DT-Web: DB01045

Identification

Name

Rifampin

Accession Number

DB01045 (APRD00207, EXPT02777)

Type

small molecule

Description

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

822.9402

Groups

approved

Monoisotopic Weight

822.40512334

Pharmacology

Indication

For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Mechanism of action

Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Absorption

Well absorbed from gastrointestinal tract.

Protein binding

89%

Biotransformation

Primarily hepatic, rapidly deacetylated.

Route of elimination

Less than 30% of the dose is excreted in the urine as rifampin or metabolites.

Toxicity

LD₅₀=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness

Affected organisms

Mycobacteria
Various gram-negative and gram-positive eubacteria

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol	Rifampin may decrease the anticoagulant effect of acenocoumarol by increasing its metabolism.
Acetohexamide	Rifampin may decrease the effect of sulfonylurea, acetohexamide.
Alfentanil	Rifampin reduces levels and efficacy of alfentanil
Aminophylline	Rifampin decreases the effect of theophylline
Amiodarone	Rifampin decreases the effect of amiodarone
Amitriptyline	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, amitriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if rifampin is initiated, discontinued or dose changed.
Amoxapine	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, amoxapine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if rifampin is initiated, discontinued or dose changed.
Amprenavir	In presence of rifampin anticipate decrease of amprenavir efficiency
Anisindione	Rifampin may decrease the anticoagulant effect of anisindione.
Aprepitant	The CYP3A4 inducer, rifampin, may decrease the effect of aprepitant.
Artemether	Oral administration of rifampin, a strong CYP3A4 inducer, with Coartem Tablets resulted in significant decreases in exposure to artemether, dihydroartemisinin (DHA, metabolite of artemether) and lumefantrine by 89%, 85% and 68%, respectively, when compared to exposure values after Coartem Tablets alone. Concomitant use of strong inducers of CYP3A4 such as rifampin, carbamazepine, phenytoin and St. John's wort is contraindicated with Coartem Tablets.
Atazanavir	Rifampin reduces levels and efficacy of atazanavir
Atorvastatin	Rifampin may decrease the effect of atorvastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of atorvastatin if rifampin is initiated, discontinued or dose changed.
Atovaquone	Rifampin may decrease the effect of atovaquone.
Bedaquiline	Strong CYP3A4 inducers may decrease exposure of bedaquiline. Co-administration should be avoided.
Bendamustine	CYP1A2 metabolism may result in increased levels of active metabolites, decreases levels of bendamustine.
Betamethasone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, betamethasone.
Bisoprolol	Rifampin may decrease the serum concentration of bisprolol by increasing its metabolism.
Boceprevir	Strong CYP3A4 inducers will decrease levels of boceprevir. Concomitant therapy is contraindicated.
Bosutinib	Strong CYP3A4 inducers may decrease levels of bosutinib. Monitor concomitant therapy closely.
Bromazepam	Rifampin may decrease the serum concentration of bromazepam by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if rifampin is initiated, discontinued or dose changed.
Bupropion	Rifampin reduces bupropion levels
Buspirone	Rifampin decreases the effect of buspirone
Cabazitaxel	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Canagliflozin	Nonselective inducers of UGT enzymes may decrease levels of canagliflozin, thus decreasing efficacy. Consider increase the dose to 300 mg once daily.
Caspofungin	Decreased levels/effects of caspofungin
Celecoxib	Rifampin, a strong CYP2C9 inducer, may decrease the serum levels of celecoxib by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects if rifampin is initiated, discontinued or dose changed.
Cerivastatin	Rifampin may decrease the effect of cerivastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of cerivastatin if rifampin is initiated, discontinued or dose changed.
Chloramphenicol	Rifampin decreases the effect of chloramphenicol
Chlorpropamide	Rifampin may decrease the effect of sulfonylurea, chlorpropamide.
Clarithromycin	The rifamycin, rifampin, may decrease the effect of the macrolide, clarithromycin.
Clomipramine	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, clomipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if rifampin is initiated, discontinued or dose changed.
Clozapine	Rifampin decreases the effect of clozapine
Cortisone acetate	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, cortisone acetate.
Crizotinib	Strong CYP3A4 inducers may decrease levels of crizotinib. Monitor concomitant therapy closely.
Crizotinib	Strong CYP3A4 inducers may decrease levels of crizotinib. Monitor concomitant therapy closely.
Cyclosporine	The rifamycin decreases the effect of cyclosporine
Dabigatran etexilate	P-Glycoprotein inducers such as rifampin may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dabrafenib	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Dapsone	Decreased levels of dapsone
Dasatinib	Rifampin may decrease the serum level and efficacy of dasatinib.
Delavirdine	Rifampin decreases the effect of delavirdine
Desipramine	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, desipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if rifampin is initiated, discontinued or dose changed.
Dexamethasone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, dexamethasone.
Diazepam	Rifampin may decrease the effect of the benzodiazepine, diazepam.
Diclofenac	Rifampin, a CYP2C9 inducer, may increase the metabolism of diclofenac.
Dicumarol	Rifampin may decrease the anticoagulant effect of dicumarol.
Diltiazem	Rifampin decreases levels of diltiazem
Disopyramide	Rifampin decreases the effect of disopyramide
Doxepin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, doxepin, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if rifampin is initiated, discontinued or dose changed.
Doxycycline	The rifamycin decreases the effect of doxycycline
Dyphylline	Rifampin decreases the effect of theophylline
Enalapril	Rifampin, a strong CYP3A4 inducer, may increase the metabolism of enalapril. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of enalapril if rifampin is initiated, discontinued or dose changed.
Erlotinib	Decreased levels/effect of erlotinib
Erythromycin	The rifamycin, rifampin, may decrease the effect of the macrolide, erythromycin.
Ethinyl Estradiol	This product may cause a slight decrease of contraceptive effect
Ethotoin	Rifampin decreases the effect of the hydantoin
Etoricoxib	Rifampin reduces levels and efficacy of etoricoxib
Fentanyl	Rifampin may decrease the serum level and therapeutic effect of fentanyl.
Fluconazole	Rifampin may decrease the effect of fluconazole.
Fludrocortisone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, fludrocortisone.
Fluvastatin	Rifampin may decrease the effect of fluvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of fluvastatin if rifampin is initiated, discontinued or dose changed.
Fosamprenavir	Rifampin may decrease the effectiveness of fosamprenavir.
Fosphenytoin	Rifampin may decrease the effect of fosphenytoin.
Gadoxetate	Substrates of OATP1B1 and OATP1B3 may limit uptake of gadoxetate disodium into heptatocytes. This may alter the intensity of the signal.
Gefitinib	Rifampin reduces levels and efficacy of gefitinib
Gliclazide	Rifampin may decrease the effect of sulfonylurea, gliclazide.
Glimepiride	Rifampin may decrease the effect of sulfonylurea, glimepiride.
Glipizide	Rifampin may decrease the effect of sulfonylurea, glipizide.
Glisoxepide	Rifampin may decrease the effect of sulfonylurea, glisoxepide.
Glyburide	Rifampin may decrease the effect of sulfonylurea, glibenclamide.
Glycodiazine	Rifampin may decrease the effect of sulfonylurea, glycodiazine.
Haloperidol	The rifamycin decreases the effect of haloperidol
Hydrocortisone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, hydrocortisone.
Imatinib	Rifampin decreases levels of imatinib
Imipramine	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, imipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if rifampin is initiated, discontinued or dose changed.
Indinavir	Rifampin decreases the effect of indinavir
Itraconazole	Rifampin may decrease the effect of itraconazole.
Ivacaftor	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Josamycin	The rifamycin, rifampin, may decrease the effect of the macrolide, josamycin.
