DT-Web

DB00705 - Delavirdine


Identification
Name Delavirdine
Accession Number DB00705 (APRD00149, DB08563)
Type small molecule
Description A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 456.561
Groups approved
Monoisotopic Weight 456.194359482
Pharmacology
Indication For the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
Mechanism of action Delavirdine binds directly to viral reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Absorption Rapidly absorbed
Protein binding 98%
Biotransformation Hepatic
Route of elimination Delavirdine is extensively converted to several inactive metabolites by cytochrome P450 3A (CYP3A). Delavirdine was excreted in the milk of lactating rats at a concentration three to five times that of rat plasma.
Toxicity Major toxicity of delavirdine is rash and should be advised to promptly notify their physician should rash occur. The majority of rashes associated with delavirdine occur within 1 to 3 weeks after initiating treatment with delavirdine. The rash normally resolves in 3 to 14 days and may be treated symptomatically while therapy with delavirdine is continued. Any patient experiencing severe rash or rash accompanied by symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Alprazolam The antiviral agent, delavirdine, may increase the effect and toxicity of the benzodiazepine, alprazolam.
Aluminium The antiacid decreases the effect of delavirdine
Amprenavir Decreased levels of delavirdine with increased levels of amprenavir
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atorvastatin Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if delavirdine is initiated, discontinued or dose changed.
Bromazepam Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if delavirdine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Calcium The antiacid decreases the effect of delavirdine
Carbamazepine The anticonvulsant, carbamazepine, decreases the effect of delavirdine.
Carisoprodol Strong CYP2C19 inhibitors such as delavirdine may decrease the metabolism of CYP2C19 substrates such as carisoprodol. Consider an alternative for one of the interacting drugs in order to avoid toxicity of the substrate. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of the CYP substrate if a CYP inhibitor is initiated/dose increased, and decreased effects if a CYP inhibitor is discontinued/dose decreased.
Cisapride Delavirdine, a strong CYP3A4 inhibitor, may increase the metabolism of cisapride. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of cisapride if delavirdine is initiated, discontinued or dose changed.
Dantrolene Delavirdine may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if delavirdine is initiated, discontinued or dose changed.
Dihydroergotamine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of dihydroergotamine by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dihydroergotamine if delavirdine is initiated, discontinued or dose changed.
Dihydroergotoxine The antiretroviral agent may increase the ergot derivative toxicity
Ergonovine The antiretroviral agent may increase the ergot derivative toxicity
Ergotamine The antiretroviral agent may increase the ergot derivative toxicity
Etravirine Etravirine, when used concomitantly with Delaviridine, may experience an increase in serum concentration. Combination of two NNRTIs has not been demonstrated to be of benefit to HIV therapy. It is recommended to avoid this combination.
Fosamprenavir Decreased levels of delavirdine with increased levels of amprenavir
Fosphenytoin The anticonvulsant, fosphenytoin, decreases the effect of delavirdine.
Indinavir Delavirdine may increase the effect of indinavir.
Lovastatin Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of lovastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if delavirdine is initiated, discontinued or dose changed.
Lurasidone Concomitant therapy with a strong CYP3A4 inhibitor will increase level or effect of lurasidone. Coadministration with lurasidone is contraindicated.
Magnesium Magnesium antacids may decrease the absorption of delavirdine.
Magnesium oxide The antiacid decreases the effect of delavirdine
Methylergonovine The antiretroviral agent may increase the ergot derivative toxicity
Methylphenobarbital The anticonvulsant, methylphenobarbital, decreases the effect of delavirdine.
Methysergide The antiretroviral agent may increase the ergot derivative toxicity
Midazolam The antiviral agent, delavirdine, may increase the effect and toxicity of the benzodiazepine, midazolam.
Phenobarbital The anticonvulsant, phenobarbital, decreases the effect of delavirdine.
Phenytoin The anticonvulsant, phenytoin, decreases the effect of delavirdine.
Quinupristin This combination presents an increased risk of toxicity
Rifabutin Rifabutin decreases the effect of delavirdine
Rifampin Rifampin decreases the effect of delavirdine
Rilpivirine Concentration of rilpivirine increases by affecting CYP3A4 metabolism. Concomitant use is contraindicated. Rilpivirine should not be used with other NNRTI's.
Ritonavir Increases the effect of ritonavir
Saquinavir Increases the effect of saquinavir and hepatic toxicity
Simvastatin Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of simvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of simvastatin if delavirdine is initiated, discontinued or dose changed.
