DT-Web

DB08884 - Gadoxetate


Identification
Name Gadoxetate
Accession Number DB08884
Type small molecule
Description Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. It is marketed by Bayer HealthCare Pharmaceuticals and FDA approved on July 3, 2008.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 725.71
Groups approved
Monoisotopic Weight 726.076023636
Pharmacology
Indication Gadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver.
Mechanism of action When gadoxetate disodium is placed in an external magnetic field, a large magnetic moment is produced. As a result, a magnetic field is induced around the tissue. The water protons in the vicinity are disrupted such that the change the proton density and spin characteristics are detected and visualized by a device.
Absorption Not Available
Protein binding <10% protein bound. Because it is more protein bound than other gadolinium-based contrast agents, gadoxetate disodium has increased T1 relaxivity. This results in an enhancement of the signal.
Biotransformation Gadoxetate disodium is not metabolized.
Route of elimination Gadoxetate disodium is eliminated equally via urine and feces. Multidrug resistance protein 2 actively transports/excretes gadoxetate disodium into the bile.
Toxicity LD50, oral, rat = 18100 mg/kg; LD50, oral, mouse = 14500 mg/kg; LD50, IV, rat = 3600 - 7300 mg/kg; LD50, IV, mouse = 5400 - 10900 mg/kg; LD50, IV, dog = >2200 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Rifampin Substrates of OATP1B1 and OATP1B3 may limit uptake of gadoxetate disodium into heptatocytes. This may alter the intensity of the signal.
Food Interactions Not Available

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kuhn JP: Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Radiology. 2012 Sep;264(3):741-50. doi: 10.1148/radiol.12112061. Epub 2012 Jul 6. - Pubmed
DTHybrid score 0.3188
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kuhn JP: Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Radiology. 2012 Sep;264(3):741-50. doi: 10.1148/radiol.12112061. Epub 2012 Jul 6. - Pubmed
DTHybrid score 0.243
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions substrate
References
  • Van Beers BE, Pastor CM, Hussain HK: Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9. doi: 10.1016/j.jhep.2012.01.031. Epub 2012 Apr 12. - Pubmed
DTHybrid score 0.1714
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • Van Beers BE, Pastor CM, Hussain HK: Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9. doi: 10.1016/j.jhep.2012.01.031. Epub 2012 Apr 12. - Pubmed
DTHybrid score 0.2833
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Van Beers BE, Pastor CM, Hussain HK: Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9. doi: 10.1016/j.jhep.2012.01.031. Epub 2012 Apr 12. - Pubmed
DTHybrid score 0.2149

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1538
4512 Cytochrome P450 3A4 CYP3A4 0.1221
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1208
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1195
4924 Cytochrome P450 2C8 CYP2C8 0.1052
4757 Cytochrome P450 2C9 CYP2C9 0.0997
862 Multidrug resistance-associated protein 1 ABCC1 0.0949
1729 Solute carrier family 22 member 6 SLC22A6 0.0824
6142 Solute carrier family 22 member 8 SLC22A8 0.0809
4118 Cytochrome P450 3A5 CYP3A5 0.073
587 Serum albumin ALB 0.0686
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0681
6016 Cytochrome P450 2C19 CYP2C19 0.0663
776 Bile salt export pump ABCB11 0.066
4200 Cytochrome P450 1A2 CYP1A2 0.0588
6136 Multidrug resistance-associated protein 5 ABCC5 0.0584
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0584
6107 Cytochrome P450 3A7 CYP3A7 0.0537
6141 Sodium/bile acid cotransporter SLC10A1 0.0532
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0519
6148 Multidrug resistance-associated protein 7 ABCC10 0.0492
4119 Cytochrome P450 2D6 CYP2D6 0.0482
70 Type-1 angiotensin II receptor AGTR1 0.0482
6030 Cytochrome P450 2B6 CYP2B6 0.0477
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0438
3587 Gastrotropin FABP6 0.0429
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0428
6143 Solute carrier family 22 member 7 SLC22A7 0.0427
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0412
1024 Solute carrier family 22 member 11 SLC22A11 0.0384
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0379
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0379
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0379
6145 Solute carrier family 22 member 1 SLC22A1 0.0377
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0353
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0343
24 Thymidylate synthase TMP1 0.0338
359 Thymidylate synthase TYMS 0.0338
2626 Thymidylate synthase thyA 0.0338
2729 Thymidylate synthase thyA 0.0338
5352 Thymidylate synthase THYA 0.0338
20 Prostaglandin G/H synthase 1 PTGS1 0.033
6013 Cytochrome P450 2E1 CYP2E1 0.0322
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0319
