DT-Web

DB00701 - Amprenavir


Identification
Name Amprenavir
Accession Number DB00701 (APRD00605)
Type small molecule
Description Amprenavir is a protease inhibitor used to treat HIV infection.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 505.627
Groups approved
Monoisotopic Weight 505.224656557
Pharmacology
Indication For the treatment of HIV-1 infection in combination with other antiretroviral agents.
Mechanism of action Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Absorption Rapidly absorbed after oral administration in HIV-1-infected patients with a time to peak concentration (Tmax) typically between 1 and 2 hours after a single oral dose. The absolute oral bioavailability of amprenavir in humans has not been established.
Protein binding Very high (90%). Amprenavir has the highest affinity for alpha(1)-acid glycoprotein.
Biotransformation Hepatic. Amprenavir is metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system. The 2 major metabolites result from oxidation of the tetrahydrofuran and aniline moieties. Glucuronide conjugates of oxidized metabolites have been identified as minor metabolites in urine and feces.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Abacavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Amprenavir. The antiviral response should be closely monitored.
Acenocoumarol Amprenavir may increase the anticoagulant effect of acenocoumarol by increasing its serum concentration.
Alprazolam Amprenavir may increase the effect and toxicity of the benzodiazepine, alprazolam.
Aluminium The antiacid decreases the absorption of amprenavir
Amiodarone The protease inhibitor, amprenavir, may increase the effect and toxicity of amiodarone.
Anisindione Amprenavir may increase the anticoagulant effect of anisindione by increasing its serum concentration.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atorvastatin Amprenavir may increase the serum concentration of atorvastatin by decreasing its metabolism. Concomitant therapy is contraindicated.
Bepridil Amprenavir may increase the effect and toxicity of bepridil.
Bismuth Subsalicylate The antiacid decreases the absorption of amprenavir
Calcium The antiacid decreases the absorption of amprenavir
Cisapride Amprenavir may increase the effect and toxicity of cisapride.
Clorazepate Amprenavir may increase the effect and toxicity of the benzodiazepine, clorazepate.
Cyclosporine The protease inhibitor, amprenavir, may increase the effect of cyclosporine.
Delavirdine Decreased levels of delavirdine with increased levels of amprenavir
Diazepam Amprenavir may increase the effect and toxicity of the benzodiazepine, diazepam.
Dicumarol Amprenavir may increase the anticoagulant effect of dicumarol by increasing its serum concentration.
Dihydroergotamine Amprenavir may increase the serum concentration of dihydroergotamine. Concomitant therapy is contraindicated.
Dihydroxyaluminium The antiacid decreases the absorption of amprenavir
Disulfiram Increased irsk of side effects (oral solution)
Ergotamine Amprenavir may increase the effect and toxicity of ergotamine.
Ethinyl Estradiol Ritonavir could decrease the contraceptive efficacy
Fentanyl The protease inhibitor, amprenavir, may increase the effect and toxicity of fentanyl.
Flurazepam Amprenavir may increase the effect and toxicity of the benzodiazepine, flurazepam.
Fusidic Acid The protease inhibitor, amprenavir, may increase the effect and toxicity of fusidic acid.
Lovastatin Amprenavir may increase the serum concentration of the lovastatin. Concomitant therapy is contraindicated.
Magnesium The antiacid decreases the absorption of amprenavir
Magnesium oxide The antiacid decreases the absorption of amprenavir
Mestranol Ritonavir could decrease the contraceptive efficacy
Methadone The protease inhibitor, amprenavir, may decrease the effect of methadone.
Metronidazole Increased risk of side effects (oral solution)
Midazolam Amprenavir may increase the effect and toxicity of the benzodiazepine, midazolam.
Pimozide Amprenavir may increase the effect and toxicity of pimozide.
Ranolazine Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentratin of ranolazine by inhibiting its metabolism. Concomitant therapy is contraindicated.
Rifabutin Amprenavir may increase the effect and toxicity of rifabutin.
Rifampin In presence of rifampin anticipate decrease of amprenavir efficiency
Sildenafil The protease inhibitor, amprenavir, may increase the effect and toxicity of sildenafil.
Simvastatin Amprenavir may increase the effect and toxicity of simvastatin. Concomitant therapy is contraindicated.
