DT-Web

DB00440 - Trimethoprim


Identification
Name Trimethoprim
Accession Number DB00440 (APRD00103)
Type small molecule
Description A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 290.3177
Groups approved
Monoisotopic Weight 290.137890462
Pharmacology
Indication For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea.
Mechanism of action Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug combination also reduces the development of resistance that is seen when either drug is used alone.
Absorption Readily and almost completely absorbed in the GI tract with peak serum concentrations attained 1-4 hours after oral administration. Widely distributed to tissues and fluids including kidney, lung, seminal fluid, aqueous humour, middle ear fluid, sputum, vaginal secretions, bile, bone and CSF.
Protein binding 42-46% bound to plasma proteins
Biotransformation Hepatic metabolism to oxide and hydroxylated metabolites.
Route of elimination Ten to twenty percent of trimethoprim is metabolized, primarily in the liver; the remainder is excreted unchanged in the urine. After oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of this being unmetabolized trimethoprim. Trimethoprim also passes the placental barrier and is excreted in human milk.
Toxicity LD50=4850 (orally in mice)
Affected organisms
  • Gram negative and gram positive bacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Capecitabine The strong CYP2C9 inhibitor, Capecitabine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Capecitabine is initiated, discontinued or dose changed.
Dapsone Increased toxicity of both products
Delavirdine The strong CYP2C9 inhibitor, Delavirdine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Delavirdine is initiated, discontinued or dose changed.
Dofetilide Trimethoprim may significantly reduced the clearance of Dofetilide. Trimethoprim is a cation transport inhibitor and may interfere with renal excretion of Dofetilide. Concomitant use is contraindicated.
Floxuridine The strong CYP2C9 inhibitor, Floxuridine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Floxuridine is initiated, discontinued or dose changed.
Fluconazole The strong CYP2C9 inhibitor, Fluconazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Fluconazole is initiated, discontinued or dose changed.
Fluorouracil The strong CYP2C9 inhibitor, Fluorouracil, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Fluorouracil is initiated, discontinued or dose changed.
Flurbiprofen The strong CYP2C9 inhibitor, Flurbiprofen, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Flurbiprofen is initiated, discontinued or dose changed.
Fosphenytoin Trimethoprim increases the effect of hydantoin
Gemfibrozil The strong CYP2C9 inhibitor, Gemfibrozil, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Gemfibrozil is initiated, discontinued or dose changed.
Ibuprofen The strong CYP2C9 inhibitor, Ibuprofen, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Ibuprofen is initiated, discontinued or dose changed.
Indomethacin The strong CYP2C9 inhibitor, Indomethacine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Indomethacine is initiated, discontinued or dose changed.
Ketoconazole The strong CYP2C9 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Ketoconazole is initiated, discontinued or dose changed.
Leucovorin The efficacy of Trimethoprim may be reduced by Leucovorin (folinic acid). The antibiotic, Trimethoprim, acts by blocking bacterial folic acid metabolism. Leucovorin may reduce the efficacy of Trimethoprim by providing an alternate source of folic acid. The therapeutic effect of Trimethoprim should be closely monitored.
Mefenamic acid The strong CYP2C9 inhibitor, Mefenamic acid, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Mefenamic acid is initiated, discontinued or dose changed.
Methotrexate Trimethoprim may increase the adverse/toxic effects of Methotrexate (e.g. bone marrow suppression). Concomitant use should be avoided or closely monitored for Methotrexate toxicity.
Miconazole The strong CYP2C9 inhibitor, Miconazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Miconazole is initiated, discontinued or dose changed.
Nicardipine The strong CYP2C9 inhibitor, Nicardipine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Nicardipine is initiated, discontinued or dose changed.
Phenytoin Trimethoprim increases the effect of hydantoin
Piroxicam The strong CYP2C9 inhibitor, Piroxicam, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Piroxicam is initiated, discontinued or dose changed.
