DT-Web: DB01101

Identification

Name

Capecitabine

Accession Number

DB01101 (APRD00203)

Type

small molecule

Description

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

359.3501

Groups

approved

Monoisotopic Weight

359.149263656

Pharmacology

Indication

For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.

Mechanism of action

Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase, an enzyme found in higher concentrations in many tumors compared to normal tissues or plasma. Fluorouracil is further metabolized to two active metabolites, 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), within normal and tumour cells. These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2'-deaxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, therefore a deficiency of this compound can inhibit cell division. Secondly, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis through the production of fraudulent RNA.

Absorption

Readily absorbed through the GI tract (~70%)

Protein binding

< 60% (mainly albumin)

Biotransformation

Metabolized by thymidine phosphorylase to fluoruracil.

Route of elimination

Capecitabine and its metabolites are predominantly excreted in urine; 95.5% of administered capecitabine dose is recovered in urine. Fecal excretion is minimal (2.6%). The major metabolite excreted in urine is FBAL which represents 57% of the administered dose.About 3% of the administered dose is excreted in urine as unchanged drug.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Capecitabine may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Anisindione	Capecitabine may increase the anticoagulant effect of anisindione by increasing its serum concentration.
Dicumarol	Capecitabine may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Ethotoin	Capecitabine increases the effect of hydantoin
Fosphenytoin	Capecitabine increases the effect of hydantoin
Mephenytoin	Capecitabine increases the effect of hydantoin
Phenytoin	Capecitabine increases the effect of hydantoin
Tamoxifen	Capecitabine may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Capecitabine is initiated, discontinued or dose changed.
Tolbutamide	Capecitabine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Capecitabine is initiated, discontinued or dose changed.
Torasemide	Capecitabine, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Capecitabine is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trimethoprim	The strong CYP2C9 inhibitor, Capecitabine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Capecitabine is initiated, discontinued or dose changed.
Voriconazole	Capecitabine, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if capecitabine is initiated, discontinued or dose changed.
Warfarin	Capecitabine may increase the serum concentration of warfarin by decreasing its metabolism. Monitor for changes in prothrombin time and therapeutic effects of warfarin if capecitabine is initiated or discontinued. Subsequent cycles of capecitabine may increase this effect.
Zafirlukast	Capecitabine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if capecitabine is initiated, discontinued or dose changed.

Food Interactions

Take 12 hours apart, within 30 minutes of the end of breakfast and dinner to reduce nausea.

Thymidylate synthase
Name	Thymidylate synthase
Gene Name	TYMS
Pharmacological action	yes
Actions	inhibitor
References	Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. - Pubmed Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. - Pubmed Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, Rogatko A, Wang H, Blanchard RL: UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005 Feb 1;11(3):1226-36. - Pubmed Li KM, Rivory LP, Clarke SJ: Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 5;820(1):121-30. Epub 2005 Apr 19. - Pubmed Fischel JL, Ciccolini J, Formento P, Ferrero JM, Milano G: Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine. Anticancer Drugs. 2006 Aug;17(7):807-13. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.8245
DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	incorporation into and destabilization
References	Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. - Pubmed Thomas DM, Zalcberg JR: 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95. - Pubmed Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. - Pubmed Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. - Pubmed Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. - Pubmed Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. - Pubmed
DTHybrid score	Not Available
RNA
Name	RNA
Gene Name	Not Available
Pharmacological action	yes
Actions	incorporation into and destabilization
References	Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. - Pubmed Thomas DM, Zalcberg JR: 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Clin Exp Pharmacol Physiol. 1998 Nov;25(11):887-95. - Pubmed Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. - Pubmed Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. - Pubmed Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. - Pubmed Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. - Pubmed
DTHybrid score	Not Available

Thymidine phosphorylase
Name	Thymidine phosphorylase
Gene Name	TYMP
Actions	substrate
References	de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. - Pubmed Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. - Pubmed Blanquicett C, Gillespie GY, Nabors LB, Miller CR, Bharara S, Buchsbaum DJ, Diasio RB, Johnson MR: Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45. - Pubmed Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine] Yakugaku Zasshi. 1999 Dec;119(12):881-97. - Pubmed Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. - Pubmed Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. - Pubmed Schuller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E, Reigner B: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol. 2000;45(4):291-7. - Pubmed Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. - Pubmed Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. - Pubmed Fischel JL, Ciccolini J, Formento P, Ferrero JM, Milano G: Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine. Anticancer Drugs. 2006 Aug;17(7):807-13. - Pubmed Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. - Pubmed
DTHybrid score	0.7972
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Actions	substrate
References	de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. - Pubmed Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. - Pubmed Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine] Yakugaku Zasshi. 1999 Dec;119(12):881-97. - Pubmed Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. - Pubmed Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. - Pubmed
DTHybrid score	0.6005
Dihydropyrimidine dehydrogenase [NADP+]
Name	Dihydropyrimidine dehydrogenase [NADP+]
Gene Name	DPYD
Actions	substrate
References	Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. - Pubmed Blanquicett C, Gillespie GY, Nabors LB, Miller CR, Bharara S, Buchsbaum DJ, Diasio RB, Johnson MR: Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45. - Pubmed de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. - Pubmed Gross E, Seck K, Neubauer S, Mayr J, Hellebrand H, Ratanaphan A, Lutz V, Stockinger H, Kiechle M: High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism. Int J Oncol. 2003 Feb;22(2):325-32. - Pubmed Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. - Pubmed Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. - Pubmed Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, Francis GL: Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. Cancer Chemother Pharmacol. 2004 May;53(5):409-14. - Pubmed Eliason JF, Megyeri A: Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets. 2004 May;5(4):383-8. - Pubmed Walko CM, Lindley C: Capecitabine: a review. Clin Ther. 2005 Jan;27(1):23-44. - Pubmed
DTHybrid score	0.8351
Cytidine deaminase
Name	Cytidine deaminase
Gene Name	CDA
Actions	substrate
References	de Bono JS, Twelves CJ: The oral fluorinated pyrimidines. Invest New Drugs. 2001;19(1):41-59. - Pubmed Tsukamoto Y, Kato Y, Ura M, Horii I, Ishitsuka H, Kusuhara H, Sugiyama Y: A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res. 2001 Aug;18(8):1190-202. - Pubmed Ishitsuka H, Shimma N, Horii I: [Discovery and development of novel anticancer drug capecitabine] Yakugaku Zasshi. 1999 Dec;119(12):881-97. - Pubmed Ishitsuka H: Capecitabine: preclinical pharmacology studies. Invest New Drugs. 2000 Nov;18(4):343-54. - Pubmed Endo M, Miwa M, Eda H, Ura M, Tanimura H, Ishikawa T, Miyazaki-Nose T, Hattori K, Shimma N, Yamada-Okabe H, Ishitsuka H: Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. - Pubmed
DTHybrid score	0.7497
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2576

