DT-Web: DB00454

Identification

Name

Meperidine

Accession Number

DB00454 (APRD00074)

Type

small molecule

Description

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

247.3327

Groups

approved

Monoisotopic Weight

247.157228921

Pharmacology

Indication

Used to control moderate to severe pain.

Mechanism of action

Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Absorption

The oral bioavailability of meperidine in patients with normal hepatic function is 50-60% due to extensive first-pass metabolism. Bioavailability increases to 80-90% in patients with hepatic impairment (e.g. liver cirrhosis). Meperidine is less than half as effective when administered orally compared to parenteral administration. One study reported that 80-85% of the drug administered intramuscularly was absorbed within 6 hours of intragluteal injection in health adults; however, inter-individual variation and patient-specific variable appear to cause considerable variations in absorption upon IM injection.

Protein binding

60-80% bound to plasma proteins, primarily albumin and α₁-acid glycoprotein. The presence of cirrhosis or active viral hepatitis does not appear to affect the extent of protein binding.

Biotransformation

Meperidine is metabolized in the liver by hydrolysis to meperidinic acid followed by partial conjugation with glucuronic acid. Meperidine also undergoes N-demethylation to normeperidine, which then undergoes hydrolysis and partial conjugation. Normeperidine is about half as potent as meperidine, but it has twice the CNS stimulation effects.

Route of elimination

Excreted in the urine. The proportion of drug that is excreted unchanged or as metabolites is dependent on pH. When urine pH is uncontrolled, 5-30% of the meperidine dose is excreted as normeperidine and approximately 5% is excreted unchanged. Meperidine and normeperidine are found in acidic urine, while the free and conjugated forms of meperidinic and normperidinic acids are found in alkaline urine.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alvimopan	Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Chlorpromazine	Increased sedation and hypotension
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Donepezil	Possible antagonism of action
Eltrombopag	Increases levels of Meperidine via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Galantamine	Possible antagonism of action
Isocarboxazid	Potentially fatal adverse effects
Isoniazid	Possible episodes of hypotension
Moclobemide	Increased CNS toxicity (can cause death)
Phenelzine	Potentially fatal adverse effects
Rasagiline	Increased risk of serotonin syndrome. Concomitant use should be avoided.
Ritonavir	Ritonavir increases the levels of analgesic
Rivastigmine	Possible antagonism of action
Selegiline	Potentially fatal adverse effects
Sibutramine	Possible serotoninergic syndrome
Tipranavir	Tipranavir may increase the adverse/toxic effects of Meperidine. Consider alternate therapy or monitor for Meperidine toxicity during concomitant use.
Tramadol	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant use should be avoided.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine	The CNS depressants, Triprolidine and Meperidine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and meperidine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Take without regard to meals. Avoid alcohol.

Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	yes
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.4127
Glutamate [NMDA] receptor subunit zeta-1
Name	Glutamate [NMDA] receptor subunit zeta-1
Gene Name	GRIN1
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg. 2000 Apr;90(4):928-32. - Pubmed
DTHybrid score	0.7149
Glutamate [NMDA] receptor subunit epsilon-2
Name	Glutamate [NMDA] receptor subunit epsilon-2
Gene Name	GRIN2B
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg. 2000 Apr;90(4):928-32. - Pubmed
DTHybrid score	0.4044
Glutamate [NMDA] receptor subunit epsilon-1
Name	Glutamate [NMDA] receptor subunit epsilon-1
Gene Name	GRIN2A
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg. 2000 Apr;90(4):928-32. - Pubmed
DTHybrid score	0.3895
Glutamate [NMDA] receptor subunit epsilon-3
Name	Glutamate [NMDA] receptor subunit epsilon-3
Gene Name	GRIN2C
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg. 2000 Apr;90(4):928-32. - Pubmed
DTHybrid score	0.3093
Glutamate [NMDA] receptor subunit epsilon-4
Name	Glutamate [NMDA] receptor subunit epsilon-4
Gene Name	GRIN2D
Pharmacological action	unknown
Actions	antagonist
References	Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg. 2000 Apr;90(4):928-32. - Pubmed
DTHybrid score	0.3501

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ramirez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ: CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6. - Pubmed
DTHybrid score	0.659
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ramirez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ: CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6. - Pubmed
DTHybrid score	0.4361
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ramirez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ: CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6. - Pubmed
DTHybrid score	0.3744
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	- Ramirez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ: CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6. - Pubmed
DTHybrid score	0.5083

