DT-Web

DB01381 - Ginkgo biloba


Identification
Name Ginkgo biloba
Accession Number DB01381
Type small molecule
Description The extract of the Ginkgo leaves contains flavonoid glycosides and terpenoids (ginkgolides, bilobalides) and has been used pharmaceutically for hundreds of years. It has many alleged nootropic properties, and is mainly used as memory and concentration enhancer, and anti-vertigo agent. Ginkgo extract seems to have three effects on the human body: it improves blood flow (including microcirculation in small capillaries) to most tissues and organs; it protects against oxidative cell damage from free radicals; and it blocks many of the effects of PAF (platelet aggregation, blood clotting) that have been related to the development of a number of cardiovascular, renal, respiratory and CNS (Central Nervous System) disorders.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Appears to be effective in: alleviating age-related memory impairment in some elderly people with mild to moderate age-related memory or cognitive impairment; improving cognitive function in healthy young to middle-aged people; improving symptoms of Alzheimer's, vascular or mixed dementia; improving damage to the visual field in patients with normal tension glaucoma; decreasing the number of painful attacks in patients with Raynaud's syndrome; and may improve symptoms of vertigo and dizziness in some patients.
Mechanism of action The compounds found in ginkgo may have a protective role in different stages of the decline of intellectual function via several mechanisms of action: vasoregulating activity of arteries, capillaries, and veins (increased blood flow); platelet activating factor (PAF) antagonism; homeostasis of inflammation and oxidative stress; and prevention of cell membrane damage causedby free radicals; and neurotransmission modulation. The most important substances are flavonoids (ginkgo flavone glycosides) and terpenoids (ginkgolides and bilobalide).The compounds inginkgo act to varying degrees as scavengers for free radicals.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Fresh seeds are toxic may cause death. Roasted seed and crude ginkgo plant should not be used orally. Consumption of greater than 10 roasted seeds may cause difficulty breathing, weak pulse, seizures, loss of consciousness, and shock. Standardized ginkgo leaf extracts have been used safely in trials lasting several weeks to six years; however, cases of spontaneous hemorrhages have been reported with the conventional use of the standardized extract. As with all medications, individual risk factors must be considered in the assessment of safety of this medication. This medication is well-tolerated at standard oral doses. Ginkgo biloba may cause gastrointestinal upset, headache, dizziness, palpitations, nausea, vomiting, lack of muscle tone and weakness.
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Abciximab Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Acenocoumarol Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Acetylsalicylic acid Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Alteplase Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Anagrelide Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Argatroban Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Bivalirudin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Cilostazol Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Citalopram Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Clopidogrel Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Dabigatran etexilate Additive anticoagulant/antiplatelet effects of gingko may increase bleed risk for patients on dabigatran. Concomitant therapy should be avoided.
Diclofenac Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Diflunisal Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Dipyridamole Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Enoxaparin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Eptifibatide Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Escitalopram Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Etodolac Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Fenoprofen Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Fluoxetine Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Flurbiprofen Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Fluvoxamine Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Fondaparinux sodium Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Ginseng Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Heparin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Ibuprofen Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Indomethacin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Ketoprofen Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Ketorolac Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Lepirudin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Meclofenamic acid Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Meloxicam Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Nabumetone Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Naproxen Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Oxaprozin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Paroxetine Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Piroxicam Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Prasugrel Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Reteplase Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Rivaroxaban Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
S-Adenosylmethionine Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Sertraline Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Sulindac Ginkgo biloba may enhance the anticoagulant effect of sulindac. Increased risk of bleeding, bruising and altered mental status due to CNS bleeds. Concomitant therapy should be avoided.
Tacrine Ginkgo biloba may cause additive/toxic cholinergic effects when administered with Tacrine. Monitor for cholinergic toxicity.
Tenecteplase Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Tiaprofenic acid Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Ticlopidine Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Tirofiban Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Tolmetin Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Trazodone Increased effect and toxicity of both agents
Urokinase Increased risk of bleeding.
