DT-Web

DB01367 - Rasagiline


Identification
Name Rasagiline
Accession Number DB01367 (EXPT02758)
Type small molecule
Description Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 171.2383
Groups approved
Monoisotopic Weight 171.104799421
Pharmacology
Indication For the treatment of the signs and symptoms of idiopathic Parkinsons disease as initial monotherapy and as adjunct therapy to levodopa.
Mechanism of action The precise mechanisms of action of rasagiline is unknown. One mechanism is believed to be related to its MAO-B inhibitory activity, which causes an increase in extracellular levels of dopamine in the striatum. The elevated dopamine level and subsequent increased dopaminergic activity are likely to mediate rasagiline's beneficial effects seen in models of dopaminergic motor dysfunction.
Absorption Rasagiline is rapidly absorbed following oral administration. The absolute bioavailability of rasagiline is about 36%.
Protein binding Plasma protein binding ranges from 88-94% with mean extent of binding of 61-63% to human albumin over the concentration range of 1-100 ng/ml.
Biotransformation Rasagiline undergoes almost complete biotransformation in the liver prior to excretion. In vitro experiments indicate that both routes of rasagiline metabolism are dependent on the cytochrome P450 (CYP) system, with CYP 1A2 being the major isoenzyme involved in rasagiline metabolism.
Route of elimination Rasagiline undergoes almost complete biotransformation in the liver prior to excretion. Glucuronide conjugation of rasagiline and its metabolites, with subsequent urinary excretion, is the major elimination pathway. After oral administration of 14C-labeled rasagiline, elimination occurred primarily via urine and secondarily via feces (62% of total dose in urine and 7% of total dose in feces over 7 days), with a total calculated recovery of 84% of the dose over a period of 38 days. Less than 1% of rasagiline was excreted as unchanged drug in urine.
Toxicity Signs and symptoms of overdosage may include, alone or in combination, any of the following: drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonos, convulsions, and coma; rapid and irregular pulse, hypertension, hypotension and vascular collapse; precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Altretamine Risk of severe hypotension
Amitriptyline Possibility of severe adverse effects
Amoxapine Possibility of severe adverse effects
Amphetamine Possible hypertensive crisis
Atomoxetine Possible severe adverse reaction with this combination
Benzphetamine MAO Inhibitors may enhance the hypertensive effect of Amphetamines. Concomitant use of amphetamines and monoamine oxidase inhibitors (MAOI) should be avoided. If used concomitantly, careful monitoring of blood pressure must occur. It may take up to 2 weeks after the discontinuation of an MAOI for the effects to dissipate enough to afford safety to the administration of interacting agents.
Bezafibrate MAO Inhibitors may enhance the adverse/toxic effect of Bezafibrate. Avoid concomitant use of bezafibrate with monoamine oxidase inhibitors (MAOIs) rasagiline.
Brimonidine MAO Inhibitors like rasagiline may enhance the hypertensive effect of Alpha2-Agonists (Ophthalmic). The concomitant use of monoamine oxidase inhibitors and ophthalmic alpha2 agonists is contraindicated.
Buprenorphine Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like rasagiline. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Bupropion Possible severe adverse reaction with this combination
Buspirone Possible blood pressure elevation
Ciprofloxacin Ciprofloxacin, a strong CYP1A2 inhibitor, may decrease the metabolism of rasagiline. Monitor for changes in the therapeutic and adverse effects of rasagiline if ciprofloxacin is initiated or discontinued.
Citalopram Possible severe adverse reaction with this combination
Clomipramine Possibility of severe adverse effects
Cyclobenzaprine Increased risk of toxicity with this association
Desipramine Possibility of severe adverse effects
Desvenlafaxine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Dexfenfluramine Possible hypertensive crisis
Dextroamphetamine Possible hypertensive crisis
Dextromethorphan Possible severe adverse reaction
Diethylpropion Possible hypertensive crisis
Dobutamine Increased arterial pressure
Dopamine Increased arterial pressure
Doxepin Possibility of severe adverse effects
Duloxetine Possible severe adverse reaction with this combination
Ephedra Increased arterial pressure
Ephedrine Increased arterial pressure
Epinephrine Increased arterial pressure
Escitalopram Possible severe adverse reaction with this combination
Fenfluramine Possible hypertensive crisis
Fenoterol Increased arterial pressure
Fluoxetine Possible severe adverse reaction with this combination
Fluvoxamine Possible severe adverse reaction with this combination
Imipramine Possibility of severe adverse effects
Isoproterenol Increased arterial pressure
Mazindol Possible hypertensive crisis
Meperidine Increased risk of serotonin syndrome. Concomitant use should be avoided.
