DT-Web: DB00563

Identification

Name

Methotrexate

Accession Number

DB00563 (APRD00353)

Type

small molecule

Description

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

454.4393

Groups

approved

Monoisotopic Weight

454.171315854

Pharmacology

Indication

Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin's lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis.

Mechanism of action

Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Absorption

Oral absorption is dose dependent in adults and leukemic pediatric patients. In adults, peak serum levels are reached within one to two hours. At doses of 30 mg/m^2 or less, methotrexate is generally well absorbed with a mean bioavailability of 60%. At doses greater than 80 mg/m^2, the absorption of the doses is significantly less due to a saturation effect.

Protein binding

50% bound to protein, primarily to albumin

Biotransformation

Methotrexate undergoes hepatic and intracellular metabolism to polyglutamated forms which can be converted back to methotrexate by hydroxylase enzymes. These polyglutamates act as inhibitors of dihydrofolate reductase and thymidylate synthetase. A small amount of metabolism to 7-hydroxymethotrexate may occur at doses commonly prescribed. Furthermore, intestinal flora partially metabolizes methotrexate after oral administration.

Route of elimination

Renal excretion is the primary route of elimination and is dependent upon dosage and route of administration. IV administration, 80% to 90% of the administered dose is excreted unchanged in the urine within 24 hours. There is limited biliary excretion amounting to 10% or less of the administered dose.

Toxicity

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD₅₀=43mg/kg(orally in rat).

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetylsalicylic acid	Acetylsalicylic acid increases the effect and toxicity of methotrexate.
Acitretin	Acitretin/etretinate increases the effect and toxicity of methotrexate
Amoxicillin	The penicillin increases the effect and toxicity of methotrexate
Ampicillin	The penicillin increases the effect and toxicity of methotrexate
Bacampicillin	The penicillin increases the effect and toxicity of methotrexate
Bismuth Subsalicylate	The salicylate, bismuth subsalicylate, increases the effect and toxicity of methotrexate.
Carbenicillin	The penicillin increases the effect and toxicity of methotrexate
Cholestyramine	Decreased levels of methotrexate
Ciprofloxacin	Ciprofloxacine may decrease the metabolism of methotrexate. Monitor for changes adverse effects of methotrexate if ciprofloxacin is initiated.
Cisplatin	Cisplatin increases methotrexate toxicity
Clavulanate	The penicillin increases the effect and toxicity of methotrexate
Cloxacillin	The penicillin increases the effect and toxicity of methotrexate
Cyclosporine	Cyclosporine may increase the effect and toxicity of methotrexate.
Diclofenac	The NSAID, diclofenac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Dicloxacillin	The penicillin increases the effect and toxicity of methotrexate
Diflunisal	The NSAID, diflunisal, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Digoxin	The antineoplasic agent decreases the effect of digoxin
Doxycycline	The tetracycline, doxycycline, may increase methotrexate toxicity.
Eltrombopag	Increases levels of Methotrexate via metabolism decrease. OATP transporter protein inhibition.
Ethotoin	The antineoplasic agent decreases the effect of hydantoin
Etodolac	The NSAID, etodolac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Etretinate	Acitretin/etretinate increases the effect and toxicity of methotrexate
Fenoprofen	The NSAID, fenoprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Flucloxacillin	The penicillin increases the effect and toxicity of methotrexate
Flurbiprofen	The NSAID, flurbiprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Fosphenytoin	The antineoplasic agent decreases the effect of hydantoin
Hydroxychloroquine	Hydroxychloroquine increases the effect and toxicity of methotrexate
Ibuprofen	The NSAID, ibuprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Indomethacin	The NSAID, indomethacin, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Ketoprofen	The NSAID, ketoprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Ketorolac	The NSAID, ketorolac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Magnesium salicylate	The salicylate, magnesium salicylate, increases the effect and toxicity of methotrexate.
Meclofenamic acid	The NSAID, meclofenamic acid, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Mefenamic acid	The NSAID, mefenamic acid, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Mephenytoin	The antineoplasic agent decreases the effect of hydantoin
Methicillin Acyl-Serine	The penicillin increases the effect and toxicity of methotrexate
Mezlocillin	The penicillin increases the effect and toxicity of methotrexate
Nabumetone	The NSAID, nabumetone, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Nafcillin	The penicillin increases the effect and toxicity of methotrexate
Naproxen	The NSAID, naproxen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Omeprazole	Omeprazole increases the levels of methotrexate
Oxaprozin	The NSAID, oxaprozin, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Penicillin G	The penicillin increases the effect and toxicity of methotrexate
Penicillin V	The penicillin increases the effect and toxicity of methotrexate
Phenylbutazone	The NSAID, phenylbutazone, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Phenytoin	The antineoplasic agent decreases the effect of hydantoin
Piperacillin	The penicillin increases the effect and toxicity of methotrexate
Piroxicam	The NSAID, piroxicam, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pivampicillin	The penicillin increases the effect and toxicity of methotrexate
Probenecid	Probenecid increases the effect and toxicity of methotrexate
Procarbazine	Increased nephrotoxicity with this combination
Rilonacept	Rilonacept and methotrexate both increase immunosuppressive effects; combination may increase risk of myelosuppression.
Rofecoxib	Rofecoxib increases the levels of methotrexate
Salicylate-sodium	The salicylate, salicylate-sodium, increases the effect and toxicity of methotrexate.
Salsalate	The salicylate, salsalate, increases the effect and toxicity of methotrexate.
Sulfacytine	The sulfamide increases the toxicity of methotrexate
Sulfadiazine	The sulfamide increases the toxicity of methotrexate
Sulfadimethoxine	The sulfamide increases the toxicity of methotrexate
Sulfadoxine	The sulfamide increases the toxicity of methotrexate
Sulfamerazine	The sulfamide increases the toxicity of methotrexate
Sulfamethazine	The sulfamide increases the toxicity of methotrexate
Sulfamethizole	The sulfamide increases the toxicity of methotrexate
Sulfamethoxazole	The sulfamide increases the toxicity of methotrexate
Sulfapyridine	The sulfamide increases the toxicity of methotrexate
Sulfathiazole	The sulfamide increases the toxicity of methotrexate
Sulfisoxazole	The sulfamide increases the toxicity of methotrexate
Sulindac	The NSAID, sulindac, may decrease the clearance methotrexate. Consider alternate therapy, especially in patients receiving high antineoplastic doses of methotrexate. Otherwise, monitor for hematologic and renal toxicities.
Tenoxicam	Tenoxicam may increase the serum concentration of Methotrexate by reducing renal tubular secretion of Methotrexate. Monitor for changes in Methotrexate therapeutic and adverse effects if Tenoxicam is initiated, discontinued or dose changed.
Tetracycline	Tetracycline may increase methotrexate toxicity.
Tiaprofenic acid	Tiaprofenic acid may decrease renal excretion of methotrexate. Consider alternate therapy or monitor for methotrexate toxicity.
Ticarcillin	The penicillin increases the effect and toxicity of methotrexate
Tolmetin	Tolmetin may decrease the renal excretion of Methotrexate. Alternate therapy should be considered. Otherwise, monitor for hemotologic and renal toxicities.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trimethoprim	Trimethoprim may increase the adverse/toxic effects of Methotrexate (e.g. bone marrow suppression). Concomitant use should be avoided or closely monitored for Methotrexate toxicity.
Trisalicylate-choline	The salicylate, trisalicylate-choline, increases the effect and toxicity of methotrexate.

Food Interactions

Milk appears to reduce its absorption.
Take without regard to meals. Limit caffeine intake.

