DT-Web

DB01418 - Acenocoumarol


Identification
Name Acenocoumarol
Accession Number DB01418
Type small molecule
Description Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, XI and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 353.3255
Groups approved
Monoisotopic Weight 353.089937217
Pharmacology
Indication For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
Mechanism of action Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent clotting factors, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited resulting in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Absorption Rapidly absorbed orally with greater than 60% bioavailability. Peak plasma levels are attained 1 to 3 hours following oral administration.
Protein binding 98.7% protein bound, mainly to albumin
Biotransformation Extensively metabolized in the liver via oxidation forming two hydroxy metabolites and keto reduction producing two alcohol metabolites. Reduction of the nitro group produces an amino metabolite which is further transformed to an acetoamido metabolite. Metabolites do not appear to be pharmacologically active.
Route of elimination Mostly via the kidney as metabolites
Toxicity The onset and severity of the symptoms are dependent on the individual's sensitivity to oral anticoagulants, the severity of the overdosage, and the duration of treatment. Bleeding is the major sign of toxicity with oral anticoagulant drugs. The most frequent symptoms observed are: cutaneous bleeding (80%), haematuria (with renal colic) (52%), haematomas, gastrointestinal bleeding, haematemesis, uterine bleeding, epistaxis, gingival bleeding and bleeding into the joints. Further symptoms include tachycardia, hypotension, peripheral circulatory disorders due to loss of blood, nausea, vomiting, diarrhoea and abdominal pains.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetaminophen Acetaminophen may increase the anticoagulant effect of acenocoumarol. Monitor for changes in the therapeutic and adverse effects of acenocoumarol if acetaminophen is initiated, discontinued or dose changed.
Acetylsalicylic acid Acetylsalicylic acid increases the effect of the anticoagulant, acenocoumarol.
Allopurinol Allopurinol may increase the anticoagulant effect of acenocoumarol.
Aminoglutethimide Aminoglutethimide may decrease the anticoagulant effect of acenocoumarol.
Amiodarone Amiodarone may increase the anticoagulant effect of acenocoumarol.
Amprenavir Amprenavir may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Aprepitant Aprepitant may decrease the anticoagulant effect of acenocoumarol by decreasing its serum concentration.
Atazanavir The protease inhibitor, atazanavir, may increase the anticoagulant effect of acenocoumarol.
Azathioprine Azathioprine may decrease the anticoagulant effect of acenocoumarol.
Azithromycin Azithromycin may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Betamethasone The corticosteroid, betamethasone, alters the anticoagulant effect, acenocoumarol.
Bosentan Bosentan may decrease the anticoagulant effect of acenocoumarol by increasing its metabolism.
Butabarbital Barbiturates like butabarbital may increase the metabolism of Vitamin K Antagonists like acenocoumarol. onitor for decreased therapeutic effects of oral anticoagulants if a barbiturate is initiated/dose increased (anticoagulant dosage increases of 30% to 60% may be needed based on monitored PT), or increased effects if a barbiturate is discontinued/dose decreased. An increased frequency of PT monitoring should be considered for the period immediately following barbiturate initiation/dosage changes.
Butalbital Barbiturates such as butalbital may increase the metabolism of Vitamin K Antagonists such as acenocoumarol. Monitor for decreased therapeutic effects of oral anticoagulants if a barbiturate is initiated/dose increased (anticoagulant dosage increases of 30% to 60% may be needed based on monitored PT), or increased effects if a barbiturate is discontinued/dose decreased. An increased frequency of PT monitoring should be considered for the period immediately following barbiturate initiation/dosage changes.
Capecitabine Capecitabine may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Carbamazepine Carbamazepine may decrease the anticoagulant effect of acenocoumarol by decreasing its serum concentration.
Cefotetan The cephalosporin, cefotetan, may increase the anticoagulant effect of acenocoumarol.
Cefoxitin The cephalosporin, cefoxitin, may increase the anticoagulant effect of acenocoumarol.
Ceftriaxone The cephalosporin, ceftriaxone, may increase the anticoagulant effect of acenocoumarol.
Celecoxib Celecoxib may increase the anticoagulant effect of acenocoumarol.
Cholestyramine The bile acid sequestrant, cholestyramine, may decrease the anticoagulant effect of acenocoumarol by decreasing its absorption.
Cimetidine Cimetidine may increase the anticoagulant effect of acenocoumarol.
Ciprofloxacin The quinolone antibiotic, ciprofloxacin, may increase the anticoagulant effect of acenocoumarol.
Cisapride Cisapride may increase the anticoagulant effect of acenocoumarol.
