DT-Web

DB00741 - Hydrocortisone


Identification
Name Hydrocortisone
Accession Number DB00741 (APRD01019)
Type small molecule
Description The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 362.4599
Groups approved
Monoisotopic Weight 362.20932407
Pharmacology
Indication For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Mechanism of action Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Absorption Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
Protein binding 95%
Biotransformation Primarily hepatic via CYP3A4
Route of elimination Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Toxicity Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The corticosteroid, hydrocortisone, alters the anticoagulant effect, acenocoumarol.
Acetylsalicylic acid The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Ambenonium The corticosteroid, hydrocortisone, may decrease the effect of the anticholinesterase, ambenonium.
Amobarbital The barbiturate, amobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Anisindione The corticosteroid, hydrocortisone, alters the anticoagulant effect of anisindione.
Aprobarbital The barbiturate, aprobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Bismuth Subsalicylate The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
Butabarbital The barbiturate, butabarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Butalbital The barbiturate, butalbital, may decrease the effect of the corticosteroid, hydrocortisone.
Butethal The barbiturate, butethal, may decrease the effect of the corticosteroid, hydrocortisone.
Cholestyramine Cholestyramine may decrease the effect of hydrocortisone.
Colestipol Cholestyramine decreases the effect of hydrocortisone
Dicumarol The corticosteroid, hydrocortisone, alters the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, hydrocortisone.
Edrophonium The corticosteroid, hydrocortisone, may decrease the effect of the anticholinesterase, edrophonium.
Ethotoin The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, hydrocortisone.
Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Heptabarbital The barbiturate, heptabarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Hexobarbital The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Indacaterol Concomitant therapy may increase the risk of hypokalemia via intracellular shunting. Monitor for adverse effects and especially for cardiovascular effects associated with hypokalemia.
Linagliptin CYP3A4 inducers may decrease levels of linagliptin and diminish the hypoglycemic effect of antidiabetic agents. Monitor concomitant therapy closely.
Magnesium salicylate The corticosteroid, hydrocortisone, may decrease the effect of magnesium salicylate.
Mephenytoin The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Methohexital The barbiturate, methohexital, may decrease the effect of the corticosteroid, hydrocortisone.
Methylphenobarbital The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Midodrine Increased arterial pressure
Neostigmine The corticosteroid, hydrocortisone, may decrease the effect of the anticholinesterase, neostigmine.
Pentobarbital The barbiturate, pentobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Phenobarbital The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Phenytoin The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Primidone The barbiturate, primidone, may decrease the effect of the corticosteroid, hydrocortisone.
Pyridostigmine The corticosteroid, hydrocortisone, may decrease the effect of the anticholinesterase, pyridostigmine.
Quinidine barbiturate The barbiturate, quinidine barbiturate, may decrease the effect of the corticosteroid, hydrocortisone.
Rifampin The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, hydrocortisone.
Salicylate-sodium The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, salicylate-sodium.
Salsalate The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, salsalate.
Secobarbital The barbiturate, secobarbital, may decrease the effect of the corticosteroid, hydrocortisone.
Tacrine Tacrine and Hydrocortisone may independently exacerbate muscle weakness in myasthenia gravis patients. Monitor for additive muscle weakness effects.
Talbutal The barbiturate, talbutal, may decrease the effect of the corticosteroid, hydrocortisone.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trisalicylate-choline The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
Vecuronium Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Hydrocortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Warfarin The corticosteroid, hydrocortisone, alters the anticoagulant effect of warfarin.
Food Interactions
  • Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use.

