DT-Web: DB00584

Identification

Name

Enalapril

Accession Number

DB00584 (APRD00510)

Type

small molecule

Description

Enalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

376.4467

Groups

approved

Monoisotopic Weight

376.199822016

Pharmacology

Indication

For the treatment of essential or renovascular hypertension and symptomatic congestive heart failure. It may be used alone or in combination with thiazide diuretics.

Mechanism of action

There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Enalaprilat, the principle active metabolite of enalapril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Enalapril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors. Enalaprilat's affinity for ACE is approximately 200,000 times greater than that of ATI and 300-1000 times greater than that enalapril.

Absorption

55-75%, absorption is unaffected by food; enalaprilat (clinically administered IV) is poorly absorbed, 3-12%, due to its high polarity.

Protein binding

50-60% of enalaprilat is bound to plasma proteins

Biotransformation

~ 60% of absorbed dose is extensively hydrolyzed to enalaprilat, primarily by liver esterases

Route of elimination

Excretion of enalapril is primarily renal.

Toxicity

Overdosage may result in marked hypotension and stupor. Most common adverse effects include hypotension, headache, dizziness and fatigue.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amiloride	Increased risk of hyperkalemia
Azilsartan medoxomil	Pharmacodynamic synergism: dual blockade of renin-angiotensin system. Increases risks of hypotension, hyperkalemia, renal impairment.
Drospirenone	Increased risk of hyperkalemia
Icatibant	Icatibant may attenuate the antihypertensive effect of ACE inhibitors by pharmacodynamic antagonism. Monitor concomitant therapy closely.
Insulin Lispro	Concomitant therapy with ACE inhibitors may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Lithium	The ACE inhibitor increases serum levels of lithium
Potassium	Increased risk of hyperkalemia
Rifampin	Rifampin, a strong CYP3A4 inducer, may increase the metabolism of enalapril. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of enalapril if rifampin is initiated, discontinued or dose changed.
Spironolactone	Increased risk of hyperkalemia
Tizanidine	Tizanidine increases the risk of hypotension with the ACE inhibitor
Tobramycin	Increased risk of nephrotoxicity
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triamterene	Increased risk of hyperkalemia

Food Interactions

Take without regard to meals.
Enalapril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
Herbs that may attenuate the antihypertensive effect of enalapril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
High salt intake may attenuate the antihypertensive effect of enalapril.

Angiotensin-converting enzyme
Name	Angiotensin-converting enzyme
Gene Name	ACE
Pharmacological action	yes
Actions	inhibitor
References	Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Liu YH, Liu LY, Wu JX, Chen SX, Sun YX: Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice. J Cardiovasc Pharmacol. 2006 Jan;47(1):82-8. - Pubmed Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. Biochemistry. 2004 Jul 13;43(27):8718-24. - Pubmed
DTHybrid score	0.5957

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4058

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed
DTHybrid score	0.3945
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions	substrate,inhibitor
References	Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadee W, Amidon GL: 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res. 1998 Aug;15(8):1154-9. - Pubmed Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. - Pubmed Temple CS, Boyd CA: Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter. Biochim Biophys Acta. 1998 Aug 14;1373(1):277-81. - Pubmed Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
DTHybrid score	0.5219
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed
DTHybrid score	0.4328
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score	0.3408
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score	0.2302
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate
References	Abu-Zahra TN, Wolkoff AW, Kim RB, Pang KS: Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6. - Pubmed Pang KS, Wang PJ, Chung AY, Wolkoff AW: The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. - Pubmed
DTHybrid score	0.261