St. John's Wort St. John's Wort decreases the antiretroviral effect
Tacrolimus The strong CYP3A4 inhibitor, Delavirdine, may decrease the metabolism and clearance of Tacrolimus, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Tacrolimus if Delavirdine is initiated, discontinued or dose changed.
Tadalafil Delavirdine may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Delavirdine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Delavirdine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Delavirdine is initiated, discontinued, or dose changed.
Telithromycin Delavirdine may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Delavirdine may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Delavirdine, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Delavirdine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tiagabine The strong CYP3A4 inhibitor, Delavirdine, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Delavirdine is initiated, discontinued or dose changed.
Tipranavir Concomitant use may result in increased Tipranavir and decreased Delavirdine concentrations. Monitor for altered therapeutic and adverse effects of both agents if either agent is initiated, discontinued or dose changed.
Tolbutamide Delavirdine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Delavirdine is initiated, discontinued or dose changed.
Tolterodine Delavirdine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Torasemide Delavirdine, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Delavirdine is initiated, discontinued or dose changed.
Tramadol Delavirdine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Delavirdine may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Delavirdine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Delavirdine is initiated, discontinued or dose changed.
Triazolam The antiviral agent, delavirdine, may increase the effect and toxicity of the benzodiazepine, triazolam.
Trimethoprim The strong CYP2C9 inhibitor, Delavirdine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Delavirdine is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4/CYP2D6 inhibitor, Delavirdine, may decrease the metabolism and clearance of Trimipramine, a CYP3A4/CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Delavirdine is initiated, discontinued or dose changed.
Vardenafil Delavirdine, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Delaviridine, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Delavirdine is initiated, discontinued, or dose changed.
Verapamil Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Delavirdine is initiated, discontinued or dose changed.
Vinblastine Delavirdine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Delavirdine is initiated, discontinued or dose changed.
Vincristine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Delavirdine is initiated, discontinued or dose changed.
Vinorelbine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Delavirdine is initiated, discontinued or dose changed.
Voriconazole Delavirdine, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if delavirdine is initiated, discontinued or dose changed.
Warfarin Delavirdine, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if delavirdine is initiated, discontinued or dose changed.
Zafirlukast Delavirdine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if delavirdine is initiated, discontinued or dose changed.
Zolpidem Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if delavirdine is initiated, discontinued or dose changed.
Zonisamide Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if delavirdine is initiated, discontinued or dose changed.
Zopiclone Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if delavirdine is initiated, discontinued or dose changed.
Zuclopenthixol Delavirdine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if delavirdine is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Geitmann M, Unge T, Danielson UH: Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors. J Med Chem. 2006 Apr 20;49(8):2367-74. - Pubmed
  • Xia Q, Radzio J, Anderson KS, Sluis-Cremer N: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci. 2007 Aug;16(8):1728-37. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Voorman RL, Maio SM, Payne NA, Zhao Z, Koeplinger KA, Wang X: Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J Pharmacol Exp Ther. 1998 Oct;287(1):381-8. - Pubmed
DTHybrid score 0.7706
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.552
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
DTHybrid score 0.4436
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
DTHybrid score 0.3489
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5565
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4819
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4704
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3979

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.308
6030 Cytochrome P450 2B6 CYP2B6 0.2136
6013 Cytochrome P450 2E1 CYP2E1 0.1836
6024 Cytochrome P450 1A1 CYP1A1 0.1476
5718 Cytochrome P450 2A6 CYP2A6 0.1207
20 Prostaglandin G/H synthase 1 PTGS1 0.1114
587 Serum albumin ALB 0.1105
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1026
492 Histamine H1 receptor HRH1 0.0856
6106 Cytochrome P450 2C18 CYP2C18 0.0811
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0777
824 Sodium-dependent serotonin transporter SLC6A4 0.0735
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0733
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0709
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0624
862 Multidrug resistance-associated protein 1 ABCC1 0.062
502 5-hydroxytryptamine 2A receptor HTR2A 0.0611
831 D(2) dopamine receptor DRD2 0.0596
540 Sodium-dependent noradrenaline transporter SLC6A2 0.058