Procainamide Trimethoprim may reduce the clearance of Procainamide. Alternative treatments should be considered. If Trimethoprim is initiated or the dose is increased, monitor for increased toxicity of Procainamide (e.g. QTc intervals, EKG, serum drug concentrations). If Trimethoprim is discontinued or the dose decreased, monitor for reduced effects of Procainamide.
Rifampin Rifampin decreases the effect of trimethoprim
Sitaxentan The strong CYP2C9 inhibitor, Sitaxsentan, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Sitaxsentan is initiated, discontinued or dose changed.
Sulfadiazine The strong CYP2C9 inhibitor, Sulfadiazine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Sulfadiazine is initiated, discontinued or dose changed.
Sulfisoxazole The strong CYP2C9 inhibitor, Sulfisoxazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Sulfisoxazole is initiated, discontinued or dose changed.
Tobramycin Increased risk of nephrotoxicity
Tolbutamide The strong CYP2C9 inhibitor, Tolbutamide, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Tolbutamide is initiated, discontinued or dose changed.
Trandolapril Increased risk of hyperkalemia. Monitor serum potassium levels.
Tretinoin The moderate CYP2C8 inhibitor, Trimethoprim, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Trimethoprim is initiated, discontinued to dose changed.
Food Interactions
  • Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

Targets


Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gamarro F, Yu PL, Zhao J, Edman U, Greene PJ, Santi D: Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme. Mol Biochem Parasitol. 1995 Jun;72(1-2):11-22. - Pubmed
  • Rosowsky A, Papoulis AT, Forsch RA, Queener SF: Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim. J Med Chem. 1999 Mar 25;42(6):1007-17. - Pubmed
  • Reche P, Arrebola R, Santi DV, Gonzalez-Pacanowska D, Ruiz-Perez LM: Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain. Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):175-85. - Pubmed
  • Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE: Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. Epub 2009 Jul 10. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.618
Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DHFR
Pharmacological action no
Actions inhibitor
References
  • Laskowska E, Kuczynska-Wisnik D, Bak M, Lipinska B: Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol. 2003 Oct;47(4):286-9. - Pubmed
  • Floris-Moore MA, Amodio-Groton MI, Catalano MT: Adverse reactions to trimethoprim/sulfamethoxazole in AIDS. Ann Pharmacother. 2003 Dec;37(12):1810-3. - Pubmed
  • Rosowsky A, Fu H, Chan DC, Queener SF: Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpt eridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase. J Med Chem. 2004 May 6;47(10):2475-85. - Pubmed
  • Nahimana A, Rabodonirina M, Bille J, Francioli P, Hauser PM: Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis. Antimicrob Agents Chemother. 2004 Nov;48(11):4301-5. - Pubmed
  • Barrow EW, Bourne PC, Barrow WW: Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim. Antimicrob Agents Chemother. 2004 Dec;48(12):4643-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.106

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.364
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4581
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.282

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor,inducer
References
  • Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.332

Predictions


Id Partner name Gene Name Score
2381 Dihydrofolate reductase DFR1 1.106
2833 Dihydrofolate reductase Not Available 1.106
2931 Dihydrofolate reductase folA 1.106
3544 Dihydrofolate reductase folA 1.106
3682 Dihydrofolate reductase folA 1.106
6642 Dihydrofolate reductase folA 1.106
6756 Dihydrofolate reductase dfrA 1.106
24 Thymidylate synthase TMP1 0.618
2626 Thymidylate synthase thyA 0.618
2729 Thymidylate synthase thyA 0.618
5352 Thymidylate synthase THYA 0.618
4119 Cytochrome P450 2D6 CYP2D6 0.194
6016 Cytochrome P450 2C19 CYP2C19 0.193
4200 Cytochrome P450 1A2 CYP1A2 0.1487
4118 Cytochrome P450 3A5 CYP3A5 0.1424
6030 Cytochrome P450 2B6 CYP2B6 0.1053
6107 Cytochrome P450 3A7 CYP3A7 0.0988
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0979
6236 Trimethoprim-sensitive dihydrofolate reductase dfrB 0.0961
6013 Cytochrome P450 2E1 CYP2E1 0.0899
3639 Thymidine phosphorylase deoA 0.081
3936 Thymidine phosphorylase TYMP 0.081
587 Serum albumin ALB 0.0754
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.075
20 Prostaglandin G/H synthase 1 PTGS1 0.0692
5718 Cytochrome P450 2A6 CYP2A6 0.062
6024 Cytochrome P450 1A1 CYP1A1 0.0618
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0617
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0505
1729 Solute carrier family 22 member 6 SLC22A6 0.0476
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0458
862 Multidrug resistance-associated protein 1 ABCC1 0.0431
1124 Sepiapterin reductase SPR 0.0413
2164 Multidrug resistance-associated protein 4 ABCC4 0.0407
290 Prostaglandin G/H synthase 2 PTGS2 0.0398
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0392
6106 Cytochrome P450 2C18 CYP2C18 0.0387
