DT-Web: DB00586

Identification

Name

Diclofenac

Accession Number

DB00586 (APRD00527)

Type

small molecule

Description

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

296.149

Groups

approved

Monoisotopic Weight

295.016684015

Pharmacology

Indication

For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.

Mechanism of action

The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.

Absorption

Completely absorbed from the gastrointestinal tract.

Protein binding

More than 99%

Biotransformation

Hepatic

Route of elimination

Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites.

Toxicity

Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD₅₀=390mg/kg (orally in mice)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alendronate	Increased risk of gastric toxicity
Anisindione	The NSAID, diclofenac, may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine	Monitor for nephrotoxicity
Dicumarol	The NSAID, diclofenac, may increase the anticoagulant effect of dicumarol.
Difluprednate	NSAIDs may slow healing.
Eltrombopag	Eltrombopag increases levels of Diclofenac via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Lithium	The NSAID, diclofenac, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Methotrexate	The NSAID, diclofenac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Rifampin	Rifampin, a CYP2C9 inducer, may increase the metabolism of diclofenac.
Tacrine	The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Diclofenac, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Diclofenac is initiated, discontinued or if the dose is changed.
Telmisartan	Concomitant use of Telmisartan and Diclofenac may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Diclofenac, may antagonize the antihypertensive effect of Timolol.
Tizanidine	Diclofenac may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Trandolapril	The NSAID, Diclofenac, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Diclofenac is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Diclofenac. Monitor for increased bleeding during concomitant thearpy.
Vilazodone	Increased risk of bleeding with concomitant use of NSAIDs with vilazodone.
Voriconazole	Voriconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of diclofenac by decreasing its metabolism. Renal impairment may increase the risk of diclofenac adverse effects. Monitor for changes in therapeutic and adverse effects of diclofenac if voriconazole is initiated, discontinued or dose changed.
Warfarin	The antiplatelet effects of oral diclofenac may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Take with food to reduce irritation.
Avoid alcohol.

Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Kirchheiner J, Meineke I, Steinbach N, Meisel C, Roots I, Brockmoller J: Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. Br J Clin Pharmacol. 2003 Jan;55(1):51-61. - Pubmed Blomme EA, Chinn KS, Hardy MM, Casler JJ, Kim SH, Opsahl AC, Hall WA, Trajkovic D, Khan KN, Tripp CS: Selective cyclooxygenase-2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. Br J Dermatol. 2003 Feb;148(2):211-23. - Pubmed Beubler E: [Pharmacology of cyclooxygenase 2 inhibition] Wien Med Wochenschr. 2003;153(5-6):95-9. - Pubmed Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. - Pubmed Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ: A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. - Pubmed
DTHybrid score	0.8632
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	yes
Actions	inhibitor
References	Calkin AC, Sudhir K, Honisett S, Williams MR, Dawood T, Komesaroff PA: Rapid potentiation of endothelium-dependent vasodilation by estradiol in postmenopausal women is mediated via cyclooxygenase 2. J Clin Endocrinol Metab. 2002 Nov;87(11):5072-5. - Pubmed Kirchheiner J, Meineke I, Steinbach N, Meisel C, Roots I, Brockmoller J: Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. Br J Clin Pharmacol. 2003 Jan;55(1):51-61. - Pubmed Kampfer H, Brautigam L, Geisslinger G, Pfeilschifter J, Frank S: Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. J Invest Dermatol. 2003 May;120(5):880-90. - Pubmed Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. - Pubmed Hinz B, Rau T, Auge D, Werner U, Ramer R, Rietbrock S, Brune K: Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin Pharmacol Ther. 2003 Sep;74(3):222-35. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.992
Arachidonate 5-lipoxygenase
Name	Arachidonate 5-lipoxygenase
Gene Name	ALOX5
Pharmacological action	yes
Actions	potentiator
References	Charlier C, Michaux C: Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2003 Jul-Aug;38(7-8):645-59. - Pubmed Kudo C, Kori M, Matsuzaki K, Yamai K, Nakajima A, Shibuya A, Niwa H, Kamisaki Y, Wada K: Diclofenac inhibits proliferation and differentiation of neural stem cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. - Pubmed Whittle BJ: Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. Curr Opin Pharmacol. 2004 Dec;4(6):538-45. - Pubmed
DTHybrid score	0.4585
Sodium channel protein type 4 subunit alpha
Name	Sodium channel protein type 4 subunit alpha
Gene Name	SCN4A
Pharmacological action	yes
Actions	inhibitor
References	Yang YC, Kuo CC: An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+. J Gen Physiol. 2005 May;125(5):465-81. Epub 2005 Apr 11. - Pubmed Voilley N: Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs). Curr Drug Targets Inflamm Allergy. 2004 Mar;3(1):71-9. - Pubmed Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB: Acid-induced pain and its modulation in humans. J Neurosci. 2004 Dec 1;24(48):10974-9. - Pubmed
DTHybrid score	0.2302
Amiloride-sensitive cation channel 2, neuronal
Name	Amiloride-sensitive cation channel 2, neuronal
Gene Name	ACCN2
Pharmacological action	yes
Actions	inhibitor
References	Voilley N, de Weille J, Mamet J, Lazdunski M: Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci. 2001 Oct 15;21(20):8026-33. - Pubmed
DTHybrid score	0.1751
Potassium voltage-gated channel subfamily KQT member 2
Name	Potassium voltage-gated channel subfamily KQT member 2
Gene Name	KCNQ2
Pharmacological action	yes
Actions	other
References	Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. - Pubmed Xiong Q, Gao Z, Wang W, Li M: Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci. 2008 Feb;29(2):99-107. Epub 2008 Jan 18. - Pubmed
DTHybrid score	0.353
Potassium voltage-gated channel subfamily KQT member 3
Name	Potassium voltage-gated channel subfamily KQT member 3
Gene Name	KCNQ3
Pharmacological action	yes
Actions	other
References	Xiong Q, Gao Z, Wang W, Li M: Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci. 2008 Feb;29(2):99-107. Epub 2008 Jan 18. - Pubmed Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. - Pubmed
DTHybrid score	0.3724
Phospholipase A2, membrane associated
Name	Phospholipase A2, membrane associated
Gene Name	PLA2G2A
Pharmacological action	unknown
Actions	inhibitor
References	- Madanick RD, O'Loughlin CJ, Barkin JS: Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography. Dig Dis Sci. 2005 May;50(5):879-81. - Pubmed Singh N, Jabeen T, Sharma S, Somvanshi RK, Dey S, Srinivasan A, Singh TP: Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution. Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):410-6. Epub 2006 Mar 18. - Pubmed Makela A, Kuusi T, Schroder T: Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scand J Clin Lab Invest. 1997 Aug;57(5):401-7. - Pubmed
DTHybrid score	1.1638

