DT-Web: DB00849

Identification

Name

Methylphenobarbital

Accession Number

DB00849 (APRD00047)

Type

small molecule

Description

A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

246.2619

Groups

approved

Monoisotopic Weight

246.100442324

Pharmacology

Indication

For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy.

Mechanism of action

Methylphenobarbital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Absorption

Approximately 50% of an oral dose of mephobarbital is absorbed from the gastrointestinal tract.

Protein binding

70-76%

Biotransformation

Hepatic, primarily by the hepatic microsomal enzyme system. About 75% of a single oral dose of mephobarbital is metabolized to phenobarbital in 24 hours.

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Aminophylline	The barbiturate, methylphenobarbital, decreases the effect of aminophylline.
Betamethasone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, betamethasone.
Clomifene	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, clomifene.
Conjugated Estrogens	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Cyclosporine	The barbiturate, methylphenobarbital, increases the effect of cyclosporine.
Delavirdine	The anticonvulsant, methylphenobarbital, decreases the effect of delavirdine.
Dexamethasone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, dexamethasone.
Diethylstilbestrol	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, diethylstilbestrol.
Doxycycline	The anticonvulsant, methylphenobarbital, decreases the effect of doxycycline.
Estradiol	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, estradiol.
Ethinyl Estradiol	This product may cause a slight decrease of contraceptive effect
Felodipine	The barbiturate, methylphenobarbital, decreases the effect of felodipine.
Fludrocortisone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Folic Acid	Folic acid decreases the effect of anticonvulsant, methylphenobarbital.
Gefitinib	The CYP3A4 inducer, methylphenobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Griseofulvin	The barbiturate, methylphenobarbital, decreases the effect of griseofulvin.
Hydrocortisone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Levonorgestrel	Phenobarbital decreases the effect of levonorgestrel
Medroxyprogesterone	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, medroxyprogesterone.
Megestrol	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, megestrol.
Methadone	The barbiturate, methylphenobarbital, decreases the effect of methadone.
Metronidazole	The barbiturate, methylphenobarbital, decreases the effect of metronidazole.
Nifedipine	The barbiturate, methylphenobarbital, decreases the effect of the calcium channel blocker, nifedipine.
Norethindrone	This product may cause a slight decrease of contraceptive effect
Oxtriphylline	The barbiturate, methylphenobarbital, decreases the effect of oxtriphylline.
Prednisolone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, prednisolone.
Prednisone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, prednisone.
Quinidine	The anticonvulsant, methylphenobarbital, decreases the effect of quinidine.
Theophylline	The barbiturate, methylphenobarbital, decreases the effect of theophylline.
Triamcinolone	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, triamcinolone.
Verapamil	Methylphenobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Methylphenobarbital is initiated, discontinued or dose changed.

Food Interactions

Not Available

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. - Pubmed Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed Roden WH, Peugh LD, Jansen LA: Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex. Neurosci Lett. 2010 Oct 15;483(3):167-72. Epub 2010 Aug 6. - Pubmed
DTHybrid score	0.8529
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed
DTHybrid score	0.7958
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed
DTHybrid score	0.7838
Gamma-aminobutyric-acid receptor subunit alpha-4
Name	Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name	GABRA4
Pharmacological action	yes
Actions	potentiator
References	Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed
DTHybrid score	0.7435
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed
DTHybrid score	0.7932
Gamma-aminobutyric-acid receptor subunit alpha-6
Name	Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name	GABRA6
Pharmacological action	yes
Actions	potentiator
References	Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Olsen RW, Li GD: GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation. Can J Anaesth. 2010 Dec 31. - Pubmed
DTHybrid score	0.7438
Neuronal acetylcholine receptor subunit alpha-4
Name	Neuronal acetylcholine receptor subunit alpha-4
Gene Name	CHRNA4
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score	0.6961
Neuronal acetylcholine receptor subunit alpha-7
Name	Neuronal acetylcholine receptor subunit alpha-7
Gene Name	CHRNA7
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score	0.6962
Glutamate receptor 2
Name	Glutamate receptor 2
Gene Name	GRIA2
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score	1.3104
Glutamate receptor, ionotropic kainate 2
Name	Glutamate receptor, ionotropic kainate 2
Gene Name	GRIK2
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score	0.8405