Id	Partner name	Gene Name	Score
24	Thymidylate synthase	TMP1	0.8245
2626	Thymidylate synthase	thyA	0.8245
2729	Thymidylate synthase	thyA	0.8245
5352	Thymidylate synthase	THYA	0.8245
3639	Thymidine phosphorylase	deoA	0.7972
3611	Cytidine deaminase	cdd	0.7497
3707	Cytidine deaminase	cdd	0.7497
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.1337
4512	Cytochrome P450 3A4	CYP3A4	0.098
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0903
4924	Cytochrome P450 2C8	CYP2C8	0.0847
2320	Thymidine kinase, cytosolic	TK1	0.0823
1729	Solute carrier family 22 member 6	SLC22A6	0.0822
338	DNA polymerase	UL30	0.0801
379	DNA polymerase	UL54	0.0801
697	DNA polymerase	ORF28	0.0801
2482	DNA polymerase	43	0.0801
4104	DNA polymerase	BALF5	0.0801
6016	Cytochrome P450 2C19	CYP2C19	0.0767
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0745
1588	Multidrug resistance protein 1	ABCB1	0.0727
4773	Deoxycytidine kinase	DCK	0.0714
4200	Cytochrome P450 1A2	CYP1A2	0.0583
4119	Cytochrome P450 2D6	CYP2D6	0.0562
6148	Multidrug resistance-associated protein 7	ABCC10	0.0505
365	Dihydrofolate reductase	DHFR	0.0473
2381	Dihydrofolate reductase	DFR1	0.0473
2833	Dihydrofolate reductase	Not Available	0.0473
2931	Dihydrofolate reductase	folA	0.0473
3544	Dihydrofolate reductase	folA	0.0473
3682	Dihydrofolate reductase	folA	0.0473
6642	Dihydrofolate reductase	folA	0.0473
6756	Dihydrofolate reductase	dfrA	0.0473
3496	Uracil-DNA glycosylase	UL2	0.0469
3512	Uracil-DNA glycosylase	ung	0.0469
5257	Uracil-DNA glycosylase	udg	0.0469
6272	Uracil-DNA glycosylase	UNG	0.0469
5258	Pyrimidine-nucleoside phosphorylase	pdp	0.0469
2164	Multidrug resistance-associated protein 4	ABCC4	0.0449
587	Serum albumin	ALB	0.0438
2344	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0404
3706	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0404
702	UMP-CMP kinase	CMPK1	0.0392
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0381
4226	Uridine phosphorylase 2	UPP2	0.037
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0368
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0365
6030	Cytochrome P450 2B6	CYP2B6	0.0364
6171	Solute carrier family 28 member 3	SLC28A3	0.036
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0348
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0348
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
2826	Glucose--fructose oxidoreductase	gfo	0.0347
1830	5'-nucleotidase	NT5E	0.0344
5718	Cytochrome P450 2A6	CYP2A6	0.0343
2675	Pteridine reductase 1	PTR1	0.0343
4118	Cytochrome P450 3A5	CYP3A5	0.0343
4225	Uridine phosphorylase 1	UPP1	0.0341
20	Prostaglandin G/H synthase 1	PTGS1	0.0341
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0338
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0336
125	DNA polymerase beta	POLB	0.0333
6013	Cytochrome P450 2E1	CYP2E1	0.0329
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0324
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0315
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0315
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0301
413	Amidophosphoribosyltransferase	PPAT	0.029
2515	Amidophosphoribosyltransferase	purF	0.029
3714	Amidophosphoribosyltransferase	purF	0.029
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0289
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0283
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0267
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0257
6143	Solute carrier family 22 member 7	SLC22A7	0.0244
6107	Cytochrome P450 3A7	CYP3A7	0.0229
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0226
6136	Multidrug resistance-associated protein 5	ABCC5	0.021
290	Prostaglandin G/H synthase 2	PTGS2	0.0203
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.02
6145	Solute carrier family 22 member 1	SLC22A1	0.0197
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0195
6144	Solute carrier family 22 member 2	SLC22A2	0.0191
6142	Solute carrier family 22 member 8	SLC22A8	0.0178
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0174
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0173
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0165
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0163
6024	Cytochrome P450 1A1	CYP1A1	0.0158
2567	Thymidylate synthase thyX	thyX	0.0154
862	Multidrug resistance-associated protein 1	ABCC1	0.0145
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0143
122	P2Y purinoceptor 12	P2RY12	0.0139
2178	Metabotropic glutamate receptor 5	GRM5	0.0136
4275	PCZA361.16	Not Available	0.0128
4276	DNA polymerase III subunit epsilon	dnaQ	0.0128
2410	Deoxyuridine 5'-triphosphate nucleotidohydrolase	dut	0.0127
2490	Deoxyuridine 5'-triphosphate nucleotidohydrolase	dut	0.0127
244	Angiotensin-converting enzyme	ACE	0.0125
1141	Sialidase-1	NEU1	0.012
64	Neuraminidase	NA	0.012
641	Neuraminidase	NA	0.012
2676	Neuraminidase	NA	0.012
3026	Neuraminidase	NA	0.012
3519	Neuraminidase	NA	0.012
6007	Neuraminidase	NA	0.012
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0119
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0118
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0116
6106	Cytochrome P450 2C18	CYP2C18	0.0116
2555	Pol polyprotein	pol	0.0114
3242	Pol polyprotein	gag-pol	0.0114
3471	Pol polyprotein	gag-pro-pol	0.0114
5256	Pol polyprotein	pol	0.0114
6469	Pol polyprotein	gag-pol	0.0114
6565	Pol polyprotein	Not Available	0.0114
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0104
891	Dihydropteroate synthase	folP	0.0103