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0578
6145 Solute carrier family 22 member 1 SLC22A1 0.0563
1729 Solute carrier family 22 member 6 SLC22A6 0.056
290 Prostaglandin G/H synthase 2 PTGS2 0.0556
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0528
556 Alpha-1A adrenergic receptor ADRA1A 0.0528
3811 Cytochrome P450 19A1 CYP19A1 0.0523
1898 Cytochrome P450 1B1 CYP1B1 0.0522
847 Mu-type opioid receptor OPRM1 0.0518
6144 Solute carrier family 22 member 2 SLC22A2 0.0467
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0459
320 5-hydroxytryptamine 1A receptor HTR1A 0.0459
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0451
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0442
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.044
318 Alpha-2A adrenergic receptor ADRA2A 0.0437
766 Beta-2 adrenergic receptor ADRB2 0.0435
6031 Cytochrome P450 3A43 CYP3A43 0.0432
713 Sodium-dependent dopamine transporter SLC6A3 0.0419
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0418
776 Bile salt export pump ABCB11 0.0413
590 5-hydroxytryptamine 2C receptor HTR2C 0.0403
467 Delta-type opioid receptor OPRD1 0.0394
23 D(1A) dopamine receptor DRD1 0.0391
731 HIV-1 protease HIV-1 protease 0.0386
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0382
341 5-hydroxytryptamine 3 receptor HTR3A 0.0375
871 Glucocorticoid receptor NR3C1 0.037
696 Kappa-type opioid receptor OPRK1 0.037
118 Organic cation/carnitine transporter 2 SLC22A5 0.0364
632 Alpha-1B adrenergic receptor ADRA1B 0.0363
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0354
193 Beta-1 adrenergic receptor ADRB1 0.0348
3941 Amine oxidase [flavin-containing] A MAOA 0.0344
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0341
136 Estrogen receptor ESR1 0.0338
6143 Solute carrier family 22 member 7 SLC22A7 0.0338
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0335
260 Cytochrome P450 51 ERG11 0.0334
761 Cytochrome P450 51 ERG11 0.0334
3163 Cytochrome P450 51 cyp51 0.0334
2164 Multidrug resistance-associated protein 4 ABCC4 0.0328
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0325
638 D(3) dopamine receptor DRD3 0.0321
6142 Solute carrier family 22 member 8 SLC22A8 0.0313
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0308
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0301
817 DNA topoisomerase 2-alpha TOP2A 0.0299
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0297
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0296
885 5-hydroxytryptamine 1B receptor HTR1B 0.0295
274 Muscarinic acetylcholine receptor M5 CHRM5 0.029
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0288
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0287
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0282
6182 Cytochrome P450 2J2 CYP2J2 0.028
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0264
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0264
36 Insulin receptor INSR 0.0258
465 Calmodulin CALM1 0.0258
468 Cytochrome P450 4A11 CYP4A11 0.0258
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0254
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0252
3939 Amine oxidase [flavin-containing] B MAOB 0.0251
6147 Solute carrier family 22 member 3 SLC22A3 0.0251
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.025
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0241
629 Alpha-2B adrenergic receptor ADRA2B 0.0241
725 5-hydroxytryptamine 1D receptor HTR1D 0.0239
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0238
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0238
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0235
833 Organic cation/carnitine transporter 1 SLC22A4 0.0232
614 Progesterone receptor PGR 0.0223
378 Alpha-2C adrenergic receptor ADRA2C 0.0221
789 Alpha-1D adrenergic receptor ADRA1D 0.022
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0216
432 D(4) dopamine receptor DRD4 0.0214
6148 Multidrug resistance-associated protein 7 ABCC10 0.0212
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0211
122 P2Y purinoceptor 12 P2RY12 0.021
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0208
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0204
146 Androgen receptor AR 0.0204
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0201
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0195
811 Translocator protein TSPO 0.0191
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0189
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0189
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0189
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0188
737 Mineralocorticoid receptor NR3C2 0.0188
891 Dihydropteroate synthase folP 0.0187
5359 Dihydropteroate synthase folP 0.0187
7175 Dihydropteroate synthase sulI 0.0187
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0183
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0182
504 Mast/stem cell growth factor receptor KIT 0.0182
70 Type-1 angiotensin II receptor AGTR1 0.0178
844 Epidermal growth factor receptor EGFR 0.0177
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0171
6220 Aryl hydrocarbon receptor AHR 0.0171
380 Cytochrome P450 17A1 CYP17A1 0.0169
3923 Cholinesterase BCHE 0.0169
1024 Solute carrier family 22 member 11 SLC22A11 0.0169
94 5-hydroxytryptamine 4 receptor HTR4 0.0168
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0165
777 Tumor necrosis factor TNF 0.0163
756 Sex hormone-binding globulin SHBG 0.0161
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0161
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
232 Corticosteroid-binding globulin SERPINA6 0.0156
407 Vascular endothelial growth factor receptor 2 KDR 0.0155
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0153
26 Vascular endothelial growth factor receptor 3 FLT4 0.015
436 5-hydroxytryptamine 2B receptor HTR2B 0.0149
