DT-Web

DB01166 - Cilostazol


Identification
Name Cilostazol
Accession Number DB01166 (APRD00155)
Type small molecule
Description Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease. It is manufactured by Otsuka Pharmaceutical Co. under the trade name Pletal. Although drugs similar to cilostazol have increased the risk of death in patients with congestive heart failure, studies of significant size have not addressed people without the disease. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 369.4607
Groups approved
Monoisotopic Weight 369.216475133
Pharmacology
Indication For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
Mechanism of action Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Absorption Cilostazol is absorbed after oral administration. A high fat meal increases absorption, with an approximately 90% increase in Cmax and a 25% increase in AUC. Absolute bioavailability is not known.
Protein binding 95-98%
Biotransformation Hepatic. Cilostazol is extensively metabolized by hepatic cytochrome P-450 enzymes, mainly 3A4, and, to a lesser extent, 2C19, with metabolites largely excreted in urine. Two metabolites are active, with one metabolite appearing to account for at least 50% of the pharmacologic (PDE III inhibition) activity after administration of cilostazol.
Route of elimination Cilostazol is extensively metabolized by hepatic cytochrome P-450 enzymes, mainly 3A4, and, to a lesser extent, 2C19, with metabolites largely excreted in urine. Cilostazol is eliminated predominately by metabolism and subsequent urinary excretion of metabolites. The primary route of elimination was via the urine (74%), with the remainder excreted in feces (20%). No measurable amount of unchanged cilostazol was excreted in the urine, and less than 2% of the dose was excreted as 3,4-dehydro-cilostazol. About 30% of the dose was excreted in urine as 4'-trans-hydroxy-cilostazol.
Toxicity Information on acute overdosage with cilostazol in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias. The oral LD50 of cilostazol is >5.0 g/kg in mice and rats and >2.0 g/kg in dogs.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Diltiazem Diltiazem, a moderate CYP3A4 inhibitor, may increase the serum concentration of cilostazol by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cilostazol if diltiazem is initiated, discontinued or dose changed.
Erythromycin Erythromycin increases the effect of cilostazol
Fluconazole Fluconazole may decrease the effect of cilostazol.
Fluoxetine Fluoxetine, a moderate CYP2C19 inhibitor, may decrease the metabolism of cilostazol. Monitor for changes in the therapeutic and adverse effects of cilostazol if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine Fluvoxamine increases the effect of cilostazol
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Itraconazole Itraconazole may increase the effect of cilostazol.
Josamycin Erythromycin increases the effect of cilostazol
Ketoconazole Ketoconazole may increase the effect of cilostazol.
Nefazodone Nefazodone increases the effect of cilostazol
Omeprazole Omeprazole increases the effect of cilostazol
Sertraline Sertraline increases the effect of cilostazol
Telithromycin Telithromycin may reduce clearance of Cilostazol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cilostazol if Telithromycin is initiated, discontinued or dose changed.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Cilostazol. Consider alternate therapy or monitor for adverse/toxic effects of Cilostazol if Ticlopidine is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Cilostazol. Monitor for increased bleeding during concomitant thearpy.
Voriconazole Voriconzole may increase the serum concentration of cilostazol by decreasing its metabolism. Monitor for increased therapeutic/adverse effects of cilostazol and consider reducing the dose during concomitant therapy.
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment, grapefruit can significantly increase serum levels of this product.
  • Take on an empty stomach, a lipid rich meal will increase absorption.

