DT-Web

DB00374 - Treprostinil


Identification
Name Treprostinil
Accession Number DB00374 (APRD01272)
Type small molecule
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. Treprostinil is marketed as Remodulin®. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 390.5131
Groups approved
Monoisotopic Weight 390.240624198
Pharmacology
Indication For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Mechanism of action The major pharmacological actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. In addition to treprostinil's direct vasodilatory effects, it also inhibits inflammatory cytokine. As a synthetic analogue of prostacyclin, it binds to the prostacyclin receptor, which subsequently induces the aforementioned downstream effects.
Absorption Relatively rapid and complete after subcutaneous infusion, with an absolute bioavailability approximately 100%. In patients with mild (n=4) or moderate (n=5) hepatic insufficiency and portopulmonary hypertension following a subcutaneous dose of 10 ng per kg of body weight per min for 150 mins the AUC 0-∞ was increased 3-fold and 5-fold respectively.
Protein binding Human plasma protein binding is approximately 91% in in vitro concentrations ranging from 330 to 10,000 µ/L.
Biotransformation Substantially metabolized by the liver, but the precise enzymes responsible are unknown. Five metabolites have been described (HU1 through HU5) however, the biological activity and metabolic fate of these are unknown. The chemical structure of HU1 is unknown. The metabolite HU5 is the glucuronide conjugate of treprostinil. The other metabolites are formed by oxidation of the 3-hydroxyoctyl side chain (HU2) and subsequent additional oxidation (HU3) or dehydration (HU4). Study results of in vitro human hepatic cytochrome P450 demonstrates that treprostinil does not inhibit CYP-1A2, 2C9, 2C19, 2D6, 2E1, or 3A. Whether treprostinil induces these enzymes has not been studied.
Route of elimination Not Available
Toxicity Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of treprostinil.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abciximab The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Abciximab. Monitor for increased bleeding during concomitant thearpy.
Acebutolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Acenocoumarol The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Acenocoumarol. Monitor for increased bleeding during concomitant thearpy.
Acetazolamide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Acetylsalicylic acid The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Acetylsalicylic acid. Monitor for increased bleeding during concomitant thearpy.
Aliskiren Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Amiloride Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Aminosalicylic Acid The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the salicylate, Aminosalicylic acid. Monitor for increased bleeding during concomitant thearpy.
Amlodipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Amyl Nitrite Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Anagrelide The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Anagrelide. Monitor for increased bleeding during concomitant thearpy.
Apraclonidine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Argatroban The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Argatroban. Monitor for increased bleeding during concomitant thearpy.
Atenolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Benazepril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Bendroflumethiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Betaxolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Bisoprolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Bivalirudin The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Bivalirudin. Monitor for increased bleeding during concomitant thearpy.
Brimonidine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Bumetanide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Candesartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Captopril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Carteolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Carvedilol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Celecoxib The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Celecoxib. Monitor for increased bleeding during concomitant thearpy.
Celiprolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Chlorothiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Chlorthalidone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Cilazapril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Cilostazol The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Cilostazol. Monitor for increased bleeding during concomitant thearpy.
Citalopram The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Citalopram. Monitor for increased bleeding during concomitant thearpy.
Clevidipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Clonidine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Clopidogrel The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Clopidogrel. Monitor for increased bleeding during concomitant thearpy.
Cyclandelate Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Dexmedetomidine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Dichlorphenamide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Diclofenac The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Diclofenac. Monitor for increased bleeding during concomitant thearpy.
Diflunisal The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Diflunisal. Monitor for increased bleeding during concomitant thearpy.
Diltiazem Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Dipyridamole The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Dipyridamole. Monitor for increased bleeding during concomitant thearpy. Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Doxazosin Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Drospirenone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Drotrecogin alfa The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Drotrecogin alfa. Monitor for increased bleeding during concomitant thearpy.
Enalapril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Enoxaparin The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Exoxaparin. Monitor for increased bleeding during concomitant thearpy.
