DT-Web: DB00404

Identification

Name

Alprazolam

Accession Number

DB00404 (APRD00280)

Type

small molecule

Description

A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

308.765

Groups

illicit

Monoisotopic Weight

308.082874143

Pharmacology

Indication

For the management of anxiety disorder or the short-term relief of symptoms of anxiety and for the treatment of panic disorder, with or without agoraphobia.

Mechanism of action

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Absorption

Readily absorbed from the gastrointestinal tract. Bioavailability is 80-90%.

Protein binding

80% (mainly to albumin)

Biotransformation

Hepatic. Hydroxylated in the liver to α-hydroxyalprazolam, which is also active. This and other metabolites are later excreted in urine as glucuronides.

Route of elimination

Alprazolam and its metabolites are excreted primarily in the urine.

Toxicity

Oral, mouse: LD₅₀=1020 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amprenavir	Amprenavir may increase the effect and toxicity of the benzodiazepine, alprazolam.
Aprepitant	Aprepitant may increase the effect and toxicity of the benzodiazepine, alprazolam.
Carbamazepine	Carbamazepine may decrease the effect of the benzodiazepine, alprazolam.
Cimetidine	Cimetidine may increase the effect of the benzodiazepine, alprazolam.
Clarithromycin	The macrolide, clarithromycin, may increase the effect of the benzodiazepine, alprazolam.
Clozapine	Increased risk of toxicity
Delavirdine	The antiviral agent, delavirdine, may increase the effect and toxicity of the benzodiazepine, alprazolam.
Digoxin	The benzodiazepine, alprazolam, may increase the effect of digoxin.
Efavirenz	The antiviral agent, efavirenz, may increase the effect and toxicity of the benzodiazepine, alprazolam.
Erythromycin	The macrolide, erythromycin, may increase the effect of the benzodiazepine, alprazolam.
Ethotoin	Ethotoin may increase the metabolism of alprazolam via CYP3A4.
Fluconazole	Fluconazole may increase the effect of the benzodiazepine, alprazolam.
Fosamprenavir	Fosamprenavir may increase the effect and toxicity of the benzodiazepine, alprazolam.
Fosphenytoin	Fosphenytoin may increase the metabolism of alprazolam via CYP3A4.
Indinavir	The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, alprazolam.
Itraconazole	Itraconazole may increase the effect of the benzodiazepine, alprazolam.
Josamycin	The macrolide, josamycin, may increase the effect of the benzodiazepine, alprazolam.
Kava	Kava may increase the effect of the benzodiazepine, alprazolam.
Ketoconazole	Ketoconazole may increase the effect of the benzodiazepine, alprazolam.
Mephenytoin	Mephenytoin may increase the metabolism of alprazolam via CYP3A4.
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, alprazolam.
Omeprazole	Omeprazole may increase the effect of the benzodiazepine, alprazolam.
Phenytoin	Phenytoin may increase the metabolism of alprazolam via CYP3A4.
Ritonavir	The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, alprazolam.
Saquinavir	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, alprazolam.
St. John's Wort	St. John's Wort may decrease the effect of the benzodiazepine, alprazolam.
Telaprevir	Telaprevir inhibits systemic metabolism of alprazolam and dose adjustment may be necessary.
Telithromycin	Telithromycin may increase the effect and toxicity of the benzodiazepine, alprazolam.
Tipranavir	Tipranavir may decrease the metabolism and clearance of Alprazolam. Consider alternate therapy or monitor for Alprazolam toxic effects if Tipranavir is initiated or dose increased.
Triprolidine	The CNS depressants, Triprolidine and Alprazolam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole	Voriconazole may increase the serum concentration of alprazolam by decreasing its metabolism. Monitor for alprazolam toxicity if voriconazole is initiated or dose increased.

Food Interactions

Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.
Avoid taking with grapefruit juice.