6136 Multidrug resistance-associated protein 5 ABCC5 0.0148
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0148
6102 Arylamine N-acetyltransferase 2 NAT2 0.0146
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0146
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0145
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0144
124 Histamine H2 receptor HRH2 0.0144
4604 Liver carboxylesterase 1 CES1 0.0144
716 5-hydroxytryptamine 7 receptor HTR7 0.0144
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0144
32 Vascular endothelial growth factor receptor 1 FLT1 0.0143
228 Beta platelet-derived growth factor receptor PDGFRB 0.0143
1010 Cytochrome P450 51A1 CYP51A1 0.0141
818 50S ribosomal protein L10 rplJ 0.0139
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0138
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0138
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0138
427 Substance-P receptor TACR1 0.0138
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0137
6141 Sodium/bile acid cotransporter SLC10A1 0.0137
163 D(1B) dopamine receptor DRD5 0.0135
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0135
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0135
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0135
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0135
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0134
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0133
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0132
6137 Multidrug resistance-associated protein 6 ABCC6 0.0132
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0132
16 Adenosine A1 receptor ADORA1 0.0129
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0128
29 Tubulin beta-1 chain TUBB1 0.0127
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0125
1757 Myeloperoxidase MPO 0.0124
4120 NADPH--cytochrome P450 reductase POR 0.0124
1178 Adenosine A2a receptor ADORA2A 0.0123
1656 CYP2B protein CYP2B 0.0123
6014 Cytochrome P450 2A13 CYP2A13 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
1256 5-hydroxytryptamine 6 receptor HTR6 0.012
161 Tubulin beta chain TUBB 0.0119
312 Tubulin beta chain TUB2 0.0119
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0118
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0117
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0117
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0116
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0116
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
952 Dipeptidyl peptidase 4 DPP4 0.0114
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0114
474 Acetylcholinesterase ACHE 0.0113
869 Estrogen receptor beta ESR2 0.0113
6020 Aldehyde oxidase AOX1 0.0112
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0108
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0107
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0105
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0104
295 Carbonic anhydrase 1 CA1 0.0102
273 Apoptosis regulator Bcl-2 BCL2 0.0101
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0101
4122 Histone deacetylase 2 HDAC2 0.0101
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0101
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
528 5-hydroxytryptamine 1E receptor HTR1E 0.0097
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
373 Transthyretin TTR 0.0097
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0097
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0096
49 Endothelin B receptor EDNRB 0.0096
2539 Tubulin alpha-1 chain TUBA4A 0.0095
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0094
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0094
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0092
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0091
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0091
578 Endothelin-1 receptor EDNRA 0.009
275 Arachidonate 5-lipoxygenase ALOX5 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0087
1050 Bile salt sulfotransferase SULT2A1 0.0087
3947 Xanthine dehydrogenase/oxidase XDH 0.0087
738 Monocarboxylate transporter 1 SLC16A1 0.0087
4203 Histamine N-methyltransferase HNMT 0.0086
165 FL cytokine receptor FLT3 0.0086
2112 Toll-like receptor 9 TLR9 0.0086
921 Glutamate receptor 2 GRIA2 0.0086
705 Glutamate receptor 1 GRIA1 0.0085
814 Ryanodine receptor 1 RYR1 0.0084
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
6085 Fatty acid-binding protein, intestinal FABP2 0.008
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.008
5300 Antigen peptide transporter 1 TAP1 0.008
1196 Complement decay-accelerating factor CD55 0.008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.008
823 Fibroblast growth factor receptor 2 FGFR2 0.0079
88 Retinoic acid receptor RXR-beta RXRB 0.0079
173 Toll-like receptor 7 TLR7 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0077
6044 Serum paraoxonase/lactonase 3 PON3 0.0076
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0076
131 Synaptic vesicular amine transporter SLC18A2 0.0076
469 Annexin A1 ANXA1 0.0075
1618 High affinity nerve growth factor receptor NTRK1 0.0075
4311 tRNA TRDMT1 0.0074
4325 tRNA trmD 0.0074
4328 tRNA trmD 0.0074
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0074
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0074
1541 Metalloproteinase mmp20 0.0074
3810 Catechol O-methyltransferase COMT 0.0074
1517 Beta-3 adrenergic receptor ADRB3 0.0074
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0074
239 Coagulation factor X F10 0.0073
284 DNA-directed RNA polymerase beta chain rpoB 0.0073
5773 DNA-directed RNA polymerase beta chain rpoB 0.0073
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0072
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
518 Peroxidase/catalase T katG 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0069