Id	Partner name	Gene Name	Score
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.3686
1024	Solute carrier family 22 member 11	SLC22A11	0.1748
4757	Cytochrome P450 2C9	CYP2C9	0.145
587	Serum albumin	ALB	0.1422
4119	Cytochrome P450 2D6	CYP2D6	0.1373
6016	Cytochrome P450 2C19	CYP2C19	0.1287
4118	Cytochrome P450 3A5	CYP3A5	0.1273
4924	Cytochrome P450 2C8	CYP2C8	0.1212
4200	Cytochrome P450 1A2	CYP1A2	0.1107
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0969
118	Organic cation/carnitine transporter 2	SLC22A5	0.0949
6107	Cytochrome P450 3A7	CYP3A7	0.0908
1385	Angiotensin-converting enzyme 2	ACE2	0.0853
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0814
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0765
2164	Multidrug resistance-associated protein 4	ABCC4	0.0723
862	Multidrug resistance-associated protein 1	ABCC1	0.0719
633	Penicillin-binding proteins 1A/1B	pbpA	0.0699
20	Prostaglandin G/H synthase 1	PTGS1	0.0695
6030	Cytochrome P450 2B6	CYP2B6	0.0654
290	Prostaglandin G/H synthase 2	PTGS2	0.0648
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0628
6145	Solute carrier family 22 member 1	SLC22A1	0.0627
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0623
776	Bile salt export pump	ABCB11	0.0591
6013	Cytochrome P450 2E1	CYP2E1	0.0537
6024	Cytochrome P450 1A1	CYP1A1	0.053
6141	Sodium/bile acid cotransporter	SLC10A1	0.0521
6144	Solute carrier family 22 member 2	SLC22A2	0.049
3923	Cholinesterase	BCHE	0.0482
645	Penicillin-binding protein 1A	mrcA	0.0438
5805	Penicillin-binding protein 1A	ponA	0.0438
6185	Penicillin-binding protein 1A	mrcA	0.0438
6799	Penicillin-binding protein 1A	pbpA	0.0438
294	Neprilysin	MME	0.0432
4604	Liver carboxylesterase 1	CES1	0.0432
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0405
738	Monocarboxylate transporter 1	SLC16A1	0.0395
5718	Cytochrome P450 2A6	CYP2A6	0.0392
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0388
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0364
543	Penicillin-binding protein 1B	mrcB	0.0362
6186	Penicillin-binding protein 1B	ponB	0.0362
6822	Penicillin-binding protein 1b	pbp1b	0.0362
6844	Penicillin-binding protein 1b	pbp1b	0.0362
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0359
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0357
871	Glucocorticoid receptor	NR3C1	0.035
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.035
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0348
6136	Multidrug resistance-associated protein 5	ABCC5	0.0338
338	DNA polymerase	UL30	0.0337
379	DNA polymerase	UL54	0.0337
697	DNA polymerase	ORF28	0.0337
2482	DNA polymerase	43	0.0337
4104	DNA polymerase	BALF5	0.0337
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0332
1	Peptidoglycan synthetase ftsI	ftsI	0.0332
4155	Peptidoglycan synthetase ftsI	ftsI	0.0332
833	Organic cation/carnitine transporter 1	SLC22A4	0.033
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0315
3811	Cytochrome P450 19A1	CYP19A1	0.031
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0305
140	30S ribosomal protein S9	rpsI	0.0293
6719	30S ribosomal protein S9	rpsI	0.0293
6725	30S ribosomal protein S9	rpsI	0.0293
136	Estrogen receptor	ESR1	0.0292
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0291
22	30S ribosomal protein S4	rpsD	0.0286
6714	30S ribosomal protein S4	rpsD	0.0286
492	Histamine H1 receptor	HRH1	0.0263
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0261
556	Alpha-1A adrenergic receptor	ADRA1A	0.0248
1898	Cytochrome P450 1B1	CYP1B1	0.0241
6106	Cytochrome P450 2C18	CYP2C18	0.0238
6020	Aldehyde oxidase	AOX1	0.0231
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0231
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0229
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0228
6702	Organic hydroperoxide resistance protein, putative	VC_A1006	0.0228
4587	Carbapenem-hydrolyzing beta-lactamase blaB-1	blaB1	0.0228
4586	FEZ-1 protein	blaFEZ-1	0.0228
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0227
65	Matrix metalloproteinase-9	Not Available	0.0226
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0224
6148	Multidrug resistance-associated protein 7	ABCC10	0.0224
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.022
6147	Solute carrier family 22 member 3	SLC22A3	0.0214
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0212
3947	Xanthine dehydrogenase/oxidase	XDH	0.0206
731	HIV-1 protease	HIV-1 protease	0.0204
707	72 kDa type IV collagenase	MMP2	0.0203
2016	Dipeptidase 1	DPEP1	0.0197