Targets


Glucocorticoid receptor
Name Glucocorticoid receptor
Gene Name NR3C1
Pharmacological action yes
Actions agonist
References
  • Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. - Pubmed
  • Rautanen A, Eriksson JG, Kere J, Andersson S, Osmond C, Tienari P, Sairanen H, Barker DJ, Phillips DI, Forsen T, Kajantie E: Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. J Clin Endocrinol Metab. 2006 Nov;91(11):4544-51. Epub 2006 Aug 8. - Pubmed
  • Hammer F, Stewart PM: Cortisol metabolism in hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):337-53. - Pubmed
  • Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA: Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1052-60. Epub 2006 Oct 12. - Pubmed
  • Sher L: Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. ScientificWorldJournal. 2006 Oct 31;6:1398-404. - Pubmed
DTHybrid score 1.0499
Annexin A1
Name Annexin A1
Gene Name ANXA1
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res. 2000 Oct;292(10):496-9. - Pubmed
  • White MV, Igarashi Y, Lundgren JD, Shelhamer J, Kaliner M: Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. J Immunol. 1991 Jul 15;147(2):667-73. - Pubmed
  • Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. Arch Dermatol Res. 1994;286(5):268-72. - Pubmed
DTHybrid score 0.4718

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score 0.7987
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.5023
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.4132
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3683
Cytochrome P450 11B2, mitochondrial
Name Cytochrome P450 11B2, mitochondrial
Gene Name CYP11B2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3439
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.376

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed
  • Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. - Pubmed
  • Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. - Pubmed
  • Orlowski S, Mir LM, Belehradek J Jr, Garrigos M: Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996 Jul 15;317 ( Pt 2):515-22. - Pubmed
DTHybrid score 0.6068
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed
DTHybrid score 0.2975
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. - Pubmed
  • Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed
DTHybrid score 0.3196

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6068
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.2975
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.3196

Predictions


Id Partner name Gene Name Score
232 Corticosteroid-binding globulin SERPINA6 0.302
4757 Cytochrome P450 2C9 CYP2C9 0.298
4119 Cytochrome P450 2D6 CYP2D6 0.2918
6016 Cytochrome P450 2C19 CYP2C19 0.2657
4200 Cytochrome P450 1A2 CYP1A2 0.2217
6030 Cytochrome P450 2B6 CYP2B6 0.1644
3811 Cytochrome P450 19A1 CYP19A1 0.1514
587 Serum albumin ALB 0.1372
6013 Cytochrome P450 2E1 CYP2E1 0.1357
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1332
6024 Cytochrome P450 1A1 CYP1A1 0.1292
737 Mineralocorticoid receptor NR3C2 0.1236
146 Androgen receptor AR 0.1232
380 Cytochrome P450 17A1 CYP17A1 0.1201
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1187
5718 Cytochrome P450 2A6 CYP2A6 0.1118
862 Multidrug resistance-associated protein 1 ABCC1 0.0993
776 Bile salt export pump ABCB11 0.0857
136 Estrogen receptor ESR1 0.0803
869 Estrogen receptor beta ESR2 0.0766
6145 Solute carrier family 22 member 1 SLC22A1 0.0717
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0717
1898 Cytochrome P450 1B1 CYP1B1 0.0707
269 Adrenodoxin, mitochondrial FDX1 0.0706
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0692
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.069
614 Progesterone receptor PGR 0.0682
6142 Solute carrier family 22 member 8 SLC22A8 0.065
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0625
1729 Solute carrier family 22 member 6 SLC22A6 0.0595
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0583
20 Prostaglandin G/H synthase 1 PTGS1 0.0573
6106 Cytochrome P450 2C18 CYP2C18 0.0553
118 Organic cation/carnitine transporter 2 SLC22A5 0.0543
6031 Cytochrome P450 3A43 CYP3A43 0.0539
831 D(2) dopamine receptor DRD2 0.0529
6143 Solute carrier family 22 member 7 SLC22A7 0.0514
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0497
381 Prolactin receptor PRLR 0.0488
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0487
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0471
6141 Sodium/bile acid cotransporter SLC10A1 0.0467
94 5-hydroxytryptamine 4 receptor HTR4 0.046
260 Cytochrome P450 51 ERG11 0.0454
761 Cytochrome P450 51 ERG11 0.0454
3163 Cytochrome P450 51 cyp51 0.0454
6144 Solute carrier family 22 member 2 SLC22A2 0.0453
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0447
2164 Multidrug resistance-associated protein 4 ABCC4 0.0429
629 Alpha-2B adrenergic receptor ADRA2B 0.0422
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0418
847 Mu-type opioid receptor OPRM1 0.0418
492 Histamine H1 receptor HRH1 0.0404
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0385
290 Prostaglandin G/H synthase 2 PTGS2 0.0375
824 Sodium-dependent serotonin transporter SLC6A4 0.036
468 Cytochrome P450 4A11 CYP4A11 0.0356
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0354