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2957
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2205
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2179
Gamma-aminobutyric-acid receptor subunit alpha-4
Name	Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name	GABRA4
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8659
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2415
Gamma-aminobutyric-acid receptor subunit alpha-6
Name	Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name	GABRA6
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8319
Gamma-aminobutyric-acid receptor subunit beta-1
Name	Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name	GABRB1
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0925
Gamma-aminobutyric-acid receptor subunit beta-2
Name	Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name	GABRB2
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0725
Gamma-aminobutyric-acid receptor subunit beta-3
Name	Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name	GABRB3
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0863
Gamma-aminobutyric acid receptor subunit gamma-1
Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	GABRG1
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.082
Gamma-aminobutyric acid receptor subunit gamma-2
Name	Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name	GABRG2
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1059
Gamma-aminobutyric acid receptor subunit gamma-3
Name	Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name	GABRG3
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0545
Gamma-aminobutyric acid receptor subunit delta
Name	Gamma-aminobutyric acid receptor subunit delta
Gene Name	GABRD
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0706
Gamma-aminobutyric acid receptor subunit epsilon
Name	Gamma-aminobutyric acid receptor subunit epsilon
Gene Name	GABRE
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0687
Gamma-aminobutyric acid receptor subunit pi
Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0452
Gamma-aminobutyric-acid receptor subunit rho-1
Name	Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name	GABRR1
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0502
Gamma-aminobutyric acid receptor subunit rho-2
Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0561
Gamma-aminobutyric acid receptor subunit theta
Name	Gamma-aminobutyric acid receptor subunit theta
Gene Name	GABRQ
Pharmacological action	yes
Actions	potentiator
References	Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.706
Gamma-aminobutyric acid receptor subunit rho-3
Name	Gamma-aminobutyric acid receptor subunit rho-3
Gene Name	GABRR3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0531
Translocator protein
Name	Translocator protein
Gene Name	TSPO
Pharmacological action	unknown
Actions	other
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6243

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. - Pubmed
DTHybrid score	0.9224
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4537
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3977
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4823