Mephentermine Increased arterial pressure
Metaraminol Increased arterial pressure
Methamphetamine Possible hypertensive crisis
Methoxamine Increased arterial pressure
Methylphenidate Possible hypertensive crisis with this combination.
Midodrine Risk of hypertensive crisis.
Milnacipran Increase serotonin levels. Combination therapy is contraindicated.
Mirtazapine Possible severe adverse reaction with this combination
Nefazodone Possible severe adverse reaction with this combination
Norepinephrine Increased arterial pressure
Nortriptyline Possibility of severe adverse effects
Orciprenaline Increased arterial pressure
Paroxetine Possible severe adverse reaction with this combination
Phendimetrazine Possible hypertensive crisis
Phenmetrazine Possible hypertensive crisis
Phentermine Possible hypertensive crisis
Phenylephrine Increased arterial pressure
Phenylpropanolamine Increased arterial pressure
Pirbuterol Increased arterial pressure
Procaterol Increased arterial pressure
Protriptyline Possibility of severe adverse effects
Pseudoephedrine Increased arterial pressure
Salbutamol Increased arterial pressure
Sertraline Possible severe adverse reaction with this combination
Sibutramine Possible serotoninergic syndrome with this combination
St. John's Wort Increased risk of toxicity with this association
Tapentadol Increases the toxicity of tapentadol by unknown mechanism. Discontinue rasagiline at least 14 days prior to tapentadol administration.
Terbutaline Increased arterial pressure
Tetrabenazine Tetrabenazine may increase the adverse/toxic effects of Rasagiline. Concomitant therapy is contraindicated.
Tolcapone Tolcapone and Rasagiline decrease the metabolism of endogenous catecholamines. Concomitant therapy may result in increased catecholamine effects. Consider alternate therapy or use cautiously and monitor for increased catecholamine effects.
Tramadol Tramadol may increase the risk of serotonin syndrome and seizure induction by the MAO inhibitor, rasagiline.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Avoid combination or monitor for symptoms of serotonin syndrome and/or hypertensive crisis.
Venlafaxine Increased risk of serotonin syndrome. Ensure adequate washout period between therapies to avoid toxicity. Concurrent therapy should be avoided.
Zolmitriptan The MAO inhibitor, rasagiline, may increase the serum concentration of zolmitriptan by decreasing its metabolism. Concomitant therapy and use of zolmitriptan within two weeks of discontinuing rasagiline are contraindicated.
Food Interactions
  • Avoid alcohol and caffeine.