Dihydrofolate reductase
Name	Dihydrofolate reductase
Gene Name	DHFR
Pharmacological action	yes
Actions	inhibitor
References	Al-Rashood ST, Aboldahab IA, Nagi MN, Abouzeid LA, Abdel-Aziz AA, Abdel-Hamide SG, Youssef KM, Al-Obaid AM, El-Subbagh HI: Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs. Bioorg Med Chem. 2006 Dec 15;14(24):8608-21. Epub 2006 Sep 12. - Pubmed Assaraf YG: Molecular basis of antifolate resistance. Cancer Metastasis Rev. 2007 Mar;26(1):153-81. - Pubmed Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C: Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18493-8. Epub 2006 Nov 27. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Totani K, Matsuo I, Ihara Y, Ito Y: High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates. Bioorg Med Chem. 2006 Aug 1;14(15):5220-9. Epub 2006 May 2. - Pubmed Uga H, Kuramori C, Ohta A, Tsuboi Y, Tanaka H, Hatakeyama M, Yamaguchi Y, Takahashi T, Kizaki M, Handa H: A new mechanism of methotrexate action revealed by target screening with affinity beads. Mol Pharmacol. 2006 Nov;70(5):1832-9. Epub 2006 Aug 25. - Pubmed
DTHybrid score	1.3841

Methylenetetrahydrofolate reductase
Name	Methylenetetrahydrofolate reductase
Gene Name	MTHFR
Actions	substrate
References	- Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed Kremer JM: Methotrexate pharmacogenomics. Ann Rheum Dis. 2006 Sep;65(9):1121-3. - Pubmed
DTHybrid score	0.3551
Aldehyde oxidase
Name	Aldehyde oxidase
Gene Name	AOX1
Actions	substrate
References	- Zientek M, Jiang Y, Youdim K, Obach RS: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010 Aug;38(8):1322-7. Epub 2010 May 5. - Pubmed Baggott JE, Morgan SL: Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. Arthritis Rheum. 2009 Aug;60(8):2257-61. - Pubmed Jordan CG, Rashidi MR, Laljee H, Clarke SE, Brown JE, Beedham C: Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol. 1999 Apr;51(4):411-8. - Pubmed
DTHybrid score	0.3494
6-phosphogluconate dehydrogenase, decarboxylating
Name	6-phosphogluconate dehydrogenase, decarboxylating
Gene Name	PGD
Actions	inhibitor
References	Akkemik E, Budak H, Ciftci M: Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem. 2010 Mar 17. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.6181
Folylpolyglutamate synthase, mitochondrial
Name	Folylpolyglutamate synthase, mitochondrial
Gene Name	FPGS
Actions	substrate
References	Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed
DTHybrid score	0.5817
Gamma-glutamyl hydrolase
Name	Gamma-glutamyl hydrolase
Gene Name	GGH
Actions	substrate
References	Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed
DTHybrid score	0.3509
Dihydrofolate reductase
Name	Dihydrofolate reductase
Gene Name	DHFR
Actions	substrate
References	Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed
DTHybrid score	1.3841
Thymidylate synthase
Name	Thymidylate synthase
Gene Name	TYMS
Actions	substrate
References	Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed
DTHybrid score	0.959
Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Name	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name	ATIC
Actions	inhibitor
References	Hider SL, Bruce IN, Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. Epub 2007 Jun 24. - Pubmed
DTHybrid score	0.9524

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	substrate,inhibitor
References	Akita H, Suzuki H, Hirohashi T, Takikawa H, Sugiyama Y: Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm Res. 2002 Jan;19(1):34-41. - Pubmed Oleschuk CJ, Deeley RG, Cole SP: Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G280-9. Epub 2002 Oct 9. - Pubmed Hirohashi T, Suzuki H, Sugiyama Y: Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem. 1999 May 21;274(21):15181-5. - Pubmed Zeng H, Liu G, Rea PA, Kruh GD: Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 2000 Sep 1;60(17):4779-84. - Pubmed Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed Paumi CM, Wright M, Townsend AJ, Morrow CS: Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37. - Pubmed Li T, Ito K, Horie T: Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G602-10. - Pubmed Zehnpfennig B, Urbatsch IL, Galla HJ: Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30. - Pubmed
DTHybrid score	0.4526
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate,inhibitor
References	Chen ZS, Lee K, Kruh GD: Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem. 2001 Sep 7;276(36):33747-54. Epub 2001 Jul 10. - Pubmed Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed Bai J, Lai L, Yeo HC, Goh BC, Tan TM: Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. - Pubmed van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002 Mar;13(3):595-603. - Pubmed
DTHybrid score	0.5743
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed Paumi CM, Wright M, Townsend AJ, Morrow CS: Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37. - Pubmed
DTHybrid score	0.4899
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate,inhibitor
References	Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed Uwai Y, Iwamoto K: Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. - Pubmed
DTHybrid score	0.8212
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score	0.2857
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed Uwai Y, Iwamoto K: Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. - Pubmed
DTHybrid score	0.7456
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate,inhibitor
References	Han YH, Kato Y, Haramura M, Ohta M, Matsuoka H, Sugiyama Y: Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2). Pharm Res. 2001 May;18(5):579-86. - Pubmed Masuda M, I'izuka Y, Yamazaki M, Nishigaki R, Kato Y, Ni'inuma K, Suzuki H, Sugiyama Y: Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res. 1997 Aug 15;57(16):3506-10. - Pubmed Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, Noordhuis P, Scheper RJ, Borst P, Pinedo HM, Jansen G: Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999 Jun 1;59(11):2532-5. - Pubmed Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed Chen C, Scott D, Hanson E, Franco J, Berryman E, Volberg M, Liu X: Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. Pharm Res. 2003 Jan;20(1):31-7. - Pubmed
DTHybrid score	0.6019
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Norris MD, De Graaf D, Haber M, Kavallaris M, Madafiglio J, Gilbert J, Kwan E, Stewart BW, Mechetner EB, Gudkov AV, Roninson IB: Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int J Cancer. 1996 Mar 1;65(5):613-9. - Pubmed
DTHybrid score	0.7431
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate
References	Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, Hagenbuch B: Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95. - Pubmed
DTHybrid score	0.5819
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	substrate
References	Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. - Pubmed
DTHybrid score	0.3922
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions	substrate
References	Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score	0.3731
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. - Pubmed
DTHybrid score	0.5094
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	substrate
References	Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score	0.5063
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	substrate
References	Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score	0.3873
Solute carrier organic anion transporter family member 3A1
Name	Solute carrier organic anion transporter family member 3A1
Gene Name	SLCO3A1
Actions	substrate
References	Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T: Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. - Pubmed
DTHybrid score	0.3223
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. Epub 2003 Apr 7. - Pubmed Breedveld P, Zelcer N, Pluim D, Sonmezer O, Tibben MM, Beijnen JH, Schinkel AH, van Tellingen O, Borst P, Schellens JH: Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11. - Pubmed Mitomo H, Kato R, Ito A, Kasamatsu S, Ikegami Y, Kii I, Kudo A, Kobatake E, Sumino Y, Ishikawa T: A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport. Biochem J. 2003 Aug 1;373(Pt 3):767-74. - Pubmed Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, Kruh GD: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. - Pubmed Volk EL, Schneider E: Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43. - Pubmed Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. Epub 2008 Nov 17. - Pubmed Hou YX, Li CZ, Palaniyandi K, Magtibay PM, Homolya L, Sarkadi B, Chang XB: Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport. Biochemistry. 2009 Sep 29;48(38):9122-31. - Pubmed Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009 Jun 28;279(1):74-83. Epub 2009 Feb 18. - Pubmed
DTHybrid score	0.5743
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Sun W, Wu RR, van Poelje PD, Erion MD: Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun. 2001 May 4;283(2):417-22. - Pubmed Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score	0.4809
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate
References	Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. - Pubmed van de Steeg E, van der Kruijssen CM, Wagenaar E, Burggraaff JE, Mesman E, Kenworthy KE, Schinkel AH: Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab Dispos. 2009 Feb;37(2):277-81. Epub 2008 Nov 20. - Pubmed
DTHybrid score	0.6481
Heme carrier protein 1
Name	Heme carrier protein 1
Gene Name	SLC46A1
Actions	substrate,inhibitor
References	Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H: Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther. 2007 Aug;322(2):469-76. Epub 2007 May 2. - Pubmed
DTHybrid score	0.5809
Solute carrier organic anion transporter family member 4C1
Name	Solute carrier organic anion transporter family member 4C1
Gene Name	SLCO4C1
Actions	Not Available
References	Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score	0.3535
Folate transporter 1
Name	Folate transporter 1
Gene Name	Not Available
Actions	substrate
References	Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID: Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006 Dec 1;127(5):917-28. - Pubmed
DTHybrid score	Not Available
Folate receptor alpha
Name	Folate receptor alpha
Gene Name	FOLR1
Actions	substrate
References	Sharma S, Das M, Kumar A, Marwaha V, Shankar S, Aneja R, Grover R, Arya V, Dhir V, Gupta R, Kumar U, Juyal RC, B K T: Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians. Pharmacogenet Genomics. 2008 Dec;18(12):1041-9. - Pubmed
DTHybrid score	0.2165

Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions
References	Not Available
DTHybrid score	0.4526
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.5743
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.4899
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.8212
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions
References	Not Available
DTHybrid score	0.2857
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.7456
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.6019
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.7431
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.5819
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions
References	Not Available
DTHybrid score	0.3922
ATP-binding cassette transporter sub-family C member 11
Name	ATP-binding cassette transporter sub-family C member 11
Gene Name	ABCC11
Actions
References	Not Available
DTHybrid score	0.3731
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions
References	Not Available
DTHybrid score	0.5094
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.5063
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions
References	Not Available
DTHybrid score	0.3873
Solute carrier organic anion transporter family member 3A1
Name	Solute carrier organic anion transporter family member 3A1
Gene Name	SLCO3A1
Actions
References	Not Available
DTHybrid score	0.3223
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.5743
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.4809
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.6481
Heme carrier protein 1
Name	Heme carrier protein 1
Gene Name	SLC46A1
Actions
References	Not Available
DTHybrid score	0.5809
Solute carrier organic anion transporter family member 4C1
Name	Solute carrier organic anion transporter family member 4C1
Gene Name	SLCO4C1
Actions
References	Not Available
DTHybrid score	0.3535
Folate transporter 1
Name	Folate transporter 1
Gene Name	Not Available
Actions
References	Not Available
DTHybrid score	Not Available
Folate receptor alpha
Name	Folate receptor alpha
Gene Name	FOLR1
Actions
References	Not Available
DTHybrid score	0.2165