St. John's Wort St. John's Wort decreases the effect of indinavir
Tacrolimus The protease inhibitor, Amprenavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Amprenavir therapy is initiated, discontinued or altered.
Tadalafil Amprenavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Amprenavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin Amprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Amprenavir is initiated, discontinued, or dose changed.
Telithromycin Co-administration may result in altered plasma concentrations of Amprenavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus Amprenavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Amprenavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Amprenavir is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tiagabine The strong CYP3A4 inhibitor, Amprenavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Amprenavir is initiated, discontinued or dose changed.
Tolterodine Amprenavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Amprenavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The protease inhibitor, Amprenavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Amprenavir is initiated, discontinued or dose changed.
Triazolam Amprenavir may increase the effect and toxicity of the benzodiazepine, triazolam.
Trimipramine The strong CYP3A4 inhibitor, Amprenavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Amprenavir is initiated, discontinued or dose changed.
Vardenafil Amprenavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Amprenavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Amprenavir is initiated, discontinued, or dose changed.
Verapamil Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Amprenavir is initiated, discontinued or dose changed.
Vinblastine Amprenavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Amprenavir is initiated, discontinued or dose changed.
Vincristine Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Amprenavir is initiated, discontinued or dose changed.
Vinorelbine Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Amprenavir is initiated, discontinued or dose changed.
Vitamin E Increased serum levels of vitamin E
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of amprenavir by decreasing its metabolism. The serum concentration of voriconazole may be increased by amprenavir. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Warfarin Amprenavir may increase the anticoagulant effect of warfarin by increasing its serum concentration.
Zolpidem Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if amprenavir is initiated, discontinued or dose changed.
Zonisamide Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if amprenavir is initiated, discontinued or dose changed.
Zopiclone Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if amprenavir is initiated, discontinued or dose changed.
Food Interactions
  • Avoid alcohol, especially with the oral solution since it contains propylene glycol which competes with alcohol for alcohol dehydrogenase metabolism.
  • Take with or without food, however avoid lipid-rich meals.
  • Vitamin E increases amprenavir bioavailability.

Targets


HIV-1 protease
Name HIV-1 protease
Gene Name HIV-1 protease
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed
  • Dierynck I, De Wit M, Gustin E, Keuleers I, Vandersmissen J, Hallenberger S, Hertogs K: Binding kinetics of darunavir to HIV-1 protease explain the potent antiviral activity and high genetic barrier. J Virol. 2007 Oct 10;. - Pubmed
  • Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Next Generation Protease Inhibitor of Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother. 2007 Jul 16;. - Pubmed
DTHybrid score 0.3471

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8944
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3876
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5362
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4357
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6115
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5994
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4226

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor,inducer
References
  • Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.5485
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. - Pubmed
DTHybrid score 0.2493

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3342
6107 Cytochrome P450 3A7 CYP3A7 0.2785
6013 Cytochrome P450 2E1 CYP2E1 0.1906
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1652
6024 Cytochrome P450 1A1 CYP1A1 0.1357
587 Serum albumin ALB 0.1355
5718 Cytochrome P450 2A6 CYP2A6 0.1295
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1289
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1158
20 Prostaglandin G/H synthase 1 PTGS1 0.1096
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1085
492 Histamine H1 receptor HRH1 0.087
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0864
6106 Cytochrome P450 2C18 CYP2C18 0.0839
824 Sodium-dependent serotonin transporter SLC6A4 0.0789
6145 Solute carrier family 22 member 1 SLC22A1 0.0771
1729 Solute carrier family 22 member 6 SLC22A6 0.0682
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0653
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0651
776 Bile salt export pump ABCB11 0.0637
1898 Cytochrome P450 1B1 CYP1B1 0.0582
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0569
502 5-hydroxytryptamine 2A receptor HTR2A 0.0568