Targets


cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Name cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Gene Name PDE3A
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Hong KW, Lee JH, Kima KY, Park SY, Lee WS: Cilostazol: therapeutic potential against focal cerebral ischemic damage. Curr Pharm Des. 2006;12(5):565-73. - Pubmed
  • Schror K: The pharmacology of cilostazol. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9. - Pubmed
  • Mokry J, Mokra D, Nosalova G, Beharkova M, Feherova Z: Influence of selective inhibitors of phosphodiesterase 3 and 4 on cough and airway reactivity. J Physiol Pharmacol. 2008 Dec;59 Suppl 6:473-82. - Pubmed
  • Parkkonen J, Hasala H, Moilanen E, Giembycz MA, Kankaanranta H: Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol. Pulm Pharmacol Ther. 2008;21(3):499-506. Epub 2007 Nov 22. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.3941
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3148
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Suri A, Forbes WP, Bramer SL: Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. - Pubmed
DTHybrid score 0.3706
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
DTHybrid score 0.6607
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Suri A, Forbes WP, Bramer SL: Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. - Pubmed
DTHybrid score 0.4485
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Suri A, Forbes WP, Bramer SL: Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. - Pubmed
DTHybrid score 0.4699

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2936
1588 Multidrug resistance protein 1 ABCB1 0.2417
4924 Cytochrome P450 2C8 CYP2C8 0.2003
6030 Cytochrome P450 2B6 CYP2B6 0.1545
6013 Cytochrome P450 2E1 CYP2E1 0.147
6024 Cytochrome P450 1A1 CYP1A1 0.1205
5718 Cytochrome P450 2A6 CYP2A6 0.0848
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0738
587 Serum albumin ALB 0.0728
492 Histamine H1 receptor HRH1 0.0714
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0643
824 Sodium-dependent serotonin transporter SLC6A4 0.0623
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0598
20 Prostaglandin G/H synthase 1 PTGS1 0.0583
1181 Alpha-1-acid glycoprotein 1 ORM1 0.055
6106 Cytochrome P450 2C18 CYP2C18 0.0544
777 Tumor necrosis factor TNF 0.0535
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0527
831 D(2) dopamine receptor DRD2 0.0525
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.052
502 5-hydroxytryptamine 2A receptor HTR2A 0.0519
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0498
4122 Histone deacetylase 2 HDAC2 0.0497
16 Adenosine A1 receptor ADORA1 0.0485
556 Alpha-1A adrenergic receptor ADRA1A 0.0482
6145 Solute carrier family 22 member 1 SLC22A1 0.048
862 Multidrug resistance-associated protein 1 ABCC1 0.0462
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0447
847 Mu-type opioid receptor OPRM1 0.0442
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0436
320 5-hydroxytryptamine 1A receptor HTR1A 0.0432
1898 Cytochrome P450 1B1 CYP1B1 0.0428
3811 Cytochrome P450 19A1 CYP19A1 0.0402
318 Alpha-2A adrenergic receptor ADRA2A 0.0396
6144 Solute carrier family 22 member 2 SLC22A2 0.0393
6143 Solute carrier family 22 member 7 SLC22A7 0.0392
766 Beta-2 adrenergic receptor ADRB2 0.0387
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0382
1729 Solute carrier family 22 member 6 SLC22A6 0.0367
713 Sodium-dependent dopamine transporter SLC6A3 0.0362
6031 Cytochrome P450 3A43 CYP3A43 0.0356
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0355
23 D(1A) dopamine receptor DRD1 0.0348
590 5-hydroxytryptamine 2C receptor HTR2C 0.0344
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0336
193 Beta-1 adrenergic receptor ADRB1 0.033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0329
1178 Adenosine A2a receptor ADORA2A 0.032
632 Alpha-1B adrenergic receptor ADRA1B 0.0319
871 Glucocorticoid receptor NR3C1 0.0318
467 Delta-type opioid receptor OPRD1 0.0315
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0315
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0311
731 HIV-1 protease HIV-1 protease 0.0311
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0306
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0303
118 Organic cation/carnitine transporter 2 SLC22A5 0.0303
776 Bile salt export pump ABCB11 0.0302
341 5-hydroxytryptamine 3 receptor HTR3A 0.0299
638 D(3) dopamine receptor DRD3 0.0299
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0292
696 Kappa-type opioid receptor OPRK1 0.0286
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0283
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.028
260 Cytochrome P450 51 ERG11 0.0274
761 Cytochrome P450 51 ERG11 0.0274
3163 Cytochrome P450 51 cyp51 0.0274
3941 Amine oxidase [flavin-containing] A MAOA 0.0272
885 5-hydroxytryptamine 1B receptor HTR1B 0.027
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0269
817 DNA topoisomerase 2-alpha TOP2A 0.0268
290 Prostaglandin G/H synthase 2 PTGS2 0.0262
36 Insulin receptor INSR 0.0258
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0253
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0246
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0245