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2981
847	Mu-type opioid receptor	OPRM1	0.2787
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.2521
1588	Multidrug resistance protein 1	ABCB1	0.2365
467	Delta-type opioid receptor	OPRD1	0.2362
4200	Cytochrome P450 1A2	CYP1A2	0.2197
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.2113
4924	Cytochrome P450 2C8	CYP2C8	0.1999
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.1897
4118	Cytochrome P450 3A5	CYP3A5	0.1848
6013	Cytochrome P450 2E1	CYP2E1	0.1746
6107	Cytochrome P450 3A7	CYP3A7	0.1395
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1322
824	Sodium-dependent serotonin transporter	SLC6A4	0.1083
5718	Cytochrome P450 2A6	CYP2A6	0.1075
492	Histamine H1 receptor	HRH1	0.097
6024	Cytochrome P450 1A1	CYP1A1	0.087
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0737
6144	Solute carrier family 22 member 2	SLC22A2	0.0717
20	Prostaglandin G/H synthase 1	PTGS1	0.0696
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0651
556	Alpha-1A adrenergic receptor	ADRA1A	0.0611
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0609
6145	Solute carrier family 22 member 1	SLC22A1	0.0591
482	Glycine receptor subunit alpha-1	GLRA1	0.0569
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0567
5469	Head decoration protein	shp	0.0562
6106	Cytochrome P450 2C18	CYP2C18	0.0532
831	D(2) dopamine receptor	DRD2	0.0521
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0513
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0491
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0472
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0468
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0466
1729	Solute carrier family 22 member 6	SLC22A6	0.0466
862	Multidrug resistance-associated protein 1	ABCC1	0.044
6151	Monocarboxylate transporter 10	SLC16A10	0.044
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0437
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0429
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0405
1716	Tripartite motif-containing protein 13	TRIM13	0.0402
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0399
713	Sodium-dependent dopamine transporter	SLC6A3	0.0392
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0388
766	Beta-2 adrenergic receptor	ADRB2	0.0385
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.038
23	D(1A) dopamine receptor	DRD1	0.0378
318	Alpha-2A adrenergic receptor	ADRA2A	0.0367
290	Prostaglandin G/H synthase 2	PTGS2	0.0366
632	Alpha-1B adrenergic receptor	ADRA1B	0.0362
193	Beta-1 adrenergic receptor	ADRB1	0.0344
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0343
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.034
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0331
3811	Cytochrome P450 19A1	CYP19A1	0.0327
1262	Corticotropin-lipotropin	POMC	0.0321
6147	Solute carrier family 22 member 3	SLC22A3	0.0317
789	Alpha-1D adrenergic receptor	ADRA1D	0.0307
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0301
465	Calmodulin	CALM1	0.03
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0293
6142	Solute carrier family 22 member 8	SLC22A8	0.0288
731	HIV-1 protease	HIV-1 protease	0.0286
891	Dihydropteroate synthase	folP	0.0286
5359	Dihydropteroate synthase	folP	0.0286
7175	Dihydropteroate synthase	sulI	0.0286
174	Sigma 1-type opioid receptor	SIGMAR1	0.0285
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0276
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0273
705	Glutamate receptor 1	GRIA1	0.0271
378	Alpha-2C adrenergic receptor	ADRA2C	0.0271
118	Organic cation/carnitine transporter 2	SLC22A5	0.0261
6070	Nischarin	NISCH	0.0261
1898	Cytochrome P450 1B1	CYP1B1	0.0252
638	D(3) dopamine receptor	DRD3	0.0249
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0243
136	Estrogen receptor	ESR1	0.024
2164	Multidrug resistance-associated protein 4	ABCC4	0.024
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0234
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0228
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0228
3941	Amine oxidase [flavin-containing] A	MAOA	0.0226
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0223
844	Epidermal growth factor receptor	EGFR	0.0222
922	Glutamate receptor 4	GRIA4	0.0216
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0216
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0216
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0216
4018	Glutamate receptor delta-2 subunit	GRID2	0.0216
4027	Glutamate receptor delta-1 subunit	GRID1	0.0216
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0216
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0216
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0216
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0216
4026	Aspartyl aminopeptidase	DNPEP	0.0216
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0216
4016	Excitatory amino acid transporter 5	SLC1A7	0.0216
1912	Excitatory amino acid transporter 1	SLC1A3	0.0216
4019	Excitatory amino acid transporter 4	SLC1A6	0.0216
1047	Excitatory amino acid transporter 2	SLC1A2	0.0216
664	Glutamate decarboxylase 2	GAD2	0.0216
3890	Glutamate decarboxylase 2	GAD2	0.0216
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0216