6148 Multidrug resistance-associated protein 7 ABCC10 0.035
731 HIV-1 protease HIV-1 protease 0.0343
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0334
1024 Solute carrier family 22 member 11 SLC22A11 0.0333
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0332
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0326
2298 Cytochrome P450-cam camC 0.0326
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0325
6147 Solute carrier family 22 member 3 SLC22A3 0.0324
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0319
467 Delta-type opioid receptor OPRD1 0.0319
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0314
320 5-hydroxytryptamine 1A receptor HTR1A 0.0307
556 Alpha-1A adrenergic receptor ADRA1A 0.0302
844 Epidermal growth factor receptor EGFR 0.0294
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0293
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0293
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0289
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0289
696 Kappa-type opioid receptor OPRK1 0.0289
502 5-hydroxytryptamine 2A receptor HTR2A 0.0288
84 Nuclear receptor 0B1 NR0B1 0.0286
33 Cystine/glutamate transporter SLC7A11 0.028
817 DNA topoisomerase 2-alpha TOP2A 0.0269
723 Cytosolic phospholipase A2 PLA2G4A 0.0266
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0262
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0261
6182 Cytochrome P450 2J2 CYP2J2 0.0258
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0249
833 Organic cation/carnitine transporter 1 SLC22A4 0.0245
504 Mast/stem cell growth factor receptor KIT 0.0245
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0243
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0242
4604 Liver carboxylesterase 1 CES1 0.0239
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0238
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0236
6137 Multidrug resistance-associated protein 6 ABCC6 0.0235
3923 Cholinesterase BCHE 0.0235
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0226
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0221
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0221
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0218
1353 DNA topoisomerase 1 TOP1 0.0215
3552 DNA topoisomerase 1 topA 0.0215
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0214
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0214
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0211
318 Alpha-2A adrenergic receptor ADRA2A 0.0206
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0206
341 5-hydroxytryptamine 3 receptor HTR3A 0.0203
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0203
632 Alpha-1B adrenergic receptor ADRA1B 0.0203
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0194
904 Glutathione S-transferase P GSTP1 0.0193
29 Tubulin beta-1 chain TUBB1 0.019
638 D(3) dopamine receptor DRD3 0.0188
766 Beta-2 adrenergic receptor ADRB2 0.0188
885 5-hydroxytryptamine 1B receptor HTR1B 0.0188
3941 Amine oxidase [flavin-containing] A MAOA 0.0187
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0186
228 Beta platelet-derived growth factor receptor PDGFRB 0.0184
238 Peroxisome proliferator-activated receptor gamma PPARG 0.018
23 D(1A) dopamine receptor DRD1 0.0179
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0177
244 Angiotensin-converting enzyme ACE 0.0176
1649 Small inducible cytokine A2 CCL2 0.0174
6136 Multidrug resistance-associated protein 5 ABCC5 0.0174
4120 NADPH--cytochrome P450 reductase POR 0.0172
26 Vascular endothelial growth factor receptor 3 FLT4 0.0172
725 5-hydroxytryptamine 1D receptor HTR1D 0.0171
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.017
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0169
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0169
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0168
590 5-hydroxytryptamine 2C receptor HTR2C 0.0168
407 Vascular endothelial growth factor receptor 2 KDR 0.0167
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0165
32 Vascular endothelial growth factor receptor 1 FLT1 0.0164
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0163
7 Nitric oxide synthase, inducible NOS2 0.0162
193 Beta-1 adrenergic receptor ADRB1 0.0161
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.016
713 Sodium-dependent dopamine transporter SLC6A3 0.0159
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0159
1010 Cytochrome P450 51A1 CYP51A1 0.0158
738 Monocarboxylate transporter 1 SLC16A1 0.0151
274 Muscarinic acetylcholine receptor M5 CHRM5 0.015
811 Translocator protein TSPO 0.015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0148
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0147
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0146
226 Gonadotropin-releasing hormone receptor GNRHR 0.0143
465 Calmodulin CALM1 0.0142
789 Alpha-1D adrenergic receptor ADRA1D 0.0139
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0137
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0135
2539 Tubulin alpha-1 chain TUBA4A 0.0135
3587 Gastrotropin FABP6 0.0134
952 Dipeptidyl peptidase 4 DPP4 0.0134
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0133
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
6085 Fatty acid-binding protein, intestinal FABP2 0.0128