5359	Dihydropteroate synthase	folP	0.0103
7175	Dihydropteroate synthase	sulI	0.0103
5482	Sialidase-2	NEU2	0.0102
2251	Thymidylate kinase	tmk	0.0098
2254	Thymidylate kinase	DTYMK	0.0098
3522	Thymidylate kinase	tmk	0.0098
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
54	Prothrombin	F2	0.0097
232	Corticosteroid-binding globulin	SERPINA6	0.0095
492	Histamine H1 receptor	HRH1	0.0094
136	Estrogen receptor	ESR1	0.009
509	Thymidine kinase	TK	0.0085
570	Thymidine kinase	TK	0.0085
2559	Thymidine kinase	TK	0.0085
3430	Thymidine kinase	tdk	0.0085
3518	Thymidine kinase	TK	0.0085
5301	Thymidine kinase	tdk	0.0085
5771	Thymidine kinase	ORF36	0.0085
7009	Thymidine kinase	ORF36	0.0085
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0084
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.0084
3361	Serpin B5	SERPINB5	0.0084
5694	Transcription antiterminator licT	licT	0.0084
871	Glucocorticoid receptor	NR3C1	0.0083
776	Bile salt export pump	ABCB11	0.008
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0078
1024	Solute carrier family 22 member 11	SLC22A11	0.0077
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0077
1898	Cytochrome P450 1B1	CYP1B1	0.0076
3811	Cytochrome P450 19A1	CYP19A1	0.0074
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
824	Sodium-dependent serotonin transporter	SLC6A4	0.0071
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.007
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0068
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0067
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0067
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0067
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0067
70	Type-1 angiotensin II receptor	AGTR1	0.0067
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0064
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0064
1757	Myeloperoxidase	MPO	0.0064
2286	Isocitrate dehydrogenase [NADP]	icd	0.0063
2302	Isocitrate dehydrogenase [NADP]	icd	0.0063
2771	Isocitrate dehydrogenase [NADP]	icd	0.0063
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0063
133	Dihydropterate synthase	sulI	0.0063
118	Organic cation/carnitine transporter 2	SLC22A5	0.0063
4116	Dihydropteroate synthetase	Not Available	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
4534	Cytohesin-2	CYTH2	0.0061
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.006
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0059
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0059
3668	Maltose-binding periplasmic protein precursor	malE	0.0059
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0058
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0058
2324	Botulinum neurotoxin type B	botB	0.0057
3547	Enterotoxin type B	entB	0.0057
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0057
2058	P-selectin	SELP	0.0056
551	Carnitine O-acetyltransferase	CRAT	0.0056
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0056
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0056
3941	Amine oxidase [flavin-containing] A	MAOA	0.0056
4120	NADPH--cytochrome P450 reductase	POR	0.0055
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0055
3939	Amine oxidase [flavin-containing] B	MAOB	0.0054
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0054
6141	Sodium/bile acid cotransporter	SLC10A1	0.0054
3947	Xanthine dehydrogenase/oxidase	XDH	0.0054
731	HIV-1 protease	HIV-1 protease	0.0053
2592	Beta-galactosidase	lacZ	0.0053
76	Nitric-oxide synthase, brain	NOS1	0.0052
6147	Solute carrier family 22 member 3	SLC22A3	0.0052
6168	Solute carrier family 22 member 16	SLC22A16	0.0051
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0051
5201	FMN-binding protein	DvMF_2023	0.0051
5197	Trp repressor binding protein WrbA, putative	DR_A0214	0.0051
5178	Protein nrdI	nrdI	0.0051
5200	NADH dehydrogenase	nox	0.0051
5131	PhzG	phzG	0.0051
3293	Flavodoxin	Not Available	0.0051
4614	Flavodoxin	DVU_2680	0.0051
5172	Flavodoxin	isiB	0.0051
5173	Flavodoxin	isiB	0.0051
5182	Flavodoxin	fldA	0.0051
5193	Phenazine biosynthesis protein phzG	phzG	0.0051
5198	Flavodoxin-1	fldA	0.0051
5179	Probable aromatic acid decarboxylase	pad1	0.0051
5175	Hypothetical protein SMU.260	SMU_260	0.0051
5202	Nitroreductase family protein	BC_1844	0.0051
2586	Isopentenyl-diphosphate Delta-isomerase	idi	0.0051
5187	Isopentenyl-diphosphate delta-isomerase	fni	0.0051
5199	Isopentenyl-diphosphate delta-isomerase	fni	0.0051
5191	Morphinone reductase	morB	0.0051
5190	Rubredoxin-oxygen oxidoreductase	roo	0.0051
5181	Hypothetical protein yhdA	azr	0.0051
5170	Epidermin decarboxylase	epiD	0.0051
4405	Nitric oxide reductase	fprA	0.0051
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.005
315	Arginase-1	ARG1	0.005
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.005
2570	Tetanus toxin	tetX	0.0049
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0048
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0047
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0047
833	Organic cation/carnitine transporter 1	SLC22A4	0.0047
4503	NADPH-flavin oxidoreductase	frp	0.0046
5189	Trimethylamine dehydrogenase	tmd	0.0046
4836	Ferredoxin-dependent glutamate synthase 2	gltS	0.0046
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0046
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0046
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0046
3810	Catechol O-methyltransferase	COMT	0.0046
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0045