Warfarin Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Food Interactions Not Available

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions inhibitor
References
  • Fehske CJ, Leuner K, Muller WE: Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacol Res. 2009 Jul;60(1):68-73. Epub 2009 Mar 21. - Pubmed
DTHybrid score 0.3562
Phospholipase A2, membrane associated
Name Phospholipase A2, membrane associated
Gene Name PLA2G2A
Pharmacological action unknown
Actions inhibitor
References
  • Kim HK, Son KH, Chang HW, Kang SS, Kim HP: Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves. Planta Med. 1999 Jun;65(5):465-7. - Pubmed
  • Weichel O, Hilgert M, Chatterjee SS, Lehr M, Klein J: Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):609-15. - Pubmed
  • Lim H, Son KH, Chang HW, Kang SS, Kim HP: Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol Pharm Bull. 2006 May;29(5):1046-9. - Pubmed
DTHybrid score 1.1253
Glycine receptor subunit alpha-1
Name Glycine receptor subunit alpha-1
Gene Name GLRA1
Pharmacological action unknown
Actions antagonist
References
  • Heads JA, Hawthorne RL, Lynagh T, Lynch JW: Structure-activity analysis of ginkgolide binding in the glycine receptor pore. J Neurochem. 2008 May;105(4):1418-27. Epub 2008 Jan 21. - Pubmed
DTHybrid score 0.2156
Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action unknown
Actions negative modulator
References
  • Hanrahan JR, Chebib M, Davucheron NL, Hall BJ, Johnston GA: Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. - Pubmed
DTHybrid score 0.3788
Gamma-aminobutyric-acid receptor subunit beta-2
Name Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name GABRB2
Pharmacological action unknown
Actions negative modulator
References
  • Hanrahan JR, Chebib M, Davucheron NL, Hall BJ, Johnston GA: Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. - Pubmed
DTHybrid score 0.2269
Gamma-aminobutyric acid receptor subunit gamma-2
Name Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name GABRG2
Pharmacological action unknown
Actions negative modulator
References
  • Hanrahan JR, Chebib M, Davucheron NL, Hall BJ, Johnston GA: Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. - Pubmed
DTHybrid score 0.2383

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Yale SH, Glurich I: Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med. 2005 Jun;11(3):433-9. - Pubmed
  • Greenblatt DJ, von Moltke LL, Luo Y, Perloff ES, Horan KA, Bruce A, Reynolds RC, Harmatz JS, Avula B, Khan IA, Goldman P: Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate. J Clin Pharmacol. 2006 Feb;46(2):214-21. - Pubmed
DTHybrid score 0.2624

Predictions


Id Partner name Gene Name Score
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.1878
4512 Cytochrome P450 3A4 CYP3A4 0.1846
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.1714
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.171
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1686
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.1675
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.153
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1507
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1476
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1472
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.147
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1469
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1469
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1468
4119 Cytochrome P450 2D6 CYP2D6 0.1297
6016 Cytochrome P450 2C19 CYP2C19 0.1281
824 Sodium-dependent serotonin transporter SLC6A4 0.1271
713 Sodium-dependent dopamine transporter SLC6A3 0.1089
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.1083
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.1039
6013 Cytochrome P450 2E1 CYP2E1 0.0969
6030 Cytochrome P450 2B6 CYP2B6 0.0923
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0917
4924 Cytochrome P450 2C8 CYP2C8 0.0847
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0829
4200 Cytochrome P450 1A2 CYP1A2 0.0828
537 ATP synthase delta chain, mitochondrial ATP5D 0.0812
587 Serum albumin ALB 0.0772
705 Glutamate receptor 1 GRIA1 0.0747
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0745
1588 Multidrug resistance protein 1 ABCB1 0.0726
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0685
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0609
811 Translocator protein TSPO 0.0585
2421 Signal peptidase I lepB 0.0522
556 Alpha-1A adrenergic receptor ADRA1A 0.0518
4118 Cytochrome P450 3A5 CYP3A5 0.0501
820 Glycine receptor subunit alpha-2 GLRA2 0.0493
708 Alpha-tocopherol transfer protein TTPA 0.0483
5718 Cytochrome P450 2A6 CYP2A6 0.0461
20 Prostaglandin G/H synthase 1 PTGS1 0.0458
6107 Cytochrome P450 3A7 CYP3A7 0.0443