Ketoconazole	Rifampin may decrease the effect of ketoconazole.
Lamotrigine	Rifampin decreases levels of lamotrigine
Leflunomide	Rifampin increases the effect of leflunomide
Linagliptin	CYP3A4 and p-glycoprotein inducers may decreases levels of linagliptin. Monitor concomitant therapy closely.
Losartan	Rifampin decreases the effect of losartan
Lovastatin	Rifampin may decrease the effect of lovastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of lovastatin if rifampin is initiated, discontinued or dose changed.
Mefloquine	Rifampin lowers mefloquine levels
Mephenytoin	Rifampin decreases the effect of the hydantoin
Mestranol	This product may cause a slight decrease of contraceptive effect
Methadone	The rifamycin decreases the effect of methadone
Methylprednisolone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, methylprednisolone.
Metoprolol	Rifampin may decrease the serum concentration of metoprolol by increasing its metabolism.
Mexiletine	Rifampin decreases the effect of mexiletine
Midazolam	Rifampin may increase the metabolism of midazolam. Monitor for changes in the therapeutic and adverse effects of midazolam if rifampin is initiated, discontinued or dose changed.
Mirabegron	Strong CYP3A4 inducers may decrease levels of mirabegron. Monitor concomitant therapy closely.
Morphine	Rifampin decreases the effect of morphine/codeine
Mycophenolate mofetil	Rifampin may decrease the serum concentration of mycophenolate. Concomitant therapy should be avoided.
Nelfinavir	Rifampin decreases the effect of nelfinavir
Nifedipine	Rifampin decreases the effect of the calcium channel blocker, nifedipine.
Norethindrone	This product may cause a slight decrease of contraceptive effect
Nortriptyline	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, nortriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if rifampin is initiated, discontinued or dose changed.
Ospemifene	Rifampin, a strong CYP3A4 / moderate CYP2C9 / moderate CYP2C19 inducer, decreases the systemic exposure of ospemifene by 58%. Therefore, co-administration of ospemifene with drugs such as rifampin which induce CYP3A4, CYP2C9 and/or CYP2C19 activity would be expected to decrease the systemic exposure of ospemifene, which may decrease the clinical effect.
Oxtriphylline	Rifampin may decrease the effect and toxicity of oxtriphylline.
Paramethasone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, paramethasone.
Pazopanib	Concomitant therapy with a CYP3A4 inducer may decrease exposure of pazopanib.
Phenytoin	Rifampin may decrease the therapeutic and adverse effects of phenytoin.
Pitavastatin	Rifampin significantly increased pitavastatin exposure. In patients taking rifampin, a dose of LIVALO 2 mg once daily should not be exceeded.
Pitavastatin	Rifampin significantly increased pitavastatin exposure. In patients taking rifampin, a dose of LIVALO 2 mg once daily should not be exceeded.
Pomalidomide	Strong CYP3A4 inducers may decrease levels of pomalidomide. Concomitant therapy should be avoided.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Praziquantel	Significant decrease in praziquantel level
Prednisolone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, prednisolone.
Prednisone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, prednisone.
Propafenone	Rifampin decreases the effect of propafenone
Propranolol	Rifampin may decrease the serum concentration of propranolol by increasing its metabolism.
Protriptyline	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, protriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if rifampin is initiated, discontinued or dose changed.
Quinidine	Rifampin decreases the effect of quinidine
Quinidine barbiturate	Rifampin decreases the effect of quinidine
Ramelteon	Rifampin reduces the levels/effect of ramelteon
Regorafenib	Strong CYP3A4 inducers may decrease levels of regorafenib.
Repaglinide	Rifampin decreases the effect of repaglinide
Rilpivirine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Ritonavir	Rifampin decreases the effect of ritonavir
Roflumilast	Affects CYP3A4 metabolism, decreases level or effect of roflumilast. Also decreases the level or effect of roflumilast by affecting CYP1A2 metabolism.
Rosiglitazone	Rifampin reduces levels and efficacy of rosiglitazone
Ruxolitinib	Strong CYP3A4 inducers may decrease levels of ruxolitinib. Closely monitor patient.
Saquinavir	Rifampin decreases the effect of saquinavir
Saxagliptin	Rifampin is a strong inducer of CYP3A4 which decreases exposure of saxagliptin. The exposure of the active metabolite, 5-hydroxy saxagliptin, also increases.
Simvastatin	Rifampin may decrease the effect of simvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if rifampin is initiated, discontinued or dose changed.
Sirolimus	The rifamycin decreases the effect of sirolimus
Sunitinib	Possible decrease in sunitinib levels
Tacrolimus	Rifampin may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Rifampin therapy is initiated, discontinued or altered.
Tadalafil	Rifampin may reduce Tadalafil plasma concentrations and efficacy.
Tamoxifen	The rifamycin decreases the effect of anti-estrogen
Telaprevir	Strong CYP3A4 inducers will decrease levels of telaprevir. Concomitant therapy is contraindicated.
Telithromycin	Rifampin may decrease the plasma concentration of Telithromycin. Concomitant therapy should be avoided.
Temsirolimus	Rifampin may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Terbinafine	Rifampin may increase the metabolism and clearance of Terbinafine. Co-administration may result in Terbinafine treatment failure.
Theophylline	Rifampin decreases the effect of theophylline
Tipranavir	Rifampin may decrease the plasma concentration of Tipranavir. Concomitant use is not recommended.
Tocainide	Rifampin lowers tocainide levels/effects
Tofacitinib	Rifampin (and other potent CYP3A4 inducers), when used in combination with tofacitinib, may decrease tofacitinib toxicity.
Tolazamide	Rifampin may decrease the effect of sulfonylurea, tolazamide.
Tolbutamide	Rifampin may decrease the effect of sulfonylurea, tolbutamide.
Tolvaptan	Rifampin is a CYP3A4 inducer and will decrease serum concentrations of tolvaptan and ultimately, its clinical effects.
Toremifene	The rifamycin decreases the effect of anti-estrogen
Tramadol	Rifampin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inducer, Rifampin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Rifampin is initiated, discontinued or dose changed.
Tretinoin	The strong CYP2C8 inducer, Rifampin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rifampin is initiated, discontinued or dose changed.
Triamcinolone	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, triamcinolone.
Triazolam	Rifampin may decrease the effect of the benzodiazepine, triazolam.
Trimethoprim	Rifampin decreases the effect of trimethoprim
Trimipramine	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, trimipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trimipramine if rifampin is initiated, discontinued or dose changed.
Ulipristal	Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Valproic Acid	Rifampin may reduce the serum concentration of Valproic acid by increasing Valproic acid metabolism. Valproic acid dose adjustments may be required during concomitant therapy. Monitor Valproic acid serum concentrations, efficacy and toxicity if Rifampin is initiated, discontinued or dose changed.
Vandetanib	Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vemurafenib	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Verapamil	Rifampin, a CYP3A4 inducer, may decrease the serum concentration of Verapamil by increasing its metabolism (particularly in the intestinal mucosa) and decreasing its absorption. Monitor for changes in the therapeutic/adverse effects of Verapamil if Rifampin is initiated, discontinued or dose changed.
Voriconazole	Rifampin may decrease the serum concentration of voriconazole likely by increasing its metabolism via CYP3A enzymes. Voriconazole may increase the serum concentration of rifampin likely by inhibiting its metabolism via CYP3A. Concomitant therapy is contraindicated.
Warfarin	Rifampin may decrease the anticoagulant effect of warfarin by increasing its metabolism.
Zaleplon	Rifampin decreases the effect of zaleplon
Zidovudine	Rifampin may decrease the serum concentration of zidovudine by increasing its metabolism. Monitor for changes in the serum concentration and therapeutic and adverse effects of zidovudine if rifampin is initiated, discontinued or dose changed.

