DT-Web: DB06335

Identification

Name

Saxagliptin

Accession Number

DB06335

Type

small molecule

Description

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

315.41

Groups

approved

Monoisotopic Weight

315.194677059

Pharmacology

Indication

Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.

Mechanism of action

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Absorption

Following a 5 mg single oral dose of saxagliptin to healthy subjects, the mean plasma AUC values for saxagliptin and its active metabolite were 78 ngoh/mL and 214 ngoh/mL, respectively. The corresponding plasma Cmax values were 24 ng/mL and 47 ng/mL, respectively. Saxagliptin did not accumulate following repeated doses. The median time to maximum concentration (Tmax) following the 5 mg once daily dose was 2 hours for saxagliptin and 4 hours for its active metabolite. Bioavailability, 2.5 - 50 mg dose = 67%

Protein binding

The in vitro protein binding of saxagliptin and its active metabolite in human serum is negligible (<10%).

Biotransformation

The metabolism of saxagliptin is primarily mediated by cytochrome P450 3A4/5 (CYP3A4/5). 50% of the absorbed dose will undergo hepatic metabolism. The major metabolite of saxagliptin, 5-hydroxy saxagliptin, is also a DPP4 inhibitor, which is one-half as potent as saxagliptin.

Route of elimination

Saxagliptin is eliminated by both renal and hepatic pathways. Following a single 50 mg dose of 14C-saxagliptin, 24%, 36%, and 75% of the dose was excreted in the urine as saxagliptin, its active metabolite, and total radioactivity, respectively. A total of 22% of the administered radioactivity was recovered in feces representing the fraction of the saxagliptin dose excreted in bile and/or unabsorbed drug from the gastrointestinal tract.

Toxicity

Adverse reactions reported in >=5% of patients treated with saxagliptin and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache.

Affected organisms

Not Available

Interactions

Drug Interactions

Drug	Mechanism of interaction
Clarithromycin	Clarithromycin is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Conivaptan	CYP3A4 Inhibitors (Strong) may increase the serum concentration of Saxagliptin. Limit saxagliptin dose to 2.5 mg/day and monitor for increased saxagliptin levels/effects (e.g., hypoglycemia) with concomitant administration of a strong CYP3A4 inhibitor (e.g., ketoconazole). Monitor for decreased saxagliptin levels/effects with discontinuation of concomitant CYP3A4 inhibitor.
Diltiazem	Diltiazem is a moderate inhibitor of CYP3A4 and increases AUC of saxagliptin by 109%. Exposure of the active metabolite decreased by 34%. However, these changes in pharmacokinetics are not clinical significant.
Erythromycin	Erythromycin is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Indinavir	Indinavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Ketoconazole	Ketoconazole is a strong inhibitor of CYP3A4/5 which increases exposure of saxagliptin. The exposure of the active metabolite, 5-hydroxy saxagliptin, also decreases. Decrease dose of saxagliptin to 2.5 mg per day.
Nefazodone	Nefazodone is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Nelfinavir	Nelfinavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Rifampin	Rifampin is a strong inducer of CYP3A4 which decreases exposure of saxagliptin. The exposure of the active metabolite, 5-hydroxy saxagliptin, also increases.
Ritonavir	Ritonavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Simvastatin	Simvastatin is a moderate inhibitor of CYP3A4 and increases AUC of saxagliptin by 12%. Exposure of the active metabolite decreased by 2%. However, these changes in pharmacokinetics are not clinical significant.
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of saxagliptin. Monitor for changes in fasting and postprandial blood sugars.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of saxagliptin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of saxagliptin if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Administration with a high-fat meal resulted in an increase in Tmax of saxagliptin by approximately 20 minutes as compared to fasted conditions. There was a 27% increase in the AUC of saxagliptin when given with a meal as compared to fasted conditions.

