DT-Web: DB00203

Identification

Name

Sildenafil

Accession Number

DB00203 (APRD00556)

Type

small molecule

Description

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

474.576

Groups

approved

Monoisotopic Weight

474.204924168

Pharmacology

Indication

For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).

Mechanism of action

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Absorption

>90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism

Protein binding

96%

Biotransformation

Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring.

Route of elimination

Sildenafil is cleared predominantly by the CYP3A (major route) and cytochrome P450 2C9 (CYP2C9, minor route) hepatic microsomal isoenzymes. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	The protease inhibitor, amprenavir, may increase the effect and toxicity of sildenafil.
Asenapine	Increased incidence of adverse effects (hypotension) due to pharmacodynamic synergism. Concomitant therapy should be avoided.
Atazanavir	Increases the effect and toxicity of sildenafil
Cimetidine	Increases the effect and toxicity of sildenafil
Ciprofloxacin	Ciprofloxacin may increase the serum level of sildenafil.
Clarithromycin	Increases the effect and toxicity of sildenafil
Conivaptan	CYP3A4 Inhibitors (Strong) such as conivaptan may increase the serum concentration of Sildenafil. When sildenanfil is used for treatment of pulmonary arterial hypertension, concurrent use with strong CYP3A4 inhibitors is not recommended. When sildenafil is used for treatment of erectile dysfunction, consider using a lower starting dose of 25 mg in patients who are also taking a strong CYP3A4 inhibitor. Due to the particularly strong effects of ritonavir, sildenafil (for erectile dysfunction) doses greater than 25 mg per 48 hours are not recommended. Of note, the interaction between CYP3A4 inhibitors and sildenafil is predicted to be greater with orally administered than with injected sildenafil.
Erythromycin	The macrolide, erythromycin, may increase the effect and toxicity of sildenafil.
Etravirine	Sildenafil (and other phosphodiesterase 5 inhibitors), when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor the efficacy of sildenafil therapy.
Fosamprenavir	The protease inhibitor, fosamprenavir, may increase the effect and toxicity of sildenafil.
Indinavir	The protease inhibitor, indinavir, may increase the effect and toxicity of sildenafil.
Isosorbide Dinitrate	Possible significant hypotension with this combination
Isosorbide Mononitrate	Possible significant hypotension with this combination
Itraconazole	Itraconazole may increase the effect and toxicity of sildenafil.
Ketoconazole	Ketoconazole may increase the effect and toxicity of sildenafil.
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect and toxicity of sildenafil.
Nitroglycerin	Possible significant hypotension with this combination
Pentaerythritol Tetranitrate	Possible significant hypotension with this combination
Telithromycin	Telithromycin may reduce clearance of Sildenafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sildenafil if Telithromycin is initiated, discontinued or dose changed.
Terazosin	Increased risk of hypotension.
Tipranavir	Tipranavir, co-administered with Ritonavir, may increase the concentration of Sildenafil. Alternate therapy should be considered.
Vigabatrin	Increased anticonvulsant effects of vigabatrin due to pharmacodynamic synergism. Monitor for adverse effects during concomitant therapy.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of sildenafil by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of sildenafil if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Not Available

cGMP-specific 3',5'-cyclic phosphodiesterase
Name	cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name	PDE5A
Pharmacological action	yes
Actions	inhibitor
References	Carson CC: Long-term use of sildenafil. Expert Opin Pharmacother. 2003 Mar;4(3):397-405. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Corbin JD, Francis SH, Webb DJ: Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology. 2002 Sep;60(2 Suppl 2):4-11. - Pubmed Kruuse C, Thomsen LL, Birk S, Olesen J: Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain. 2003 Jan;126(Pt 1):241-7. - Pubmed Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA: PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J. 2003 Feb 3;22(3):469-78. - Pubmed Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H: Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. J Biol Chem. 2006 Jul 28;281(30):21469-79. Epub 2006 May 30. - Pubmed Wang H, Ye M, Robinson H, Francis SH, Ke H: Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol Pharmacol. 2008 Jan;73(1):104-10. Epub 2007 Oct 24. - Pubmed Wang J, Re J, Wang Z: [Mode of action of sildenafil] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999 Dec;21(6):493-6. - Pubmed Zoraghi R, Francis SH, Corbin JD: Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors. Biochemistry. 2007 Nov 27;46(47):13554-63. Epub 2007 Nov 3. - Pubmed
DTHybrid score	Not Available
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Name	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene Name	PDE6G
Pharmacological action	no
Actions	inhibitor
References	Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG: Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. Epub 2006 Jun 6. - Pubmed
DTHybrid score	Not Available
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Name	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene Name	PDE6H
Pharmacological action	no
Actions	inhibitor
References	Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG: Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. Epub 2006 Jun 6. - Pubmed
DTHybrid score	Not Available