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Obach RS, Reed-Hagen AE: Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. Drug Metab Dispos. 2002 Jul;30(7):831-7. - Pubmed Leemann T, Transon C, Dayer P: Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver. Life Sci. 1993;52(1):29-34. - Pubmed
DTHybrid score	1.003
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7559
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7702
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7144
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4105
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.3357
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.992
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.1063
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4271
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5272
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.32
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4803

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score	0.3295
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed
DTHybrid score	0.7429
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score	0.3366
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score	0.7228
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score	0.5069
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	inhibitor
References	Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.3003
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. - Pubmed
DTHybrid score	0.3749

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.3295
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.7429
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.3366
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.7228
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.5069
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions
References	Not Available
DTHybrid score	0.3003
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions
References	Not Available
DTHybrid score	0.3749

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.5748
4118	Cytochrome P450 3A5	CYP3A5	0.4035
5718	Cytochrome P450 2A6	CYP2A6	0.2827
6107	Cytochrome P450 3A7	CYP3A7	0.2757
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2683
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.2584
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.251
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.2483
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.2392
6143	Solute carrier family 22 member 7	SLC22A7	0.2156
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.2031
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1465
6145	Solute carrier family 22 member 1	SLC22A1	0.1439
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1394
6144	Solute carrier family 22 member 2	SLC22A2	0.1352
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.1327
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1313
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1313
1898	Cytochrome P450 1B1	CYP1B1	0.1218
118	Organic cation/carnitine transporter 2	SLC22A5	0.1152
776	Bile salt export pump	ABCB11	0.1126
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.1122
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.1067
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.1067
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.1015
6102	Arylamine N-acetyltransferase 2	NAT2	0.0989
3811	Cytochrome P450 19A1	CYP19A1	0.0936
6136	Multidrug resistance-associated protein 5	ABCC5	0.0935
492	Histamine H1 receptor	HRH1	0.0931
6141	Sodium/bile acid cotransporter	SLC10A1	0.0929
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0899
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0896
824	Sodium-dependent serotonin transporter	SLC6A4	0.0892
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0857
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0853
1757	Myeloperoxidase	MPO	0.0845
833	Organic cation/carnitine transporter 1	SLC22A4	0.0826
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0803
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.077
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0768
136	Estrogen receptor	ESR1	0.0754
817	DNA topoisomerase 2-alpha	TOP2A	0.0722
3923	Cholinesterase	BCHE	0.0708
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0705
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0702
6182	Cytochrome P450 2J2	CYP2J2	0.0699
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.069
556	Alpha-1A adrenergic receptor	ADRA1A	0.0685
738	Monocarboxylate transporter 1	SLC16A1	0.0674
6148	Multidrug resistance-associated protein 7	ABCC10	0.0666
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0664
6147	Solute carrier family 22 member 3	SLC22A3	0.0652
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0644
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0632
6137	Multidrug resistance-associated protein 6	ABCC6	0.0623
4604	Liver carboxylesterase 1	CES1	0.0616
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0612
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0609
468	Cytochrome P450 4A11	CYP4A11	0.0607
831	D(2) dopamine receptor	DRD2	0.0594
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0589
467	Delta-type opioid receptor	OPRD1	0.0573
146	Androgen receptor	AR	0.0559
847	Mu-type opioid receptor	OPRM1	0.0551
696	Kappa-type opioid receptor	OPRK1	0.055
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0548
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0548
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0548
708	Alpha-tocopherol transfer protein	TTPA	0.0548
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0548
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0545
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0545
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0542
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0542
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.054
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0539
2421	Signal peptidase I	lepB	0.0522
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0515
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0515
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.051
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0509
731	HIV-1 protease	HIV-1 protease	0.0508
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0497
320	5-hydroxytryptamine 1A receptor	HTR1A	0.049
723	Cytosolic phospholipase A2	PLA2G4A	0.0487
6500	Phospholipase A2	PLA2G1B	0.0485
758	Thyroid hormone receptor alpha	THRA	0.0484
318	Alpha-2A adrenergic receptor	ADRA2A	0.0484
871	Glucocorticoid receptor	NR3C1	0.0481
617	Muscarinic acetylcholine receptor M2	CHRM2	0.048
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0478