6137	Multidrug resistance-associated protein 6	ABCC6	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
3680	Dihydroorotate dehydrogenase A	pyrDA	0.0045
5176	YtnJ	moxC	0.0044
4407	FMN-dependent NADH-azoreductase	azoR	0.0044
5169	FMN-dependent NADH-azoreductase	azoR	0.0044
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0044
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0044
5206	Phosphopantothenoylcysteine decarboxylase	PPCDC	0.0044
3507	Chorismate synthase	aroC	0.0044
5171	Chorismate synthase	aroC	0.0044
713	Sodium-dependent dopamine transporter	SLC6A3	0.0044
49	Endothelin B receptor	EDNRB	0.0044
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0043
2723	Cholera enterotoxin subunit B	ctxB	0.0042
2775	Dihydroorotate dehydrogenase	pyrD	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
6608	Serine/threonine-protein kinase Sgk1	SGK1	0.0041
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0041
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0041
590	5-hydroxytryptamine 2C receptor	HTR2C	0.004
831	D(2) dopamine receptor	DRD2	0.004
1353	DNA topoisomerase 1	TOP1	0.004
3552	DNA topoisomerase 1	topA	0.004
2981	Phospholipase A2, membrane associated	PLA2G2A	0.004
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.004
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0039
408	Riboflavin kinase	RFK	0.0039
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0039
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0039
869	Estrogen receptor beta	ESR2	0.0039
5180	L(+)-mandelate dehydrogenase	mdlB	0.0038
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0038
1192	Sulfotransferase 1A1	SULT1A1	0.0038
738	Monocarboxylate transporter 1	SLC16A1	0.0038
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0037
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0037
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0037
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0037
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0037
260	Cytochrome P450 51	ERG11	0.0037
761	Cytochrome P450 51	ERG11	0.0037
3163	Cytochrome P450 51	cyp51	0.0037
130	Prostacyclin synthase	PTGIS	0.0037
5818	Folate receptor alpha	FOLR1	0.0037
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0037
3923	Cholinesterase	BCHE	0.0036
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0036
295	Carbonic anhydrase 1	CA1	0.0036
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0036
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0036
1275	Estrogen sulfotransferase	SULT1E1	0.0036
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0035
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0035
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0035
592	Carbonic anhydrase 4	CA4	0.0035
6042	Prostaglandin reductase 2	PTGR2	0.0035
4284	Pentaerythritol tetranitrate reductase	onr	0.0034
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0034
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0034
5122	Mersacidin decarboxylase	mrsD	0.0034
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0034
526	Thioredoxin reductase	trxB	0.0034
3767	Thioredoxin reductase	trxB	0.0034
5095	Putidaredoxin reductase	camA	0.0034
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0034
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0034
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0034
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0034
5081	L-aspartate oxidase	nadB	0.0034
5111	Phenylacetone monooxygenase	pamO	0.0034
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0034
1410	Oxidoreductase	HSD17B6	0.0034
4725	Oxidoreductase	Not Available	0.0034
5124	Oxidoreductase	Not Available	0.0034
5115	FkbI	fkbI	0.0034
3133	UDP-galactopyranose mutase	glf	0.0034
5099	UDP-galactopyranose mutase	glf	0.0034
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0034
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0034
5083	Cryptochrome DASH	cry	0.0034
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0034
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0034
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0034
5109	Outer membrane protein p64k or PM-6	m-6	0.0034
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0034
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0033
6268	Hydroxyacid oxidase 1	HAO1	0.0033
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0033
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0033
847	Mu-type opioid receptor	OPRM1	0.0033
696	Kappa-type opioid receptor	OPRK1	0.0033
6031	Cytochrome P450 3A43	CYP3A43	0.0033
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0033
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0032
654	Flavin reductase	BLVRB	0.0032
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0032
146	Androgen receptor	AR	0.0032
293	Gamma-glutamyl hydrolase	GGH	0.0032
556	Alpha-1A adrenergic receptor	ADRA1A	0.0032
811	Translocator protein	TSPO	0.0032
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
468	Cytochrome P450 4A11	CYP4A11	0.0031
632	Alpha-1B adrenergic receptor	ADRA1B	0.0031
2391	Ferrochelatase	hemH	0.0031
6502	Ferrochelatase	DKFZp686P18130	0.0031
1591	Ferrochelatase, mitochondrial	FECH	0.0031
467	Delta-type opioid receptor	OPRD1	0.0031
6043	Putative G-protein coupled receptor 44	GPR44	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
766	Beta-2 adrenergic receptor	ADRB2	0.0031
4486	Phenol 2-hydroxylase component B	pheA2	0.0031
4439	Ferredoxin reductase	bphA4	0.0031
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0031