Eplerenone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Eprosartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Eptifibatide The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Eptifibatide. Monitor for increased bleeding during concomitant thearpy.
Escitalopram The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Escitalopram. Monitor for increased bleeding during concomitant thearpy.
Esmolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Ethacrynic acid Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Etodolac The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Etodolac. Monitor for increased bleeding during concomitant thearpy.
Felodipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Fenoprofen The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Fenoprofen. Monitor for increased bleeding during concomitant thearpy.
Fluoxetine The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Fluoxetine. Monitor for increased bleeding during concomitant thearpy.
Flurbiprofen The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Flurbiprofen. Monitor for increased bleeding during concomitant thearpy.
Fluvoxamine The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Fluvoxamine. Monitor for increased bleeding during concomitant thearpy.
Fosinopril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Furosemide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Guanabenz Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Guanfacine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Heparin The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Heparin. Monitor for increased bleeding during concomitant thearpy.
Hydralazine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Hydrochlorothiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Hydroflumethiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Ibuprofen The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Ibuprofen. Monitor for increased bleeding during concomitant thearpy.
Indapamide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Indomethacin The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Indomethacin. Monitor for increased bleeding during concomitant thearpy.
Irbesartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Isosorbide Dinitrate Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Isosorbide Mononitrate Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Isradipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Ketoprofen The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Ketoprofen. Monitor for increased bleeding during concomitant thearpy.
Ketorolac The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Ketorolac. Monitor for increased bleeding during concomitant thearpy.
Labetalol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Lepirudin The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Lepirudin. Monitor for increased bleeding during concomitant thearpy.
Levobunolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Lisinopril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Losartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Lumiracoxib The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Lumiracoxib. Monitor for increased bleeding during concomitant thearpy.
Mannitol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Meclofenamic acid The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Meclofenamate. Monitor for increased bleeding during concomitant thearpy.
Mefenamic acid The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Mefenamic acid. Monitor for increased bleeding during concomitant thearpy.
Meloxicam The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Meloxicam. Monitor for increased bleeding during concomitant thearpy.
Methazolamide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Methyclothiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Metipranolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Metolazone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Metoprolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Minoxidil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Moexipril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nabumetone The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Nabumetone. Monitor for increased bleeding during concomitant thearpy.
Nadolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Naproxen The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Naproxen. Monitor for increased bleeding during concomitant thearpy.
Nebivolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nesiritide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nicardipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nifedipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nimodipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nisoldipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nitrendipine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nitroglycerin Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Nitroprusside Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Olmesartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Oxaprozin The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Oxaprozin. Monitor for increased bleeding during concomitant thearpy.
Oxprenolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Papaverine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Paroxetine The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Paroxetine. Monitor for increased bleeding during concomitant thearpy.
Penbutolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Perindopril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Phenoxybenzamine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Phentolamine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Pindolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Piroxicam The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Piroxicam. Monitor for increased bleeding during concomitant thearpy.
Polythiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Prazosin Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Quinapril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Ramipril Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Reserpine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Rivaroxaban The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Rivaroxaban. Monitor for increased bleeding during concomitant thearpy.
Salsalate The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the salicylate, Salsalate. Monitor for increased bleeding during concomitant thearpy.
Sertraline The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Sertraline. Monitor for increased bleeding during concomitant thearpy.
Sotalol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Spironolactone Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Sulindac The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Sulindac. Monitor for increased bleeding during concomitant thearpy.
Telmisartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Terazosin Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tiaprofenic acid The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Tiaprofenic acid. Monitor for increased bleeding during concomitant thearpy.
Ticlopidine The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Ticlopidine. Monitor for increased bleeding during concomitant thearpy.
Timolol Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tirofiban The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Tirofiban. Monitor for increased bleeding during concomitant thearpy.
Tizanidine Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tolazoline Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tolmetin The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Tolmetin. Monitor for increased bleeding during concomitant thearpy.
Torasemide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trandolapril The prostacyclin analogue, Treprostinil, may increase the hypotensive effect of Trandolapril.
