Identification
Name Midodrine
Accession Number DB00211 (APRD01116)
Type small molecule
Description An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. [PubChem]
Structure
Categories (*)
Molecular Weight 254.2823
Groups approved
Monoisotopic Weight 254.126657074
Pharmacology
Indication For the treatment of symptomatic orthostatic hypotension (OH).
Mechanism of action Midodrine forms an active metabolite, desglymidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Desglymidodrine does not stimulate cardiac beta-adrenergic receptors.
Absorption Rapidly absorbed following oral administration. The absolute bioavailability of midodrine (measured as desglymidodrine) is 93% and is not affected by food.
Protein binding Not Available
Biotransformation Thorough metabolic studies have not been conducted, but it appears that deglycination of midodrine to desglymidodrine takes place in many tissues, and both compounds are metabolized in part by the liver.
Route of elimination Not Available
Toxicity Symptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown. The oral LD50 is approximately 30 to 50 mg/kg in rats, 675 mg/kg in mice, and 125 to 160 mg/kg in dogs. Desglymidodrine is dialyzable.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Betamethasone Increased arterial pressure
Cortisone acetate Increased arterial pressure
Dexamethasone Increased arterial pressure
Dobutamine Increased arterial pressure
Dopamine Increased arterial pressure
Ephedra Increased arterial pressure
Ephedrine Increased arterial pressure
Epinephrine Increased arterial pressure
Fenoterol Increased arterial pressure
Fludrocortisone Increased arterial pressure
Hydrocortisone Increased arterial pressure
Isocarboxazid Possible hypertensive crisis with this combination
Isoproterenol Increased arterial pressure
Mephentermine Increased arterial pressure
Metaraminol Increased arterial pressure
Methoxamine Increased arterial pressure
Methylprednisolone Increased arterial pressure
Norepinephrine Increased arterial pressure
Orciprenaline Increased arterial pressure
Paramethasone Increased arterial pressure
Phenelzine Possible hypertensive crisis with this combination
Phenylephrine Increased arterial pressure
Phenylpropanolamine Increased arterial pressure
Pirbuterol Increased arterial pressure
Prednisolone Increased arterial pressure
Prednisone Increased arterial pressure
Procaterol Increased arterial pressure
Pseudoephedrine Increased arterial pressure
Rasagiline Risk of hypertensive crisis.
Salbutamol Increased arterial pressure
Terbutaline Increased arterial pressure
Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the alpha1-agonist, Midodrine. Concomitant therapy should be avoided.
Triamcinolone Increased arterial pressure
Trimipramine Trimipramine may increase the vasopressor effect of the alpha1-agonist, Midodrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Food Interactions
  • Take without regard to meals.
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions agonist
References
  • Buckner SA, Milicic I, Daza AV, Meyer MD, Altenbach RJ, Williams M, Sullivan JP, Brioni JD: ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes. Eur J Pharmacol. 2002 Aug 2;449(1-2):159-65. - Pubmed
  • Taniguchi N, Hamada K, Ogasawara T, Ukai Y, Yoshikuni Y, Kimura K: NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs. Eur J Pharmacol. 1996 Dec 27;318(1):117-22. - Pubmed
  • Altenbach RJ, Khilevich A, Kolasa T, Rohde JJ, Bhatia PA, Patel MV, Searle XB, Yang F, Bunnelle WH, Tietje K, Bayburt EK, Carroll WA, Meyer MD, Henry R, Buckner SA, Kuk J, Daza AV, Milicic IV, Cain JC, Kang CH, Ireland LM, Carr TL, Miller TR, Hancock AA, Nakane M, Esbenshade TA, Brune ME, O'Neill AB, Gauvin DM, Katwala SP, Holladay MW, Brioni JD, Sullivan JP: Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonami de, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. - Pubmed
DTHybrid score 0.3959
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action yes
Actions agonist
References
  • Altenbach RJ, Khilevich A, Kolasa T, Rohde JJ, Bhatia PA, Patel MV, Searle XB, Yang F, Bunnelle WH, Tietje K, Bayburt EK, Carroll WA, Meyer MD, Henry R, Buckner SA, Kuk J, Daza AV, Milicic IV, Cain JC, Kang CH, Ireland LM, Carr TL, Miller TR, Hancock AA, Nakane M, Esbenshade TA, Brune ME, O'Neill AB, Gauvin DM, Katwala SP, Holladay MW, Brioni JD, Sullivan JP: Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonami de, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. - Pubmed
DTHybrid score 0.2785
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2935
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions Not Available
References
  • Tsuda M, Terada T, Irie M, Katsura T, Niida A, Tomita K, Fujii N, Inui K: Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. Epub 2006 Apr 5. - Pubmed