318	Alpha-2A adrenergic receptor	ADRA2A	0.0196
404	DNA gyrase subunit A	gyrA	0.0193
6224	DNA gyrase subunit A	gyrA	0.0193
33	Cystine/glutamate transporter	SLC7A11	0.0192
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0191
756	Sex hormone-binding globulin	SHBG	0.0189
824	Sodium-dependent serotonin transporter	SLC6A4	0.0185
831	D(2) dopamine receptor	DRD2	0.0181
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.018
146	Androgen receptor	AR	0.018
5353	Glutamate decarboxylase alpha	gadA	0.0178
6149	Solute carrier family 22 member 10	SLC22A10	0.0176
6031	Cytochrome P450 3A43	CYP3A43	0.0176
1757	Myeloperoxidase	MPO	0.0174
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0173
592	Carbonic anhydrase 4	CA4	0.0173
632	Alpha-1B adrenergic receptor	ADRA1B	0.0171
6167	Organic solute transporter subunit beta	OSTB	0.017
6166	Organic solute transporter subunit alpha	OSTA	0.017
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.017
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.017
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0169
124	Histamine H2 receptor	HRH2	0.0168
3587	Gastrotropin	FABP6	0.0166
295	Carbonic anhydrase 1	CA1	0.0163
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0161
357	Carbonic anhydrase 2	CA2	0.0155
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0155
373	Transthyretin	TTR	0.0154
847	Mu-type opioid receptor	OPRM1	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
558	Solute carrier family 12 member 1	SLC12A1	0.0148
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0148
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0147
817	DNA topoisomerase 2-alpha	TOP2A	0.0145
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
1867	Major prion protein	PRNP	0.0144
5754	Metallo-beta-lactamase L1	Not Available	0.0143
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0142
904	Glutathione S-transferase P	GSTP1	0.0142
4237	50S ribosomal protein L22	rplV	0.0141
103	Muscarinic acetylcholine receptor M1	CHRM1	0.014
6137	Multidrug resistance-associated protein 6	ABCC6	0.014
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0139
3626	Probable polysaccharide deacetylase pdaA	pdaA	0.0138
818	50S ribosomal protein L10	rplJ	0.0138
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0136
6033	High affinity interleukin-8 receptor A	CXCR1	0.0135
869	Estrogen receptor beta	ESR2	0.0135
4238	50S ribosomal protein L4	rplD	0.0134
5578	50S ribosomal protein L4	rplD	0.0134
6173	50S ribosomal protein L4	rplD	0.0134
6219	50S ribosomal protein L4	rplD	0.0134
474	Acetylcholinesterase	ACHE	0.0133
5626	Nucleoside diphosphate kinase B	NME2	0.0132
467	Delta-type opioid receptor	OPRD1	0.0132
232	Corticosteroid-binding globulin	SERPINA6	0.0131
867	Penicillin-binding protein 3	pbpC	0.013
6119	Penicillin-binding protein 3	pbp3	0.013
7154	Penicillin-binding protein 3	pbp3	0.013
7157	Penicillin-binding protein 3	LMHCC_2184	0.013
7162	Penicillin-binding protein 3	pbpB	0.013
7172	Penicillin-binding protein 3	pbp3	0.013
3810	Catechol O-methyltransferase	COMT	0.0129
3685	Catabolite gene activator	crp	0.0127
4655	Adenylate cyclase	cyaC	0.0127
4759	Adenylate cyclase	cyaB2	0.0127
193	Beta-1 adrenergic receptor	ADRB1	0.0127
3639	Thymidine phosphorylase	deoA	0.0127
3936	Thymidine phosphorylase	TYMP	0.0127
4787	Envelope glycoprotein gp160	env	0.0125
4820	Envelope glycoprotein gp160	env	0.0125
5727	Envelope glycoprotein gp160	env	0.0125
737	Mineralocorticoid receptor	NR3C2	0.0125
6207	30S ribosomal protein S14	rpsN	0.0124
6209	30S ribosomal protein S19	rpsS	0.0124
6712	30S ribosomal protein S19	rpsS	0.0124
6726	30S ribosomal protein S19	rpsS	0.0124
260	Cytochrome P450 51	ERG11	0.0124
761	Cytochrome P450 51	ERG11	0.0124
3163	Cytochrome P450 51	cyp51	0.0124
23	D(1A) dopamine receptor	DRD1	0.0124
3941	Amine oxidase [flavin-containing] A	MAOA	0.0124
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
438	Taste receptor type 1 member 2	TAS1R2	0.0122
4122	Histone deacetylase 2	HDAC2	0.0121
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0121
723	Cytosolic phospholipase A2	PLA2G4A	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0119
766	Beta-2 adrenergic receptor	ADRB2	0.0118
477	DNA topoisomerase 4 subunit A	parC	0.0118
886	DNA topoisomerase 4 subunit A	parC	0.0118
6226	DNA topoisomerase 4 subunit A	parC	0.0118
1141	Sialidase-1	NEU1	0.0117
64	Neuraminidase	NA	0.0117
641	Neuraminidase	NA	0.0117
2676	Neuraminidase	NA	0.0117
3026	Neuraminidase	NA	0.0117
3519	Neuraminidase	NA	0.0117
6007	Neuraminidase	NA	0.0117