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0466
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0465
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0464
3941	Amine oxidase [flavin-containing] A	MAOA	0.0462
260	Cytochrome P450 51	ERG11	0.0445
761	Cytochrome P450 51	ERG11	0.0445
3163	Cytochrome P450 51	cyp51	0.0445
22	30S ribosomal protein S4	rpsD	0.0442
6714	30S ribosomal protein S4	rpsD	0.0442
6085	Fatty acid-binding protein, intestinal	FABP2	0.044
140	30S ribosomal protein S9	rpsI	0.044
6719	30S ribosomal protein S9	rpsI	0.044
6725	30S ribosomal protein S9	rpsI	0.044
891	Dihydropteroate synthase	folP	0.0439
5359	Dihydropteroate synthase	folP	0.0439
7175	Dihydropteroate synthase	sulI	0.0439
766	Beta-2 adrenergic receptor	ADRB2	0.0436
23	D(1A) dopamine receptor	DRD1	0.0436
274	Muscarinic acetylcholine receptor M5	CHRM5	0.043
703	NADPH azoreductase	azr	0.0427
346	Thyroid hormone receptor beta-1	THRB	0.0423
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.042
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0419
632	Alpha-1B adrenergic receptor	ADRA1B	0.0415
6149	Solute carrier family 22 member 10	SLC22A10	0.0405
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0405
465	Calmodulin	CALM1	0.0404
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0404
789	Alpha-1D adrenergic receptor	ADRA1D	0.0403
6167	Organic solute transporter subunit beta	OSTB	0.0398
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0398
6166	Organic solute transporter subunit alpha	OSTA	0.0397
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0397
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0394
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0392
404	DNA gyrase subunit A	gyrA	0.039
6224	DNA gyrase subunit A	gyrA	0.039
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.039
2344	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0389
3706	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0389
3677	Penicillin-insensitive murein endopeptidase precursor	mepA	0.0389
594	Thyroxine-binding globulin	SERPINA7	0.0388
777	Tumor necrosis factor	TNF	0.0388
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0383
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0383
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0383
1275	Estrogen sulfotransferase	SULT1E1	0.0382
6220	Aryl hydrocarbon receptor	AHR	0.0376
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0375
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0375
6031	Cytochrome P450 3A43	CYP3A43	0.0375
482	Glycine receptor subunit alpha-1	GLRA1	0.0368
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0367
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0365
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0365
3947	Xanthine dehydrogenase/oxidase	XDH	0.0364
6020	Aldehyde oxidase	AOX1	0.0359
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0358
6043	Putative G-protein coupled receptor 44	GPR44	0.0355
193	Beta-1 adrenergic receptor	ADRB1	0.0351
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.035
645	Penicillin-binding protein 1A	mrcA	0.0348
5805	Penicillin-binding protein 1A	ponA	0.0348
6185	Penicillin-binding protein 1A	mrcA	0.0348
6799	Penicillin-binding protein 1A	pbpA	0.0348
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0348
122	P2Y purinoceptor 12	P2RY12	0.0346
183	Vascular endothelial growth factor A	VEGFA	0.0343
70	Type-1 angiotensin II receptor	AGTR1	0.0342
504	Mast/stem cell growth factor receptor	KIT	0.0342
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0341
3810	Catechol O-methyltransferase	COMT	0.034
592	Carbonic anhydrase 4	CA4	0.034
3939	Amine oxidase [flavin-containing] B	MAOB	0.0338
869	Estrogen receptor beta	ESR2	0.0337
633	Penicillin-binding proteins 1A/1B	pbpA	0.0337
844	Epidermal growth factor receptor	EGFR	0.0336
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0335
295	Carbonic anhydrase 1	CA1	0.0335
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0333
713	Sodium-dependent dopamine transporter	SLC6A3	0.0332
33	Cystine/glutamate transporter	SLC7A11	0.0332
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0327
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0325
36	Insulin receptor	INSR	0.0325
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0324
543	Penicillin-binding protein 1B	mrcB	0.0321
6186	Penicillin-binding protein 1B	ponB	0.0321
6822	Penicillin-binding protein 1b	pbp1b	0.0321
6844	Penicillin-binding protein 1b	pbp1b	0.0321
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.032
477	DNA topoisomerase 4 subunit A	parC	0.0319
886	DNA topoisomerase 4 subunit A	parC	0.0319
6226	DNA topoisomerase 4 subunit A	parC	0.0319
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0317
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0314
558	Solute carrier family 12 member 1	SLC12A1	0.0314
811	Translocator protein	TSPO	0.0312
357	Carbonic anhydrase 2	CA2	0.0312
26	Vascular endothelial growth factor receptor 3	FLT4	0.031
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0309
1650	Heme carrier protein 1	SLC46A1	0.0309
756	Sex hormone-binding globulin	SHBG	0.0309
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0308
5626	Nucleoside diphosphate kinase B	NME2	0.0305
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0304
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.03
32	Vascular endothelial growth factor receptor 1	FLT1	0.0296
24	Thymidylate synthase	TMP1	0.0293
359	Thymidylate synthase	TYMS	0.0293
2626	Thymidylate synthase	thyA	0.0293
2729	Thymidylate synthase	thyA	0.0293
5352	Thymidylate synthase	THYA	0.0293
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0288
380	Cytochrome P450 17A1	CYP17A1	0.0287
1507	Cytochrome c	CYCS	0.0282
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0281
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0279
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0278
6014	Cytochrome P450 2A13	CYP2A13	0.0276
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0273
407	Vascular endothelial growth factor receptor 2	KDR	0.0273
578	Endothelin-1 receptor	EDNRA	0.0272
6126	Carbonic anhydrase 7	CA7	0.0268
6026	Alcohol dehydrogenase 6	ADH6	0.0266
1074	Urokinase-type plasminogen activator	PLAU	0.0265
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0265
124	Histamine H2 receptor	HRH2	0.0264
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0264
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0262
614	Progesterone receptor	PGR	0.0259
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0259
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0259
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0257
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0257
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0257