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.4048
1588	Multidrug resistance protein 1	ABCB1	0.3013
6013	Cytochrome P450 2E1	CYP2E1	0.29
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.2899
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.2898
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.2826
4924	Cytochrome P450 2C8	CYP2C8	0.2706
6030	Cytochrome P450 2B6	CYP2B6	0.2523
921	Glutamate receptor 2	GRIA2	0.2495
4119	Cytochrome P450 2D6	CYP2D6	0.2458
4200	Cytochrome P450 1A2	CYP1A2	0.2256
587	Serum albumin	ALB	0.1461
6106	Cytochrome P450 2C18	CYP2C18	0.1369
20	Prostaglandin G/H synthase 1	PTGS1	0.1158
5718	Cytochrome P450 2A6	CYP2A6	0.115
6024	Cytochrome P450 1A1	CYP1A1	0.077
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0691
6031	Cytochrome P450 3A43	CYP3A43	0.0689
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0607
6102	Arylamine N-acetyltransferase 2	NAT2	0.058
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0567
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.054
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0524
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0522
6145	Solute carrier family 22 member 1	SLC22A1	0.0515
6144	Solute carrier family 22 member 2	SLC22A2	0.0493
862	Multidrug resistance-associated protein 1	ABCC1	0.0471
482	Glycine receptor subunit alpha-1	GLRA1	0.0459
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0429
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0419
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0388
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0367
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0361
461	Glycine receptor subunit alpha-3	GLRA3	0.0352
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.035
492	Histamine H1 receptor	HRH1	0.0344
1898	Cytochrome P450 1B1	CYP1B1	0.0343
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.034
847	Mu-type opioid receptor	OPRM1	0.0332
3811	Cytochrome P450 19A1	CYP19A1	0.0309
776	Bile salt export pump	ABCB11	0.0306
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0303
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0294
820	Glycine receptor subunit alpha-2	GLRA2	0.0293
824	Sodium-dependent serotonin transporter	SLC6A4	0.0292
290	Prostaglandin G/H synthase 2	PTGS2	0.0281
502	5-hydroxytryptamine 2A receptor	HTR2A	0.027
1729	Solute carrier family 22 member 6	SLC22A6	0.027
871	Glucocorticoid receptor	NR3C1	0.0269
6020	Aldehyde oxidase	AOX1	0.0249
831	D(2) dopamine receptor	DRD2	0.0245
556	Alpha-1A adrenergic receptor	ADRA1A	0.0245
3937	Fatty-acid amide hydrolase	FAAH	0.0239
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0237
467	Delta-type opioid receptor	OPRD1	0.0229
318	Alpha-2A adrenergic receptor	ADRA2A	0.0224
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0221
731	HIV-1 protease	HIV-1 protease	0.022
468	Cytochrome P450 4A11	CYP4A11	0.021
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0203
136	Estrogen receptor	ESR1	0.0203
696	Kappa-type opioid receptor	OPRK1	0.0203
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0201
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.02
705	Glutamate receptor 1	GRIA1	0.0199
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0196
6143	Solute carrier family 22 member 7	SLC22A7	0.0195
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0191
23	D(1A) dopamine receptor	DRD1	0.0188
3426	Glutamine synthetase	glnA	0.0188
3987	Glutamine synthetase	GLUL	0.0188
260	Cytochrome P450 51	ERG11	0.0188
761	Cytochrome P450 51	ERG11	0.0188
3163	Cytochrome P450 51	cyp51	0.0188
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0185
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0181
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0175
614	Progesterone receptor	PGR	0.0175
2164	Multidrug resistance-associated protein 4	ABCC4	0.0173
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0173
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0172
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0171
51	Muscarinic acetylcholine receptor M3	CHRM3	0.017
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0161
6142	Solute carrier family 22 member 8	SLC22A8	0.016
590	5-hydroxytryptamine 2C receptor	HTR2C	0.016
6182	Cytochrome P450 2J2	CYP2J2	0.0159
172	Potassium channel subfamily K member 1	KCNK1	0.0158
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0158
638	D(3) dopamine receptor	DRD3	0.0157
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0154
632	Alpha-1B adrenergic receptor	ADRA1B	0.0152
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0152
738	Monocarboxylate transporter 1	SLC16A1	0.0152
713	Sodium-dependent dopamine transporter	SLC6A3	0.0152
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
617	Muscarinic acetylcholine receptor M2	CHRM2	0.015
537	ATP synthase delta chain, mitochondrial	ATP5D	0.015
737	Mineralocorticoid receptor	NR3C2	0.0148
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0145
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0145
118	Organic cation/carnitine transporter 2	SLC22A5	0.0144
232	Corticosteroid-binding globulin	SERPINA6	0.0143
6148	Multidrug resistance-associated protein 7	ABCC10	0.0142
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0141
817	DNA topoisomerase 2-alpha	TOP2A	0.0137
629	Alpha-2B adrenergic receptor	ADRA2B	0.0136
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0134