Id	Partner name	Gene Name	Score
2381	Dihydrofolate reductase	DFR1	1.3841
2833	Dihydrofolate reductase	Not Available	1.3841
2931	Dihydrofolate reductase	folA	1.3841
3544	Dihydrofolate reductase	folA	1.3841
3682	Dihydrofolate reductase	folA	1.3841
6642	Dihydrofolate reductase	folA	1.3841
6756	Dihydrofolate reductase	dfrA	1.3841
24	Thymidylate synthase	TMP1	0.959
2626	Thymidylate synthase	thyA	0.959
2729	Thymidylate synthase	thyA	0.959
5352	Thymidylate synthase	THYA	0.959
4512	Cytochrome P450 3A4	CYP3A4	0.5167
4757	Cytochrome P450 2C9	CYP2C9	0.3537
4924	Cytochrome P450 2C8	CYP2C8	0.3376
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.2861
4118	Cytochrome P450 3A5	CYP3A5	0.2724
4200	Cytochrome P450 1A2	CYP1A2	0.2531
6016	Cytochrome P450 2C19	CYP2C19	0.2362
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.2241
776	Bile salt export pump	ABCB11	0.2035
6141	Sodium/bile acid cotransporter	SLC10A1	0.1972
4119	Cytochrome P450 2D6	CYP2D6	0.1842
20	Prostaglandin G/H synthase 1	PTGS1	0.1799
6107	Cytochrome P450 3A7	CYP3A7	0.1795
299	Folate receptor beta	FOLR2	0.1779
718	Folate receptor gamma	FOLR3	0.1778
804	Mitochondrial folate transporter/carrier	SLC25A32	0.1778
6136	Multidrug resistance-associated protein 5	ABCC5	0.1747
290	Prostaglandin G/H synthase 2	PTGS2	0.174
6145	Solute carrier family 22 member 1	SLC22A1	0.1672
6013	Cytochrome P450 2E1	CYP2E1	0.162
118	Organic cation/carnitine transporter 2	SLC22A5	0.153
6024	Cytochrome P450 1A1	CYP1A1	0.142
6144	Solute carrier family 22 member 2	SLC22A2	0.1394
489	Monocarboxylate transporter 2	SLC16A7	0.1361
6030	Cytochrome P450 2B6	CYP2B6	0.1343
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1343
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.1244
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1213
6167	Organic solute transporter subunit beta	OSTB	0.1174
6166	Organic solute transporter subunit alpha	OSTA	0.1173
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.1151
758	Thyroid hormone receptor alpha	THRA	0.1128
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.1125
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.1085
3639	Thymidine phosphorylase	deoA	0.1057
3936	Thymidine phosphorylase	TYMP	0.1057
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1031
6137	Multidrug resistance-associated protein 6	ABCC6	0.098
33	Cystine/glutamate transporter	SLC7A11	0.0968
6236	Trimethoprim-sensitive dihydrofolate reductase	dfrB	0.0961
346	Thyroid hormone receptor beta-1	THRB	0.096
3947	Xanthine dehydrogenase/oxidase	XDH	0.0957
4773	Deoxycytidine kinase	DCK	0.0924
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0889
3587	Gastrotropin	FABP6	0.0887
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.087
500	Monocarboxylate transporter 4	SLC16A3	0.0856
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0848
594	Thyroxine-binding globulin	SERPINA7	0.0839
1898	Cytochrome P450 1B1	CYP1B1	0.0836
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0833
6149	Solute carrier family 22 member 10	SLC22A10	0.0826
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0778
5718	Cytochrome P450 2A6	CYP2A6	0.0748
833	Organic cation/carnitine transporter 1	SLC22A4	0.0725
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0717
136	Estrogen receptor	ESR1	0.0715
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0713
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0683
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0683
338	DNA polymerase	UL30	0.068
379	DNA polymerase	UL54	0.068
697	DNA polymerase	ORF28	0.068
2482	DNA polymerase	43	0.068
4104	DNA polymerase	BALF5	0.068
817	DNA topoisomerase 2-alpha	TOP2A	0.0672
373	Transthyretin	TTR	0.0671
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0653
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0648
6147	Solute carrier family 22 member 3	SLC22A3	0.0639
275	Arachidonate 5-lipoxygenase	ALOX5	0.0636
4604	Liver carboxylesterase 1	CES1	0.0632
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0589
70	Type-1 angiotensin II receptor	AGTR1	0.0589
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0586
2621	Thermoresistant gluconokinase	gntK	0.0571
244	Angiotensin-converting enzyme	ACE	0.0557
3811	Cytochrome P450 19A1	CYP19A1	0.0544
723	Cytosolic phospholipase A2	PLA2G4A	0.0532
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0518
5626	Nucleoside diphosphate kinase B	NME2	0.0511
1792	Tissue-type plasminogen activator	PLAT	0.051
6151	Monocarboxylate transporter 10	SLC16A10	0.0509
199	Monocarboxylate transporter 8	SLC16A2	0.0491
766	Beta-2 adrenergic receptor	ADRB2	0.048
527	Prostacyclin receptor	PTGIR	0.0477
5294	Nucleoside diphosphate kinase A	NME1	0.0473
22	30S ribosomal protein S4	rpsD	0.0462
6714	30S ribosomal protein S4	rpsD	0.0462
3685	Catabolite gene activator	crp	0.0452
4655	Adenylate cyclase	cyaC	0.0452
4759	Adenylate cyclase	cyaB2	0.0452
3611	Cytidine deaminase	cdd	0.0451
3707	Cytidine deaminase	cdd	0.0451
4211	Cytidine deaminase	CDA	0.0451
6106	Cytochrome P450 2C18	CYP2C18	0.0449
29	Tubulin beta-1 chain	TUBB1	0.0436
140	30S ribosomal protein S9	rpsI	0.0435
6719	30S ribosomal protein S9	rpsI	0.0435
6725	30S ribosomal protein S9	rpsI	0.0435
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0434
2206	Glucose-6-phosphate isomerase	GPI	0.0429
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0428
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0414
1757	Myeloperoxidase	MPO	0.0414
1124	Sepiapterin reductase	SPR	0.0413
2320	Thymidine kinase, cytosolic	TK1	0.0409
731	HIV-1 protease	HIV-1 protease	0.0407
809	Methionine synthase	MTR	0.0403
2935	Methionine synthase	metH	0.0403
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0403
6085	Fatty acid-binding protein, intestinal	FABP2	0.0399
273	Apoptosis regulator Bcl-2	BCL2	0.0393
4760	Mll3241 protein	mll3241	0.0388
6171	Solute carrier family 28 member 3	SLC28A3	0.0383
558	Solute carrier family 12 member 1	SLC12A1	0.0382
869	Estrogen receptor beta	ESR2	0.0382
5698	Riboflavin synthase alpha chain	ribE	0.0379
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0374
645	Penicillin-binding protein 1A	mrcA	0.0366
5805	Penicillin-binding protein 1A	ponA	0.0366
6185	Penicillin-binding protein 1A	mrcA	0.0366
6799	Penicillin-binding protein 1A	pbpA	0.0366
13	Aminomethyltransferase, mitochondrial	AMT	0.0357
408	Riboflavin kinase	RFK	0.0351
5923	Microtubule-associated protein tau	MAPT	0.0349
5924	Microtubule-associated protein 4	MAP4	0.0349
790	DNA polymerase subunit alpha B	POLA2	0.0348
6218	Pannexin-1	PANX1	0.0348
543	Penicillin-binding protein 1B	mrcB	0.0347
6186	Penicillin-binding protein 1B	ponB	0.0347
6822	Penicillin-binding protein 1b	pbp1b	0.0347
6844	Penicillin-binding protein 1b	pbp1b	0.0347
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0344
702	UMP-CMP kinase	CMPK1	0.0343
2353	Apolipoprotein(a)	LPA	0.0343
404	DNA gyrase subunit A	gyrA	0.0342
6224	DNA gyrase subunit A	gyrA	0.0342
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.034
904	Glutathione S-transferase P	GSTP1	0.034
756	Sex hormone-binding globulin	SHBG	0.0337
1852	Microtubule-associated protein 2	MAP2	0.0337
563	Thyroid peroxidase	TPO	0.0332
3941	Amine oxidase [flavin-containing] A	MAOA	0.033
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0328
633	Penicillin-binding proteins 1A/1B	pbpA	0.0324
2539	Tubulin alpha-1 chain	TUBA4A	0.032
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0319
952	Dipeptidyl peptidase 4	DPP4	0.0317
672	Prostaglandin F2-alpha receptor	PTGFR	0.0312
4226	Uridine phosphorylase 2	UPP2	0.0307
234	Plasminogen	PLG	0.0306
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0302
492	Histamine H1 receptor	HRH1	0.0298
1405	Thiopurine S-methyltransferase	TPMT	0.0294
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0294
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.029
357	Carbonic anhydrase 2	CA2	0.0289
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0282
468	Cytochrome P450 4A11	CYP4A11	0.0281
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.028
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0279
4225	Uridine phosphorylase 1	UPP1	0.0278
3810	Catechol O-methyltransferase	COMT	0.0275
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0275
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0273
477	DNA topoisomerase 4 subunit A	parC	0.027
886	DNA topoisomerase 4 subunit A	parC	0.027
6226	DNA topoisomerase 4 subunit A	parC	0.027
5353	Glutamate decarboxylase alpha	gadA	0.027
161	Tubulin beta chain	TUBB	0.0269
312	Tubulin beta chain	TUB2	0.0269
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0267
654	Flavin reductase	BLVRB	0.0266
413	Amidophosphoribosyltransferase	PPAT	0.0262
2515	Amidophosphoribosyltransferase	purF	0.0262
3714	Amidophosphoribosyltransferase	purF	0.0262
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0261
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0261
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0261
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0259
908	Glutathione S-transferase theta-1	GSTT1	0.0258
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0258
844	Epidermal growth factor receptor	EGFR	0.0257
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0257
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0257
6043	Putative G-protein coupled receptor 44	GPR44	0.0256
6033	High affinity interleukin-8 receptor A	CXCR1	0.0256
1	Peptidoglycan synthetase ftsI	ftsI	0.0254
4155	Peptidoglycan synthetase ftsI	ftsI	0.0254
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0253
887	DNA gyrase subunit B	gyrB	0.0252
4150	DNA gyrase subunit B	gyrB	0.0252
6225	DNA gyrase subunit B	gyrB	0.0252
871	Glucocorticoid receptor	NR3C1	0.0251
4120	NADPH--cytochrome P450 reductase	POR	0.0249
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0249
59	AMT protein	AMT	0.0249
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0249
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0249
438	Taste receptor type 1 member 2	TAS1R2	0.0248
2929	(S)-2-haloacid dehalogenase	dhlB	0.0248
2995	(S)-2-haloacid dehalogenase	Not Available	0.0248
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0247
3426	Glutamine synthetase	glnA	0.0246
3987	Glutamine synthetase	GLUL	0.0246
1353	DNA topoisomerase 1	TOP1	0.0245
3552	DNA topoisomerase 1	topA	0.0245
115	Penicillin-binding protein 2	mrdA	0.024
6069	Penicillin-binding protein 2	mrdA	0.024
6118	Penicillin-binding protein 2	penA	0.024
6187	Penicillin-binding protein 2	pbpA	0.024
6686	Penicillin-binding protein 2	pbp2	0.024
6939	Penicillin-binding protein 2	mrdA	0.024
7163	Penicillin-binding protein 2	pbpA	0.024