594	Thyroxine-binding globulin	SERPINA7	0.0115
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0115
952	Dipeptidyl peptidase 4	DPP4	0.0115
1373	Glucosylceramidase	GBA	0.0114
4666	Fucose-binding lectin PA-IIL	lecB	0.0114
696	Kappa-type opioid receptor	OPRK1	0.0114
24	Thymidylate synthase	TMP1	0.0113
359	Thymidylate synthase	TYMS	0.0113
2626	Thymidylate synthase	thyA	0.0113
2729	Thymidylate synthase	thyA	0.0113
5352	Thymidylate synthase	THYA	0.0113
53	Solute carrier family 12 member 5	SLC12A5	0.0113
663	Solute carrier family 12 member 4	SLC12A4	0.0113
380	Cytochrome P450 17A1	CYP17A1	0.0112
3686	Acyl-CoA thioesterase I precursor	tesA	0.0111
2249	Aspartate aminotransferase	aspC	0.011
2671	Aspartate aminotransferase	aspC	0.011
5490	Aspartate aminotransferase	Not Available	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
275	Arachidonate 5-lipoxygenase	ALOX5	0.011
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0109
4760	Mll3241 protein	mll3241	0.0109
2320	Thymidine kinase, cytosolic	TK1	0.0108
115	Penicillin-binding protein 2	mrdA	0.0108
6069	Penicillin-binding protein 2	mrdA	0.0108
6118	Penicillin-binding protein 2	penA	0.0108
6187	Penicillin-binding protein 2	pbpA	0.0108
6686	Penicillin-binding protein 2	pbp2	0.0108
6939	Penicillin-binding protein 2	mrdA	0.0108
7163	Penicillin-binding protein 2	pbpA	0.0108
3760	Penicillin-binding protein 5 precursor	dacA	0.0108
5294	Nucleoside diphosphate kinase A	NME1	0.0107
6067	Penicillin binding protein 2a	mecA	0.0107
509	Thymidine kinase	TK	0.0106
570	Thymidine kinase	TK	0.0106
2559	Thymidine kinase	TK	0.0106
3430	Thymidine kinase	tdk	0.0106
3518	Thymidine kinase	TK	0.0106
5301	Thymidine kinase	tdk	0.0106
5771	Thymidine kinase	ORF36	0.0106
7009	Thymidine kinase	ORF36	0.0106
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0106
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0106
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0106
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0106
758	Thyroid hormone receptor alpha	THRA	0.0106
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0106
310	Solute carrier family 12 member 2	SLC12A2	0.0105
1178	Adenosine A2a receptor	ADORA2A	0.0104
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0104
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0104
3140	Hemagglutinin-neuraminidase	HN	0.0104
3609	Hemagglutinin-neuraminidase	HN	0.0104
468	Cytochrome P450 4A11	CYP4A11	0.0103
6043	Putative G-protein coupled receptor 44	GPR44	0.0103
614	Progesterone receptor	PGR	0.0103
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0102
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0102
527	Prostacyclin receptor	PTGIR	0.01
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0099
887	DNA gyrase subunit B	gyrB	0.0099
4150	DNA gyrase subunit B	gyrB	0.0099
6225	DNA gyrase subunit B	gyrB	0.0099
3426	Glutamine synthetase	glnA	0.0098
3987	Glutamine synthetase	GLUL	0.0098
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0098
672	Prostaglandin F2-alpha receptor	PTGFR	0.0098
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
789	Alpha-1D adrenergic receptor	ADRA1D	0.0097
16	Adenosine A1 receptor	ADORA1	0.0097
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0095
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0095
346	Thyroid hormone receptor beta-1	THRB	0.0095
6126	Carbonic anhydrase 7	CA7	0.0094
638	D(3) dopamine receptor	DRD3	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0092
2544	Bacterial leucyl aminopeptidase	Not Available	0.0092
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0091
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0091
5482	Sialidase-2	NEU2	0.0091
29	Tubulin beta-1 chain	TUBB1	0.0091
1654	Interleukin-1 beta	IL1B	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
274	Muscarinic acetylcholine receptor M5	CHRM5	0.009
6182	Cytochrome P450 2J2	CYP2J2	0.0088
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0088
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0088
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0088
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0086
183	Vascular endothelial growth factor A	VEGFA	0.0086
4773	Deoxycytidine kinase	DCK	0.0086
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0084
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0084
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0084
159	Penicillin-binding protein 2B	penA	0.0084
6121	Penicillin-binding protein 2B	penA	0.0084
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0083