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0133
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0133
62	Glycine receptor subunit beta	GLRB	0.0132
766	Beta-2 adrenergic receptor	ADRB2	0.0132
6147	Solute carrier family 22 member 3	SLC22A3	0.0128
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0128
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0126
489	Monocarboxylate transporter 2	SLC16A7	0.0126
122	P2Y purinoceptor 12	P2RY12	0.0123
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0123
500	Monocarboxylate transporter 4	SLC16A3	0.0118
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0117
891	Dihydropteroate synthase	folP	0.0116
5359	Dihydropteroate synthase	folP	0.0116
7175	Dihydropteroate synthase	sulI	0.0116
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0115
756	Sex hormone-binding globulin	SHBG	0.0115
465	Calmodulin	CALM1	0.0114
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0112
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0112
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0111
378	Alpha-2C adrenergic receptor	ADRA2C	0.0106
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0105
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0103
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0098
29	Tubulin beta-1 chain	TUBB1	0.0098
592	Carbonic anhydrase 4	CA4	0.0097
70	Type-1 angiotensin II receptor	AGTR1	0.0097
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0096
504	Mast/stem cell growth factor receptor	KIT	0.0096
818	50S ribosomal protein L10	rplJ	0.0095
432	D(4) dopamine receptor	DRD4	0.0095
833	Organic cation/carnitine transporter 1	SLC22A4	0.0095
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
844	Epidermal growth factor receptor	EGFR	0.0092
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0091
146	Androgen receptor	AR	0.0091
407	Vascular endothelial growth factor receptor 2	KDR	0.0091
427	Substance-P receptor	TACR1	0.0089
1024	Solute carrier family 22 member 11	SLC22A11	0.0088
789	Alpha-1D adrenergic receptor	ADRA1D	0.0088
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0088
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0087
3941	Amine oxidase [flavin-containing] A	MAOA	0.0087
4604	Liver carboxylesterase 1	CES1	0.0086
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0085
6220	Aryl hydrocarbon receptor	AHR	0.0085
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0084
768	FK506-binding protein 1A	FKBP1A	0.0083
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0082
228	Beta platelet-derived growth factor receptor	PDGFRB	0.008
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.008
6136	Multidrug resistance-associated protein 5	ABCC5	0.0079
94	5-hydroxytryptamine 4 receptor	HTR4	0.0079
716	5-hydroxytryptamine 7 receptor	HTR7	0.0079
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0078
26	Vascular endothelial growth factor receptor 3	FLT4	0.0077
723	Cytosolic phospholipase A2	PLA2G4A	0.0077
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0077
6137	Multidrug resistance-associated protein 6	ABCC6	0.0076
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0075
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0075
1010	Cytochrome P450 51A1	CYP51A1	0.0074
295	Carbonic anhydrase 1	CA1	0.0074
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0074
193	Beta-1 adrenergic receptor	ADRB1	0.0074
32	Vascular endothelial growth factor receptor 1	FLT1	0.0074
477	DNA topoisomerase 4 subunit A	parC	0.0074
886	DNA topoisomerase 4 subunit A	parC	0.0074
6226	DNA topoisomerase 4 subunit A	parC	0.0074
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0074
404	DNA gyrase subunit A	gyrA	0.0073
6224	DNA gyrase subunit A	gyrA	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0072
357	Carbonic anhydrase 2	CA2	0.0071
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0071
3939	Amine oxidase [flavin-containing] B	MAOB	0.0071
3923	Cholinesterase	BCHE	0.0069
49	Endothelin B receptor	EDNRB	0.0069
380	Cytochrome P450 17A1	CYP17A1	0.0069
777	Tumor necrosis factor	TNF	0.0069
1656	CYP2B protein	CYP2B	0.0068
4237	50S ribosomal protein L22	rplV	0.0068
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0067
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0067
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0066
952	Dipeptidyl peptidase 4	DPP4	0.0066
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0065
6141	Sodium/bile acid cotransporter	SLC10A1	0.0065
4120	NADPH--cytochrome P450 reductase	POR	0.0065
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0064
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0064
161	Tubulin beta chain	TUBB	0.0063
312	Tubulin beta chain	TUB2	0.0063
133	Dihydropterate synthase	sulI	0.0063
54	Prothrombin	F2	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0062
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0062
814	Ryanodine receptor 1	RYR1	0.0061
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0061
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0061
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0059
1852	Microtubule-associated protein 2	MAP2	0.0059
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0058
869	Estrogen receptor beta	ESR2	0.0057
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0056
165	FL cytokine receptor	FLT3	0.0056
4238	50S ribosomal protein L4	rplD	0.0054
