DT-Web

DB01026 - Ketoconazole


Identification
Name Ketoconazole
Accession Number DB01026 (APRD00401)
Type small molecule
Description Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 531.431
Groups approved
Monoisotopic Weight 530.148760818
Pharmacology
Indication For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Mechanism of action Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
Absorption Moderate
Protein binding 99% (in vitro, plasma protein binding)
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Affected organisms
  • Fungi
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol Ketoconazole may increase the anticoagulant effect of acenocoumarol.
Alfentanil Ketoconazole may increase the effect and toxicity of alfentanil.
Alfuzosin The antifungal increases the effect of alfuzosin
Almotriptan This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Alprazolam Ketoconazole may increase the effect of the benzodiazepine, alprazolam.
Aluminium Aluminum-containing antacids may decrease the effect of ketoconazole.
Amitriptyline Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of amitriptyline by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if ketoconazole is initiated, discontinued or dose changed.
Anisindione Ketoconazole may increase the anticoagulant effect of anisindione.
Apixaban Avoid combination. Otherwise, ketoconazole will likely increase apixaban serum concentration.
Aprepitant This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Aripiprazole Ketoconazole may increase the effect of aripiprazole.
Artemether Concurrent oral administration of ketoconazole, a potent CYP3A4 inhibitor, with a single dose of Coartem Tablets resulted in a moderate increase in exposure to artemether, DHA, and lumefantrine in a study of 15 healthy subjects.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Avanafil Co-administration with the strong CYP3A4 inhibitor ketoconazole resulted in an approximate 13-fold increase in AUC0-inf and 3.1-fold increase in Cmax.
Bedaquiline Strong CYP3A4 inhibitors may increase exposure of bedaquiline. Monitor concomitant therapy closely.
Bosentan Ketoconazole may increase the effect and toxicity of bosentan.
Bosutinib Strong CYP3A4 inhibitors may increase levels of bosutinib. Monitor concomitant therapy closely.
Bromazepam Ketoconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if ketoconazole is initiated, discontinued or dose changed.
Budesonide Ketoconazole may increase levels/effect of budesonide.
Cabazitaxel Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Calcium Calcium-containing antacids may decrease the absorption of ketoconazole.
Carbamazepine Ketoconazole may increase the effect of carbamazepine.
Cerivastatin Increased risk of myopathy/rhabdomyolysis
Chlordiazepoxide Ketoconazole may increase the effect of the benzodiazepine, chlordiazepoxide.
Ciclesonide Increased effects/toxicity of ciclesonide
Cilostazol Ketoconazole may increase the effect of cilostazol.
Cimetidine The H2-receptor antagonist, cimetidine, may decrease the absorption of ketoconazole.
Cinacalcet Ketoconazole may increase the effect and toxicity of cinacalcet.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clobazam Clobazam may increase levels by affecting CYP2C19 metabolism. Interaction is significant so monitor closely. Dose adjustment may be necessary.
Clonazepam Ketoconazole may increase the effect of the benzodiazepine, clonazepam.
Clorazepate Ketoconazole may increase the effect of the benzodiazepine, clorazepate.
Conivaptan Antifungal Agents (Azole Derivatives, Systemic) may decrease the metabolism of Conivaptan. Concomitant use of conivaptan with strong CYP3A4 inhibitors (e.g., azole antifungals) is contraindicated.
Crizotinib Strong CYP3A4 inhibitors may increase levels of crizotinib. Monitor concomitant therapy closely.
Cyclosporine Ketoconazole may increase the effect of cyclosporine.
Dabigatran etexilate Coadministration with a strong p-glycoprotein inhibitor may increase the level or effect of dabigatran. Monitor closely for adverse effects.
Dabrafenib Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Dantrolene Ketoconazole may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if ketoconazole is initiated, discontinued or dose changed.
Darifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Diazepam Ketoconazole may increase the effect of the benzodiazepine, diazepam.
Dicumarol Ketoconazole may increase the anticoagulant effect of dicumarol.
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Docetaxel Ketoconazole may increase the serum levels and toxicity of docetaxel.
Dofetilide This strong CYP3A4 inhibitor increases the effect and toxicity of dofetilide
Dronedarone Ketoconazole is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Eletriptan This potent CYP3A4 inhibitor increases the effect and toxicity of the triptan
Eplerenone Ketoconazole, a CYP3A4 inhibitor, may increase the effect and toxicity of eplerenone.
Ergotamine Possible ergotism and severe ischemia with this combination.
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Esomeprazole The proton pump inhibitor, esomeprazole, may decrease the absorption of ketoconazole.
Estazolam Ketoconazole may increase the effect of the benzodiazepine, estazolam.
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Etravirine Etravirine, when used concomitantly with Ketoconazole (and other azole derivatives), may experience an increase in serum concentration. Ketoconazole (and other azole derivatives), when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor etravirine therapy for toxicity.
Everolimus Ketoconazole may increase everolimus levels/toxicity.
Famotidine The H2-receptor antagonist, famotidine, may decrease the absorption of ketoconazole.