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.024
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0239
6042	Prostaglandin reductase 2	PTGR2	0.0238
840	Methionine synthase reductase, mitochondrial	MTRR	0.0238
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0234
4192	DNA topoisomerase 2-beta	TOP2B	0.0232
1867	Major prion protein	PRNP	0.0232
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0232
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0229
183	Vascular endothelial growth factor A	VEGFA	0.0226
504	Mast/stem cell growth factor receptor	KIT	0.0224
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0224
6031	Cytochrome P450 3A43	CYP3A43	0.0223
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0221
26	Vascular endothelial growth factor receptor 3	FLT4	0.0218
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0216
2361	Response regulator pleD	pleD	0.0216
2516	GMP reductase 1	GMPR	0.0216
1313	Lactoylglutathione lyase	GLO1	0.0215
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0211
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0211
117	Sterol O-acyltransferase 1	SOAT1	0.0211
629	Alpha-2B adrenergic receptor	ADRA2B	0.021
318	Alpha-2A adrenergic receptor	ADRA2A	0.021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0209
891	Dihydropteroate synthase	folP	0.0207
5359	Dihydropteroate synthase	folP	0.0207
7175	Dihydropteroate synthase	sulI	0.0207
146	Androgen receptor	AR	0.0207
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
378	Alpha-2C adrenergic receptor	ADRA2C	0.0205
4106	Guanylate kinase	GUK1	0.0202
4516	Guanylate kinase	gmk	0.0202
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0202
3923	Cholinesterase	BCHE	0.0201
6207	30S ribosomal protein S14	rpsN	0.02
6209	30S ribosomal protein S19	rpsS	0.02
6712	30S ribosomal protein S19	rpsS	0.02
6726	30S ribosomal protein S19	rpsS	0.02
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.02
2016	Dipeptidase 1	DPEP1	0.0197
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0197
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0194
380	Cytochrome P450 17A1	CYP17A1	0.0193
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0192
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0191
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0188
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0188
400	Coagulation factor IX	F9	0.0187
5461	Coagulation factor IX	F9	0.0187
824	Sodium-dependent serotonin transporter	SLC6A4	0.0186
3884	SHMT2 protein	SHMT2	0.0184
3901	SHMT2 protein	SHMT2	0.0184
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0184
3879	Serine hydroxymethyltransferase 2	Not Available	0.0184
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0184
592	Carbonic anhydrase 4	CA4	0.0182
407	Vascular endothelial growth factor receptor 2	KDR	0.0182
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0181
6500	Phospholipase A2	PLA2G1B	0.018
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0178
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0177
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0177
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0177
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0177
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0177
295	Carbonic anhydrase 1	CA1	0.0175
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0175
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0173
604	Vitamin K-dependent protein Z	PROZ	0.0172
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0172
811	Translocator protein	TSPO	0.0172
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0171
1389	Transforming growth factor beta-1	TGFB1	0.0169
4217	Telomerase reverse transcriptase	TERT	0.0168
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0168
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0167
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
1198	Serum paraoxonase/arylesterase 1	PON1	0.0167
6223	Penicillin-binding protein 1C	pbpC	0.0167
124	Histamine H2 receptor	HRH2	0.0165
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0164
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0163
3300	Xanthine phosphoribosyltransferase	xpt	0.0163
3681	Xanthine phosphoribosyltransferase	gpt	0.0163
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0163
614	Progesterone receptor	PGR	0.0162
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0161
556	Alpha-1A adrenergic receptor	ADRA1A	0.0161
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0159
3179	2-isopropylmalate synthase	leuA	0.0159
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0157
53	Solute carrier family 12 member 5	SLC12A5	0.0156
663	Solute carrier family 12 member 4	SLC12A4	0.0156
422	Vitamin K-dependent protein C	PROC	0.0156
1245	Vitamin K-dependent protein S	PROS1	0.0156
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0156
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0153
507	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial	MMAB	0.0152
3916	Methylmalonic aciduria and homocystinuria type C protein	MMACHC	0.0152
354	Methylmalonic aciduria type A protein, mitochondrial	MMAA	0.0152
398	Transcobalamin-2	TCN2	0.0152
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0152
265	Transcobalamin-1	TCN1	0.0152
376	Amnionless protein	AMN	0.0152
854	Methylmalonyl-CoA mutase, mitochondrial	MUT	0.0152
1224	Cubilin	CUBN	0.0152
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0151
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0151
2391	Ferrochelatase	hemH	0.0151
6502	Ferrochelatase	DKFZp686P18130	0.0151
1591	Ferrochelatase, mitochondrial	FECH	0.0151
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.015
6168	Solute carrier family 22 member 16	SLC22A16	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0148
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0147
1760	Aminopeptidase N	ANPEP	0.0147
6843	Aminopeptidase N	pepN	0.0147
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0147
310	Solute carrier family 12 member 2	SLC12A2	0.0145
737	Mineralocorticoid receptor	NR3C2	0.0145
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0144
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0144
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0144
831	D(2) dopamine receptor	DRD2	0.0143
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0143
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
5650	NimA-related protein	DR_0842	0.0142
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0141
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0141
4237	50S ribosomal protein L22	rplV	0.0141
65	Matrix metalloproteinase-9	Not Available	0.014
6220	Aryl hydrocarbon receptor	AHR	0.014
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0139
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0139
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0138
4122	Histone deacetylase 2	HDAC2	0.0138
3809	Estrogen-related receptor gamma	ESRRG	0.0138
1654	Interleukin-1 beta	IL1B	0.0137
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0137
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0136
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0136
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0136
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0135
2021	Thrombomodulin	THBD	0.0135
165	FL cytokine receptor	FLT3	0.0134
6501	Fatty acid-binding protein, liver	FABP1	0.0133
6126	Carbonic anhydrase 7	CA7	0.0133
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0132
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0131
3760	Penicillin-binding protein 5 precursor	dacA	0.0131
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0131
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0131
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0131
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0131
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0131
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0131
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0131
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0131
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0131
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0131
6559	Cytochrome c oxidase subunit 2	ctaC	0.0131
6669	Cytochrome c oxidase subunit 2	ctaC	0.0131
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0131
6558	Cytochrome c oxidase subunit 1	ctaD	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0129
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
2567	Thymidylate synthase thyX	thyX	0.0128
6837	Serine/threonine-protein kinase 17B	STK17B	0.0128
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0128
4275	PCZA361.16	Not Available	0.0128
4276	DNA polymerase III subunit epsilon	dnaQ	0.0128
2410	Deoxyuridine 5'-triphosphate nucleotidohydrolase	dut	0.0127
2490	Deoxyuridine 5'-triphosphate nucleotidohydrolase	dut	0.0127
3334	Deacetoxycephalosporin C synthetase	cefE	0.0127
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0127
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0127
819	Penicillin-binding protein 4	dacB	0.0125
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0125
896	Glutathione S-transferase Mu 1	GSTM1	0.0125
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0125
461	Glycine receptor subunit alpha-3	GLRA3	0.0124
798	Osteocalcin	BGLAP	0.0124
130	Prostacyclin synthase	PTGIS	0.0124
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0123
317	Methionine-R-sulfoxide reductase	SEPX1	0.0123
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0122
480	Methionine-R-sulfoxide reductase B2	MSRB2	0.0122
3996	Betaine--homocysteine S-methyltransferase 2	BHMT2	0.0122
3921	Methionine adenosyltransferase 2 subunit beta	MAT2B	0.0122
3995	Methionyl-tRNA synthetase, mitochondrial	MARS2	0.0122
600	Methionyl-tRNA synthetase, cytoplasmic	MARS	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
1830	5'-nucleotidase	NT5E	0.0122
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0121
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.012
2540	Choloylglycine hydrolase	cbh	0.012
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0118
239	Coagulation factor X	F10	0.0117
6163	Copper-transporting ATPase 2	ATP7B	0.0117
6165	Copper-transporting ATPase 1	ATP7A	0.0117
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0117
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0117
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0116
125	DNA polymerase beta	POLB	0.0116
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0116
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0114