Food Interactions

Take on empty stomach: 1 hour before or 2 hours after meals.
Avoid alcohol.
Take with a full glass of water.

DNA-directed RNA polymerase beta chain
Name	DNA-directed RNA polymerase beta chain
Gene Name	rpoB
Pharmacological action	yes
Actions	inhibitor
References	Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. - Pubmed White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. - Pubmed Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. Epub 2010 Feb 24. - Pubmed Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. - Pubmed Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. - Pubmed
DTHybrid score	0.5243
DNA-directed RNA polymerase subunit beta'
Name	DNA-directed RNA polymerase subunit beta'
Gene Name	rpoC
Pharmacological action	yes
Actions	inhibitor
References	Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. - Pubmed White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. - Pubmed Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. Epub 2010 Feb 24. - Pubmed Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. - Pubmed Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. - Pubmed
DTHybrid score	Not Available
Nuclear receptor subfamily 1 group I member 2
Name	Nuclear receptor subfamily 1 group I member 2
Gene Name	NR1I2
Pharmacological action	unknown
Actions	agonist
References	Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. - Pubmed Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug;37(8):1611-21. Epub 2009 May 21. - Pubmed
DTHybrid score	0.508

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inducer
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9456
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8131
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7749
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.4192
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5973
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	inducer
References	Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU: Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27. - Pubmed Jemnitz K, Lengyel G, Vereczkey L: In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Biochem Biophys Res Commun. 2002 Feb 15;291(1):29-33. - Pubmed
DTHybrid score	0.3327
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8071
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate,inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4924
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.525
Cytochrome P450 3A43
Name	Cytochrome P450 3A43
Gene Name	CYP3A43
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2356
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7784
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6
Cytochrome P450 4A11
Name	Cytochrome P450 4A11
Gene Name	CYP4A11
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2142

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest. 1999 Jul;104(2):147-53. - Pubmed Fardel O, Lecureur V, Loyer P, Guillouzo A: Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells. Biochem Pharmacol. 1995 May 11;49(9):1255-60. - Pubmed Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed Kuypers DR, Verleden G, Naesens M, Vanrenterghem Y: Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase. Clin Pharmacol Ther. 2005 Jul;78(1):81-8. - Pubmed Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina S: Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2006 Jan;34(1):69-74. Epub 2005 Oct 12. - Pubmed Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. - Pubmed Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E: MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20. - Pubmed Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR: Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem Pharmacol. 2006 Jun 14;71(12):1695-704. Epub 2006 Apr 18. - Pubmed
DTHybrid score	0.9568
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate,inhibitor
References	Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. - Pubmed Cui Y, Konig J, Keppler D: Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol. 2001 Nov;60(5):934-43. - Pubmed
DTHybrid score	0.406
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Courtois A, Payen L, Vernhet L, de Vries EG, Guillouzo A, Fardel O: Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells. Cancer Lett. 1999 May 3;139(1):97-104. - Pubmed
DTHybrid score	0.4292
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	inhibitor
References	Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. - Pubmed
DTHybrid score	0.3749
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. - Pubmed Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. - Pubmed
DTHybrid score	0.3521
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. - Pubmed Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B: Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology. 2000 Jul;32(1):82-6. - Pubmed Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE: Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999 Jul;290(1):153-7. - Pubmed
DTHybrid score	0.4987
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score	0.2947
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. - Pubmed Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. - Pubmed
DTHybrid score	0.5843
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	inducer
References	Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. - Pubmed
DTHybrid score	0.2235
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inducer
References	Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. - Pubmed Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D: The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol. 2000 Nov;157(5):1575-80. - Pubmed
DTHybrid score	0.5571
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inducer
References	Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. - Pubmed
DTHybrid score	0.2992