Citalopram The SSRI, citalopram, increases the effect of anticoagulant, acenocoumarol.
Clarithromycin The macrolide, clarithromycin, may increase the anticoagulant effect of acenocoumarol.
Clofibrate The fibrate increases the anticoagulant effect
Colestipol The bile acid sequestrant, colestipol, may decrease the anticoagulant effect of acenocoumarol by decreasing its absorption.
Cyclophosphamide The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of acenocoumarol.
Danazol The androgen, danazol, may increase the anticoagulant effect of acenocoumarol.
Demeclocycline The tetracycline, demeclocycline, may increase the anticoagulant effect of acenocoumarol.
Dexamethasone The corticosteroid, dexamethasone, alters the anticoagulant effect, acenocoumarol.
Dextrothyroxine The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of acenocoumarol.
Dicloxacillin Dicloxacillin may decrease the anticoagulant effect of acenocoumarol.
Diflunisal The NSAID, diflunisal, may increase the anticoagulant effect of acenocoumarol.
Disulfiram Disulfiram may increase the anticoagulant effect of acenocoumarol.
Doxycycline The tetracycline, doxycycline, may increase the anticoagulant effect of acenocoumarol.
Erythromycin The macrolide, erythromycin, may increase the anticoagulant effect of acenocoumarol.
Ethchlorvynol Ethchlorvynol may decrease the anticoagulant effect of acenocoumarol.
Ethinyl Estradiol Increased thrombotic risk due to estrogen
Etodolac The NSAID, etodolac, may increase the anticoagulant effect or acenocoumarol.
Etoricoxib Etoricoxib may increase the anticoagulant effect of acenocoumarol.
Fenofibrate Fenofibrate may increase the anticoagulant effect of acenocoumarol.
Fenoprofen The NSAID, fenoprofen, may increase the anticoagulant effect of acenocoumarol.
Fluconazole Fluconazole may increase the serum concentration of acenocoumarol by decreasing its metabolism.
Fludrocortisone The corticosteroid, fludrocortisone, alters the anticoagulant effect, acenocoumarol.
Fluorouracil The antineoplasic agent, fluorouracil, may increase the anticoagulant effect of acenocoumarol.
Fluoxetine The SSRI, fluoxetine, increases the effect of anticoagulant, acenocoumarol.
Fluoxymesterone The androgen, fluoxymesterone, may increase the anticoagulant effect of acenocoumarol.
Flurbiprofen The NSAID, flurbiprofen, may increase the anticoagulant effect of acenocoumarol.
Fluvastatin Fluvastatin may increase the anticoagulant effect of acenocoumarol. Monitor for changes in the therapeutic and adverse effects of acenocoumarol if fluvastatin is initiated, discontinued or dose changed.
Fluvoxamine Fluvoxamine may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Fosamprenavir The protease inhibitor, fosamprenavir, may increase the anticoagulant effect of acenocoumarol.
Fosphenytoin Increased hydantoin levels and risk of bleeding
Gefitinib Gefitinib may increase the anticoagulant effect of acenocoumarol.
Gemcitabine Gemcitabine may increase the anticoagulant effect of acenocoumarol.
Gemfibrozil Gemfibrozil may increase the anticoagulant effect of acenocoumarol.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Glutethimide Glutethimide may decrease the anticoagulant effect of acenocoumarol.
Griseofulvin Griseofulvin may decrease the anticoagulant effect of acenocoumarol.
Hydrocortisone The corticosteroid, hydrocortisone, alters the anticoagulant effect, acenocoumarol.
Ibuprofen The NSAID, ibuprofen, may increase the anticoagulant effect of acenocoumarol.
Imatinib Imatinib may increase the anticoagulant effect of acenocoumarol.
Indinavir The protease inhibitor, indinavir, may increase the anticoagulant effect of acenocoumarol.
Indomethacin The NSAID, indomethacin, may increase the anticoagulant effect of acenocoumarol.
Isoniazid Isoniazid may increase the anticoagulant effect of acenocoumarol.
Itraconazole Itraconazole may increase the anticoagulant effect of acenocoumarol.
Ketoconazole Ketoconazole may increase the anticoagulant effect of acenocoumarol.
Ketoprofen The NSAID, ketoprofen, may increase the anticoagulant effect of acenocoumarol.
Ketorolac The NSAID, ketorolac, may increase the anticoagulant effect of acenocoumarol.
Leflunomide Leflunomide may increase the anticoagulant effect of acenocoumarol.
Levamisole Levamisole may increase the anticoagulant effect of acenocoumarol.
Levofloxacin The quinolone antibiotic, levofloxacin, may increase the anticoagulant effect of acenocoumarol.