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0031
5117	Dihydrolipoyl dehydrogenase	lpd	0.0031
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0031
3809	Estrogen-related receptor gamma	ESRRG	0.003
465	Calmodulin	CALM1	0.003
3594	Deoxyribodipyrimidine photo-lyase	phr	0.003
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.003
5080	Deoxyribodipyrimidine photo-lyase	phr	0.003
318	Alpha-2A adrenergic receptor	ADRA2A	0.003
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.003
2470	Pyruvate oxidase	pox5	0.0029
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0029
5073	Ferredoxin--NADP reductase	petH	0.0029
5076	Ferredoxin--NADP reductase	fpr	0.0029
5119	Ferredoxin--NADP reductase	petH	0.0029
5121	Ferredoxin--NADP reductase	fpr	0.0029
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0029
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0029
2526	NADPH-ferredoxin reductase fprA	fprA	0.0029
5072	N,N-dimethylglycine oxidase	dmg	0.0029
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0029
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0029
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0029
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0029
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0029
2268	Cholesterol oxidase	choB	0.0029
2822	Cholesterol oxidase	choA	0.0029
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
3102	Flavohemoprotein	hmp	0.0029
4969	Flavohemoprotein	hmp	0.0029
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0029
1650	Heme carrier protein 1	SLC46A1	0.0029
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0028
4440	NADH peroxidase	npr	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1313	Lactoylglutathione lyase	GLO1	0.0028
6102	Arylamine N-acetyltransferase 2	NAT2	0.0027
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0027
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0027
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0027
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0027
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0027
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0027
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0027
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0027
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0027
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0027
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0027
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0027
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0027
6559	Cytochrome c oxidase subunit 2	ctaC	0.0027
6669	Cytochrome c oxidase subunit 2	ctaC	0.0027
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0027
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0027
6558	Cytochrome c oxidase subunit 1	ctaD	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0027
2893	Glycine oxidase	thiO	0.0027
23	D(1A) dopamine receptor	DRD1	0.0027
571	Melatonin receptor type 1A	MTNR1A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
6085	Fatty acid-binding protein, intestinal	FABP2	0.0026
817	DNA topoisomerase 2-alpha	TOP2A	0.0026
357	Carbonic anhydrase 2	CA2	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0026
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0026
2823	Trypanothione reductase	TPR	0.0025
427	Substance-P receptor	TACR1	0.0025
275	Arachidonate 5-lipoxygenase	ALOX5	0.0025
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0025
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0025
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0025
605	Fumarate reductase flavoprotein subunit	frdA	0.0025
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0025
3673	Fumarate reductase flavoprotein subunit	fccA	0.0025
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0025
6549	Fumarate reductase flavoprotein subunit	frdA	0.0025
3587	Gastrotropin	FABP6	0.0025
327	Glutathione reductase	gor	0.0025
5110	Glutathione reductase	GR2	0.0025
2540	Choloylglycine hydrolase	cbh	0.0025
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0025
1541	Metalloproteinase	mmp20	0.0025
126	D-lactate dehydrogenase	dld	0.0025
3545	D-lactate dehydrogenase	Not Available	0.0025
4510	D-lactate dehydrogenase	ldhA	0.0025
2769	P-hydroxybenzoate hydroxylase	pobA	0.0024
2809	P-hydroxybenzoate hydroxylase	pobA	0.0024
482	Glycine receptor subunit alpha-1	GLRA1	0.0024
183	Vascular endothelial growth factor A	VEGFA	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0024
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0024
6501	Fatty acid-binding protein, liver	FABP1	0.0024
2380	Monomeric sarcosine oxidase	soxA	0.0023
459	Retinoic acid receptor RXR-alpha	RXRA	0.0023
94	5-hydroxytryptamine 4 receptor	HTR4	0.0023
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0023
6182	Cytochrome P450 2J2	CYP2J2	0.0023
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0023
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0022
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0022
6645	D-amino-acid oxidase	DAO	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0022
407	Vascular endothelial growth factor receptor 2	KDR	0.0021
517	Alcohol dehydrogenase 1C	ADH1C	0.0021
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0021
780	Retinoic acid receptor RXR-gamma	RXRG	0.0021
4203	Histamine N-methyltransferase	HNMT	0.0021
6020	Aldehyde oxidase	AOX1	0.0021
153	Dopamine beta-hydroxylase	DBH	0.002
6220	Aryl hydrocarbon receptor	AHR	0.002