4020	Glutamyl aminopeptidase	ENPEP	0.0216
927	Metabotropic glutamate receptor 8	GRM8	0.0216
925	Metabotropic glutamate receptor 4	GRM4	0.0216
926	Metabotropic glutamate receptor 7	GRM7	0.0216
4017	5-oxoprolinase	OPLAH	0.0216
260	Cytochrome P450 51	ERG11	0.0215
761	Cytochrome P450 51	ERG11	0.0215
3163	Cytochrome P450 51	cyp51	0.0215
871	Glucocorticoid receptor	NR3C1	0.0213
3923	Cholinesterase	BCHE	0.0207
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0201
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0201
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.02
738	Monocarboxylate transporter 1	SLC16A1	0.02
776	Bile salt export pump	ABCB11	0.0197
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0191
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.019
537	ATP synthase delta chain, mitochondrial	ATP5D	0.019
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0187
6143	Solute carrier family 22 member 7	SLC22A7	0.0187
4057	Glycine N-acyltransferase	GLYAT	0.0184
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0184
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0184
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0184
4056	N-arachidonyl glycine receptor	GPR18	0.0184
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0184
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0184
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0184
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0184
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0184
1466	Glycyl-tRNA synthetase	GARS	0.0184
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0184
3939	Amine oxidase [flavin-containing] B	MAOB	0.0184
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0183
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0183
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0183
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0183
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0183
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0183
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0183
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0183
625	Glutamate carboxypeptidase 2	FOLH1	0.0181
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0181
665	Phosphoserine aminotransferase	PSAT1	0.0178
4652	Phosphoserine aminotransferase	serC	0.0178
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0178
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0178
420	Glutamate decarboxylase 1	GAD1	0.0178
3900	Glutamate decarboxylase 1	GAD1	0.0178
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0176
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0175
1024	Solute carrier family 22 member 11	SLC22A11	0.0175
3426	Glutamine synthetase	glnA	0.0174
3987	Glutamine synthetase	GLUL	0.0174
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0173
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0173
1389	Transforming growth factor beta-1	TGFB1	0.0169
468	Cytochrome P450 4A11	CYP4A11	0.0169
916	Metabotropic glutamate receptor 1	GRM1	0.0168
3904	Alanine aminotransferase 2	GPT2	0.0168
735	Alanine aminotransferase 1	GPT	0.0168
833	Organic cation/carnitine transporter 1	SLC22A4	0.0168
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0168
122	P2Y purinoceptor 12	P2RY12	0.0167
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0166
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0165
1671	Excitatory amino acid transporter 3	SLC1A1	0.0164
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0164
3877	Growth-inhibiting protein 18	GIG18	0.0163
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0162
923	Glutamate receptor 3	GRIA3	0.0162
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0162
763	Tyrosine aminotransferase	TAT	0.0159
5493	Tyrosine aminotransferase	Not Available	0.0159
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0157
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0157
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0157
33	Cystine/glutamate transporter	SLC7A11	0.0156
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0155
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0155
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0155
146	Androgen receptor	AR	0.0155
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0155
319	Opioid receptor, sigma 1	OPRS1	0.0153
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0153
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0153
921	Glutamate receptor 2	GRIA2	0.0152
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0151
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0151
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0151
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0151
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.015
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.015
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.015
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0148
62	Glycine receptor subunit beta	GLRB	0.0147
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0147
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0147
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0146
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0146