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. Epub 2008 Feb 28. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Hyland R, Roe EG, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. - Pubmed
DTHybrid score	0.942
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. Epub 2008 Feb 28. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.6018
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3994
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Hyland R, Roe EG, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. - Pubmed
DTHybrid score	0.5802
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5144
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5852
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.324
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3772

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. - Pubmed Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. - Pubmed
DTHybrid score	0.2891
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	inhibitor
References	Jedlitschky G, Burchell B, Keppler D: The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74. - Pubmed Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. - Pubmed
DTHybrid score	0.2199
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score	0.1751

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.3854
1588	Multidrug resistance protein 1	ABCB1	0.3548
4924	Cytochrome P450 2C8	CYP2C8	0.3285
6030	Cytochrome P450 2B6	CYP2B6	0.2214
5718	Cytochrome P450 2A6	CYP2A6	0.1468
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.143
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1414
5360	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	0.1321
587	Serum albumin	ALB	0.1213
20	Prostaglandin G/H synthase 1	PTGS1	0.1132
862	Multidrug resistance-associated protein 1	ABCC1	0.1128
1729	Solute carrier family 22 member 6	SLC22A6	0.1064
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0935
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0928
6142	Solute carrier family 22 member 8	SLC22A8	0.0921
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0913
1898	Cytochrome P450 1B1	CYP1B1	0.0855
492	Histamine H1 receptor	HRH1	0.081
776	Bile salt export pump	ABCB11	0.0755
6145	Solute carrier family 22 member 1	SLC22A1	0.0749
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0737
6106	Cytochrome P450 2C18	CYP2C18	0.0728
6144	Solute carrier family 22 member 2	SLC22A2	0.0727
824	Sodium-dependent serotonin transporter	SLC6A4	0.0712
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.071
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0701
290	Prostaglandin G/H synthase 2	PTGS2	0.07
6143	Solute carrier family 22 member 7	SLC22A7	0.0697
2256	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	0.0667
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0638
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0614
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0589
3811	Cytochrome P450 19A1	CYP19A1	0.0586
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.056
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0554
831	D(2) dopamine receptor	DRD2	0.0536
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0532
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0515
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0513
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0507
556	Alpha-1A adrenergic receptor	ADRA1A	0.0503
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0503
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0492
6147	Solute carrier family 22 member 3	SLC22A3	0.0484
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0479
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0473
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0472
847	Mu-type opioid receptor	OPRM1	0.0471
6031	Cytochrome P450 3A43	CYP3A43	0.0461
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0455
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0444
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0438
766	Beta-2 adrenergic receptor	ADRB2	0.0437
901	Glutathione S-transferase Mu 4	GSTM4	0.043
6137	Multidrug resistance-associated protein 6	ABCC6	0.042
468	Cytochrome P450 4A11	CYP4A11	0.0408
1024	Solute carrier family 22 member 11	SLC22A11	0.0402
260	Cytochrome P450 51	ERG11	0.0387
761	Cytochrome P450 51	ERG11	0.0387
3163	Cytochrome P450 51	cyp51	0.0387
318	Alpha-2A adrenergic receptor	ADRA2A	0.0382
118	Organic cation/carnitine transporter 2	SLC22A5	0.038
5626	Nucleoside diphosphate kinase B	NME2	0.0379
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0375
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0375
713	Sodium-dependent dopamine transporter	SLC6A3	0.0373
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0367
136	Estrogen receptor	ESR1	0.0366
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0362
590	5-hydroxytryptamine 2C receptor	HTR2C	0.036
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0357
193	Beta-1 adrenergic receptor	ADRB1	0.0356
871	Glucocorticoid receptor	NR3C1	0.0356
3957	Adenosine deaminase	ADA	0.0354
731	HIV-1 protease	HIV-1 protease	0.035
817	DNA topoisomerase 2-alpha	TOP2A	0.0346
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0346