Levothyroxine The thyroid hormone, levothyroxine, increase the anticoagulant effect of acenocoumarol.
Lovastatin Lovastatin may increase the anticoagulant effect of acenocoumarol. Monitor for changes in the therapeutic and adverse effects of acenocoumarol if lovastatin is initiated, discontinued or dose changed.
Lumiracoxib Lumiracoxib may increase the anticoagulant effect of acenocoumarol.
Medroxyprogesterone Medroxyprogesterone may increase the anticoagulant effect of acenocoumarol.
Mefenamic acid The NSAID, mefanamic acid, may increase the anticoagulant effect of acenocoumarol.
Mefloquine Mefloquine may increase the anticoagulant effect of acenocoumarol.
Meloxicam Meloxicam may increase the anticoagulant effect of acenocoumarol.
Mercaptopurine Mercaptopurine may decrease the anticoagulant effect of acenocoumarol.
Methimazole The antithyroid agent, methimazole, may decrease the anticoagulant effect of acenocoumarol.
Metronidazole Metronidazole may increase the anticoagulant effect of acenocoumarol.
Miconazole Miconazole may increase the serum concentration of acenocoumarol by decreasing its metabolism.
Minocycline The tetracycline, minocycline, may increase the anticoagulant effect of acenocoumarol.
Mitotane Mitotane may decrease the anticoagulant effect of acenocoumarol.
Moxifloxacin The quinolone antibiotic, moxifloxacin, may increase the anticoagulant effect of acenocoumarol.
Nabumetone The NSAID, nabumetone, may increase the anticoagulant effect of acenocoumarol.
Nalidixic Acid The quinolone antibiotic, nalidixic acid, may increase the anticoagulant effect of acenocoumarol.
Naproxen The NSAID, naproxen, may increase the anticoagulant effect of acenocoumarol.
Nelfinavir The protease inhibitor, nelfinavir, may increase the anticoagulant effect of acenocoumarol.
Nevirapine Nevirapine may decrease the anticoagulant effect of acenocoumarol.
Norfloxacin The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of acenocoumarol.
Ofloxacin The quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of acenocoumarol.
Orlistat Orlistat may increase the anticoagulant effect of acenocoumarol.
Oxaprozin The NSAID, oxaprozin, may increase the anticoagulant effect of acenocoumarol.
Oxyphenbutazone The NSAID, oxyphenbutazone, may increase the anticoagulant effect of acenocoumarol.
Paroxetine The SSRI, paroxetine, increases the effect of the anticoagulant, acenocoumarol.
Pentoxifylline Pentoxifylline may increase the anticoagulant effect of acenocoumarol.
Phenobarbital The barbiturate, phenobarbital, decreases the anticoagulant effect of acenocoumarol.
Phenylbutazone The NSAID, phenylbutazone, may increase the anticoagulant effect of acenocoumarol.
Phenytoin Increased hydantoin levels and risk of bleeding
Piroxicam The NSAID, piroxicam, may increase the anticoagulant effect of acenocoumarol.
Prednisolone The corticosteroid, prednisolone, alters the anticoagulant effect, acenocoumarol.
Prednisone The corticosteroid, prednisone, alters the anticoagulant effect, acenocoumarol.
Primidone The barbiturate, primidone, decreases the anticoagulant effect of acenocoumarol.
Propafenone Propafenone may increase the anticoagulant effect of acenocoumarol.
Propoxyphene Propoxyphene may increase the anticoagulant effect of acenocoumarol.
Propylthiouracil The anti-thyroid agent, propylthiouracil, may decrease the anticoagulant effect of acenocoumarol.
Quinidine Quinidine may increase the anticoagulant effect of acenocoumarol.
Quinine Quinine, a moderate CYP2C9 inhibitor, may increase the serum concentration of acenocoumarol by decreasing its metabolism via CYP2C9.
Ranitidine Ranitidine may increase the anticoagulant effect of acenocoumarol. (Conflicting evidence)
Rifabutin Rifabutin may decrease the anticoagulant effect of acenocoumarol by increasing its metabolism.
Rifampin Rifampin may decrease the anticoagulant effect of acenocoumarol by increasing its metabolism.
Sulindac The NSAID, sulindac, may increase the anticoagulant effect of acenocoumarol. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Tamoxifen Tamoxifen may increase the serum concentration of Acenocoumarol increasing the risk of bleeding. Concomitant therapy should be avoided.
Telithromycin Telithromycin may increase the anticoagulant effect of acenocoumarol.
Tenoxicam The NSAID, tenoxicam, may increase the anticoagulant effect of acenocoumarol.