820	Glycine receptor subunit alpha-2	GLRA2	0.0145
629	Alpha-2B adrenergic receptor	ADRA2B	0.0145
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0145
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0141
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0141
1656	CYP2B protein	CYP2B	0.0141
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0139
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0139
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0139
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0139
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0138
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0138
380	Cytochrome P450 17A1	CYP17A1	0.0138
3884	SHMT2 protein	SHMT2	0.0137
3901	SHMT2 protein	SHMT2	0.0137
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0137
3879	Serine hydroxymethyltransferase 2	Not Available	0.0137
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0137
4137	Nociceptin receptor	OPRL1	0.0136
183	Vascular endothelial growth factor A	VEGFA	0.0132
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0131
6031	Cytochrome P450 3A43	CYP3A43	0.0131
461	Glycine receptor subunit alpha-3	GLRA3	0.0131
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.013
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.013
207	Glutathione synthetase	GSS	0.013
5269	Glutathione synthetase	gshB	0.013
756	Sex hormone-binding globulin	SHBG	0.013
411	Glycine N-methyltransferase	GNMT	0.0129
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0128
383	Glycine amidinotransferase, mitochondrial	GATM	0.0126
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0125
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0125
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0124
1517	Beta-3 adrenergic receptor	ADRB3	0.0123
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0123
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0122
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0122
1268	Neuropeptide S receptor	NPSR1	0.0122
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0122
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0121
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.012
432	D(4) dopamine receptor	DRD4	0.012
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0119
4604	Liver carboxylesterase 1	CES1	0.0119
349	Serine--pyruvate aminotransferase	AGXT	0.0118
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0118
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0118
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0114
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0114
124	Histamine H2 receptor	HRH2	0.0114
6182	Cytochrome P450 2J2	CYP2J2	0.0113
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0113
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0112
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0112
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0112
504	Mast/stem cell growth factor receptor	KIT	0.0108
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0108
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0106
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0106
6073	Potassium channel subfamily K member 9	KCNK9	0.0106
6072	Potassium channel subfamily K member 3	KCNK3	0.0106
6141	Sodium/bile acid cotransporter	SLC10A1	0.0105
1618	High affinity nerve growth factor receptor	NTRK1	0.0104
1050	Bile salt sulfotransferase	SULT2A1	0.0104
818	50S ribosomal protein L10	rplJ	0.0104
373	Transthyretin	TTR	0.0102
817	DNA topoisomerase 2-alpha	TOP2A	0.0102
614	Progesterone receptor	PGR	0.0102
4120	NADPH--cytochrome P450 reductase	POR	0.0101
716	5-hydroxytryptamine 7 receptor	HTR7	0.0101
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.01
1757	Myeloperoxidase	MPO	0.0099
2211	Fatty acid-binding protein, heart	FABP3	0.0098
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0097
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0096
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0096
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0095
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0095
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0095
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0095
566	Serotransferrin	TF	0.0094
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0094
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0094
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0094
5787	Angiopoietin-1 receptor	TEK	0.0094
161	Tubulin beta chain	TUBB	0.0093
312	Tubulin beta chain	TUB2	0.0093
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
6432	Transporter	snf	0.0091
6220	Aryl hydrocarbon receptor	AHR	0.0091
163	D(1B) dopamine receptor	DRD5	0.0091
811	Translocator protein	TSPO	0.009
70	Type-1 angiotensin II receptor	AGTR1	0.0088
768	FK506-binding protein 1A	FKBP1A	0.0088
6136	Multidrug resistance-associated protein 5	ABCC5	0.0087
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0087
474	Acetylcholinesterase	ACHE	0.0086
2207	Rhodopsin	RHO	0.0086
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0084
6137	Multidrug resistance-associated protein 6	ABCC6	0.0083
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0082
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0082