Dipeptidyl peptidase 4
Name	Dipeptidyl peptidase 4
Gene Name	DPP4
Pharmacological action	yes
Actions	inhibitor
References	Augeri DJ, Robl JA, Betebenner DA, Magnin DR, Khanna A, Robertson JG, Wang A, Simpkins LM, Taunk P, Huang Q, Han SP, Abboa-Offei B, Cap M, Xin L, Tao L, Tozzo E, Welzel GE, Egan DM, Marcinkeviciene J, Chang SY, Biller SA, Kirby MS, Parker RA, Hamann LG: Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jul 28;48(15):5025-37. - Pubmed
DTHybrid score	1.7194

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	- Upreti VV, Boulton DW, Li L, Ching A, Su H, Lacreta FP, Patel CG: Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects. Br J Clin Pharmacol. 2011 Jul;72(1):92-102. doi: 10.1111/j.1365-2125.2011.03937.x. - Pubmed Patel CG, Kornhauser D, Vachharajani N, Komoroski B, Brenner E, Handschuh Del Corral M, Li L, Boulton DW: Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects. Diabetes Obes Metab. 2011 Jul;13(7):604-14. doi: 10.1111/j.1463-1326.2011.01381.x. - Pubmed Scheen AJ: Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet. 2010 Sep 1;49(9):573-88. doi: 10.2165/11532980-000000000-00000. - Pubmed
DTHybrid score	0.4279
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Upreti VV, Boulton DW, Li L, Ching A, Su H, Lacreta FP, Patel CG: Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects. Br J Clin Pharmacol. 2011 Jul;72(1):92-102. doi: 10.1111/j.1365-2125.2011.03937.x. - Pubmed Patel CG, Kornhauser D, Vachharajani N, Komoroski B, Brenner E, Handschuh Del Corral M, Li L, Boulton DW: Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects. Diabetes Obes Metab. 2011 Jul;13(7):604-14. doi: 10.1111/j.1463-1326.2011.01381.x. - Pubmed Scheen AJ: Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet. 2010 Sep 1;49(9):573-88. doi: 10.2165/11532980-000000000-00000. - Pubmed
DTHybrid score	0.2401

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate
References	Scheen AJ: Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet. 2010 Sep;49(9):573-88. doi: 10.2165/11532980-000000000-00000. - Pubmed
DTHybrid score	0.1922
Solute carrier organic anion transporter family member 4C1
Name	Solute carrier organic anion transporter family member 4C1
Gene Name	SLCO4C1
Actions	substrate
References	Golightly LK, Drayna CC, McDermott MT: Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. doi: 10.2165/11632930-000000000-00000. - Pubmed
DTHybrid score	0.1672
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	Golightly LK, Drayna CC, McDermott MT: Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. doi: 10.2165/11632930-000000000-00000. - Pubmed
DTHybrid score	0.2269