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0256
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0255
3932	Glutathione S-transferase A2	GSTA2	0.0253
6033	High affinity interleukin-8 receptor A	CXCR1	0.0252
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0252
273	Apoptosis regulator Bcl-2	BCL2	0.0252
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0251
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0249
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0248
438	Taste receptor type 1 member 2	TAS1R2	0.0248
5294	Nucleoside diphosphate kinase A	NME1	0.0246
3937	Fatty-acid amide hydrolase	FAAH	0.0238
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0238
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0238
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0238
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0236
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0235
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0235
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0235
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0235
6138	Multidrug resistance protein 3	ABCB4	0.0235
3426	Glutamine synthetase	glnA	0.0235
3987	Glutamine synthetase	GLUL	0.0235
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0234
672	Prostaglandin F2-alpha receptor	PTGFR	0.0234
130	Prostacyclin synthase	PTGIS	0.0233
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0233
952	Dipeptidyl peptidase 4	DPP4	0.0231
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0231
3917	Methylenetetrahydrofolate reductase	MTHFR	0.023
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0229
1	Peptidoglycan synthetase ftsI	ftsI	0.0229
4155	Peptidoglycan synthetase ftsI	ftsI	0.0229
338	DNA polymerase	UL30	0.0228
379	DNA polymerase	UL54	0.0228
697	DNA polymerase	ORF28	0.0228
2482	DNA polymerase	43	0.0228
4104	DNA polymerase	BALF5	0.0228
814	Ryanodine receptor 1	RYR1	0.0227
2021	Thrombomodulin	THBD	0.0226
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0225
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0225
638	D(3) dopamine receptor	DRD3	0.0223
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0222
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
1618	High affinity nerve growth factor receptor	NTRK1	0.0219
1648	Elastin	ELN	0.0217
6042	Prostaglandin reductase 2	PTGR2	0.0217
3312	Fatty acid-binding protein, brain	FABP7	0.0217
4165	P2Y purinoceptor 2	P2RY2	0.0216
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0216
199	Monocarboxylate transporter 8	SLC16A2	0.0215
65	Matrix metalloproteinase-9	Not Available	0.0214
6131	Carbonic anhydrase 14	CA14	0.0214
161	Tubulin beta chain	TUBB	0.0213
312	Tubulin beta chain	TUB2	0.0213
115	Penicillin-binding protein 2	mrdA	0.0213
6069	Penicillin-binding protein 2	mrdA	0.0213
6118	Penicillin-binding protein 2	penA	0.0213
6187	Penicillin-binding protein 2	pbpA	0.0213
6686	Penicillin-binding protein 2	pbp2	0.0213
6939	Penicillin-binding protein 2	mrdA	0.0213
7163	Penicillin-binding protein 2	pbpA	0.0213
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.021
4120	NADPH--cytochrome P450 reductase	POR	0.021
904	Glutathione S-transferase P	GSTP1	0.0209
1192	Sulfotransferase 1A1	SULT1A1	0.0207
853	Farnesyl pyrophosphate synthetase	FDPS	0.0205
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0205
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0203
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0202
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
16	Adenosine A1 receptor	ADORA1	0.02
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0199
629	Alpha-2B adrenergic receptor	ADRA2B	0.0199
29	Tubulin beta-1 chain	TUBB1	0.0199
54	Prothrombin	F2	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0198
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0197
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0196
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0196
1050	Bile salt sulfotransferase	SULT2A1	0.0194
563	Thyroid peroxidase	TPO	0.0194
705	Glutamate receptor 1	GRIA1	0.0194
1654	Interleukin-1 beta	IL1B	0.0192
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0192
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0192
2320	Thymidine kinase, cytosolic	TK1	0.0192
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0191
6258	Protein S100-A7	S100A7	0.0191
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0191
293	Gamma-glutamyl hydrolase	GGH	0.019
365	Dihydrofolate reductase	DHFR	0.019
2381	Dihydrofolate reductase	DFR1	0.019
2833	Dihydrofolate reductase	Not Available	0.019
2931	Dihydrofolate reductase	folA	0.019
3544	Dihydrofolate reductase	folA	0.019
3682	Dihydrofolate reductase	folA	0.019
6642	Dihydrofolate reductase	folA	0.019
6756	Dihydrofolate reductase	dfrA	0.019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.019
1010	Cytochrome P450 51A1	CYP51A1	0.019
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0188
1405	Thiopurine S-methyltransferase	TPMT	0.0187
1159	Interleukin-6	IL6	0.0185
4217	Telomerase reverse transcriptase	TERT	0.0184
1313	Lactoylglutathione lyase	GLO1	0.0184
1656	CYP2B protein	CYP2B	0.0184
6122	Carbonic anhydrase 3	CA3	0.0183
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0183
5353	Glutamate decarboxylase alpha	gadA	0.0183
489	Monocarboxylate transporter 2	SLC16A7	0.0182
459	Retinoic acid receptor RXR-alpha	RXRA	0.0181
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.018
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.018
3809	Estrogen-related receptor gamma	ESRRG	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
4122	Histone deacetylase 2	HDAC2	0.0179
5880	Thrombopoietin receptor	MPL	0.0178
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0178
319	Opioid receptor, sigma 1	OPRS1	0.0177
823	Fibroblast growth factor receptor 2	FGFR2	0.0176
1178	Adenosine A2a receptor	ADORA2A	0.0174
2654	Complement control protein	C3L	0.0174
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0174
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0173
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0172
1867	Major prion protein	PRNP	0.0171
3233	Bile acid receptor	NR1H4	0.0171
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0171
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.017
378	Alpha-2C adrenergic receptor	ADRA2C	0.017
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0168
185	Vasopressin V1a receptor	AVPR1A	0.0167
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0167
1198	Serum paraoxonase/arylesterase 1	PON1	0.0167
6223	Penicillin-binding protein 1C	pbpC	0.0167
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0166
2449	Tubulin alpha-3 chain	TUBA1A	0.0166
3639	Thymidine phosphorylase	deoA	0.0164
3936	Thymidine phosphorylase	TYMP	0.0164
430	Follicle-stimulating hormone receptor	FSHR	0.0164