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0081
1291	cAMP response element-binding protein	CREB1	0.0081
131	Synaptic vesicular amine transporter	SLC18A2	0.008
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
4210	Toll-like receptor 4	TLR4	0.0079
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0078
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
6085	Fatty acid-binding protein, intestinal	FABP2	0.0077
3932	Glutathione S-transferase A2	GSTA2	0.0076
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0074
869	Estrogen receptor beta	ESR2	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0071
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
6014	Cytochrome P450 2A13	CYP2A13	0.007
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.007
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.007
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.007
1010	Cytochrome P450 51A1	CYP51A1	0.007
6102	Arylamine N-acetyltransferase 2	NAT2	0.0069
6148	Multidrug resistance-associated protein 7	ABCC10	0.0069
952	Dipeptidyl peptidase 4	DPP4	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0068
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0068
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0067
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0067
36	Insulin receptor	INSR	0.0066
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0065
26	Vascular endothelial growth factor receptor 3	FLT4	0.0065
407	Vascular endothelial growth factor receptor 2	KDR	0.0064
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0062
32	Vascular endothelial growth factor receptor 1	FLT1	0.0062
592	Carbonic anhydrase 4	CA4	0.0062
94	5-hydroxytryptamine 4 receptor	HTR4	0.0062
6020	Aldehyde oxidase	AOX1	0.006
6043	Putative G-protein coupled receptor 44	GPR44	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0059
777	Tumor necrosis factor	TNF	0.0059
558	Solute carrier family 12 member 1	SLC12A1	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
856	Vitamin D3 receptor	VDR	0.0058
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0056
357	Carbonic anhydrase 2	CA2	0.0056
6506	Stathmin-4	STMN4	0.0055
29	Tubulin beta-1 chain	TUBB1	0.0055
427	Substance-P receptor	TACR1	0.0054
1992	Vitamin D-binding protein	GC	0.0054
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
295	Carbonic anhydrase 1	CA1	0.0052
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0052
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0052
49	Endothelin B receptor	EDNRB	0.0052
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0052
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
3947	Xanthine dehydrogenase/oxidase	XDH	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
173	Toll-like receptor 7	TLR7	0.0049
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
68	Cannabinoid receptor 1	CNR1	0.0048
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
581	Cytochrome P450 2R1	CYP2R1	0.0046
563	Thyroid peroxidase	TPO	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
1864	RET proto-oncogene	RET	0.0046
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0046
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0046
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0045
365	Dihydrofolate reductase	DHFR	0.0045
2381	Dihydrofolate reductase	DFR1	0.0045
2833	Dihydrofolate reductase	Not Available	0.0045
2931	Dihydrofolate reductase	folA	0.0045
3544	Dihydrofolate reductase	folA	0.0045
3682	Dihydrofolate reductase	folA	0.0045
6642	Dihydrofolate reductase	folA	0.0045
6756	Dihydrofolate reductase	dfrA	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0042
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0042
65	Matrix metalloproteinase-9	Not Available	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.004
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.004
284	DNA-directed RNA polymerase beta chain	rpoB	0.004
5773	DNA-directed RNA polymerase beta chain	rpoB	0.004
5934	Cytochrome P450 26A1	CYP26A1	0.0039
459	Retinoic acid receptor RXR-alpha	RXRA	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
904	Glutathione S-transferase P	GSTP1	0.0038
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0038
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0038
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0038
85	Growth hormone receptor	GHR	0.0038
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0037
780	Retinoic acid receptor RXR-gamma	RXRG	0.0037
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0037
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0037
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0036
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
751	Potassium channel subfamily K member 6	KCNK6	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0035
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
6138	Multidrug resistance protein 3	ABCB4	0.0034
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0034
88	Retinoic acid receptor RXR-beta	RXRB	0.0034
6126	Carbonic anhydrase 7	CA7	0.0034
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0034
518	Peroxidase/catalase T	katG	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0033