5578	50S ribosomal protein L4	rplD	0.0054
6173	50S ribosomal protein L4	rplD	0.0054
6219	50S ribosomal protein L4	rplD	0.0054
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0053
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0053
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0053
5923	Microtubule-associated protein tau	MAPT	0.0053
5924	Microtubule-associated protein 4	MAP4	0.0053
124	Histamine H2 receptor	HRH2	0.0053
1196	Complement decay-accelerating factor	CD55	0.0052
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0051
469	Annexin A1	ANXA1	0.0051
1757	Myeloperoxidase	MPO	0.0051
153	Dopamine beta-hydroxylase	DBH	0.0051
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0051
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0051
273	Apoptosis regulator Bcl-2	BCL2	0.0051
3810	Catechol O-methyltransferase	COMT	0.005
275	Arachidonate 5-lipoxygenase	ALOX5	0.005
163	D(1B) dopamine receptor	DRD5	0.005
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.005
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0049
6014	Cytochrome P450 2A13	CYP2A13	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
780	Retinoic acid receptor RXR-gamma	RXRG	0.0048
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0047
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0047
4203	Histamine N-methyltransferase	HNMT	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
84	Nuclear receptor 0B1	NR0B1	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
239	Coagulation factor X	F10	0.0046
1050	Bile salt sulfotransferase	SULT2A1	0.0045
2808	Chloramphenicol acetyltransferase 3	cat3	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0045
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0045
474	Acetylcholinesterase	ACHE	0.0045
284	DNA-directed RNA polymerase beta chain	rpoB	0.0044
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
88	Retinoic acid receptor RXR-beta	RXRB	0.0043
365	Dihydrofolate reductase	DHFR	0.0043
2381	Dihydrofolate reductase	DFR1	0.0043
2833	Dihydrofolate reductase	Not Available	0.0043
2931	Dihydrofolate reductase	folA	0.0043
3544	Dihydrofolate reductase	folA	0.0043
3682	Dihydrofolate reductase	folA	0.0043
6642	Dihydrofolate reductase	folA	0.0043
6756	Dihydrofolate reductase	dfrA	0.0043
4773	Deoxycytidine kinase	DCK	0.0043
6085	Fatty acid-binding protein, intestinal	FABP2	0.0042
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0042
3601	Dihydropteroate synthase 1	folP1	0.0041
3807	Dihydropteroate synthase 1	folP1	0.0041
3808	Dihydropteroate synthase 2	folP2	0.0041
2417	Chloramphenicol acetyltransferase	cat	0.0041
3278	Chloramphenicol acetyltransferase	cat	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0041
856	Vitamin D3 receptor	VDR	0.0041
2810	Dr hemagglutinin structural subunit	draA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.004
16	Adenosine A1 receptor	ADORA1	0.004
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.004
4122	Histone deacetylase 2	HDAC2	0.004
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0039
1541	Metalloproteinase	mmp20	0.0039
1178	Adenosine A2a receptor	ADORA2A	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1275	Estrogen sulfotransferase	SULT1E1	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
823	Fibroblast growth factor receptor 2	FGFR2	0.0038
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
3947	Xanthine dehydrogenase/oxidase	XDH	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
319	Opioid receptor, sigma 1	OPRS1	0.0037
1618	High affinity nerve growth factor receptor	NTRK1	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0035
1630	Integrin beta-2	ITGB2	0.0035
5300	Antigen peptide transporter 1	TAP1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
976	Platelet glycoprotein IX	GP9	0.0035
939	50S ribosomal protein L3	rplC	0.0035
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0034
24	Thymidylate synthase	TMP1	0.0034
359	Thymidylate synthase	TYMS	0.0034
2626	Thymidylate synthase	thyA	0.0034
2729	Thymidylate synthase	thyA	0.0034
5352	Thymidylate synthase	THYA	0.0034
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
183	Vascular endothelial growth factor A	VEGFA	0.0033
6174	50S ribosomal protein L32	rpmF	0.0033
3932	Glutathione S-transferase A2	GSTA2	0.0033
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0033
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0033
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
3086	Plasmepsin-2	Not Available	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
174	Sigma 1-type opioid receptor	SIGMAR1	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
719	Retinoic acid receptor responder protein 1	RARRES1	0.003
770	Retinoic acid-induced protein 3	GPRC5A	0.003
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0029
3809	Estrogen-related receptor gamma	ESRRG	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
6044	Serum paraoxonase/lactonase 3	PON3	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0028
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0028
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0028
33	Cystine/glutamate transporter	SLC7A11	0.0028
1517	Beta-3 adrenergic receptor	ADRB3	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0028
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0027
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0027