Targets


Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Pharmacological action yes
Actions inhibitor
References
  • Naoi M, Maruyama W: Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease. Expert Rev Neurother. 2009 Aug;9(8):1233-50. - Pubmed
  • Uzun M, Alp R, Uzlu E, Alp S, Citil M, Topcu B, Erdogan HM: Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):95-8. - Pubmed
  • Youdim MB, Weinstock M: Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol. 2001 Dec;21(6):555-73. - Pubmed
  • Chau KY, Cooper JM, Schapira AH: Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells. Neurochem Int. 2010 Jul 17. - Pubmed
  • Weinreb O, Amit T, Bar-Am O, Youdim MB: RASAGILINE; A NOVEL ANTI-PARKINSONIAN MONOAMINE OXIDASE-B INHIBITOR WITH NEUROPROTECTIVE ACTIVITY. Prog Neurobiol. 2010 Jun 19. - Pubmed
  • Youdim MB, Bar Am O, Yogev-Falach M, Weinreb O, Maruyama W, Naoi M, Amit T: Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition. J Neurosci Res. 2005 Jan 1-15;79(1-2):172-9. - Pubmed
  • Leegwater-Kim J, Bortan E: The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging. 2010 May 25;5:149-56. - Pubmed
  • Chen JJ, Swope DM, Dashtipour K: Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther. 2007 Sep;29(9):1825-49. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8464
Apoptosis regulator Bcl-2
Name Apoptosis regulator Bcl-2
Gene Name BCL2
Pharmacological action yes
Actions activator
References
  • Youdim MB, Weinstock M: Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol. 2001 Dec;21(6):555-73. - Pubmed
  • Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MB, Naoi M: An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells. Neurosci Lett. 2002 Jun 28;326(2):105-8. - Pubmed
  • Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, Naoi M: Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):675-82. - Pubmed
  • Youdim MB, Amit T, Falach-Yogev M, Am OB, Maruyama W, Naoi M: The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline. Biochem Pharmacol. 2003 Oct 15;66(8):1635-41. - Pubmed
  • Bar-Am O, Weinreb O, Amit T, Youdim MB: Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. FASEB J. 2005 Nov;19(13):1899-901. Epub 2005 Sep 7. - Pubmed
DTHybrid score 0.2129

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Lecht S, Haroutiunian S, Hoffman A, Lazarovici P: Rasagiline - a novel MAO B inhibitor in Parkinson's disease therapy. Ther Clin Risk Manag. 2007 Jun;3(3):467-74. - Pubmed
  • Leegwater-Kim J, Bortan E: The role of rasagiline in the treatment of Parkinson's disease. Clin Interv Aging. 2010 May 25;5:149-56. - Pubmed
  • Chen JJ, Swope DM, Dashtipour K: Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease. Clin Ther. 2007 Sep;29(9):1825-49. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2655

Predictions


Id Partner name Gene Name Score
3941 Amine oxidase [flavin-containing] A MAOA 0.1691
4512 Cytochrome P450 3A4 CYP3A4 0.0827
4757 Cytochrome P450 2C9 CYP2C9 0.07
4119 Cytochrome P450 2D6 CYP2D6 0.0656
6016 Cytochrome P450 2C19 CYP2C19 0.0607
1588 Multidrug resistance protein 1 ABCB1 0.0583
5923 Microtubule-associated protein tau MAPT 0.0433
5924 Microtubule-associated protein 4 MAP4 0.0432
4924 Cytochrome P450 2C8 CYP2C8 0.0418
4118 Cytochrome P450 3A5 CYP3A5 0.0405
6024 Cytochrome P450 1A1 CYP1A1 0.0388
1852 Microtubule-associated protein 2 MAP2 0.0377
6013 Cytochrome P450 2E1 CYP2E1 0.0368
6107 Cytochrome P450 3A7 CYP3A7 0.0349
824 Sodium-dependent serotonin transporter SLC6A4 0.034
6030 Cytochrome P450 2B6 CYP2B6 0.0316
713 Sodium-dependent dopamine transporter SLC6A3 0.0314
862 Multidrug resistance-associated protein 1 ABCC1 0.0302
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0301
29 Tubulin beta-1 chain TUBB1 0.0296
1898 Cytochrome P450 1B1 CYP1B1 0.0295
6148 Multidrug resistance-associated protein 7 ABCC10 0.026
36 Insulin receptor INSR 0.0258
3811 Cytochrome P450 19A1 CYP19A1 0.0245
540 Sodium-dependent noradrenaline transporter SLC6A2 0.024
2864 Penton protein PIII 0.0236
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0236
5718 Cytochrome P450 2A6 CYP2A6 0.0234
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0228
5841 Insulin-like growth factor IB IGF1 0.0206
318 Alpha-2A adrenergic receptor ADRA2A 0.0193
20 Prostaglandin G/H synthase 1 PTGS1 0.0189
587 Serum albumin ALB 0.0182
2021 Thrombomodulin THBD 0.0171
131 Synaptic vesicular amine transporter SLC18A2 0.0169
290 Prostaglandin G/H synthase 2 PTGS2 0.0153
3810 Catechol O-methyltransferase COMT 0.0149
6143 Solute carrier family 22 member 7 SLC22A7 0.0149
831 D(2) dopamine receptor DRD2 0.0146
502 5-hydroxytryptamine 2A receptor HTR2A 0.0144
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0138
6145 Solute carrier family 22 member 1 SLC22A1 0.0137
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0134
1729 Solute carrier family 22 member 6 SLC22A6 0.0134
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
556 Alpha-1A adrenergic receptor ADRA1A 0.0121
