539

Predictions


Id Partner name Gene Name Score
766 Beta-2 adrenergic receptor ADRB2 0.3053
6030 Cytochrome P450 2B6 CYP2B6 0.2721
6013 Cytochrome P450 2E1 CYP2E1 0.2412
5718 Cytochrome P450 2A6 CYP2A6 0.1729
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.1504
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1498
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.1369
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.1368
587 Serum albumin ALB 0.1364
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.1331
20 Prostaglandin G/H synthase 1 PTGS1 0.1287
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.1239
492 Histamine H1 receptor HRH1 0.1191
556 Alpha-1A adrenergic receptor ADRA1A 0.1184
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1089
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.103
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1011
6106 Cytochrome P450 2C18 CYP2C18 0.0948
824 Sodium-dependent serotonin transporter SLC6A4 0.0911
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0879
831 D(2) dopamine receptor DRD2 0.0875
6145 Solute carrier family 22 member 1 SLC22A1 0.0872
1517 Beta-3 adrenergic receptor ADRB3 0.0856
465 Calmodulin CALM1 0.0848
862 Multidrug resistance-associated protein 1 ABCC1 0.0838
1898 Cytochrome P450 1B1 CYP1B1 0.0833
6144 Solute carrier family 22 member 2 SLC22A2 0.0823
502 5-hydroxytryptamine 2A receptor HTR2A 0.0813
632 Alpha-1B adrenergic receptor ADRA1B 0.0808
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0801
320 5-hydroxytryptamine 1A receptor HTR1A 0.0786
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0761
1729 Solute carrier family 22 member 6 SLC22A6 0.0712
318 Alpha-2A adrenergic receptor ADRA2A 0.0707
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0674
290 Prostaglandin G/H synthase 2 PTGS2 0.0651
3811 Cytochrome P450 19A1 CYP19A1 0.0646
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0645
776 Bile salt export pump ABCB11 0.0615
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0601
789 Alpha-1D adrenergic receptor ADRA1D 0.0594
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0589
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0577
847 Mu-type opioid receptor OPRM1 0.0566
23 D(1A) dopamine receptor DRD1 0.0542
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0539
118 Organic cation/carnitine transporter 2 SLC22A5 0.0528
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0527
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0522
871 Glucocorticoid receptor NR3C1 0.052
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0519
817 DNA topoisomerase 2-alpha TOP2A 0.0517
3941 Amine oxidase [flavin-containing] A MAOA 0.0517
590 5-hydroxytryptamine 2C receptor HTR2C 0.0513
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0512
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0499
713 Sodium-dependent dopamine transporter SLC6A3 0.0497
885 5-hydroxytryptamine 1B receptor HTR1B 0.0494
6182 Cytochrome P450 2J2 CYP2J2 0.0491
16 Adenosine A1 receptor ADORA1 0.0489
136 Estrogen receptor ESR1 0.0484
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0483
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0474
6031 Cytochrome P450 3A43 CYP3A43 0.0461
341 5-hydroxytryptamine 3 receptor HTR3A 0.0457
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0453
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0447
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0444
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0443
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.044
467 Delta-type opioid receptor OPRD1 0.0438
731 HIV-1 protease HIV-1 protease 0.0436
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0433
6142 Solute carrier family 22 member 8 SLC22A8 0.0431
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0429
638 D(3) dopamine receptor DRD3 0.042
629 Alpha-2B adrenergic receptor ADRA2B 0.0414
6143 Solute carrier family 22 member 7 SLC22A7 0.041
696 Kappa-type opioid receptor OPRK1 0.0409
6147 Solute carrier family 22 member 3 SLC22A3 0.0409
260 Cytochrome P450 51 ERG11 0.0408
761 Cytochrome P450 51 ERG11 0.0408
3163 Cytochrome P450 51 cyp51 0.0408
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.04
2164 Multidrug resistance-associated protein 4 ABCC4 0.04
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0392
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.039
468 Cytochrome P450 4A11 CYP4A11 0.0385
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0379
378 Alpha-2C adrenergic receptor ADRA2C 0.0367
737 Mineralocorticoid receptor NR3C2 0.0356
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0354
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0348
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0345