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0236
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0232
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0232
390 Adenosine A3 receptor ADORA3 0.0231
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0229
629 Alpha-2B adrenergic receptor ADRA2B 0.0225
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0223
725 5-hydroxytryptamine 1D receptor HTR1D 0.0219
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0216
378 Alpha-2C adrenergic receptor ADRA2C 0.0212
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0212
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0211
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.021
6182 Cytochrome P450 2J2 CYP2J2 0.021
136 Estrogen receptor ESR1 0.0209
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0205
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
432 D(4) dopamine receptor DRD4 0.0201
6147 Solute carrier family 22 member 3 SLC22A3 0.02
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0199
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
465 Calmodulin CALM1 0.0198
833 Organic cation/carnitine transporter 1 SLC22A4 0.0197
6142 Solute carrier family 22 member 8 SLC22A8 0.0197
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0195
789 Alpha-1D adrenergic receptor ADRA1D 0.0195
3939 Amine oxidase [flavin-containing] B MAOB 0.0194
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0191
468 Cytochrome P450 4A11 CYP4A11 0.0189
614 Progesterone receptor PGR 0.0189
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0186
2164 Multidrug resistance-associated protein 4 ABCC4 0.0185
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0182
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.018
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0178
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0177
6148 Multidrug resistance-associated protein 7 ABCC10 0.0175
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0174
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0172
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0172
3923 Cholinesterase BCHE 0.0162
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0161
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0158
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0158
232 Corticosteroid-binding globulin SERPINA6 0.0156
737 Mineralocorticoid receptor NR3C2 0.0156
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0152
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0149
6220 Aryl hydrocarbon receptor AHR 0.0146
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0142
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0142
818 50S ribosomal protein L10 rplJ 0.0139
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0138
844 Epidermal growth factor receptor EGFR 0.0132
716 5-hydroxytryptamine 7 receptor HTR7 0.0132
146 Androgen receptor AR 0.0132
756 Sex hormone-binding globulin SHBG 0.0131
504 Mast/stem cell growth factor receptor KIT 0.013
163 D(1B) dopamine receptor DRD5 0.013
124 Histamine H2 receptor HRH2 0.0128
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
811 Translocator protein TSPO 0.0126
436 5-hydroxytryptamine 2B receptor HTR2B 0.0125
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0124
94 5-hydroxytryptamine 4 receptor HTR4 0.0123
26 Vascular endothelial growth factor receptor 3 FLT4 0.0122
380 Cytochrome P450 17A1 CYP17A1 0.0119
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0118
32 Vascular endothelial growth factor receptor 1 FLT1 0.0117
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0115
228 Beta platelet-derived growth factor receptor PDGFRB 0.0114
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0114
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0114
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0114
407 Vascular endothelial growth factor receptor 2 KDR 0.0113
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0113
1256 5-hydroxytryptamine 6 receptor HTR6 0.0113
122 P2Y purinoceptor 12 P2RY12 0.0112
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0111
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0111
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0111
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0111
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.011
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.011
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.011
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0109
1656 CYP2B protein CYP2B 0.0108
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0107
1010 Cytochrome P450 51A1 CYP51A1 0.0106
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0106
4604 Liver carboxylesterase 1 CES1 0.0102
474 Acetylcholinesterase ACHE 0.0102
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0101
161 Tubulin beta chain TUBB 0.01
312 Tubulin beta chain TUB2 0.01
6020 Aldehyde oxidase AOX1 0.0097
427 Substance-P receptor TACR1 0.0097
6014 Cytochrome P450 2A13 CYP2A13 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
571 Melatonin receptor type 1A MTNR1A 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0096