70 Type-1 angiotensin II receptor AGTR1 0.0127
6220 Aryl hydrocarbon receptor AHR 0.0127
4237 50S ribosomal protein L22 rplV 0.0127
373 Transthyretin TTR 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
378 Alpha-2C adrenergic receptor ADRA2C 0.0123
4773 Deoxycytidine kinase DCK 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
818 50S ribosomal protein L10 rplJ 0.0122
161 Tubulin beta chain TUBB 0.0122
312 Tubulin beta chain TUB2 0.0122
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0121
124 Histamine H2 receptor HRH2 0.0121
165 FL cytokine receptor FLT3 0.0119
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0118
4238 50S ribosomal protein L4 rplD 0.0118
5578 50S ribosomal protein L4 rplD 0.0118
6173 50S ribosomal protein L4 rplD 0.0118
6219 50S ribosomal protein L4 rplD 0.0118
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0117
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0116
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0115
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
1852 Microtubule-associated protein 2 MAP2 0.0114
6014 Cytochrome P450 2A13 CYP2A13 0.0114
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0111
198 Sodium channel protein type 10 subunit alpha SCN10A 0.011
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.011
477 DNA topoisomerase 4 subunit A parC 0.0109
886 DNA topoisomerase 4 subunit A parC 0.0109
6226 DNA topoisomerase 4 subunit A parC 0.0109
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0109
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0109
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0109
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0109
122 P2Y purinoceptor 12 P2RY12 0.0108
404 DNA gyrase subunit A gyrA 0.0108
6224 DNA gyrase subunit A gyrA 0.0108
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0107
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0107
273 Apoptosis regulator Bcl-2 BCL2 0.0106
6020 Aldehyde oxidase AOX1 0.0106
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0105
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0105
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
117 Sterol O-acyltransferase 1 SOAT1 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0104
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0103
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0102
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0101
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.01
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.01
768 FK506-binding protein 1A FKBP1A 0.01
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0099
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0099
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0099
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0099
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0099
432 D(4) dopamine receptor DRD4 0.0098
594 Thyroxine-binding globulin SERPINA7 0.0098
6167 Organic solute transporter subunit beta OSTB 0.0098
6166 Organic solute transporter subunit alpha OSTA 0.0097
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0097
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0096
1192 Sulfotransferase 1A1 SULT1A1 0.0096
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
5923 Microtubule-associated protein tau MAPT 0.0096
5924 Microtubule-associated protein 4 MAP4 0.0096
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0095
5934 Cytochrome P450 26A1 CYP26A1 0.0094
716 5-hydroxytryptamine 7 receptor HTR7 0.0093
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0093
777 Tumor necrosis factor TNF 0.0092
758 Thyroid hormone receptor alpha THRA 0.009
427 Substance-P receptor TACR1 0.009
5787 Angiopoietin-1 receptor TEK 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0086
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0086
3947 Xanthine dehydrogenase/oxidase XDH 0.0086
239 Coagulation factor X F10 0.0084
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
208 DNA-directed RNA polymerase beta' chain rpoC 0.0081
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0081
6102 Arylamine N-acetyltransferase 2 NAT2 0.0081
346 Thyroid hormone receptor beta-1 THRB 0.008
3856 Fibroblast growth factor receptor 3 FGFR3 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
3939 Amine oxidase [flavin-containing] B MAOB 0.0079
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0078
1517 Beta-3 adrenergic receptor ADRB3 0.0078
436 5-hydroxytryptamine 2B receptor HTR2B 0.0077
511 5-hydroxytryptamine 1F receptor HTR1F 0.0077
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0077
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0076
1650 Heme carrier protein 1 SLC46A1 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
5300 Antigen peptide transporter 1 TAP1 0.0075
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
1656 CYP2B protein CYP2B 0.0073
474 Acetylcholinesterase ACHE 0.0073
24 Thymidylate synthase TMP1 0.0073
359 Thymidylate synthase TYMS 0.0073
2626 Thymidylate synthase thyA 0.0073
2729 Thymidylate synthase thyA 0.0073
5352 Thymidylate synthase THYA 0.0073
908 Glutathione S-transferase theta-1 GSTT1 0.0072
68 Cannabinoid receptor 1 CNR1 0.0071
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0071
365 Dihydrofolate reductase DHFR 0.0071