6137 Multidrug resistance-associated protein 6 ABCC6 0.0287
6024 Cytochrome P450 1A1 CYP1A1 0.0279
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0266
6167 Organic solute transporter subunit beta OSTB 0.0262
6166 Organic solute transporter subunit alpha OSTA 0.0262
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0254
290 Prostaglandin G/H synthase 2 PTGS2 0.0248
6144 Solute carrier family 22 member 2 SLC22A2 0.0246
738 Monocarboxylate transporter 1 SLC16A1 0.0246
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
5626 Nucleoside diphosphate kinase B NME2 0.0223
4604 Liver carboxylesterase 1 CES1 0.0223
5718 Cytochrome P450 2A6 CYP2A6 0.022
118 Organic cation/carnitine transporter 2 SLC22A5 0.0218
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0215
1898 Cytochrome P450 1B1 CYP1B1 0.0207
758 Thyroid hormone receptor alpha THRA 0.0201
3917 Methylenetetrahydrofolate reductase MTHFR 0.0193
1650 Heme carrier protein 1 SLC46A1 0.0187
6147 Solute carrier family 22 member 3 SLC22A3 0.0185
293 Gamma-glutamyl hydrolase GGH 0.0185
346 Thyroid hormone receptor beta-1 THRB 0.018
5294 Nucleoside diphosphate kinase A NME1 0.0179
29 Tubulin beta-1 chain TUBB1 0.0177
33 Cystine/glutamate transporter SLC7A11 0.0175
594 Thyroxine-binding globulin SERPINA7 0.0174
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0167
2539 Tubulin alpha-1 chain TUBA4A 0.0163
136 Estrogen receptor ESR1 0.0161
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0158
13 Aminomethyltransferase, mitochondrial AMT 0.0154
817 DNA topoisomerase 2-alpha TOP2A 0.0147
6085 Fatty acid-binding protein, intestinal FABP2 0.0146
6149 Solute carrier family 22 member 10 SLC22A10 0.0143
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0143
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0138
26 Vascular endothelial growth factor receptor 3 FLT4 0.0136
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0134
908 Glutathione S-transferase theta-1 GSTT1 0.0133
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0131
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0131
468 Cytochrome P450 4A11 CYP4A11 0.013
32 Vascular endothelial growth factor receptor 1 FLT1 0.013
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0129
833 Organic cation/carnitine transporter 1 SLC22A4 0.0125
3947 Xanthine dehydrogenase/oxidase XDH 0.0124
275 Arachidonate 5-lipoxygenase ALOX5 0.0124
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0124
373 Transthyretin TTR 0.0121
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0117
299 Folate receptor beta FOLR2 0.0117
718 Folate receptor gamma FOLR3 0.0117
804 Mitochondrial folate transporter/carrier SLC25A32 0.0116
1760 Aminopeptidase N ANPEP 0.0115
6843 Aminopeptidase N pepN 0.0115
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0113
117 Sterol O-acyltransferase 1 SOAT1 0.0112
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
273 Apoptosis regulator Bcl-2 BCL2 0.011
731 HIV-1 protease HIV-1 protease 0.0109
2443 Azurin azu 0.0108
5923 Microtubule-associated protein tau MAPT 0.0107
5924 Microtubule-associated protein 4 MAP4 0.0107
904 Glutathione S-transferase P GSTP1 0.0105
407 Vascular endothelial growth factor receptor 2 KDR 0.0104
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.01
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.01
6106 Cytochrome P450 2C18 CYP2C18 0.0099
1852 Microtubule-associated protein 2 MAP2 0.0099
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0098
3811 Cytochrome P450 19A1 CYP19A1 0.0098
199 Monocarboxylate transporter 8 SLC16A2 0.0098
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0097
5818 Folate receptor alpha FOLR1 0.0096
6020 Aldehyde oxidase AOX1 0.0094
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
228 Beta platelet-derived growth factor receptor PDGFRB 0.0091
2391 Ferrochelatase hemH 0.009
6502 Ferrochelatase DKFZp686P18130 0.009
1591 Ferrochelatase, mitochondrial FECH 0.009
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0089
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0088
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0086
504 Mast/stem cell growth factor receptor KIT 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
850 Vasopressin V1b receptor AVPR1B 0.0081
896 Glutathione S-transferase Mu 1 GSTM1 0.0081
5880 Thrombopoietin receptor MPL 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
165 FL cytokine receptor FLT3 0.008
702 UMP-CMP kinase CMPK1 0.0079
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0079
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0078
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0078
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0078
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0078
6493 Cytochrome c oxidase subunit 6C COX6C 0.0078
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0078
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0078