Fentanyl Ketoconazole may increase levels/toxicity of fentanyl.
Fesoterodine Ketoconazole is a potent CYP3A4 inhibitor thus reducing clearance. Avoid concomitant use with fesoterodine.
Fingolimod Exposure is increased by 70% during concomitant use with systemic ketoconazole, and risk of adverse reactions is greater.
Flurazepam Ketoconazole may increase the effect of the benzodiazepine, flurazepam.
Fluticasone furoate Strong CYP3A4 inhibitors may increase levels of fluticasone furoate. Monitor concomitant therapy closely.
Galantamine Ketoconazole increases the effect and toxicity of galantamine
Gefitinib This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Glimepiride Ketoconazole increases the effect of rosiglitazone
Halazepam Ketoconazole may increase the effect of the benzodiazepine, halazepam.
Haloperidol Ketoconazole may increase the effect and toxicity of haloperidol.
Iloperidone Ketoconazole is a strong CYP3A4 inhibitor that increases serum concentration of iloperidone and likelihood of observing adverse effects such as QT prolongation. Reduce dose of iloperidone by 50%
Imatinib Ketoconazole may increase the levels of imatinib.
Imipramine Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of imipramine by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if ketoconazole is initiated, discontinued or dose changed.
Indacaterol Strong CYP3A4 inhibitors increase levels of indacaterol. Consider alternate therapy.
Indinavir Indinavir may increase the serum concentration of ketoconazole. Ketoconazole may increase the serum concentration of indinavir. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if either agent is initiated, discontinued or dose changed.
Irinotecan Ketoconazole increases the effect and toxicity of irinotecan
Isoniazid Isoniazid decreases the effect of ketoconazole
Ivacaftor Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Lansoprazole The proton pump inhibitor, lansoprazole, may decrease the absorption of ketoconazole.
Levomilnacipran Strong CYP3A4 inhibitors may increase exposure levomilnacipran.
Lovastatin Increased risk of myopathy/rhabdomyolysis
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Magnesium oxide The antacid, magnesium oxide, may decrease the effect of ketoconazole by decreasing its absorption.
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methylprednisolone The imidazole, ketoconazole, may increase the effect and toxicity of the corticosteroid, methylprednisolone.
Midazolam Ketoconazole may increase the effect of the benzodiazepine, midazolam.
Mirabegron Concomitant therapy with p-glycoprotein and strong CYP3A4 inhibitors may increase levels of mirabegron. Monitor concomitant therapy closely.
Nevirapine Nevirapine, a strong CYP3A4 inducer, may decrease the serum concentration of ketoconazole by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of ketoconazole if nevirapine is initiated, discontinued or dose changed.
Nizatidine The H2-receptor antagonist, nizatidine, may decrease the absorption of ketoconazole.
Nortriptyline Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of nortriptyline by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if ketoconazole is initiated, discontinued or dose changed.
Omeprazole The proton pump inhibitor, omeprazole, may decrease the absorption of ketoconazole.
Ospemifene Ketoconazole, a strong CYP3A4 inhibitor increases the systemic exposure of ospemifene by 1.4-fold. Administration of ketoconazole chronically with ospemifene may increase the risk of OSPHENA-related adverse reactions.
Pantoprazole The proton pump inhibitor, pantoprazole, may decrease the absorption of ketoconazole.
Pazopanib Ketoconazole is a strong inhibitor of CYP3A4 thus increasing exposure of pazopanib by 120% in healthy subjects.
Pimozide Increased risk of cardiotoxicity and arrhythmias
Pioglitazone Ketoconazole increases the effect of pioglitazone
Pomalidomide Strong CYP3A4 inhibitors may increase levels of pomalidomide. Concomitant therapy should be avoided.
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Prasugrel Ketoconazole is a potent inhibitor of CYP3A4 which decreases the Cmax of prasugrel due to a reduction of prasugrel bioactivation. However, there was no reduction of inhibition of platelet aggregation.
Prednisolone The imidazole, ketoconazole, may increase the effect and toxicity of the corticosteroid, prednisolone.
Prednisone The imidazole, ketoconazole, may increase the effect and toxicity of the corticosteroid, prednisone.
Quazepam Ketoconazole may increase the effect of the benzodiazepine, quazepam.
Quetiapine Ketoconazole may increase the therapeutic and adverse effects of quetiapine.
Quinidine Ketoconazole may increase the effect and toxicity of quinidine.
Quinidine barbiturate Ketoconazole may increase the effect and toxicity of quinidine barbiturate.
Rabeprazole The proton pump inhibitor, rabeprazole, may decrease the absorption of ketoconazole.
Ramelteon Ketoconazole may increase the serum levels and toxicity of ramelteon.
Ranitidine The H2-receptor antagonist, ranitidine, may decrease the absorption of ketoconazole.
Ranolazine Increased levels of ranolazine - risk of toxicity
Regorafenib Strong CYP3A4 inhibitors may increase levels of regorafenib.
Rifampin Rifampin may decrease the effect of ketoconazole.
Ritonavir Ketoconazole may increase the effect and toxicity of ritonavir.