2555	Pol polyprotein	pol	0.0114
3242	Pol polyprotein	gag-pol	0.0114
3471	Pol polyprotein	gag-pro-pol	0.0114
5256	Pol polyprotein	pol	0.0114
6469	Pol polyprotein	gag-pol	0.0114
6565	Pol polyprotein	Not Available	0.0114
5787	Angiopoietin-1 receptor	TEK	0.0113
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0112
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
6146	High affinity copper uptake protein 1	SLC31A1	0.0111
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0111
284	DNA-directed RNA polymerase beta chain	rpoB	0.0111
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0111
494	Caspase-1	CASP1	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
632	Alpha-1B adrenergic receptor	ADRA1B	0.011
369	Coagulation factor VII	F7	0.011
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.011
992	Protein tyrosine kinase 2 beta	PTK2B	0.0109
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0109
2443	Azurin	azu	0.0108
2599	Tyrosine-protein kinase HCK	HCK	0.0108
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0107
23	D(1A) dopamine receptor	DRD1	0.0107
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0107
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0107
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0107
2757	Inorganic pyrophosphatase	ppa	0.0107
6238	Inorganic pyrophosphatase	ppa	0.0107
6968	Inorganic pyrophosphatase	PPA1	0.0107
1507	Cytochrome c	CYCS	0.0107
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0107
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0107
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0106
705	Glutamate receptor 1	GRIA1	0.0106
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0106
928	Nicotinic acid receptor 2	GPR109B	0.0105
860	Nicotinamide N-methyltransferase	NNMT	0.0105
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0105
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0105
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0105
699	Nicotinic acid receptor 1	GPR109A	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0104
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0104
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0103
3932	Glutathione S-transferase A2	GSTA2	0.0103
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0103
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0102
191	Peptide methionine sulfoxide reductase	MSRA	0.0102
5482	Sialidase-2	NEU2	0.0101
847	Mu-type opioid receptor	OPRM1	0.01
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0099
6131	Carbonic anhydrase 14	CA14	0.0099
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0099
2251	Thymidylate kinase	tmk	0.0098
2254	Thymidylate kinase	DTYMK	0.0098
3522	Thymidylate kinase	tmk	0.0098
465	Calmodulin	CALM1	0.0098
193	Beta-1 adrenergic receptor	ADRB1	0.0098
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0097
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0097
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
185	Vasopressin V1a receptor	AVPR1A	0.0096
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0095
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0095
566	Serotransferrin	TF	0.0094
2647	RNA-directed RNA polymerase	P2	0.0094
322	Vasopressin V2 receptor	AVPR2	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
2077	Caspase-3	CASP3	0.0093
1178	Adenosine A2a receptor	ADORA2A	0.0093
469	Annexin A1	ANXA1	0.0093
260	Cytochrome P450 51	ERG11	0.0092
761	Cytochrome P450 51	ERG11	0.0092
3163	Cytochrome P450 51	cyp51	0.0092
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0092
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0092
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0092
6122	Carbonic anhydrase 3	CA3	0.0092
517	Alcohol dehydrogenase 1C	ADH1C	0.0092
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0092
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0092
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
696	Kappa-type opioid receptor	OPRK1	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.009
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.009
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.009
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0089
7	Nitric oxide synthase, inducible	NOS2	0.0088
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0088
3010	Regulatory protein blaR1	blaR1	0.0087
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0087
2149	Angiogenin	ANG	0.0087
1192	Sulfotransferase 1A1	SULT1A1	0.0086
3007	Carbonic anhydrase 12	CA12	0.0086
4205	Carbonic anhydrase 9	CA9	0.0086
3014	Ribonuclease UK114	HRSP12	0.0086
5428	Replication protein	repA	0.0086
3617	Non-heme chloroperoxidase	cpo	0.0086
5426	Non-heme chloroperoxidase	cpo	0.0086
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0086
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0086
3018	HTH-type transcriptional regulator malT	malT	0.0086
467	Delta-type opioid receptor	OPRD1	0.0086
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0085
16	Adenosine A1 receptor	ADORA1	0.0085
2727	S-adenosylmethionine synthetase	metK	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0084
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.0084
3361	Serpin B5	SERPINB5	0.0084
5694	Transcription antiterminator licT	licT	0.0084
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0084
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0083
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0082
4600	Malonamidase E2	Not Available	0.0082
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0081
1039	Histone deacetylase 9	HDAC9	0.0081
5880	Thrombopoietin receptor	MPL	0.0081
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0081
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.008
1629	Transcription factor AP-1	JUN	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
818	50S ribosomal protein L10	rplJ	0.0079
2808	Chloramphenicol acetyltransferase 3	cat3	0.0079
2717	Folylpolyglutamate synthase	fgs	0.0079
76	Nitric-oxide synthase, brain	NOS1	0.0077
6014	Cytochrome P450 2A13	CYP2A13	0.0077
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0077
789	Alpha-1D adrenergic receptor	ADRA1D	0.0077
1050	Bile salt sulfotransferase	SULT2A1	0.0076
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0075
54	Prothrombin	F2	0.0075
1630	Integrin beta-2	ITGB2	0.0075
3957	Adenosine deaminase	ADA	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
6182	Cytochrome P450 2J2	CYP2J2	0.0074
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0074
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0074
4026	Aspartyl aminopeptidase	DNPEP	0.0074
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0074
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0074
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0074
1047	Excitatory amino acid transporter 2	SLC1A2	0.0074
1912	Excitatory amino acid transporter 1	SLC1A3	0.0074
4019	Excitatory amino acid transporter 4	SLC1A6	0.0074
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0074
4016	Excitatory amino acid transporter 5	SLC1A7	0.0074
664	Glutamate decarboxylase 2	GAD2	0.0074
3890	Glutamate decarboxylase 2	GAD2	0.0074
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0074
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0074
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0074
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0074
922	Glutamate receptor 4	GRIA4	0.0074
927	Metabotropic glutamate receptor 8	GRM8	0.0074
4020	Glutamyl aminopeptidase	ENPEP	0.0074
4017	5-oxoprolinase	OPLAH	0.0074
4018	Glutamate receptor delta-2 subunit	GRID2	0.0074
925	Metabotropic glutamate receptor 4	GRM4	0.0074
926	Metabotropic glutamate receptor 7	GRM7	0.0074
4027	Glutamate receptor delta-1 subunit	GRID1	0.0074
6395	Myosin-14	MYH14	0.0074
2958	Probable tautomerase ydcE	pptA	0.0074
2573	Cocaine esterase	cocE	0.0074
7263	Cocaine esterase	Not Available	0.0074
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0074
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0073
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0073
3115	Ras-related protein Rab-9	RAB9A	0.0073
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0072
1648	Elastin	ELN	0.0072
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0071
3856	Fibroblast growth factor receptor 3	FGFR3	0.0071
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
2298	Cytochrome P450-cam	camC	0.0069
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0068
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0068
1517	Beta-3 adrenergic receptor	ADRB3	0.0068
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0067
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0067
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0067
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0067
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0067
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0067
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0066
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0066
36	Insulin receptor	INSR	0.0066
2795	Methionine aminopeptidase 2	METAP2	0.0066
1714	Mitogen-activated protein kinase 3	MAPK3	0.0066
768	FK506-binding protein 1A	FKBP1A	0.0066
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0065
6138	Multidrug resistance protein 3	ABCB4	0.0065
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0064
1525	Heparin-binding growth factor 2	FGF2	0.0064
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0064
6210	Tubulin delta chain	TUBD1	0.0064
6212	Tubulin gamma-1 chain	TUBG1	0.0064
6211	Tubulin epsilon chain	TUBE1	0.0064
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0064
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0064
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0063
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0063
122	P2Y purinoceptor 12	P2RY12	0.0063
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0062
291	Nitric-oxide synthase, endothelial	NOS3	0.0062
3270	Elongation factor G	fusA	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0062
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0062
4210	Toll-like receptor 4	TLR4	0.0062
625	Glutamate carboxypeptidase 2	FOLH1	0.0062
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0062
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0062
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0062
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0062
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0062
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0062
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0062