Testolactone The androgen, Testolactone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testolactone is initiated, discontinued or dose changed.
Testosterone The androgen, Testosterone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
Testosterone Propionate The androgen, Testosterone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
Tetracycline Tetracycline may increase the anticoagulant effect of acenocoumarol.
Thiabendazole The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Acenocoumarol by decreasing Acenocoumarol metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Acenocoumarol if Thiabendazole is initiated, discontinued or dose changed.
Thiopental Thiopental may increase the metabolism of the Vitamin K antagonist, Acenocoumarol. Acenocoumarol dose adjustment may be required.
Tiaprofenic acid Increased risk of bleeding.
Tigecycline Tigecycline may increase the anticoagulant effect of acenocoumarol.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Acenocoumarol. Consider alternate therapy or monitor for changes in Acenocoumarol therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Tolmetin Increased risk of bleeding. Monitor for signs and symptoms of bleeding.
transdermal testosterone gel The androgen, Testosterone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Acenocoumarol. Monitor for increased bleeding during concomitant thearpy.
Triamcinolone The corticosteroid, triamcinolone, alters the anticoagulant effect, acenocoumarol.
Trimetrexate The anticoagulant effect of Acenocoumarol, a Vitamin K antagonist, may be altered by antineoplastics such as Trimetrexate. Monitor for changes in the anticoagulant effects of warfarin and other coumarin derivatives during concomitant use.
Zafirlukast Zafirlukast may inhibit the metabolism of the vitamin K antagonist Acenocoumarol and increase INR and risk of bleeding.
Food Interactions
  • High doses of vitamin A, C, E and K (e.g. avocado, green vegetables)

Targets


Vitamin K epoxide reductase complex subunit 1
Name Vitamin K epoxide reductase complex subunit 1
Gene Name VKORC1
Pharmacological action yes
Actions inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Bodin L, Verstuyft C, Tregouet DA, Robert A, Dubert L, Funck-Brentano C, Jaillon P, Beaune P, Laurent-Puig P, Becquemont L, Loriot MA: Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood. 2005 Jul 1;106(1):135-40. Epub 2005 Mar 24. - Pubmed
  • Gonzalez-Conejero R, Corral J, Roldan V, Ferrer F, Sanchez-Serrano I, Sanchez-Blanco JJ, Marin F, Vicente V: The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. J Thromb Haemost. 2007 Aug;5(8):1701-6. Epub 2007 May 21. - Pubmed
  • Montes R, Ruiz de Gaona E, Martinez-Gonzalez MA, Alberca I, Hermida J: The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Br J Haematol. 2006 Apr;133(2):183-7. - Pubmed
  • Rettie AE, Farin FM, Beri NG, Srinouanprachanh SL, Rieder MJ, Thijssen HH: A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9. Br J Clin Pharmacol. 2006 Nov;62(5):617-20. Epub 2006 Jul 21. - Pubmed
  • Schalekamp T, Brasse BP, Roijers JF, Chahid Y, van Geest-Daalderop JH, de Vries-Goldschmeding H, van Wijk EM, Egberts AC, de Boer A: VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. Clin Pharmacol Ther. 2006 Jul;80(1):13-22. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5069

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Stehle S, Kirchheiner J, Lazar A, Fuhr U: Pharmacogenetics of oral anticoagulants: a basis for dose individualization. Clin Pharmacokinet. 2008;47(9):565-94. - Pubmed
  • Bodin L, Verstuyft C, Tregouet DA, Robert A, Dubert L, Funck-Brentano C, Jaillon P, Beaune P, Laurent-Puig P, Becquemont L, Loriot MA: Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood. 2005 Jul 1;106(1):135-40. Epub 2005 Mar 24. - Pubmed
  • Gonzalez-Conejero R, Corral J, Roldan V, Ferrer F, Sanchez-Serrano I, Sanchez-Blanco JJ, Marin F, Vicente V: The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. J Thromb Haemost. 2007 Aug;5(8):1701-6. Epub 2007 May 21. - Pubmed
  • Montes R, Ruiz de Gaona E, Martinez-Gonzalez MA, Alberca I, Hermida J: The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Br J Haematol. 2006 Apr;133(2):183-7. - Pubmed
  • Rettie AE, Farin FM, Beri NG, Srinouanprachanh SL, Rieder MJ, Thijssen HH: A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9. Br J Clin Pharmacol. 2006 Nov;62(5):617-20. Epub 2006 Jul 21. - Pubmed
  • Schalekamp T, Brasse BP, Roijers JF, Chahid Y, van Geest-Daalderop JH, de Vries-Goldschmeding H, van Wijk EM, Egberts AC, de Boer A: VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. Clin Pharmacol Ther. 2006 Jul;80(1):13-22. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4733
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4008
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3854
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Ufer M: Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46. - Pubmed
  • Morales-Molina JA, Arrebola MA, Robles PA, Mangana JC: Possible interaction between topical terbinafine and acenocoumarol. Ann Pharmacother. 2009 Nov;43(11):1911-2. Epub 2009 Oct 20. - Pubmed
DTHybrid score 0.5647

Carriers


Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2686
4924 Cytochrome P450 2C8 CYP2C8 0.2309
1588 Multidrug resistance protein 1 ABCB1 0.2081
4118 Cytochrome P450 3A5 CYP3A5 0.1636
6030 Cytochrome P450 2B6 CYP2B6 0.1369
6013 Cytochrome P450 2E1 CYP2E1 0.1291
6024 Cytochrome P450 1A1 CYP1A1 0.1149