Rivaroxaban Use of rivaroxaban with agents that are strong inhibitors of both CYP3A4 and P-glycoproteins are contraindicated.
Roflumilast Increases roflumilast levels.
Rosiglitazone Ketoconazole increases the effect of rosiglitazone
Ruxolitinib Strong CYP3A4 inhibitors may increase levels of ruxolitinib. Consider alternate therapy.
Saquinavir Ketoconazole may increase the effect and toxicity of saquinavir.
Saxagliptin Ketoconazole is a strong inhibitor of CYP3A4/5 which increases exposure of saxagliptin. The exposure of the active metabolite, 5-hydroxy saxagliptin, also decreases. Decrease dose of saxagliptin to 2.5 mg per day.
Sibutramine Ketoconazole increases the levels and toxicity of sibutramine
Sildenafil Ketoconazole may increase the effect and toxicity of sildenafil.
Silodosin Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of silodosin by decreasing its metabolism thus increases the potential for adverse side effects
Simvastatin Increased risk of myopathy/rhabdomyolysis
Sirolimus Ketoconazole may increase the effect and toxicity of sirolimus.
Solifenacin This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Sucralfate Sucralfate may decrease the absorption of ketoconazole.
Sunitinib Possible increase in sunitinib levels
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Ketoconazole. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Ketoconazole is initiated, discontinued or if the dose is changed.
Tacrolimus The antifungal, Ketoconazole, may increase serum concentrations of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Ketoconzole therapy is initiated, discontinued or altered.
Tadalafil Ketoconazole may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Ketoconazole may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Ketoconazole may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Ketoconazole is initiated, discontinued or dose changed.
Tamsulosin Ketoconazole, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Ketoconzole is initiated, discontinued, or dose changed.
Telaprevir Strong CYP3A4 inhibitors increase exposure of telaprevir.
Telithromycin Ketoconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Ketoconazole may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Ketoconazole is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiothixene The strong CYP1A2 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ketoconazole is initiated, discontinued or dose changed.
Tiagabine The strong CYP3A4 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Ketoconazole is initiated, discontinued or dose changed.
Tipranavir Tipranavir may increase the serum concentration of Ketoconazole.
Tizanidine Ketoconazole may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolbutamide Ketoconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Ketoconazole is initiated, discontinued or dose changed.
Tolterodine Ketoconazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Ketoconazole is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan by 82%.
Topotecan The p-glycoprotein inhibitor, Ketoconazole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Torasemide Ketoconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Ketoconazole is initiated, discontinued or dose changed.
Tramadol Ketoconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Ketoconazole may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Ketoconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Ketoconazole is initiated, discontinued or dose changed.
Triazolam Ketoconazole may increase the effect of the benzodiazepine, triazolam.
Trimethoprim The strong CYP2C9 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Ketoconazole is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Ketoconazole is initiated, discontinued or dose changed.
Ulipristal Concomitant therapy with strong CYP3A4 inhibitors may increase plasma concentrations of ulipristal. Avoid combination therapy.
Valdecoxib Ketoconazole may increase the effect and toxicity of valdecoxib.
Vardenafil Ketoconazole, a potent CYP3A4 inhibitor, may decrease the metabolism and clearance of Vardenafil. Concomitant therapy is contraindicated.
Vemurafenib Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine Ketoconazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Ketoconazole is initiated, discontinued, or dose changed.
Verapamil Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Ketoconazole is initiated, discontinued or dose changed.
Vilazodone CYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone. imit maximum adult vilazodone dose to 20 mg/day in patients receiving strong CYP3A4 inhibitors.
Vinblastine Ketoconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Ketoconazole is initiated, discontinued or dose changed.
Vincristine Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Ketoconazole is initiated, discontinued or dose changed.
Vinorelbine Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Ketoconazole is initiated, discontinued or dose changed.
Voriconazole Ketoconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if ketoconazole is initiated, discontinued or dose changed.
Warfarin Ketoconazole, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if ketoconazole is initiated, discontinued or dose changed.
Zafirlukast Ketoconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if ketoconazole is initiated, discontinued or dose changed.
Ziprasidone Ketoconazole increases the effect and toxicity of ziprasidone
Zolpidem Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if ketoconazole is initiated, discontinued or dose changed.
Zonisamide Ketonconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if ketoconazole is initiated, discontinued or dose changed.
Zopiclone Ketonconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if ketoconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.