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0164
3007	Carbonic anhydrase 12	CA12	0.0164
4205	Carbonic anhydrase 9	CA9	0.0164
322	Vasopressin V2 receptor	AVPR2	0.0163
6218	Pannexin-1	PANX1	0.0163
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0163
818	50S ribosomal protein L10	rplJ	0.016
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0159
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
494	Caspase-1	CASP1	0.0158
2236	Casein kinase II subunit alpha	CSNK2A1	0.0157
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0157
1792	Tissue-type plasminogen activator	PLAT	0.0156
85	Growth hormone receptor	GHR	0.0156
6151	Monocarboxylate transporter 10	SLC16A10	0.0156
908	Glutathione S-transferase theta-1	GSTT1	0.0155
737	Mineralocorticoid receptor	NR3C2	0.0155
921	Glutamate receptor 2	GRIA2	0.0153
571	Melatonin receptor type 1A	MTNR1A	0.0152
362	Melatonin receptor type 1B	MTNR1B	0.0152
5455	Arylsulfatase A	ARSA	0.0151
1714	Mitogen-activated protein kinase 3	MAPK3	0.0151
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6207	30S ribosomal protein S14	rpsN	0.0148
6209	30S ribosomal protein S19	rpsS	0.0148
6712	30S ribosomal protein S19	rpsS	0.0148
6726	30S ribosomal protein S19	rpsS	0.0148
527	Prostacyclin receptor	PTGIR	0.0147
427	Substance-P receptor	TACR1	0.0147
3808	Dihydropteroate synthase 2	folP2	0.0145
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0145
244	Angiotensin-converting enzyme	ACE	0.0145
3601	Dihydropteroate synthase 1	folP1	0.0145
3807	Dihydropteroate synthase 1	folP1	0.0145
2499	Tubulin beta-2C chain	TUBB2C	0.0144
117	Sterol O-acyltransferase 1	SOAT1	0.0143
716	5-hydroxytryptamine 7 receptor	HTR7	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
1517	Beta-3 adrenergic receptor	ADRB3	0.0141
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.014
4192	DNA topoisomerase 2-beta	TOP2B	0.014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0139
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0139
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0136
6135	Sodium channel subunit beta-4	SCN4B	0.0136
6134	Sodium channel subunit beta-3	SCN3B	0.0136
6133	Sodium channel subunit beta-2	SCN2B	0.0136
6132	Sodium channel subunit beta-1	SCN1B	0.0136
6127	Carbonic anhydrase-related protein	CA8	0.0135
6129	Carbonic anhydrase-related protein 11	CA11	0.0135
6128	Carbonic anhydrase-related protein 10	CA10	0.0135
432	D(4) dopamine receptor	DRD4	0.0135
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0134
3587	Gastrotropin	FABP6	0.0134
1629	Transcription factor AP-1	JUN	0.0134
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0133
992	Protein tyrosine kinase 2 beta	PTK2B	0.0133
2077	Caspase-3	CASP3	0.0132
520	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	murA	0.0132
2306	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	murA	0.0132
2367	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	murA	0.0132
4116	Dihydropteroate synthetase	Not Available	0.0131
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0131
232	Corticosteroid-binding globulin	SERPINA6	0.013
94	5-hydroxytryptamine 4 receptor	HTR4	0.013
3307	Acriflavine resistance protein B	acrB	0.013
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0129
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
5818	Folate receptor alpha	FOLR1	0.0128
165	FL cytokine receptor	FLT3	0.0128
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0128
88	Retinoic acid receptor RXR-beta	RXRB	0.0128
1353	DNA topoisomerase 1	TOP1	0.0128
3552	DNA topoisomerase 1	topA	0.0128
1630	Integrin beta-2	ITGB2	0.0127
3685	Catabolite gene activator	crp	0.0126
4655	Adenylate cyclase	cyaC	0.0126
4759	Adenylate cyclase	cyaB2	0.0126
634	Squalene monooxygenase	SQLE	0.0126
7196	Squalene monooxygenase	ERG1	0.0126
6432	Transporter	snf	0.0125
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
5787	Angiopoietin-1 receptor	TEK	0.0124
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0124
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0121
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.012
6044	Serum paraoxonase/lactonase 3	PON3	0.012
1039	Histone deacetylase 9	HDAC9	0.012
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0118
6174	50S ribosomal protein L32	rpmF	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
7	Nitric oxide synthase, inducible	NOS2	0.0117
780	Retinoic acid receptor RXR-gamma	RXRG	0.0117
6146	High affinity copper uptake protein 1	SLC31A1	0.0116
997	Protein kinase C beta type	PRKCB	0.0116
48	Pyridoxal kinase	PDXK	0.0116
1760	Aminopeptidase N	ANPEP	0.0116
6843	Aminopeptidase N	pepN	0.0116
68	Cannabinoid receptor 1	CNR1	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0113
174	Sigma 1-type opioid receptor	SIGMAR1	0.0113
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0113
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0113
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0112
2249	Aspartate aminotransferase	aspC	0.0112
2671	Aspartate aminotransferase	aspC	0.0112
5490	Aspartate aminotransferase	Not Available	0.0112
84	Nuclear receptor 0B1	NR0B1	0.0112
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0112
3823	Cytokine receptor common gamma chain	IL2RG	0.0112
663	Solute carrier family 12 member 4	SLC12A4	0.0111
53	Solute carrier family 12 member 5	SLC12A5	0.0111
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
6130	Carbonic anhydrase 13	CA13	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0109
284	DNA-directed RNA polymerase beta chain	rpoB	0.0108
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0108
1970	Protein kinase C alpha type	PRKCA	0.0108
4760	Mll3241 protein	mll3241	0.0107
4237	50S ribosomal protein L22	rplV	0.0107
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0107
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0107
3957	Adenosine deaminase	ADA	0.0107
518	Peroxidase/catalase T	katG	0.0106
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0105
310	Solute carrier family 12 member 2	SLC12A2	0.0104
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0104
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0104
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0103
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0103
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0102
162	Retinoic acid receptor gamma-1	RARG	0.0101
5482	Sialidase-2	NEU2	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
461	Glycine receptor subunit alpha-3	GLRA3	0.01
474	Acetylcholinesterase	ACHE	0.01
267	Plasminogen activator inhibitor 1	SERPINE1	0.01
2539	Tubulin alpha-1 chain	TUBA4A	0.0099
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0099
4221	Vascular endothelial growth factor	VEGF	0.0099
5816	Cadherin-5	CDH5	0.0099
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0099