831 D(2) dopamine receptor DRD2 0.0566
6144 Solute carrier family 22 member 2 SLC22A2 0.0561
556 Alpha-1A adrenergic receptor ADRA1A 0.0559
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0556
290 Prostaglandin G/H synthase 2 PTGS2 0.0552
3811 Cytochrome P450 19A1 CYP19A1 0.0536
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0506
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0487
817 DNA topoisomerase 2-alpha TOP2A 0.0474
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0472
847 Mu-type opioid receptor OPRM1 0.0461
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.046
2164 Multidrug resistance-associated protein 4 ABCC4 0.0459
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0458
118 Organic cation/carnitine transporter 2 SLC22A5 0.0457
6142 Solute carrier family 22 member 8 SLC22A8 0.0452
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0439
871 Glucocorticoid receptor NR3C1 0.0436
713 Sodium-dependent dopamine transporter SLC6A3 0.0435
136 Estrogen receptor ESR1 0.0433
766 Beta-2 adrenergic receptor ADRB2 0.0432
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0431
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0416
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0409
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0408
6143 Solute carrier family 22 member 7 SLC22A7 0.0406
467 Delta-type opioid receptor OPRD1 0.038
320 5-hydroxytryptamine 1A receptor HTR1A 0.0377
318 Alpha-2A adrenergic receptor ADRA2A 0.0374
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0371
193 Beta-1 adrenergic receptor ADRB1 0.0366
696 Kappa-type opioid receptor OPRK1 0.036
590 5-hydroxytryptamine 2C receptor HTR2C 0.0353
6137 Multidrug resistance-associated protein 6 ABCC6 0.0353
632 Alpha-1B adrenergic receptor ADRA1B 0.0352
260 Cytochrome P450 51 ERG11 0.035
761 Cytochrome P450 51 ERG11 0.035
3163 Cytochrome P450 51 cyp51 0.035
6031 Cytochrome P450 3A43 CYP3A43 0.0334
23 D(1A) dopamine receptor DRD1 0.0329
6147 Solute carrier family 22 member 3 SLC22A3 0.0329
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0324
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0316
6148 Multidrug resistance-associated protein 7 ABCC10 0.0313
341 5-hydroxytryptamine 3 receptor HTR3A 0.0311
468 Cytochrome P450 4A11 CYP4A11 0.0308
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0305
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0304
465 Calmodulin CALM1 0.0303
6182 Cytochrome P450 2J2 CYP2J2 0.03
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0296
3941 Amine oxidase [flavin-containing] A MAOA 0.029
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0289
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0289
122 P2Y purinoceptor 12 P2RY12 0.0288
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0286
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0283
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0278
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0276
833 Organic cation/carnitine transporter 1 SLC22A4 0.0267
3923 Cholinesterase BCHE 0.0262
638 D(3) dopamine receptor DRD3 0.0255
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0253
614 Progesterone receptor PGR 0.0247
844 Epidermal growth factor receptor EGFR 0.0246
146 Androgen receptor AR 0.0246
1024 Solute carrier family 22 member 11 SLC22A11 0.0246
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0241
161 Tubulin beta chain TUBB 0.0233
312 Tubulin beta chain TUB2 0.0233
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0233
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0233
6141 Sodium/bile acid cotransporter SLC10A1 0.0232
3939 Amine oxidase [flavin-containing] B MAOB 0.0231
6136 Multidrug resistance-associated protein 5 ABCC5 0.023
4604 Liver carboxylesterase 1 CES1 0.023
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0225
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0224
789 Alpha-1D adrenergic receptor ADRA1D 0.0224
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0223
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0218
4120 NADPH--cytochrome P450 reductase POR 0.0215
380 Cytochrome P450 17A1 CYP17A1 0.0213
891 Dihydropteroate synthase folP 0.0212
5359 Dihydropteroate synthase folP 0.0212
7175 Dihydropteroate synthase sulI 0.0212
29 Tubulin beta-1 chain TUBB1 0.0212
885 5-hydroxytryptamine 1B receptor HTR1B 0.0212
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0209
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0209
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0209
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0206
504 Mast/stem cell growth factor receptor KIT 0.0205
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0201
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.02
952 Dipeptidyl peptidase 4 DPP4 0.0198
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0198
70 Type-1 angiotensin II receptor AGTR1 0.0191
629 Alpha-2B adrenergic receptor ADRA2B 0.0189
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0184
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.018
725 5-hydroxytryptamine 1D receptor HTR1D 0.018
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0179
124 Histamine H2 receptor HRH2 0.0178
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0173
811 Translocator protein TSPO 0.0172
869 Estrogen receptor beta ESR2 0.017
6220 Aryl hydrocarbon receptor AHR 0.017
378 Alpha-2C adrenergic receptor ADRA2C 0.0166
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0163
737 Mineralocorticoid receptor NR3C2 0.0162