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.6475
5773	DNA-directed RNA polymerase beta chain	rpoB	0.5243
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.4118
6024	Cytochrome P450 1A1	CYP1A1	0.3312
587	Serum albumin	ALB	0.2978
1729	Solute carrier family 22 member 6	SLC22A6	0.2752
2164	Multidrug resistance-associated protein 4	ABCC4	0.2581
6142	Solute carrier family 22 member 8	SLC22A8	0.2571
512	DNA-directed RNA polymerase alpha chain	rpoA	0.2174
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.2174
20	Prostaglandin G/H synthase 1	PTGS1	0.2081
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1705
6145	Solute carrier family 22 member 1	SLC22A1	0.1639
1898	Cytochrome P450 1B1	CYP1B1	0.1639
6141	Sodium/bile acid cotransporter	SLC10A1	0.1625
6106	Cytochrome P450 2C18	CYP2C18	0.1624
1024	Solute carrier family 22 member 11	SLC22A11	0.1489
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1349
6144	Solute carrier family 22 member 2	SLC22A2	0.132
3811	Cytochrome P450 19A1	CYP19A1	0.1266
290	Prostaglandin G/H synthase 2	PTGS2	0.1216
6148	Multidrug resistance-associated protein 7	ABCC10	0.1169
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1144
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.1141
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1127
2091	Endoplasmin	HSP90B1	0.112
136	Estrogen receptor	ESR1	0.1092
492	Histamine H1 receptor	HRH1	0.1056
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.1032
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.1032
118	Organic cation/carnitine transporter 2	SLC22A5	0.1
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0989
738	Monocarboxylate transporter 1	SLC16A1	0.0956
6137	Multidrug resistance-associated protein 6	ABCC6	0.0906
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0874
6147	Solute carrier family 22 member 3	SLC22A3	0.0837
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.083
824	Sodium-dependent serotonin transporter	SLC6A4	0.0826
817	DNA topoisomerase 2-alpha	TOP2A	0.0804
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0794
731	HIV-1 protease	HIV-1 protease	0.0758
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0748
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0736
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0729
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0724
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0717
70	Type-1 angiotensin II receptor	AGTR1	0.0707
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.069
871	Glucocorticoid receptor	NR3C1	0.0685
556	Alpha-1A adrenergic receptor	ADRA1A	0.066
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0646
833	Organic cation/carnitine transporter 1	SLC22A4	0.0629
3587	Gastrotropin	FABP6	0.0623
831	D(2) dopamine receptor	DRD2	0.0621
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0615
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0614
847	Mu-type opioid receptor	OPRM1	0.0613
260	Cytochrome P450 51	ERG11	0.0599
761	Cytochrome P450 51	ERG11	0.0599
3163	Cytochrome P450 51	cyp51	0.0599
275	Arachidonate 5-lipoxygenase	ALOX5	0.0597
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0593
3941	Amine oxidase [flavin-containing] A	MAOA	0.0585
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0576
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0574
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0571
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0569
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0561
4604	Liver carboxylesterase 1	CES1	0.0545
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0537
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0536
6167	Organic solute transporter subunit beta	OSTB	0.0533
6166	Organic solute transporter subunit alpha	OSTA	0.0533
29	Tubulin beta-1 chain	TUBB1	0.0528
3923	Cholinesterase	BCHE	0.0521
318	Alpha-2A adrenergic receptor	ADRA2A	0.0517
3947	Xanthine dehydrogenase/oxidase	XDH	0.0509
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0505
103	Muscarinic acetylcholine receptor M1	CHRM1	0.05
467	Delta-type opioid receptor	OPRD1	0.0497
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0494
766	Beta-2 adrenergic receptor	ADRB2	0.0488
33	Cystine/glutamate transporter	SLC7A11	0.0488
146	Androgen receptor	AR	0.0477
696	Kappa-type opioid receptor	OPRK1	0.0474
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0472
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0471
51	Muscarinic acetylcholine receptor M3	CHRM3	0.047
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0468
904	Glutathione S-transferase P	GSTP1	0.0466
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0461
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0457
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0456
6085	Fatty acid-binding protein, intestinal	FABP2	0.0454
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0451
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0439
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0436
380	Cytochrome P450 17A1	CYP17A1	0.0434
713	Sodium-dependent dopamine transporter	SLC6A3	0.0431
756	Sex hormone-binding globulin	SHBG	0.043
477	DNA topoisomerase 4 subunit A	parC	0.0426
886	DNA topoisomerase 4 subunit A	parC	0.0426
6226	DNA topoisomerase 4 subunit A	parC	0.0426
273	Apoptosis regulator Bcl-2	BCL2	0.0425
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0425
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0421
404	DNA gyrase subunit A	gyrA	0.042
6224	DNA gyrase subunit A	gyrA	0.042
23	D(1A) dopamine receptor	DRD1	0.0414
465	Calmodulin	CALM1	0.0412
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0408
24	Thymidylate synthase	TMP1	0.0402
359	Thymidylate synthase	TYMS	0.0402
2626	Thymidylate synthase	thyA	0.0402
2729	Thymidylate synthase	thyA	0.0402
5352	Thymidylate synthase	THYA	0.0402
6020	Aldehyde oxidase	AOX1	0.0401
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0401
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0398
632	Alpha-1B adrenergic receptor	ADRA1B	0.0397
869	Estrogen receptor beta	ESR2	0.0397
26	Vascular endothelial growth factor receptor 3	FLT4	0.0396
3939	Amine oxidase [flavin-containing] B	MAOB	0.0393
504	Mast/stem cell growth factor receptor	KIT	0.0391
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0388
844	Epidermal growth factor receptor	EGFR	0.0385
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0385
614	Progesterone receptor	PGR	0.0385
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0381
6220	Aryl hydrocarbon receptor	AHR	0.0379
32	Vascular endothelial growth factor receptor 1	FLT1	0.0378
161	Tubulin beta chain	TUBB	0.0374
312	Tubulin beta chain	TUB2	0.0374
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0371
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.037
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0367
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0366
6149	Solute carrier family 22 member 10	SLC22A10	0.0364
407	Vascular endothelial growth factor receptor 2	KDR	0.0363
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0361
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0358
737	Mineralocorticoid receptor	NR3C2	0.0355
5923	Microtubule-associated protein tau	MAPT	0.0351
5924	Microtubule-associated protein 4	MAP4	0.0351
1852	Microtubule-associated protein 2	MAP2	0.0351
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0351
3932	Glutathione S-transferase A2	GSTA2	0.0348
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0344
84	Nuclear receptor 0B1	NR0B1	0.0342
6014	Cytochrome P450 2A13	CYP2A13	0.0341
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0339
3810	Catechol O-methyltransferase	COMT	0.0338
2539	Tubulin alpha-1 chain	TUBA4A	0.0337
908	Glutathione S-transferase theta-1	GSTT1	0.0335
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0332
88	Retinoic acid receptor RXR-beta	RXRB	0.0328
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0326
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0326
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0326
373	Transthyretin	TTR	0.0325
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0324
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0317
638	D(3) dopamine receptor	DRD3	0.0316
122	P2Y purinoceptor 12	P2RY12	0.0314
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0313
6182	Cytochrome P450 2J2	CYP2J2	0.0312
6102	Arylamine N-acetyltransferase 2	NAT2	0.0312
4120	NADPH--cytochrome P450 reductase	POR	0.0306
1757	Myeloperoxidase	MPO	0.0303
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0298