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3391
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2827

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2978
4757	Cytochrome P450 2C9	CYP2C9	0.2337
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.1942
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.1873
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.1863
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.1829
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.1743
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.1734
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.1732
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.173
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.1728
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.1728
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.1725
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.1723
6013	Cytochrome P450 2E1	CYP2E1	0.1657
4200	Cytochrome P450 1A2	CYP1A2	0.1623
4924	Cytochrome P450 2C8	CYP2C8	0.1485
4119	Cytochrome P450 2D6	CYP2D6	0.1272
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.1264
811	Translocator protein	TSPO	0.1064
1588	Multidrug resistance protein 1	ABCB1	0.1038
5718	Cytochrome P450 2A6	CYP2A6	0.0974
4118	Cytochrome P450 3A5	CYP3A5	0.0938
6107	Cytochrome P450 3A7	CYP3A7	0.0792
20	Prostaglandin G/H synthase 1	PTGS1	0.065
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0576
6106	Cytochrome P450 2C18	CYP2C18	0.0556
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0498
6024	Cytochrome P450 1A1	CYP1A1	0.0466
587	Serum albumin	ALB	0.0425
3937	Fatty-acid amide hydrolase	FAAH	0.0387
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0328
468	Cytochrome P450 4A11	CYP4A11	0.0269
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0266
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0262
172	Potassium channel subfamily K member 1	KCNK1	0.0247
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0232
482	Glycine receptor subunit alpha-1	GLRA1	0.0229
824	Sodium-dependent serotonin transporter	SLC6A4	0.0225
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0221
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0217
862	Multidrug resistance-associated protein 1	ABCC1	0.0215
6144	Solute carrier family 22 member 2	SLC22A2	0.0206
1898	Cytochrome P450 1B1	CYP1B1	0.0204
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0202
492	Histamine H1 receptor	HRH1	0.02
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0197
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0196
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0187
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0187
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0187
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0187
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0185
3811	Cytochrome P450 19A1	CYP19A1	0.0185
776	Bile salt export pump	ABCB11	0.0184
6145	Solute carrier family 22 member 1	SLC22A1	0.0182
705	Glutamate receptor 1	GRIA1	0.0182
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0177
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0176
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0175
831	D(2) dopamine receptor	DRD2	0.0172
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0169
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0167
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0166
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0166
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0166
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0161
923	Glutamate receptor 3	GRIA3	0.0159
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0158
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
556	Alpha-1A adrenergic receptor	ADRA1A	0.0146
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0146
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0142
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0141
6031	Cytochrome P450 3A43	CYP3A43	0.0138
260	Cytochrome P450 51	ERG11	0.0136
761	Cytochrome P450 51	ERG11	0.0136
3163	Cytochrome P450 51	cyp51	0.0136
713	Sodium-dependent dopamine transporter	SLC6A3	0.0136
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0131
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0121
731	HIV-1 protease	HIV-1 protease	0.0121
3941	Amine oxidase [flavin-containing] A	MAOA	0.0121
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0117
3923	Cholinesterase	BCHE	0.0116
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0113
318	Alpha-2A adrenergic receptor	ADRA2A	0.0112
3426	Glutamine synthetase	glnA	0.0111
3987	Glutamine synthetase	GLUL	0.0111
465	Calmodulin	CALM1	0.0108
3939	Amine oxidase [flavin-containing] B	MAOB	0.0104
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0101
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0099
23	D(1A) dopamine receptor	DRD1	0.0098
122	P2Y purinoceptor 12	P2RY12	0.0098
6102	Arylamine N-acetyltransferase 2	NAT2	0.0097
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0097
1729	Solute carrier family 22 member 6	SLC22A6	0.0096