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0062
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0062
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0061
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0061
6044	Serum paraoxonase/lactonase 3	PON3	0.0061
4534	Cytohesin-2	CYTH2	0.0061
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.006
482	Glycine receptor subunit alpha-1	GLRA1	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.006
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.006
921	Glutamate receptor 2	GRIA2	0.006
51	Muscarinic acetylcholine receptor M3	CHRM3	0.006
751	Potassium channel subfamily K member 6	KCNK6	0.0059
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0059
665	Phosphoserine aminotransferase	PSAT1	0.0059
4652	Phosphoserine aminotransferase	serC	0.0059
420	Glutamate decarboxylase 1	GAD1	0.0059
3900	Glutamate decarboxylase 1	GAD1	0.0059
3668	Maltose-binding periplasmic protein precursor	malE	0.0059
397	Monocarboxylate transporter 3	SLC16A8	0.0059
1291	cAMP response element-binding protein	CREB1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
195	Monocarboxylate transporter 7	SLC16A6	0.0058
218	Monocarboxylate transporter 5	SLC16A4	0.0058
429	Monocarboxylate transporter 6	SLC16A5	0.0058
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0058
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0058
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
707	72 kDa type IV collagenase	MMP2	0.0057
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0057
916	Metabotropic glutamate receptor 1	GRM1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0056
572	Integrin alpha-L	ITGAL	0.0056
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0056
2693	Heat-labile enterotoxin B chain	eltB	0.0056
777	Tumor necrosis factor	TNF	0.0056
923	Glutamate receptor 3	GRIA3	0.0055
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0055
1671	Excitatory amino acid transporter 3	SLC1A1	0.0055
6645	D-amino-acid oxidase	DAO	0.0055
172	Potassium channel subfamily K member 1	KCNK1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
3877	Growth-inhibiting protein 18	GIG18	0.0054
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
459	Retinoic acid receptor RXR-alpha	RXRA	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
3939	Amine oxidase [flavin-containing] B	MAOB	0.0053
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0053
2592	Beta-galactosidase	lacZ	0.0053
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
52	Pyruvate kinase isozymes R/L	PKLR	0.0052
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0052
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
763	Tyrosine aminotransferase	TAT	0.0051
5493	Tyrosine aminotransferase	Not Available	0.0051
735	Alanine aminotransferase 1	GPT	0.0051
3904	Alanine aminotransferase 2	GPT2	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
232	Corticosteroid-binding globulin	SERPINA6	0.005
6228	Nuclear receptor coactivator 1	NCOA1	0.005
315	Arginase-1	ARG1	0.005
436	5-hydroxytryptamine 2B receptor	HTR2B	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0049
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0049
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0049
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0049
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0049
771	Pyruvate carboxylase, mitochondrial	PC	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0047
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0047
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0047
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0047
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0047
4034	Glutaredoxin-1	GLRX	0.0046
1928	Leukotriene C4 synthase	LTC4S	0.0046
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0046
4037	Hypothetical protein	GPX1	0.0046
4297	Hypothetical protein	SP_1951	0.0046
4521	Hypothetical protein	BC_2969	0.0046
4540	Hypothetical protein	TM_1070	0.0046
4555	Hypothetical protein	MT1739	0.0046
4569	Hypothetical protein	mshD	0.0046
4578	Hypothetical protein	PA3270	0.0046
4747	Hypothetical protein	PA3967	0.0046
5177	Hypothetical protein	TM_0096	0.0046
5194	Hypothetical protein	PA1204	0.0046
5240	Hypothetical protein	Rv2991	0.0046
5370	Hypothetical protein	TM_1158	0.0046
5710	Hypothetical protein	Tb927.5.1360	0.0046
4029	Microsomal glutathione S-transferase 3	MGST3	0.0046
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0046
907	Glutathione peroxidase 2	GPX2	0.0046
4032	Microsomal glutathione S-transferase 1	MGST1	0.0046
910	Epididymal secretory glutathione peroxidase	GPX5	0.0046
4036	Glutathione peroxidase 6	GPX6	0.0046
903	Glutathione S-transferase A5	GSTA5	0.0046
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0046
4040	Glutathione peroxidase 7	GPX7	0.0046
911	Glutathione peroxidase 3	GPX3	0.0046
906	Glutathione peroxidase 1	GPX1	0.0046
900	Glutathione S-transferase A4	GSTA4	0.0046
4035	Glutathione S-transferase Mu 5	GSTM5	0.0046
4033	S-formylglutathione hydrolase	ESD	0.0046
4042	Glutathione transferase omega-2	GSTO2	0.0046
4038	Glutathione peroxidase 4	GPX4	0.0046
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0046
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0046
1618	High affinity nerve growth factor receptor	NTRK1	0.0045
6128	Carbonic anhydrase-related protein 10	CA10	0.0044
6133	Sodium channel subunit beta-2	SCN2B	0.0044
6134	Sodium channel subunit beta-3	SCN3B	0.0044
6132	Sodium channel subunit beta-1	SCN1B	0.0044
6135	Sodium channel subunit beta-4	SCN4B	0.0044
6129	Carbonic anhydrase-related protein 11	CA11	0.0044
6127	Carbonic anhydrase-related protein	CA8	0.0044
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
822	Aldose reductase	AKR1B1	0.0043
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0043
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0043
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0042
898	Glutathione S-transferase A3	GSTA3	0.0042
897	Glutathione S-transferase kappa 1	GSTK1	0.0042
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0042
131	Synaptic vesicular amine transporter	SLC18A2	0.0041
909	Maleylacetoacetate isomerase	GSTZ1	0.0041
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0041
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0041
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0041
905	Glutathione transferase omega-1	GSTO1	0.004
899	Glutathione S-transferase Mu 3	GSTM3	0.004
714	Glutathione reductase, mitochondrial	GSR	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.004
4041	Microsomal glutathione S-transferase 2	MGST2	0.004
474	Acetylcholinesterase	ACHE	0.004
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0039
2408	Tyrosine-protein kinase SYK	SYK	0.0039
84	Nuclear receptor 0B1	NR0B1	0.0039
713	Sodium-dependent dopamine transporter	SLC6A3	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0038
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0038
6130	Carbonic anhydrase 13	CA13	0.0038
5934	Cytochrome P450 26A1	CYP26A1	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
106	Cannabinoid receptor 2	CNR2	0.0037
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0037
2165	Glutathione S-transferase Mu 2	GSTM2	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
6102	Arylamine N-acetyltransferase 2	NAT2	0.0036
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
1569	G1/S-specific cyclin-D1	CCND1	0.0036
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
936	Ephrin type-A receptor 2	EPHA2	0.0035
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0035
901	Glutathione S-transferase Mu 4	GSTM4	0.0035
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0034
760	Fibroblast growth factor 1	FGF1	0.0034
638	D(3) dopamine receptor	DRD3	0.0034
1656	CYP2B protein	CYP2B	0.0033
634	Squalene monooxygenase	SQLE	0.0033
7196	Squalene monooxygenase	ERG1	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0033
595	Fibrinogen alpha chain	FGA	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
4031	Glutathione S-transferase A1	GSTA1	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
823	Fibroblast growth factor receptor 2	FGFR2	0.003
484	Tyrosine-protein kinase ABL2	ABL2	0.003
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.003
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.003
976	Platelet glycoprotein IX	GP9	0.003
6824	Tyrosine-protein kinase Lyn	LYN	0.003
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
683	Potassium transporter	GK0582	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0028
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0028
1010	Cytochrome P450 51A1	CYP51A1	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0027
666	NADP-dependent malic enzyme	ME1	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1025	Aquaporin-1	AQP1	0.0027
2300	Lysozyme	E	0.0027
3633	Lysozyme	R	0.0027
5597	Lysozyme	17	0.0027
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0027
1864	RET proto-oncogene	RET	0.0027
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0027
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0027
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0027
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
716	5-hydroxytryptamine 7 receptor	HTR7	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
6432	Transporter	snf	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
780	Retinoic acid receptor RXR-gamma	RXRG	0.0025
730	Retinoic acid receptor alpha	RARA	0.0024
2236	Casein kinase II subunit alpha	CSNK2A1	0.0024
444	Alcohol dehydrogenase 1B	ADH1B	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
6231	Pepsin A	PGA3	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
1176	Mitogen-activated protein kinase 1	MAPK1	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
2216	Fibroblast growth factor receptor 4	FGFR4	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0023
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0023
88	Retinoic acid receptor RXR-beta	RXRB	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
6103	Arylamine N-acetyltransferase 1	NAT1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
3830	Calreticulin	CALR	0.0022
1196	Complement decay-accelerating factor	CD55	0.0021
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0021
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0021
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0021
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0021
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0021
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0021
2207	Rhodopsin	RHO	0.0021