23	D(1A) dopamine receptor	DRD1	0.0343
467	Delta-type opioid receptor	OPRD1	0.0339
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0338
16	Adenosine A1 receptor	ADORA1	0.0338
632	Alpha-1B adrenergic receptor	ADRA1B	0.0332
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.033
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.033
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0329
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0328
1178	Adenosine A2a receptor	ADORA2A	0.0328
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0316
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0315
1830	5'-nucleotidase	NT5E	0.0312
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0311
696	Kappa-type opioid receptor	OPRK1	0.031
3947	Xanthine dehydrogenase/oxidase	XDH	0.031
6141	Sodium/bile acid cotransporter	SLC10A1	0.0308
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0307
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0306
5294	Nucleoside diphosphate kinase A	NME1	0.03
638	D(3) dopamine receptor	DRD3	0.0297
24	Thymidylate synthase	TMP1	0.0285
359	Thymidylate synthase	TYMS	0.0285
2626	Thymidylate synthase	thyA	0.0285
2729	Thymidylate synthase	thyA	0.0285
5352	Thymidylate synthase	THYA	0.0285
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0281
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.028
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0271
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0271
3941	Amine oxidase [flavin-containing] A	MAOA	0.0271
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0271
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0271
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.027
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0268
465	Calmodulin	CALM1	0.0266
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0263
833	Organic cation/carnitine transporter 1	SLC22A4	0.0262
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0261
4773	Deoxycytidine kinase	DCK	0.0251
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.025
6020	Aldehyde oxidase	AOX1	0.0249
6182	Cytochrome P450 2J2	CYP2J2	0.0239
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0238
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0237
6171	Solute carrier family 28 member 3	SLC28A3	0.0236
6220	Aryl hydrocarbon receptor	AHR	0.0235
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0234
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0233
342	P protein [Includes: DNA-directed DNA polymerase	P	0.023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.023
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0229
3611	Cytidine deaminase	cdd	0.0228
3707	Cytidine deaminase	cdd	0.0228
4211	Cytidine deaminase	CDA	0.0228
777	Tumor necrosis factor	TNF	0.0223
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0223
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0214
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0213
4604	Liver carboxylesterase 1	CES1	0.0213
29	Tubulin beta-1 chain	TUBB1	0.0209
6085	Fatty acid-binding protein, intestinal	FABP2	0.0208
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0208
3939	Amine oxidase [flavin-containing] B	MAOB	0.0208
614	Progesterone receptor	PGR	0.0207
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0207
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0203
122	P2Y purinoceptor 12	P2RY12	0.0203
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0202
629	Alpha-2B adrenergic receptor	ADRA2B	0.0201
378	Alpha-2C adrenergic receptor	ADRA2C	0.02
789	Alpha-1D adrenergic receptor	ADRA1D	0.0199
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0199
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0192
738	Monocarboxylate transporter 1	SLC16A1	0.0192
432	D(4) dopamine receptor	DRD4	0.0192
3685	Catabolite gene activator	crp	0.0191
4655	Adenylate cyclase	cyaC	0.0191
4759	Adenylate cyclase	cyaB2	0.0191
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0189
161	Tubulin beta chain	TUBB	0.0187
312	Tubulin beta chain	TUB2	0.0187
6014	Cytochrome P450 2A13	CYP2A13	0.0185
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0185
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0184
811	Translocator protein	TSPO	0.0184
504	Mast/stem cell growth factor receptor	KIT	0.0183
4120	NADPH--cytochrome P450 reductase	POR	0.0182
891	Dihydropteroate synthase	folP	0.0182
5359	Dihydropteroate synthase	folP	0.0182
7175	Dihydropteroate synthase	sulI	0.0182
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0182
273	Apoptosis regulator Bcl-2	BCL2	0.018
146	Androgen receptor	AR	0.0179
5923	Microtubule-associated protein tau	MAPT	0.0179
5924	Microtubule-associated protein 4	MAP4	0.0179
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0175
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0174
1852	Microtubule-associated protein 2	MAP2	0.0174
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0174
1010	Cytochrome P450 51A1	CYP51A1	0.0173
1405	Thiopurine S-methyltransferase	TPMT	0.0172
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0171
756	Sex hormone-binding globulin	SHBG	0.017
725	5-hydroxytryptamine 1D receptor	HTR1D	0.017
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0168