6147	Solute carrier family 22 member 3	SLC22A3	0.0093
118	Organic cation/carnitine transporter 2	SLC22A5	0.0092
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.009
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0088
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0086
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0086
6014	Cytochrome P450 2A13	CYP2A13	0.0083
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0083
820	Glycine receptor subunit alpha-2	GLRA2	0.0082
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0081
833	Organic cation/carnitine transporter 1	SLC22A4	0.0079
290	Prostaglandin G/H synthase 2	PTGS2	0.0078
146	Androgen receptor	AR	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
174	Sigma 1-type opioid receptor	SIGMAR1	0.0078
6142	Solute carrier family 22 member 8	SLC22A8	0.0076
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0076
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0075
136	Estrogen receptor	ESR1	0.0073
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0071
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
4120	NADPH--cytochrome P450 reductase	POR	0.0069
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0066
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0066
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0065
766	Beta-2 adrenergic receptor	ADRB2	0.0064
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0064
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0062
847	Mu-type opioid receptor	OPRM1	0.0062
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0061
632	Alpha-1B adrenergic receptor	ADRA1B	0.0061
6020	Aldehyde oxidase	AOX1	0.0059
474	Acetylcholinesterase	ACHE	0.0058
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0058
2164	Multidrug resistance-associated protein 4	ABCC4	0.0058
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0055
696	Kappa-type opioid receptor	OPRK1	0.0055
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0054
124	Histamine H2 receptor	HRH2	0.0054
592	Carbonic anhydrase 4	CA4	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0053
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0053
6220	Aryl hydrocarbon receptor	AHR	0.0053
1656	CYP2B protein	CYP2B	0.0053
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0052
6143	Solute carrier family 22 member 7	SLC22A7	0.0052
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0052
467	Delta-type opioid receptor	OPRD1	0.0051
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.005
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0049
6136	Multidrug resistance-associated protein 5	ABCC5	0.0048
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0046
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0046
629	Alpha-2B adrenergic receptor	ADRA2B	0.0046
818	50S ribosomal protein L10	rplJ	0.0045
461	Glycine receptor subunit alpha-3	GLRA3	0.0045
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0045
6182	Cytochrome P450 2J2	CYP2J2	0.0044
6137	Multidrug resistance-associated protein 6	ABCC6	0.0044
789	Alpha-1D adrenergic receptor	ADRA1D	0.0043
1010	Cytochrome P450 51A1	CYP51A1	0.0043
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0043
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0042
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0042
891	Dihydropteroate synthase	folP	0.0042
5359	Dihydropteroate synthase	folP	0.0042
7175	Dihydropteroate synthase	sulI	0.0042
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0042
504	Mast/stem cell growth factor receptor	KIT	0.0041
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0041
193	Beta-1 adrenergic receptor	ADRB1	0.0041
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0041
756	Sex hormone-binding globulin	SHBG	0.0041
4604	Liver carboxylesterase 1	CES1	0.004
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.004
427	Substance-P receptor	TACR1	0.0039
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0039
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0038
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0038
251	Alcohol dehydrogenase 1A	ADH1A	0.0038
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0038
26	Vascular endothelial growth factor receptor 3	FLT4	0.0037
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0036
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0036
32	Vascular endothelial growth factor receptor 1	FLT1	0.0036
1757	Myeloperoxidase	MPO	0.0035
161	Tubulin beta chain	TUBB	0.0035
312	Tubulin beta chain	TUB2	0.0035
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0035
638	D(3) dopamine receptor	DRD3	0.0034
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0034
444	Alcohol dehydrogenase 1B	ADH1B	0.0034
844	Epidermal growth factor receptor	EGFR	0.0033
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0033
817	DNA topoisomerase 2-alpha	TOP2A	0.0032
362	Melatonin receptor type 1B	MTNR1B	0.0032
571	Melatonin receptor type 1A	MTNR1A	0.0032
563	Thyroid peroxidase	TPO	0.0031
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.003
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0029