737	Mineralocorticoid receptor	NR3C2	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
7	Nitric oxide synthase, inducible	NOS2	0.0033
172	Potassium channel subfamily K member 1	KCNK1	0.0033
1353	DNA topoisomerase 1	TOP1	0.0032
3552	DNA topoisomerase 1	topA	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
823	Fibroblast growth factor receptor 2	FGFR2	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0032
1630	Integrin beta-2	ITGB2	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
3937	Fatty-acid amide hydrolase	FAAH	0.0031
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0031
84	Nuclear receptor 0B1	NR0B1	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1629	Transcription factor AP-1	JUN	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
275	Arachidonate 5-lipoxygenase	ALOX5	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
4311	tRNA	TRDMT1	0.003
4325	tRNA	trmD	0.003
4328	tRNA	trmD	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
165	FL cytokine receptor	FLT3	0.003
6149	Solute carrier family 22 member 10	SLC22A10	0.003
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
1178	Adenosine A2a receptor	ADORA2A	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0029
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0029
244	Angiotensin-converting enzyme	ACE	0.0029
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0028
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0028
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0028
4122	Histone deacetylase 2	HDAC2	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0026
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0026
634	Squalene monooxygenase	SQLE	0.0026
7196	Squalene monooxygenase	ERG1	0.0026
1192	Sulfotransferase 1A1	SULT1A1	0.0026
4252	Penicillin-binding protein 5	dacA	0.0025
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0025
162	Retinoic acid receptor gamma-1	RARG	0.0025
6146	High affinity copper uptake protein 1	SLC31A1	0.0025
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0025
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0024
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4217	Telomerase reverse transcriptase	TERT	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
251	Alcohol dehydrogenase 1A	ADH1A	0.0023
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0023
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0023
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
469	Annexin A1	ANXA1	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
16	Adenosine A1 receptor	ADORA1	0.0021
291	Nitric-oxide synthase, endothelial	NOS3	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0021
164	Histamine H4 receptor	HRH4	0.0021
444	Alcohol dehydrogenase 1B	ADH1B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
106	Cannabinoid receptor 2	CNR2	0.002
5798	Mitogen-activated protein kinase 11	MAPK11	0.0019
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
6174	50S ribosomal protein L32	rpmF	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0019
239	Coagulation factor X	F10	0.0019
153	Dopamine beta-hydroxylase	DBH	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
976	Platelet glycoprotein IX	GP9	0.0019
267	Plasminogen activator inhibitor 1	SERPINE1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
2320	Thymidine kinase, cytosolic	TK1	0.0019
4103	Proteasome subunit beta type 2	PSMB2	0.0019
4102	Proteasome subunit beta type 5	PSMB5	0.0019
4101	Proteasome subunit beta type 1	PSMB1	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
936	Ephrin type-A receptor 2	EPHA2	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
517	Alcohol dehydrogenase 1C	ADH1C	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
3809	Estrogen-related receptor gamma	ESRRG	0.0018
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
273	Apoptosis regulator Bcl-2	BCL2	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
6221	Steroid hormone receptor ERR1	ESRRA	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
2021	Thrombomodulin	THBD	0.0017
1039	Histone deacetylase 9	HDAC9	0.0017
6218	Pannexin-1	PANX1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
4773	Deoxycytidine kinase	DCK	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6044	Serum paraoxonase/lactonase 3	PON3	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0015
3601	Dihydropteroate synthase 1	folP1	0.0015
3807	Dihydropteroate synthase 1	folP1	0.0015
3808	Dihydropteroate synthase 2	folP2	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0014
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0014
1541	Metalloproteinase	mmp20	0.0014
572	Integrin alpha-L	ITGAL	0.0014
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0014
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
896	Glutathione S-transferase Mu 1	GSTM1	0.0014
283	SEC14-like protein 2	SEC14L2	0.0013
3810	Catechol O-methyltransferase	COMT	0.0013
605	Fumarate reductase flavoprotein subunit	frdA	0.0013
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0013
3673	Fumarate reductase flavoprotein subunit	fccA	0.0013
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0013
6549	Fumarate reductase flavoprotein subunit	frdA	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