Targets


Cytochrome P450 51
Name Cytochrome P450 51
Gene Name ERG11
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Agut J, Palacin C, Sacristan A, Ortiz JA: Inhibition of ergosterol synthesis by sertaconazole in Candida albicans. Arzneimittelforschung. 1992 May;42(5A):718-20. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Agut J, Palacin C, Salgado J, Casas E, Sacristan A, Ortiz JA: Direct membrane-damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity. Arzneimittelforschung. 1992 May;42(5A):721-4. - Pubmed
  • Croxtall JD, Plosker GL: Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339-59. - Pubmed
  • Borgers M, Degreef H, Cauwenbergh G: Fungal infections of the skin: infection process and antimycotic therapy. Curr Drug Targets. 2005 Dec;6(8):849-62. - Pubmed
  • Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. Epub 2010 Jul 12. - Pubmed
DTHybrid score 0.6355

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.2492
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8288
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8434
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.781
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6703
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5382
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6528
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7676
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor,inducer
References
  • Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4869
Cholesterol side-chain cleavage enzyme, mitochondrial
Name Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name CYP11A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2588
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2665
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2607
Cytochrome P450 26A1
Name Cytochrome P450 26A1
Gene Name CYP26A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1713
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4688
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.547
Cytochrome P450 51A1
Name Cytochrome P450 51A1
Gene Name CYP51A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5649

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score 0.2574
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. - Pubmed
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
  • Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed
  • Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol. 1998 Oct 9;358(3):289-94. - Pubmed
DTHybrid score 0.8079
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score 0.3504

Predictions


Id Partner name Gene Name Score
761 Cytochrome P450 51 ERG11 0.6355
3163 Cytochrome P450 51 cyp51 0.6355
6013 Cytochrome P450 2E1 CYP2E1 0.4059
3811 Cytochrome P450 19A1 CYP19A1 0.2436
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2384
587 Serum albumin ALB 0.2134
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.206
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1685
20 Prostaglandin G/H synthase 1 PTGS1 0.1633
862 Multidrug resistance-associated protein 1 ABCC1 0.1484
6562 Putative cytochrome P450 130 cyp130 0.143
6106 Cytochrome P450 2C18 CYP2C18 0.1406
6145 Solute carrier family 22 member 1 SLC22A1 0.1176
492 Histamine H1 receptor HRH1 0.1169
1729 Solute carrier family 22 member 6 SLC22A6 0.1116
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.1103
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1072
824 Sodium-dependent serotonin transporter SLC6A4 0.0977
6144 Solute carrier family 22 member 2 SLC22A2 0.0975
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0962
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0961
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0932
6142 Solute carrier family 22 member 8 SLC22A8 0.0926
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0894
136 Estrogen receptor ESR1 0.0869
831 D(2) dopamine receptor DRD2 0.0868
6141 Sodium/bile acid cotransporter SLC10A1 0.0851
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0816
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0805
6143 Solute carrier family 22 member 7 SLC22A7 0.0801
502 5-hydroxytryptamine 2A receptor HTR2A 0.0786
290 Prostaglandin G/H synthase 2 PTGS2 0.0785
380 Cytochrome P450 17A1 CYP17A1 0.0774
118 Organic cation/carnitine transporter 2 SLC22A5 0.076
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0755
871 Glucocorticoid receptor NR3C1 0.0748
756 Sex hormone-binding globulin SHBG 0.0747
780 Retinoic acid receptor RXR-gamma RXRG 0.0743
556 Alpha-1A adrenergic receptor ADRA1A 0.0741
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0735
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0721
468 Cytochrome P450 4A11 CYP4A11 0.0717
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0689
2164 Multidrug resistance-associated protein 4 ABCC4 0.0667
6031 Cytochrome P450 3A43 CYP3A43 0.0667
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0656
730 Retinoic acid receptor alpha RARA 0.0649
88 Retinoic acid receptor RXR-beta RXRB 0.0647
847 Mu-type opioid receptor OPRM1 0.064
229 Retinoic acid receptor beta RARB 0.0638
766 Beta-2 adrenergic receptor ADRB2 0.0638
331 Retinol-binding protein I, cellular RBP1 0.0612
146 Androgen receptor AR 0.0605
6147 Solute carrier family 22 member 3 SLC22A3 0.0604
731 HIV-1 protease HIV-1 protease 0.0598
162 Retinoic acid receptor gamma-1 RARG 0.0596
320 5-hydroxytryptamine 1A receptor HTR1A 0.059
737 Mineralocorticoid receptor NR3C2 0.0584
318 Alpha-2A adrenergic receptor ADRA2A 0.0575
459 Retinoic acid receptor RXR-alpha RXRA 0.0568
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0565
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0557
6148 Multidrug resistance-associated protein 7 ABCC10 0.0553
713 Sodium-dependent dopamine transporter SLC6A3 0.0552
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.055
590 5-hydroxytryptamine 2C receptor HTR2C 0.0542
341 5-hydroxytryptamine 3 receptor HTR3A 0.054
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0535
817 DNA topoisomerase 2-alpha TOP2A 0.0534
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0531
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0527
3941 Amine oxidase [flavin-containing] A MAOA 0.0526
193 Beta-1 adrenergic receptor ADRB1 0.0518
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0518
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0517
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0505