6107 Cytochrome P450 3A7 CYP3A7 0.1125
20 Prostaglandin G/H synthase 1 PTGS1 0.0962
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0824
5718 Cytochrome P450 2A6 CYP2A6 0.0817
2159 Quinone oxidoreductase CRYZ 0.0653
6106 Cytochrome P450 2C18 CYP2C18 0.0641
290 Prostaglandin G/H synthase 2 PTGS2 0.0608
1729 Solute carrier family 22 member 6 SLC22A6 0.0593
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0577
492 Histamine H1 receptor HRH1 0.0523
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0507
556 Alpha-1A adrenergic receptor ADRA1A 0.0501
824 Sodium-dependent serotonin transporter SLC6A4 0.0494
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0485
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0473
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0465
862 Multidrug resistance-associated protein 1 ABCC1 0.0453
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0452
502 5-hydroxytryptamine 2A receptor HTR2A 0.0439
6145 Solute carrier family 22 member 1 SLC22A1 0.0437
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0417
320 5-hydroxytryptamine 1A receptor HTR1A 0.0391
3811 Cytochrome P450 19A1 CYP19A1 0.036
831 D(2) dopamine receptor DRD2 0.0358
6144 Solute carrier family 22 member 2 SLC22A2 0.0351
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.035
632 Alpha-1B adrenergic receptor ADRA1B 0.0343
891 Dihydropteroate synthase folP 0.034
5359 Dihydropteroate synthase folP 0.034
7175 Dihydropteroate synthase sulI 0.034
6142 Solute carrier family 22 member 8 SLC22A8 0.0337
318 Alpha-2A adrenergic receptor ADRA2A 0.0333
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0332
36 Insulin receptor INSR 0.0325
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0318
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0318
789 Alpha-1D adrenergic receptor ADRA1D 0.0308
23 D(1A) dopamine receptor DRD1 0.0307
1898 Cytochrome P450 1B1 CYP1B1 0.0305
2164 Multidrug resistance-associated protein 4 ABCC4 0.0298
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0294
136 Estrogen receptor ESR1 0.0281
766 Beta-2 adrenergic receptor ADRB2 0.0279
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0277
3941 Amine oxidase [flavin-containing] A MAOA 0.0276
713 Sodium-dependent dopamine transporter SLC6A3 0.0275
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0262
590 5-hydroxytryptamine 2C receptor HTR2C 0.0261
731 HIV-1 protease HIV-1 protease 0.0257
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0255
6143 Solute carrier family 22 member 7 SLC22A7 0.0252
193 Beta-1 adrenergic receptor ADRB1 0.0247
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0247
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0239
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0237
118 Organic cation/carnitine transporter 2 SLC22A5 0.0236
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0232
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0225
1024 Solute carrier family 22 member 11 SLC22A11 0.0222
844 Epidermal growth factor receptor EGFR 0.0219
260 Cytochrome P450 51 ERG11 0.0219
761 Cytochrome P450 51 ERG11 0.0219
3163 Cytochrome P450 51 cyp51 0.0219
3939 Amine oxidase [flavin-containing] B MAOB 0.0218
341 5-hydroxytryptamine 3 receptor HTR3A 0.0213
871 Glucocorticoid receptor NR3C1 0.0213
847 Mu-type opioid receptor OPRM1 0.021
465 Calmodulin CALM1 0.0209
776 Bile salt export pump ABCB11 0.0204
885 5-hydroxytryptamine 1B receptor HTR1B 0.0202
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0196
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0195
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0194
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0194
122 P2Y purinoceptor 12 P2RY12 0.0193
817 DNA topoisomerase 2-alpha TOP2A 0.0187
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0186
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0182
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0176
696 Kappa-type opioid receptor OPRK1 0.0176
3923 Cholinesterase BCHE 0.0172
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0172
1389 Transforming growth factor beta-1 TGFB1 0.0169
6147 Solute carrier family 22 member 3 SLC22A3 0.0166
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0165
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0164
629 Alpha-2B adrenergic receptor ADRA2B 0.0163
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0162
70 Type-1 angiotensin II receptor AGTR1 0.0162
400 Coagulation factor IX F9 0.0161
5461 Coagulation factor IX F9 0.0161
725 5-hydroxytryptamine 1D receptor HTR1D 0.0158
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0158
183 Vascular endothelial growth factor A VEGFA 0.0157
604 Vitamin K-dependent protein Z PROZ 0.0157
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0154
467 Delta-type opioid receptor OPRD1 0.0152
468 Cytochrome P450 4A11 CYP4A11 0.0151
146 Androgen receptor AR 0.0148
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
833 Organic cation/carnitine transporter 1 SLC22A4 0.0139
1757 Myeloperoxidase MPO 0.0139
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0139
638 D(3) dopamine receptor DRD3 0.0138
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0138
6020 Aldehyde oxidase AOX1 0.0137
3947 Xanthine dehydrogenase/oxidase XDH 0.0135
378 Alpha-2C adrenergic receptor ADRA2C 0.0135
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0134
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0134
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0134