6500 Phospholipase A2 PLA2G1B 0.0399
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0389
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0389
3677 Penicillin-insensitive murein endopeptidase precursor mepA 0.0389
461 Glycine receptor subunit alpha-3 GLRA3 0.0372
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0361
5469 Head decoration protein shp 0.035
62 Glycine receptor subunit beta GLRB 0.0341
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0341
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0341
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0331
921 Glutamate receptor 2 GRIA2 0.0324
6106 Cytochrome P450 2C18 CYP2C18 0.0323
6024 Cytochrome P450 1A1 CYP1A1 0.0312
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0285
502 5-hydroxytryptamine 2A receptor HTR2A 0.0276
492 Histamine H1 receptor HRH1 0.0259
318 Alpha-2A adrenergic receptor ADRA2A 0.0252
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.025
131 Synaptic vesicular amine transporter SLC18A2 0.0246
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0237
290 Prostaglandin G/H synthase 2 PTGS2 0.0235
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0226
632 Alpha-1B adrenergic receptor ADRA1B 0.0226
4165 P2Y purinoceptor 2 P2RY2 0.0216
3941 Amine oxidase [flavin-containing] A MAOA 0.0216
6151 Monocarboxylate transporter 10 SLC16A10 0.0205
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0203
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0192
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0192
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0191
3939 Amine oxidase [flavin-containing] B MAOB 0.0187
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.0183
2654 Complement control protein C3L 0.0174
430 Follicle-stimulating hormone receptor FSHR 0.0164
629 Alpha-2B adrenergic receptor ADRA2B 0.016
590 5-hydroxytryptamine 2C receptor HTR2C 0.0159
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0159
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0155
5455 Arylsulfatase A ARSA 0.0151
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0149
1729 Solute carrier family 22 member 6 SLC22A6 0.0144
6144 Solute carrier family 22 member 2 SLC22A2 0.0143
814 Ryanodine receptor 1 RYR1 0.0143
862 Multidrug resistance-associated protein 1 ABCC1 0.0133
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0133
6145 Solute carrier family 22 member 1 SLC22A1 0.0132
51 Muscarinic acetylcholine receptor M3 CHRM3 0.013
465 Calmodulin CALM1 0.0128
468 Cytochrome P450 4A11 CYP4A11 0.0123
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0123
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0122
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0122
2164 Multidrug resistance-associated protein 4 ABCC4 0.012
450 Muscarinic acetylcholine receptor M4 CHRM4 0.012
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0119
766 Beta-2 adrenergic receptor ADRB2 0.0114
831 D(2) dopamine receptor DRD2 0.0113
54 Prothrombin F2 0.0112
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0112
789 Alpha-1D adrenergic receptor ADRA1D 0.011
723 Cytosolic phospholipase A2 PLA2G4A 0.0109
23 D(1A) dopamine receptor DRD1 0.0109
251 Alcohol dehydrogenase 1A ADH1A 0.0107
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0106
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0104
891 Dihydropteroate synthase folP 0.0103
5359 Dihydropteroate synthase folP 0.0103
7175 Dihydropteroate synthase sulI 0.0103
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.01
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0099
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0099
1268 Neuropeptide S receptor NPSR1 0.0099
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0099
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0099
193 Beta-1 adrenergic receptor ADRB1 0.0097
6102 Arylamine N-acetyltransferase 2 NAT2 0.0095
1024 Solute carrier family 22 member 11 SLC22A11 0.0095
444 Alcohol dehydrogenase 1B ADH1B 0.0095
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0093
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0092
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0091
1636 Trace amine-associated receptor 1 TAAR1 0.0088
3811 Cytochrome P450 19A1 CYP19A1 0.0087
378 Alpha-2C adrenergic receptor ADRA2C 0.0087
6031 Cytochrome P450 3A43 CYP3A43 0.0086
1898 Cytochrome P450 1B1 CYP1B1 0.0086
3426 Glutamine synthetase glnA 0.0084
3987 Glutamine synthetase GLUL 0.0084
696 Kappa-type opioid receptor OPRK1 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0082
341 5-hydroxytryptamine 3 receptor HTR3A 0.0082
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0082
517 Alcohol dehydrogenase 1C ADH1C 0.0081
467 Delta-type opioid receptor OPRD1 0.0081
6073 Potassium channel subfamily K member 9 KCNK9 0.0081
6072 Potassium channel subfamily K member 3 KCNK3 0.0081