467 Delta-type opioid receptor OPRD1 0.05
23 D(1A) dopamine receptor DRD1 0.0491
833 Organic cation/carnitine transporter 1 SLC22A4 0.0487
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0486
632 Alpha-1B adrenergic receptor ADRA1B 0.0485
1024 Solute carrier family 22 member 11 SLC22A11 0.0481
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0479
696 Kappa-type opioid receptor OPRK1 0.0473
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.046
465 Calmodulin CALM1 0.0451
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.045
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0438
564 Cellular retinoic acid-binding protein 1 CRABP1 0.043
6182 Cytochrome P450 2J2 CYP2J2 0.0426
232 Corticosteroid-binding globulin SERPINA6 0.0426
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0425
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0425
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0425
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0424
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0423
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0423
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0414
3947 Xanthine dehydrogenase/oxidase XDH 0.0412
629 Alpha-2B adrenergic receptor ADRA2B 0.0409
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0409
6014 Cytochrome P450 2A13 CYP2A13 0.0403
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0398
885 5-hydroxytryptamine 1B receptor HTR1B 0.0398
638 D(3) dopamine receptor DRD3 0.0392
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0382
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0364
269 Adrenodoxin, mitochondrial FDX1 0.0358
3939 Amine oxidase [flavin-containing] B MAOB 0.0353
3923 Cholinesterase BCHE 0.0341
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0341
6137 Multidrug resistance-associated protein 6 ABCC6 0.0337
94 5-hydroxytryptamine 4 receptor HTR4 0.0337
725 5-hydroxytryptamine 1D receptor HTR1D 0.0333
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0332
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0328
469 Annexin A1 ANXA1 0.0327
6136 Multidrug resistance-associated protein 5 ABCC5 0.0325
122 P2Y purinoceptor 12 P2RY12 0.0325
844 Epidermal growth factor receptor EGFR 0.0323
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.032
6220 Aryl hydrocarbon receptor AHR 0.0319
869 Estrogen receptor beta ESR2 0.0316
614 Progesterone receptor PGR 0.0315
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0313
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0313
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0313
33 Cystine/glutamate transporter SLC7A11 0.0311
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0309
4120 NADPH--cytochrome P450 reductase POR 0.0308
504 Mast/stem cell growth factor receptor KIT 0.0305
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0296
789 Alpha-1D adrenergic receptor ADRA1D 0.0295
4604 Liver carboxylesterase 1 CES1 0.0291
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0289
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0285
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0274
477 DNA topoisomerase 4 subunit A parC 0.0272
886 DNA topoisomerase 4 subunit A parC 0.0272
6226 DNA topoisomerase 4 subunit A parC 0.0272
378 Alpha-2C adrenergic receptor ADRA2C 0.0271
404 DNA gyrase subunit A gyrA 0.0268
6224 DNA gyrase subunit A gyrA 0.0268
777 Tumor necrosis factor TNF 0.0268
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0264
36 Insulin receptor INSR 0.0258
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0257
891 Dihydropteroate synthase folP 0.0251
5359 Dihydropteroate synthase folP 0.0251
7175 Dihydropteroate synthase sulI 0.0251
124 Histamine H2 receptor HRH2 0.025
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0248
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0245
432 D(4) dopamine receptor DRD4 0.0244
6167 Organic solute transporter subunit beta OSTB 0.0244
6166 Organic solute transporter subunit alpha OSTA 0.0244
29 Tubulin beta-1 chain TUBB1 0.0243
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0242
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.024
161 Tubulin beta chain TUBB 0.0236
312 Tubulin beta chain TUB2 0.0236
84 Nuclear receptor 0B1 NR0B1 0.0236
373 Transthyretin TTR 0.0235
811 Translocator protein TSPO 0.0234
569 Retinal dehydrogenase 2 ALDH1A2 0.0231
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0228
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0225
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0224
228 Beta platelet-derived growth factor receptor PDGFRB 0.0224
6102 Arylamine N-acetyltransferase 2 NAT2 0.0224
1757 Myeloperoxidase MPO 0.0223
1178 Adenosine A2a receptor ADORA2A 0.0218
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0217
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0216
904 Glutathione S-transferase P GSTP1 0.0216
7 Nitric oxide synthase, inducible NOS2 0.0216
716 5-hydroxytryptamine 7 receptor HTR7 0.0215
1192 Sulfotransferase 1A1 SULT1A1 0.0215
16 Adenosine A1 receptor ADORA1 0.0215
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0214
273 Apoptosis regulator Bcl-2 BCL2 0.0213
611 Retinal dehydrogenase 1 ALDH1A1 0.0213
407 Vascular endothelial growth factor receptor 2 KDR 0.0212
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
606 Cytochrome P450 27, mitochondrial CYP27A1 0.021
4203 Histamine N-methyltransferase HNMT 0.021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0209
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0209
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0209
49 Endothelin B receptor EDNRB 0.0209
70 Type-1 angiotensin II receptor AGTR1 0.0206
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0205
738 Monocarboxylate transporter 1 SLC16A1 0.0204
436 5-hydroxytryptamine 2B receptor HTR2B 0.0203
589 Retinoid-binding protein 7 RBP7 0.0203
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0203
561 Retinol-binding protein II, cellular RBP2 0.0203
1097 Lecithin retinol acyltransferase LRAT 0.0203
753 Retinol-binding protein III, cellular RBP5 0.0203
4073 Retinol dehydrogenase 11 RDH11 0.0203
4074 Retinol dehydrogenase 14 RDH14 0.0203
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0203
863 Cellular retinaldehyde-binding protein RLBP1 0.0203
651 Retinol dehydrogenase 13 RDH13 0.0203
800 Retinol dehydrogenase 12 RDH12 0.0203
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0203