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.012
6144 Solute carrier family 22 member 2 SLC22A2 0.0119
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0117
776 Bile salt export pump ABCB11 0.0116
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0116
118 Organic cation/carnitine transporter 2 SLC22A5 0.0114
1792 Tissue-type plasminogen activator PLAT 0.0111
629 Alpha-2B adrenergic receptor ADRA2B 0.0111
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0109
492 Histamine H1 receptor HRH1 0.0108
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0106
6085 Fatty acid-binding protein, intestinal FABP2 0.0104
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0104
23 D(1A) dopamine receptor DRD1 0.0103
2164 Multidrug resistance-associated protein 4 ABCC4 0.01
378 Alpha-2C adrenergic receptor ADRA2C 0.01
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
817 DNA topoisomerase 2-alpha TOP2A 0.0096
6142 Solute carrier family 22 member 8 SLC22A8 0.0092
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.009
220 Sodium channel protein type 5 subunit alpha SCN5A 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
1757 Myeloperoxidase MPO 0.0089
193 Beta-1 adrenergic receptor ADRB1 0.0088
146 Androgen receptor AR 0.0086
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
1024 Solute carrier family 22 member 11 SLC22A11 0.0082
6147 Solute carrier family 22 member 3 SLC22A3 0.0081
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
6106 Cytochrome P450 2C18 CYP2C18 0.0076
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0076
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0075
766 Beta-2 adrenergic receptor ADRB2 0.007
638 D(3) dopamine receptor DRD3 0.0069
16 Adenosine A1 receptor ADORA1 0.0066
320 5-hydroxytryptamine 1A receptor HTR1A 0.0063
632 Alpha-1B adrenergic receptor ADRA1B 0.0062
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
1517 Beta-3 adrenergic receptor ADRB3 0.0059
694 Matrix protein 2 M 0.0059
432 D(4) dopamine receptor DRD4 0.0057
1178 Adenosine A2a receptor ADORA2A 0.0053
1656 CYP2B protein CYP2B 0.0053
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
789 Alpha-1D adrenergic receptor ADRA1D 0.0051
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0051
6014 Cytochrome P450 2A13 CYP2A13 0.005
3876 Aromatic-L-amino-acid decarboxylase DDC 0.005
833 Organic cation/carnitine transporter 1 SLC22A4 0.005
136 Estrogen receptor ESR1 0.0049
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0049
714 Glutathione reductase, mitochondrial GSR 0.0047
163 D(1B) dopamine receptor DRD5 0.0046
465 Calmodulin CALM1 0.0045
6220 Aryl hydrocarbon receptor AHR 0.0045
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0044
3923 Cholinesterase BCHE 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
777 Tumor necrosis factor TNF 0.0044
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0041
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.004
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
6031 Cytochrome P450 3A43 CYP3A43 0.004
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
1636 Trace amine-associated receptor 1 TAAR1 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
3913 Glutamic acid decarboxylase GAD65 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
3947 Xanthine dehydrogenase/oxidase XDH 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
1483 Membrane copper amine oxidase AOC3 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0035
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
818 50S ribosomal protein L10 rplJ 0.003
6020 Aldehyde oxidase AOX1 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
153 Dopamine beta-hydroxylase DBH 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0025
6070 Nischarin NISCH 0.0024
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
3957 Adenosine deaminase ADA 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0022
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0022
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0022
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
731 HIV-1 protease HIV-1 protease 0.0021
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
869 Estrogen receptor beta ESR2 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.002
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.002
1820 Beta-nerve growth factor NGF 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
124 Histamine H2 receptor HRH2 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
6133 Sodium channel subunit beta-2 SCN2B 0.0018
6134 Sodium channel subunit beta-3 SCN3B 0.0018
6132 Sodium channel subunit beta-1 SCN1B 0.0018
6135 Sodium channel subunit beta-4 SCN4B 0.0018
6127 Carbonic anhydrase-related protein CA8 0.0018
6129 Carbonic anhydrase-related protein 11 CA11 0.0018
6128 Carbonic anhydrase-related protein 10 CA10 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0018