737	Mineralocorticoid receptor	NR3C2	0.0167
844	Epidermal growth factor receptor	EGFR	0.0167
1757	Myeloperoxidase	MPO	0.0166
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0166
3923	Cholinesterase	BCHE	0.0164
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0163
4760	Mll3241 protein	mll3241	0.0163
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0161
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.016
4122	Histone deacetylase 2	HDAC2	0.016
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.016
26	Vascular endothelial growth factor receptor 3	FLT4	0.0159
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0159
407	Vascular endothelial growth factor receptor 2	KDR	0.0157
232	Corticosteroid-binding globulin	SERPINA6	0.0156
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0153
908	Glutathione S-transferase theta-1	GSTT1	0.0153
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0153
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0153
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0153
32	Vascular endothelial growth factor receptor 1	FLT1	0.0152
94	5-hydroxytryptamine 4 receptor	HTR4	0.0152
2539	Tubulin alpha-1 chain	TUBA4A	0.0152
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.015
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.015
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.015
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.015
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0148
33	Cystine/glutamate transporter	SLC7A11	0.0148
6102	Arylamine N-acetyltransferase 2	NAT2	0.0147
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0147
613	Atrial natriuretic peptide receptor A	NPR1	0.0146
904	Glutathione S-transferase P	GSTP1	0.0146
4192	DNA topoisomerase 2-beta	TOP2B	0.0144
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0144
380	Cytochrome P450 17A1	CYP17A1	0.0143
2516	GMP reductase 1	GMPR	0.0141
2361	Response regulator pleD	pleD	0.0141
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0141
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.014
716	5-hydroxytryptamine 7 receptor	HTR7	0.0138
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0137
4106	Guanylate kinase	GUK1	0.0135
4516	Guanylate kinase	gmk	0.0135
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0134
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0134
3932	Glutathione S-transferase A2	GSTA2	0.0134
705	Glutamate receptor 1	GRIA1	0.0134
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0134
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0133
6167	Organic solute transporter subunit beta	OSTB	0.0133
6166	Organic solute transporter subunit alpha	OSTA	0.0133
702	UMP-CMP kinase	CMPK1	0.0131
295	Carbonic anhydrase 1	CA1	0.0128
482	Glycine receptor subunit alpha-1	GLRA1	0.0128
952	Dipeptidyl peptidase 4	DPP4	0.0127
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0127
124	Histamine H2 receptor	HRH2	0.0127
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
70	Type-1 angiotensin II receptor	AGTR1	0.0126
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0126
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0126
592	Carbonic anhydrase 4	CA4	0.0125
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0124
4217	Telomerase reverse transcriptase	TERT	0.0123
125	DNA polymerase beta	POLB	0.0123
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0121
365	Dihydrofolate reductase	DHFR	0.012
2381	Dihydrofolate reductase	DFR1	0.012
2833	Dihydrofolate reductase	Not Available	0.012
2931	Dihydrofolate reductase	folA	0.012
3544	Dihydrofolate reductase	folA	0.012
3682	Dihydrofolate reductase	folA	0.012
6642	Dihydrofolate reductase	folA	0.012
6756	Dihydrofolate reductase	dfrA	0.012
165	FL cytokine receptor	FLT3	0.0119
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0119
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0118
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0117
1517	Beta-3 adrenergic receptor	ADRB3	0.0116
48	Pyridoxal kinase	PDXK	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
293	Gamma-glutamyl hydrolase	GGH	0.0114
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0114
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0113
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0113
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0113
163	D(1B) dopamine receptor	DRD5	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
869	Estrogen receptor beta	ESR2	0.0112
1650	Heme carrier protein 1	SLC46A1	0.0112
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0112
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0112
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0111
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.011
268	Adenosine A2b receptor	ADORA2B	0.011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.011
4226	Uridine phosphorylase 2	UPP2	0.011
818	50S ribosomal protein L10	rplJ	0.0109
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0108
3300	Xanthine phosphoribosyltransferase	xpt	0.0107
3681	Xanthine phosphoribosyltransferase	gpt	0.0107
1656	CYP2B protein	CYP2B	0.0107
427	Substance-P receptor	TACR1	0.0107
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0106