4072 All-trans-retinol 13,14-reductase RETSAT 0.0203
282 Interphotoreceptor retinoid-binding protein RBP3 0.0203
683 Potassium transporter GK0582 0.0203
818 50S ribosomal protein L10 rplJ 0.0198
578 Endothelin-1 receptor EDNRA 0.0197
26 Vascular endothelial growth factor receptor 3 FLT4 0.0195
4228 Keratin, type II cytoskeletal 7 KRT7 0.0194
131 Synaptic vesicular amine transporter SLC18A2 0.0193
4237 50S ribosomal protein L22 rplV 0.0192
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0191
1517 Beta-3 adrenergic receptor ADRB3 0.019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.019
4238 50S ribosomal protein L4 rplD 0.0188
5578 50S ribosomal protein L4 rplD 0.0188
6173 50S ribosomal protein L4 rplD 0.0188
6219 50S ribosomal protein L4 rplD 0.0188
32 Vascular endothelial growth factor receptor 1 FLT1 0.0186
244 Angiotensin-converting enzyme ACE 0.0184
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0183
2808 Chloramphenicol acetyltransferase 3 cat3 0.0182
1629 Transcription factor AP-1 JUN 0.0182
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
1852 Microtubule-associated protein 2 MAP2 0.0182
2449 Tubulin alpha-3 chain TUBA1A 0.0181
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.018
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.018
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.018
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.018
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.018
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0178
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0178
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0177
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0177
1656 CYP2B protein CYP2B 0.0177
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0173
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0173
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0173
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0173
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0173
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0173
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0173
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0172
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0172
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0171
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0171
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.017
427 Substance-P receptor TACR1 0.017
581 Cytochrome P450 2R1 CYP2R1 0.0169
571 Melatonin receptor type 1A MTNR1A 0.0169
362 Melatonin receptor type 1B MTNR1B 0.0169
5923 Microtubule-associated protein tau MAPT 0.0169
5924 Microtubule-associated protein 4 MAP4 0.0169
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0168
482 Glycine receptor subunit alpha-1 GLRA1 0.0168
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0168
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0167
952 Dipeptidyl peptidase 4 DPP4 0.0165
634 Squalene monooxygenase SQLE 0.0165
7196 Squalene monooxygenase ERG1 0.0165
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0164
705 Glutamate receptor 1 GRIA1 0.0163
4122 Histone deacetylase 2 HDAC2 0.0162
627 11-cis retinol dehydrogenase RDH5 0.0161
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0161
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0161
3587 Gastrotropin FABP6 0.0161
6020 Aldehyde oxidase AOX1 0.0161
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.016
6085 Fatty acid-binding protein, intestinal FABP2 0.0158
3932 Glutathione S-transferase A2 GSTA2 0.0158
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0156
921 Glutamate receptor 2 GRIA2 0.0156
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0156
2298 Cytochrome P450-cam camC 0.0154
474 Acetylcholinesterase ACHE 0.0153
528 5-hydroxytryptamine 1E receptor HTR1E 0.0152
1256 5-hydroxytryptamine 6 receptor HTR6 0.015
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0149
2539 Tubulin alpha-1 chain TUBA4A 0.0148
1992 Vitamin D-binding protein GC 0.0147
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0145
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0144
814 Ryanodine receptor 1 RYR1 0.0143
174 Sigma 1-type opioid receptor SIGMAR1 0.0143
163 D(1B) dopamine receptor DRD5 0.0142
856 Vitamin D3 receptor VDR 0.0142
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0141
345 Plasma retinol-binding protein RBP4 0.0141
823 Fibroblast growth factor receptor 2 FGFR2 0.014
295 Carbonic anhydrase 1 CA1 0.0137
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0137
365 Dihydrofolate reductase DHFR 0.0135
2381 Dihydrofolate reductase DFR1 0.0135
2833 Dihydrofolate reductase Not Available 0.0135
2931 Dihydrofolate reductase folA 0.0135
3544 Dihydrofolate reductase folA 0.0135
3682 Dihydrofolate reductase folA 0.0135
6642 Dihydrofolate reductase folA 0.0135
6756 Dihydrofolate reductase dfrA 0.0135
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0135
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0135
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0134
3809 Estrogen-related receptor gamma ESRRG 0.0133
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0132
165 FL cytokine receptor FLT3 0.0132
275 Arachidonate 5-lipoxygenase ALOX5 0.0131
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0131
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.013
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.013
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0129
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0129
511 5-hydroxytryptamine 1F receptor HTR1F 0.0128
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
2112 Toll-like receptor 9 TLR9 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
284 DNA-directed RNA polymerase beta chain rpoB 0.0123
5773 DNA-directed RNA polymerase beta chain rpoB 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
537 ATP synthase delta chain, mitochondrial ATP5D 0.0122
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0122
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0122
68 Cannabinoid receptor 1 CNR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0121
3270 Elongation factor G fusA 0.0119
4192 DNA topoisomerase 2-beta TOP2B 0.0118
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0117
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0117
1050 Bile salt sulfotransferase SULT2A1 0.0116
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0116