4252	Penicillin-binding protein 5	dacA	0.0082
6113	MecA PBP2' (penicillin binding protein 2')	mecA	0.0082
6014	Cytochrome P450 2A13	CYP2A13	0.0082
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0081
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.008
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0079
332	Beta-lactamase	blaZ	0.0079
2478	Beta-lactamase	ampC	0.0079
2613	Beta-lactamase	ampC	0.0079
2635	Beta-lactamase	ampC	0.0079
2700	Beta-lactamase	penP	0.0079
5445	Beta-lactamase	blaB	0.0079
6019	Beta-lactamase	SHV-7	0.0079
6701	Beta-lactamase	cphA	0.0079
273	Apoptosis regulator Bcl-2	BCL2	0.0078
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0078
4217	Telomerase reverse transcriptase	TERT	0.0077
465	Calmodulin	CALM1	0.0077
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0077
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0076
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0075
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0075
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0075
4785	Ig gamma-1 chain C region	IGHG1	0.0074
6151	Monocarboxylate transporter 10	SLC16A10	0.0074
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0074
629	Alpha-2B adrenergic receptor	ADRA2B	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0074
494	Caspase-1	CASP1	0.0073
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0073
844	Epidermal growth factor receptor	EGFR	0.0073
161	Tubulin beta chain	TUBB	0.0073
312	Tubulin beta chain	TUB2	0.0073
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0073
6085	Fatty acid-binding protein, intestinal	FABP2	0.0073
122	P2Y purinoceptor 12	P2RY12	0.0072
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0072
1852	Microtubule-associated protein 2	MAP2	0.0071
1192	Sulfotransferase 1A1	SULT1A1	0.0071
1507	Cytochrome c	CYCS	0.007
713	Sodium-dependent dopamine transporter	SLC6A3	0.0069
3060	Leukotriene A-4 hydrolase	LTA4H	0.0069
293	Gamma-glutamyl hydrolase	GGH	0.0069
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0069
130	Prostacyclin synthase	PTGIS	0.0068
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0068
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
6218	Pannexin-1	PANX1	0.0067
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0067
432	D(4) dopamine receptor	DRD4	0.0066
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0066
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0065
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
378	Alpha-2C adrenergic receptor	ADRA2C	0.0063
1353	DNA topoisomerase 1	TOP1	0.0063
3552	DNA topoisomerase 1	topA	0.0063
70	Type-1 angiotensin II receptor	AGTR1	0.0062
4120	NADPH--cytochrome P450 reductase	POR	0.0062
3932	Glutathione S-transferase A2	GSTA2	0.0062
199	Monocarboxylate transporter 8	SLC16A2	0.0062
2077	Caspase-3	CASP3	0.0061
284	DNA-directed RNA polymerase beta chain	rpoB	0.0061
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0061
1405	Thiopurine S-methyltransferase	TPMT	0.0061
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
1650	Heme carrier protein 1	SLC46A1	0.0061
469	Annexin A1	ANXA1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0059
819	Penicillin-binding protein 4	dacB	0.0059
1517	Beta-3 adrenergic receptor	ADRB3	0.0059
504	Mast/stem cell growth factor receptor	KIT	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0058
5818	Folate receptor alpha	FOLR1	0.0058
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0057
6042	Prostaglandin reductase 2	PTGR2	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0054
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0053
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0053
365	Dihydrofolate reductase	DHFR	0.0053
2381	Dihydrofolate reductase	DFR1	0.0053
2833	Dihydrofolate reductase	Not Available	0.0053
2931	Dihydrofolate reductase	folA	0.0053
3544	Dihydrofolate reductase	folA	0.0053
3682	Dihydrofolate reductase	folA	0.0053
6642	Dihydrofolate reductase	folA	0.0053
6756	Dihydrofolate reductase	dfrA	0.0053
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0052
163	D(1B) dopamine receptor	DRD5	0.0052
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0052
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0052
407	Vascular endothelial growth factor receptor 2	KDR	0.0051
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0051
716	5-hydroxytryptamine 7 receptor	HTR7	0.0051
2021	Thrombomodulin	THBD	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