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0295
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0294
193	Beta-1 adrenergic receptor	ADRB1	0.0293
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0293
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0291
85	Growth hormone receptor	GHR	0.0291
758	Thyroid hormone receptor alpha	THRA	0.0291
811	Translocator protein	TSPO	0.0291
3917	Methylenetetrahydrofolate reductase	MTHFR	0.029
4122	Histone deacetylase 2	HDAC2	0.0288
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0288
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0283
469	Annexin A1	ANXA1	0.0283
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0281
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0281
952	Dipeptidyl peptidase 4	DPP4	0.0279
482	Glycine receptor subunit alpha-1	GLRA1	0.0277
4238	50S ribosomal protein L4	rplD	0.0277
5578	50S ribosomal protein L4	rplD	0.0277
6173	50S ribosomal protein L4	rplD	0.0277
6219	50S ribosomal protein L4	rplD	0.0277
6026	Alcohol dehydrogenase 6	ADH6	0.0275
16	Adenosine A1 receptor	ADORA1	0.0274
4237	50S ribosomal protein L22	rplV	0.0274
594	Thyroxine-binding globulin	SERPINA7	0.0272
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0272
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0271
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.027
789	Alpha-1D adrenergic receptor	ADRA1D	0.0263
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0261
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0261
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0261
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0261
6174	50S ribosomal protein L32	rpmF	0.0261
4773	Deoxycytidine kinase	DCK	0.0261
346	Thyroid hormone receptor beta-1	THRB	0.026
5880	Thrombopoietin receptor	MPL	0.0259
36	Insulin receptor	INSR	0.0258
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0257
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0255
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0255
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0255
1010	Cytochrome P450 51A1	CYP51A1	0.0254
891	Dihydropteroate synthase	folP	0.0252
5359	Dihydropteroate synthase	folP	0.0252
7175	Dihydropteroate synthase	sulI	0.0252
818	50S ribosomal protein L10	rplJ	0.0251
777	Tumor necrosis factor	TNF	0.025
1178	Adenosine A2a receptor	ADORA2A	0.0247
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0247
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0246
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0246
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0246
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0246
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0245
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0245
5626	Nucleoside diphosphate kinase B	NME2	0.0243
2808	Chloramphenicol acetyltransferase 3	cat3	0.0243
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0243
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0242
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
6283	Oxysterols receptor LXR-alpha	NR1H3	0.0242
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0241
3809	Estrogen-related receptor gamma	ESRRG	0.024
517	Alcohol dehydrogenase 1C	ADH1C	0.0234
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0233
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0232
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0232
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0231
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0229
489	Monocarboxylate transporter 2	SLC16A7	0.0227
232	Corticosteroid-binding globulin	SERPINA6	0.0226
629	Alpha-2B adrenergic receptor	ADRA2B	0.0225
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0222
6146	High affinity copper uptake protein 1	SLC31A1	0.022
672	Prostaglandin F2-alpha receptor	PTGFR	0.022
244	Angiotensin-converting enzyme	ACE	0.0219
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0217
1192	Sulfotransferase 1A1	SULT1A1	0.0217
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0214
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0213
705	Glutamate receptor 1	GRIA1	0.0213
4311	tRNA	TRDMT1	0.0213
4325	tRNA	trmD	0.0213
4328	tRNA	trmD	0.0213
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0213
6228	Nuclear receptor coactivator 1	NCOA1	0.021
124	Histamine H2 receptor	HRH2	0.0209
921	Glutamate receptor 2	GRIA2	0.0209
49	Endothelin B receptor	EDNRB	0.0209
378	Alpha-2C adrenergic receptor	ADRA2C	0.0209
6241	Nuclear receptor coactivator 2	NCOA2	0.0208
251	Alcohol dehydrogenase 1A	ADH1A	0.0206
7	Nitric oxide synthase, inducible	NOS2	0.0205
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0204
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
683	Potassium transporter	GK0582	0.0203
4192	DNA topoisomerase 2-beta	TOP2B	0.0202
896	Glutathione S-transferase Mu 1	GSTM1	0.0202
319	Opioid receptor, sigma 1	OPRS1	0.0202
117	Sterol O-acyltransferase 1	SOAT1	0.0202
1650	Heme carrier protein 1	SLC46A1	0.0201
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0199
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0199
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
578	Endothelin-1 receptor	EDNRA	0.0197
94	5-hydroxytryptamine 4 receptor	HTR4	0.0197
365	Dihydrofolate reductase	DHFR	0.0197
2381	Dihydrofolate reductase	DFR1	0.0197
2833	Dihydrofolate reductase	Not Available	0.0197
2931	Dihydrofolate reductase	folA	0.0197
3544	Dihydrofolate reductase	folA	0.0197
3682	Dihydrofolate reductase	folA	0.0197
6642	Dihydrofolate reductase	folA	0.0197
6756	Dihydrofolate reductase	dfrA	0.0197
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0196
6163	Copper-transporting ATPase 2	ATP7B	0.0195
6165	Copper-transporting ATPase 1	ATP7A	0.0195
5294	Nucleoside diphosphate kinase A	NME1	0.0195
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0193
3685	Catabolite gene activator	crp	0.0193
4655	Adenylate cyclase	cyaC	0.0193
4759	Adenylate cyclase	cyaB2	0.0193
444	Alcohol dehydrogenase 1B	ADH1B	0.0193
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0191
4226	Uridine phosphorylase 2	UPP2	0.019
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.019
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.019
293	Gamma-glutamyl hydrolase	GGH	0.0187
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0186
432	D(4) dopamine receptor	DRD4	0.0186
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0186
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0185
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0184
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0183
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0183
716	5-hydroxytryptamine 7 receptor	HTR7	0.0183
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0181
3270	Elongation factor G	fusA	0.0181
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.018
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.018
1483	Membrane copper amine oxidase	AOC3	0.0178
1630	Integrin beta-2	ITGB2	0.0178
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0177
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0177
1760	Aminopeptidase N	ANPEP	0.0176
6843	Aminopeptidase N	pepN	0.0176
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0175
165	FL cytokine receptor	FLT3	0.0175
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0174
3913	Glutamic acid decarboxylase	GAD65	0.0173
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0173
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0173
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0172
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0172
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0172
131	Synaptic vesicular amine transporter	SLC18A2	0.0172
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0171
4225	Uridine phosphorylase 1	UPP1	0.017
427	Substance-P receptor	TACR1	0.017
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.017
3957	Adenosine deaminase	ADA	0.0169
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0168
1353	DNA topoisomerase 1	TOP1	0.0167
3552	DNA topoisomerase 1	topA	0.0167
1629	Transcription factor AP-1	JUN	0.0167
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0167
6218	Pannexin-1	PANX1	0.0166
723	Cytosolic phospholipase A2	PLA2G4A	0.0166
1050	Bile salt sulfotransferase	SULT2A1	0.0165
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0165
4760	Mll3241 protein	mll3241	0.0164
413	Amidophosphoribosyltransferase	PPAT	0.0162
2515	Amidophosphoribosyltransferase	purF	0.0162
3714	Amidophosphoribosyltransferase	purF	0.0162