1192	Sulfotransferase 1A1	SULT1A1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0027
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0026
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0026
572	Integrin alpha-L	ITGAL	0.0026
373	Transthyretin	TTR	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0026
267	Plasminogen activator inhibitor 1	SERPINE1	0.0026
1864	RET proto-oncogene	RET	0.0026
1629	Transcription factor AP-1	JUN	0.0025
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0025
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0025
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
444	Alcohol dehydrogenase 1B	ADH1B	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0025
2112	Toll-like receptor 9	TLR9	0.0025
1648	Elastin	ELN	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
131	Synaptic vesicular amine transporter	SLC18A2	0.0023
5934	Cytochrome P450 26A1	CYP26A1	0.0023
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0023
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0023
6221	Steroid hormone receptor ERR1	ESRRA	0.0023
4311	tRNA	TRDMT1	0.0023
4325	tRNA	trmD	0.0023
4328	tRNA	trmD	0.0023
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0023
1268	Neuropeptide S receptor	NPSR1	0.0023
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0023
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0023
581	Cytochrome P450 2R1	CYP2R1	0.0023
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0022
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0022
5787	Angiopoietin-1 receptor	TEK	0.0022
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
517	Alcohol dehydrogenase 1C	ADH1C	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0021
4192	DNA topoisomerase 2-beta	TOP2B	0.0021
6073	Potassium channel subfamily K member 9	KCNK9	0.002
6072	Potassium channel subfamily K member 3	KCNK3	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.002
904	Glutathione S-transferase P	GSTP1	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
162	Retinoic acid receptor gamma-1	RARG	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
518	Peroxidase/catalase T	katG	0.0018
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0018
164	Histamine H4 receptor	HRH4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
936	Ephrin type-A receptor 2	EPHA2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
7	Nitric oxide synthase, inducible	NOS2	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
683	Potassium transporter	GK0582	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0017
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0016
6149	Solute carrier family 22 member 10	SLC22A10	0.0016
3856	Fibroblast growth factor receptor 3	FGFR3	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
563	Thyroid peroxidase	TPO	0.0016
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
634	Squalene monooxygenase	SQLE	0.0015
7196	Squalene monooxygenase	ERG1	0.0015
558	Solute carrier family 12 member 1	SLC12A1	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
2207	Rhodopsin	RHO	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
6146	High affinity copper uptake protein 1	SLC31A1	0.0014
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0014
6432	Transporter	snf	0.0014
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1039	Histone deacetylase 9	HDAC9	0.0014
2216	Fibroblast growth factor receptor 4	FGFR4	0.0014
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0014
908	Glutathione S-transferase theta-1	GSTT1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
1650	Heme carrier protein 1	SLC46A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
1992	Vitamin D-binding protein	GC	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4103	Proteasome subunit beta type 2	PSMB2	0.0011
4101	Proteasome subunit beta type 1	PSMB1	0.0011
4102	Proteasome subunit beta type 5	PSMB5	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
1374	Natriuretic peptides B	NPPB	0.0011
1827	Gap junction alpha-1 protein	GJA1	0.0011
1908	Vascular cell adhesion protein 1	VCAM1	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
4217	Telomerase reverse transcriptase	TERT	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
511	5-hydroxytryptamine 1F receptor	HTR1F	0.001
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.001
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.001
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0009
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
3830	Calreticulin	CALR	0.0008
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0008
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0008
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0008
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0008
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
2298	Cytochrome P450-cam	camC	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6218	Pannexin-1	PANX1	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3221	Cytochrome c4	cc4	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
3957	Adenosine deaminase	ADA	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
291	Nitric-oxide synthase, endothelial	NOS3	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0005
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1507	Cytochrome c	CYCS	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00404 - Alprazolam

Targets

Enzymes

Predictions