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0378
1650 Heme carrier protein 1 SLC46A1 0.0376
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0354
492 Histamine H1 receptor HRH1 0.0346
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0344
871 Glucocorticoid receptor NR3C1 0.0314
3811 Cytochrome P450 19A1 CYP19A1 0.0309
4773 Deoxycytidine kinase DCK 0.0306
136 Estrogen receptor ESR1 0.0304
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0292
824 Sodium-dependent serotonin transporter SLC6A4 0.0291
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0291
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0284
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0277
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0272
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0267
1898 Cytochrome P450 1B1 CYP1B1 0.0264
3611 Cytidine deaminase cdd 0.0264
3707 Cytidine deaminase cdd 0.0264
4211 Cytidine deaminase CDA 0.0264
776 Bile salt export pump ABCB11 0.026
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0253
6145 Solute carrier family 22 member 1 SLC22A1 0.0252
2320 Thymidine kinase, cytosolic TK1 0.0251
6142 Solute carrier family 22 member 8 SLC22A8 0.0251
6143 Solute carrier family 22 member 7 SLC22A7 0.025
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0249
556 Alpha-1A adrenergic receptor ADRA1A 0.0244
502 5-hydroxytryptamine 2A receptor HTR2A 0.024
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0236
831 D(2) dopamine receptor DRD2 0.0233
4604 Liver carboxylesterase 1 CES1 0.0221
6144 Solute carrier family 22 member 2 SLC22A2 0.0214
731 HIV-1 protease HIV-1 protease 0.0212
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0209
847 Mu-type opioid receptor OPRM1 0.0208
6148 Multidrug resistance-associated protein 7 ABCC10 0.0207
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0204
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0204
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0195
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0195
467 Delta-type opioid receptor OPRD1 0.0192
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0192
617 Muscarinic acetylcholine receptor M2 CHRM2 0.018
696 Kappa-type opioid receptor OPRK1 0.0178
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0177
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0176
260 Cytochrome P450 51 ERG11 0.0172
761 Cytochrome P450 51 ERG11 0.0172
3163 Cytochrome P450 51 cyp51 0.0172
1024 Solute carrier family 22 member 11 SLC22A11 0.0171
122 P2Y purinoceptor 12 P2RY12 0.017
318 Alpha-2A adrenergic receptor ADRA2A 0.0166
766 Beta-2 adrenergic receptor ADRB2 0.0166
632 Alpha-1B adrenergic receptor ADRA1B 0.0159
118 Organic cation/carnitine transporter 2 SLC22A5 0.0159
6182 Cytochrome P450 2J2 CYP2J2 0.0159
70 Type-1 angiotensin II receptor AGTR1 0.0155
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0154
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0154
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0153
320 5-hydroxytryptamine 1A receptor HTR1A 0.0152
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0151
23 D(1A) dopamine receptor DRD1 0.0147
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0147
891 Dihydropteroate synthase folP 0.0146
5359 Dihydropteroate synthase folP 0.0146
7175 Dihydropteroate synthase sulI 0.0146
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0145
3923 Cholinesterase BCHE 0.0145
193 Beta-1 adrenergic receptor ADRB1 0.0145
590 5-hydroxytryptamine 2C receptor HTR2C 0.0142
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.014
614 Progesterone receptor PGR 0.0137
6136 Multidrug resistance-associated protein 5 ABCC5 0.0136
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0136
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0136
341 5-hydroxytryptamine 3 receptor HTR3A 0.0134
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0134
817 DNA topoisomerase 2-alpha TOP2A 0.0133
6031 Cytochrome P450 3A43 CYP3A43 0.0133
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0132
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0131
2567 Thymidylate synthase thyX thyX 0.0128
146 Androgen receptor AR 0.0128
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0127
465 Calmodulin CALM1 0.0126
713 Sodium-dependent dopamine transporter SLC6A3 0.0126
468 Cytochrome P450 4A11 CYP4A11 0.0126
3941 Amine oxidase [flavin-containing] A MAOA 0.0126
789 Alpha-1D adrenergic receptor ADRA1D 0.0122
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0121
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0119
6147 Solute carrier family 22 member 3 SLC22A3 0.0118
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
844 Epidermal growth factor receptor EGFR 0.0118
6141 Sodium/bile acid cotransporter SLC10A1 0.0118
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0115
2555 Pol polyprotein pol 0.0114
3242 Pol polyprotein gag-pol 0.0114
3471 Pol polyprotein gag-pro-pol 0.0114
5256 Pol polyprotein pol 0.0114
6469 Pol polyprotein gag-pol 0.0114
6565 Pol polyprotein Not Available 0.0114
702 UMP-CMP kinase CMPK1 0.0113
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
504 Mast/stem cell growth factor receptor KIT 0.0111