436 5-hydroxytryptamine 2B receptor HTR2B 0.0161
756 Sex hormone-binding globulin SHBG 0.0161
407 Vascular endothelial growth factor receptor 2 KDR 0.0161
738 Monocarboxylate transporter 1 SLC16A1 0.0159
432 D(4) dopamine receptor DRD4 0.0159
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0156
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0154
26 Vascular endothelial growth factor receptor 3 FLT4 0.0152
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0152
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0152
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0152
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0152
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
1656 CYP2B protein CYP2B 0.0149
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0147
777 Tumor necrosis factor TNF 0.0146
818 50S ribosomal protein L10 rplJ 0.0146
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0146
32 Vascular endothelial growth factor receptor 1 FLT1 0.0146
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0145
6085 Fatty acid-binding protein, intestinal FABP2 0.0144
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0142
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0142
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0142
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0142
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0142
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0141
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0141
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0139
716 5-hydroxytryptamine 7 receptor HTR7 0.0137
228 Beta platelet-derived growth factor receptor PDGFRB 0.0137
1010 Cytochrome P450 51A1 CYP51A1 0.0137
474 Acetylcholinesterase ACHE 0.0137
373 Transthyretin TTR 0.0137
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0137
477 DNA topoisomerase 4 subunit A parC 0.0135
886 DNA topoisomerase 4 subunit A parC 0.0135
6226 DNA topoisomerase 4 subunit A parC 0.0135
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
6599 HTH-type transcriptional regulator ttgR ttgR 0.0134
404 DNA gyrase subunit A gyrA 0.0133
6224 DNA gyrase subunit A gyrA 0.0133
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0132
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0131
174 Sigma 1-type opioid receptor SIGMAR1 0.0131
3307 Acriflavine resistance protein B acrB 0.013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0129
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0128
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0128
365 Dihydrofolate reductase DHFR 0.0127
2381 Dihydrofolate reductase DFR1 0.0127
2833 Dihydrofolate reductase Not Available 0.0127
2931 Dihydrofolate reductase folA 0.0127
3544 Dihydrofolate reductase folA 0.0127
3682 Dihydrofolate reductase folA 0.0127
6642 Dihydrofolate reductase folA 0.0127
6756 Dihydrofolate reductase dfrA 0.0127
94 5-hydroxytryptamine 4 receptor HTR4 0.0127
723 Cytosolic phospholipase A2 PLA2G4A 0.0127
427 Substance-P receptor TACR1 0.0127
6102 Arylamine N-acetyltransferase 2 NAT2 0.0125
2539 Tubulin alpha-1 chain TUBA4A 0.0124
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0123
6138 Multidrug resistance protein 3 ABCB4 0.0123
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0121
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.012
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
705 Glutamate receptor 1 GRIA1 0.0118
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0118
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0117
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0116
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0115
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0115
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0113
273 Apoptosis regulator Bcl-2 BCL2 0.0112
4237 50S ribosomal protein L22 rplV 0.0111
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0111
1852 Microtubule-associated protein 2 MAP2 0.011
1192 Sulfotransferase 1A1 SULT1A1 0.0108
131 Synaptic vesicular amine transporter SLC18A2 0.0108
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0107
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
3947 Xanthine dehydrogenase/oxidase XDH 0.0105
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0105
1050 Bile salt sulfotransferase SULT2A1 0.0104
1757 Myeloperoxidase MPO 0.0102
295 Carbonic anhydrase 1 CA1 0.0101
183 Vascular endothelial growth factor A VEGFA 0.0101
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
163 D(1B) dopamine receptor DRD5 0.0101
4238 50S ribosomal protein L4 rplD 0.01
5578 50S ribosomal protein L4 rplD 0.01
6173 50S ribosomal protein L4 rplD 0.01
6219 50S ribosomal protein L4 rplD 0.01
6020 Aldehyde oxidase AOX1 0.0099
1353 DNA topoisomerase 1 TOP1 0.0099
3552 DNA topoisomerase 1 topA 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
6014 Cytochrome P450 2A13 CYP2A13 0.0098
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0096
4203 Histamine N-methyltransferase HNMT 0.0096
921 Glutamate receptor 2 GRIA2 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
5787 Angiopoietin-1 receptor TEK 0.0096
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0096
49 Endothelin B receptor EDNRB 0.0096
1629 Transcription factor AP-1 JUN 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0094
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0094
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0094
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