5924	Microtubule-associated protein 4	MAP4	0.005
5923	Microtubule-associated protein tau	MAPT	0.005
1198	Serum paraoxonase/arylesterase 1	PON1	0.005
6223	Penicillin-binding protein 1C	pbpC	0.005
777	Tumor necrosis factor	TNF	0.005
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.005
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0049
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0049
1039	Histone deacetylase 9	HDAC9	0.0048
26	Vascular endothelial growth factor receptor 3	FLT4	0.0047
489	Monocarboxylate transporter 2	SLC16A7	0.0047
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0047
1291	cAMP response element-binding protein	CREB1	0.0047
3939	Amine oxidase [flavin-containing] B	MAOB	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
2391	Ferrochelatase	hemH	0.0046
6502	Ferrochelatase	DKFZp686P18130	0.0046
1591	Ferrochelatase, mitochondrial	FECH	0.0046
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0046
4210	Toll-like receptor 4	TLR4	0.0046
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0046
32	Vascular endothelial growth factor receptor 1	FLT1	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
811	Translocator protein	TSPO	0.0044
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0044
6131	Carbonic anhydrase 14	CA14	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0044
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0044
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0044
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0044
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0044
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0044
1313	Lactoylglutathione lyase	GLO1	0.0044
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0044
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0044
3809	Estrogen-related receptor gamma	ESRRG	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0042
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0042
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0042
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0042
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0042
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
1010	Cytochrome P450 51A1	CYP51A1	0.0041
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6122	Carbonic anhydrase 3	CA3	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
408	Riboflavin kinase	RFK	0.0041
1656	CYP2B protein	CYP2B	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.004
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.004
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.004
6493	Cytochrome c oxidase subunit 6C	COX6C	0.004
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.004
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.004
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.004
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.004
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.004
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.004
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.004
6559	Cytochrome c oxidase subunit 2	ctaC	0.004
6669	Cytochrome c oxidase subunit 2	ctaC	0.004
371	Cytochrome c oxidase subunit 1	MT-CO1	0.004
6558	Cytochrome c oxidase subunit 1	ctaD	0.004
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.004
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0039
6220	Aryl hydrocarbon receptor	AHR	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0038
2539	Tubulin alpha-1 chain	TUBA4A	0.0037
2540	Choloylglycine hydrolase	cbh	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0037
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0037
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0036
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
856	Vitamin D3 receptor	VDR	0.0035
1792	Tissue-type plasminogen activator	PLAT	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6171	Solute carrier family 28 member 3	SLC28A3	0.0035
1630	Integrin beta-2	ITGB2	0.0035
1025	Aquaporin-1	AQP1	0.0035
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6501	Fatty acid-binding protein, liver	FABP1	0.0035
751	Potassium channel subfamily K member 6	KCNK6	0.0035
3007	Carbonic anhydrase 12	CA12	0.0034
4205	Carbonic anhydrase 9	CA9	0.0034
976	Platelet glycoprotein IX	GP9	0.0034
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0034
4226	Uridine phosphorylase 2	UPP2	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0033
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0033
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0033