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.002
4878	Glycoprotein hormones alpha chain	CGA	0.002
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.002
1072	Granzyme B	GZMB	0.002
4877	Beta-mannanase	man	0.002
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.002
4850	Beta-2-glycoprotein 1	APOH	0.002
4856	CD209 antigen	CD209	0.002
4889	Ig epsilon chain C region	IGHE	0.002
4869	Major capsid protein	A430L	0.002
4852	Reticulon-4 receptor	RTN4R	0.002
4880	Membrane cofactor protein	CD46	0.002
757	Fusion glycoprotein F0	F	0.002
4875	Fusion glycoprotein F0	F	0.002
4721	Beta-1,4-mannanase	manA	0.002
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.002
1354	Beta-glucuronidase	GUSB	0.002
442	Envelope glycoprotein	gp41	0.002
4859	Envelope glycoprotein	env	0.002
4189	Alpha-galactosidase A	GLA	0.002
4845	ADAM 33	ADAM33	0.002
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.002
3352	Structural polyprotein	Not Available	0.002
3628	Structural polyprotein	Not Available	0.002
4892	Structural polyprotein	Not Available	0.002
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
777	Tumor necrosis factor	TNF	0.0019
504	Mast/stem cell growth factor receptor	KIT	0.0019
789	Alpha-1D adrenergic receptor	ADRA1D	0.0018
714	Glutathione reductase, mitochondrial	GSR	0.0018
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0018
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0018
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0018
6858	Inactive carboxylesterase 4	CES1P1	0.0017
793	T-cell surface antigen CD2	CD2	0.0017
4861	Interleukin-6 receptor alpha chain	IL6R	0.0017
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0017
3837	Cytokine receptor common beta chain	CSF2RB	0.0017
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0016
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0016
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0016
4890	Hemagglutinin	HA	0.0016
6566	Hemagglutinin	Not Available	0.0016
1379	Interleukin-12 subunit beta	IL12B	0.0016
6014	Cytochrome P450 2A13	CYP2A13	0.0016
1648	Elastin	ELN	0.0015
1184	Interferon beta	IFNB1	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0015
1656	CYP2B protein	CYP2B	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
558	Solute carrier family 12 member 1	SLC12A1	0.0015
380	Cytochrome P450 17A1	CYP17A1	0.0015
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0015
2297	Genome polyprotein	Not Available	0.0015
2322	Genome polyprotein	Not Available	0.0015
2694	Genome polyprotein	Not Available	0.0015
2719	Genome polyprotein	Not Available	0.0015
2860	Genome polyprotein	Not Available	0.0015
2928	Genome polyprotein	Not Available	0.0015
3160	Genome polyprotein	Not Available	0.0015
3260	Genome polyprotein	Not Available	0.0015
4783	Genome polyprotein	Not Available	0.0015
5726	Genome polyprotein	Not Available	0.0015
5779	Genome polyprotein	Not Available	0.0015
5867	Genome polyprotein	Not Available	0.0015
6253	Genome polyprotein	Not Available	0.0015
6301	Genome polyprotein	Not Available	0.0015
6380	Genome polyprotein	Not Available	0.0015
6381	Genome polyprotein	Not Available	0.0015
6437	Genome polyprotein	Not Available	0.0015
6520	Genome polyprotein	Not Available	0.0015
6521	Genome polyprotein	Not Available	0.0015
6652	Genome polyprotein	Not Available	0.0015
6734	Genome polyprotein	Not Available	0.0015
6735	Genome polyprotein	Not Available	0.0015
6736	Genome polyprotein	Not Available	0.0015
6737	Genome polyprotein	Not Available	0.0015
6738	Genome polyprotein	Not Available	0.0015
6739	Genome polyprotein	Not Available	0.0015
6744	Genome polyprotein	Not Available	0.0015
6748	Genome polyprotein	Not Available	0.0015
6894	Genome polyprotein	Not Available	0.0015
6898	Genome polyprotein	Not Available	0.0015
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0015
1010	Cytochrome P450 51A1	CYP51A1	0.0014
756	Sex hormone-binding globulin	SHBG	0.0014
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0014
614	Progesterone receptor	PGR	0.0014
629	Alpha-2B adrenergic receptor	ADRA2B	0.0014
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0014
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0014
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0014
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0014
921	Glutamate receptor 2	GRIA2	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0014
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0014
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0014
1859	Prostatic acid phosphatase	ACPP	0.0014
3140	Hemagglutinin-neuraminidase	HN	0.0014
3609	Hemagglutinin-neuraminidase	HN	0.0014
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0014
3444	Cyanovirin-N	Not Available	0.0014
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0014
554	Low-density lipoprotein receptor	LDLR	0.0014
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0014
852	Heparin cofactor 2	SERPIND1	0.0014
2232	Interleukin-5	IL5	0.0014
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0014
1593	Mucin-2	MUC2	0.0014
4787	Envelope glycoprotein gp160	env	0.0013
4820	Envelope glycoprotein gp160	env	0.0013
5727	Envelope glycoprotein gp160	env	0.0013
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0013
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0013
595	Fibrinogen alpha chain	FGA	0.0013
4666	Fucose-binding lectin PA-IIL	lecB	0.0013
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0013
2372	Bifunctional tail protein	9	0.0013
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0013