5923 Microtubule-associated protein tau MAPT 0.0091
5924 Microtubule-associated protein 4 MAP4 0.0091
275 Arachidonate 5-lipoxygenase ALOX5 0.009
578 Endothelin-1 receptor EDNRA 0.009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
3932 Glutathione S-transferase A2 GSTA2 0.0088
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0087
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0087
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0087
319 Opioid receptor, sigma 1 OPRS1 0.0086
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0085
2449 Tubulin alpha-3 chain TUBA1A 0.0085
528 5-hydroxytryptamine 1E receptor HTR1E 0.0085
3810 Catechol O-methyltransferase COMT 0.0085
1256 5-hydroxytryptamine 6 receptor HTR6 0.0085
823 Fibroblast growth factor receptor 2 FGFR2 0.0085
24 Thymidylate synthase TMP1 0.0084
359 Thymidylate synthase TYMS 0.0084
2626 Thymidylate synthase thyA 0.0084
2729 Thymidylate synthase thyA 0.0084
5352 Thymidylate synthase THYA 0.0084
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0084
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
165 FL cytokine receptor FLT3 0.0083
1618 High affinity nerve growth factor receptor NTRK1 0.0083
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0082
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0081
239 Coagulation factor X F10 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
208 DNA-directed RNA polymerase beta' chain rpoC 0.008
5774 DNA-directed RNA polymerase beta' chain rpoC 0.008
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0078
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
88 Retinoic acid receptor RXR-beta RXRB 0.0078
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0077
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0077
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0076
904 Glutathione S-transferase P GSTP1 0.0075
1178 Adenosine A2a receptor ADORA2A 0.0075
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0075
1541 Metalloproteinase mmp20 0.0074
4192 DNA topoisomerase 2-beta TOP2B 0.0073
357 Carbonic anhydrase 2 CA2 0.0072
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0072
54 Prothrombin F2 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
537 ATP synthase delta chain, mitochondrial ATP5D 0.007
814 Ryanodine receptor 1 RYR1 0.007
469 Annexin A1 ANXA1 0.007
84 Nuclear receptor 0B1 NR0B1 0.007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.007
33 Cystine/glutamate transporter SLC7A11 0.007
284 DNA-directed RNA polymerase beta chain rpoB 0.007
5773 DNA-directed RNA polymerase beta chain rpoB 0.007
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0068
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0068
6149 Solute carrier family 22 member 10 SLC22A10 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0067
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
3809 Estrogen-related receptor gamma ESRRG 0.0067
4311 tRNA TRDMT1 0.0067
4325 tRNA trmD 0.0067
4328 tRNA trmD 0.0067
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0066
1630 Integrin beta-2 ITGB2 0.0066
581 Cytochrome P450 2R1 CYP2R1 0.0065
461 Glycine receptor subunit alpha-3 GLRA3 0.0065
4773 Deoxycytidine kinase DCK 0.0065
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0064
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0064
4122 Histone deacetylase 2 HDAC2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0063
780 Retinoic acid receptor RXR-gamma RXRG 0.0062
2981 Phospholipase A2, membrane associated PLA2G2A 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
6432 Transporter snf 0.0061
7 Nitric oxide synthase, inducible NOS2 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
518 Peroxidase/catalase T katG 0.006
6126 Carbonic anhydrase 7 CA7 0.006
1196 Complement decay-accelerating factor CD55 0.006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0059
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0059
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
16 Adenosine A1 receptor ADORA1 0.0057
908 Glutathione S-transferase theta-1 GSTT1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
563 Thyroid peroxidase TPO 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0055
6043 Putative G-protein coupled receptor 44 GPR44 0.0055
6506 Stathmin-4 STMN4 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
1517 Beta-3 adrenergic receptor ADRB3 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
6212 Tubulin gamma-1 chain TUBG1 0.0053
6210 Tubulin delta chain TUBD1 0.0053
6211 Tubulin epsilon chain TUBE1 0.0053
162 Retinoic acid receptor gamma-1 RARG 0.0052
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
976 Platelet glycoprotein IX GP9 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0052
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0052
1992 Vitamin D-binding protein GC 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0051
489 Monocarboxylate transporter 2 SLC16A7 0.0051
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0051
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0051
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
2599 Tyrosine-protein kinase HCK HCK 0.005
173 Toll-like receptor 7 TLR7 0.0049
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0049
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
3601 Dihydropteroate synthase 1 folP1 0.0047
3807 Dihydropteroate synthase 1 folP1 0.0047
3808 Dihydropteroate synthase 2 folP2 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0046