3760	Penicillin-binding protein 5 precursor	dacA	0.0098
1439	Lactotransferrin	LTF	0.0098
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0098
724	Interleukin-2 receptor alpha chain	IL2RA	0.0097
717	Interleukin-2 receptor subunit beta	IL2RB	0.0097
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0097
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0097
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0097
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0096
819	Penicillin-binding protein 4	dacB	0.0096
517	Alcohol dehydrogenase 1C	ADH1C	0.0096
4238	50S ribosomal protein L4	rplD	0.0096
5578	50S ribosomal protein L4	rplD	0.0096
6173	50S ribosomal protein L4	rplD	0.0096
6219	50S ribosomal protein L4	rplD	0.0096
49	Endothelin B receptor	EDNRB	0.0096
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0096
4203	Histamine N-methyltransferase	HNMT	0.0095
4773	Deoxycytidine kinase	DCK	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
566	Serotransferrin	TF	0.0094
283	SEC14-like protein 2	SEC14L2	0.0094
820	Glycine receptor subunit alpha-2	GLRA2	0.0094
867	Penicillin-binding protein 3	pbpC	0.0094
6119	Penicillin-binding protein 3	pbp3	0.0094
7154	Penicillin-binding protein 3	pbp3	0.0094
7157	Penicillin-binding protein 3	LMHCC_2184	0.0094
7162	Penicillin-binding protein 3	pbpB	0.0094
7172	Penicillin-binding protein 3	pbp3	0.0094
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
1852	Microtubule-associated protein 2	MAP2	0.0093
4103	Proteasome subunit beta type 2	PSMB2	0.0092
4102	Proteasome subunit beta type 5	PSMB5	0.0092
4101	Proteasome subunit beta type 1	PSMB1	0.0092
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0092
444	Alcohol dehydrogenase 1B	ADH1B	0.0092
251	Alcohol dehydrogenase 1A	ADH1A	0.0092
106	Cannabinoid receptor 2	CNR2	0.0091
6221	Steroid hormone receptor ERR1	ESRRA	0.0091
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0091
718	Folate receptor gamma	FOLR3	0.009
299	Folate receptor beta	FOLR2	0.009
804	Mitochondrial folate transporter/carrier	SLC25A32	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
291	Nitric-oxide synthase, endothelial	NOS3	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0088
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0088
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0088
6103	Arylamine N-acetyltransferase 1	NAT1	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
4311	tRNA	TRDMT1	0.0087
4325	tRNA	trmD	0.0087
4328	tRNA	trmD	0.0087
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
572	Integrin alpha-L	ITGAL	0.0086
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0085
822	Aldose reductase	AKR1B1	0.0084
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0084
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0083
1992	Vitamin D-binding protein	GC	0.0083
905	Glutathione transferase omega-1	GSTO1	0.0083
899	Glutathione S-transferase Mu 3	GSTM3	0.0082
3856	Fibroblast growth factor receptor 3	FGFR3	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
163	D(1B) dopamine receptor	DRD5	0.0081
564	Cellular retinoic acid-binding protein 1	CRABP1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0079
856	Vitamin D3 receptor	VDR	0.0079
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
569	Retinal dehydrogenase 2	ALDH1A2	0.0079
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0079
936	Ephrin type-A receptor 2	EPHA2	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
719	Retinoic acid receptor responder protein 1	RARRES1	0.0077
770	Retinoic acid-induced protein 3	GPRC5A	0.0077
581	Cytochrome P450 2R1	CYP2R1	0.0077
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0077
6228	Nuclear receptor coactivator 1	NCOA1	0.0077
239	Coagulation factor X	F10	0.0077
5934	Cytochrome P450 26A1	CYP26A1	0.0077
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0077
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0077
2230	Catalase	CAT	0.0076
3249	Catalase	katA	0.0076
3625	Catalase	katA	0.0076
4539	Catalase	katA	0.0076
4941	Catalase	katB	0.0076
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0076
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0075
86	SEC14-like protein 4	SEC14L4	0.0075
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0075
375	SEC14-like protein 3	SEC14L3	0.0075
4076	Diacylglycerol kinase alpha	DGKA	0.0075
702	UMP-CMP kinase	CMPK1	0.0075
1541	Metalloproteinase	mmp20	0.0074
611	Retinal dehydrogenase 1	ALDH1A1	0.0074
976	Platelet glycoprotein IX	GP9	0.0074
5923	Microtubule-associated protein tau	MAPT	0.0074
5924	Microtubule-associated protein 4	MAP4	0.0074
4228	Keratin, type II cytoskeletal 7	KRT7	0.0074
6241	Nuclear receptor coactivator 2	NCOA2	0.0073
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0073
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0071
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0071
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
5300	Antigen peptide transporter 1	TAP1	0.0071
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0071
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
1374	Natriuretic peptides B	NPPB	0.007
1827	Gap junction alpha-1 protein	GJA1	0.007
1908	Vascular cell adhesion protein 1	VCAM1	0.007
828	Phenylalanine-4-hydroxylase	PAH	0.0069
3109	Phenylalanine-4-hydroxylase	phhA	0.0069
810	Heme oxygenase 1	HMOX1	0.0069
3391	Heme oxygenase 1	pbsA1	0.0069
153	Dopamine beta-hydroxylase	DBH	0.0068
4226	Uridine phosphorylase 2	UPP2	0.0067
661	ADP/ATP translocase 1	SLC25A4	0.0067
896	Glutathione S-transferase Mu 1	GSTM1	0.0067
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0065
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0065
1196	Complement decay-accelerating factor	CD55	0.0065
3830	Calreticulin	CALR	0.0065
469	Annexin A1	ANXA1	0.0065
5798	Mitogen-activated protein kinase 11	MAPK11	0.0065
2112	Toll-like receptor 9	TLR9	0.0064
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
751	Potassium channel subfamily K member 6	KCNK6	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
2207	Rhodopsin	RHO	0.0063
768	FK506-binding protein 1A	FKBP1A	0.0062
4225	Uridine phosphorylase 1	UPP1	0.0062
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0061
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0061
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0061
6034	Hydroxyindole O-methyltransferase	ASMT	0.006
6035	Nuclear receptor ROR-beta	RORB	0.006
6036	Eosinophil peroxidase	EPX	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0059
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0059
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
172	Potassium channel subfamily K member 1	KCNK1	0.0058
2408	Tyrosine-protein kinase SYK	SYK	0.0058
4692	A/G-specific adenine glycosylase	mutY	0.0058
413	Amidophosphoribosyltransferase	PPAT	0.0058
2515	Amidophosphoribosyltransferase	purF	0.0058