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0106
373	Transthyretin	TTR	0.0106
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0104
6146	High affinity copper uptake protein 1	SLC31A1	0.0103
790	DNA polymerase subunit alpha B	POLA2	0.0103
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0101
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0101
4203	Histamine N-methyltransferase	HNMT	0.01
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.01
3810	Catechol O-methyltransferase	COMT	0.01
2449	Tubulin alpha-3 chain	TUBA1A	0.01
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0099
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0099
2112	Toll-like receptor 9	TLR9	0.0098
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0098
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0098
2499	Tubulin beta-2C chain	TUBB2C	0.0098
474	Acetylcholinesterase	ACHE	0.0098
4225	Uridine phosphorylase 1	UPP1	0.0097
1648	Elastin	ELN	0.0096
723	Cytosolic phospholipase A2	PLA2G4A	0.0096
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0096
49	Endothelin B receptor	EDNRB	0.0096
814	Ryanodine receptor 1	RYR1	0.0096
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0095
823	Fibroblast growth factor receptor 2	FGFR2	0.0095
6126	Carbonic anhydrase 7	CA7	0.0094
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0094
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0094
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0094
413	Amidophosphoribosyltransferase	PPAT	0.0093
2515	Amidophosphoribosyltransferase	purF	0.0093
3714	Amidophosphoribosyltransferase	purF	0.0093
6149	Solute carrier family 22 member 10	SLC22A10	0.0093
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0093
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0093
357	Carbonic anhydrase 2	CA2	0.0093
2320	Thymidine kinase, cytosolic	TK1	0.0092
284	DNA-directed RNA polymerase beta chain	rpoB	0.0092
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0092
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0091
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0091
3639	Thymidine phosphorylase	deoA	0.009
3936	Thymidine phosphorylase	TYMP	0.009
477	DNA topoisomerase 4 subunit A	parC	0.009
886	DNA topoisomerase 4 subunit A	parC	0.009
6226	DNA topoisomerase 4 subunit A	parC	0.009
578	Endothelin-1 receptor	EDNRA	0.009
153	Dopamine beta-hydroxylase	DBH	0.009
404	DNA gyrase subunit A	gyrA	0.0089
6224	DNA gyrase subunit A	gyrA	0.0089
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0089
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0087
896	Glutathione S-transferase Mu 1	GSTM1	0.0086
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0086
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0086
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0086
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0085
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0084
571	Melatonin receptor type 1A	MTNR1A	0.0084
362	Melatonin receptor type 1B	MTNR1B	0.0084
183	Vascular endothelial growth factor A	VEGFA	0.0084
84	Nuclear receptor 0B1	NR0B1	0.0084
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0084
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0083
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
68	Cannabinoid receptor 1	CNR1	0.0083
768	FK506-binding protein 1A	FKBP1A	0.0083
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0082
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0082
4311	tRNA	TRDMT1	0.0082
4325	tRNA	trmD	0.0082
4328	tRNA	trmD	0.0082
6218	Pannexin-1	PANX1	0.0081
1141	Sialidase-1	NEU1	0.008
64	Neuraminidase	NA	0.008
641	Neuraminidase	NA	0.008
2676	Neuraminidase	NA	0.008
3026	Neuraminidase	NA	0.008
3519	Neuraminidase	NA	0.008
6007	Neuraminidase	NA	0.008
6043	Putative G-protein coupled receptor 44	GPR44	0.008
976	Platelet glycoprotein IX	GP9	0.008
921	Glutamate receptor 2	GRIA2	0.008
1050	Bile salt sulfotransferase	SULT2A1	0.008
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.008
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0079
1192	Sulfotransferase 1A1	SULT1A1	0.0079
275	Arachidonate 5-lipoxygenase	ALOX5	0.0078
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0078
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0077
820	Glycine receptor subunit alpha-2	GLRA2	0.0077
131	Synaptic vesicular amine transporter	SLC18A2	0.0076
469	Annexin A1	ANXA1	0.0075
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0075
54	Prothrombin	F2	0.0074
251	Alcohol dehydrogenase 1A	ADH1A	0.0073
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0073
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0072
3587	Gastrotropin	FABP6	0.0072
444	Alcohol dehydrogenase 1B	ADH1B	0.0072
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0072
6766	O-GlcNAcase BT_4395	BT_4395	0.0071
1483	Membrane copper amine oxidase	AOC3	0.0071
4228	Keratin, type II cytoskeletal 7	KRT7	0.007
174	Sigma 1-type opioid receptor	SIGMAR1	0.007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0069
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0069
718	Folate receptor gamma	FOLR3	0.0069
299	Folate receptor beta	FOLR2	0.0069
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0069
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0068