1629 Transcription factor AP-1 JUN 0.0068
3086 Plasmepsin-2 Not Available 0.0068
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0068
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0068
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
1483 Membrane copper amine oxidase AOC3 0.0067
84 Nuclear receptor 0B1 NR0B1 0.0067
976 Platelet glycoprotein IX GP9 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0067
174 Sigma 1-type opioid receptor SIGMAR1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
1852 Microtubule-associated protein 2 MAP2 0.0065
54 Prothrombin F2 0.0065
4238 50S ribosomal protein L4 rplD 0.0065
5578 50S ribosomal protein L4 rplD 0.0065
6173 50S ribosomal protein L4 rplD 0.0065
6219 50S ribosomal protein L4 rplD 0.0065
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
780 Retinoic acid receptor RXR-gamma RXRG 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
1192 Sulfotransferase 1A1 SULT1A1 0.0063
133 Dihydropterate synthase sulI 0.0063
319 Opioid receptor, sigma 1 OPRS1 0.0063
2810 Dr hemagglutinin structural subunit draA 0.0062
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
482 Glycine receptor subunit alpha-1 GLRA1 0.0062
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0061
6174 50S ribosomal protein L32 rpmF 0.0061
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
856 Vitamin D3 receptor VDR 0.006
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
1630 Integrin beta-2 ITGB2 0.006
6126 Carbonic anhydrase 7 CA7 0.006
24 Thymidylate synthase TMP1 0.0059
359 Thymidylate synthase TYMS 0.0059
2626 Thymidylate synthase thyA 0.0059
2729 Thymidylate synthase thyA 0.0059
5352 Thymidylate synthase THYA 0.0059
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0058
5880 Thrombopoietin receptor MPL 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
6432 Transporter snf 0.0057
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0057
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0056
1275 Estrogen sulfotransferase SULT1E1 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
3932 Glutathione S-transferase A2 GSTA2 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
162 Retinoic acid receptor gamma-1 RARG 0.0053
33 Cystine/glutamate transporter SLC7A11 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0052
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
581 Cytochrome P450 2R1 CYP2R1 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.005
904 Glutathione S-transferase P GSTP1 0.005
4773 Deoxycytidine kinase DCK 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0049
6146 High affinity copper uptake protein 1 SLC31A1 0.0049
563 Thyroid peroxidase TPO 0.0048
3809 Estrogen-related receptor gamma ESRRG 0.0048
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0048
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0048
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0045
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0045
572 Integrin alpha-L ITGAL 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
5934 Cytochrome P450 26A1 CYP26A1 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
5787 Angiopoietin-1 receptor TEK 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1864 RET proto-oncogene RET 0.0042
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0042
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0042
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
564 Cellular retinoic acid-binding protein 1 CRABP1 0.004
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
164 Histamine H4 receptor HRH4 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1992 Vitamin D-binding protein GC 0.0038
4192 DNA topoisomerase 2-beta TOP2B 0.0038
3957 Adenosine deaminase ADA 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
85 Growth hormone receptor GHR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
7 Nitric oxide synthase, inducible NOS2 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0036
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6221 Steroid hormone receptor ERR1 ESRRA 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0035
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0034
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
537 ATP synthase delta chain, mitochondrial ATP5D 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2981 Phospholipase A2, membrane associated PLA2G2A 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
1039 Histone deacetylase 9 HDAC9 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3937 Fatty-acid amide hydrolase FAAH 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
908 Glutathione S-transferase theta-1 GSTT1 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
4217 Telomerase reverse transcriptase TERT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
1341 Histamine H3 receptor HRH3 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
3404 Exotoxin A eta 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
444 Alcohol dehydrogenase 1B ADH1B 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2021 Thrombomodulin THBD 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.002
1820 Beta-nerve growth factor NGF 0.002
6218 Pannexin-1 PANX1 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
517 Alcohol dehydrogenase 1C ADH1C 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
291 Nitric-oxide synthase, endothelial NOS3 0.0016
1243 Cathepsin D CTSD 0.0016
2207 Rhodopsin RHO 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2132 Protein S100-B S100B 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3221 Cytochrome c4 cc4 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
1507 Cytochrome c CYCS 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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