3714	Amidophosphoribosyltransferase	purF	0.0058
229	Retinoic acid receptor beta	RARB	0.0058
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0058
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
707	72 kDa type IV collagenase	MMP2	0.0057
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0057
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0057
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0057
2808	Chloramphenicol acetyltransferase 3	cat3	0.0057
730	Retinoic acid receptor alpha	RARA	0.0057
714	Glutathione reductase, mitochondrial	GSR	0.0057
1483	Membrane copper amine oxidase	AOC3	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
6163	Copper-transporting ATPase 2	ATP7B	0.0055
6165	Copper-transporting ATPase 1	ATP7A	0.0055
6501	Fatty acid-binding protein, liver	FABP1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
4252	Penicillin-binding protein 5	dacA	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
765	Indoleamine 2,3-dioxygenase	IDO1	0.0053
159	Penicillin-binding protein 2B	penA	0.0052
6121	Penicillin-binding protein 2B	penA	0.0052
2417	Chloramphenicol acetyltransferase	cat	0.0052
3278	Chloramphenicol acetyltransferase	cat	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0052
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0052
2810	Dr hemagglutinin structural subunit	draA	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
132	ATP-binding cassette sub-family A member 1	ABCA1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
2599	Tyrosine-protein kinase HCK	HCK	0.005
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
268	Adenosine A2b receptor	ADORA2B	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
6168	Solute carrier family 22 member 16	SLC22A16	0.0049
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0048
4210	Toll-like receptor 4	TLR4	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0048
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0047
6677	Myelin P2 protein	PMP2	0.0047
4943	Cytochrome c6	petJ	0.0047
4954	Soluble cytochrome b558	Not Available	0.0047
4934	Cytochrome c-551	nirM	0.0047
5218	Cytochrome c-551	nirM	0.0047
4905	Cytochrome c2	Not Available	0.0047
4939	Cytochrome c2	cycA	0.0047
4964	Cytochrome c2	cycA	0.0047
4979	Cytochrome c2	cycA	0.0047
6673	Cytochrome c2	cycA	0.0047
4947	Bacterial hemoglobin	vhb	0.0047
4916	Cyanoglobin	glbN	0.0047
4994	Hemoglobin-like protein HbO	glbO	0.0047
4925	Cytochrome c-type protein SHP	shp	0.0047
4975	Cytochrome c-556	RPA3973	0.0047
4915	Cytochrome c-550	psbV	0.0047
4959	Cytochrome c-550	psbV	0.0047
5216	Cytochrome c-550	psbV	0.0047
4984	Neuroglobin	NGB	0.0047
4942	Diheme cytochrome c napB	napB	0.0047
4998	Hemoglobin-like protein yjbI	yjbI	0.0047
4909	CooA protein	cooA	0.0047
4936	Cytochrome c2 iso-2	Not Available	0.0047
4907	Cytochrome c-L	moxG	0.0047
6865	Cytochrome c-L	moxG	0.0047
4981	Iron-starvation protein PigA	pigA	0.0047
5000	HemO	hemO	0.0047
644	Heme oxygenase 2	HMOX2	0.0047
4982	Heme oxygenase 2	pbsA2	0.0047
4935	Cytochrome c-554	cycA1	0.0047
4961	Hemophore HasA	hasA	0.0047
4910	Cytoglobin	CYGB	0.0047
4989	Cytochrome c551 peroxidase	ccp	0.0047
5222	Cytochrome c551 peroxidase	ccpA	0.0047
4971	Nonaheme cytochrome c	hmcA	0.0047
4904	Cytochrome c family protein	GSU1996	0.0047
4764	Cytochrome P450 165C4	CYP165C4	0.0047
4976	Apocytochrome f	petA	0.0047
6407	Apocytochrome f	petA	0.0047
4999	Cytochrome P450 165B3	CYP165B3	0.0047
4937	Cytochrome oxidase subunit II	rcoxA	0.0047
4931	Cytochrome P450 167A1	CYP167A1	0.0047
4960	Putative cytochrome P450-family protein	SCO7417	0.0047
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0047
4903	Methyl-accepting chemotaxis protein	Tar4	0.0047
4972	P450cin	cinA	0.0047
4993	Hydroxylamine oxidoreductase	hao1	0.0047
4922	Cytochrome c, putative	SO_4144	0.0047
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0047
4952	Catalase/peroxidase	katA	0.0047
3093	Catalase HPII	katE	0.0047
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0047
358	Cystathionine beta-synthase	CBS	0.0047
2391	Ferrochelatase	hemH	0.0047
6502	Ferrochelatase	DKFZp686P18130	0.0047
1591	Ferrochelatase, mitochondrial	FECH	0.0047
683	Potassium transporter	GK0582	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
1253	Interferon gamma	IFNG	0.0046
173	Toll-like receptor 7	TLR7	0.0046
2298	Cytochrome P450-cam	camC	0.0045
1291	cAMP response element-binding protein	CREB1	0.0045
1864	RET proto-oncogene	RET	0.0045
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0045
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0045
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
3221	Cytochrome c4	cc4	0.0045
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0044
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0044
760	Fibroblast growth factor 1	FGF1	0.0044
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0042
6837	Serine/threonine-protein kinase 17B	STK17B	0.0042
164	Histamine H4 receptor	HRH4	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0042
6459	Glycodelin	PAEP	0.0041
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0041
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0041
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0041
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0041
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0041
408	Riboflavin kinase	RFK	0.0041
2300	Lysozyme	E	0.0041
3633	Lysozyme	R	0.0041
5597	Lysozyme	17	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0041
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0041
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0041
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0041
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0041
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0041
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0041
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0041
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0041
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0041
6559	Cytochrome c oxidase subunit 2	ctaC	0.0041
6669	Cytochrome c oxidase subunit 2	ctaC	0.0041
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.004
371	Cytochrome c oxidase subunit 1	MT-CO1	0.004
6558	Cytochrome c oxidase subunit 1	ctaD	0.004
3679	MTA/SAH nucleosidase	mtnN	0.004
4948	Cytochrome c-553	Not Available	0.004
4923	Cytochrome c3	DvMF_2499	0.004
4945	Cytochrome c3	Not Available	0.004
4949	Cytochrome c3	DVU_3171	0.004
4968	Cytochrome c3	cytc3	0.004
4997	Cytochrome c3	SO_2727	0.004
5219	Cytochrome c3	cyd	0.004
4902	Nine-heme cytochrome c	Ddes_2038	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
3189	High-molecular-weight cytochrome c	hmcA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
3913	Glutamic acid decarboxylase	GAD65	0.004