4237	50S ribosomal protein L22	rplV	0.0068
7	Nitric oxide synthase, inducible	NOS2	0.0068
3601	Dihydropteroate synthase 1	folP1	0.0067
3807	Dihydropteroate synthase 1	folP1	0.0067
3808	Dihydropteroate synthase 2	folP2	0.0067
6165	Copper-transporting ATPase 1	ATP7A	0.0067
6163	Copper-transporting ATPase 2	ATP7B	0.0067
239	Coagulation factor X	F10	0.0067
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0067
3809	Estrogen-related receptor gamma	ESRRG	0.0067
319	Opioid receptor, sigma 1	OPRS1	0.0066
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0066
517	Alcohol dehydrogenase 1C	ADH1C	0.0066
856	Vitamin D3 receptor	VDR	0.0066
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0066
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0066
1196	Complement decay-accelerating factor	CD55	0.0065
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0064
1275	Estrogen sulfotransferase	SULT1E1	0.0064
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0063
1618	High affinity nerve growth factor receptor	NTRK1	0.0063
133	Dihydropterate synthase	sulI	0.0063
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0063
5482	Sialidase-2	NEU2	0.0062
5818	Folate receptor alpha	FOLR1	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0062
518	Peroxidase/catalase T	katG	0.0061
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0061
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0061
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0061
1629	Transcription factor AP-1	JUN	0.0061
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
6033	High affinity interleukin-8 receptor A	CXCR1	0.0059
581	Cytochrome P450 2R1	CYP2R1	0.0059
780	Retinoic acid receptor RXR-gamma	RXRG	0.0058
106	Cannabinoid receptor 2	CNR2	0.0057
563	Thyroid peroxidase	TPO	0.0056
2808	Chloramphenicol acetyltransferase 3	cat3	0.0056
5300	Antigen peptide transporter 1	TAP1	0.0056
634	Squalene monooxygenase	SQLE	0.0056
7196	Squalene monooxygenase	ERG1	0.0056
3913	Glutamic acid decarboxylase	GAD65	0.0055
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0055
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0055
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0055
6506	Stathmin-4	STMN4	0.0055
5934	Cytochrome P450 26A1	CYP26A1	0.0054
6432	Transporter	snf	0.0054
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0054
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0054
4238	50S ribosomal protein L4	rplD	0.0054
5578	50S ribosomal protein L4	rplD	0.0054
6173	50S ribosomal protein L4	rplD	0.0054
6219	50S ribosomal protein L4	rplD	0.0054
88	Retinoic acid receptor RXR-beta	RXRB	0.0053
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0052
2417	Chloramphenicol acetyltransferase	cat	0.0052
3278	Chloramphenicol acetyltransferase	cat	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
2810	Dr hemagglutinin structural subunit	draA	0.0051
489	Monocarboxylate transporter 2	SLC16A7	0.0051
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.005
3937	Fatty-acid amide hydrolase	FAAH	0.005
1630	Integrin beta-2	ITGB2	0.005
569	Retinal dehydrogenase 2	ALDH1A2	0.005
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0049
3404	Exotoxin A	eta	0.0049
173	Toll-like receptor 7	TLR7	0.0049
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0049
1313	Lactoylglutathione lyase	GLO1	0.0048
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0048
1198	Serum paraoxonase/arylesterase 1	PON1	0.0047
6223	Penicillin-binding protein 1C	pbpC	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
1374	Natriuretic peptides B	NPPB	0.0047
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0047
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0047
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0047
1827	Gap junction alpha-1 protein	GJA1	0.0047
1908	Vascular cell adhesion protein 1	VCAM1	0.0047
611	Retinal dehydrogenase 1	ALDH1A1	0.0047
3904	Alanine aminotransferase 2	GPT2	0.0046
735	Alanine aminotransferase 1	GPT	0.0046
1253	Interferon gamma	IFNG	0.0046
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1714	Mitogen-activated protein kinase 3	MAPK3	0.0046
3086	Plasmepsin-2	Not Available	0.0046
6174	50S ribosomal protein L32	rpmF	0.0046
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0046
6168	Solute carrier family 22 member 16	SLC22A16	0.0046
1992	Vitamin D-binding protein	GC	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
267	Plasminogen activator inhibitor 1	SERPINE1	0.0045
65	Matrix metalloproteinase-9	Not Available	0.0044
2230	Catalase	CAT	0.0044
3249	Catalase	katA	0.0044
3625	Catalase	katA	0.0044
4539	Catalase	katA	0.0044
4941	Catalase	katB	0.0044
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0044
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0044
4041	Microsomal glutathione S-transferase 2	MGST2	0.0044
719	Retinoic acid receptor responder protein 1	RARRES1	0.0044
770	Retinoic acid-induced protein 3	GPRC5A	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
164	Histamine H4 receptor	HRH4	0.0044
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
4103	Proteasome subunit beta type 2	PSMB2	0.0042
4102	Proteasome subunit beta type 5	PSMB5	0.0042
4101	Proteasome subunit beta type 1	PSMB1	0.0042