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0162
13	Aminomethyltransferase, mitochondrial	AMT	0.0162
6044	Serum paraoxonase/lactonase 3	PON3	0.0161
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0161
199	Monocarboxylate transporter 8	SLC16A2	0.0159
4217	Telomerase reverse transcriptase	TERT	0.0159
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0159
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0158
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0158
1656	CYP2B protein	CYP2B	0.0157
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0157
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0157
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0156
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0154
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0153
823	Fibroblast growth factor receptor 2	FGFR2	0.0151
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0151
6151	Monocarboxylate transporter 10	SLC16A10	0.0151
6043	Putative G-protein coupled receptor 44	GPR44	0.015
2981	Phospholipase A2, membrane associated	PLA2G2A	0.015
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0149
183	Vascular endothelial growth factor A	VEGFA	0.0148
527	Prostacyclin receptor	PTGIR	0.0147
3639	Thymidine phosphorylase	deoA	0.0147
3936	Thymidine phosphorylase	TYMP	0.0147
3426	Glutamine synthetase	glnA	0.0146
3987	Glutamine synthetase	GLUL	0.0146
780	Retinoic acid receptor RXR-gamma	RXRG	0.0146
3904	Alanine aminotransferase 2	GPT2	0.0145
3856	Fibroblast growth factor receptor 3	FGFR3	0.0145
735	Alanine aminotransferase 1	GPT	0.0145
563	Thyroid peroxidase	TPO	0.0145
719	Retinoic acid receptor responder protein 1	RARRES1	0.0144
770	Retinoic acid-induced protein 3	GPRC5A	0.0144
2449	Tubulin alpha-3 chain	TUBA1A	0.0143
2391	Ferrochelatase	hemH	0.0143
6502	Ferrochelatase	DKFZp686P18130	0.0143
1591	Ferrochelatase, mitochondrial	FECH	0.0143
6138	Multidrug resistance protein 3	ABCB4	0.0142
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0141
1792	Tissue-type plasminogen activator	PLAT	0.0141
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.014
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0139
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0139
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0138
5787	Angiopoietin-1 receptor	TEK	0.0137
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0136
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0136
174	Sigma 1-type opioid receptor	SIGMAR1	0.0134
1313	Lactoylglutathione lyase	GLO1	0.0134
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0133
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0133
569	Retinal dehydrogenase 2	ALDH1A2	0.0133
185	Vasopressin V1a receptor	AVPR1A	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
295	Carbonic anhydrase 1	CA1	0.013
140	30S ribosomal protein S9	rpsI	0.013
6719	30S ribosomal protein S9	rpsI	0.013
6725	30S ribosomal protein S9	rpsI	0.013
3307	Acriflavine resistance protein B	acrB	0.013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.013
2298	Cytochrome P450-cam	camC	0.0129
5818	Folate receptor alpha	FOLR1	0.0129
768	FK506-binding protein 1A	FKBP1A	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0126
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0126
558	Solute carrier family 12 member 1	SLC12A1	0.0125
899	Glutathione S-transferase Mu 3	GSTM3	0.0125
905	Glutathione transferase omega-1	GSTO1	0.0125
162	Retinoic acid receptor gamma-1	RARG	0.0125
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0124
572	Integrin alpha-L	ITGAL	0.0124
611	Retinal dehydrogenase 1	ALDH1A1	0.0124
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0123
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0123
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0123
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0123
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0123
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0123
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0123
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0123
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0123
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0123
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0123
6559	Cytochrome c oxidase subunit 2	ctaC	0.0123
6669	Cytochrome c oxidase subunit 2	ctaC	0.0123
2021	Thrombomodulin	THBD	0.0123
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0123
6558	Cytochrome c oxidase subunit 1	ctaD	0.0123
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
2320	Thymidine kinase, cytosolic	TK1	0.0121
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0121
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.012
820	Glycine receptor subunit alpha-2	GLRA2	0.012
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0119
1618	High affinity nerve growth factor receptor	NTRK1	0.0119
6042	Prostaglandin reductase 2	PTGR2	0.0119
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0119
267	Plasminogen activator inhibitor 1	SERPINE1	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0117
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0117
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
6210	Tubulin delta chain	TUBD1	0.0114
6212	Tubulin gamma-1 chain	TUBG1	0.0114
6211	Tubulin epsilon chain	TUBE1	0.0114
751	Potassium channel subfamily K member 6	KCNK6	0.0114
2230	Catalase	CAT	0.0114
3249	Catalase	katA	0.0114
3625	Catalase	katA	0.0114
4539	Catalase	katA	0.0114
4941	Catalase	katB	0.0114
2540	Choloylglycine hydrolase	cbh	0.0113
22	30S ribosomal protein S4	rpsD	0.0113
6714	30S ribosomal protein S4	rpsD	0.0113
518	Peroxidase/catalase T	katG	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0111
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0111
500	Monocarboxylate transporter 4	SLC16A3	0.0111
592	Carbonic anhydrase 4	CA4	0.011
6033	High affinity interleukin-8 receptor A	CXCR1	0.011
1517	Beta-3 adrenergic receptor	ADRB3	0.0109
6221	Steroid hormone receptor ERR1	ESRRA	0.0108
2443	Azurin	azu	0.0108
6168	Solute carrier family 22 member 16	SLC22A16	0.0108
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0107
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0107
239	Coagulation factor X	F10	0.0107
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
6501	Fatty acid-binding protein, liver	FABP1	0.0106
887	DNA gyrase subunit B	gyrB	0.0105
4150	DNA gyrase subunit B	gyrB	0.0105
6225	DNA gyrase subunit B	gyrB	0.0105
5934	Cytochrome P450 26A1	CYP26A1	0.0105
6171	Solute carrier family 28 member 3	SLC28A3	0.0105
172	Potassium channel subfamily K member 1	KCNK1	0.0105
1275	Estrogen sulfotransferase	SULT1E1	0.0104
976	Platelet glycoprotein IX	GP9	0.0104
6837	Serine/threonine-protein kinase 17B	STK17B	0.0104
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0104
163	D(1B) dopamine receptor	DRD5	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0101
474	Acetylcholinesterase	ACHE	0.01
461	Glycine receptor subunit alpha-3	GLRA3	0.01
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0098
5650	NimA-related protein	DR_0842	0.0098
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0098
283	SEC14-like protein 2	SEC14L2	0.0098
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0097
68	Cannabinoid receptor 1	CNR1	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
814	Ryanodine receptor 1	RYR1	0.0097
357	Carbonic anhydrase 2	CA2	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
2599	Tyrosine-protein kinase HCK	HCK	0.0096
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
1405	Thiopurine S-methyltransferase	TPMT	0.0095
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0094
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0092
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0092
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0092
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0091
153	Dopamine beta-hydroxylase	DBH	0.0091
6432	Transporter	snf	0.009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.009
3937	Fatty-acid amide hydrolase	FAAH	0.0089
6500	Phospholipase A2	PLA2G1B	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0088
159	Penicillin-binding protein 2B	penA	0.0088
6121	Penicillin-binding protein 2B	penA	0.0088
702	UMP-CMP kinase	CMPK1	0.0088
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0088
714	Glutathione reductase, mitochondrial	GSR	0.0088
992	Protein tyrosine kinase 2 beta	PTK2B	0.0088
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0088
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0088
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0087