833 Organic cation/carnitine transporter 1 SLC22A4 0.0344
3939 Amine oxidase [flavin-containing] B MAOB 0.0338
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0334
777 Tumor necrosis factor TNF 0.0326
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0319
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0318
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0318
233 Potassium channel subfamily K member 2 KCNK2 0.0312
6148 Multidrug resistance-associated protein 7 ABCC10 0.0296
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.029
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0283
725 5-hydroxytryptamine 1D receptor HTR1D 0.0281
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0279
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0277
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0274
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0274
614 Progesterone receptor PGR 0.0271
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.027
6048 Troponin C, skeletal muscle TNNC2 0.0269
122 P2Y purinoceptor 12 P2RY12 0.0265
844 Epidermal growth factor receptor EGFR 0.0261
36 Insulin receptor INSR 0.0258
3923 Cholinesterase BCHE 0.0256
477 DNA topoisomerase 4 subunit A parC 0.0253
886 DNA topoisomerase 4 subunit A parC 0.0253
6226 DNA topoisomerase 4 subunit A parC 0.0253
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0252
146 Androgen receptor AR 0.0252
404 DNA gyrase subunit A gyrA 0.0249
6224 DNA gyrase subunit A gyrA 0.0249
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0246
432 D(4) dopamine receptor DRD4 0.0243
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0238
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0238
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0238
504 Mast/stem cell growth factor receptor KIT 0.0229
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0227
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0222
94 5-hydroxytryptamine 4 receptor HTR4 0.0219
1024 Solute carrier family 22 member 11 SLC22A11 0.0217
380 Cytochrome P450 17A1 CYP17A1 0.0215
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0212
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0212
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0211
1256 5-hydroxytryptamine 6 receptor HTR6 0.0211
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0211
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.021
6014 Cytochrome P450 2A13 CYP2A13 0.021
70 Type-1 angiotensin II receptor AGTR1 0.0206
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0206
756 Sex hormone-binding globulin SHBG 0.0204
6220 Aryl hydrocarbon receptor AHR 0.0204
4604 Liver carboxylesterase 1 CES1 0.0203
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0203
124 Histamine H2 receptor HRH2 0.0203
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
436 5-hydroxytryptamine 2B receptor HTR2B 0.0202
811 Translocator protein TSPO 0.0201
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0198
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0197
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0197
6141 Sodium/bile acid cotransporter SLC10A1 0.0194
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0193
3810 Catechol O-methyltransferase COMT 0.0191
6136 Multidrug resistance-associated protein 5 ABCC5 0.0189
3086 Plasmepsin-2 Not Available 0.0188
6137 Multidrug resistance-associated protein 6 ABCC6 0.0187
891 Dihydropteroate synthase folP 0.0187
5359 Dihydropteroate synthase folP 0.0187
7175 Dihydropteroate synthase sulI 0.0187
1010 Cytochrome P450 51A1 CYP51A1 0.0186
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0185
716 5-hydroxytryptamine 7 receptor HTR7 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
228 Beta platelet-derived growth factor receptor PDGFRB 0.0181
407 Vascular endothelial growth factor receptor 2 KDR 0.0181
26 Vascular endothelial growth factor receptor 3 FLT4 0.018
4120 NADPH--cytochrome P450 reductase POR 0.0178
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0177
3947 Xanthine dehydrogenase/oxidase XDH 0.0177
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0173
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
751 Potassium channel subfamily K member 6 KCNK6 0.0172
32 Vascular endothelial growth factor receptor 1 FLT1 0.0171
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0171
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0171
232 Corticosteroid-binding globulin SERPINA6 0.0166
869 Estrogen receptor beta ESR2 0.0166
818 50S ribosomal protein L10 rplJ 0.0165
6102 Arylamine N-acetyltransferase 2 NAT2 0.0162
1178 Adenosine A2a receptor ADORA2A 0.0161
1757 Myeloperoxidase MPO 0.0161
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.016
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0158