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0041
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0041
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0041
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0041
6044	Serum paraoxonase/lactonase 3	PON3	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
411	Glycine N-methyltransferase	GNMT	0.004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.004
4034	Glutaredoxin-1	GLRX	0.004
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.004
4037	Hypothetical protein	GPX1	0.004
4297	Hypothetical protein	SP_1951	0.004
4521	Hypothetical protein	BC_2969	0.004
4540	Hypothetical protein	TM_1070	0.004
4555	Hypothetical protein	MT1739	0.004
4569	Hypothetical protein	mshD	0.004
4578	Hypothetical protein	PA3270	0.004
4747	Hypothetical protein	PA3967	0.004
5177	Hypothetical protein	TM_0096	0.004
5194	Hypothetical protein	PA1204	0.004
5240	Hypothetical protein	Rv2991	0.004
5370	Hypothetical protein	TM_1158	0.004
5710	Hypothetical protein	Tb927.5.1360	0.004
1928	Leukotriene C4 synthase	LTC4S	0.004
4029	Microsomal glutathione S-transferase 3	MGST3	0.004
4032	Microsomal glutathione S-transferase 1	MGST1	0.004
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.004
4035	Glutathione S-transferase Mu 5	GSTM5	0.004
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.004
4040	Glutathione peroxidase 7	GPX7	0.004
910	Epididymal secretory glutathione peroxidase	GPX5	0.004
4036	Glutathione peroxidase 6	GPX6	0.004
903	Glutathione S-transferase A5	GSTA5	0.004
911	Glutathione peroxidase 3	GPX3	0.004
906	Glutathione peroxidase 1	GPX1	0.004
900	Glutathione S-transferase A4	GSTA4	0.004
4038	Glutathione peroxidase 4	GPX4	0.004
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.004
4042	Glutathione transferase omega-2	GSTO2	0.004
907	Glutathione peroxidase 2	GPX2	0.004
4033	S-formylglutathione hydrolase	ESD	0.004
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.004
6221	Steroid hormone receptor ERR1	ESRRA	0.004
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.004
751	Potassium channel subfamily K member 6	KCNK6	0.004
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0039
291	Nitric-oxide synthase, endothelial	NOS3	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2021	Thrombomodulin	THBD	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0038
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0038
2236	Casein kinase II subunit alpha	CSNK2A1	0.0038
85	Growth hormone receptor	GHR	0.0038
572	Integrin alpha-L	ITGAL	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
1864	RET proto-oncogene	RET	0.0036
172	Potassium channel subfamily K member 1	KCNK1	0.0036
936	Ephrin type-A receptor 2	EPHA2	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6131	Carbonic anhydrase 14	CA14	0.0036
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0036
897	Glutathione S-transferase kappa 1	GSTK1	0.0035
6048	Troponin C, skeletal muscle	TNNC2	0.0035
898	Glutathione S-transferase A3	GSTA3	0.0035
3830	Calreticulin	CALR	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0035
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0035
909	Maleylacetoacetate isomerase	GSTZ1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
645	Penicillin-binding protein 1A	mrcA	0.0035
5805	Penicillin-binding protein 1A	ponA	0.0035
6185	Penicillin-binding protein 1A	mrcA	0.0035
6799	Penicillin-binding protein 1A	pbpA	0.0035
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
899	Glutathione S-transferase Mu 3	GSTM3	0.0034
905	Glutathione transferase omega-1	GSTO1	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
4031	Glutathione S-transferase A1	GSTA1	0.0034
558	Solute carrier family 12 member 1	SLC12A1	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0033
6034	Hydroxyindole O-methyltransferase	ASMT	0.0033
6035	Nuclear receptor ROR-beta	RORB	0.0033
6036	Eosinophil peroxidase	EPX	0.0033
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
2165	Glutathione S-transferase Mu 2	GSTM2	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
207	Glutathione synthetase	GSS	0.0031
5269	Glutathione synthetase	gshB	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.003
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.003
1063	Signal transducer and activator of transcription 5B	STAT5B	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
115	Penicillin-binding protein 2	mrdA	0.003
6069	Penicillin-binding protein 2	mrdA	0.003
6118	Penicillin-binding protein 2	penA	0.003
6187	Penicillin-binding protein 2	pbpA	0.003
6686	Penicillin-binding protein 2	pbp2	0.003
6939	Penicillin-binding protein 2	mrdA	0.003
7163	Penicillin-binding protein 2	pbpA	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.003
76	Nitric-oxide synthase, brain	NOS1	0.003
400	Coagulation factor IX	F9	0.003
5461	Coagulation factor IX	F9	0.003
822	Aldose reductase	AKR1B1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4992	Cytochrome c peroxidase	Not Available	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
765	Indoleamine 2,3-dioxygenase	IDO1	0.0029
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1	Peptidoglycan synthetase ftsI	ftsI	0.0028
4155	Peptidoglycan synthetase ftsI	ftsI	0.0028
6042	Prostaglandin reductase 2	PTGR2	0.0028