268 Adenosine A2b receptor ADORA2B 0.0095
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0095
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0091
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0089
6136 Multidrug resistance-associated protein 5 ABCC5 0.0088
6137 Multidrug resistance-associated protein 6 ABCC6 0.0087
4120 NADPH--cytochrome P450 reductase POR 0.0087
952 Dipeptidyl peptidase 4 DPP4 0.0087
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0086
29 Tubulin beta-1 chain TUBB1 0.0086
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0086
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0085
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0085
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0084
528 5-hydroxytryptamine 1E receptor HTR1E 0.0084
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
1024 Solute carrier family 22 member 11 SLC22A11 0.0082
3957 Adenosine deaminase ADA 0.0082
273 Apoptosis regulator Bcl-2 BCL2 0.0081
2539 Tubulin alpha-1 chain TUBA4A 0.0081
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0081
6102 Arylamine N-acetyltransferase 2 NAT2 0.008
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
3947 Xanthine dehydrogenase/oxidase XDH 0.008
1757 Myeloperoxidase MPO 0.008
705 Glutamate receptor 1 GRIA1 0.0079
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0079
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0079
173 Toll-like receptor 7 TLR7 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
131 Synaptic vesicular amine transporter SLC18A2 0.0076
6141 Sodium/bile acid cotransporter SLC10A1 0.0075
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0075
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0075
70 Type-1 angiotensin II receptor AGTR1 0.0074
1517 Beta-3 adrenergic receptor ADRB3 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0071
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.007
373 Transthyretin TTR 0.007
165 FL cytokine receptor FLT3 0.007
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0069
2112 Toll-like receptor 9 TLR9 0.0069
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0069
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0069
814 Ryanodine receptor 1 RYR1 0.0068
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0068
869 Estrogen receptor beta ESR2 0.0068
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0066
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0066
4238 50S ribosomal protein L4 rplD 0.0065
5578 50S ribosomal protein L4 rplD 0.0065
6173 50S ribosomal protein L4 rplD 0.0065
6219 50S ribosomal protein L4 rplD 0.0065
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
284 DNA-directed RNA polymerase beta chain rpoB 0.0064
5773 DNA-directed RNA polymerase beta chain rpoB 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
6044 Serum paraoxonase/lactonase 3 PON3 0.0063
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0063
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0062
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0062
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
592 Carbonic anhydrase 4 CA4 0.0062
295 Carbonic anhydrase 1 CA1 0.0061
1050 Bile salt sulfotransferase SULT2A1 0.006
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
4311 tRNA TRDMT1 0.0059
4325 tRNA trmD 0.0059
4328 tRNA trmD 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0058
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0058
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0058
239 Coagulation factor X F10 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
921 Glutamate receptor 2 GRIA2 0.0057
6432 Transporter snf 0.0057
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0057
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0057
5300 Antigen peptide transporter 1 TAP1 0.0056
469 Annexin A1 ANXA1 0.0056
6506 Stathmin-4 STMN4 0.0055
1196 Complement decay-accelerating factor CD55 0.0055
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0054
511 5-hydroxytryptamine 1F receptor HTR1F 0.0054
823 Fibroblast growth factor receptor 2 FGFR2 0.0054
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0054
1618 High affinity nerve growth factor receptor NTRK1 0.0054
1852 Microtubule-associated protein 2 MAP2 0.0054
891 Dihydropteroate synthase folP 0.0054
5359 Dihydropteroate synthase folP 0.0054
7175 Dihydropteroate synthase sulI 0.0054
5998 Toll-like receptor 8 TLR8 0.0053
738 Monocarboxylate transporter 1 SLC16A1 0.0053
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0053
49 Endothelin B receptor EDNRB 0.0052
174 Sigma 1-type opioid receptor SIGMAR1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
976 Platelet glycoprotein IX GP9 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.005
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.005
365 Dihydrofolate reductase DHFR 0.005
2381 Dihydrofolate reductase DFR1 0.005
2833 Dihydrofolate reductase Not Available 0.005
2931 Dihydrofolate reductase folA 0.005
3544 Dihydrofolate reductase folA 0.005
3682 Dihydrofolate reductase folA 0.005
6642 Dihydrofolate reductase folA 0.005
6756 Dihydrofolate reductase dfrA 0.005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