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0078
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0078
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0078
6559 Cytochrome c oxidase subunit 2 ctaC 0.0078
6669 Cytochrome c oxidase subunit 2 ctaC 0.0078
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0078
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0078
6558 Cytochrome c oxidase subunit 1 ctaD 0.0078
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0078
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
161 Tubulin beta chain TUBB 0.0075
312 Tubulin beta chain TUB2 0.0075
4226 Uridine phosphorylase 2 UPP2 0.0075
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0075
3809 Estrogen-related receptor gamma ESRRG 0.0073
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0073
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0073
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0073
1648 Elastin ELN 0.0072
2540 Choloylglycine hydrolase cbh 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
6165 Copper-transporting ATPase 1 ATP7A 0.0071
6163 Copper-transporting ATPase 2 ATP7B 0.0071
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0071
6151 Monocarboxylate transporter 10 SLC16A10 0.0071
492 Histamine H1 receptor HRH1 0.007
322 Vasopressin V2 receptor AVPR2 0.007
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0069
1757 Myeloperoxidase MPO 0.0069
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0069
1313 Lactoylglutathione lyase GLO1 0.0069
6220 Aryl hydrocarbon receptor AHR 0.0068
6146 High affinity copper uptake protein 1 SLC31A1 0.0068
4225 Uridine phosphorylase 1 UPP1 0.0068
2298 Cytochrome P450-cam camC 0.0068
6501 Fatty acid-binding protein, liver FABP1 0.0067
3810 Catechol O-methyltransferase COMT 0.0067
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0067
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0067
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0067
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0066
4773 Deoxycytidine kinase DCK 0.0066
284 DNA-directed RNA polymerase beta chain rpoB 0.0066
5773 DNA-directed RNA polymerase beta chain rpoB 0.0066
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0065
413 Amidophosphoribosyltransferase PPAT 0.0064
2515 Amidophosphoribosyltransferase purF 0.0064
3714 Amidophosphoribosyltransferase purF 0.0064
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0064
614 Progesterone receptor PGR 0.0064
6218 Pannexin-1 PANX1 0.0063
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0063
5482 Sialidase-2 NEU2 0.0062
3270 Elongation factor G fusA 0.0062
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0062
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0062
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
6168 Solute carrier family 22 member 16 SLC22A16 0.0061
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
6031 Cytochrome P450 3A43 CYP3A43 0.006
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
4192 DNA topoisomerase 2-beta TOP2B 0.0058
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0057
6500 Phospholipase A2 PLA2G1B 0.0056
6042 Prostaglandin reductase 2 PTGR2 0.0056
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0055
2981 Phospholipase A2, membrane associated PLA2G2A 0.0053
3639 Thymidine phosphorylase deoA 0.0053
3936 Thymidine phosphorylase TYMP 0.0053
4760 Mll3241 protein mll3241 0.0052
489 Monocarboxylate transporter 2 SLC16A7 0.0052
365 Dihydrofolate reductase DHFR 0.0052
2381 Dihydrofolate reductase DFR1 0.0052
2833 Dihydrofolate reductase Not Available 0.0052
2931 Dihydrofolate reductase folA 0.0052
3544 Dihydrofolate reductase folA 0.0052
3682 Dihydrofolate reductase folA 0.0052
6642 Dihydrofolate reductase folA 0.0052
6756 Dihydrofolate reductase dfrA 0.0052
6043 Putative G-protein coupled receptor 44 GPR44 0.0052
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0051
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0051
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.005
517 Alcohol dehydrogenase 1C ADH1C 0.005
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0049
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0048
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0047
3957 Adenosine deaminase ADA 0.0047
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0046
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0046
952 Dipeptidyl peptidase 4 DPP4 0.0045
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
1630 Integrin beta-2 ITGB2 0.0044
6171 Solute carrier family 28 member 3 SLC28A3 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0042
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
3923 Cholinesterase BCHE 0.0041
1629 Transcription factor AP-1 JUN 0.0041
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.004
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
563 Thyroid peroxidase TPO 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0038