6137 Multidrug resistance-associated protein 6 ABCC6 0.0111
811 Translocator protein TSPO 0.011
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.011
869 Estrogen receptor beta ESR2 0.011
4120 NADPH--cytochrome P450 reductase POR 0.0107
29 Tubulin beta-1 chain TUBB1 0.0107
885 5-hydroxytryptamine 1B receptor HTR1B 0.0105
3939 Amine oxidase [flavin-containing] B MAOB 0.0104
952 Dipeptidyl peptidase 4 DPP4 0.0104
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0103
738 Monocarboxylate transporter 1 SLC16A1 0.01
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0099
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0099
2251 Thymidylate kinase tmk 0.0098
2254 Thymidylate kinase DTYMK 0.0098
3522 Thymidylate kinase tmk 0.0098
380 Cytochrome P450 17A1 CYP17A1 0.0098
725 5-hydroxytryptamine 1D receptor HTR1D 0.0097
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0096
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0096
833 Organic cation/carnitine transporter 1 SLC22A4 0.0096
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0096
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0095
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0094
6171 Solute carrier family 28 member 3 SLC28A3 0.0094
638 D(3) dopamine receptor DRD3 0.0094
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0093
407 Vascular endothelial growth factor receptor 2 KDR 0.0093
436 5-hydroxytryptamine 2B receptor HTR2B 0.0092
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
161 Tubulin beta chain TUBB 0.0091
312 Tubulin beta chain TUB2 0.0091
629 Alpha-2B adrenergic receptor ADRA2B 0.009
6020 Aldehyde oxidase AOX1 0.009
756 Sex hormone-binding globulin SHBG 0.009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0089
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6102 Arylamine N-acetyltransferase 2 NAT2 0.0088
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0088
818 50S ribosomal protein L10 rplJ 0.0085
509 Thymidine kinase TK 0.0085
570 Thymidine kinase TK 0.0085
2559 Thymidine kinase TK 0.0085
3430 Thymidine kinase tdk 0.0085
3518 Thymidine kinase TK 0.0085
5301 Thymidine kinase tdk 0.0085
5771 Thymidine kinase ORF36 0.0085
7009 Thymidine kinase ORF36 0.0085
474 Acetylcholinesterase ACHE 0.0084
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0084
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
777 Tumor necrosis factor TNF 0.0083
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0083
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0082
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0082
737 Mineralocorticoid receptor NR3C2 0.0082
1192 Sulfotransferase 1A1 SULT1A1 0.0082
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0082
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0079
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0079
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0079
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0079
124 Histamine H2 receptor HRH2 0.0078
6085 Fatty acid-binding protein, intestinal FABP2 0.0078
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0077
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
4226 Uridine phosphorylase 2 UPP2 0.0077
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0077
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0076
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0075
26 Vascular endothelial growth factor receptor 3 FLT4 0.0075
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0075
1541 Metalloproteinase mmp20 0.0074
4225 Uridine phosphorylase 1 UPP1 0.0074
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0074
32 Vascular endothelial growth factor receptor 1 FLT1 0.0072
378 Alpha-2C adrenergic receptor ADRA2C 0.0071
228 Beta platelet-derived growth factor receptor PDGFRB 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
295 Carbonic anhydrase 1 CA1 0.0071
49 Endothelin B receptor EDNRB 0.0069
373 Transthyretin TTR 0.0069
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0069
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0069
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0069
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0069
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0069
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0069
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0069
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0068
5818 Folate receptor alpha FOLR1 0.0067
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
6138 Multidrug resistance protein 3 ABCB4 0.0067
427 Substance-P receptor TACR1 0.0067
3810 Catechol O-methyltransferase COMT 0.0066
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
88 Retinoic acid receptor RXR-beta RXRB 0.0065
413 Amidophosphoribosyltransferase PPAT 0.0064
2515 Amidophosphoribosyltransferase purF 0.0064
3714 Amidophosphoribosyltransferase purF 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
716 5-hydroxytryptamine 7 receptor HTR7 0.0063
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
133 Dihydropterate synthase sulI 0.0063
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
1010 Cytochrome P450 51A1 CYP51A1 0.0061
4203 Histamine N-methyltransferase HNMT 0.0061