DTHybrid score 0.29
Id Partner name Gene Name Score
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1862
4512 Cytochrome P450 3A4 CYP3A4 0.1443
318 Alpha-2A adrenergic receptor ADRA2A 0.1298
789 Alpha-1D adrenergic receptor ADRA1D 0.1237
1588 Multidrug resistance protein 1 ABCB1 0.0948
244 Angiotensin-converting enzyme ACE 0.0944
831 D(2) dopamine receptor DRD2 0.0852
502 5-hydroxytryptamine 2A receptor HTR2A 0.0816
4200 Cytochrome P450 1A2 CYP1A2 0.0799
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0775
23 D(1A) dopamine receptor DRD1 0.076
6016 Cytochrome P450 2C19 CYP2C19 0.0724
4757 Cytochrome P450 2C9 CYP2C9 0.0687
492 Histamine H1 receptor HRH1 0.0647
320 5-hydroxytryptamine 1A receptor HTR1A 0.0547
629 Alpha-2B adrenergic receptor ADRA2B 0.0539
713 Sodium-dependent dopamine transporter SLC6A3 0.0537
118 Organic cation/carnitine transporter 2 SLC22A5 0.0527
766 Beta-2 adrenergic receptor ADRB2 0.0504
193 Beta-1 adrenergic receptor ADRB1 0.0488
4118 Cytochrome P450 3A5 CYP3A5 0.0463
633 Penicillin-binding proteins 1A/1B pbpA 0.0461
590 5-hydroxytryptamine 2C receptor HTR2C 0.0458
378 Alpha-2C adrenergic receptor ADRA2C 0.0454
824 Sodium-dependent serotonin transporter SLC6A4 0.0422
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0417
1729 Solute carrier family 22 member 6 SLC22A6 0.0393
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0391
4924 Cytochrome P450 2C8 CYP2C8 0.0385
587 Serum albumin ALB 0.0383
6030 Cytochrome P450 2B6 CYP2B6 0.038
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0367
432 D(4) dopamine receptor DRD4 0.0362
6013 Cytochrome P450 2E1 CYP2E1 0.0359
6107 Cytochrome P450 3A7 CYP3A7 0.0347
131 Synaptic vesicular amine transporter SLC18A2 0.0346
6145 Solute carrier family 22 member 1 SLC22A1 0.0327
638 D(3) dopamine receptor DRD3 0.031
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0307
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0305
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0297
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0284
725 5-hydroxytryptamine 1D receptor HTR1D 0.0251
163 D(1B) dopamine receptor DRD5 0.0238
6024 Cytochrome P450 1A1 CYP1A1 0.0236
1 Peptidoglycan synthetase ftsI ftsI 0.0235
4155 Peptidoglycan synthetase ftsI ftsI 0.0235
3941 Amine oxidase [flavin-containing] A MAOA 0.0227
3923 Cholinesterase BCHE 0.0226
1385 Angiotensin-converting enzyme 2 ACE2 0.0222
645 Penicillin-binding protein 1A mrcA 0.0221
5805 Penicillin-binding protein 1A ponA 0.0221
6185 Penicillin-binding protein 1A mrcA 0.0221
6799 Penicillin-binding protein 1A pbpA 0.0221
885 5-hydroxytryptamine 1B receptor HTR1B 0.0219
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0218
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0217
6142 Solute carrier family 22 member 8 SLC22A8 0.0215
1256 5-hydroxytryptamine 6 receptor HTR6 0.02
6144 Solute carrier family 22 member 2 SLC22A2 0.0185
716 5-hydroxytryptamine 7 receptor HTR7 0.0179
543 Penicillin-binding protein 1B mrcB 0.0174
6186 Penicillin-binding protein 1B ponB 0.0174
6822 Penicillin-binding protein 1b pbp1b 0.0174
6844 Penicillin-binding protein 1b pbp1b 0.0174
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0172
5718 Cytochrome P450 2A6 CYP2A6 0.0171
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0166
341 5-hydroxytryptamine 3 receptor HTR3A 0.0152
465 Calmodulin CALM1 0.0136
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0134
1636 Trace amine-associated receptor 1 TAAR1 0.0134
6147 Solute carrier family 22 member 3 SLC22A3 0.0131
436 5-hydroxytryptamine 2B receptor HTR2B 0.0131
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0125
20 Prostaglandin G/H synthase 1 PTGS1 0.0122
828 Phenylalanine-4-hydroxylase PAH 0.012
3109 Phenylalanine-4-hydroxylase phhA 0.012
1757 Myeloperoxidase MPO 0.0117
4604 Liver carboxylesterase 1 CES1 0.0115
528 5-hydroxytryptamine 1E receptor HTR1E 0.0115
847 Mu-type opioid receptor OPRM1 0.0113
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0113
6138 Multidrug resistance protein 3 ABCB4 0.0113
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0111
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
6067 Penicillin binding protein 2a mecA 0.0107
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
6106 Cytochrome P450 2C18 CYP2C18 0.0102
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0098
1517 Beta-3 adrenergic receptor ADRB3 0.0097
1024 Solute carrier family 22 member 11 SLC22A11 0.0096
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0095
3810 Catechol O-methyltransferase COMT 0.0095
467 Delta-type opioid receptor OPRD1 0.0092
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
833 Organic cation/carnitine transporter 1 SLC22A4 0.0091
6143 Solute carrier family 22 member 7 SLC22A7 0.0091
696 Kappa-type opioid receptor OPRK1 0.0089