869	Estrogen receptor beta	ESR2	0.0029
517	Alcohol dehydrogenase 1C	ADH1C	0.0029
407	Vascular endothelial growth factor receptor 2	KDR	0.0029
6432	Transporter	snf	0.0028
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0028
716	5-hydroxytryptamine 7 receptor	HTR7	0.0028
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0028
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0028
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0028
1618	High affinity nerve growth factor receptor	NTRK1	0.0027
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0027
49	Endothelin B receptor	EDNRB	0.0027
777	Tumor necrosis factor	TNF	0.0026
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0026
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0026
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0026
85	Growth hormone receptor	GHR	0.0025
373	Transthyretin	TTR	0.0025
578	Endothelin-1 receptor	EDNRA	0.0025
581	Cytochrome P450 2R1	CYP2R1	0.0025
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0024
1024	Solute carrier family 22 member 11	SLC22A11	0.0024
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0024
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0024
1268	Neuropeptide S receptor	NPSR1	0.0024
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0024
735	Alanine aminotransferase 1	GPT	0.0024
3904	Alanine aminotransferase 2	GPT2	0.0024
380	Cytochrome P450 17A1	CYP17A1	0.0024
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0024
6148	Multidrug resistance-associated protein 7	ABCC10	0.0023
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0023
183	Vascular endothelial growth factor A	VEGFA	0.0023
1992	Vitamin D-binding protein	GC	0.0023
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0023
738	Monocarboxylate transporter 1	SLC16A1	0.0023
823	Fibroblast growth factor receptor 2	FGFR2	0.0023
922	Glutamate receptor 4	GRIA4	0.0023
6141	Sodium/bile acid cotransporter	SLC10A1	0.0023
319	Opioid receptor, sigma 1	OPRS1	0.0023
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0023
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0022
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0022
4027	Glutamate receptor delta-1 subunit	GRID1	0.0022
4018	Glutamate receptor delta-2 subunit	GRID2	0.0022
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0022
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0022
1912	Excitatory amino acid transporter 1	SLC1A3	0.0022
664	Glutamate decarboxylase 2	GAD2	0.0022
3890	Glutamate decarboxylase 2	GAD2	0.0022
4016	Excitatory amino acid transporter 5	SLC1A7	0.0022
4019	Excitatory amino acid transporter 4	SLC1A6	0.0022
1047	Excitatory amino acid transporter 2	SLC1A2	0.0022
4026	Aspartyl aminopeptidase	DNPEP	0.0022
6073	Potassium channel subfamily K member 9	KCNK9	0.0022
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0022
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0022
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0022
6072	Potassium channel subfamily K member 3	KCNK3	0.0022
925	Metabotropic glutamate receptor 4	GRM4	0.0022
926	Metabotropic glutamate receptor 7	GRM7	0.0022
927	Metabotropic glutamate receptor 8	GRM8	0.0022
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0022
2539	Tubulin alpha-1 chain	TUBA4A	0.0022
4020	Glutamyl aminopeptidase	ENPEP	0.0022
4017	5-oxoprolinase	OPLAH	0.0022
84	Nuclear receptor 0B1	NR0B1	0.0022
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0022
6085	Fatty acid-binding protein, intestinal	FABP2	0.0022
70	Type-1 angiotensin II receptor	AGTR1	0.0022
33	Cystine/glutamate transporter	SLC7A11	0.0022
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0022
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0022
1630	Integrin beta-2	ITGB2	0.0021
131	Synaptic vesicular amine transporter	SLC18A2	0.0021
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0021
7	Nitric oxide synthase, inducible	NOS2	0.0021
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
94	5-hydroxytryptamine 4 receptor	HTR4	0.002
625	Glutamate carboxypeptidase 2	FOLH1	0.002
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.002
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.002
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.002
3932	Glutathione S-transferase A2	GSTA2	0.0019
6138	Multidrug resistance protein 3	ABCB4	0.0019
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0019
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0019
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0019
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0019
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0019
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0019
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0019
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0019
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0019
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0019
665	Phosphoserine aminotransferase	PSAT1	0.0019
4652	Phosphoserine aminotransferase	serC	0.0019
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0019
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0019