823	Fibroblast growth factor receptor 2	FGFR2	0.0013
2207	Rhodopsin	RHO	0.0013
6103	Arylamine N-acetyltransferase 1	NAT1	0.0013
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0012
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0012
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0012
124	Histamine H2 receptor	HRH2	0.0012
958	Insulin-like growth factor 1 receptor	IGF1R	0.0012
193	Beta-1 adrenergic receptor	ADRB1	0.0012
29	Tubulin beta-1 chain	TUBB1	0.0012
518	Peroxidase/catalase T	katG	0.0012
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0012
6149	Solute carrier family 22 member 10	SLC22A10	0.0011
474	Acetylcholinesterase	ACHE	0.0011
1243	Cathepsin D	CTSD	0.0011
164	Histamine H4 receptor	HRH4	0.0011
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0011
1439	Lactotransferrin	LTF	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0011
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0011
3814	Complement C1r subcomponent	C1R	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
638	D(3) dopamine receptor	DRD3	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0011
106	Cannabinoid receptor 2	CNR2	0.0011
432	D(4) dopamine receptor	DRD4	0.0011
2430	Chondroitinase B	cslB	0.0011
1629	Transcription factor AP-1	JUN	0.0011
6174	50S ribosomal protein L32	rpmF	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
1196	Complement decay-accelerating factor	CD55	0.001
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
6307	Ig gamma-2 chain C region	IGHG2	0.001
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.001
2581	Chondroitinase AC	cslA	0.001
309	Antithrombin-III	SERPINC1	0.001
6146	High affinity copper uptake protein 1	SLC31A1	0.001
6847	Lactase-phlorizin hydrolase	LCT	0.001
68	Cannabinoid receptor 1	CNR1	0.001
563	Thyroid peroxidase	TPO	0.001
6138	Multidrug resistance protein 3	ABCB4	0.001
952	Dipeptidyl peptidase 4	DPP4	0.001
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.001
4122	Histone deacetylase 2	HDAC2	0.001
16	Adenosine A1 receptor	ADORA1	0.001
1178	Adenosine A2a receptor	ADORA2A	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.001
634	Squalene monooxygenase	SQLE	0.0009
7196	Squalene monooxygenase	ERG1	0.0009
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0009
716	5-hydroxytryptamine 7 receptor	HTR7	0.0009
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
2808	Chloramphenicol acetyltransferase 3	cat3	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0009
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
4785	Ig gamma-1 chain C region	IGHG1	0.0009
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0008
273	Apoptosis regulator Bcl-2	BCL2	0.0008
3808	Dihydropteroate synthase 2	folP2	0.0008
3601	Dihydropteroate synthase 1	folP1	0.0008
3807	Dihydropteroate synthase 1	folP1	0.0008
2417	Chloramphenicol acetyltransferase	cat	0.0008
3278	Chloramphenicol acetyltransferase	cat	0.0008
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0008
2810	Dr hemagglutinin structural subunit	draA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0008
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0008
26	Vascular endothelial growth factor receptor 3	FLT4	0.0008
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0008
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0008
581	Cytochrome P450 2R1	CYP2R1	0.0008
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0008
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0008
32	Vascular endothelial growth factor receptor 1	FLT1	0.0008
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0008
3830	Calreticulin	CALR	0.0008
161	Tubulin beta chain	TUBB	0.0008
312	Tubulin beta chain	TUB2	0.0008
1992	Vitamin D-binding protein	GC	0.0007
319	Opioid receptor, sigma 1	OPRS1	0.0007
4948	Cytochrome c-553	Not Available	0.0007
4923	Cytochrome c3	DvMF_2499	0.0007
4945	Cytochrome c3	Not Available	0.0007
4949	Cytochrome c3	DVU_3171	0.0007
4968	Cytochrome c3	cytc3	0.0007
4997	Cytochrome c3	SO_2727	0.0007
5219	Cytochrome c3	cyd	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
4902	Nine-heme cytochrome c	Ddes_2038	0.0007
3189	High-molecular-weight cytochrome c	hmcA	0.0007
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0007
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0007
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
737	Mineralocorticoid receptor	NR3C2	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0007
976	Platelet glycoprotein IX	GP9	0.0007
1630	Integrin beta-2	ITGB2	0.0007
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
373	Transthyretin	TTR	0.0007
1374	Natriuretic peptides B	NPPB	0.0007
1827	Gap junction alpha-1 protein	GJA1	0.0007
1908	Vascular cell adhesion protein 1	VCAM1	0.0007
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0007
4217	Telomerase reverse transcriptase	TERT	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0006
239	Coagulation factor X	F10	0.0006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0006
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0006
4386	Hemoglobin-like protein HbN	glbN	0.0006
251	Alcohol dehydrogenase 1A	ADH1A	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
705	Glutamate receptor 1	GRIA1	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
378	Alpha-2C adrenergic receptor	ADRA2C	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
828	Phenylalanine-4-hydroxylase	PAH	0.0006
3109	Phenylalanine-4-hydroxylase	phhA	0.0006
163	D(1B) dopamine receptor	DRD5	0.0006