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1243 Cathepsin D CTSD 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
373 Transthyretin TTR 0.0016
474 Acetylcholinesterase ACHE 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
6131 Carbonic anhydrase 14 CA14 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
6122 Carbonic anhydrase 3 CA3 0.0015
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0015
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0015
6689 TraN protein traN 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
6688 TraF protein traF 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
6687 TraO protein traO 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
6679 Colicin-Ia cia 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
115 Penicillin-binding protein 2 mrdA 0.0015
6069 Penicillin-binding protein 2 mrdA 0.0015
6118 Penicillin-binding protein 2 penA 0.0015
6187 Penicillin-binding protein 2 pbpA 0.0015
6686 Penicillin-binding protein 2 pbp2 0.0015
6939 Penicillin-binding protein 2 mrdA 0.0015
7163 Penicillin-binding protein 2 pbpA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6432 Transporter snf 0.0015
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
4205 Carbonic anhydrase 9 CA9 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
295 Carbonic anhydrase 1 CA1 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0013
4760 Mll3241 protein mll3241 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
380 Cytochrome P450 17A1 CYP17A1 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
6126 Carbonic anhydrase 7 CA7 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
518 Peroxidase/catalase T katG 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
6677 Myelin P2 protein PMP2 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
563 Thyroid peroxidase TPO 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.001
4237 50S ribosomal protein L22 rplV 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
4604 Liver carboxylesterase 1 CES1 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
592 Carbonic anhydrase 4 CA4 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
4120 NADPH--cytochrome P450 reductase POR 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
2828 Squalene--hopene cyclase shc 0.0009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5095 Putidaredoxin reductase camA 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5081 L-aspartate oxidase nadB 0.0009
1410 Oxidoreductase HSD17B6 0.0009
4725 Oxidoreductase Not Available 0.0009
5124 Oxidoreductase Not Available 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
2207 Rhodopsin RHO 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
4439 Ferredoxin reductase bphA4 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
357 Carbonic anhydrase 2 CA2 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0008
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0008
3594 Deoxyribodipyrimidine photo-lyase phr 0.0008
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0008
5080 Deoxyribodipyrimidine photo-lyase phr 0.0008
5072 N,N-dimethylglycine oxidase dmg 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
2470 Pyruvate oxidase pox5 0.0008
5073 Ferredoxin--NADP reductase petH 0.0008
5076 Ferredoxin--NADP reductase fpr 0.0008
5119 Ferredoxin--NADP reductase petH 0.0008
5121 Ferredoxin--NADP reductase fpr 0.0008
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
2268 Cholesterol oxidase choB 0.0008
2822 Cholesterol oxidase choA 0.0008
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0008
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0008
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0008
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0008
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0008
2526 NADPH-ferredoxin reductase fprA fprA 0.0008
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
4440 NADH peroxidase npr 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
822 Aldose reductase AKR1B1 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
2893 Glycine oxidase thiO 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
2567 Thymidylate synthase thyX thyX 0.0007
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
2823 Trypanothione reductase TPR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
2769 P-hydroxybenzoate hydroxylase pobA 0.0007
2809 P-hydroxybenzoate hydroxylase pobA 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
6141 Sodium/bile acid cotransporter SLC10A1 0.0007
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
6645 D-amino-acid oxidase DAO 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
183 Vascular endothelial growth factor A VEGFA 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0004
614 Progesterone receptor PGR 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
7 Nitric oxide synthase, inducible NOS2 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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