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0077
320 5-hydroxytryptamine 1A receptor HTR1A 0.0076
6147 Solute carrier family 22 member 3 SLC22A3 0.0076
6143 Solute carrier family 22 member 7 SLC22A7 0.0075
122 P2Y purinoceptor 12 P2RY12 0.0075
847 Mu-type opioid receptor OPRM1 0.0073
136 Estrogen receptor ESR1 0.0073
1757 Myeloperoxidase MPO 0.0073
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0072
1517 Beta-3 adrenergic receptor ADRB3 0.0072
118 Organic cation/carnitine transporter 2 SLC22A5 0.0071
238 Peroxisome proliferator-activated receptor gamma PPARG 0.007
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0069
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0068
70 Type-1 angiotensin II receptor AGTR1 0.0067
172 Potassium channel subfamily K member 1 KCNK1 0.0065
592 Carbonic anhydrase 4 CA4 0.0065
6182 Cytochrome P450 2J2 CYP2J2 0.0064
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0064
133 Dihydropterate synthase sulI 0.0063
4116 Dihydropteroate synthetase Not Available 0.0062
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0059
6042 Prostaglandin reductase 2 PTGR2 0.0059
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0058
2207 Rhodopsin RHO 0.0057
6137 Multidrug resistance-associated protein 6 ABCC6 0.0057
776 Bile salt export pump ABCB11 0.0057
474 Acetylcholinesterase ACHE 0.0057
275 Arachidonate 5-lipoxygenase ALOX5 0.0056
4604 Liver carboxylesterase 1 CES1 0.0055
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0055
6432 Transporter snf 0.0053
731 HIV-1 protease HIV-1 protease 0.0053
3937 Fatty-acid amide hydrolase FAAH 0.0053
6141 Sodium/bile acid cotransporter SLC10A1 0.0052
6043 Putative G-protein coupled receptor 44 GPR44 0.0051
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0049
4056 N-arachidonyl glycine receptor GPR18 0.0049
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0049
4061 Peroxisomal sarcosine oxidase PIPOX 0.0049
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0049
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0049
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0049
4057 Glycine N-acyltransferase GLYAT 0.0049
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0049
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
1466 Glycyl-tRNA synthetase GARS 0.0049
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0049
3923 Cholinesterase BCHE 0.0049
1313 Lactoylglutathione lyase GLO1 0.0048
357 Carbonic anhydrase 2 CA2 0.0047
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
527 Prostacyclin receptor PTGIR 0.0045
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0045
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0045
49 Endothelin B receptor EDNRB 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0042
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0041
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0041
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0041
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0039
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0039
1656 CYP2B protein CYP2B 0.0039
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0039
373 Transthyretin TTR 0.0038
3884 SHMT2 protein SHMT2 0.0037
3901 SHMT2 protein SHMT2 0.0037
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0037
3879 Serine hydroxymethyltransferase 2 Not Available 0.0037
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
260 Cytochrome P450 51 ERG11 0.0037
761 Cytochrome P450 51 ERG11 0.0037
3163 Cytochrome P450 51 cyp51 0.0037
6020 Aldehyde oxidase AOX1 0.0037
130 Prostacyclin synthase PTGIS 0.0037
295 Carbonic anhydrase 1 CA1 0.0036
411 Glycine N-methyltransferase GNMT 0.0036
207 Glutathione synthetase GSS 0.0036
5269 Glutathione synthetase gshB 0.0036
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0036
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0036
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0036
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0036
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0036
1275 Estrogen sulfotransferase SULT1E1 0.0036
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0035
383 Glycine amidinotransferase, mitochondrial GATM 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0033
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0033
349 Serine--pyruvate aminotransferase AGXT 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0032
885 5-hydroxytryptamine 1B receptor HTR1B 0.0032
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0032
146 Androgen receptor AR 0.0032
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0032
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.003
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.003
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0028