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
283	SEC14-like protein 2	SEC14L2	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6755	Poliovirus receptor	PVR	0.002
2240	Cell division protein kinase 2	CDK2	0.002
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
1058	Cell division protein kinase 5	CDK5	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
1992	Vitamin D-binding protein	GC	0.002
5798	Mitogen-activated protein kinase 11	MAPK11	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0018
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0018
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0018
5332	MtdA bifunctional protein	mtdA	0.0018
4403	Protein iolS	iolS	0.0018
5322	Oxidoreductase ydhF	ydhF	0.0018
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0018
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0018
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0018
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0018
5330	General stress protein 69	yhdN	0.0018
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0018
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
267	Plasminogen activator inhibitor 1	SERPINE1	0.0017
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0017
605	Fumarate reductase flavoprotein subunit	frdA	0.0016
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0016
3673	Fumarate reductase flavoprotein subunit	fccA	0.0016
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0016
6549	Fumarate reductase flavoprotein subunit	frdA	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6221	Steroid hormone receptor ERR1	ESRRA	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
4582	Putative pteridine reductase 2	ptr2	0.0016
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0016
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0016
5073	Ferredoxin--NADP reductase	petH	0.0016
5076	Ferredoxin--NADP reductase	fpr	0.0016
5119	Ferredoxin--NADP reductase	petH	0.0016
5121	Ferredoxin--NADP reductase	fpr	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
5328	Prostaglandin F synthase	Tb11.02.2310	0.0016
989	L-xylulose reductase	DCXR	0.0016
3446	NADP-dependent alcohol dehydrogenase	adh	0.0016
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0016
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0016
2636	Shikimate dehydrogenase	aroE	0.0016
3515	Shikimate dehydrogenase	aroE	0.0016
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0016
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0016
2286	Isocitrate dehydrogenase [NADP]	icd	0.0016
2302	Isocitrate dehydrogenase [NADP]	icd	0.0016
2771	Isocitrate dehydrogenase [NADP]	icd	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
432	D(4) dopamine receptor	DRD4	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0015
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0015
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0015
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0015
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0015
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0015
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0015
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0015
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0015
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0015
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0015
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0015
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0015
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0015
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0015
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0015
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0015
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0015
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0015
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0015
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0015
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0015
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0015
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0015
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0015
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0015
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0015
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0015
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0015
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0015
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0015
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0015
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0015
107	C-4 methylsterol oxidase	SC4MOL	0.0015
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0015
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0015
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0015
644	Heme oxygenase 2	HMOX2	0.0015
4982	Heme oxygenase 2	pbsA2	0.0015
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0015
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0015
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0015
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0015
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0015
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0015
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0015
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0015
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0015
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0015
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0015
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0015
729	GDP-L-fucose synthetase	TSTA3	0.0015
3463	GDP-L-fucose synthetase	fcl	0.0015
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0015
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0015
167	L-lactate dehydrogenase C chain	LDHC	0.0015
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0015
206	3-keto-steroid reductase	HSD17B7	0.0015
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0015
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0015
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0015
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0015
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0015
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0015
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0015
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0015
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0015
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0015
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0015
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0015
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0015
643	Peroxisomal bifunctional enzyme	EHHADH	0.0015
34	7-dehydrocholesterol reductase	DHCR7	0.0015
711	UDP-glucose 6-dehydrogenase	UGDH	0.0015
3672	UDP-glucose 6-dehydrogenase	hasB	0.0015
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0015
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0015
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0015
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0015
1275	Estrogen sulfotransferase	SULT1E1	0.0015
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.0015
6297	Prostaglandin reductase 1	PTGR1	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0015
4531	Putative ketoacyl reductase	actIII	0.0015
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0015
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
3062	Aspartate-semialdehyde dehydrogenase	asd	0.0014
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0014
328	Sorbitol dehydrogenase	SORD	0.0014
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0014
597	Dihydropteridine reductase	QDPR	0.0014
396	Alcohol dehydrogenase 4	ADH4	0.0014
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
233	Potassium channel subfamily K member 2	KCNK2	0.0014
2675	Pteridine reductase 1	PTR1	0.0014
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0014
857	Malate dehydrogenase, mitochondrial	MDH2	0.0014
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0013
2159	Quinone oxidoreductase	CRYZ	0.0013
77	L-lactate dehydrogenase B chain	LDHB	0.0013
12	Alcohol dehydrogenase class 3	ADH5	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
6026	Alcohol dehydrogenase 6	ADH6	0.0013
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0013
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
473	L-lactate dehydrogenase A chain	LDHA	0.0013
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0013
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
694	Matrix protein 2	M	0.0012
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
292	Activin receptor type-1	ACVR1	0.0012
810	Heme oxygenase 1	HMOX1	0.0012
3391	Heme oxygenase 1	pbsA1	0.0012
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6859	Protein S100-A4	S100A4	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0011
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0011
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
279	Tyrosinase	TYR	0.0011
163	D(1B) dopamine receptor	DRD5	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
427	Substance-P receptor	TACR1	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
3937	Fatty-acid amide hydrolase	FAAH	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
6316	ADP-ribosylation factor 1	ARF1	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
3221	Cytochrome c4	cc4	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
2802	Endoglucanase G	celCCG	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
4943	Cytochrome c6	petJ	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
5000	HemO	hemO	0.0003
4916	Cyanoglobin	glbN	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4984	Neuroglobin	NGB	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4961	Hemophore HasA	hasA	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4910	Cytoglobin	CYGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4909	CooA protein	cooA	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4952	Catalase/peroxidase	katA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
164	Histamine H4 receptor	HRH4	0.0003
4920	Peroxidase/catalase	katG	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4948	Cytochrome c-553	Not Available	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
4990	PpcA	ppcA	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
518	Peroxidase/catalase T	katG	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00563 - Methotrexate

Targets

Enzymes

Transporters

Carriers

Predictions