161 Tubulin beta chain TUBB 0.0157
312 Tubulin beta chain TUB2 0.0157
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0157
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0157
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0157
172 Potassium channel subfamily K member 1 KCNK1 0.0157
6020 Aldehyde oxidase AOX1 0.0154
474 Acetylcholinesterase ACHE 0.0153
29 Tubulin beta-1 chain TUBB1 0.0153
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0152
952 Dipeptidyl peptidase 4 DPP4 0.0151
183 Vascular endothelial growth factor A VEGFA 0.015
295 Carbonic anhydrase 1 CA1 0.0149
1820 Beta-nerve growth factor NGF 0.0149
427 Substance-P receptor TACR1 0.0149
2449 Tubulin alpha-3 chain TUBA1A 0.0148
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0147
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0147
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0147
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0147
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
1656 CYP2B protein CYP2B 0.0143
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0143
163 D(1B) dopamine receptor DRD5 0.0142
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0142
373 Transthyretin TTR 0.0141
950 Alpha platelet-derived growth factor receptor PDGFRA 0.014
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.014
1192 Sulfotransferase 1A1 SULT1A1 0.0139
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0138
571 Melatonin receptor type 1A MTNR1A 0.0136
362 Melatonin receptor type 1B MTNR1B 0.0136
1374 Natriuretic peptides B NPPB 0.0136
1827 Gap junction alpha-1 protein GJA1 0.0135
1908 Vascular cell adhesion protein 1 VCAM1 0.0135
592 Carbonic anhydrase 4 CA4 0.0135
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0132
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0131
4203 Histamine N-methyltransferase HNMT 0.013
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.013
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0128
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0128
365 Dihydrofolate reductase DHFR 0.0128
2381 Dihydrofolate reductase DFR1 0.0128
2833 Dihydrofolate reductase Not Available 0.0128
2931 Dihydrofolate reductase folA 0.0128
3544 Dihydrofolate reductase folA 0.0128
3682 Dihydrofolate reductase folA 0.0128
6642 Dihydrofolate reductase folA 0.0128
6756 Dihydrofolate reductase dfrA 0.0128
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
2112 Toll-like receptor 9 TLR9 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
613 Atrial natriuretic peptide receptor A NPR1 0.0122
3076 Antigen 85-C fbpC 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.012
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.012
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0119
4122 Histone deacetylase 2 HDAC2 0.0117
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0117
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0117
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0117
131 Synaptic vesicular amine transporter SLC18A2 0.0116
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0116
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0116
48 Pyridoxal kinase PDXK 0.0116
528 5-hydroxytryptamine 1E receptor HTR1E 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
273 Apoptosis regulator Bcl-2 BCL2 0.0115
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0115
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0113
2539 Tubulin alpha-1 chain TUBA4A 0.0112
606 Cytochrome P450 27, mitochondrial CYP27A1 0.011
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.011
3932 Glutathione S-transferase A2 GSTA2 0.011
738 Monocarboxylate transporter 1 SLC16A1 0.0109
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0109
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0109
823 Fibroblast growth factor receptor 2 FGFR2 0.0108
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0108
6126 Carbonic anhydrase 7 CA7 0.0107
6085 Fatty acid-binding protein, intestinal FABP2 0.0106
814 Ryanodine receptor 1 RYR1 0.0106
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0106
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0106
4237 50S ribosomal protein L22 rplV 0.0106
4311 tRNA TRDMT1 0.0105
4325 tRNA trmD 0.0105
4328 tRNA trmD 0.0105
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0104
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0103
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0103
1050 Bile salt sulfotransferase SULT2A1 0.0103
1629 Transcription factor AP-1 JUN 0.0101
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0101
165 FL cytokine receptor FLT3 0.01
357 Carbonic anhydrase 2 CA2 0.01
768 FK506-binding protein 1A FKBP1A 0.01
239 Coagulation factor X F10 0.0099
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0098