2381 Dihydrofolate reductase DFR1 0.0071
2833 Dihydrofolate reductase Not Available 0.0071
2931 Dihydrofolate reductase folA 0.0071
3544 Dihydrofolate reductase folA 0.0071
3682 Dihydrofolate reductase folA 0.0071
6642 Dihydrofolate reductase folA 0.0071
6756 Dihydrofolate reductase dfrA 0.0071
1757 Myeloperoxidase MPO 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
6500 Phospholipase A2 PLA2G1B 0.007
814 Ryanodine receptor 1 RYR1 0.007
1256 5-hydroxytryptamine 6 receptor HTR6 0.007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.007
1630 Integrin beta-2 ITGB2 0.0069
3809 Estrogen-related receptor gamma ESRRG 0.0069
1758 GTPase HRas HRAS 0.0068
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0068
976 Platelet glycoprotein IX GP9 0.0068
1050 Bile salt sulfotransferase SULT2A1 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0067
823 Fibroblast growth factor receptor 2 FGFR2 0.0067
1618 High affinity nerve growth factor receptor NTRK1 0.0067
705 Glutamate receptor 1 GRIA1 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0065
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0065
4122 Histone deacetylase 2 HDAC2 0.0064
319 Opioid receptor, sigma 1 OPRS1 0.0064
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
275 Arachidonate 5-lipoxygenase ALOX5 0.0063
4192 DNA topoisomerase 2-beta TOP2B 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
199 Monocarboxylate transporter 8 SLC16A2 0.0062
284 DNA-directed RNA polymerase beta chain rpoB 0.0061
5773 DNA-directed RNA polymerase beta chain rpoB 0.0061
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0061
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0061
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0061
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0061
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0061
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0061
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0061
1291 cAMP response element-binding protein CREB1 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.006
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
88 Retinoic acid receptor RXR-beta RXRB 0.0059
1483 Membrane copper amine oxidase AOC3 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
2300 Lysozyme E 0.0058
3633 Lysozyme R 0.0058
5597 Lysozyme 17 0.0058
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0058
1178 Adenosine A2a receptor ADORA2A 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
528 5-hydroxytryptamine 1E receptor HTR1E 0.0056
1196 Complement decay-accelerating factor CD55 0.0056
2449 Tubulin alpha-3 chain TUBA1A 0.0056
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0056
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
6044 Serum paraoxonase/lactonase 3 PON3 0.0056
4203 Histamine N-methyltransferase HNMT 0.0056
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0055
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0055
936 Ephrin type-A receptor 2 EPHA2 0.0055
3932 Glutathione S-transferase A2 GSTA2 0.0054
6824 Tyrosine-protein kinase Lyn LYN 0.0054
3086 Plasmepsin-2 Not Available 0.0053
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
2112 Toll-like receptor 9 TLR9 0.0053
3810 Catechol O-methyltransferase COMT 0.0052
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0052
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0052
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0052
163 D(1B) dopamine receptor DRD5 0.0052
572 Integrin alpha-L ITGAL 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
3917 Methylenetetrahydrofolate reductase MTHFR 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.005
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
1541 Metalloproteinase mmp20 0.0049
16 Adenosine A1 receptor ADORA1 0.0049
2808 Chloramphenicol acetyltransferase 3 cat3 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
162 Retinoic acid receptor gamma-1 RARG 0.0049
6174 50S ribosomal protein L32 rpmF 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
2216 Fibroblast growth factor receptor 4 FGFR4 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
293 Gamma-glutamyl hydrolase GGH 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0046
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0046
295 Carbonic anhydrase 1 CA1 0.0046
6043 Putative G-protein coupled receptor 44 GPR44 0.0046
6163 Copper-transporting ATPase 2 ATP7B 0.0045
6165 Copper-transporting ATPase 1 ATP7A 0.0045
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0045
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0045
3601 Dihydropteroate synthase 1 folP1 0.0045
3807 Dihydropteroate synthase 1 folP1 0.0045
3808 Dihydropteroate synthase 2 folP2 0.0045
2417 Chloramphenicol acetyltransferase cat 0.0045
3278 Chloramphenicol acetyltransferase cat 0.0045
54 Prothrombin F2 0.0045
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0045
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
2810 Dr hemagglutinin structural subunit draA 0.0044
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0044
1629 Transcription factor AP-1 JUN 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
856 Vitamin D3 receptor VDR 0.0043
891 Dihydropteroate synthase folP 0.0043
5359 Dihydropteroate synthase folP 0.0043