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.1936
6107	Cytochrome P450 3A7	CYP3A7	0.1324
4119	Cytochrome P450 2D6	CYP2D6	0.1255
4757	Cytochrome P450 2C9	CYP2C9	0.1164
4924	Cytochrome P450 2C8	CYP2C8	0.1062
6016	Cytochrome P450 2C19	CYP2C19	0.1026
1729	Solute carrier family 22 member 6	SLC22A6	0.1012
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0944
4200	Cytochrome P450 1A2	CYP1A2	0.0917
587	Serum albumin	ALB	0.0862
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0802
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.075
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0718
1024	Solute carrier family 22 member 11	SLC22A11	0.0709
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0662
6030	Cytochrome P450 2B6	CYP2B6	0.0637
6143	Solute carrier family 22 member 7	SLC22A7	0.0622
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0611
6024	Cytochrome P450 1A1	CYP1A1	0.0544
758	Thyroid hormone receptor alpha	THRA	0.052
6013	Cytochrome P450 2E1	CYP2E1	0.0481
776	Bile salt export pump	ABCB11	0.0462
346	Thyroid hormone receptor beta-1	THRB	0.0433
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0429
2164	Multidrug resistance-associated protein 4	ABCC4	0.0428
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.042
118	Organic cation/carnitine transporter 2	SLC22A5	0.0364
6145	Solute carrier family 22 member 1	SLC22A1	0.0363
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0358
594	Thyroxine-binding globulin	SERPINA7	0.0357
6144	Solute carrier family 22 member 2	SLC22A2	0.034
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0333
6141	Sodium/bile acid cotransporter	SLC10A1	0.032
20	Prostaglandin G/H synthase 1	PTGS1	0.032
817	DNA topoisomerase 2-alpha	TOP2A	0.0313
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0306
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0285
6148	Multidrug resistance-associated protein 7	ABCC10	0.0282
5718	Cytochrome P450 2A6	CYP2A6	0.0275
731	HIV-1 protease	HIV-1 protease	0.0265
1898	Cytochrome P450 1B1	CYP1B1	0.0254
871	Glucocorticoid receptor	NR3C1	0.025
290	Prostaglandin G/H synthase 2	PTGS2	0.025
373	Transthyretin	TTR	0.0247
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0239
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0232
6137	Multidrug resistance-associated protein 6	ABCC6	0.0228
3811	Cytochrome P450 19A1	CYP19A1	0.0222
6147	Solute carrier family 22 member 3	SLC22A3	0.0217
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0201
833	Organic cation/carnitine transporter 1	SLC22A4	0.0198
957	Glucagon-like peptide 1 receptor	GLP1R	0.0193
6136	Multidrug resistance-associated protein 5	ABCC5	0.0192
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0189
738	Monocarboxylate transporter 1	SLC16A1	0.0188
492	Histamine H1 receptor	HRH1	0.0186
199	Monocarboxylate transporter 8	SLC16A2	0.0185
563	Thyroid peroxidase	TPO	0.0183
6167	Organic solute transporter subunit beta	OSTB	0.0181
6106	Cytochrome P450 2C18	CYP2C18	0.0181
6166	Organic solute transporter subunit alpha	OSTA	0.0181
6020	Aldehyde oxidase	AOX1	0.0178
5660	Esterase EstB	estB	0.0178
136	Estrogen receptor	ESR1	0.0174
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0174
6031	Cytochrome P450 3A43	CYP3A43	0.0168
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0164
847	Mu-type opioid receptor	OPRM1	0.0162
3095	Complement factor B	CFB	0.0155
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0153
294	Neprilysin	MME	0.015
824	Sodium-dependent serotonin transporter	SLC6A4	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
614	Progesterone receptor	PGR	0.0147
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0147
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0143
4604	Liver carboxylesterase 1	CES1	0.014
3947	Xanthine dehydrogenase/oxidase	XDH	0.0136
6151	Monocarboxylate transporter 10	SLC16A10	0.0136
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0132
556	Alpha-1A adrenergic receptor	ADRA1A	0.0132
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0132
29	Tubulin beta-1 chain	TUBB1	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
2517	Subtilisin BPN'	apr	0.0129
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0128
831	D(2) dopamine receptor	DRD2	0.0127
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0127
232	Corticosteroid-binding globulin	SERPINA6	0.0127
140	30S ribosomal protein S9	rpsI	0.0127
6719	30S ribosomal protein S9	rpsI	0.0127
6725	30S ribosomal protein S9	rpsI	0.0127
124	Histamine H2 receptor	HRH2	0.012
467	Delta-type opioid receptor	OPRD1	0.012
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.012
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
159	Penicillin-binding protein 2B	penA	0.0119
6121	Penicillin-binding protein 2B	penA	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
318	Alpha-2A adrenergic receptor	ADRA2A	0.0118
723	Cytosolic phospholipase A2	PLA2G4A	0.0117
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0117
161	Tubulin beta chain	TUBB	0.0117
312	Tubulin beta chain	TUB2	0.0117
2016	Dipeptidase 1	DPEP1	0.0115
4681	Aminopeptidase	Not Available	0.0114
