DT-Web

DB01366 - Procaterol


Identification
Name Procaterol
Accession Number DB01366
Type small molecule
Description A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 290.3575
Groups approved
Monoisotopic Weight 290.16304258
Pharmacology
Indication For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Mechanism of action Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Absorption Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of procaterol.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of procaterol.
Atenolol Antagonism
Bisoprolol Antagonism
Carvedilol Antagonism
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of procaterol.
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of procaterol.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of procaterol.
Esmolol Antagonism
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of procaterol.
Isocarboxazid Increased arterial pressure
Labetalol Antagonism
Linezolid Possible increase of arterial pressure
Methyldopa Increased arterial pressure
Metoprolol Antagonism
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of procaterol.
Nadolol Antagonism
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of procaterol.
Phenelzine Increased arterial pressure
Pindolol Antagonism
Propranolol Antagonism
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure
Timolol Antagonism
Food Interactions Not Available

Targets


Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions agonist
References
  • Kobayashi M, Kishimoto N, Ohnishi H, Tada S, Ueda N, Kamei T, Fujita J, Taguchi H: [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers] Nihon Kokyuki Gakkai Zasshi. 2002 Aug;40(8):637-43. - Pubmed
  • Yamasaki Y, Kishimoto N, Ohnishi H, Fujita J, Kobayashi M, Kamei T, Tada S, Ueda N: [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance] Nihon Kokyuki Gakkai Zasshi. 2004 Mar;42(3):239-46. - Pubmed
  • Noguchi K, Ojiri Y, Chibana T, Moromizato H, Sakanashi M: Cardiac effects of beta-2 adrenoceptor stimulation with intracoronary procaterol in the absence and presence of regional myocardial ischemia in dogs. J Pharmacol Exp Ther. 1991 Nov;259(2):732-7. - Pubmed
  • Aizawa H, Inoue H, Ikeda T, Hirose T, Ito Y: Effects of procaterol, a beta-2-adrenoceptor stimulant, on neuroeffector transmission in human bronchial tissue. Respiration. 1991;58(3-4):163-6. - Pubmed
  • Brodde OE, Daul A, Michel-Reher M, Boomsma F, Man in 't Veld AJ, Schlieper P, Michel MC: Agonist-induced desensitization of beta-adrenoceptor function in humans. Subtype-selective reduction in beta 1- or beta 2-adrenoceptor-mediated physiological effects by xamoterol or procaterol. Circulation. 1990 Mar;81(3):914-21. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4603

Predictions


Id Partner name Gene Name Score
193 Beta-1 adrenergic receptor ADRB1 0.2195
1517 Beta-3 adrenergic receptor ADRB3 0.0648
4119 Cytochrome P450 2D6 CYP2D6 0.0544
556 Alpha-1A adrenergic receptor ADRA1A 0.0293
3923 Cholinesterase BCHE 0.028
320 5-hydroxytryptamine 1A receptor HTR1A 0.0245
1588 Multidrug resistance protein 1 ABCB1 0.0209
4512 Cytochrome P450 3A4 CYP3A4 0.0204
2300 Lysozyme E 0.0191
3633 Lysozyme R 0.0191
5597 Lysozyme 17 0.0191
318 Alpha-2A adrenergic receptor ADRA2A 0.0186
6144 Solute carrier family 22 member 2 SLC22A2 0.0169
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.016
6016 Cytochrome P450 2C19 CYP2C19 0.0147
885 5-hydroxytryptamine 1B receptor HTR1B 0.0137
4200 Cytochrome P450 1A2 CYP1A2 0.0125
629 Alpha-2B adrenergic receptor ADRA2B 0.0113
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0109
3810 Catechol O-methyltransferase COMT 0.0101
632 Alpha-1B adrenergic receptor ADRA1B 0.01
6145 Solute carrier family 22 member 1 SLC22A1 0.01
378 Alpha-2C adrenergic receptor ADRA2C 0.0096
5718 Cytochrome P450 2A6 CYP2A6 0.0094
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0089
4757 Cytochrome P450 2C9 CYP2C9 0.0088
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0086
6024 Cytochrome P450 1A1 CYP1A1 0.0081
1820 Beta-nerve growth factor NGF 0.0081
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0074
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0074
828 Phenylalanine-4-hydroxylase PAH 0.0071
3109 Phenylalanine-4-hydroxylase phhA 0.0071
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0063
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.006
789 Alpha-1D adrenergic receptor ADRA1D 0.0057
824 Sodium-dependent serotonin transporter SLC6A4 0.0057
777 Tumor necrosis factor TNF 0.0054
6107 Cytochrome P450 3A7 CYP3A7 0.0051
713 Sodium-dependent dopamine transporter SLC6A3 0.0051
3941 Amine oxidase [flavin-containing] A MAOA 0.0051
6147 Solute carrier family 22 member 3 SLC22A3 0.005
4118 Cytochrome P450 3A5 CYP3A5 0.0049
1176 Mitogen-activated protein kinase 1 MAPK1 0.004
118 Organic cation/carnitine transporter 2 SLC22A5 0.0038
4924 Cytochrome P450 2C8 CYP2C8 0.0036
1374 Natriuretic peptides B NPPB 0.0029
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0029
1827 Gap junction alpha-1 protein GJA1 0.0029
1908 Vascular cell adhesion protein 1 VCAM1 0.0029
131 Synaptic vesicular amine transporter SLC18A2 0.0028
465 Calmodulin CALM1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0022
3939 Amine oxidase [flavin-containing] B MAOB 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0019
1360 Sphingomyelin phosphodiesterase SMPD1 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
502 5-hydroxytryptamine 2A receptor HTR2A 0.0017
492 Histamine H1 receptor HRH1 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0015
1256 5-hydroxytryptamine 6 receptor HTR6 0.0015
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0014
124 Histamine H2 receptor HRH2 0.0013
716 5-hydroxytryptamine 7 receptor HTR7 0.0013
6432 Transporter snf 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0012
432 D(4) dopamine receptor DRD4 0.0012
638 D(3) dopamine receptor DRD3 0.0012
20 Prostaglandin G/H synthase 1 PTGS1 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
23 D(1A) dopamine receptor DRD1 0.001
831 D(2) dopamine receptor DRD2 0.001
6106 Cytochrome P450 2C18 CYP2C18 0.0009
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0009
833 Organic cation/carnitine transporter 1 SLC22A4 0.0009
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0009
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0008
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0008
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0007
6030 Cytochrome P450 2B6 CYP2B6 0.0007
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