275 Arachidonate 5-lipoxygenase ALOX5 0.0061
4534 Cytohesin-2 CYTH2 0.0061
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.006
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0059
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0059
293 Gamma-glutamyl hydrolase GGH 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0057
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
1656 CYP2B protein CYP2B 0.0056
432 D(4) dopamine receptor DRD4 0.0056
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0056
68 Cannabinoid receptor 1 CNR1 0.0055
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0055
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0055
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0055
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0055
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0055
814 Ryanodine receptor 1 RYR1 0.0055
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0054
1629 Transcription factor AP-1 JUN 0.0054
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0054
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
1757 Myeloperoxidase MPO 0.0054
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
1852 Microtubule-associated protein 2 MAP2 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
3947 Xanthine dehydrogenase/oxidase XDH 0.0053
2592 Beta-galactosidase lacZ 0.0053
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0052
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0052
2539 Tubulin alpha-1 chain TUBA4A 0.0051
6220 Aryl hydrocarbon receptor AHR 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
357 Carbonic anhydrase 2 CA2 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
1275 Estrogen sulfotransferase SULT1E1 0.005
315 Arginase-1 ARG1 0.005
6014 Cytochrome P450 2A13 CYP2A13 0.0049
1178 Adenosine A2a receptor ADORA2A 0.0049
856 Vitamin D3 receptor VDR 0.0049
1050 Bile salt sulfotransferase SULT2A1 0.0048
780 Retinoic acid receptor RXR-gamma RXRG 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0047
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0047
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1648 Elastin ELN 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
319 Opioid receptor, sigma 1 OPRS1 0.0046
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0045
54 Prothrombin F2 0.0045
239 Coagulation factor X F10 0.0045
527 Prostacyclin receptor PTGIR 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
921 Glutamate receptor 2 GRIA2 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
4122 Histone deacetylase 2 HDAC2 0.0041
16 Adenosine A1 receptor ADORA1 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
284 DNA-directed RNA polymerase beta chain rpoB 0.0041
5773 DNA-directed RNA polymerase beta chain rpoB 0.0041
2159 Quinone oxidoreductase CRYZ 0.004
3809 Estrogen-related receptor gamma ESRRG 0.004
165 FL cytokine receptor FLT3 0.004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.004
273 Apoptosis regulator Bcl-2 BCL2 0.004
162 Retinoic acid receptor gamma-1 RARG 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.004
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.004
1129 C-C chemokine receptor type 5 CCR5 0.0039
1618 High affinity nerve growth factor receptor NTRK1 0.0039
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
528 5-hydroxytryptamine 1E receptor HTR1E 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0038
823 Fibroblast growth factor receptor 2 FGFR2 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
469 Annexin A1 ANXA1 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
6043 Putative G-protein coupled receptor 44 GPR44 0.0037
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
5787 Angiopoietin-1 receptor TEK 0.0035
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0035
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
518 Peroxidase/catalase T katG 0.0035
939 50S ribosomal protein L3 rplC 0.0035
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
904 Glutathione S-transferase P GSTP1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
5880 Thrombopoietin receptor MPL 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
1256 5-hydroxytryptamine 6 receptor HTR6 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
84 Nuclear receptor 0B1 NR0B1 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
705 Glutamate receptor 1 GRIA1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0028
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0028
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1630 Integrin beta-2 ITGB2 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
976 Platelet glycoprotein IX GP9 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
444 Alcohol dehydrogenase 1B ADH1B 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
605 Fumarate reductase flavoprotein subunit frdA 0.0027
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0027
3673 Fumarate reductase flavoprotein subunit fccA 0.0027
4912 Fumarate reductase flavoprotein subunit ifcA 0.0027
6549 Fumarate reductase flavoprotein subunit frdA 0.0027
6146 High affinity copper uptake protein 1 SLC31A1 0.0026
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