3526	Pseudomonalisin	pcp	0.0114
338	DNA polymerase	UL30	0.0112
379	DNA polymerase	UL54	0.0112
697	DNA polymerase	ORF28	0.0112
2482	DNA polymerase	43	0.0112
4104	DNA polymerase	BALF5	0.0112
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0111
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.011
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.011
22	30S ribosomal protein S4	rpsD	0.0109
6714	30S ribosomal protein S4	rpsD	0.0109
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0107
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0104
756	Sex hormone-binding globulin	SHBG	0.0102
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0102
260	Cytochrome P450 51	ERG11	0.0101
761	Cytochrome P450 51	ERG11	0.0101
3163	Cytochrome P450 51	cyp51	0.0101
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0101
6182	Cytochrome P450 2J2	CYP2J2	0.0101
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0101
6599	HTH-type transcriptional regulator ttgR	ttgR	0.01
844	Epidermal growth factor receptor	EGFR	0.01
477	DNA topoisomerase 4 subunit A	parC	0.01
886	DNA topoisomerase 4 subunit A	parC	0.01
6226	DNA topoisomerase 4 subunit A	parC	0.01
696	Kappa-type opioid receptor	OPRK1	0.01
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0099
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0099
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0099
404	DNA gyrase subunit A	gyrA	0.0098
6224	DNA gyrase subunit A	gyrA	0.0098
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
632	Alpha-1B adrenergic receptor	ADRA1B	0.0096
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6231	Pepsin A	PGA3	0.0093
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
737	Mineralocorticoid receptor	NR3C2	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
645	Penicillin-binding protein 1A	mrcA	0.0091
5805	Penicillin-binding protein 1A	ponA	0.0091
6185	Penicillin-binding protein 1A	mrcA	0.0091
6799	Penicillin-binding protein 1A	pbpA	0.0091
5818	Folate receptor alpha	FOLR1	0.0091
468	Cytochrome P450 4A11	CYP4A11	0.009
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0089
638	D(3) dopamine receptor	DRD3	0.0089
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0088
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0088
5626	Nucleoside diphosphate kinase B	NME2	0.0088
6220	Aryl hydrocarbon receptor	AHR	0.0087
2300	Lysozyme	E	0.0087
3633	Lysozyme	R	0.0087
5597	Lysozyme	17	0.0087
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0087
543	Penicillin-binding protein 1B	mrcB	0.0086
6186	Penicillin-binding protein 1B	ponB	0.0086
6822	Penicillin-binding protein 1b	pbp1b	0.0086
6844	Penicillin-binding protein 1b	pbp1b	0.0086
23	D(1A) dopamine receptor	DRD1	0.0085
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0085
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0084
4237	50S ribosomal protein L22	rplV	0.0084
273	Apoptosis regulator Bcl-2	BCL2	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0083
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0083
146	Androgen receptor	AR	0.0083
1650	Heme carrier protein 1	SLC46A1	0.0082
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0081
713	Sodium-dependent dopamine transporter	SLC6A3	0.0079
293	Gamma-glutamyl hydrolase	GGH	0.0079
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0077
380	Cytochrome P450 17A1	CYP17A1	0.0076
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0076
6149	Solute carrier family 22 member 10	SLC22A10	0.0076
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0076
378	Alpha-2C adrenergic receptor	ADRA2C	0.0074
818	50S ribosomal protein L10	rplJ	0.0074
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0073
1852	Microtubule-associated protein 2	MAP2	0.0072
629	Alpha-2B adrenergic receptor	ADRA2B	0.0072
5294	Nucleoside diphosphate kinase A	NME1	0.0072
2539	Tubulin alpha-1 chain	TUBA4A	0.0072
3923	Cholinesterase	BCHE	0.0071
766	Beta-2 adrenergic receptor	ADRB2	0.0071
4238	50S ribosomal protein L4	rplD	0.0071
5578	50S ribosomal protein L4	rplD	0.0071
6173	50S ribosomal protein L4	rplD	0.0071
6219	50S ribosomal protein L4	rplD	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
6085	Fatty acid-binding protein, intestinal	FABP2	0.0069
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0068
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0068
5924	Microtubule-associated protein 4	MAP4	0.0068
5923	Microtubule-associated protein tau	MAPT	0.0068
705	Glutamate receptor 1	GRIA1	0.0067
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0067
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0066
633	Penicillin-binding proteins 1A/1B	pbpA	0.0065
811	Translocator protein	TSPO	0.0065
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
183	Vascular endothelial growth factor A	VEGFA	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0065
33	Cystine/glutamate transporter	SLC7A11	0.0064
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0062
789	Alpha-1D adrenergic receptor	ADRA1D	0.0061
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.006
725	5-hydroxytryptamine 1D receptor	HTR1D	0.006