Triamterene Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trichlormethiazide Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Urea Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Valsartan Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Verapamil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Warfarin The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Warfarin. Monitor for increased bleeding during concomitant thearpy.
Food Interactions Not Available

Targets


Prostacyclin receptor
Name Prostacyclin receptor
Gene Name PTGIR
Pharmacological action yes
Actions agonist
References
  • Falcetti E, Hall SM, Phillips PG, Patel J, Morrell NW, Haworth SG, Clapp LH: Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2010 Jul 9. - Pubmed
  • Sprague RS, Bowles EA, Hanson MS, DuFaux EA, Sridharan M, Adderley S, Ellsworth ML, Stephenson AH: Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes. Microcirculation. 2008 Jul;15(5):461-71. - Pubmed
  • Olschewski H, Rose F, Schermuly R, Ghofrani HA, Enke B, Olschewski A, Seeger W: Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacol Ther. 2004 May;102(2):139-53. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4352
Peroxisome proliferator-activated receptor delta
Name Peroxisome proliferator-activated receptor delta
Gene Name PPARD
Pharmacological action yes
Actions agonist
References
  • Ali FY, Egan K, FitzGerald GA, Desvergne B, Wahli W, Bishop-Bailey D, Warner TD, Mitchell JA: Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol. 2006 Feb;34(2):242-6. Epub 2005 Oct 20. - Pubmed
DTHybrid score 0.9738
P2Y purinoceptor 12
Name P2Y purinoceptor 12
Gene Name P2RY12
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4853

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Gotzkowsky SK, Dingemanse J, Lai A, Mottola D, Laliberte K: Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. J Clin Pharmacol. 2010 Jul;50(7):829-34. doi: 10.1177/0091270009351173. Epub 2010 Feb 4. - Pubmed
DTHybrid score 0.3319

Predictions


Id Partner name Gene Name Score
130 Prostacyclin synthase PTGIS 0.1397
4512 Cytochrome P450 3A4 CYP3A4 0.1278
6016 Cytochrome P450 2C19 CYP2C19 0.104
4924 Cytochrome P450 2C8 CYP2C8 0.0884
4200 Cytochrome P450 1A2 CYP1A2 0.0668
6030 Cytochrome P450 2B6 CYP2B6 0.0665
1588 Multidrug resistance protein 1 ABCB1 0.0653
768 FK506-binding protein 1A FKBP1A 0.0629
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0588
4119 Cytochrome P450 2D6 CYP2D6 0.0573
238 Peroxisome proliferator-activated receptor gamma PPARG 0.054
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0529
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0485
20 Prostaglandin G/H synthase 1 PTGS1 0.0465
587 Serum albumin ALB 0.0437
6024 Cytochrome P450 1A1 CYP1A1 0.0414
4118 Cytochrome P450 3A5 CYP3A5 0.0358
6013 Cytochrome P450 2E1 CYP2E1 0.0353
672 Prostaglandin F2-alpha receptor PTGFR 0.0341
290 Prostaglandin G/H synthase 2 PTGS2 0.034
1729 Solute carrier family 22 member 6 SLC22A6 0.0325
6228 Nuclear receptor coactivator 1 NCOA1 0.0309
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0286
1792 Tissue-type plasminogen activator PLAT 0.0286
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0255
6143 Solute carrier family 22 member 7 SLC22A7 0.0241
1024 Solute carrier family 22 member 11 SLC22A11 0.0238
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.023
6142 Solute carrier family 22 member 8 SLC22A8 0.0226
6144 Solute carrier family 22 member 2 SLC22A2 0.0218
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0209
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0209
6107 Cytochrome P450 3A7 CYP3A7 0.0197
5718 Cytochrome P450 2A6 CYP2A6 0.0197
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0192
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0191
4604 Liver carboxylesterase 1 CES1 0.0174
1757 Myeloperoxidase MPO 0.0164
759 Free fatty acid receptor 1 FFAR1 0.0162
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0162
6043 Putative G-protein coupled receptor 44 GPR44 0.016
1714 Mitogen-activated protein kinase 3 MAPK3 0.0151
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.014
1053 BC269730_2 FADS1 0.0139
1395 Sodium/calcium exchanger 1 SLC8A1 0.0139
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0135
3312 Fatty acid-binding protein, brain FABP7 0.013
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0128
6106 Cytochrome P450 2C18 CYP2C18 0.0116
822 Aldose reductase AKR1B1 0.0116
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.011
891 Dihydropteroate synthase folP 0.0103
5359 Dihydropteroate synthase folP 0.0103
7175 Dihydropteroate synthase sulI 0.0103
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0095
492 Histamine H1 receptor HRH1 0.0094
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0083
862 Multidrug resistance-associated protein 1 ABCC1 0.008
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0078
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0077
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0076