6459	Glycodelin	PAEP	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
569	Retinal dehydrogenase 2	ALDH1A2	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0012
822	Aldose reductase	AKR1B1	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0012
6042	Prostaglandin reductase 2	PTGR2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0011
76	Nitric-oxide synthase, brain	NOS1	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
489	Monocarboxylate transporter 2	SLC16A7	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
2298	Cytochrome P450-cam	camC	0.0009
3830	Calreticulin	CALR	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
2132	Protein S100-B	S100B	0.0009
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
6163	Copper-transporting ATPase 2	ATP7B	0.0008
6165	Copper-transporting ATPase 1	ATP7A	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
1275	Estrogen sulfotransferase	SULT1E1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0007
4954	Soluble cytochrome b558	Not Available	0.0007
4943	Cytochrome c6	petJ	0.0007
4916	Cyanoglobin	glbN	0.0007
4925	Cytochrome c-type protein SHP	shp	0.0007
4994	Hemoglobin-like protein HbO	glbO	0.0007
4984	Neuroglobin	NGB	0.0007
4947	Bacterial hemoglobin	vhb	0.0007
4915	Cytochrome c-550	psbV	0.0007
4959	Cytochrome c-550	psbV	0.0007
5216	Cytochrome c-550	psbV	0.0007
4975	Cytochrome c-556	RPA3973	0.0007
4981	Iron-starvation protein PigA	pigA	0.0007
5000	HemO	hemO	0.0007
4942	Diheme cytochrome c napB	napB	0.0007
3116	Bacterioferritin	bfr	0.0007
4906	Bacterioferritin	bfr	0.0007
4965	Bacterioferritin	bfr	0.0007
4934	Cytochrome c-551	nirM	0.0007
5218	Cytochrome c-551	nirM	0.0007
4905	Cytochrome c2	Not Available	0.0007
4939	Cytochrome c2	cycA	0.0007
4964	Cytochrome c2	cycA	0.0007
4979	Cytochrome c2	cycA	0.0007
6673	Cytochrome c2	cycA	0.0007
4910	Cytoglobin	CYGB	0.0007
4936	Cytochrome c2 iso-2	Not Available	0.0007
4935	Cytochrome c-554	cycA1	0.0007
4909	CooA protein	cooA	0.0007
4998	Hemoglobin-like protein yjbI	yjbI	0.0007
4961	Hemophore HasA	hasA	0.0007
4907	Cytochrome c-L	moxG	0.0007
6865	Cytochrome c-L	moxG	0.0007
644	Heme oxygenase 2	HMOX2	0.0007
4982	Heme oxygenase 2	pbsA2	0.0007
4971	Nonaheme cytochrome c	hmcA	0.0007
4931	Cytochrome P450 167A1	CYP167A1	0.0007
4904	Cytochrome c family protein	GSU1996	0.0007
4976	Apocytochrome f	petA	0.0007
6407	Apocytochrome f	petA	0.0007
4972	P450cin	cinA	0.0007
4903	Methyl-accepting chemotaxis protein	Tar4	0.0007
4937	Cytochrome oxidase subunit II	rcoxA	0.0007
4960	Putative cytochrome P450-family protein	SCO7417	0.0007
4764	Cytochrome P450 165C4	CYP165C4	0.0007
4989	Cytochrome c551 peroxidase	ccp	0.0007
5222	Cytochrome c551 peroxidase	ccpA	0.0007
4999	Cytochrome P450 165B3	CYP165B3	0.0007
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0007
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0007
4993	Hydroxylamine oxidoreductase	hao1	0.0007
4922	Cytochrome c, putative	SO_4144	0.0007
4952	Catalase/peroxidase	katA	0.0007
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0007
3093	Catalase HPII	katE	0.0007
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
293	Gamma-glutamyl hydrolase	GGH	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3957	Adenosine deaminase	ADA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1650	Heme carrier protein 1	SLC46A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
4920	Peroxidase/catalase	katG	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
4948	Cytochrome c-553	Not Available	0.0005
6753	Apolipoprotein M	APOM	0.0005
4923	Cytochrome c3	DvMF_2499	0.0005
4945	Cytochrome c3	Not Available	0.0005
4949	Cytochrome c3	DVU_3171	0.0005
4968	Cytochrome c3	cytc3	0.0005
4997	Cytochrome c3	SO_2727	0.0005
5219	Cytochrome c3	cyd	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
2119	Cytochrome b5	CYB5A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
4902	Nine-heme cytochrome c	Ddes_2038	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
3189	High-molecular-weight cytochrome c	hmcA	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
4990	PpcA	ppcA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
4037	Hypothetical protein	GPX1	0.0005
4297	Hypothetical protein	SP_1951	0.0005
4521	Hypothetical protein	BC_2969	0.0005
4540	Hypothetical protein	TM_1070	0.0005
4555	Hypothetical protein	MT1739	0.0005
4569	Hypothetical protein	mshD	0.0005
4578	Hypothetical protein	PA3270	0.0005
4747	Hypothetical protein	PA3967	0.0005
5177	Hypothetical protein	TM_0096	0.0005
5194	Hypothetical protein	PA1204	0.0005
5240	Hypothetical protein	Rv2991	0.0005
5370	Hypothetical protein	TM_1158	0.0005
5710	Hypothetical protein	Tb927.5.1360	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
2230	Catalase	CAT	0.0005
3249	Catalase	katA	0.0005
3625	Catalase	katA	0.0005
4539	Catalase	katA	0.0005
4941	Catalase	katB	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
6755	Poliovirus receptor	PVR	0.0005
4386	Hemoglobin-like protein HbN	glbN	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
3221	Cytochrome c4	cc4	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
1507	Cytochrome c	CYCS	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00454 - Meperidine

Targets

Enzymes

Carriers

Predictions