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.006
274	Muscarinic acetylcholine receptor M5	CHRM5	0.006
275	Arachidonate 5-lipoxygenase	ALOX5	0.0059
365	Dihydrofolate reductase	DHFR	0.0059
2381	Dihydrofolate reductase	DFR1	0.0059
2833	Dihydrofolate reductase	Not Available	0.0059
2931	Dihydrofolate reductase	folA	0.0059
3544	Dihydrofolate reductase	folA	0.0059
3682	Dihydrofolate reductase	folA	0.0059
6642	Dihydrofolate reductase	folA	0.0059
6756	Dihydrofolate reductase	dfrA	0.0059
1050	Bile salt sulfotransferase	SULT2A1	0.0058
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0058
869	Estrogen receptor beta	ESR2	0.0058
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0058
432	D(4) dopamine receptor	DRD4	0.0057
4192	DNA topoisomerase 2-beta	TOP2B	0.0057
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
24	Thymidylate synthase	TMP1	0.0057
359	Thymidylate synthase	TYMS	0.0057
2626	Thymidylate synthase	thyA	0.0057
2729	Thymidylate synthase	thyA	0.0057
5352	Thymidylate synthase	THYA	0.0057
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0056
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0056
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0056
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0055
5787	Angiopoietin-1 receptor	TEK	0.0055
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0054
6043	Putative G-protein coupled receptor 44	GPR44	0.0054
407	Vascular endothelial growth factor receptor 2	KDR	0.0054
5353	Glutamate decarboxylase alpha	gadA	0.0054
504	Mast/stem cell growth factor receptor	KIT	0.0053
461	Glycine receptor subunit alpha-3	GLRA3	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
465	Calmodulin	CALM1	0.0053
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0053
6138	Multidrug resistance protein 3	ABCB4	0.0052
4120	NADPH--cytochrome P450 reductase	POR	0.0052
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0051
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0051
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0051
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0051
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0051
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0051
777	Tumor necrosis factor	TNF	0.005
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.005
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.005
768	FK506-binding protein 1A	FKBP1A	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
26	Vascular endothelial growth factor receptor 3	FLT4	0.0049
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0048
122	P2Y purinoceptor 12	P2RY12	0.0048
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0048
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0048
1867	Major prion protein	PRNP	0.0047
284	DNA-directed RNA polymerase beta chain	rpoB	0.0047
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0047
716	5-hydroxytryptamine 7 receptor	HTR7	0.0047
3587	Gastrotropin	FABP6	0.0047
1405	Thiopurine S-methyltransferase	TPMT	0.0047
32	Vascular endothelial growth factor receptor 1	FLT1	0.0047
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0046
193	Beta-1 adrenergic receptor	ADRB1	0.0046
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
2449	Tubulin alpha-3 chain	TUBA1A	0.0045
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0044
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0044
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0043
130	Prostacyclin synthase	PTGIS	0.0043
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0042
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
814	Ryanodine receptor 1	RYR1	0.0042
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0042
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0042
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0041
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0041
1656	CYP2B protein	CYP2B	0.0041
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6209	30S ribosomal protein S19	rpsS	0.0041
6712	30S ribosomal protein S19	rpsS	0.0041
6726	30S ribosomal protein S19	rpsS	0.0041
6207	30S ribosomal protein S14	rpsN	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0041
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0041
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.004
1629	Transcription factor AP-1	JUN	0.004
1353	DNA topoisomerase 1	TOP1	0.004
3552	DNA topoisomerase 1	topA	0.004
239	Coagulation factor X	F10	0.0039
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0039
3932	Glutathione S-transferase A2	GSTA2	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
5482	Sialidase-2	NEU2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
558	Solute carrier family 12 member 1	SLC12A1	0.0039
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
1757	Myeloperoxidase	MPO	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
4773	Deoxycytidine kinase	DCK	0.0038
6168	Solute carrier family 22 member 16	SLC22A16	0.0038
3941	Amine oxidase [flavin-containing] A	MAOA	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
6212	Tubulin gamma-1 chain	TUBG1	0.0037