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0038
2232 Interleukin-5 IL5 0.0037
260 Cytochrome P450 51 ERG11 0.0037
761 Cytochrome P450 51 ERG11 0.0037
3163 Cytochrome P450 51 cyp51 0.0037
1593 Mucin-2 MUC2 0.0037
4034 Glutaredoxin-1 GLRX 0.0037
1928 Leukotriene C4 synthase LTC4S 0.0037
4037 Hypothetical protein GPX1 0.0037
4297 Hypothetical protein SP_1951 0.0037
4521 Hypothetical protein BC_2969 0.0037
4540 Hypothetical protein TM_1070 0.0037
4555 Hypothetical protein MT1739 0.0037
4569 Hypothetical protein mshD 0.0037
4578 Hypothetical protein PA3270 0.0037
4747 Hypothetical protein PA3967 0.0037
5177 Hypothetical protein TM_0096 0.0037
5194 Hypothetical protein PA1204 0.0037
5240 Hypothetical protein Rv2991 0.0037
5370 Hypothetical protein TM_1158 0.0037
5710 Hypothetical protein Tb927.5.1360 0.0037
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0037
4029 Microsomal glutathione S-transferase 3 MGST3 0.0037
907 Glutathione peroxidase 2 GPX2 0.0037
4032 Microsomal glutathione S-transferase 1 MGST1 0.0037
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0037
910 Epididymal secretory glutathione peroxidase GPX5 0.0037
903 Glutathione S-transferase A5 GSTA5 0.0037
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0037
4036 Glutathione peroxidase 6 GPX6 0.0037
4040 Glutathione peroxidase 7 GPX7 0.0037
911 Glutathione peroxidase 3 GPX3 0.0037
906 Glutathione peroxidase 1 GPX1 0.0037
4035 Glutathione S-transferase Mu 5 GSTM5 0.0037
900 Glutathione S-transferase A4 GSTA4 0.0037
4033 S-formylglutathione hydrolase ESD 0.0037
4038 Glutathione peroxidase 4 GPX4 0.0037
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0037
4042 Glutathione transferase omega-2 GSTO2 0.0037
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0037
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0036
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0034
3319 Hydroxyacylglutathione hydrolase HAGH 0.0033
572 Integrin alpha-L ITGAL 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
898 Glutathione S-transferase A3 GSTA3 0.0033
897 Glutathione S-transferase kappa 1 GSTK1 0.0033
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0033
909 Maleylacetoacetate isomerase GSTZ1 0.0033
4217 Telomerase reverse transcriptase TERT 0.0032
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0032
905 Glutathione transferase omega-1 GSTO1 0.0032
899 Glutathione S-transferase Mu 3 GSTM3 0.0032
1353 DNA topoisomerase 1 TOP1 0.0032
3552 DNA topoisomerase 1 topA 0.0032
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0032
4041 Microsomal glutathione S-transferase 2 MGST2 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
4122 Histone deacetylase 2 HDAC2 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
737 Mineralocorticoid receptor NR3C2 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
2165 Glutathione S-transferase Mu 2 GSTM2 0.0029
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0029
869 Estrogen receptor beta ESR2 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
207 Glutathione synthetase GSS 0.0029
5269 Glutathione synthetase gshB 0.0029
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0029
777 Tumor necrosis factor TNF 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
7 Nitric oxide synthase, inducible NOS2 0.0028
645 Penicillin-binding protein 1A mrcA 0.0028
5805 Penicillin-binding protein 1A ponA 0.0028
6185 Penicillin-binding protein 1A mrcA 0.0028
6799 Penicillin-binding protein 1A pbpA 0.0028
465 Calmodulin CALM1 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
901 Glutathione S-transferase Mu 4 GSTM4 0.0027
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
2021 Thrombomodulin THBD 0.0026
824 Sodium-dependent serotonin transporter SLC6A4 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
172 Potassium channel subfamily K member 1 KCNK1 0.0025
3932 Glutathione S-transferase A2 GSTA2 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
2320 Thymidine kinase, cytosolic TK1 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
4031 Glutathione S-transferase A1 GSTA1 0.0025
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
756 Sex hormone-binding globulin SHBG 0.0024
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
146 Androgen receptor AR 0.0024
714 Glutathione reductase, mitochondrial GSR 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
76 Nitric-oxide synthase, brain NOS1 0.0023
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0018
921 Glutamate receptor 2 GRIA2 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
2449 Tubulin alpha-3 chain TUBA1A 0.0017
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0017
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
357 Carbonic anhydrase 2 CA2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
469 Annexin A1 ANXA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
871 Glucocorticoid receptor NR3C1 0.0006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0006
↑