6031 Cytochrome P450 3A43 CYP3A43 0.0134
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0134
756 Sex hormone-binding globulin SHBG 0.0134
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0133
422 Vitamin K-dependent protein C PROC 0.0133
1245 Vitamin K-dependent protein S PROS1 0.0133
1517 Beta-3 adrenergic receptor ADRB3 0.0132
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0131
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.013
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0129
380 Cytochrome P450 17A1 CYP17A1 0.0126
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0125
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0124
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0122
6141 Sodium/bile acid cotransporter SLC10A1 0.012
1656 CYP2B protein CYP2B 0.0119
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0119
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0118
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0116
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0115
482 Glycine receptor subunit alpha-1 GLRA1 0.0114
4604 Liver carboxylesterase 1 CES1 0.0112
777 Tumor necrosis factor TNF 0.0111
811 Translocator protein TSPO 0.0111
432 D(4) dopamine receptor DRD4 0.011
3917 Methylenetetrahydrofolate reductase MTHFR 0.0109
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0109
614 Progesterone receptor PGR 0.0109
373 Transthyretin TTR 0.0107
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0107
6220 Aryl hydrocarbon receptor AHR 0.0106
436 5-hydroxytryptamine 2B receptor HTR2B 0.0106
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0106
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0106
798 Osteocalcin BGLAP 0.0105
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0103
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0103
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0103
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0103
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0103
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0102
124 Histamine H2 receptor HRH2 0.0102
818 50S ribosomal protein L10 rplJ 0.0102
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0101
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.01
239 Coagulation factor X F10 0.01
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.01
6182 Cytochrome P450 2J2 CYP2J2 0.01
1050 Bile salt sulfotransferase SULT2A1 0.0099
6102 Arylamine N-acetyltransferase 2 NAT2 0.0099
2211 Fatty acid-binding protein, heart FABP3 0.0098
705 Glutamate receptor 1 GRIA1 0.0098
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0097
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0096
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0096
49 Endothelin B receptor EDNRB 0.0096
6014 Cytochrome P450 2A13 CYP2A13 0.0096
566 Serotransferrin TF 0.0094
504 Mast/stem cell growth factor receptor KIT 0.0094
738 Monocarboxylate transporter 1 SLC16A1 0.0093
54 Prothrombin F2 0.0093
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0093
369 Coagulation factor VII F7 0.0093
6136 Multidrug resistance-associated protein 5 ABCC5 0.0092
6085 Fatty acid-binding protein, intestinal FABP2 0.0092
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
768 FK506-binding protein 1A FKBP1A 0.0088
537 ATP synthase delta chain, mitochondrial ATP5D 0.0088
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0088
6148 Multidrug resistance-associated protein 7 ABCC10 0.0088
16 Adenosine A1 receptor ADORA1 0.0088
6137 Multidrug resistance-associated protein 6 ABCC6 0.0087
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0087
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0087
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0087
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0087
869 Estrogen receptor beta ESR2 0.0086
1618 High affinity nerve growth factor receptor NTRK1 0.0086
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
716 5-hydroxytryptamine 7 receptor HTR7 0.0086
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0086
5787 Angiopoietin-1 receptor TEK 0.0086
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0085
228 Beta platelet-derived growth factor receptor PDGFRB 0.0084
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0084
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0083
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0083
6432 Transporter snf 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
407 Vascular endothelial growth factor receptor 2 KDR 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0078
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0078
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
163 D(1B) dopamine receptor DRD5 0.0077
295 Carbonic anhydrase 1 CA1 0.0077
357 Carbonic anhydrase 2 CA2 0.0077
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0076
6043 Putative G-protein coupled receptor 44 GPR44 0.0074
1178 Adenosine A2a receptor ADORA2A 0.0074
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0074
427 Substance-P receptor TACR1 0.0074
558 Solute carrier family 12 member 1 SLC12A1 0.0073
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0072
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0071
459 Retinoic acid receptor RXR-alpha RXRA 0.0071
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.007
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.007
26 Vascular endothelial growth factor receptor 3 FLT4 0.007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0069