6146 High affinity copper uptake protein 1 SLC31A1 0.0116
48 Pyridoxal kinase PDXK 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
976 Platelet glycoprotein IX GP9 0.0114
291 Nitric-oxide synthase, endothelial NOS3 0.0114
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0113
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0112
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0112
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0111
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0109
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0109
1714 Mitogen-activated protein kinase 3 MAPK3 0.0109
239 Coagulation factor X F10 0.0108
3810 Catechol O-methyltransferase COMT 0.0108
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0106
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0105
4311 tRNA TRDMT1 0.0105
4325 tRNA trmD 0.0105
4328 tRNA trmD 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
592 Carbonic anhydrase 4 CA4 0.0105
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0104
1630 Integrin beta-2 ITGB2 0.0104
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0103
518 Peroxidase/catalase T katG 0.0102
6174 50S ribosomal protein L32 rpmF 0.0102
6044 Serum paraoxonase/lactonase 3 PON3 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
319 Opioid receptor, sigma 1 OPRS1 0.0101
768 FK506-binding protein 1A FKBP1A 0.01
1618 High affinity nerve growth factor receptor NTRK1 0.0099
24 Thymidylate synthase TMP1 0.0099
359 Thymidylate synthase TYMS 0.0099
2626 Thymidylate synthase thyA 0.0099
2729 Thymidylate synthase thyA 0.0099
5352 Thymidylate synthase THYA 0.0099
106 Cannabinoid receptor 2 CNR2 0.0098
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0098
594 Thyroxine-binding globulin SERPINA7 0.0098
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0097
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
936 Ephrin type-A receptor 2 EPHA2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0097
563 Thyroid peroxidase TPO 0.0097
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
3856 Fibroblast growth factor receptor 3 FGFR3 0.0096
251 Alcohol dehydrogenase 1A ADH1A 0.0095
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0095
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0095
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0095
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0094
1569 G1/S-specific cyclin-D1 CCND1 0.0094
517 Alcohol dehydrogenase 1C ADH1C 0.0094
751 Potassium channel subfamily K member 6 KCNK6 0.0093
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0091
6432 Transporter snf 0.0091
758 Thyroid hormone receptor alpha THRA 0.009
1353 DNA topoisomerase 1 TOP1 0.0089
3552 DNA topoisomerase 1 topA 0.0089
6043 Putative G-protein coupled receptor 44 GPR44 0.0089
444 Alcohol dehydrogenase 1B ADH1B 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0088
267 Plasminogen activator inhibitor 1 SERPINE1 0.0088
54 Prothrombin F2 0.0088
3830 Calreticulin CALR 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
1275 Estrogen sulfotransferase SULT1E1 0.0085
172 Potassium channel subfamily K member 1 KCNK1 0.0085
484 Tyrosine-protein kinase ABL2 ABL2 0.0085
183 Vascular endothelial growth factor A VEGFA 0.0085
790 DNA polymerase subunit alpha B POLA2 0.0084
3937 Fatty-acid amide hydrolase FAAH 0.0084
1063 Signal transducer and activator of transcription 5B STAT5B 0.0084
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0084
5787 Angiopoietin-1 receptor TEK 0.0084
820 Glycine receptor subunit alpha-2 GLRA2 0.0083
908 Glutathione S-transferase theta-1 GSTT1 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
4103 Proteasome subunit beta type 2 PSMB2 0.0083
4102 Proteasome subunit beta type 5 PSMB5 0.0083
4101 Proteasome subunit beta type 1 PSMB1 0.0083
2236 Casein kinase II subunit alpha CSNK2A1 0.0082
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0082
6034 Hydroxyindole O-methyltransferase ASMT 0.0081
6035 Nuclear receptor ROR-beta RORB 0.0081
6036 Eosinophil peroxidase EPX 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
346 Thyroid hormone receptor beta-1 THRB 0.008
719 Retinoic acid receptor responder protein 1 RARRES1 0.008
770 Retinoic acid-induced protein 3 GPRC5A 0.008
1196 Complement decay-accelerating factor CD55 0.008
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0079
6221 Steroid hormone receptor ERR1 ESRRA 0.0079
173 Toll-like receptor 7 TLR7 0.0079
357 Carbonic anhydrase 2 CA2 0.0078
3957 Adenosine deaminase ADA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
268 Adenosine A2b receptor ADORA2B 0.0077
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0075
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0075
558 Solute carrier family 12 member 1 SLC12A1 0.0075
1541 Metalloproteinase mmp20 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0074
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0072
164 Histamine H4 receptor HRH4 0.0071
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0071
2230 Catalase CAT 0.0071
3249 Catalase katA 0.0071
3625 Catalase katA 0.0071
4539 Catalase katA 0.0071
4941 Catalase katB 0.0071
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0071
6824 Tyrosine-protein kinase Lyn LYN 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
765 Indoleamine 2,3-dioxygenase IDO1 0.0071
6149 Solute carrier family 22 member 10 SLC22A10 0.007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
2216 Fibroblast growth factor receptor 4 FGFR4 0.007
6126 Carbonic anhydrase 7 CA7 0.007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0069
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0068
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0068
572 Integrin alpha-L ITGAL 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
6211 Tubulin epsilon chain TUBE1 0.0067
6212 Tubulin gamma-1 chain TUBG1 0.0067
6210 Tubulin delta chain TUBD1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0066
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0066
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0066
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0065
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0064
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0064
6163 Copper-transporting ATPase 2 ATP7B 0.0064
6165 Copper-transporting ATPase 1 ATP7A 0.0064
3917 Methylenetetrahydrofolate reductase MTHFR 0.0064
1820 Beta-nerve growth factor NGF 0.0064