6210	Tubulin delta chain	TUBD1	0.0037
6211	Tubulin epsilon chain	TUBE1	0.0037
489	Monocarboxylate transporter 2	SLC16A7	0.0037
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0036
54	Prothrombin	F2	0.0036
6014	Cytochrome P450 2A13	CYP2A13	0.0036
427	Substance-P receptor	TACR1	0.0036
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0036
904	Glutathione S-transferase P	GSTP1	0.0036
3426	Glutamine synthetase	glnA	0.0036
3987	Glutamine synthetase	GLUL	0.0036
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0036
2021	Thrombomodulin	THBD	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
856	Vitamin D3 receptor	VDR	0.0035
5300	Antigen peptide transporter 1	TAP1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
115	Penicillin-binding protein 2	mrdA	0.0035
6069	Penicillin-binding protein 2	mrdA	0.0035
6118	Penicillin-binding protein 2	penA	0.0035
6187	Penicillin-binding protein 2	pbpA	0.0035
6686	Penicillin-binding protein 2	pbp2	0.0035
6939	Penicillin-binding protein 2	mrdA	0.0035
7163	Penicillin-binding protein 2	pbpA	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1483	Membrane copper amine oxidase	AOC3	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0034
1010	Cytochrome P450 51A1	CYP51A1	0.0034
992	Protein tyrosine kinase 2 beta	PTK2B	0.0034
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
474	Acetylcholinesterase	ACHE	0.0033
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0033
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0033
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0033
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
4760	Mll3241 protein	mll3241	0.0032
1	Peptidoglycan synthetase ftsI	ftsI	0.0032
4155	Peptidoglycan synthetase ftsI	ftsI	0.0032
908	Glutathione S-transferase theta-1	GSTT1	0.0032
6218	Pannexin-1	PANX1	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
165	FL cytokine receptor	FLT3	0.0032
3086	Plasmepsin-2	Not Available	0.0032
295	Carbonic anhydrase 1	CA1	0.0032
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
163	D(1B) dopamine receptor	DRD5	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0031
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
70	Type-1 angiotensin II receptor	AGTR1	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
244	Angiotensin-converting enzyme	ACE	0.003
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.003
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
527	Prostacyclin receptor	PTGIR	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
94	5-hydroxytryptamine 4 receptor	HTR4	0.0029
672	Prostaglandin F2-alpha receptor	PTGFR	0.0028
3809	Estrogen-related receptor gamma	ESRRG	0.0028
571	Melatonin receptor type 1A	MTNR1A	0.0028
362	Melatonin receptor type 1B	MTNR1B	0.0028
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0028
1313	Lactoylglutathione lyase	GLO1	0.0028
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0027
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0027
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0027
5126	Arginase	rocF	0.0027
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0027
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
6102	Arylamine N-acetyltransferase 2	NAT2	0.0027
6042	Prostaglandin reductase 2	PTGR2	0.0027
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0026
6171	Solute carrier family 28 member 3	SLC28A3	0.0026
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0026
2599	Tyrosine-protein kinase HCK	HCK	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0026
6837	Serine/threonine-protein kinase 17B	STK17B	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0026
49	Endothelin B receptor	EDNRB	0.0026
2391	Ferrochelatase	hemH	0.0025
6502	Ferrochelatase	DKFZp686P18130	0.0025
1591	Ferrochelatase, mitochondrial	FECH	0.0025
740	Argininosuccinate synthase	ASS1	0.0025
865	Argininosuccinate synthase	ASS1	0.0025
2680	Argininosuccinate synthase	argG	0.0025
3194	Argininosuccinate synthase	argG	0.0025
1792	Tissue-type plasminogen activator	PLAT	0.0025
823	Fibroblast growth factor receptor 2	FGFR2	0.0025
2112	Toll-like receptor 9	TLR9	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
469	Annexin A1	ANXA1	0.0024
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6228	Nuclear receptor coactivator 1	NCOA1	0.0024
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3810	Catechol O-methyltransferase	COMT	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6241	Nuclear receptor coactivator 2	NCOA2	0.0024
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0023
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0023
131	Synaptic vesicular amine transporter	SLC18A2	0.0023
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0023
4217	Telomerase reverse transcriptase	TERT	0.0023
4311	tRNA	TRDMT1	0.0023
4325	tRNA	trmD	0.0023
4328	tRNA	trmD	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0023
1039	Histone deacetylase 9	HDAC9	0.0023
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0022
6500	Phospholipase A2	PLA2G1B	0.0022
6174	50S ribosomal protein L32	rpmF	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0022