4161	Furin	FURIN	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
131	Synaptic vesicular amine transporter	SLC18A2	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0038
76	Nitric-oxide synthase, brain	NOS1	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
2540	Choloylglycine hydrolase	cbh	0.0037
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0037
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
3404	Exotoxin A	eta	0.0036
4920	Peroxidase/catalase	katG	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
4386	Hemoglobin-like protein HbN	glbN	0.0035
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0034
2119	Cytochrome b5	CYB5A	0.0034
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0034
1268	Neuropeptide S receptor	NPSR1	0.0034
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0034
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0034
4990	PpcA	ppcA	0.0034
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
3570	Cytochrome P450 152A1	cypC	0.0034
4988	Sulfite oxidase, mitochondrial	SUOX	0.0034
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0034
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0034
4289	Cytochrome P450	TT_P0059	0.0034
6262	Cytochrome P450	staP	0.0034
4992	Cytochrome c peroxidase	Not Available	0.0034
2915	Sensor protein fixL	fixL	0.0034
4944	Sensor protein fixL	fixL	0.0034
3375	Acidic cytochrome c3	Not Available	0.0034
4385	Cytochrome c'	Not Available	0.0034
4967	Cytochrome c'	cycA	0.0034
5038	Cytochrome c'	Not Available	0.0034
5223	Cytochrome c'	cycP	0.0034
4813	Heme oxygenase	hmuO	0.0034
5769	Heme oxygenase	Not Available	0.0034
735	Alanine aminotransferase 1	GPT	0.0033
3904	Alanine aminotransferase 2	GPT2	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0032
331	Retinol-binding protein I, cellular	RBP1	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
6073	Potassium channel subfamily K member 9	KCNK9	0.0031
6072	Potassium channel subfamily K member 3	KCNK3	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
484	Tyrosine-protein kinase ABL2	ABL2	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.003
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.003
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
3670	Soluble cytochrome b562 precursor	cybC	0.003
3411	Cytochrome P450 121	cyp121	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.003
2617	Nitric oxide synthase oxygenase	nos	0.003
2701	Nitric oxide synthase oxygenase	nos	0.003
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.003
3291	Cytochrome c-552	cycA	0.003
4927	Cytochrome c-552	nrfA	0.003
4938	Cytochrome c-552	cycA	0.003
4953	Cytochrome c-552	nrfA	0.003
5217	Cytochrome c-552	cycM	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3102	Flavohemoprotein	hmp	0.0029
4969	Flavohemoprotein	hmp	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0029
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
4041	Microsomal glutathione S-transferase 2	MGST2	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0027
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0027
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0027
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6859	Protein S100-A4	S100A4	0.0025
4608	Putative cytochrome P450	SCO1207	0.0025
4963	Putative cytochrome P450	SCO2884	0.0025
6254	Putative cytochrome P450	SCO6998	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
798	Osteocalcin	BGLAP	0.0025
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
4031	Glutathione S-transferase A1	GSTA1	0.0023
369	Coagulation factor VII	F7	0.0023
693	Hemoglobin subunit beta	HBB	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
4034	Glutaredoxin-1	GLRX	0.0022
1928	Leukotriene C4 synthase	LTC4S	0.0022
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0022
910	Epididymal secretory glutathione peroxidase	GPX5	0.0022
4036	Glutathione peroxidase 6	GPX6	0.0022
4037	Hypothetical protein	GPX1	0.0022
4297	Hypothetical protein	SP_1951	0.0022
4521	Hypothetical protein	BC_2969	0.0022
4540	Hypothetical protein	TM_1070	0.0022
4555	Hypothetical protein	MT1739	0.0022
4569	Hypothetical protein	mshD	0.0022
4578	Hypothetical protein	PA3270	0.0022
4747	Hypothetical protein	PA3967	0.0022
5177	Hypothetical protein	TM_0096	0.0022
5194	Hypothetical protein	PA1204	0.0022
5240	Hypothetical protein	Rv2991	0.0022
5370	Hypothetical protein	TM_1158	0.0022
5710	Hypothetical protein	Tb927.5.1360	0.0022
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0022
4029	Microsomal glutathione S-transferase 3	MGST3	0.0022
911	Glutathione peroxidase 3	GPX3	0.0022
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0022
903	Glutathione S-transferase A5	GSTA5	0.0022
4032	Microsomal glutathione S-transferase 1	MGST1	0.0022
4040	Glutathione peroxidase 7	GPX7	0.0022
907	Glutathione peroxidase 2	GPX2	0.0022
900	Glutathione S-transferase A4	GSTA4	0.0022
906	Glutathione peroxidase 1	GPX1	0.0022
4035	Glutathione S-transferase Mu 5	GSTM5	0.0022
4042	Glutathione transferase omega-2	GSTO2	0.0022
4033	S-formylglutathione hydrolase	ESD	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
4038	Glutathione peroxidase 4	GPX4	0.0022
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0022
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
6268	Hydroxyacid oxidase 1	HAO1	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
2091	Endoplasmin	HSP90B1	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
3319	Hydroxyacylglutathione hydrolase	HAGH	0.002
897	Glutathione S-transferase kappa 1	GSTK1	0.002
898	Glutathione S-transferase A3	GSTA3	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
909	Maleylacetoacetate isomerase	GSTZ1	0.002
6755	Poliovirus receptor	PVR	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
1243	Cathepsin D	CTSD	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
2165	Glutathione S-transferase Mu 2	GSTM2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
207	Glutathione synthetase	GSS	0.0017
5269	Glutathione synthetase	gshB	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
901	Glutathione S-transferase Mu 4	GSTM4	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
6316	ADP-ribosylation factor 1	ARF1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
2802	Endoglucanase G	celCCG	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
1295	Fatty acid synthase	FASN	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
345	Plasma retinol-binding protein	RBP4	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
1184	Interferon beta	IFNB1	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2430	Chondroitinase B	cslB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
6021	Adenosine kinase	ADK	0.0002
2440	Endoglucanase F	celCCF	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00586 - Diclofenac

Targets

Enzymes

Transporters

Carriers

Predictions