86	SEC14-like protein 4	SEC14L4	0.0087
375	SEC14-like protein 3	SEC14L3	0.0087
4076	Diacylglycerol kinase alpha	DGKA	0.0087
5353	Glutamate decarboxylase alpha	gadA	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
54	Prothrombin	F2	0.0087
299	Folate receptor beta	FOLR2	0.0086
718	Folate receptor gamma	FOLR3	0.0086
997	Protein kinase C beta type	PRKCB	0.0086
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0086
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0083
708	Alpha-tocopherol transfer protein	TTPA	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0082
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
338	DNA polymerase	UL30	0.0081
379	DNA polymerase	UL54	0.0081
697	DNA polymerase	ORF28	0.0081
2482	DNA polymerase	43	0.0081
4104	DNA polymerase	BALF5	0.0081
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.008
1196	Complement decay-accelerating factor	CD55	0.008
1525	Heparin-binding growth factor 2	FGF2	0.008
3601	Dihydropteroate synthase 1	folP1	0.0079
3807	Dihydropteroate synthase 1	folP1	0.0079
3808	Dihydropteroate synthase 2	folP2	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
1970	Protein kinase C alpha type	PRKCA	0.0079
291	Nitric-oxide synthase, endothelial	NOS3	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0077
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
4203	Histamine N-methyltransferase	HNMT	0.0077
1867	Major prion protein	PRNP	0.0077
6126	Carbonic anhydrase 7	CA7	0.0076
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0076
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0076
65	Matrix metalloproteinase-9	Not Available	0.0075
1039	Histone deacetylase 9	HDAC9	0.0075
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0074
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0074
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0074
1541	Metalloproteinase	mmp20	0.0074
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
810	Heme oxygenase 1	HMOX1	0.0073
3391	Heme oxygenase 1	pbsA1	0.0073
936	Ephrin type-A receptor 2	EPHA2	0.0073
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0073
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0073
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0073
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0073
106	Cannabinoid receptor 2	CNR2	0.0072
790	DNA polymerase subunit alpha B	POLA2	0.0071
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
663	Solute carrier family 12 member 4	SLC12A4	0.0071
53	Solute carrier family 12 member 5	SLC12A5	0.0071
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.007
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0069
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0068
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0067
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0067
6824	Tyrosine-protein kinase Lyn	LYN	0.0066
6207	30S ribosomal protein S14	rpsN	0.0066
6209	30S ribosomal protein S19	rpsS	0.0066
6712	30S ribosomal protein S19	rpsS	0.0066
6726	30S ribosomal protein S19	rpsS	0.0066
856	Vitamin D3 receptor	VDR	0.0066
310	Solute carrier family 12 member 2	SLC12A2	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0065
2499	Tubulin beta-2C chain	TUBB2C	0.0065
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0065
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0065
5798	Mitogen-activated protein kinase 11	MAPK11	0.0065
2216	Fibroblast growth factor receptor 4	FGFR4	0.0064
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0064
268	Adenosine A2b receptor	ADORA2B	0.0064
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
509	Thymidine kinase	TK	0.0063
570	Thymidine kinase	TK	0.0063
2559	Thymidine kinase	TK	0.0063
3430	Thymidine kinase	tdk	0.0063
3518	Thymidine kinase	TK	0.0063
5301	Thymidine kinase	tdk	0.0063
5771	Thymidine kinase	ORF36	0.0063
7009	Thymidine kinase	ORF36	0.0063
133	Dihydropterate synthase	sulI	0.0063
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4041	Microsomal glutathione S-transferase 2	MGST2	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
760	Fibroblast growth factor 1	FGF1	0.0061
4034	Glutaredoxin-1	GLRX	0.0061
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0061
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0061
1928	Leukotriene C4 synthase	LTC4S	0.0061
4037	Hypothetical protein	GPX1	0.0061
4297	Hypothetical protein	SP_1951	0.0061
4521	Hypothetical protein	BC_2969	0.0061
4540	Hypothetical protein	TM_1070	0.0061
4555	Hypothetical protein	MT1739	0.0061
4569	Hypothetical protein	mshD	0.0061
4578	Hypothetical protein	PA3270	0.0061
4747	Hypothetical protein	PA3967	0.0061
5177	Hypothetical protein	TM_0096	0.0061
5194	Hypothetical protein	PA1204	0.0061
5240	Hypothetical protein	Rv2991	0.0061
5370	Hypothetical protein	TM_1158	0.0061
5710	Hypothetical protein	Tb927.5.1360	0.0061
4029	Microsomal glutathione S-transferase 3	MGST3	0.0061
4032	Microsomal glutathione S-transferase 1	MGST1	0.0061
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0061
4035	Glutathione S-transferase Mu 5	GSTM5	0.0061
4040	Glutathione peroxidase 7	GPX7	0.0061
910	Epididymal secretory glutathione peroxidase	GPX5	0.0061
906	Glutathione peroxidase 1	GPX1	0.0061
4036	Glutathione peroxidase 6	GPX6	0.0061
907	Glutathione peroxidase 2	GPX2	0.0061
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0061
903	Glutathione S-transferase A5	GSTA5	0.0061
900	Glutathione S-transferase A4	GSTA4	0.0061
4038	Glutathione peroxidase 4	GPX4	0.0061
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0061
911	Glutathione peroxidase 3	GPX3	0.0061
4042	Glutathione transferase omega-2	GSTO2	0.0061
4033	S-formylglutathione hydrolase	ESD	0.0061
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.006
4103	Proteasome subunit beta type 2	PSMB2	0.006
4102	Proteasome subunit beta type 5	PSMB5	0.006
4101	Proteasome subunit beta type 1	PSMB1	0.006
634	Squalene monooxygenase	SQLE	0.0059
7196	Squalene monooxygenase	ERG1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0059
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
4210	Toll-like receptor 4	TLR4	0.0059
1123	Eosinophil cationic protein	RNASE3	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
76	Nitric-oxide synthase, brain	NOS1	0.0058
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0058
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0056
4692	A/G-specific adenine glycosylase	mutY	0.0055
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0055
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0055
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0055
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0055
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0055
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0055
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0055
897	Glutathione S-transferase kappa 1	GSTK1	0.0055
898	Glutathione S-transferase A3	GSTA3	0.0055
2249	Aspartate aminotransferase	aspC	0.0054
2671	Aspartate aminotransferase	aspC	0.0054
5490	Aspartate aminotransferase	Not Available	0.0054
909	Maleylacetoacetate isomerase	GSTZ1	0.0054
3086	Plasmepsin-2	Not Available	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.005
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0049
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0049
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0049
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0049
484	Tyrosine-protein kinase ABL2	ABL2	0.0048
4031	Glutathione S-transferase A1	GSTA1	0.0048
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0048
2165	Glutathione S-transferase Mu 2	GSTM2	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
207	Glutathione synthetase	GSS	0.0047
5269	Glutathione synthetase	gshB	0.0047
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0047
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0047
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0047
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
128	Adenine phosphoribosyltransferase	APRT	0.0046
1253	Interferon gamma	IFNG	0.0046
3014	Ribonuclease UK114	HRSP12	0.0046
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0046
5428	Replication protein	repA	0.0046
3617	Non-heme chloroperoxidase	cpo	0.0046
5426	Non-heme chloroperoxidase	cpo	0.0046
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0046
3018	HTH-type transcriptional regulator malT	malT	0.0046
173	Toll-like receptor 7	TLR7	0.0046
867	Penicillin-binding protein 3	pbpC	0.0046
6119	Penicillin-binding protein 3	pbp3	0.0046
7154	Penicillin-binding protein 3	pbp3	0.0046