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0046
936 Ephrin type-A receptor 2 EPHA2 0.0046
2021 Thrombomodulin THBD 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6167 Organic solute transporter subunit beta OSTB 0.0045
6166 Organic solute transporter subunit alpha OSTA 0.0045
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0045
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0045
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0044
130 Prostacyclin synthase PTGIS 0.0044
5934 Cytochrome P450 26A1 CYP26A1 0.0043
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
6044 Serum paraoxonase/lactonase 3 PON3 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0042
6837 Serine/threonine-protein kinase 17B STK17B 0.0042
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0042
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
6218 Pannexin-1 PANX1 0.004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
572 Integrin alpha-L ITGAL 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
164 Histamine H4 receptor HRH4 0.0038
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
6048 Troponin C, skeletal muscle TNNC2 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0037
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0037
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
719 Retinoic acid receptor responder protein 1 RARRES1 0.0037
770 Retinoic acid-induced protein 3 GPRC5A 0.0037
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0037
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0037
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0036
291 Nitric-oxide synthase, endothelial NOS3 0.0036
702 UMP-CMP kinase CMPK1 0.0036
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
6221 Steroid hormone receptor ERR1 ESRRA 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0034
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
1039 Histone deacetylase 9 HDAC9 0.0034
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0034
3937 Fatty-acid amide hydrolase FAAH 0.0034
3587 Gastrotropin FABP6 0.0033
5880 Thrombopoietin receptor MPL 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
517 Alcohol dehydrogenase 1C ADH1C 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1864 RET proto-oncogene RET 0.0031
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0031
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0031
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0031
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0031
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0031
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0031
1792 Tissue-type plasminogen activator PLAT 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0031
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0031
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0031
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0031
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0031
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.003
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.003
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
342 P protein [Includes: DNA-directed DNA polymerase P 0.003
612 P protein [Includes: DNA-directed DNA polymerase P 0.003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
444 Alcohol dehydrogenase 1B ADH1B 0.0029
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0029
251 Alcohol dehydrogenase 1A ADH1A 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1313 Lactoylglutathione lyase GLO1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0028
172 Potassium channel subfamily K member 1 KCNK1 0.0028
6042 Prostaglandin reductase 2 PTGR2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
1650 Heme carrier protein 1 SLC46A1 0.0027
2207 Rhodopsin RHO 0.0027
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
2320 Thymidine kinase, cytosolic TK1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
5626 Nucleoside diphosphate kinase B NME2 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
3957 Adenosine deaminase ADA 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1360 Sphingomyelin phosphodiesterase SMPD1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
76 Nitric-oxide synthase, brain NOS1 0.0024
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
5294 Nucleoside diphosphate kinase A NME1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
5818 Folate receptor alpha FOLR1 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
4041 Microsomal glutathione S-transferase 2 MGST2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
3830 Calreticulin CALR 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
293 Gamma-glutamyl hydrolase GGH 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
3233 Bile acid receptor NR1H4 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4031 Glutathione S-transferase A1 GSTA1 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
3221 Cytochrome c4 cc4 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
6501 Fatty acid-binding protein, liver FABP1 0.0013
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6500 Phospholipase A2 PLA2G1B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2298 Cytochrome P450-cam camC 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
1507 Cytochrome c CYCS 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
714 Glutathione reductase, mitochondrial GSR 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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