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0088
474 Acetylcholinesterase ACHE 0.0084
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
3426 Glutamine synthetase glnA 0.0078
3987 Glutamine synthetase GLUL 0.0078
124 Histamine H2 receptor HRH2 0.0077
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0077
3917 Methylenetetrahydrofolate reductase MTHFR 0.0076
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0075
3939 Amine oxidase [flavin-containing] B MAOB 0.007
776 Bile salt export pump ABCB11 0.0069
862 Multidrug resistance-associated protein 1 ABCC1 0.0069
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0065
1898 Cytochrome P450 1B1 CYP1B1 0.0064
1656 CYP2B protein CYP2B 0.0063
738 Monocarboxylate transporter 1 SLC16A1 0.0062
707 72 kDa type IV collagenase MMP2 0.0059
6151 Monocarboxylate transporter 10 SLC16A10 0.0059
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0055
4252 Penicillin-binding protein 5 dacA 0.0054
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0053
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
5482 Sialidase-2 NEU2 0.0052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0052
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0051
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0049
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0049
65 Matrix metalloproteinase-9 Not Available 0.0048
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0048
332 Beta-lactamase blaZ 0.0047
2478 Beta-lactamase ampC 0.0047
2613 Beta-lactamase ampC 0.0047
2635 Beta-lactamase ampC 0.0047
2700 Beta-lactamase penP 0.0047
5445 Beta-lactamase blaB 0.0047
6019 Beta-lactamase SHV-7 0.0047
6701 Beta-lactamase cphA 0.0047
509 Thymidine kinase TK 0.0046
570 Thymidine kinase TK 0.0046
2559 Thymidine kinase TK 0.0046
3430 Thymidine kinase tdk 0.0046
3518 Thymidine kinase TK 0.0046
5301 Thymidine kinase tdk 0.0046
5771 Thymidine kinase ORF36 0.0046
7009 Thymidine kinase ORF36 0.0046
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0046
2112 Toll-like receptor 9 TLR9 0.0044
4120 NADPH--cytochrome P450 reductase POR 0.0044
3947 Xanthine dehydrogenase/oxidase XDH 0.0044
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0043
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0042
3760 Penicillin-binding protein 5 precursor dacA 0.0042
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0041
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.004
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.004
233 Potassium channel subfamily K member 2 KCNK2 0.004
338 DNA polymerase UL30 0.004
379 DNA polymerase UL54 0.004
697 DNA polymerase ORF28 0.004
2482 DNA polymerase 43 0.004
4104 DNA polymerase BALF5 0.004
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.004
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
867 Penicillin-binding protein 3 pbpC 0.0038
6119 Penicillin-binding protein 3 pbp3 0.0038
7154 Penicillin-binding protein 3 pbp3 0.0038
7157 Penicillin-binding protein 3 LMHCC_2184 0.0038
7162 Penicillin-binding protein 3 pbpB 0.0038
7172 Penicillin-binding protein 3 pbp3 0.0038
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0037
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0036
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0035
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0035
6859 Protein S100-A4 S100A4 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
380 Cytochrome P450 17A1 CYP17A1 0.0034
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0033
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
158 Sodium channel protein type 1 subunit alpha SCN1A 0.003
164 Histamine H4 receptor HRH4 0.003
6432 Transporter snf 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
3811 Cytochrome P450 19A1 CYP19A1 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0023
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0021
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
4203 Histamine N-methyltransferase HNMT 0.0019
183 Vascular endothelial growth factor A VEGFA 0.0019
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
146 Androgen receptor AR 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
1618 High affinity nerve growth factor receptor NTRK1 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
6148 Multidrug resistance-associated protein 7 ABCC10 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
777 Tumor necrosis factor TNF 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
4773 Deoxycytidine kinase DCK 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0006
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6141 Sodium/bile acid cotransporter SLC10A1 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
136 Estrogen receptor ESR1 0.0004
153 Dopamine beta-hydroxylase DBH 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002