7175 Dihydropteroate synthase sulI 0.0043
4311 tRNA TRDMT1 0.0043
4325 tRNA trmD 0.0043
4328 tRNA trmD 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
558 Solute carrier family 12 member 1 SLC12A1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0041
780 Retinoic acid receptor RXR-gamma RXRG 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.004
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0039
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0039
489 Monocarboxylate transporter 2 SLC16A7 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
174 Sigma 1-type opioid receptor SIGMAR1 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
291 Nitric-oxide synthase, endothelial NOS3 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
183 Vascular endothelial growth factor A VEGFA 0.0038
1864 RET proto-oncogene RET 0.0038
6048 Troponin C, skeletal muscle TNNC2 0.0038
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0038
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0038
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
1063 Signal transducer and activator of transcription 5B STAT5B 0.0037
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
751 Potassium channel subfamily K member 6 KCNK6 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0037
4217 Telomerase reverse transcriptase TERT 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0036
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0036
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
921 Glutamate receptor 2 GRIA2 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
172 Potassium channel subfamily K member 1 KCNK1 0.0034
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0034
484 Tyrosine-protein kinase ABL2 ABL2 0.0034
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0033
5880 Thrombopoietin receptor MPL 0.0033
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0033
719 Retinoic acid receptor responder protein 1 RARRES1 0.0032
770 Retinoic acid-induced protein 3 GPRC5A 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
2021 Thrombomodulin THBD 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
153 Dopamine beta-hydroxylase DBH 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1648 Elastin ELN 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.003
702 UMP-CMP kinase CMPK1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2320 Thymidine kinase, cytosolic TK1 0.0029
6218 Pannexin-1 PANX1 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
569 Retinal dehydrogenase 2 ALDH1A2 0.0028
267 Plasminogen activator inhibitor 1 SERPINE1 0.0028
5818 Folate receptor alpha FOLR1 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
760 Fibroblast growth factor 1 FGF1 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
6432 Transporter snf 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0026
611 Retinal dehydrogenase 1 ALDH1A1 0.0026
4226 Uridine phosphorylase 2 UPP2 0.0026
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
49 Endothelin B receptor EDNRB 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
6221 Steroid hormone receptor ERR1 ESRRA 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
4225 Uridine phosphorylase 1 UPP1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
518 Peroxidase/catalase T katG 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0023
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0022
2515 Amidophosphoribosyltransferase purF 0.0022
3714 Amidophosphoribosyltransferase purF 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
1792 Tissue-type plasminogen activator PLAT 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0021
2981 Phospholipase A2, membrane associated PLA2G2A 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0021
5626 Nucleoside diphosphate kinase B NME2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
2391 Ferrochelatase hemH 0.0017
6502 Ferrochelatase DKFZp686P18130 0.0017
1591 Ferrochelatase, mitochondrial FECH 0.0017
3957 Adenosine deaminase ADA 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
5294 Nucleoside diphosphate kinase A NME1 0.0017
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0016
173 Toll-like receptor 7 TLR7 0.0016
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0016
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
6168 Solute carrier family 22 member 16 SLC22A16 0.0016
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1992 Vitamin D-binding protein GC 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
2207 Rhodopsin RHO 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
164 Histamine H4 receptor HRH4 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
517 Alcohol dehydrogenase 1C ADH1C 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
6859 Protein S100-A4 S100A4 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
1830 5'-nucleotidase NT5E 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
3221 Cytochrome c4 cc4 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
563 Thyroid peroxidase TPO 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
4920 Peroxidase/catalase katG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
6021 Adenosine kinase ADK 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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