7157	Penicillin-binding protein 3	LMHCC_2184	0.0046
7162	Penicillin-binding protein 3	pbpB	0.0046
7172	Penicillin-binding protein 3	pbp3	0.0046
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0045
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0045
1992	Vitamin D-binding protein	GC	0.0045
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0045
1654	Interleukin-1 beta	IL1B	0.0045
901	Glutathione S-transferase Mu 4	GSTM4	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
1714	Mitogen-activated protein kinase 3	MAPK3	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0044
164	Histamine H4 receptor	HRH4	0.0044
1507	Cytochrome c	CYCS	0.0042
1864	RET proto-oncogene	RET	0.0042
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0042
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0042
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
1569	G1/S-specific cyclin-D1	CCND1	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
400	Coagulation factor IX	F9	0.004
5461	Coagulation factor IX	F9	0.004
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
730	Retinoic acid receptor alpha	RARA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
1268	Neuropeptide S receptor	NPSR1	0.004
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.004
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.004
2958	Probable tautomerase ydcE	pptA	0.004
2207	Rhodopsin	RHO	0.004
2573	Cocaine esterase	cocE	0.004
7263	Cocaine esterase	Not Available	0.004
473	L-lactate dehydrogenase A chain	LDHA	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
3115	Ras-related protein Rab-9	RAB9A	0.0039
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1374	Natriuretic peptides B	NPPB	0.0038
1827	Gap junction alpha-1 protein	GJA1	0.0038
1908	Vascular cell adhesion protein 1	VCAM1	0.0038
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0037
604	Vitamin K-dependent protein Z	PROZ	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
494	Caspase-1	CASP1	0.0036
6073	Potassium channel subfamily K member 9	KCNK9	0.0036
6072	Potassium channel subfamily K member 3	KCNK3	0.0036
1636	Trace amine-associated receptor 1	TAAR1	0.0036
3404	Exotoxin A	eta	0.0036
340	Apoptotic protease-activating factor 1	APAF1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
1245	Vitamin K-dependent protein S	PROS1	0.0034
422	Vitamin K-dependent protein C	PROC	0.0034
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0034
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
3760	Penicillin-binding protein 5 precursor	dacA	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
645	Penicillin-binding protein 1A	mrcA	0.0032
5805	Penicillin-binding protein 1A	ponA	0.0032
6185	Penicillin-binding protein 1A	mrcA	0.0032
6799	Penicillin-binding protein 1A	pbpA	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
411	Glycine N-methyltransferase	GNMT	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2693	Heat-labile enterotoxin B chain	eltB	0.003
2077	Caspase-3	CASP3	0.003
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
6645	D-amino-acid oxidase	DAO	0.0029
819	Penicillin-binding protein 4	dacB	0.0029
292	Activin receptor type-1	ACVR1	0.0029
6459	Glycodelin	PAEP	0.0028
2290	ADP-ribosyl cyclase 2	BST1	0.0028
849	Activated CDC42 kinase 1	TNK2	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
798	Osteocalcin	BGLAP	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
115	Penicillin-binding protein 2	mrdA	0.0027
6069	Penicillin-binding protein 2	mrdA	0.0027
6118	Penicillin-binding protein 2	penA	0.0027
6187	Penicillin-binding protein 2	pbpA	0.0027
6686	Penicillin-binding protein 2	pbp2	0.0027
6939	Penicillin-binding protein 2	mrdA	0.0027
7163	Penicillin-binding protein 2	pbpA	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0026
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
543	Penicillin-binding protein 1B	mrcB	0.0026
6186	Penicillin-binding protein 1B	ponB	0.0026
6822	Penicillin-binding protein 1b	pbp1b	0.0026
6844	Penicillin-binding protein 1b	pbp1b	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
1	Peptidoglycan synthetase ftsI	ftsI	0.0025
4155	Peptidoglycan synthetase ftsI	ftsI	0.0025
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
551	Carnitine O-acetyltransferase	CRAT	0.0025
6859	Protein S100-A4	S100A4	0.0025
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3830	Calreticulin	CALR	0.0025
369	Coagulation factor VII	F7	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
3221	Cytochrome c4	cc4	0.0023
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
332	Beta-lactamase	blaZ	0.0021
2478	Beta-lactamase	ampC	0.0021
2613	Beta-lactamase	ampC	0.0021
2635	Beta-lactamase	ampC	0.0021
2700	Beta-lactamase	penP	0.0021
5445	Beta-lactamase	blaB	0.0021
6019	Beta-lactamase	SHV-7	0.0021
6701	Beta-lactamase	cphA	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
822	Aldose reductase	AKR1B1	0.0019
857	Malate dehydrogenase, mitochondrial	MDH2	0.0019
4992	Cytochrome c peroxidase	Not Available	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
816	Biliverdin reductase A	BLVRA	0.0011
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0011
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0011
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
2802	Endoglucanase G	celCCG	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0011
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0011
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0011
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0011
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0011
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0011
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0011
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0011
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0011
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0011
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0011
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0011
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0011
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0011
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0011
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0011
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0011
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0011
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0011
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0011
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0011
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0011
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0011
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0011
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0011
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0011
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0011
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.001
646	Malate dehydrogenase, cytoplasmic	MDH1	0.001
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.001
3583	6-phosphogluconolactonase	pgl	0.001
328	Sorbitol dehydrogenase	SORD	0.001
396	Alcohol dehydrogenase 4	ADH4	0.001
597	Dihydropteridine reductase	QDPR	0.001
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.001
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
627	11-cis retinol dehydrogenase	RDH5	0.0009
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0009
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
666	NADP-dependent malic enzyme	ME1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0009
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0009
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
626	Cysteine dioxygenase type 1	CDO1	0.0009
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0009
12	Alcohol dehydrogenase class 3	ADH5	0.0009
77	L-lactate dehydrogenase B chain	LDHB	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
2132	Protein S100-B	S100B	0.0009
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0008
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0008
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0008
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0008
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
279	Tyrosinase	TYR	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0008
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
654	Flavin reductase	BLVRB	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
5682	Ribonuclease pancreatic	RNASE1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01045 - Rifampin

Targets

Enzymes

Transporters

Predictions