268	Adenosine A2b receptor	ADORA2B	0.0033
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0032
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0032
6102	Arylamine N-acetyltransferase 2	NAT2	0.0032
172	Potassium channel subfamily K member 1	KCNK1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
3957	Adenosine deaminase	ADA	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.003
4225	Uridine phosphorylase 1	UPP1	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
239	Coagulation factor X	F10	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
654	Flavin reductase	BLVRB	0.0029
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0029
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0029
413	Amidophosphoribosyltransferase	PPAT	0.0029
2515	Amidophosphoribosyltransferase	purF	0.0029
3714	Amidophosphoribosyltransferase	purF	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
1629	Transcription factor AP-1	JUN	0.0029
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0029
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0029
319	Opioid receptor, sigma 1	OPRS1	0.0028
571	Melatonin receptor type 1A	MTNR1A	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
362	Melatonin receptor type 1B	MTNR1B	0.0028
517	Alcohol dehydrogenase 1C	ADH1C	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
1196	Complement decay-accelerating factor	CD55	0.0027
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0027
5126	Arginase	rocF	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
6168	Solute carrier family 22 member 16	SLC22A16	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2300	Lysozyme	E	0.0027
3633	Lysozyme	R	0.0027
5597	Lysozyme	17	0.0027
702	UMP-CMP kinase	CMPK1	0.0027
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0027
572	Integrin alpha-L	ITGAL	0.0026
6824	Tyrosine-protein kinase Lyn	LYN	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0026
49	Endothelin B receptor	EDNRB	0.0026
427	Substance-P receptor	TACR1	0.0026
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2808	Chloramphenicol acetyltransferase 3	cat3	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
165	FL cytokine receptor	FLT3	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0023
84	Nuclear receptor 0B1	NR0B1	0.0023
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0023
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
5934	Cytochrome P450 26A1	CYP26A1	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0022
2417	Chloramphenicol acetyltransferase	cat	0.0022
3278	Chloramphenicol acetyltransferase	cat	0.0022
2810	Dr hemagglutinin structural subunit	draA	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
6432	Transporter	snf	0.002
4203	Histamine N-methyltransferase	HNMT	0.002
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
7	Nitric oxide synthase, inducible	NOS2	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
5787	Angiopoietin-1 receptor	TEK	0.0019
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
54	Prothrombin	F2	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0018
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1275	Estrogen sulfotransferase	SULT1E1	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
6755	Poliovirus receptor	PVR	0.0015
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0015
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0015
634	Squalene monooxygenase	SQLE	0.0015
7196	Squalene monooxygenase	ERG1	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
822	Aldose reductase	AKR1B1	0.0014
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
823	Fibroblast growth factor receptor 2	FGFR2	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
921	Glutamate receptor 2	GRIA2	0.0013
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
1295	Fatty acid synthase	FASN	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
2236	Casein kinase II subunit alpha	CSNK2A1	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
4311	tRNA	TRDMT1	0.0011
4325	tRNA	trmD	0.0011
4328	tRNA	trmD	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
997	Protein kinase C beta type	PRKCB	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
162	Retinoic acid receptor gamma-1	RARG	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
164	Histamine H4 receptor	HRH4	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1864	RET proto-oncogene	RET	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00584 - Enalapril

Targets

Enzymes

Transporters

Predictions