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4773 Deoxycytidine kinase DCK 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
199 Monocarboxylate transporter 8 SLC16A2 0.0062
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0062
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0062
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0061
1291 cAMP response element-binding protein CREB1 0.0061
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
2981 Phospholipase A2, membrane associated PLA2G2A 0.006
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0059
6033 High affinity interleukin-8 receptor A CXCR1 0.0059
6168 Solute carrier family 22 member 16 SLC22A16 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
896 Glutathione S-transferase Mu 1 GSTM1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0057
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0057
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
712 Tubulin alpha chain TUB1 0.0052
1039 Histone deacetylase 9 HDAC9 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
1374 Natriuretic peptides B NPPB 0.0048
1827 Gap junction alpha-1 protein GJA1 0.0048
1908 Vascular cell adhesion protein 1 VCAM1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
1864 RET proto-oncogene RET 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0047
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0046
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0046
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
527 Prostacyclin receptor PTGIR 0.0045
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0045
400 Coagulation factor IX F9 0.0044
5461 Coagulation factor IX F9 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
2021 Thrombomodulin THBD 0.0044
130 Prostacyclin synthase PTGIS 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
76 Nitric-oxide synthase, brain NOS1 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.0041
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0041
604 Vitamin K-dependent protein Z PROZ 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
6218 Pannexin-1 PANX1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
2391 Ferrochelatase hemH 0.0038
6502 Ferrochelatase DKFZp686P18130 0.0038
1591 Ferrochelatase, mitochondrial FECH 0.0038
85 Growth hormone receptor GHR 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
422 Vitamin K-dependent protein C PROC 0.0037
1245 Vitamin K-dependent protein S PROS1 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
2207 Rhodopsin RHO 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
489 Monocarboxylate transporter 2 SLC16A7 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6493 Cytochrome c oxidase subunit 6C COX6C 0.0032
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0032
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0032
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0032
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0032
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0032
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0032
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0032
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0032
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0032
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0032
6559 Cytochrome c oxidase subunit 2 ctaC 0.0032
6669 Cytochrome c oxidase subunit 2 ctaC 0.0032
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0032
6558 Cytochrome c oxidase subunit 1 ctaD 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0032
6072 Potassium channel subfamily K member 3 KCNK3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1792 Tissue-type plasminogen activator PLAT 0.003
798 Osteocalcin BGLAP 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
2540 Choloylglycine hydrolase cbh 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6501 Fatty acid-binding protein, liver FABP1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
369 Coagulation factor VII F7 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6042 Prostaglandin reductase 2 PTGR2 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1650 Heme carrier protein 1 SLC46A1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
6859 Protein S100-A4 S100A4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
340 Apoptotic protease-activating factor 1 APAF1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6500 Phospholipase A2 PLA2G1B 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
822 Aldose reductase AKR1B1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0022
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0022
825 Arsenical pump-driving ATPase ASNA1 0.0022
3435 Arsenical pump-driving ATPase arsA 0.0022
2232 Interleukin-5 IL5 0.0022
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0021
154 AFG3-like protein 2 AFG3L2 0.0021
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0021
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0021
733 Activin receptor type 1B ACVR1B 0.0021
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0021
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0021
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0021
395 ALK tyrosine kinase receptor Not Available 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
1313 Lactoylglutathione lyase GLO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
292 Activin receptor type-1 ACVR1 0.002
849 Activated CDC42 kinase 1 TNK2 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0019
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0019
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0019
297 Adenylate cyclase type 1 ADCY1 0.0019
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
5818 Folate receptor alpha FOLR1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
740 Argininosuccinate synthase ASS1 0.0016
865 Argininosuccinate synthase ASS1 0.0016
2680 Argininosuccinate synthase argG 0.0016
3194 Argininosuccinate synthase argG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
661 ADP/ATP translocase 1 SLC25A4 0.0016
6021 Adenosine kinase ADK 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0015
6677 Myelin P2 protein PMP2 0.0015
293 Gamma-glutamyl hydrolase GGH 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3221 Cytochrome c4 cc4 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
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