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0022
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0022
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0022
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0022
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0022
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0022
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0022
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0022
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0022
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0022
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0022
6559	Cytochrome c oxidase subunit 2	ctaC	0.0022
6669	Cytochrome c oxidase subunit 2	ctaC	0.0022
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0022
6558	Cytochrome c oxidase subunit 1	ctaD	0.0022
494	Caspase-1	CASP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
3939	Amine oxidase [flavin-containing] B	MAOB	0.0022
921	Glutamate receptor 2	GRIA2	0.0022
1196	Complement decay-accelerating factor	CD55	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0021
1507	Cytochrome c	CYCS	0.0021
702	UMP-CMP kinase	CMPK1	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
4122	Histone deacetylase 2	HDAC2	0.002
16	Adenosine A1 receptor	ADORA1	0.002
2540	Choloylglycine hydrolase	cbh	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.002
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0019
1525	Heparin-binding growth factor 2	FGF2	0.0019
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
1178	Adenosine A2a receptor	ADORA2A	0.0019
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
84	Nuclear receptor 0B1	NR0B1	0.0019
6501	Fatty acid-binding protein, liver	FABP1	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
780	Retinoic acid receptor RXR-gamma	RXRG	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0019
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0019
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0019
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
2077	Caspase-3	CASP3	0.0018
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0018
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
65	Matrix metalloproteinase-9	Not Available	0.0018
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0018
683	Potassium transporter	GK0582	0.0018
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0018
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1517	Beta-3 adrenergic receptor	ADRB3	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
88	Retinoic acid receptor RXR-beta	RXRB	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
76	Nitric-oxide synthase, brain	NOS1	0.0017
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
7	Nitric oxide synthase, inducible	NOS2	0.0017
517	Alcohol dehydrogenase 1C	ADH1C	0.0017
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0016
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0016
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3856	Fibroblast growth factor receptor 3	FGFR3	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0016
3233	Bile acid receptor	NR1H4	0.0015
751	Potassium channel subfamily K member 6	KCNK6	0.0015
319	Opioid receptor, sigma 1	OPRS1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1630	Integrin beta-2	ITGB2	0.0015
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
1541	Metalloproteinase	mmp20	0.0014
976	Platelet glycoprotein IX	GP9	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
936	Ephrin type-A receptor 2	EPHA2	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
2216	Fibroblast growth factor receptor 4	FGFR4	0.0014
896	Glutathione S-transferase Mu 1	GSTM1	0.0014
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0014
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0014
3904	Alanine aminotransferase 2	GPT2	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
174	Sigma 1-type opioid receptor	SIGMAR1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
6044	Serum paraoxonase/lactonase 3	PON3	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0011
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0011
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1192	Sulfotransferase 1A1	SULT1A1	0.0011
4878	Glycoprotein hormones alpha chain	CGA	0.0011
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0011
1072	Granzyme B	GZMB	0.0011
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0011
4877	Beta-mannanase	man	0.0011
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
4856	CD209 antigen	CD209	0.0011
4889	Ig epsilon chain C region	IGHE	0.0011
4189	Alpha-galactosidase A	GLA	0.0011
4869	Major capsid protein	A430L	0.0011
4852	Reticulon-4 receptor	RTN4R	0.0011
4880	Membrane cofactor protein	CD46	0.0011
4845	ADAM 33	ADAM33	0.0011
757	Fusion glycoprotein F0	F	0.0011
4875	Fusion glycoprotein F0	F	0.0011
4721	Beta-1,4-mannanase	manA	0.0011
4850	Beta-2-glycoprotein 1	APOH	0.0011
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0011
1354	Beta-glucuronidase	GUSB	0.0011
442	Envelope glycoprotein	gp41	0.0011