828 Phenylalanine-4-hydroxylase PAH 0.0098
3109 Phenylalanine-4-hydroxylase phhA 0.0098
275 Arachidonate 5-lipoxygenase ALOX5 0.0098
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0097
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
33 Cystine/glutamate transporter SLC7A11 0.0096
469 Annexin A1 ANXA1 0.0096
88 Retinoic acid receptor RXR-beta RXRB 0.0095
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0094
4238 50S ribosomal protein L4 rplD 0.0094
5578 50S ribosomal protein L4 rplD 0.0094
6173 50S ribosomal protein L4 rplD 0.0094
6219 50S ribosomal protein L4 rplD 0.0094
84 Nuclear receptor 0B1 NR0B1 0.0093
6847 Lactase-phlorizin hydrolase LCT 0.0093
68 Cannabinoid receptor 1 CNR1 0.0092
921 Glutamate receptor 2 GRIA2 0.0092
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
1852 Microtubule-associated protein 2 MAP2 0.0091
976 Platelet glycoprotein IX GP9 0.0091
1176 Mitogen-activated protein kinase 1 MAPK1 0.0091
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0091
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.009
578 Endothelin-1 receptor EDNRA 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0089
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
2300 Lysozyme E 0.0087
3633 Lysozyme R 0.0087
5597 Lysozyme 17 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
319 Opioid receptor, sigma 1 OPRS1 0.0087
1618 High affinity nerve growth factor receptor NTRK1 0.0086
705 Glutamate receptor 1 GRIA1 0.0085
790 DNA polymerase subunit alpha B POLA2 0.0084
6432 Transporter snf 0.0084
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0083
4103 Proteasome subunit beta type 2 PSMB2 0.0083
4102 Proteasome subunit beta type 5 PSMB5 0.0083
4101 Proteasome subunit beta type 1 PSMB1 0.0083
6044 Serum paraoxonase/lactonase 3 PON3 0.0082
780 Retinoic acid receptor RXR-gamma RXRG 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
54 Prothrombin F2 0.008
24 Thymidylate synthase TMP1 0.008
359 Thymidylate synthase TYMS 0.008
2626 Thymidylate synthase thyA 0.008
2729 Thymidylate synthase thyA 0.008
5352 Thymidylate synthase THYA 0.008
6146 High affinity copper uptake protein 1 SLC31A1 0.008
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
1196 Complement decay-accelerating factor CD55 0.008
173 Toll-like receptor 7 TLR7 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6043 Putative G-protein coupled receptor 44 GPR44 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
511 5-hydroxytryptamine 1F receptor HTR1F 0.0076
284 DNA-directed RNA polymerase beta chain rpoB 0.0076
5773 DNA-directed RNA polymerase beta chain rpoB 0.0076
1541 Metalloproteinase mmp20 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
482 Glycine receptor subunit alpha-1 GLRA1 0.0074
856 Vitamin D3 receptor VDR 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0073
904 Glutathione S-transferase P GSTP1 0.0073
174 Sigma 1-type opioid receptor SIGMAR1 0.0073
820 Glycine receptor subunit alpha-2 GLRA2 0.0072
6131 Carbonic anhydrase 14 CA14 0.0071
1275 Estrogen sulfotransferase SULT1E1 0.0071
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
634 Squalene monooxygenase SQLE 0.0071
7196 Squalene monooxygenase ERG1 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.007
5934 Cytochrome P450 26A1 CYP26A1 0.007
162 Retinoic acid receptor gamma-1 RARG 0.007
581 Cytochrome P450 2R1 CYP2R1 0.007
518 Peroxidase/catalase T katG 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0069
7 Nitric oxide synthase, inducible NOS2 0.0068
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0068
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
106 Cannabinoid receptor 2 CNR2 0.0067
6122 Carbonic anhydrase 3 CA3 0.0067
6138 Multidrug resistance protein 3 ABCB4 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
1630 Integrin beta-2 ITGB2 0.0066
3856 Fibroblast growth factor receptor 3 FGFR3 0.0066
3809 Estrogen-related receptor gamma ESRRG 0.0066
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0065
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0065
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0065
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0065
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0065
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0065
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0064
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6134 Sodium channel subunit beta-3 SCN3B 0.0063
6133 Sodium channel subunit beta-2 SCN2B 0.0063
6129 Carbonic anhydrase-related protein 11 CA11 0.0063
6132 Sodium channel subunit beta-1 SCN1B 0.0063
6135 Sodium channel subunit beta-4 SCN4B 0.0063
6127 Carbonic anhydrase-related protein CA8 0.0063
6128 Carbonic anhydrase-related protein 10 CA10 0.0063
133 Dihydropterate synthase sulI 0.0063