68 Cannabinoid receptor 1 CNR1 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
2808 Chloramphenicol acetyltransferase 3 cat3 0.0047
33 Cystine/glutamate transporter SLC7A11 0.0047
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0047
856 Vitamin D3 receptor VDR 0.0047
153 Dopamine beta-hydroxylase DBH 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
357 Carbonic anhydrase 2 CA2 0.0046
3086 Plasmepsin-2 Not Available 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0046
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0046
84 Nuclear receptor 0B1 NR0B1 0.0045
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0045
6043 Putative G-protein coupled receptor 44 GPR44 0.0045
4203 Histamine N-methyltransferase HNMT 0.0045
319 Opioid receptor, sigma 1 OPRS1 0.0045
275 Arachidonate 5-lipoxygenase ALOX5 0.0045
3601 Dihydropteroate synthase 1 folP1 0.0043
3807 Dihydropteroate synthase 1 folP1 0.0043
3808 Dihydropteroate synthase 2 folP2 0.0043
2417 Chloramphenicol acetyltransferase cat 0.0043
3278 Chloramphenicol acetyltransferase cat 0.0043
1630 Integrin beta-2 ITGB2 0.0043
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0043
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0043
183 Vascular endothelial growth factor A VEGFA 0.0043
2810 Dr hemagglutinin structural subunit draA 0.0043
1629 Transcription factor AP-1 JUN 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0042
4773 Deoxycytidine kinase DCK 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
904 Glutathione S-transferase P GSTP1 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0041
518 Peroxidase/catalase T katG 0.0041
1192 Sulfotransferase 1A1 SULT1A1 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0041
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
54 Prothrombin F2 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
563 Thyroid peroxidase TPO 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
85 Growth hormone receptor GHR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0037
482 Glycine receptor subunit alpha-1 GLRA1 0.0037
1864 RET proto-oncogene RET 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0037
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0037
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
634 Squalene monooxygenase SQLE 0.0036
7196 Squalene monooxygenase ERG1 0.0036
780 Retinoic acid receptor RXR-gamma RXRG 0.0036
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
3856 Fibroblast growth factor receptor 3 FGFR3 0.0035
6174 50S ribosomal protein L32 rpmF 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0033
88 Retinoic acid receptor RXR-beta RXRB 0.0033
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0032
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
572 Integrin alpha-L ITGAL 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6146 High affinity copper uptake protein 1 SLC31A1 0.003
6048 Troponin C, skeletal muscle TNNC2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
7 Nitric oxide synthase, inducible NOS2 0.0028
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
5787 Angiopoietin-1 receptor TEK 0.0027
6085 Fatty acid-binding protein, intestinal FABP2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0026
4103 Proteasome subunit beta type 2 PSMB2 0.0026
4102 Proteasome subunit beta type 5 PSMB5 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
4101 Proteasome subunit beta type 1 PSMB1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1648 Elastin ELN 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
936 Ephrin type-A receptor 2 EPHA2 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
164 Histamine H4 receptor HRH4 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0023
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0023
162 Retinoic acid receptor gamma-1 RARG 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
3809 Estrogen-related receptor gamma ESRRG 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
3810 Catechol O-methyltransferase COMT 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
1992 Vitamin D-binding protein GC 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
1820 Beta-nerve growth factor NGF 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
1039 Histone deacetylase 9 HDAC9 0.002
106 Cannabinoid receptor 2 CNR2 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
908 Glutathione S-transferase theta-1 GSTT1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
1253 Interferon gamma IFNG 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3830 Calreticulin CALR 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1541 Metalloproteinase mmp20 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6859 Protein S100-A4 S100A4 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
896 Glutathione S-transferase Mu 1 GSTM1 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2132 Protein S100-B S100B 0.0009
6218 Pannexin-1 PANX1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2298 Cytochrome P450-cam camC 0.0007
2021 Thrombomodulin THBD 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
2207 Rhodopsin RHO 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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