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0068
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0067
32 Vascular endothelial growth factor receptor 1 FLT1 0.0067
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0066
275 Arachidonate 5-lipoxygenase ALOX5 0.0066
365 Dihydrofolate reductase DHFR 0.0066
2381 Dihydrofolate reductase DFR1 0.0066
2833 Dihydrofolate reductase Not Available 0.0066
2931 Dihydrofolate reductase folA 0.0066
3544 Dihydrofolate reductase folA 0.0066
3682 Dihydrofolate reductase folA 0.0066
6642 Dihydrofolate reductase folA 0.0066
6756 Dihydrofolate reductase dfrA 0.0066
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0065
94 5-hydroxytryptamine 4 receptor HTR4 0.0065
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0064
921 Glutamate receptor 2 GRIA2 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
528 5-hydroxytryptamine 1E receptor HTR1E 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0063
133 Dihydropterate synthase sulI 0.0063
3810 Catechol O-methyltransferase COMT 0.0062
1256 5-hydroxytryptamine 6 receptor HTR6 0.0062
1010 Cytochrome P450 51A1 CYP51A1 0.0062
4122 Histone deacetylase 2 HDAC2 0.0062
161 Tubulin beta chain TUBB 0.0062
312 Tubulin beta chain TUB2 0.0062
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0061
474 Acetylcholinesterase ACHE 0.0061
273 Apoptosis regulator Bcl-2 BCL2 0.006
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.006
780 Retinoic acid receptor RXR-gamma RXRG 0.0059
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
2183 Fatty acid-binding protein, adipocyte FABP4 0.0058
4120 NADPH--cytochrome P450 reductase POR 0.0057
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0056
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0056
284 DNA-directed RNA polymerase beta chain rpoB 0.0055
5773 DNA-directed RNA polymerase beta chain rpoB 0.0055
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0055
511 5-hydroxytryptamine 1F receptor HTR1F 0.0055
88 Retinoic acid receptor RXR-beta RXRB 0.0054
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0054
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0053
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
1864 RET proto-oncogene RET 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0052
712 Tubulin alpha chain TUB1 0.0052
29 Tubulin beta-1 chain TUBB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0052
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0052
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
613 Atrial natriuretic peptide receptor A NPR1 0.005
1502 Peroxisome proliferator-activated receptor delta PPARD 0.005
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0048
856 Vitamin D3 receptor VDR 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0046
814 Ryanodine receptor 1 RYR1 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
952 Dipeptidyl peptidase 4 DPP4 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0045
518 Peroxidase/catalase T katG 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
904 Glutathione S-transferase P GSTP1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0044
6044 Serum paraoxonase/lactonase 3 PON3 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
33 Cystine/glutamate transporter SLC7A11 0.0044
823 Fibroblast growth factor receptor 2 FGFR2 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
6103 Arylamine N-acetyltransferase 1 NAT1 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
1648 Elastin ELN 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1992 Vitamin D-binding protein GC 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.004
153 Dopamine beta-hydroxylase DBH 0.004
563 Thyroid peroxidase TPO 0.0039
1541 Metalloproteinase mmp20 0.0039
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0039
2981 Phospholipase A2, membrane associated PLA2G2A 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0038
85 Growth hormone receptor GHR 0.0038
737 Mineralocorticoid receptor NR3C2 0.0037
3426 Glutamine synthetase glnA 0.0037
3987 Glutamine synthetase GLUL 0.0037
1629 Transcription factor AP-1 JUN 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
5934 Cytochrome P450 26A1 CYP26A1 0.0036
594 Thyroxine-binding globulin SERPINA7 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
6146 High affinity copper uptake protein 1 SLC31A1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0034
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
758 Thyroid hormone receptor alpha THRA 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
1360 Sphingomyelin phosphodiesterase SMPD1 0.0033
751 Potassium channel subfamily K member 6 KCNK6 0.0032
65 Matrix metalloproteinase-9 Not Available 0.0032
3639 Thymidine phosphorylase deoA 0.0032
3936 Thymidine phosphorylase TYMP 0.0032
6677 Myelin P2 protein PMP2 0.0032
4311 tRNA TRDMT1 0.0032
4325 tRNA trmD 0.0032
4328 tRNA trmD 0.0032
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0032
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
1867 Major prion protein PRNP 0.0032
1714 Mitogen-activated protein kinase 3 MAPK3 0.0032
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
4217 Telomerase reverse transcriptase TERT 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
346 Thyroid hormone receptor beta-1 THRB 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
6174 50S ribosomal protein L32 rpmF 0.003
172 Potassium channel subfamily K member 1 KCNK1 0.003
162 Retinoic acid receptor gamma-1 RARG 0.003