511 5-hydroxytryptamine 1F receptor HTR1F 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
936 Ephrin type-A receptor 2 EPHA2 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
164 Histamine H4 receptor HRH4 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
174 Sigma 1-type opioid receptor SIGMAR1 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6044 Serum paraoxonase/lactonase 3 PON3 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1992 Vitamin D-binding protein GC 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
4192 DNA topoisomerase 2-beta TOP2B 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
489 Monocarboxylate transporter 2 SLC16A7 0.0021
7 Nitric oxide synthase, inducible NOS2 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
3957 Adenosine deaminase ADA 0.0021
572 Integrin alpha-L ITGAL 0.0021
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0021
5798 Mitogen-activated protein kinase 11 MAPK11 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
6432 Transporter snf 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.002
6459 Glycodelin PAEP 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
569 Retinal dehydrogenase 2 ALDH1A2 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0019
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0019
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0019
666 NADP-dependent malic enzyme ME1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
2021 Thrombomodulin THBD 0.0019
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0018
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0018
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0018
5332 MtdA bifunctional protein mtdA 0.0018
4403 Protein iolS iolS 0.0018
5322 Oxidoreductase ydhF ydhF 0.0018
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0018
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0018
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0018
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0018
5330 General stress protein 69 yhdN 0.0018
3778 NAD(P) transhydrogenase subunit beta pntB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6218 Pannexin-1 PANX1 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
751 Potassium channel subfamily K member 6 KCNK6 0.0018
2207 Rhodopsin RHO 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
1374 Natriuretic peptides B NPPB 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
3937 Fatty-acid amide hydrolase FAAH 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
563 Thyroid peroxidase TPO 0.0016
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0016
4582 Putative pteridine reductase 2 ptr2 0.0016
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0016
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0016
5073 Ferredoxin--NADP reductase petH 0.0016
5076 Ferredoxin--NADP reductase fpr 0.0016
5119 Ferredoxin--NADP reductase petH 0.0016
5121 Ferredoxin--NADP reductase fpr 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
989 L-xylulose reductase DCXR 0.0016
3446 NADP-dependent alcohol dehydrogenase adh 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
2636 Shikimate dehydrogenase aroE 0.0016
3515 Shikimate dehydrogenase aroE 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0016
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0016
2286 Isocitrate dehydrogenase [NADP] icd 0.0016
2302 Isocitrate dehydrogenase [NADP] icd 0.0016
2771 Isocitrate dehydrogenase [NADP] icd 0.0016
173 Toll-like receptor 7 TLR7 0.0016
654 Flavin reductase BLVRB 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
6755 Poliovirus receptor PVR 0.0015
6677 Myelin P2 protein PMP2 0.0015
76 Nitric-oxide synthase, brain NOS1 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0015
6297 Prostaglandin reductase 1 PTGR1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4531 Putative ketoacyl reductase actIII 0.0015
3062 Aspartate-semialdehyde dehydrogenase asd 0.0014
1341 Histamine H3 receptor HRH3 0.0014
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
251 Alcohol dehydrogenase 1A ADH1A 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
2675 Pteridine reductase 1 PTR1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
1039 Histone deacetylase 9 HDAC9 0.0013
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0013
517 Alcohol dehydrogenase 1C ADH1C 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
822 Aldose reductase AKR1B1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
3221 Cytochrome c4 cc4 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
33 Cystine/glutamate transporter SLC7A11 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
6859 Protein S100-A4 S100A4 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
1867 Major prion protein PRNP 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
1507 Cytochrome c CYCS 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
816 Biliverdin reductase A BLVRA 0.0006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0006
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0006
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0005
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
328 Sorbitol dehydrogenase SORD 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0005