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0075
136 Estrogen receptor ESR1 0.0073
824 Sodium-dependent serotonin transporter SLC6A4 0.0071
2164 Multidrug resistance-associated protein 4 ABCC4 0.0071
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.007
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0068
70 Type-1 angiotensin II receptor AGTR1 0.0067
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0064
133 Dihydropterate synthase sulI 0.0063
4116 Dihydropteroate synthetase Not Available 0.0062
1898 Cytochrome P450 1B1 CYP1B1 0.0059
341 5-hydroxytryptamine 3 receptor HTR3A 0.0058
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0058
3811 Cytochrome P450 19A1 CYP19A1 0.0057
502 5-hydroxytryptamine 2A receptor HTR2A 0.0056
6145 Solute carrier family 22 member 1 SLC22A1 0.0053
731 HIV-1 protease HIV-1 protease 0.0053
776 Bile salt export pump ABCB11 0.0051
540 Sodium-dependent noradrenaline transporter SLC6A2 0.005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0047
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0046
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
713 Sodium-dependent dopamine transporter SLC6A3 0.0044
49 Endothelin B receptor EDNRB 0.0044
3941 Amine oxidase [flavin-containing] A MAOA 0.0043
578 Endothelin-1 receptor EDNRA 0.0041
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0041
3939 Amine oxidase [flavin-containing] B MAOB 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0041
590 5-hydroxytryptamine 2C receptor HTR2C 0.004
831 D(2) dopamine receptor DRD2 0.004
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0039
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0039
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0038
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0037
260 Cytochrome P450 51 ERG11 0.0037
761 Cytochrome P450 51 ERG11 0.0037
3163 Cytochrome P450 51 cyp51 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
295 Carbonic anhydrase 1 CA1 0.0036
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0036
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0036
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0036
1275 Estrogen sulfotransferase SULT1E1 0.0036
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0035
118 Organic cation/carnitine transporter 2 SLC22A5 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0033
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0033
847 Mu-type opioid receptor OPRM1 0.0033
696 Kappa-type opioid receptor OPRK1 0.0033
6031 Cytochrome P450 3A43 CYP3A43 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0032
146 Androgen receptor AR 0.0032
556 Alpha-1A adrenergic receptor ADRA1A 0.0032
811 Translocator protein TSPO 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
468 Cytochrome P450 4A11 CYP4A11 0.0031
632 Alpha-1B adrenergic receptor ADRA1B 0.0031
467 Delta-type opioid receptor OPRD1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
766 Beta-2 adrenergic receptor ADRB2 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
465 Calmodulin CALM1 0.003
318 Alpha-2A adrenergic receptor ADRA2A 0.003
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.003
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.003
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6102 Arylamine N-acetyltransferase 2 NAT2 0.0027
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
23 D(1A) dopamine receptor DRD1 0.0027
54 Prothrombin F2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6147 Solute carrier family 22 member 3 SLC22A3 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
817 DNA topoisomerase 2-alpha TOP2A 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0026
427 Substance-P receptor TACR1 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0025
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
1541 Metalloproteinase mmp20 0.0025
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
94 5-hydroxytryptamine 4 receptor HTR4 0.0023
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0023
6182 Cytochrome P450 2J2 CYP2J2 0.0023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
407 Vascular endothelial growth factor receptor 2 KDR 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
153 Dopamine beta-hydroxylase DBH 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
6141 Sodium/bile acid cotransporter SLC10A1 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
777 Tumor necrosis factor TNF 0.0019
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
789 Alpha-1D adrenergic receptor ADRA1D 0.0018
869 Estrogen receptor beta ESR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0018
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0018
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0018
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0018
738 Monocarboxylate transporter 1 SLC16A1 0.0018
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0016
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
6014 Cytochrome P450 2A13 CYP2A13 0.0016
1648 Elastin ELN 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0015