6044	Serum paraoxonase/lactonase 3	PON3	0.0006
3221	Cytochrome c4	cc4	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
33	Cystine/glutamate transporter	SLC7A11	0.0005
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0005
444	Alcohol dehydrogenase 1B	ADH1B	0.0005
856	Vitamin D3 receptor	VDR	0.0005
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0005
7	Nitric oxide synthase, inducible	NOS2	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0005
572	Integrin alpha-L	ITGAL	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
5924	Microtubule-associated protein 4	MAP4	0.0005
5923	Microtubule-associated protein tau	MAPT	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
267	Plasminogen activator inhibitor 1	SERPINE1	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
1852	Microtubule-associated protein 2	MAP2	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0005
1507	Cytochrome c	CYCS	0.0005
1268	Neuropeptide S receptor	NPSR1	0.0005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6218	Pannexin-1	PANX1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0005
6221	Steroid hormone receptor ERR1	ESRRA	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0005
751	Potassium channel subfamily K member 6	KCNK6	0.0004
1039	Histone deacetylase 9	HDAC9	0.0004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0004
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0004
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
3937	Fatty-acid amide hydrolase	FAAH	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
172	Potassium channel subfamily K member 1	KCNK1	0.0004
936	Ephrin type-A receptor 2	EPHA2	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
165	FL cytokine receptor	FLT3	0.0004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0004
5787	Angiopoietin-1 receptor	TEK	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0004
3957	Adenosine deaminase	ADA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
162	Retinoic acid receptor gamma-1	RARG	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
908	Glutathione S-transferase theta-1	GSTT1	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
469	Annexin A1	ANXA1	0.0004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0004
284	DNA-directed RNA polymerase beta chain	rpoB	0.0004
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0003
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0003
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0003
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0003
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0003
896	Glutathione S-transferase Mu 1	GSTM1	0.0003
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
904	Glutathione S-transferase P	GSTP1	0.0003
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0003
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0003
489	Monocarboxylate transporter 2	SLC16A7	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0003
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0002
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0002
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0002
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0002
4954	Soluble cytochrome b558	Not Available	0.0002
4916	Cyanoglobin	glbN	0.0002
4934	Cytochrome c-551	nirM	0.0002
5218	Cytochrome c-551	nirM	0.0002
4947	Bacterial hemoglobin	vhb	0.0002
4915	Cytochrome c-550	psbV	0.0002
4959	Cytochrome c-550	psbV	0.0002
5216	Cytochrome c-550	psbV	0.0002
4925	Cytochrome c-type protein SHP	shp	0.0002
4998	Hemoglobin-like protein yjbI	yjbI	0.0002
4905	Cytochrome c2	Not Available	0.0002
4939	Cytochrome c2	cycA	0.0002
4964	Cytochrome c2	cycA	0.0002
4979	Cytochrome c2	cycA	0.0002
6673	Cytochrome c2	cycA	0.0002
5000	HemO	hemO	0.0002
4975	Cytochrome c-556	RPA3973	0.0002
4984	Neuroglobin	NGB	0.0002
4943	Cytochrome c6	petJ	0.0002
4910	Cytoglobin	CYGB	0.0002
4907	Cytochrome c-L	moxG	0.0002
6865	Cytochrome c-L	moxG	0.0002
4981	Iron-starvation protein PigA	pigA	0.0002
4971	Nonaheme cytochrome c	hmcA	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0002
4909	CooA protein	cooA	0.0002
4994	Hemoglobin-like protein HbO	glbO	0.0002
4935	Cytochrome c-554	cycA1	0.0002
644	Heme oxygenase 2	HMOX2	0.0002
4982	Heme oxygenase 2	pbsA2	0.0002
4942	Diheme cytochrome c napB	napB	0.0002
3116	Bacterioferritin	bfr	0.0002
4906	Bacterioferritin	bfr	0.0002
4965	Bacterioferritin	bfr	0.0002
4922	Cytochrome c, putative	SO_4144	0.0002
4764	Cytochrome P450 165C4	CYP165C4	0.0002
4937	Cytochrome oxidase subunit II	rcoxA	0.0002
4989	Cytochrome c551 peroxidase	ccp	0.0002
5222	Cytochrome c551 peroxidase	ccpA	0.0002
4961	Hemophore HasA	hasA	0.0002
4976	Apocytochrome f	petA	0.0002
6407	Apocytochrome f	petA	0.0002
4904	Cytochrome c family protein	GSU1996	0.0002
4903	Methyl-accepting chemotaxis protein	Tar4	0.0002
4999	Cytochrome P450 165B3	CYP165B3	0.0002
4960	Putative cytochrome P450-family protein	SCO7417	0.0002
4931	Cytochrome P450 167A1	CYP167A1	0.0002
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0002
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0002
4993	Hydroxylamine oxidoreductase	hao1	0.0002
4972	P450cin	cinA	0.0002
3093	Catalase HPII	katE	0.0002
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0002
4952	Catalase/peroxidase	katA	0.0002
4920	Peroxidase/catalase	katG	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
4990	PpcA	ppcA	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01101 - Capecitabine

Targets

Enzymes

Predictions