2810 Dr hemagglutinin structural subunit draA 0.0062
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4773 Deoxycytidine kinase DCK 0.0062
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
4192 DNA topoisomerase 2-beta TOP2B 0.006
564 Cellular retinoic acid-binding protein 1 CRABP1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0058
936 Ephrin type-A receptor 2 EPHA2 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
569 Retinal dehydrogenase 2 ALDH1A2 0.0057
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0057
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0057
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0057
3957 Adenosine deaminase ADA 0.0056
1992 Vitamin D-binding protein GC 0.0056
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0056
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0055
6130 Carbonic anhydrase 13 CA13 0.0055
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0054
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0054
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0053
611 Retinal dehydrogenase 1 ALDH1A1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
719 Retinoic acid receptor responder protein 1 RARRES1 0.0052
770 Retinoic acid-induced protein 3 GPRC5A 0.0052
712 Tubulin alpha chain TUB1 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
267 Plasminogen activator inhibitor 1 SERPINE1 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
5787 Angiopoietin-1 receptor TEK 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.005
572 Integrin alpha-L ITGAL 0.005
563 Thyroid peroxidase TPO 0.0048
908 Glutathione S-transferase theta-1 GSTT1 0.0048
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
164 Histamine H4 receptor HRH4 0.0048
1864 RET proto-oncogene RET 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0047
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0046
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0046
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
6221 Steroid hormone receptor ERR1 ESRRA 0.0046
527 Prostacyclin receptor PTGIR 0.0045
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0044
1063 Signal transducer and activator of transcription 5B STAT5B 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
3830 Calreticulin CALR 0.0043
117 Sterol O-acyltransferase 1 SOAT1 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
268 Adenosine A2b receptor ADORA2B 0.0043
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6036 Eosinophil peroxidase EPX 0.0041
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0041
730 Retinoic acid receptor alpha RARA 0.004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
3937 Fatty-acid amide hydrolase FAAH 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.004
1360 Sphingomyelin phosphodiesterase SMPD1 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
251 Alcohol dehydrogenase 1A ADH1A 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
484 Tyrosine-protein kinase ABL2 ABL2 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0038
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0038
444 Alcohol dehydrogenase 1B ADH1B 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
85 Growth hormone receptor GHR 0.0038
6151 Monocarboxylate transporter 10 SLC16A10 0.0037
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0033
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0033
537 ATP synthase delta chain, mitochondrial ATP5D 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
517 Alcohol dehydrogenase 1C ADH1C 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0031
3917 Methylenetetrahydrofolate reductase MTHFR 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
1039 Histone deacetylase 9 HDAC9 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5798 Mitogen-activated protein kinase 11 MAPK11 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2320 Thymidine kinase, cytosolic TK1 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6163 Copper-transporting ATPase 2 ATP7B 0.0026
6165 Copper-transporting ATPase 1 ATP7A 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
6218 Pannexin-1 PANX1 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
822 Aldose reductase AKR1B1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
2207 Rhodopsin RHO 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
798 Osteocalcin BGLAP 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
3221 Cytochrome c4 cc4 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1507 Cytochrome c CYCS 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
4920 Peroxidase/catalase katG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
693 Hemoglobin subunit beta HBB 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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