1656 CYP2B protein CYP2B 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
833 Organic cation/carnitine transporter 1 SLC22A4 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
436 5-hydroxytryptamine 2B receptor HTR2B 0.0014
614 Progesterone receptor PGR 0.0014
629 Alpha-2B adrenergic receptor ADRA2B 0.0014
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0014
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0014
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0014
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0014
921 Glutamate receptor 2 GRIA2 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0014
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0014
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0014
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0014
2232 Interleukin-5 IL5 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0014
1593 Mucin-2 MUC2 0.0014
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0013
885 5-hydroxytryptamine 1B receptor HTR1B 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
124 Histamine H2 receptor HRH2 0.0012
193 Beta-1 adrenergic receptor ADRB1 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
518 Peroxidase/catalase T katG 0.0012
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0012
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
474 Acetylcholinesterase ACHE 0.0011
164 Histamine H4 receptor HRH4 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0011
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
638 D(3) dopamine receptor DRD3 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
432 D(4) dopamine receptor DRD4 0.0011
1629 Transcription factor AP-1 JUN 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
3809 Estrogen-related receptor gamma ESRRG 0.001
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
563 Thyroid peroxidase TPO 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.001
4122 Histone deacetylase 2 HDAC2 0.001
16 Adenosine A1 receptor ADORA1 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
716 5-hydroxytryptamine 7 receptor HTR7 0.0009
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0009
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
1192 Sulfotransferase 1A1 SULT1A1 0.0009
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0009
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
725 5-hydroxytryptamine 1D receptor HTR1D 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
26 Vascular endothelial growth factor receptor 3 FLT4 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
3830 Calreticulin CALR 0.0008
4773 Deoxycytidine kinase DCK 0.0008
161 Tubulin beta chain TUBB 0.0008
312 Tubulin beta chain TUB2 0.0008
1992 Vitamin D-binding protein GC 0.0007
3923 Cholinesterase BCHE 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1630 Integrin beta-2 ITGB2 0.0007
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
373 Transthyretin TTR 0.0007
1374 Natriuretic peptides B NPPB 0.0007
1827 Gap junction alpha-1 protein GJA1 0.0007
1908 Vascular cell adhesion protein 1 VCAM1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
4217 Telomerase reverse transcriptase TERT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
3947 Xanthine dehydrogenase/oxidase XDH 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
239 Coagulation factor X F10 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0006
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
378 Alpha-2C adrenergic receptor ADRA2C 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6044 Serum paraoxonase/lactonase 3 PON3 0.0006
3221 Cytochrome c4 cc4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0005
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0005
444 Alcohol dehydrogenase 1B ADH1B 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
7 Nitric oxide synthase, inducible NOS2 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1507 Cytochrome c CYCS 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
6218 Pannexin-1 PANX1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
1039 Histone deacetylase 9 HDAC9 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
936 Ephrin type-A receptor 2 EPHA2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
165 FL cytokine receptor FLT3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
3957 Adenosine deaminase ADA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
162 Retinoic acid receptor gamma-1 RARG 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
908 Glutathione S-transferase theta-1 GSTT1 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
469 Annexin A1 ANXA1 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
2207 Rhodopsin RHO 0.0003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
904 Glutathione S-transferase P GSTP1 0.0003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0003
489 Monocarboxylate transporter 2 SLC16A7 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0002
871 Glucocorticoid receptor NR3C1 0.0002
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
↑