4859	Envelope glycoprotein	env	0.0011
3352	Structural polyprotein	Not Available	0.0011
3628	Structural polyprotein	Not Available	0.0011
4892	Structural polyprotein	Not Available	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
572	Integrin alpha-L	ITGAL	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
569	Retinal dehydrogenase 2	ALDH1A2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
267	Plasminogen activator inhibitor 1	SERPINE1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1864	RET proto-oncogene	RET	0.0011
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.001
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.001
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
5934	Cytochrome P450 26A1	CYP26A1	0.001
793	T-cell surface antigen CD2	CD2	0.001
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.001
4861	Interleukin-6 receptor alpha chain	IL6R	0.001
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.001
3837	Cytokine receptor common beta chain	CSF2RB	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1379	Interleukin-12 subunit beta	IL12B	0.0009
4890	Hemagglutinin	HA	0.0009
6566	Hemagglutinin	Not Available	0.0009
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0009
6858	Inactive carboxylesterase 4	CES1P1	0.0009
1184	Interferon beta	IFNB1	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0009
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0009
2297	Genome polyprotein	Not Available	0.0009
2322	Genome polyprotein	Not Available	0.0009
2694	Genome polyprotein	Not Available	0.0009
2719	Genome polyprotein	Not Available	0.0009
2860	Genome polyprotein	Not Available	0.0009
2928	Genome polyprotein	Not Available	0.0009
3160	Genome polyprotein	Not Available	0.0009
3260	Genome polyprotein	Not Available	0.0009
4783	Genome polyprotein	Not Available	0.0009
5726	Genome polyprotein	Not Available	0.0009
5779	Genome polyprotein	Not Available	0.0009
5867	Genome polyprotein	Not Available	0.0009
6253	Genome polyprotein	Not Available	0.0009
6301	Genome polyprotein	Not Available	0.0009
6380	Genome polyprotein	Not Available	0.0009
6381	Genome polyprotein	Not Available	0.0009
6437	Genome polyprotein	Not Available	0.0009
6520	Genome polyprotein	Not Available	0.0009
6521	Genome polyprotein	Not Available	0.0009
6652	Genome polyprotein	Not Available	0.0009
6734	Genome polyprotein	Not Available	0.0009
6735	Genome polyprotein	Not Available	0.0009
6736	Genome polyprotein	Not Available	0.0009
6737	Genome polyprotein	Not Available	0.0009
6738	Genome polyprotein	Not Available	0.0009
6739	Genome polyprotein	Not Available	0.0009
6744	Genome polyprotein	Not Available	0.0009
6748	Genome polyprotein	Not Available	0.0009
6894	Genome polyprotein	Not Available	0.0009
6898	Genome polyprotein	Not Available	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
1859	Prostatic acid phosphatase	ACPP	0.0009
3444	Cyanovirin-N	Not Available	0.0009
3140	Hemagglutinin-neuraminidase	HN	0.0009
3609	Hemagglutinin-neuraminidase	HN	0.0009
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4787	Envelope glycoprotein gp160	env	0.0008
4820	Envelope glycoprotein gp160	env	0.0008
5727	Envelope glycoprotein gp160	env	0.0008
4666	Fucose-binding lectin PA-IIL	lecB	0.0008
2372	Bifunctional tail protein	9	0.0008
2207	Rhodopsin	RHO	0.0008
2232	Interleukin-5	IL5	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
1593	Mucin-2	MUC2	0.0008
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0008
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0008
6432	Transporter	snf	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0008
554	Low-density lipoprotein receptor	LDLR	0.0008
852	Heparin cofactor 2	SERPIND1	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
1439	Lactotransferrin	LTF	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
1243	Cathepsin D	CTSD	0.0007
595	Fibrinogen alpha chain	FGA	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
958	Insulin-like growth factor 1 receptor	IGF1R	0.0007
2430	Chondroitinase B	cslB	0.0007
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0007
6307	Ig gamma-2 chain C region	IGHG2	0.0007
2581	Chondroitinase AC	cslA	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
164	Histamine H4 receptor	HRH4	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6847	Lactase-phlorizin hydrolase	LCT	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
714	Glutathione reductase, mitochondrial	GSR	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3814	Complement C1r subcomponent	C1R	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
309	Antithrombin-III	SERPINC1	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
4785	Ig gamma-1 chain C region	IGHG1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
6146	High affinity copper uptake protein 1	SLC31A1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
1275	Estrogen sulfotransferase	SULT1E1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
3957	Adenosine deaminase	ADA	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB06335 - Saxagliptin

Targets

Enzymes

Transporters

Predictions