420	Glutamate decarboxylase 1	GAD1	0.0019
3900	Glutamate decarboxylase 1	GAD1	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0018
1253	Interferon gamma	IFNG	0.0018
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0018
916	Metabotropic glutamate receptor 1	GRM1	0.0018
1671	Excitatory amino acid transporter 3	SLC1A1	0.0017
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0017
856	Vitamin D3 receptor	VDR	0.0017
1262	Corticotropin-lipotropin	POMC	0.0017
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0017
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0017
3877	Growth-inhibiting protein 18	GIG18	0.0017
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0017
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0017
295	Carbonic anhydrase 1	CA1	0.0017
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0017
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0017
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0017
871	Glucocorticoid receptor	NR3C1	0.0017
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0017
763	Tyrosine aminotransferase	TAT	0.0016
5493	Tyrosine aminotransferase	Not Available	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
633	Penicillin-binding proteins 1A/1B	pbpA	0.0016
2207	Rhodopsin	RHO	0.0016
267	Plasminogen activator inhibitor 1	SERPINE1	0.0016
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0016
432	D(4) dopamine receptor	DRD4	0.0016
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0016
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0016
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0015
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0015
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0015
6146	High affinity copper uptake protein 1	SLC31A1	0.0015
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0015
518	Peroxidase/catalase T	katG	0.0015
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0015
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0015
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0015
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0015
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0015
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0015
29	Tubulin beta-1 chain	TUBB1	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0014
614	Progesterone receptor	PGR	0.0014
1039	Histone deacetylase 9	HDAC9	0.0014
65	Matrix metalloproteinase-9	Not Available	0.0014
6126	Carbonic anhydrase 7	CA7	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0014
4311	tRNA	TRDMT1	0.0013
4325	tRNA	trmD	0.0013
4328	tRNA	trmD	0.0013
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0013
106	Cannabinoid receptor 2	CNR2	0.0013
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0013
6174	50S ribosomal protein L32	rpmF	0.0013
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0013
4238	50S ribosomal protein L4	rplD	0.0013
5578	50S ribosomal protein L4	rplD	0.0013
6173	50S ribosomal protein L4	rplD	0.0013
6219	50S ribosomal protein L4	rplD	0.0013
1196	Complement decay-accelerating factor	CD55	0.0013
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0013
291	Nitric-oxide synthase, endothelial	NOS3	0.0013
936	Ephrin type-A receptor 2	EPHA2	0.0013
165	FL cytokine receptor	FLT3	0.0012
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0012
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
68	Cannabinoid receptor 1	CNR1	0.0012
5787	Angiopoietin-1 receptor	TEK	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
1192	Sulfotransferase 1A1	SULT1A1	0.0012
904	Glutathione S-transferase P	GSTP1	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0012
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0012
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0012
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0012
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
634	Squalene monooxygenase	SQLE	0.0012
7196	Squalene monooxygenase	ERG1	0.0012
3809	Estrogen-related receptor gamma	ESRRG	0.0011
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0011
469	Annexin A1	ANXA1	0.0011
2808	Chloramphenicol acetyltransferase 3	cat3	0.0011
719	Retinoic acid receptor responder protein 1	RARRES1	0.0011
770	Retinoic acid-induced protein 3	GPRC5A	0.0011
6151	Monocarboxylate transporter 10	SLC16A10	0.0011
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0011
284	DNA-directed RNA polymerase beta chain	rpoB	0.0011
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0011
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0011
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0011
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.001
3601	Dihydropteroate synthase 1	folP1	0.001
3807	Dihydropteroate synthase 1	folP1	0.001
3808	Dihydropteroate synthase 2	folP2	0.001
2417	Chloramphenicol acetyltransferase	cat	0.001
3278	Chloramphenicol acetyltransferase	cat	0.001
3947	Xanthine dehydrogenase/oxidase	XDH	0.001
2810	Dr hemagglutinin structural subunit	draA	0.001
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.001
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.001