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
725 5-hydroxytryptamine 1D receptor HTR1D 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
817 DNA topoisomerase 2-alpha TOP2A 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0026
427 Substance-P receptor TACR1 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
1541 Metalloproteinase mmp20 0.0025
183 Vascular endothelial growth factor A VEGFA 0.0024
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
904 Glutathione S-transferase P GSTP1 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
1618 High affinity nerve growth factor receptor NTRK1 0.0023
94 5-hydroxytryptamine 4 receptor HTR4 0.0023
124 Histamine H2 receptor HRH2 0.0023
407 Vascular endothelial growth factor receptor 2 KDR 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
153 Dopamine beta-hydroxylase DBH 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
1502 Peroxisome proliferator-activated receptor delta PPARD 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
88 Retinoic acid receptor RXR-beta RXRB 0.0019
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
777 Tumor necrosis factor TNF 0.0019
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
869 Estrogen receptor beta ESR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0018
738 Monocarboxylate transporter 1 SLC16A1 0.0018
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0016
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
6014 Cytochrome P450 2A13 CYP2A13 0.0016
1648 Elastin ELN 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
614 Progesterone receptor PGR 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
2232 Interleukin-5 IL5 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0014
1593 Mucin-2 MUC2 0.0014
844 Epidermal growth factor receptor EGFR 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
518 Peroxidase/catalase T katG 0.0012
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
164 Histamine H4 receptor HRH4 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
638 D(3) dopamine receptor DRD3 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
432 D(4) dopamine receptor DRD4 0.0011
1629 Transcription factor AP-1 JUN 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
3809 Estrogen-related receptor gamma ESRRG 0.001
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
563 Thyroid peroxidase TPO 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
4122 Histone deacetylase 2 HDAC2 0.001
16 Adenosine A1 receptor ADORA1 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
716 5-hydroxytryptamine 7 receptor HTR7 0.0009
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
1192 Sulfotransferase 1A1 SULT1A1 0.0009
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0009
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
26 Vascular endothelial growth factor receptor 3 FLT4 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
3830 Calreticulin CALR 0.0008
4773 Deoxycytidine kinase DCK 0.0008
161 Tubulin beta chain TUBB 0.0008
312 Tubulin beta chain TUB2 0.0008
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1630 Integrin beta-2 ITGB2 0.0007
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1374 Natriuretic peptides B NPPB 0.0007
1827 Gap junction alpha-1 protein GJA1 0.0007
1908 Vascular cell adhesion protein 1 VCAM1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
4217 Telomerase reverse transcriptase TERT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
3947 Xanthine dehydrogenase/oxidase XDH 0.0007
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
239 Coagulation factor X F10 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6044 Serum paraoxonase/lactonase 3 PON3 0.0006
3221 Cytochrome c4 cc4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
7 Nitric oxide synthase, inducible NOS2 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1507 Cytochrome c CYCS 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6218 Pannexin-1 PANX1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
1039 Histone deacetylase 9 HDAC9 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
936 Ephrin type-A receptor 2 EPHA2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
165 FL cytokine receptor FLT3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
3957 Adenosine deaminase ADA 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
162 Retinoic acid receptor gamma-1 RARG 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
908 Glutathione S-transferase theta-1 GSTT1 0.0004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
469 Annexin A1 ANXA1 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
489 Monocarboxylate transporter 2 SLC16A7 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0002
871 Glucocorticoid receptor NR3C1 0.0002
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
↑