597 Dihydropteridine reductase QDPR 0.0005
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0005
396 Alcohol dehydrogenase 4 ADH4 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0005
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0005
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0005
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0005
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0005
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0005
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0005
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0005
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0005
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0005
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0005
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0005
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0005
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0005
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0005
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0005
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0005
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0005
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0005
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0005
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0005
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0005
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0005
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0005
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0005
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0005
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0005
107 C-4 methylsterol oxidase SC4MOL 0.0005
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0005
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0005
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0005
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0005
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0005
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0005
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0005
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0005
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0005
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0005
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0005
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0005
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0005
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0005
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0005
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0005
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0005
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0005
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0005
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0005
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0005
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0005
3726 D-3-phosphoglycerate dehydrogenase serA 0.0005
4291 D-3-phosphoglycerate dehydrogenase serA 0.0005
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0005
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0005
729 GDP-L-fucose synthetase TSTA3 0.0005
3463 GDP-L-fucose synthetase fcl 0.0005
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0005
167 L-lactate dehydrogenase C chain LDHC 0.0005
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0005
206 3-keto-steroid reductase HSD17B7 0.0005
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0005
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0005
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0005
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0005
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0005
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0005
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0005
643 Peroxisomal bifunctional enzyme EHHADH 0.0005
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0005
34 7-dehydrocholesterol reductase DHCR7 0.0005
711 UDP-glucose 6-dehydrogenase UGDH 0.0005
3672 UDP-glucose 6-dehydrogenase hasB 0.0005
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0005
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0005
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0005
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
6026 Alcohol dehydrogenase 6 ADH6 0.0004
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0004
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0004
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0004
626 Cysteine dioxygenase type 1 CDO1 0.0004
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0004
627 11-cis retinol dehydrogenase RDH5 0.0004
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
714 Glutathione reductase, mitochondrial GSR 0.0004
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
279 Tyrosinase TYR 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
4920 Peroxidase/catalase katG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
693 Hemoglobin subunit beta HBB 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