1196 Complement decay-accelerating factor CD55 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0029
3957 Adenosine deaminase ADA 0.0029
6033 High affinity interleukin-8 receptor A CXCR1 0.0029
1192 Sulfotransferase 1A1 SULT1A1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0028
3937 Fatty-acid amide hydrolase FAAH 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
976 Platelet glycoprotein IX GP9 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
4210 Toll-like receptor 4 TLR4 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
229 Retinoic acid receptor beta RARB 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
4226 Uridine phosphorylase 2 UPP2 0.0026
730 Retinoic acid receptor alpha RARA 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
4252 Penicillin-binding protein 5 dacA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0025
164 Histamine H4 receptor HRH4 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2320 Thymidine kinase, cytosolic TK1 0.0024
4225 Uridine phosphorylase 1 UPP1 0.0024
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0024
6231 Pepsin A PGA3 0.0024
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3808 Dihydropteroate synthase 2 folP2 0.0023
3601 Dihydropteroate synthase 1 folP1 0.0023
3807 Dihydropteroate synthase 1 folP1 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
1291 cAMP response element-binding protein CREB1 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0022
413 Amidophosphoribosyltransferase PPAT 0.0022
2515 Amidophosphoribosyltransferase purF 0.0022
3714 Amidophosphoribosyltransferase purF 0.0022
165 FL cytokine receptor FLT3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
2021 Thrombomodulin THBD 0.0022
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
199 Monocarboxylate transporter 8 SLC16A2 0.0022
2232 Interleukin-5 IL5 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
444 Alcohol dehydrogenase 1B ADH1B 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6218 Pannexin-1 PANX1 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
2207 Rhodopsin RHO 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3809 Estrogen-related receptor gamma ESRRG 0.0021
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
244 Angiotensin-converting enzyme ACE 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
319 Opioid receptor, sigma 1 OPRS1 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
1820 Beta-nerve growth factor NGF 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
822 Aldose reductase AKR1B1 0.002
1630 Integrin beta-2 ITGB2 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0019
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0019
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0018
1253 Interferon gamma IFNG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
683 Potassium transporter GK0582 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
1039 Histone deacetylase 9 HDAC9 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0017
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0017
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
174 Sigma 1-type opioid receptor SIGMAR1 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
4773 Deoxycytidine kinase DCK 0.0017
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0017
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0017
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
908 Glutathione S-transferase theta-1 GSTT1 0.0016
6042 Prostaglandin reductase 2 PTGR2 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
1243 Cathepsin D CTSD 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
268 Adenosine A2b receptor ADORA2B 0.0015
3233 Bile acid receptor NR1H4 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1792 Tissue-type plasminogen activator PLAT 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
3856 Fibroblast growth factor receptor 3 FGFR3 0.0015
469 Annexin A1 ANXA1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
572 Integrin alpha-L ITGAL 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
1341 Histamine H3 receptor HRH3 0.0014
267 Plasminogen activator inhibitor 1 SERPINE1 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6859 Protein S100-A4 S100A4 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6459 Glycodelin PAEP 0.0013
1313 Lactoylglutathione lyase GLO1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0012
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.001
4948 Cytochrome c-553 Not Available 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
6228 Nuclear receptor coactivator 1 NCOA1 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2298 Cytochrome P450-cam camC 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3221 Cytochrome c4 cc4 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4943 Cytochrome c6 petJ 0.0006
4916 Cyanoglobin glbN 0.0006
5000 HemO hemO 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4984 Neuroglobin NGB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4909 CooA protein cooA 0.0006
4961 Hemophore HasA hasA 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4972 P450cin cinA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
5961 Insulin INS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4920 Peroxidase/catalase katG 0.0004
6524 Protein tonB tonB 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
358 Cystathionine beta-synthase CBS 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
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