162	Retinoic acid receptor gamma-1	RARG	0.0028
2298	Cytochrome P450-cam	camC	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
5590	N utilization substance protein B homolog	nusB	0.0028
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0028
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0028
5591	Complement component C8 gamma chain	C8G	0.0028
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0028
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0028
5587	Iron(III)-binding periplasmic protein	fbpA	0.0028
2838	Ribose-5-phosphate isomerase A	rpiA	0.0028
2952	Ribose-5-phosphate isomerase A	rpiA	0.0028
5595	Ribose-5-phosphate isomerase A	rpiA	0.0028
4695	UPF0124 protein yfiH	yfiH	0.0028
5060	Intron-associated endonuclease 1	ITEVIR	0.0028
5593	Transferase	Not Available	0.0028
5581	Beta-fructosidase	bfrA	0.0028
5588	Cell division protein FtsY	TM_0570	0.0028
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0028
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0028
5600	Pyruvate decarboxylase	pdc	0.0028
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0028
4375	Glutamine synthetase 1	glnA1	0.0028
5575	Short tail fiber protein	12	0.0028
5574	Invasin	YPTB1668	0.0028
5580	Hexon protein	PII	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0027
604	Vitamin K-dependent protein Z	PROZ	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0027
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0026
1792	Tissue-type plasminogen activator	PLAT	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
714	Glutathione reductase, mitochondrial	GSR	0.0025
422	Vitamin K-dependent protein C	PROC	0.0025
1245	Vitamin K-dependent protein S	PROS1	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
3007	Carbonic anhydrase 12	CA12	0.0025
3132	Tryptophan synthase alpha chain	trpA	0.0025
6568	Tryptophan synthase alpha chain	trpA	0.0025
4205	Carbonic anhydrase 9	CA9	0.0025
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0024
3729	Citrate synthase	gltA	0.0024
4575	Citrate synthase	cit	0.0024
4580	Citrate synthase	gltA	0.0024
5328	Prostaglandin F synthase	Tb11.02.2310	0.0024
5006	RNASE4 protein	RNASE4	0.0024
2555	Pol polyprotein	pol	0.0024
3242	Pol polyprotein	gag-pol	0.0024
3471	Pol polyprotein	gag-pro-pol	0.0024
5256	Pol polyprotein	pol	0.0024
6469	Pol polyprotein	gag-pol	0.0024
6565	Pol polyprotein	Not Available	0.0024
4533	Glyoxalase family protein	BC_1747	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0024
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0024
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0024
358	Cystathionine beta-synthase	CBS	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
2521	Cell division protein ftsZ	ftsZ	0.0023
3301	Cell division protein ftsZ	ftsZ	0.0023
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0023
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0022
2603	Beta-lactamase II	blm	0.0022
2149	Angiogenin	ANG	0.0022
3583	6-phosphogluconolactonase	pgl	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
857	Malate dehydrogenase, mitochondrial	MDH2	0.0021
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0021
3486	Fumarate hydratase class II	fumC	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
2286	Isocitrate dehydrogenase [NADP]	icd	0.0021
2302	Isocitrate dehydrogenase [NADP]	icd	0.0021
2771	Isocitrate dehydrogenase [NADP]	icd	0.0021
2942	Sialidase	nanH	0.0021
3546	Sialidase	nedA	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0021
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.002
332	Beta-lactamase	blaZ	0.002
2478	Beta-lactamase	ampC	0.002
2613	Beta-lactamase	ampC	0.002
2635	Beta-lactamase	ampC	0.002
2700	Beta-lactamase	penP	0.002
5445	Beta-lactamase	blaB	0.002
6019	Beta-lactamase	SHV-7	0.002
6701	Beta-lactamase	cphA	0.002
2697	Uridine-cytidine kinase 2	UCK2	0.002
2452	Tryptophanyl-tRNA synthetase	trpS	0.002
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.002
798	Osteocalcin	BGLAP	0.002
1360	Sphingomyelin phosphodiesterase	SMPD1	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
2408	Tyrosine-protein kinase SYK	SYK	0.0019
1039	Histone deacetylase 9	HDAC9	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
5579	Carboxypeptidase B	CPB1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
3384	Macrophage migration inhibitory factor	MIF	0.0018
369	Coagulation factor VII	F7	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
128	Adenine phosphoribosyltransferase	APRT	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
3221	Cytochrome c4	cc4	0.0015
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0015
5682	Ribonuclease pancreatic	RNASE1	0.0014
2207	Rhodopsin	RHO	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6501	Fatty acid-binding protein, liver	FABP1	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
345	Plasma retinol-binding protein	RBP4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
2132	Protein S100-B	S100B	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6459	Glycodelin	PAEP	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1507	Cytochrome c	CYCS	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00203 - Sildenafil

Targets

Enzymes

Transporters

Predictions