365	Dihydrofolate reductase	DHFR	0.001
2381	Dihydrofolate reductase	DFR1	0.001
2833	Dihydrofolate reductase	Not Available	0.001
2931	Dihydrofolate reductase	folA	0.001
3544	Dihydrofolate reductase	folA	0.001
3682	Dihydrofolate reductase	folA	0.001
6642	Dihydrofolate reductase	folA	0.001
6756	Dihydrofolate reductase	dfrA	0.001
1353	DNA topoisomerase 1	TOP1	0.001
3552	DNA topoisomerase 1	topA	0.001
163	D(1B) dopamine receptor	DRD5	0.001
569	Retinal dehydrogenase 2	ALDH1A2	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.001
275	Arachidonate 5-lipoxygenase	ALOX5	0.001
378	Alpha-2C adrenergic receptor	ADRA2C	0.001
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.001
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0009
3830	Calreticulin	CALR	0.0009
611	Retinal dehydrogenase 1	ALDH1A1	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0009
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0009
976	Platelet glycoprotein IX	GP9	0.0009
751	Potassium channel subfamily K member 6	KCNK6	0.0008
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0008
4102	Proteasome subunit beta type 5	PSMB5	0.0008
4101	Proteasome subunit beta type 1	PSMB1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
952	Dipeptidyl peptidase 4	DPP4	0.0008
4217	Telomerase reverse transcriptase	TERT	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0008
239	Coagulation factor X	F10	0.0008
6163	Copper-transporting ATPase 2	ATP7B	0.0008
6165	Copper-transporting ATPase 1	ATP7A	0.0008
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0007
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0007
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0007
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
6168	Solute carrier family 22 member 16	SLC22A16	0.0007
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0007
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0007
908	Glutathione S-transferase theta-1	GSTT1	0.0007
6044	Serum paraoxonase/lactonase 3	PON3	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
2021	Thrombomodulin	THBD	0.0007
1517	Beta-3 adrenergic receptor	ADRB3	0.0007
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0007
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0006
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0006
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0006
572	Integrin alpha-L	ITGAL	0.0006
896	Glutathione S-transferase Mu 1	GSTM1	0.0006
2320	Thymidine kinase, cytosolic	TK1	0.0006
1864	RET proto-oncogene	RET	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
4122	Histone deacetylase 2	HDAC2	0.0006
153	Dopamine beta-hydroxylase	DBH	0.0006
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0006
6218	Pannexin-1	PANX1	0.0006
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0006
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0005
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0005
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0005
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0005
6042	Prostaglandin reductase 2	PTGR2	0.0005
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
3810	Catechol O-methyltransferase	COMT	0.0005
1792	Tissue-type plasminogen activator	PLAT	0.0005
273	Apoptosis regulator Bcl-2	BCL2	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
6043	Putative G-protein coupled receptor 44	GPR44	0.0005
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0005
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
737	Mineralocorticoid receptor	NR3C2	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0004
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0004
6131	Carbonic anhydrase 14	CA14	0.0004
1313	Lactoylglutathione lyase	GLO1	0.0004
6122	Carbonic anhydrase 3	CA3	0.0004
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0004
489	Monocarboxylate transporter 2	SLC16A7	0.0003
3007	Carbonic anhydrase 12	CA12	0.0003
4205	Carbonic anhydrase 9	CA9	0.0003
164	Histamine H4 receptor	HRH4	0.0003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4984	Neuroglobin	NGB	0.0003
4943	Cytochrome c6	petJ	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4910	Cytoglobin	CYGB	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4909	CooA protein	cooA	0.0003
5000	HemO	hemO	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4972	P450cin	cinA	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
3093	Catalase HPII	katE	0.0003
4952	Catalase/peroxidase	katA	0.0003
4920	Peroxidase/catalase	katG	0.0002
4948	Cytochrome c-553	Not Available	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
2119	Cytochrome b5	CYB5A	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4990	PpcA	ppcA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
605	Fumarate reductase flavoprotein subunit	frdA	0.0002
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0002
3673	Fumarate reductase flavoprotein subunit	fccA	0.0002
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0002
6549	Fumarate reductase flavoprotein subunit	frdA	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00849 - Methylphenobarbital

Targets

Enzymes

Predictions